The squalenoylation of vitamine C: a skin anti

The squalenoylation of vitamine C: a
skin anti-aging formulation
CONTEXT
Our reference :
04770-01
Status des brevets
French patent
application FR1252382
filed on March 16th,
2012.
The ascorbic acid (Vit C) is an anti-oxydant compound which helps to the production of
collagene and is an essential compound for the formation of the conjonctive tissue of the
skin. It is recognized that this compound should theoretically improve the esthetic aspect
of the skin. However, the penetration of Vit C into the skin is hampered by its hydrophilic
character and this molecule is subject to fast degradation due to oxidation. The team has
developed a new formulation of Vit C, able to overcome the above disadvantages, by
chemical linkage with the squalene, a natural and biocompatible lipid.
TECHNICAL DESCRIPTION
We have discovered that the linkage of squalene, a natural and biocompatible lipid, to Vit
C permitted the spontaneous formation of nanoassemblies in a water medium.
Interestingly, the Vit C-squalene bioconjugate may also be mixed with pure squalene to
obtain a nice and homogeneous gel that can be applied onto the skin. Comparatively to
pure Vit C, a better anti-aging activity has been obtained on human skin explants.
Inventors
Patrick COUVREUR
Fatima ZOUHIRI
Ruxandra GREF
Didier DESMAELE
DEVELOPMENT STAGE
Synthesis and characterization of squalene-based vitamine C gels and
nanoparticles
In vitro efficacy assays on human skin
In vitro safety on human fibroblasts
BENEFITS
Status Commercial
Exclusive or non
exclusive licenses
The squalenoylated vitamine C is able: (i) to protect the vitamine from oxydation, (ii) to
enhance neutral GAGs expression, (iii) to enhance collagene III production and (iii) to
induce both dermal and epidermal stimulation without cytotoxicity.
INDUSTRIAL APPLICATIONS
This discovery may be commercialized by the cosmetic industry as anti-aging cream.
Laboratoires
For further information, please contact us (Ref 04770-01)
Institut GALIEN,
Université Paris-Sud
Keywords :
Vitamine C. Squalene
Nanoparticles Gel Skin
protection Anti-aging
Dermatological
formulation
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