New algrithm for library-based pyrosequencing signal analysis

Liaison Entreprises et Universités
Université catholique de Louvain
New algrithm for library-based pyrosequencing signal
analysis
Informatique et science de l'information, Sciences biologiques, Biotechnologie médicale
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Pyrosequencing, Multiplex signal analysis, metagenomics, Oncogene re-sequencing
Questions ?
Sébastien ADAM
Expert valorisateur Région wallonne - Nanotechnologies,
Technologies de l'Information et de la Communication
 +32-010472443
 [email protected]
Description
The Louvain Technology Transfer Office of the Université catholique de Louvain (UCL) presents a new algorithm for librarybased pyrosequencing signal analysis.
The UCL invention relates to a new approach for the analysis of pyro-sequencing signals. It comprises new methods for
analyzing pyrosequencing signals in a fast, reliable, and automated way.
Potential applications and advantages
More information about the Universities & Higher Education Institutions expertise on www.reseaulieu.be
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Liaison Entreprises et Universités
Potential applications and advantages
The algorithm developed by UCL team is dedicated to the processing of:
1. Multiplex signals analysis in a single biosample
The algorithm allows identifying multiple SNPs from the same biosample. The algorithm is generic and can therefore be used in
various applications:
Genotyping polymorphisms in pharmacogenetics
Identification of bacterial antibiotic resistance due to gene mutation
2. Multiple signals analysis from metagenomics
The algorithm allows interpreting pyrosequencing signals generated by a community of micro-organisms. It can therefore be used
for various identifications:
Identification of bacteria/ and mycobacteria species
Identification of virus species
3. Analysis of pharmaco-oncogenetics or somatic mutations
The generic algorithm can be applied to identify somatic mutations in numerous oncogenic targets: EGFR – KRAS – NRAS BRAF.
The new algorithm is characterized by high sensitivity (low Limit of Detection) and flexibility (high number of mutations).
The new algorithm is particularly suitable for difficult samples (Formalin Fixed Paraffin Embedded) and provides rapid and easily
interpretable results.
Patent
This work is the subject of:
a UK patent application filed on the 2nd of May, 2013 (GB 1307913.2)
a PCT patent application filed on the 30th of April 2014 (PCT/EP2014/058793)
Stage of development
Advance Stage
Type of collaboration
Licence Agreement
More information about the Universities & Higher Education Institutions expertise on www.reseaulieu.be
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