Awards, acknowledgments and honours for the students
Transcription
Awards, acknowledgments and honours for the students
ANNUAL REPORT 2014-2015 Instruct discover innovate remedy Hope is at our front door TABLE OF CONTENTS MESSAGE FROM THE CHAIRMAN OF THE BOARD AND FROM THE DIRECTOR-GENERAL OF THE CHU DE QUÉBEC..................................................................................................................................................... 4 MESSAGE FROM THE ACTING VICE-PRESIDENT (RESEARCH AND CREATION) AT UNIVERSITÉ LAVAL ............ 5 MESSAGE FROM THE DIRECTOR OF THE CHU DE QUÉBEC RESEARCH CENTRE ............................................. 6 OUR VISION, OUR MISSION, OUR VALUES AND OUR OBJECTIVES ............................................................... 8 ORGANIZATION CHART.............................................................................................................................. 9 STRUCTURE ............................................................................................................................................. 10 Board of Directors of the Research Centre ............................................................................................... 12 Management Committee......................................................................................................................... 12 RESEARCH ACTIVITY INDICES ................................................................................................................... 13 ENDOCRINOLOGY AND NEPHROLOGY AXIS .............................................................................................. 14 Awards, acknowledgments and honours for the researchers.................................................................... 14 Awards, acknowledgments and honours for the students ........................................................................ 16 INFECTIOUS AND IMMUNE DISEASES AXIS ............................................................................................... 17 Awards, acknowledgments and honours for the researchers.................................................................... 17 Awards, acknowledgments and honours for the students ........................................................................ 18 REGENERATIVE MEDICINE AXIS................................................................................................................ 19 Awards, acknowledgments and honours for the researchers.................................................................... 19 Awards, acknowledgments and honours for the students ........................................................................ 21 NEUROSCIENCES AXIS.............................................................................................................................. 22 Awards, acknowledgments and honours for the researchers.................................................................... 22 Awards, acknowledgments and honours for the students ........................................................................ 23 ONCOLOGY AXIS...................................................................................................................................... 24 Awards, acknowledgments and honours for the researchers.................................................................... 24 Awards, acknowledgments and honours for the students ........................................................................ 26 REPRODUCTION, MATERNAL AND CHILD HEALTH AXIS ............................................................................ 27 Awards, acknowledgments and distinctions for the researchers............................................................... 27 Awards, acknowledgments and distinctions for the students ................................................................... 28 POPULATION HEALTH AND OPTIMAL HEALTH CARE PRACTICES AXIS........................................................ 28 Awards, acknowledgments and distinctions for the researchers............................................................... 28 Awards, acknowledgments and distinctions for the students ................................................................... 31 THE RESEARCHERS ................................................................................................................................... 32 Endocrinology and Nephrology Axis......................................................................................................... 32 Infectious and Immune Diseases Axis ...................................................................................................... 33 Regenerative Medicine Axis..................................................................................................................... 34 Neurosciences Axis .................................................................................................................................. 35 Oncology Axis.......................................................................................................................................... 36 Reproduction, Maternal and Child Health Axis ......................................................................................... 