Laferrière B 23_10_2012 ANNONCE
Transcription
Laferrière B 23_10_2012 ANNONCE
CPER Cardio-diabète Diabète : du syndrome métabolique aux complications vasculaires Conférence Mardi 23 octobre 2012 – 11h Amphi B Faculté de Médecine, Pôle Recherche, 3ème étage Place de Verdun - Lille (métro ligne 1 CHR Oscar Lambret) Dr. Blandine Laferrère Columbia University College of Physicians and Surgeons, NY, USA Diabetes Remission after weight loss surgery: is it just weight loss? Summary : Bariatric surgery results in weight loss of great magnitude and sustained overtime, with remarkable improvement and/or remission of type 2 diabetes. The favorable change in the incretin gut hormones after gastric bypass surgery (GBP) is thought to be responsible, in part, for diabetes remission after GBP, independent of weight loss. After GBP, the post-prandial incretin hormones plasma concentrations increase by 3-5 fold and the blunted incretin effect on insulin secretion improves rapidly in patients with diabetes. In addition to changes in incretins, insulin secretion and glucose levels, circulating branched chain amino acid, know to be associated with insulin resistance, decrease more after GBP compared to diet. Bile acids and microbiota may also play a role in the improvement of glucose metabolism after GBP. The relative role of weight loss and of bypass will be discussed. Understand the mechanisms by which diabetes improves after GBP and may help develop less invasive treatment options for obesity and diabetes. A l’invitation du Pr François Pattou, UMR 859 « Biothérapie du diabète » Comité de suivi et de coordination - Prs. Philippe Froguel, François Pattou, Bart Staels ; Contacts : [email protected]