Plasma-levels-of-brain-derived-neurotrophic-factor-BDNF

Plasma levels of brain-derived neurotrophic factor (BDNF) and urocortin-1 in
women with pelvic pain associated or not associated with endometriosis.
Abstract ID : 1761
Soumis par : Fernando Reis Le 2016-03-15 23:40:35
Nom de la catégorie : SEUD CONGRESS
Typologie : Communication orale / Oral communication
Statut : validé
Autorisation de diffusion : Yes/Oui
------------------------------------INTRODUCTION: Brain-derived neurotrophic factor (BDNF) and urocortin-1 (Ucn1) are neuropeptides found in human
peripheral plasma and associated with complex behavioral responses to physical injury and chronic stress.
Endometriosis is a chronic, painful, inflammatory condition that alters the plasma levels of many signaling molecules,
such as cytokines and hormones, but the use of these molecules as diagnostic markers for endometriosis has been
hampered by their nonspecific increase in women with other pain syndromes or inflammatory diseases. Therefore, a
persisting challenge in endometriosis research is to pursue a biomarker that changes in endometriosis but not in other
forms of pelvic pain. The aim of this study was to test whether plasma levels of BDNF and Ucn1 are useful to predict the
presence of endometriosis in women with pelvic pain.
METHODS: We carried out a prospective cohort study including 63 consecutive women aged 17-52 years, scheduled for
laparoscopy due to chronic pelvic pain. Peripheral blood samples were withdrawn immediately before laparoscopy and
assayed for plasma concentrations of BDNF and Ucn1 using specific enzyme immunoassays.
RESULTS: Women ultimately proven to have endometriosis (n=31) had higher preoperative plasma BDNF (median =
710 [IQR 550-1100 pg/ml) vs. 575 [353-710 pg/ml, p<0.05, Mann-Whitney test) and Ucn1 levels (61 [49-104] vs. 53 [3169] pg/ml, p<0.05) compared to women who did not have endometriosis (n=32). The two markers were uncorrelated
(Spearman?s rho = 0.08), but BDNF levels were positively correlated with the intensity of pelvic pain (rho = 0.35,
p<0.01). The areas under the receiving operator characteristic (ROC) curves to detect endometriosis in this setting were,
respectively, 0.64 and 0.62 for BDNF and Ucn1, and the detection rates were 26% with BDNF and 24% with Ucn1 at
90% specificity cut-offs.
CONCLUSION: Both BDNF and Ucn1 are increased in women with pelvic pain and endometriosis compared to women
with pelvic pain of other etiologies. However, the low detection rate at the desired specificity suggests that these
neuropeptides do not qualify as useful diagnostic markers of endometriosis in women with painful symptoms.
------------------------------------Mots clefs : BDNF, Urocortin, pelvic pain, endometriosis, diagnostic marker
Auteurs :
Références : , , ,
Auteurs
Fernando M. Reis 1, Ana Luiza Rocha 2, Laura M. Maia 1, Erica L. Vieira 3, Antonio L. Teixeira 4,
1. Human Reproduction, UFMG, Belo Horizonte, BRAZIL
2. Obstetrics & Gynecology, UFMG, Belo Horizonte, BRAZIL
3. Laboratory of Medical Investigation, UFMG, Belo Horizonte, BRAZIL
4. Internal Medicine, UFMG, Belo Horizonte, BRAZIL
Auteurs (raw format)
Reis Fernando M. - email : [email protected] Etablissement : UFMG Service : Human Reproduction Ville : Belo
Horizonte Pays : BRAZIL Présentateur : Oui
Rocha Ana Luiza - email : [email protected] Etablissement : UFMG Service : Obstetrics & Gynecology Ville :
Belo Horizonte Pays : BRAZIL Présentateur : Non
Maia Laura M. - email : [email protected] Etablissement : UFMG Service : Human Reproduction Ville : Belo
Horizonte Pays : BRAZIL Présentateur : Non
Vieira Erica L. - email : [email protected] Etablissement : UFMG Service : Laboratory of Medical Investigation
Ville : Belo Horizonte Pays : BRAZIL Présentateur : Non
Teixeira Antonio L. - email : [email protected] Etablissement : UFMG Service : Internal Medicine Ville : Belo Horizonte
Pays : BRAZIL Présentateur : Non