37 Population Health and Optimal Health Care Practices Axis ....................................................................... 38 Clinical Researchers – Extradepartmental Research ................................................................................. 39 LIST OF ABBREVIATIONS, INITIALS AND ACRONYMS USED IN THIS DOCUMENT ........................................ 41 PUBLICATIONS ........................................................................................................................................ 42 Endocrinology and Nephrology Axis......................................................................................................... 42 Infectious and Immune Diseases Axis ...................................................................................................... 57 Regenerative Medicine Axis..................................................................................................................... 68 Neurosciences Axis .................................................................................................................................. 73 Oncology Axis.......................................................................................................................................... 80 Reproduction, Maternal and Child Health Axis ......................................................................................... 89 Population Health and Optimal Health Care Practices Axis ....................................................................... 94 Clinical Researchers (Extradepartmental Research) .................................................................................113 CONTACT INFORMATION ........................................................................................................................121 ACKNOWLEDGMENTS TO OUR PARTNERS ..............................................................................................122 The present Annual Report summarizes the period from April 1, 2014 to March 31, 2015 Message from the Chairman of the Board and from the Director-General of the CHU de Québec Madam, Sir, The year 2014-2015 has once again been a very active one and was marked by a major reform of the health care system. Although this restructuring endeavour has affected all aspects of our organization, the latter has demonstrated its ability to undertake such a metamorphosis while staying the course on the essentials, as it has shown many times in the past, while appealing to our collective memory of what a vital role its mission plays for the population. Despite this context of far-reaching structural mutations and financial stakes, which will continue for the next few years to come, the various teams of the Research Centre have managed to preserve their scientific rigour, stand firm on their research vision and press ahead with their pursuit of innovativeness and excellence. It is with the outmost pleasure that we are herein providing an overview of the outcomes of their determination and constant labor. Their most valuable support is absolutely vital for the energy that sustains our great organization and represents one of the mainstays of its renown as an academic center of excellence. We are indebted to our research teams and we are thanking them for their commitment and their contribution into achieving our mission in order to provide our patients with the best chances of recovery. Gaston Bédard Chairman of the Board Gertrude Bourdon Director-General www.chudequebec.ca 4 Vice-rectorat à la recherche et à la création Bureau de la vice-rectrice Message from the acting Vice-President (Research and Creation) at Université Laval Madam, Sir, The research environment has undergone major transformations over the last few years. The increased number of scientific challenges and the multiple societal and economic stakes that are currently facing us have required the implementation of novel strategies and are constantly daring us to find new opportunities for transformation, growth and improvement. The future of research is based on creativity, innovation and the implementation of new connections and the sharing of resources. This constitutes the vision that has prompted Université Laval to present its Strategic Plan for the Development of Research 2015-2020 (Plan stratégique de développement de la recherche 2015-2020), which is tied to our action plan Horizon 2017 and which includes, among its major objectives, the efficient development of research and the creation, the increased internationalization of training and research, as well as the implementation of global cooperation projects. I am convinced that our researchers’ passion and creativity as well as their ability to take up challenges will contribute to their fulfillment. In the name of Université Laval, I salute the sheer magnitude of the work accomplished by the research teams, and the high standard of their realizations, and I pledge them my fullest support towards the pursuit of their ideals of excellence and discovery as well as their quest for achievement. I also want to express my most sincere thanks for their dedication to Université Laval’s prestige in the Quebec City area as much as outside our frontiers. Edwin Bourget Vice-President (Research and Creation) at Université