Title of the offer: Post-doctoral position in Medicinal Chemistry
Title of the offer:
Post-doctoral position in Medicinal Chemistry, Montpellier
Welcoming Laboratory: UMR 5247 CNRS – University Montpellier 2
Nucleosides and Phosphorylated Effectors
Head of Team:
Professor C. Périgaud
Person in charge of the project: Dr S. Peyrottes
Post-doctoral position funded by an FRM grant, available for 12 months (eventually
renewable) and starting from April 2013.
Salary : ~1800 € net / monthly
The aim of the present project is to better understand the mechanism of Vγ9Vδ2 T cell
activation at the molecular and cellular levels and to use the acquired knowledge for the
analysis of these T cells in the course of immune response to viral infections and/or cancers.
The project requires the synthesis of a small library of nucleotide derivatives. This is certainly
the most challenging issue; indeed despite an increasing demand for phosphorylated
biological tools, their synthesis and purification is still complex, expensive and timeconsuming. To this end a novel synthetic methodology involving supported chemistry will be
The candidate will join the academic team (10 persons) and be involved in the development of
the synthetic methodology as well as the design of the nucleotide’s library in relation with the
biologist team. We are seeking for a highly-qualified and motivated postdoctoral fellow.
Additional Information can be gleaned at (http://www.ibmm.univ-montp1.fr/NucleosidesEffecteurs,415.html)
The following points are considered mandatory:
The applicant should hold a Ph.D. for less than 3 years.
The applicant should have a well-established experience in medicinal and organic
chemistry; knowledge in the field of organophosphorus and/or nucleoside
chemistry, eventually supported synthesis, will be required.
Experience in synthesis and purification of phosphorylated biomolecules, NMR
(1H, 13C and 31P), HPLC, and LC-MS/MS.
Languages: English and/or French
Please send your application by e-mail only ([email protected]) including a CV, list
of publications and at least 3 references before March 20th, 2013, indicating in the subject of
the message “For the attention of Dr S. Peyrottes”