Morgan Craig, Ph.D. - Scholars at Harvard

Morgan Craig, Ph.D. - Scholars at Harvard

Morgan Craig, Ph.D.
Contact
Information
Room 640, 1 Brattle Square
Program for Evolutionary Dynamics
Harvard University
Cambridge, MA 02138 USA
[email protected]
scholar.harvard.edu/morgancraig
Research
Interests
Mathematical modelling of biological phenomena, quantitative systems pharmacology, dynamical
systems, stochastic influences on biological systems
Education
Université de Montréal, Montréal, QC Canada
Ph.D. (Pharmaceutical sciences), 2016
• Dissertation title: Improving the use of G-CSF during chemotherapy using physiological mathematical modelling: a quantitative systems pharmacology approach
• Supervisors: Fahima Nekka (Université de Montréal), Michael C Mackey (McGill University)
University of Manitoba, Winnipeg, MB Canada
M.Sc (Mathematics), 2011
• Thesis title: Incorporating stochastic influences in assembly models: application to intermediate filament polymerisation
• Supervisor: Stéphanie Portet (University of Manitoba)
Collège universitaire de Saint-Boniface, Winnipeg, MB Canada
B.Sc. (Mathematics and chemistry), 2006
Employment
Postdoctoral Research Fellow, March 2016-present
Program for Evolutionary Dynamics
Harvard University, Cambridge, MA
Publications
1. Craig, M., Humphries, A.R., Mackey, M.C. (2016). A mathematical model of granulopoiesis
incorporating G-CSF/neutrophil binding and internalisation kinetics. Bulletin of Mathematical
Biology, 78(12). 2304–2357.
2. Craig, M., Humphries, A.R. and Mackey. M.C. (2016). An upper bound for the half-removal
time of neutrophils from circulation. Blood, 128(15). 1989–1991.
3. Craig, M., Gonzalez-Sales, M., Li, J., Nekka, F. (2016). Approaching pharmacometrics as a
paleontologist would: recovering the links between drugs and the body through reconstruction.
Clinical Pharmacology and Therapeutics: Pharmacometrics and Systems Pharmacology, 5. 158–
160.
4. Craig, M., Gonzalez-Sales, M., Li, J., Nekka, F. (2016). Investigating the impact of pharmacokinetic variability on fully-mechanistic models: case study of neutrophil development, PM00104, and
filgrastim. In: Toni, B. (ed.) Mathematical Sciences with Multidisciplinary Applications. Springer
Proceedings in Mathematics and Statistics. Springer Science + Business Media, New York. 91–
112.
5. Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2015). Neutrophil dynamics
during concurrent chemotherapy and G-CSF administration: mathematical modelling guides dose
optimisation to minimise neutropenia. Journal of Theoretical Biology, 385. 77–89.
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Papers under
review
1. Craig, M. (2016). Towards quantitative systems pharmacology models of chemotherapy-induced
neutropenia. CPT: Pharmacometrics & Systems Pharmacology (invited review).
2. Langlois, G.P., Craig, M., Humphries, A.R., Mackey, M.C., Mahaffy, J.M., Blair, J., Moulin, T.,
Sinclair, S.R. and Wang, L. (2016). Normal and pathological dynamics of platelets in humans.
Journal of Mathematical Biology. http://arxiv.org/abs/1608.02806.
Abstracts
1. Craig, M., Gonzalez-Sales, M., Li, J., Nekka, F. (2015). The robust response of a physiological
model of granulopoiesis to PK variability. Journal of Pharmacokinetics and Pharmacodynamics,
42. S33.
2. Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). Physiologically-based
mathematical modelling of neutrophil dynamics during concurrent chemotherapy and filgrastim
support. Blood, 124. 5134.
3. Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). Mechanistic-based
translational model for the optimisation of the concurrent administration of chemotherapy and
filgrastim. Journal of Pharmacokinetics and Pharmacodynamics, 41. S99.
