Conférence Paul Sabatier
Transcription
Conférence Paul Sabatier
Conférence Paul Sabatier Pr Ruben Martin Institute of Chemical Research of Catalonia (ICIQ) Ni-catalyzed C-O Bond-Cleavage and Reductive Carboxylation Techniques Vendredi 30 octobre 2015 à 11h00 Auditorium Fernand Gallais Campus CNRS 205 205, route de Narbonne, Toulouse Contact LCC: Dr Eric Manoury, [email protected] Retrouvez le programme complet des séminaires sur le site web du LCC : http://www.lcc-toulouse.fr/ Ni-catalyzed C-O Bond-Cleavage and Reductive Carboxylation Techniques Ruben Martin* ([email protected]) Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007, Tarragona, Spain Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys, 23, 08010, Barcelona, Spain Activation of inert entities has been and continues to be of extreme interest to any organic chemist.1 This is especially true with activation of atmospheric molecules such as CO22 or the activation of relatively inert C- O bonds.3 Certainly, the development of operationally-simple and practical catalytic methods for the activation of the abovementioned entities would be highly desirable, as many of the current methods involve the use of stoichiometric amounts or air-sensitive organometallic reagents. In the last years, our research group has reported some progress directed towards the catalytic activation of inert molecular bonds, particularly on the field of C-O bond-functionalization and CO2 fixation (Scheme 1).4 These methods are characterized by their simplicity, wide substrate scope, including challenging substrate combinations with particularly sensitive functional groups and a diverse set of substitution patterns. Scheme 1. Metal-catalyzed functionalization of C-O bonds and CO2 at Martin´s laboratories (1) Activation of Unreactive Bonds in Organic Synthesis, Springer, Berlin 1999 (2) For reviews: (a) Tsuji, Y.; Fujihara, T. Chem. Commun. 2012, 48, 9956. (b) Cokoja, M.; Bruckmeier, C.; Rieger, B.; Herrmann, W. A.; Kühn, F. E. Angew. Chem. Int. Ed. 2011, 50, 8510. (3) For reviews: (a) Rosen, B. M.; Quasdorf, K. W.; Wilson, D. A.; Zhang, N.; Resmerita, A. –M.; Garg, N. K.; Percec, V. Chem. Rev. 2011, 111, 1346. (b) Cornella, J.; Zarate, C.; Martin, R. Chem. Soc. Rev. 2014, 43, 8081. (4) Recent examples from our group: (a) Leon, T.; Correa. A.; Martin, R. J. Am. Chem. Soc. 2013, 135, 1221. (b) Cornellà, J.; Gómez-Bengoa, E.; Martín, R. J. Am. Chem. Soc. 2013, 135, 1997. (c) Correa. A.; Leon, T.; Martin, R. J. Am. Chem. Soc. 2014, 136, 1062. (d) Zarate, C.; Martin, R. J. Am. Chem. Soc. 2014, 136, 2236. (e) Liu, Y.; Cornella, J.; Martin, R. J. Am. Chem. Soc. 2014, 136, 11212. (f) Moragas, T.; Cornella, J.; Martin, R. J. Am. Chem. Soc. 2014, 136, 17702. (g) Zarate, C.; Manzano, R.; Martin, R. J. Am. Chem. Soc. 2015, 137, 6754.