дееееееееееееф деф дф а деееееееф дееееф дф де

1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
α1
α2
iiiiiiiiiiiiii
iiiiiiiiiiiiiiiiii
iiiiii
X
X
X
X
X
X
X
cc
DEEEEEEEEEEEEF
M
D T I A cccc
ARALTc
V M R A C DEF
A T L Q E A DF
c
RIVA
L E A N DEEEEEEEF
VMEILGc
I A I N DEEEEF
c
RYc
NGLc
T L R G DF
c
V T M DEF
cc
RPTc
SA
L A DF
Qc
RND
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V M R A C KdG
A T L Q E A KG
c
RIVB
L E A N KdddddddG
VMEILGc
I A I N KddddG
c
RYc
NGLc
T L R G KG
c
V T M KdG
cc
RPTc
SB
L A KG
Qc
RNK
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V M R A C KdG
A T L Q E A KG
ccRR II VV BBLL EE AP NN KdddddddG
VMEILGc
I A I N KddddG
ccRR YY ccNN GG LL ccTT LL RR GG KG
cKG
V T M KdG
cc
RPTc
SB
L A KG
Qc
RNK
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V M R V C KdG
A T L Q E A KG
KdddddddG
VMEILGc
I A I N KddddG
c
V T M KdG
cc
RPTc
SB
L A KG
Qc
RNK
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V M R A C KdG
A T L Q E A KG
c
RIVB
L E A N KdddddddG
VMEILGc
I A I N KddddG
c
RYc
NGLc
T L R G KG
c
V T M KdG
cc
RPTc
SB
L A KG
Qc
RNK
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V M R A C KdG
A T L Q E A KG
c
RIVB
L E A N KdddddddG
VMEILGc
I A I N KddddG
c
RYc
NGLc
T L R G KG
c
V T M KdG
cc
RPTc
SB
L A KG
Qc
RNK
E
cc
KddddddddddddG
M
D T I A cccc
ARALTc
V I K A C KdG
N T L K E V KG
ccRR IV VS BBVL ED SP NG KdddddddG
VLEILGc
I A V N KddddG
ccRR YY ccNN GG LL ccTT LN RH SS KG
cKG
V T M KdG
cc
RPTc
SB
Q E KG
Qc
RNK
E
cc
KddddddddddddG
M
D A I A cccc
ARALSc
V V R A C KdG
V T V T D A KG
KdddddddG
VMETLGc
I A I N KddddG
c
V S M KdG
cc
RPQc
TB
Q A KG
Ec
RNK
E
cc
JIIIIIIIIIIIIH
M
D A Y T cccc
ARALSc
V L E G L JIH
A I S G D P JH
c
RSHC
R D P T JIIIIIIIH
TEATMSc
I F A M JIIIIH
c
RFc
NSTc
T S R P JH
c
V M G JIH
cc
RPQ.C
R G JH
Kc
RGJ
V
cc
LMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
c
cccc cc cc cc cc cc ccc ccc cccccccc
cccc
1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
α3
α4
α5
iiiiiiiiiiiii
iiiii
iiiiiiiiiiiiii
TT
X
X
X
X
X
X
EEEF
M
FFMc
CA
L D M M DF
LSAA
A G I N DF
VGc
P DEF
ISc
PDA
c
YTA
c
Q H M DEEEEEEF
Ac
T I G V cc
L A T P DEEEF
ccc
E I P F T T DF
EAAA
N E DEF
IAc
R V DEEF
TGETSA
TWG
dddG
M
FFMc
CB
L D M M KG
LSAB
A G I N KG
VGc
P KdG
ISc
PDB
ccYY TT BcBcQQ HH MM KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P F T T KG
EAAB
N E KdG
IAc
R V KddG
TGETSB
TWG
dddG
M
FFMc
CB
L D M M KG
LSAB
T G I N KG
VGc
P KdG
ISc
