Response to Letter by Hnid

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Table 2.
Response to Letter by Hnid
Intima Media Thickness Predictors (nⴝ183)
Response:
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As pointed out by Dr Hnid, men were significantly more
frequently smokers/past smokers as compared with women. As
mentioned in the statistic section,1 the multivariate models with
the memory score as the dependent variable tested the association with tobacco use, which was not found significant either in
the whole study population or in men only. In the discussion, we
also reported that “male gender was the strongest independent
predictor of PWV in multivariate analysis (data not shown),
which may contribute to the differential association of PWV with
the cognitive decline regarding gender.” These multivariate models
also included tobacco use, which was not found significantly
associated with either pulse-wave velocity (PWV) or intima
media thickness, or flow-mediated dilation (see subsequently;
Tables 1 to 3).
Finally, as stated in the discussion, “In our present study, an
association between AS and memory impairment was only
observed in men suggesting possible differential effects in
hypertensive patients of gender at an early stage of cognitive
impairment,” “Prospective studies are required to determine
whether such a gender-specific pattern may influence the transition from SMC to dementia,” and “The observational study
design does not allow the ascertaining of causality.”
P
Percent of
Variance Explained
Male gender
1.707⫾0.320
⬍0.0001
15%
Age per 5 years
0.722⫾0.126
⬍0.0001
11%
24-hour SBP per
10 mm Hg
0.31⫾0.13
0.017
3%
Low-density lipoprotein
cholesterol, g/L
1.080⫾0.478
0.025
1%
Fasting glucose, g/L
1.834⫾0.606
0.003
4%
0.222⫾0.050
⬍0.0001
9%
24-hour SBP per
10 mm Hg
0.11⫾0.05
0.032
2%
0.032
2%
Table 3.
⫺0.321⫾0.149
Flow-Mediated Dilation Predictors (nⴝ162)
Parameter
Left ventricular
hypertrophy
Regression
Coefficient⫾SE
P
Percent of
Variance Explained
⫺4.379⫾1.451
0.003
5%
R2⫽5%; P⫽0.003.
tein cholesterol, triglycerides, fasting glucose, diabetes, current or past smoking, folates, von Willebrand, angiotensinconverting enzyme inhibitor, angiotensin receptor blocker,
diuretics, calcium channel blockers, ␤-blockers, other antihypertensive drugs, and anticoagulants using the same statistical
procedures described in “Methods” in our article.
Disclosures
None.
Anna Kearney-Schwartz, MD
Patrick Rossignol, MD, PhD
Inserm 9501 Clinical Investigation Centre
Dommartin lès Toul, France
Nancy University Hospital
J. d’Arc Hospital
Dommartin lès Toul, France
Inserm U961
Faculty of Medicine
Nancy, France
Nancy University
Nancy, France
Pulse-Wave Velocity Predictors (nⴝ173)
Regression
Coefficient⫾SE
Percent of
Variance Explained
R2⫽13%; P⬍0.0001.
SBP indicates systolic blood pressure.
To determine which parameters were associated with PWV,
intima media thickness (Table 2), and flow-mediated dilation
(Tables 1 and 3), we performed multivariate analyses, including gender, age, body mass index, 24-hour systolic blood
pressure, diastolic blood pressure, estimated glomerular filtration rate, microalbuminuria (⬍30 versus ⱖ30 mg/24
hours), left ventricular hypertrophy, intima media thickness,
PWV (as appropriate), total cholesterol, low-density lipopro-
Parameters
P
Age per 5 years
Angiotensin-converting
enzyme inhibitor
Multivariate Analyses of PWV, Intima Media
Thickness, and Flow-Mediated Dilation Predictors
Table 1.
Regression
Coefficient⫾SE
Parameters
Serge Bracard, MD
Neuroradiology Service
Nancy University Central Hospital
Nancy, France
Nancy University
Nancy, France
R ⫽34%; P⬍0.0001.
SBP indicates systolic blood pressure.
2
A.K.-S. and P.R. contributed equally to this article and are cofirst authors.
(Stroke. 2009;40:e540-e541.)
© 2009 American Heart Association, Inc.
Stroke is available at http://stroke.ahajournals.org
DOI: 10.1161/STROKEAHA.109.557389
e540
Letters to the Editor
Jacques Felblinger, PhD
Inserm ERI 13
Adaptive, Diagnostic and Intervention Imagery
CIC–Innovative Technologies
Brabois Hospital
Vandoeuvre lès Nancy
Nancy, France
Nancy University
Nancy, France
Renaud Fay
Inserm 9501 Clinical Investigation Centre
Dommartin lès Toul, France
Nancy University Hospital
J. d’Arc Hospital
Dommartin lès Toul, France
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Jean-Marc Boivin, MD
Inserm 9501 Clinical Investigation Centre
Dommartin lès Toul, France
Nancy University Hospital
J. d’Arc Hospital
Dommartin lès Toul, France
Nancy University
Nancy, France
Thomas Lecompte, MD
Clinical Research–Clinical Laboratories Department
Haemostasis Unit (Biological Haematology Department)
Nancy University Brabois Hospital
Vandoeuvre lès Nancy, France
Inserm, U961
Faculty of Medicine
Nancy, France
e541
Nancy University
Nancy, France
Patrick Lacolley, MD, PhD
Inserm, U961
Faculty of Medicine
Nancy, France
Nancy University
Nancy, France
Athanase Benetos, MD, PhD
The Geriatric Service
Nancy University Brabois Hospital
Vandoeuvre lès Nancy, France
Inserm, U961
Faculty of Medicine
Nancy, France
Nancy University
Nancy, France
Faiez Zannad, MD, PhD
Inserm 9501 Clinical Investigation Centre
Dommartin lès Toul, France
Nancy University Hospital
J. d’Arc Hospital
Dommartin lès Toul, France
Inserm U961
Faculty of Medicine
Nancy, France
Nancy University
Nancy, France
1. Kearney-Schwartz A, Rossignol P, Bracard S, Felblinger J, Fay R, Boivin
JM, Lecompte T, Lacolley P, Benetos A, Zannad F. Vascular structure and
function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints.
Stroke. 2009;40:1229 –1236.
Response to Letter by Hnid
Anna Kearney-Schwartz, Patrick Rossignol, Serge Bracard, Jacques Felblinger, Renaud Fay,
Jean-Marc Boivin, Thomas Lecompte, Patrick Lacolley, Athanase Benetos and Faiez Zannad
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Stroke. 2009;40:e540-e541; originally published online August 6, 2009;
doi: 10.1161/STROKEAHA.109.557389
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