Conference
Presentations
and Posters
Invited
Craig, M. (2016). Physiological determinants of the PKs of G-CSF: mechanistic modelling of granulopoiesis. Pfizer Systems Modelling and Simulation, Cambridge, MA, USA.
Craig, M. (2016). Mechanistic mathematical modelling in hematology: granulopoiesis and the negative feedback interactions of G-CSF and neutrophils. Fred Hutchinson Cancer Research Center,
Seattle, WA, USA.
Craig, M., Humphries, A.R., Mackey, M.C. (2016). Determining a PK model for G-CSF using
physiology as a basis: the cytokine paradigm and internalisation dynamics. American Conference on
Pharmacometrics 7, Seattle, WA, USA.
Craig, M., Humphries, A.R., Mackey, M.C. (2016). Granulopoiesis physiology determines the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF). SIAM Conference on the Life Sciences, Boston, MA, USA.
Craig, M. (2015). Diagnosing and predicting cyclic neutropenia: an online solution for clinicians
and modellers alike. American Conference on Pharmacometrics 6, Washington, D.C., USA.
Craig, M., Gonzalez-Sales, M., Li, J., Nekka, F. (2015). Investigating the impact of pharmacokinetic
variability on physiological models with delays: a case study of neutrophil development, Zalypsis, and
figrastim. AMMCS-CAIMS 2015 Special Session on Delay Differential Equations as Mathematical
Models of Real World Phenomena, Wilfrid Laurier University, Waterloo, ON, Canada.
Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). A physiologically-based
model of granulopoiesis to guide dosing regimens in oncology. CAMBAM Seminar Series, McGill
University, Montréal, QC, Canada.
Contributed
Craig, M. (2016). Regimen optimisation of filgrastim support during periodic chemotherapy using
physiological PK/PD modelling. Fields Institute Workshop on Mathematical Oncology VI, Toronto,
ON, Canada.
Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). Construction of a
physiological model of myelopoiesis with PKPD models for the design of optimal dosing regimens of
chemotherapy with G-CSF Support. SIAM Conference on the Life Sciences, Charlotte, NC, USA.
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Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2013). Pharmacokinetic and
pharmacodynamic modelling of G-CSF post-docetaxel administration. Society for Mathematical Biology Annual Meeting, Phoenix, AZ, USA.
Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2012). Pharmacokinetic /pharmacodynamic modelling of the administration of G-CSF during anti-cancer treatments. CAMBAM
Annual General Meeting, McGill University, Montréal, QC, Canada.
Craig, M. and Portet, S. (2010). Une approche probabiliste pour les systèmes réactionnels. Journée
de savoir, CUSB, Winnipeg, MB, Canada.
Craig, M. and Portet, S. (2008). Effet des changements climatiques sur la population des requins
baleines de Ningaloo Reef, Australie. Journée du savoir, CUSB, Winnipeg, MB, Canada.
Craig, M. and Bagayogo, A. (2006). La simulation numérique des phénomènes réels sur ordinateurs.
Journée du savoir, CUSB, Winnipeg, MB, Canada.
Posters
Craig, M., Gonzalez-Sales, M., Li, J., Nekka, F. (2015). The robust response of a physiological model
of granulopoiesis to PK variability. American Conference on Pharmacometrics 6, Washington, D.C.,
USA.
Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). Physiologically-based
modelling of granulopoiesis during concurrent chemotherapy and filgrastim support. Rendez-vous
de la recherche pharmaceutique de la Faculté de pharmacie, Université de Montréal, Montréal, QC,
Canada.
Craig, M., Humphries, T., Bélair, J., Li, J., Nekka, F., Mackey, M. (2014). Physiologically-based
modelling of granulopoiesis during concurrent chemotherapy and filgrastim support. American Conference on Pharmacometrics 5, Las Vegas, NV, USA.
Craig, M. and Portet, S. (2009). Modelling the possible effects of climate change on a population of
whale sharks. NSERC Undergraduate Poster Competition, University of Manitoba, Winnipeg, MB,
Canada.
