presentation et programme 2011-2012

M2 Recherche :
Sciences du médicament
Skin Delivery
Responsable : Professeur Françoise FALSON
Tel : 04.78.77.71.11 / Fax : 04.78.77.72.47
[email protected]
PRESENTATION ET PROGRAMME 2011-2012
 Présentation des UE
UE1 Propriété intellectuelle des médicaments, Documentation scientifique
UE2 Mathématiques et Statistiques
UE11 Absorption cutanée et formulation
UE16 Physiologie et biodisponibilités cutanées
UE17 Formulation pratique et tests d’activité
UE Initiation à la recherche
UE Stage
 Planning
UE1
UE2
UE11
UE16
UE17
UE Initiation à la recherche
UE Stage
Examens
Semaine 42 et 11/10/2011
Semaines 44, 45 et 46
Semaine 40
Semaine 41
Semaine 43
Semaine 47
Semaines 01 à 26
Semaine 50
3 ECTS
3 ECTS
6 ECTS
6 ECTS
6 ECTS
6 ECTS
30 ECTS
EMPLOI DU TEMPS
UEs 11 et 16
European Lifelong Learning Program/Erasmus Intensive Program
“Advanced Delivery Strategies for Pharmaceutics and Cosmetics”
Lyon 3rd - 14th October 2011
From the 3rd to the 7th, the conferences will take place at:
ISPB – Faculty of Pharmacy - Salle du Conseil – Level 1, Stair A
3rd - 4th October Session I:
Skin delivery
rd
Monday, October 3 , 2011
9 – 10 am
Welcome and Presentation
10 – 11 am
Marek Haftek – University of Lyon – Normal and pathological functions of the skin
barrier
11 – 12
Fabrice Pirot – University of Lyon – Transcutaneous gas exchanges
12 - 2 pm
Lunch break
2 – 3 pm
Anne Sirvent – Laboratoire Dermscan – Safety and efficacy evaluation of products in
vivo in man
3 – 4 pm
Fabrice Pirot – University of Lyon – Current and new strategies for antimicrobial skin
delivery
Tuesday, October 4th , 2011
10 – 11 am
Estelle Tessonneaud and Nathalie Seyler – Episkin – Reconstructed skin evaluation
research tools
11 – 12
Valérie Bertholle – University of Lyon – Skin cancers
12 - 2 pm
Lunch break
2 – 3 pm
Yogeshvar Kalia – University of Geneva – Iontophoresis: Delivering charged molecules
across biological membranes; Part 1 Principles, transport mechanisms and effect on skin
3 – 4 pm
Yogeshvar Kalia – University of Geneva – Iontophoresis: Delivering charged molecules
across biological membranes; Part 2 Clinical applications - Case studies for local and systemic delivery
and therapeutic monitoring
4 – 5 pm
Steffi Hansen – University of Saärbrucken – In vitro studies, Methodology for skin
absorption
5th - 6thOctober Session II:
Drug development, Formulation
Wednesday, October 5th , 2010
9 – 10 am
Laurène Roussel – University of Lyon – Surfactants as skin penetration modulators
10 – 11 am
Mirjana Gasperlin – University of Ljubljana - Microemulsions
11 – 12
Marie-Geneviève Dijoux – University of Lyon – New drugs from plants
12 - 2 pm
Lunch break
2 – 3 pm
Laëtitia Cattuzzato – Seppic 3 – 5 pm
Helena Marques – University of Lisboa – Cyclodextrins in drug development and
formulation
Thursday, October 6th, 2010
9 – 10 am
10 – 11 am
Daniel Kurbiel – Polaar - The development process of a polar concept cosmetic range
11 – 12
Frédéric Thareau – Polaris – Technical approach for high potency healthcare and
skincare ingredients
12 - 2 pm
Lunch break
2 – 3 pm
Nicolas Atrux-Tallau – Capsum - Nanoemulsions
3 – 4 pm
Françoise Falson – University of Lyon – Skin absorption modulation
4 – 5 pm
Jean-François Nicolas – University of Lyon – Skin immune system
7th October Session III:
Pulmonary delivery
th
Friday, October 7 , 2010
9 – 10.30 am Carsten Ehrhardt – Trinity college, Dublin - Anatomy and physiology of the
respiratory tract
10.30 – 12
Fabio Sonvico – University of Parma – Drug delivery to the lung
12 - 2 pm
Lunch break
2 – 3.30 pm
Carsten Ehrhardt – Trinity college, Dublin - In vitro models of respiratory drug
delivery
3.30 – 5 pm
Fabio Sonvico – University of Parma – Nanoparticles as pulmonary drug delivery
systems
From the 10th to the 14th, the laboratory sessions will take place in different locations,
please refer to the laboratory session document.