Laval Pavillon des Sciences de l’éducation 418 656-2599 2320, rue des Bibliothèques Télécopieur : 418 656-2401 Québec (Québec) G1V 0A6 www.vrr.ulaval.ca CANADA 5 Message from the Director of the CHU de Québec Research Centre Madam, Sir, With the presentation of Bill Project 10 (Bill 1) by the Minister of Health and Social Services, the year 2014-2015 has been marked by profound transformations and a complete reorganization of the health care system and institutions in Quebec. This unexpected context of major changes has shown us that despite unforeseen circumstances, we are able to focus our energy on our top priorities by relying on our potential and our willingness to transform this situation into a positive force that allows us to reinvent ourselves and shape our future. With research revenues of 85,7 million dollars, the CHU de Québec Research Centre is still holding its position as the most important francophone research centre in North America. Canada’s Top 40 Research Hospitals 2014 ranks it as the second largest research centre in Quebec, next to McGill University Health Centre (170 M $) and before the CHUM Research Centre (66 M $). At the Canadian level, analysts rank our Centre as the tenth largest. Research revenues include funds that support research in the form of grants, collaborations or contracts. This year has also been fruitful by its innovation with several research achievements, including marked advances in many fields such as tissue engineering and stem cell production, medical imaging, neurodegenerative diseases and prostate cancer. In the wake of the latter events, the Research Center Board of Directors as well as the researchers had the opportunity to participate actively to the new hospital complex project at the Hôpital de l’Enfant-Jésus in order to position the new research centre advantageously. With the help of Kaizen workshops among other strategies, this consulting process has allowed to highlight the specific needs of research in the various fields that will be regrouped within this new institute. This was also an opportunity for us to rule in favor of the first step of the project, namely the creation of the future Cancerology Research Centre, in order to identify the needs regarding clinical activities and research infrastructures. The future premises will be available within the next few years. The creation of a Neurosciences Center has also been scheduled. The clinical blueprint of the new hospital complex has been submitted and approved by the Ministry of Health and Social Services (MHSS), which has allowed us to move forward with the preparation of the Bridge Funding Opportunity (BFO). This large-scale project is a forward-looking endeavor through its ability to offer improved services to the whole region of Eastern Quebec. It will also enable the investigators to establish closer connections with various medical specialties as well as health and research activities. We have also had the opportunity to contribute to Université Laval’s Strategic Development Plan which was requested by the Government of Quebec, as well as to the implementation of Alliance Santé Québec, a network that regroups leaders in research and innovation in health and social services in the metropolitan area of Quebec City and whose strategy relies on the concept of sustainable health. Its mission consists in maximizing the positive outcomes of scientific research regarding the improvement of health and well-being among the population, the health care and social services ecosystem, as well as the regional economy. 6 The Research Centre has also been involved in the vast Financing Campaign of the Fondation du CHU de Québec, which generated more than 20 million dollars for research from Quebec City Hall, banks, companies and foundations. Moreover, a new initiative on the part of the Fondation du CHU de Québec and of the Research Centre has allowed to accumulate a sum of nearly 250 000$, which was distributed in the form of scholarships for the benefit of graduate students who are working within our organization. The implementation of the Research Centre’s Strategic Development Blueprint (Plan de développement stratégique du Centre de recherche) keeps unfolding as seen with the consolidation of the different axes and campuses as well as the harmonization of practices and shared facilities. The Centre is now fully harmonized regarding the budgets, which are distributed according to the priorization criteria and performance indices on which we had agreed. The Board of Directors of the Research Centre welcomed three new members, namely Dr. Stéphane Bolduc as Head of the Regenerative Medicine Axis, and Dr. Martin Simard as Head of the Oncology Axis. Finally, Yves Fradet was appointed Acting Assistant Director of Clinical Research. Nine new investigators were recruited despite the current difficult financial context, and the number of outstanding candidate applications confirms the attractiveness of the CHU de Québec Research Centre. The Second Journée de la recherche (Research Day) to which were invited not only the students and researchers, but also all personnel involved in research and management, was held at the Quebec City Convention Centre on October 20, 2014. We were pleased to welcome two prestigious