PDB
KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P F T T KG
EAAB
N E KdG
IAc
R V KddG
TGETSB
TWG
dddG
M
FFMc
CB
L D M M KG
VSAB
A G I N KG
VGc
P KdG
ISc
PDB
ccYY TT BcBcQQ HH MM KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P F T T KG
EAAB
N E KdG
IAc
R V KddG
TGETSB
TWG
dddG
M
FFMc
CB
L D M M KG
LSAB
A G I N KG
VGc
P KdG
ISc
PDB
KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P F T T KG
EAAB
N E KdG
IAc
R V KddG
TGETSB
TWG
dddG
M
FFMc
CB
L D M M KG
LSAB
A G I N KG
VGc
P KdG
ISc
PDB
c
YTB
c
Q H M KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P F T T KG
EAAB
N E KdG
IAc
R V KddG
TGETSB
TWG
dddG
M
FYMc
CB
L D M I KG
LAAB
A N L N KG
VGc
N KdG
ISc
PDB
c
YIB
c
Q N L KddddddG
Ac
T I G V cc
L A T P KdddG
ccc
E I P Y T M KG
ESAB
N E KdG
IAc
R M KddG
SGETGB
TWG
dddG
M
FFMc
CB
T D M V KG
LAAB
L N V Q KG
IGc
N KdG
ISc
PDB
ccYY DI BcCcQQ AN LP KddddddG
Ac
T V G A cc
L A T T KdddG
ccc
E I P Y N V KG
QAMB
N D KdG
IVc
R I KddG
TGQMQB
TFG
IIIH
I
TSTc
PC
Q R C G JH
IRDC
L E H H JH
VAc
F JIH
VMc
PGC
JIIIIIIH
Qc
T L A I cc
L A R D JIIIH
ccc
E I P Y T P JH
STFC
R R JIH
VQc
R Y JIIH
VSARMC
IIQ
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
c cc c ccc cc ccccc cc c cc
c
c
c cc
c
1
10
20
70
30
80
40
90
50
100
60
110
120
βB
βC
βD
βE
η1
jk
jjk
jjjjjjk
TT
TT
T T jjjjjk T T jjk lll
X
X
X
X
X
P A DF
R Q P Y G F F L E T E DF
ETFA
Q P DF
ccGG RR WW FF .. ABMM RR DF
AAQAVTAVA
V C G P D DEEF
MIQVSA
L N A G DEF
A R G D DF
VQQA
IFA
Q.GA
R
P A KG
R Q P Y G F F L E T E KG
ETFB
Q P KG
KG
AAQAATAVB
V C G P D KddG
MIQVSB
L N A G KdG
A R G D KG
VQQB
IFB
Q.GB
R
P A KG
R Q P Y G F F L E T E KG
ETFB
Q P KG
c
GRWF.B
M R KG
AAQAVTAVB
V C G P D KddG
MIQVSB
L N A G KdG
A R G D KG
VQQB
IFB
Q.GB
R
P A KG
R Q P Y G F F L E T E KG
EVYB
Q P KG
c
GRWF.B
M R KG
AAQVVTPVB
V C G P N KddG
MVQVSB
L N A G KdG
A I G D KG
VQQB
IFB
Q.GB
R
P A KG
R Q P Y G F F L E T E KG
ETFB
Q P KG
ccGG RR WW FF .. BBMM RR KG
AAQAVAAVB
V C G P D KddG
MIQVSB
L N A G KdG
A R G D KG
VQQB
IFB
Q.GB
R
P A KG
R Q P Y G F F L E T E KG
ETYB
Q P KG
KG
AAQAVTAVB
V C G P D KddG
MIQVSB
L N A G KdG
A R G D KG
VQQB
IFB
Q.GB
R
P D KG
R Q P F G Y F L A A P KG
EVTB
Q H KG
c
GRFR.B
Q R KG
VGQNVTTSB
I V S S T KddG
LAQVSB
M N A G KdG
A R G D KG
IQAB
LFB
Q.NB
Q
P S KG
K V Q T G P Y A G A V KG
EVQB
Q S KG
c
GRYY.B
V P KG
QGRTRGGYB
I N . S N KddG
IAEVCB
M D A G KdG
A A G Q KG
VNAB
LLB
APRB
R
M C JH
E R N D M L T P H Y E JH
AVTC
S P JH
