CV L Legeai Mallet

Laurence Legeai-Mallet
DR2 INSERM
INSERM U781
Hôpital Necker-Enfants Malades
149 rue de Sèvres
75015-Paris
+33 1 71 19 63 05
[email protected]
Interests
Identification of disease genes involved in cartilage and bone diseases
Understanding bone development and FGFR3-related skeletal diseases
Therapeutic approaches for achondroplasia and hypochondroplasia.
Background and professional experience
2005-2013: Team leader « Molecular basis and pharmacological approaches of FGFR3-related
chondrodysplasias
2010-: Director of Research (DR2)-INSERM
2005: Habilitation à diriger des recherches, University ParisV
2002: Research fellow (CR1)-INSERM
1997-PhD-Human Genetics, University ParisV
1986- Graduate Engineer CNAM –speciality biology
Five selected publications
Selected publications in the field of FGFR3-related chondrodysplasias
Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating
Achondroplasia. Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ,
Bell SM, Bullens S, Bunting S, Tsuruda LS, O'Neill CA, Di Rocco F, Munnich A, Legeai-Mallet L.
Am J Hum Genet. 2012 Dec 7;91(6):1108-14.
An activating Fgfr3 mutation affects trabecular bone formation via a paracrine mechanism during
growth. Mugniery E, Dacquin R, Marty C, Benoist-Lasselin C, de Vernejoul MC, Jurdic P, Munnich A,
Geoffroy V, Legeai-Mallet L. Hum Mol Genet. 2012 Jun 1;21(11):2503-13.
Jonquoy A, Mugniery E, Benoist-Lasselin C, Kaci N, Le Corre L, Barbault F, Girard AL, Le Merrer
Y, Busca P, Schibler L, Munnich A, Legeai-Mallet L. A novel tyrosine kinase inhibitor restores
chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model.
Hum Mol Genet. Hum Mol Genet. 2012 Feb 15;21(4):841-51.
Pannier S, Mugniery E, Jonquoy A, Benoist-Lasselin C, Odent T, Jais JP, Munnich A, Legeai-Mallet
L. Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia. Bone. 2010 , 47 :
905-915.
Schibler L, Gibbs L, Benoist-Lasselin C, Decraene C, Martinovic J, Loget P, Delezoide AL, Gonzales
M, Munnich A, Jais JP, Legeai-Mallet L. New insight on FGR3-related chondrodysplasias molecular
physiopathology revealed by human chondrocyte gene expression profiling. PLoS One. 2009 29;4, 10.