speakers, namely Professor Marc G. Caron from the Department of Cell Biology at Duke University, and Professor Marc R. Montminy from the Salk Institute, who are both members of our international Scientific Advisory Committee. Two FRQS Awards for Excellence and fourteen research scholarships were bestowed on the students. The implementation of the Clinical Research Unit will be pursued next year, which will allow to unify all investigators involved in clinical and evaluative research as well as a better sharing of information, methods and work tools. This unit will also permit to maintain a research quality of the highest standards and to position our institution as a major actor in the field of clinical research. This enhancement process will also allow to increase the number of available cutting-edge treatments, to improve patient care through the generation, updating and translation of top-level knowledge, thereby increasing the likelihood of improvements of the health and recovery of the patients. I must emphasize the remarkable work accomplished by our investigators, students and all research and support teams once again during this past year, as well as their constant effort towards the positioning of our research centre among the very best. I want to congratulate them and to express my gratitude for their dedication and to encourage them to pursue their goals within our research environment where they can find so much inspiration, innovation and a sheer abundance of discoveries. I also want to thank all our partners, and especially the Fondation du CHU de Québec, which keeps surpassing itself relentlessly in order to support our organization and to allow the longterm financing of research projects that will benefit the patients in the long run. Serge Rivest, Ph. D. Director of the Research Centre 7 Our vision, our mission, our values and our objectives Our Vision An integrated approach to cutting-edge technologies that can lead to the discovery, development and optimization of innovations in personalized health care. Our Misson • To insure the training of future investigators in basic, clinical, and population health research. • To stimulate innovation by developing new technologies applicable to the health care system. • To accelerate the progress of knowledge in order to translate it into concrete applications aimed at promoting health, improvement of health care and quality of life. • To harmonize excellence in basic, clinical and population health research with the other missions of the CHU de Québec. Our values • Scientific rigour and integrity • The achievement of excellence • The sharing of knowledge • Respect Our objectives • To set up an environment conducive to a successful consolidation • To increase the performance and scientific prestige of the research teams • To promote an environment conducive to innovation • To favour the transfer of knowledge towards direct applications aimed at improving health care • To develop new approaches to health research funding. 8 Organization Chart 9 STRUCTURE Themes (axes) and divisions : Endocrinology and Nephrology 1. 2. 3. 4. Molecular medicine of hormono-sensitive conditions Mechanisms of action of steroidal hormones Endocrine and metabolic diseases Vascular and renal diseases Infectious and Immune Diseases 1. Microbial pathogenesis and host response 2. Parasitic diseases 3. Mechanisms of antimicrobial resistance and development of point-of-care diagnostic tools for personalized medicine 4. Impact of vaccines on populations 5. Mechanisms of inflammation 6. Systemic autoimmune rheumatic diseases and bone diseases Regenerative Medicine 1. Biomaterials, prosthetics and implants 2. Tissue engineering and stem cells 3. Vision health Neurosciences 1. Neurodegenerative and neuro-oncological diseases 2. Neurovascular and traumatic injuries affecting the brain, spinal cord and peripheral nerves 3. Neurobiology of homeostasis and behaviours 4. Neuromuscular system disorders Oncology 1. 2. 3. 4. 5. Cellular and molecular mechanisms of cancer Urological and gynaecological cancers Breast cancer – Prevention, screening, care and quality of life Radio-oncology, physics and medical imaging Psychosocial oncology and palliative care 10 Reproduction and Mother & Child Health 1. Reproduction and infertility 2. Pregnancy and fœtal development 3. Newborn and infant health Population Health and Optimal Health Care Practices 1. 2. 3. 4. Global and environmental health Aging Traumatology − emergency − intensive care Knowledge transfer and evaluation of technologies and health intervention methods (KT-ETHIM [French: TC-ETMIS]) 6. Optimal use of treatments Cross structure Six platforms 1. 2. 3. 4. 5. 