10th - 14th October Laboratory Sessions
Monday, October 10th , 2011
8 – 11
Chlorhexidine gel, formulation and microbiology (part 1)
11 – 12
Jean Freney – University of Lyon – Skin microflora
12 - 2 pm
Lunch break
2 – 5 pm
Transdemal delivery system, formulation (part 1)
Wednesday, October 12th , 2010
9 – 10 am
Chlorhexidine gel, microbiology (part 2)
10 – 12
Confocal microscopy (part 1) – Yves Tourneur
12 - 2 pm
Lunch break
2 – 4 pm
Confocal microscopy (part 2)
4 – 6 pm
Audrey Guéniche - L’Oréal Thursday, October 13th, 2010
9 – 12
12 - 2 pm
2 – 6 pm
Anne-Cécile Dontot – Seppic Lunch break
Stéphane Lebras - Thermo Electron -
Friday, October 14th, 2010
9 – 12
Transdermal delivery system (part 2)
12 - 2 pm
Lunch break
2 – 6 pm
Transdermal delivery system (part 3)
UE 1
Conférence inaugurale:
Marc LE BORGNE
18 octobre 2011, 10h-12h
Salle du Conseil
Conférences INPI:
Céline MATHEVET
Ines TRIPOZ
Carole BREMEERSCH
Guillaume BRUNEL
18 octobre 2011, 14h-16h
19 octobre 2011, 10h-12h
20 octobre 2011, 10h-12h
21 octobre 2011, 10h-12h
Salle du Conseil
Salle du Conseil
Salle du Conseil
Salle des thèses 1
Travaux dirigés :
- Séance 1 : méthodes de base et applications et Séance 2 : bases de données de référence
Pascal BADOR
11 octobre 2011
Salle informatique
- Séance 3 : accès aux brevets
Laurent ETTOUATI
21 octobre 2011, 14-16h
Salle informatique
- Séance 4 : logiciels scientifiques
Laurent ETTOUATI
20 octobre 2011, 14h-16h
Salle informatique
- Séance 5 : rédaction scientifique et démarrage du TPE
Pascal BADOR
date à définir
Salle informatique
UE 17
From the 24th to the 28th, the laboratory sessions will take place at:
Salle de TP du Laboratoire de Pharmacie Galénique – Level 2, Stair C
Monday, October 24th , 2011
9.30 – 12
Lectures:
Emulsions and Gels
Introduction to Rheology
12 - 2 pm
Lunch break
2 – 6 pm
Formulation of ternary diagram (oil, water, surfactant)
Tuesday, October 25th , 2011
9 – 12
Difference of UV transmittance through stratum corneum in different ethnic
skins
12 - 2 pm
Lunch break
2 – 6 pm
Skin hydration: Comparison between Emulsion and Microemulsion
Wednesday, October 26th , 2010
9 am – 6 pm Formulation and characterization of tanning effect of Dihydroxyacetone loaded
liposomes (proliposomes) and Ethosomes
Thursday, October 27th, 2010
9 am – 6 pm Formulation and rheological characterization of a topical preparation
containing cafeine
Friday, October 28th, 2010
9 am – 6 pm Formulation and characterization of sun products
UE 2
Monday, October 31st, 2011
10-12
MA Dronne
Lecture and exercises:
Mathematical functions and differential equations
Wednesday, November 2nd, 2011
2-4pm
MA Dronne
Lecture and exercices:
Population pharmacokinetics and Pharmacodynamics
Thursday, November 3rd, 2011
2-4 pm
C Bardel
Lecture and exercises:
Experimental design, descriptive statistics
Friday, November 4th, 2011
2-4 pm
C Bardel
Lecture and exercises:
Parametric hypothesis tests for the means, the proportions and
the variances
Monday, November 7th, 2011
2-4 pm
C Bardel
Lecture and exercises:
Analysis of variance (ANOVA)
Wednesday, November 9th, 2011
2-4 pm
MA Dronne
Lecture and exercises:
Nonparametric hypothesis tests
Tuesday, November 15th, 2011
8-10am
MP Gustin
Lecture and exercices:
Linear regression, correlation, calibration curves
2-4 pm
MP Gustin
Lecture:
Initiation to statistical multivariate analysis, application to
release kinetics
Wednesday, November 16th, 2011
2-5 pm
MP Gustin
Salles informatique 3 and 4
Practice:
Linear regression, correlation, calibration method
Friday, November 18th, 2011
2-5 pm
MP Gustin
Salles informatique 3 and 4
Statistical practice in pharmaceutics (recap) (MP Gustin)
UE Initiation à la recherche
21, 23, 24 et 25 Novembre 2011