cG V V c-c
LPC
A P JH
AGGGPRCYC
A I S A T JIIH
TLQIHC
I D P M JIH
Q N E V JH
LTPC
LIC
FPDC
Q
MMMMMMMMMMMMMMMMMMMMMM-MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM-MM
ccccc
c cc
c
- ccccc
B c c cc cc
ccccccc ccc c-c
c
-B
T
SSS
S
βF
βG
βH
βI
βJ
βK
jjjjjjjjjjjjk
jjk
jjk
jjjk
TT
T T jjjkT T jjk T T
X
X
X
X
X
X
NA
c
D P DEF
Mc
M I Y DEEF
LVc
WRRA
IEA
N F A M A DEEEF
Q G N S Q Q . . . T Q A DF
GVTA
VSA
V G DEF
Gc
VDMRA
A G R DEF
IIAWDGA
QAAA
LHA
VHN
NB
ccDD PP KdG
Mc
M I Y KddG
LVc
WRRB
IEB
N F A M A KdddG
Q G N S Q Q . . . T Q A KG
GVTB
VSB
V G KdG
Gc
VDMRB
A G R KdG
IIAWDGB
QAAB
LHB
VRN
NB
KdG
Mc
M I Y KddG
LVc
WRRB
IEB
N F A M A KdddG
Q G N S Q Q . . . T Q A KG
GVTB
VSB
V G KdG
Gc
VDMRB
A G R KdG
IIAWDGB
QAAB
LHB
VHN
NB
c
D P KdG
Mc
M I Y KddG
LVc
WRRB
IEB
N F S M P KdddG
Q G N S Q R . . . T L A KG
GVTB
VSB
V G KdG
Gc
VDMRB
A G R KdG
IIAWDGB
QAVB
LQB
IHN
NB
c
D P KdG
Mc
M I Y KddG
LVc
WRRB
IEB
N F A M A KdddG
Q G N S Q Q . . . T Q A KG
GVTB
VSB
V G KdG
Gc
VDMRB
A G R KdG
IIAWDGB
QAAB
LHB
VHN
NB
ccDD PP KdG
Mc
M I Y KddG
LVc
WRRB
IEB
N F A M A KdddG
Q G N S Q Q . . . T L A KG
GVTB
VSB
V G KdG
Gc
VDMRB
A G R KdG
IIAWDGB
QAAB
LQB
IHN
NB
KdG
Vc
M I Y KddG
FVc
WRRB
IGB
T F S N A KdddG
A G N A Q D . . . T P Q KG
GVTB
LNB
V G KdG
Gc
VNMRB
A G V KdG
IIAYDGB
QAPB
VNB
VNN
GB
c
D A KdG
Vc
M I Y KddG
FVc
WRPB
LRB
I F C D P KdddG
Q G A S L E S A P G A P KG
GTFB
VTB
V D KdG
Gc
VNVAB
A G D KdG
VVAWNTB
IAPB
VNB
VGN
EC
c
D V JIH
Ic
M A E JIIH
FIc
WQRC
LAC
N G I D N JIIIH
N A V M N M G . . T N V JH
ELLC
RDC
N A JIH
Ac
VEGGC
T P F JIH
MATPRGC
IHVC
VLC
ASY
ccc c
MMMMMMMMMMMMMMMMMMMMMMMMM---MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
c c
ccc cccc----- ccc c ccccccc cc c c c
cc c c
---
SS
βL
α6
α7
jjjjjjjjjjjk
iiiiiiiii
iiiiiiiiiii
TT
X
X
X
X
X
X
Pc
TA
QQA
NAMA
V Q DF
IQVA
VFA
c
Y I DF
SMDKTA
LNA
Q Y P DEF
ALTAEA
IFA
N V DEEEF
c
YSFRDc
HTA
c
W H G DEF
cc
L R T A DEEF
ILNRTTA
LPNML
Pc
TB
QQB
NAMB
V Q KG
IQVB
VFB
c
Y I KG
SMDKTB
LNB
Q Y P KdG
ALTAEB
IFB
N V KdddG
c
YSFRDc
HTB
c
W H G KdG
cc
L R T A KddG
IRNRTTB
LPNML
Pc
TB
QQB
NAMB
V Q KG
IQVB
VFB
ccYY IV KG
SMDKTB
LNB
Q Y P KdG
ALTAEB
IFB
N V KdddG
ccYY SS FF RR DD ccHH TT BcBcWW HH GG KdG
cc
L R T A KddG
ILNRTTB
LPNML
Pc
TB
QQB
NAMB
V Q KG
IQVB
VFB
KG
SMDKTB
LNB
Q Y P KdG
ALTAEB
IFB
N V KdddG
cc
KdG
L R T A KddG
ILNRTTB
LPNML
Pc
TB
QQB
NAMB
V Q KG
IQVB
VFB
c
Y I KG
SMDKTB
LNB
Q Y P KdG
ALTAEB
IFB
N V KdddG
c
YSFRDc
HTB
c
W H G KdG
cc