6. Clinical, Population and Evaluative research Genomics Centre Animal Models Imaging and Cytometry Analytical and Medicinal Chemistry Multidisciplinary Center of Tissue Engineering 11 Board of Directors of the Research Centre Ms. Gertrude Bourdon Director-General of the CHU de Québec Dr. Jean-Claude Forest Deputy Director-General of Medical and Academic Affairs Dr. Serge Rivest Director of the Research Centre Dr. Yves Fradet Acting Assistant Director of Clinical Research Dr. Jacques Simard Assistant Director of Basic Research Dr. Charles Roberge Deputy Director of Administration Dr. Lucie Germain Vice-Dean of Research and Graduate Studies, Faculty of Medicine, Université Laval Dr. Pierre Julien Director –Endocrinology and Nephrology Axis Dr. Barbara Papadopoulou Director –Infectious and Immune Diseases Axis Dr. Stéphane Bolduc Director –Regenerative Medicine Axis Dr. Guy Drolet Director –Neurosciences Axis Dr. Martin Simard Director –Oncology Axis Dr. Robert Sullivan Director –Reproductive, Maternal and Child Health Axis Dr. Michel Alary Director –Population Health and Optimal Health Care Practices Axis Management Committee M. Christian Brouillette, Administrative Coordinator (CHUL campus) M. Luc Crépault, Financial Management Officer (HSS and HEJ campuses), Administrator –Regenerative Medicine Axis Mme Floriana De Almeida, Administrator –Population Health and Optimal Health Care Practices Axis M. Yvan Desrochers, Coordinator of Research Financial Management Mme Caroline Dubé, Head of Animal Housing Services Mme Diane Hamel, Administrative Coordinator (HDQ campus) and Administrator –Oncology Axis Mme Crina Lador, Administrator–Neurosciences Axis and Reproductive, Maternal and Child Health Axis Dr. Nathalie Laflamme, Coordinator of the Clinical Research Platform M. Jean Lagueux, Administrative Coordinator (HSFA campus) Mme Brigitte Lambert, Administrator–Infectious and immune Diseases Axis Mme Diane Martin, Executive Officer (CHUL) Mme Chantal Pelchat, Administrator–Endocrinology and Nephrology Axis Dr. Charles Roberge, Deputy Director of Administration of the Research Centre 12 Research Activity Indices INVESTIGATORS Regulars and associates Affiliated SUBTOTAL – RESEARCHERS 2012-2013 2013-2014 2014-2015 319 210 529 329 208 537 317 192 509 149 498 339 986 137 461 322 920 112 437 322 871 800 1 298 1 247 2 315 2 741 2 627 894 98 1 531 2 523 1 140 80 1 750 2 970 995 39 939 1 973 2 232 405 $1 22 678 425 $2 5 806 899 $ 22 142 711 $3 52 860 440 $ 2 715 874 $ 25 144 408 $ 5 937 392 $ 18 078 606 $ 51 876 280 $ 2 757 562 $ 25 559 597 $ 6 887 469 $ 20 220 872 $ 55 425 500 $ 3 014 244 $1 1 810 513 $2 6 408 383 $3 11 233 140 $ 8 359 792 $ 5 467 493 $ 3 814 452 $ 81 735 317 $ 3 332 296 $ 1 907 993 $ 5 904 663 $ 11 144 952 $ 9 360 644 $ 5 726 226 $ 3 717 979 $ 81 826 081 $ 3 394 723 $ 1 604 156 $ 5 698 736 $ 10 697 615 $ 10 002 529 $ 5 756 622 $ 3 819 068 $ 85 701 334 $ POST-GRADUATE STUDENTS & TRAINEES Postdoctoral trainees and fellows Ph.D. Master’s SUBTOTAL –STUDENTS EMPLOYEES Administrative personnel, technicians, research nurses, etc. GRAND TOTAL – RESEARCH-ASSOCIATED PERSONNEL PUBLICATIONS AND COMMUNICATION PAPERS Journal Articles Books and book chapters Meeting papers (posters & talks) GRAND TOTAL – PUBLICATIONS AND PAPERS FINANCING GRANTS Fonds de recherche du Québec (FRQ) Federal agencies (HSRC, NSERC, CIHR) CFI (including shares from MSSS & partners) Others SUBTOTAL - GRANTS SCHOLARSHIPS Fonds de recherche du Québec (FRQ) Federal agencies (HSRC, NSERC, CIHR) Others SUBTOTAL - SCHOLARSHIPS Partnerships, sponsorships and contracts Operating budget (FRQS) Federal indirect costs GRAND TOTAL – FINANCING 1 2 3 Does not include sums received from the FRQS in 2012-2013. Including only sums received from the CIHR in 2012-2013. Represents all sums received except those from the FRQS and CIHR (as well as CFI for grants) in 2012-2013. 13 Endocrinology and Nephrology Axis Awards, acknowledgments and honours for the researchers In collaboration with the group of Dr. Piotr Milkiewicz’s, director of the Department of Hepatology of Warsaw’s Hospital (Poland), Dr. Olivier Barbier’s laboratory has evidenced the potential role of fibroblast growth factor-19 for the evaluation of the severity of chronic hepatic diseases (Scientific Reports). The same group of investigators also identified a microRNA (miR378a05p) as a major regulator of the hepatic detoxification of biliary acids, and showed that this control mechanism was dysregulated in the liver of patients with primary sclerosing cholangitis, an autoimmune hepatobiliary disorder (Journal of Immunology Research). Drs. Eric Biron and Jacques Corbeil have obtained a 900 000 $ grant from the Consortium québécois sur la découverte du médicament (CQDM) for their project, Computational and machine learning approaches to improve design and screening of high bioactivity peptides for drug discovery. Major grants have been awarded by the Dairy Farmers of Canada to Dr. Patrick Couture (1.4 million $), in collaboration with Dr. Benoît Lamarche for the implementation of the Institute of Nutrition and Functional Foods (INFF), a research program that is integrated with the theme of milk and cardiovascular health. Dr. Chantal Guillemette and her collaborators at the National Cancer Institute (NCI/NIH) published two papers with a high impact factor: one describes the metabolic profile of circulating steroids in men with breast cancer and was published in the Journal of Clinical Oncology. The second one, A case-control analysis of circulating sex steroid hormones in relation to Barrett’s esophagus, addresses the role of steroidal hormones in Barrett’s syndrome, a complication of chronic gastro-oesophageal reflux, which can change into an oesophageal adenocarcinoma (American Journal of Gastroenterology). Dr. Guillemette also published a review article on the heterogeneity of