Crossing the blood-brain barrier : the Brain

NEUREX EVENT
NE W S AND VI E WS F RO M I N D U S T RY
Crossing the blood-brain barrier :
the Brain Shuttle design
06 | 12th | 2014
Location:
Centre de neurochimie
5 Rue Blaise Pascal
Strasbourg
PROGRAM
Thursday June 12th
14.30
Ludovic COLLIN, PhD
Senior Scientist,
F. Hoffmann-La Roche Ltd.
The blood-brain barrier (BBB) prevents the passage of
large molecules from the bloodstream to the brain tissue. Researchers at the Hoffmann-La Roche institute
of Basel have developed a transferrin receptor-based
system, the Brain Shuttle, to increase the BBB penetration of an Aß-specific antibody into the brain of a
mouse model for Alzheimer’s disease.
On a broader range of application, the Brain Shuttle
Roche BS-Image_Credit
might be designed for the transport of a variety of molecules across the BBB, such as therapeutic growth
factors, enzymes and peptides.
Free registration and more info on www.neurex.org
European Regional
Development Fund
Partners: Program Interreg IV Upper Rhine "Transcending borders with every project", CNRS, INSERM, Université
de Strasbourg, Région Alsace, Département du Bas-Rhin, Département du Haut-Rhin, Communauté Urbaine de
Strasbourg, Bernstein Center Freiburg, Universität Freiburg, Universität Basel, Kanton Basel-Stadt, Kanton BaselLandschaft, Confédération Helvétique.
Reference: Niewoehner et al., 2014. Increased brain penetration and potency of
a therapeutic antibody using a monovalent molecular shuttle. Neuron, January 8.