L R T A KddG
ILNRTTB
LPNML
Pc
TB
QQB
NAMB
V Q KG
IQVB
VFB
c
Y I KG
SMDKTB
LNB
Q Y P KdG
ALTAEB
IFB
N V KdddG
c
YSFRDc
HTB
c
W H G KdG
cc
L R T A KddG
ILNRTTB
LPNML
Pc
GB
LGB
QGMB
I E KG
IEVB
IYB
ccYY LT KG
SLDKTB
MTB
Q Y P KdG
SLQAHB
IFB
N V KdddG
ccYY SA YY KV NS ccPP LT BcBcWW HH GA KdG
cc
L R A A KddG
ILNRTTB
LPNNI
Pc
GB
ARB
RSIB
L Q KG
FEVB
LWB
KG
SLDRSB
LDB
T V P KdG
ELAPTB
LTB
R C KdddG
cc
KdG
L R A V KddG
IFQQMNB
MQPIN
Ec
PC
VNC
LCTC
I H JH
LTCC
TRC
c
Y W JH
VTGPPC
RVC
V Y D JIH
SMEADC
ILC
A V JIIIH
c
YTYRDc
GFC
c
W D A JIH
cc
L R S Y JIIH
VLQALGC
MPAHH
ccccc
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
c
c
cc cc cc c c
ccc c cc cccc
cccc
T
α8
α9
i. iiiiiiiiiiiiiiiiiii
iiiiii
TT
X
X
X
X
X
P DEEF
ccPP II FF ccPP PP NN DD ABRR .. DEEF
D S I L T DEEEEEEEEEEEF
LLLLSTc
LAc
DVYTVLA
R P DEEF
EFAIHGA
V N P M P G P DF
L T R DEEEEEF
AIARAAYV.....
P KddG
KddG
D S I L T KdddddddddddG
LLLLSTc
LAc
DVYTVLB
R P KddG
EFAMHGB
V N P M P W P KG
L T A KdddddG
AIARAAYV.....
P KddG
c
PIFc
PPNDB
R . KddG
D S I L T KdddddddddddG
LLPLSTc
LAc
DVYTVLB
R P KddG
EFAIHGB
V N P M P G P KG
L T R KdddddG
AIARAAYV.....
P KddG
ccPP II FF ccPP PP NN DD BBRR .. KddG
D S V L T KdddddddddddG
ILLLSTc
LAc
DVYSVLB
R P KddG
EFAIHGB
V N P M P G P KG
L T R KdddddG
AIARAAYA.....
P KddG
KddG
D S I L T KdddddddddddG
LLLLSTc
LAc
DVYTVLB
R P KddG
EFAIHGB
V N P M P G P KG
L T R KdddddG
AIARAAYV.....
P KddG
c
PIFc
PPNDB
R . KddG
D S I L T KdddddddddddG
LLLLSTc
LAc
DVYTVLB
R P KddG
EFAIHGB
V N P M S G P KG
L T R KdddddG
ATARAAYV.....
P KddG
c
PIYc
PPHDB
R . KddG
E N V L L KdddddddddddG
IILLSAc
LAc
DAFSVLB
A P KddG
DFNLFGB
V V P I Q G P KG
I N R KdddddG
AVAQNAYV.....
P KddG
ccPP IT FR ccPP PV TT EE BCRF N. KddG
E I V A Y KdddddddddddG
LLLVASc
LAc
DVYAALB
R P KddG
DFRMNGB
V V A P V G Q KG
I N R KdddddG
ALVLAAYH.....
Y JIIH
JIIH
R Q N L A JIIIIIIIIIIIH
IAILSRc
LFc
DVYSQWC
R L JIIH
RSTLQLC
R P K V L W W JH
L A H JIIIIIH
RLQAALRAFRLGR
ccccc cccMMMMMMMMM-MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMN
-c
c c c c cc
Bccccccc
B
ccccc cc
cc
βA
130
1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
180
1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
190
240
1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
300
1 vp7_btv10
vp7_btv1s
vp7_btv17
vp7_btv13
vp7_btv2a
vp7_btv1a
2 vp7_ehdv1
vp7_ahsv4
3 vp7_brd
acc
140
Alignment for protein VP7
150
200
250
310
260
320
160
170
210
220
230
270
280
290
330
340