Teaching and
Advising
Supervision
• Tyler Cassidy (Doctoral program, McGill University), unofficial co-supervision, 2016–present
• Christopher Bruno (Undergraduate program, Harvard University), 2016–present
Lectureships
• Chargée de cours. Statistiques appliquées aux sciences biopharmaceutiques (Université de Montréal).
67 students, 2015.
• Chargée de cours. Statistiques appliquées aux sciences biopharmaceutiques (Université de Montréal).
67 students, 2014.
Course Assistantships
• Auxiliaire de cours. Mathématiques pour chimistes (Université de Montréal). 59-79 students per
session, 2012-2015.
• Auxiliaire de cours. Statistiques appliquées aux sciences biopharmaceutiques (Université de Montréal).
74 students, 2013.
• Assistante de cours. Géométrie vectorielle et algèbre linéaire, Introduction au calcul, Calcul II,
Analyse statistique de base I & II (Collège universitaire de Saint-Boniface), 30-70 students per
session, 2006-2011.
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Honours and
Awards
Federal Funding
• Postgraduate Scholarship–Doctoral Program, Natural Sciences and Engineering Research Council
of Canada, 2011-2014
• Michael Smith Foreign Study Supplement, Natural Sciences and Engineering Research Council
of Canada, 2010
• Postgraduate Scholarship–Masters Program, Natural Sciences and Engineering Research Council
of Canada, 2009-2010
Institutional Support
• Postdoctoral Award for Professional Development, Harvard University, 2016
• Bourse de fin d’études doctorales, Université de Montréal, 2015
• Prix du vice-décanat, Faculté de pharmacie–Université de Montréal, 2015
• Bourse J.A. de Sève, Faculté des études supérieures et postdoctorales–Université de Montréal,
2015
• Dr. Narain Gupta Scholarship in Mathematics, Department of Mathematics–University of Manitoba, 2009-2010
• Student Research Award, Faculty of Science–University of Manitoba, 2008
• Médaille d’excellence, Collège universitaire de Saint-Boniface, 2006
• Bourses d’excellence, Collège universitaire de Saint-Boniface, 2003-2006
Travel Grants
• SIAM Conference on Dynamical Systems, 2016
• Travel Scholarship, AMMCS-CAIMS, 2015
• Landahl Travel Grant, Society for Mathematical Biology, 2013
Distinctions
• Prix Lionel-Fréchette, Collège universitaire de Saint-Boniface, 2003
• Dean’s Honour List, Collège universitaire de Saint-Boniface, 2003-2006
Professional
Affliations
International Society of Pharmacometrics, 2015-present
American Society of Clinical Oncology, 2014-present
Society for Mathematical Biology, 2013-present
Society for Applied and Industrial Mathematics, 2013-present
Professional
Service
Conference Session Organiser
• Mathematical Modeling and Healthcare Applications. With support from the IMU Committee
for Women in Mathematics. Pfizer, Cambridge, MA. 2017 (submitted).
• Dynamical Systems at the Interface of Medicine and Interventions. SIAM Conference on Dynamical Systems 2017, Snowbird UT, USA. 2017 (submitted).
• Translational Therapeutics Aspects of Computerized Platforms: Web, Mobile and Wearable Solutions for the Drug R&D and Clinical Use. Banff International Research Station, Banff, AB,
Canada. Co-organised with Fahima Nekka (Université de Montréal), Philippe Robaey (University
of Ottawa), and Olivier Barrière (inVentiv Health). 2017.
• Better Medicine Through Mathematics. SIAM Conference on the Life Sciences 2016, Boston
MA, USA. Co-organised with Michael Mackey. 2016.
Journal Reviewer
• Journal of Theoretical Biology
• European Journal of Clinical Pharmacology
• Mathematics and Computers in Simulation
• Mathematical Biosciences
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Conference Abstracts Reviewer
• American Conference on Pharmacometrics 7
Committee Member
• CAMBAM student representative, 2014-2015
• CAMBAM student chapter organiser, 2012-2016
• Représentante du comité des bibliothèques, Conseil des étudiants du cycle supérieur en pharmacie, 2014-2015
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