glucuronidation pathways and its pharmacological and toxicological implications in drug metabolism, Pharmacogenomics of Human Uridine Diphospho-glucuronosyltransferase and clinical implications (Clinical Pharmacology and Therapeutics). A grant of 788 000 $ from the Canadian Institutes of Health Research (CIHR) was obtained by Drs. Chantal Guillemette and Arnaud Droit for the study of human UDP-glucuronosyltransferase pharmacogenomics. Dr. Pierre Julien’s research program, in collaboration with Dr. Jean-François Bilodeau, focused on the identification of lipid biomarkers (isoprostanes) resulting from the oxidation of fatty acids. These studies on the response to oxidative stress during pregnancy led to the identification of early markers for preeclampsia and were published in Prostaglandins, Leukotrienes and Essential Fatty Acids, as well as to a patent (PCT/CA2013/000490). Furthermore, in collaboration with Dr. Isabelle Marc, a clinical research grant of 2.1 million $ from the CIHR to study maternal supplementation with omega-3 fatty acids to study bronchopulmonary dysplasia in very preterm newborns in a controlled randomized assay known as MOBYDIck. Dr. Michel Lebel’s team, in collaboration with investigators from McGill University, discovered a 12gene signature endowed with the ability to predict whether patients with colorectal cancer might respond to 5-fluorouracil or benefit from a chemotherapeutic treatment with the FOLFIRI drug 14 combination. That study was carried out as part of the Quebec-Clinical Research Organization in Cancer (Q-CROC) and led to a patent (Eric R. Paquet and Michel Lebel). This research project also resulted in the paper A 12-gene signature associated with benefit from 5-Fluorouracil and FOLFIRI in early-stage colon cancer, which was published in The Journal of Pathology: Clinical Research. A 334 000$ grant from the Canadian Foundation for Innovation (CFI) to Dr. Éric Lévesque has allowed to acquire a complex set of specialized apparatus, including a digital OCR system and a real-time flow cytometry system. Moreover, a 400 000$ grant from the CFI to Dr. Chantal Guillemette has enabled the acquisition of a new liquid chromatography/mass spectrometry system (AB Sciex 6500) for the analysis of small molecules in biological matrices. Drs. Lévesque and Guillemette conducted a project that showed the potential of novel prognostic markers for prostate cancer to predict an increased risk for progression of the disease. Results from this research project were published in Clinical Cancer Research. Thus, through the identification of these new markers involved in estrogen metabolism, they established that estrogen metabolism might play an important role in prostate carcinogenesis and could lead to improvements in our ability to predict relapses. This work was conducted in collaboration with the urologists Drs. Louis Lacombe and Yves Fradet from the Oncology Axis. Dr. Fabrice Mac-Way ranked first at the provincial competition for a Clinician Researcher scholarship from the Fonds de recherche du Québec-Santé (FRQS). His studies address the physiopathological mechanisms of renal osteodystrophy. AmorChem, Université Laval and the CHU de Québec Research Centre have announced in April, 2014, that they will collaborate towards the development of new drugs for the treatment of endometriosis and estrogen-sensitive cancers. The goal of this collaborative effort is the preclinical development of an inhibitor of an enzyme, 17β-HSD1, which is responsible of a major step in estradiol biosynthesis. This inhibitor was discovered and characterized by Dr. Donald Poirier and his team. The molecule thus developed could potentially be medically relevant since current treatments for breast cancer are not curative and do not relieve chronic pain associated with this malignancy, which affects 10 to 15% of women of childbearing age and which represents one of the major causes of infertility. That molecule might not only attenuate pain that is associated with the disease, but also be used for the treatment of breast and endometrial cancer, which are both sensitive to estrogens. A new study by Dr. Iwona Rudkowska demonstrates the benefits of dairy products on metabolic health. Although dairy products are well known for their high contents in minerals that play positive roles, in bone growth and homeostasis, recent studies have shown that daily consumption of these foods could also have beneficial effects on metabolic health and decrease risks for diseases of metabolic origin such as obesity and type-2 diabetes. Dr. Rudkowska’s article, Associations between dairy intake and metabolic risk parameters in a healthy French-Canadian population, was published in Applied Physiology, Nutrition and Metabolism. The most significant publications by Dr. Jacques Simard have come from his work on the large-scale genotyping project iCOGS, which led to the identification of 15 new susceptibility loci for breast cancer and six new loci associated with an increased risk for ovarian cancer (Nature Genetics). Dr. Jacques Simard renewed his Canada Research Chair in oncogenetics to the amount of 1,4 million $ and is a partner within two large-scale interdisciplinary projects with the European Commission’s Horizon 2020 project. The first project, BRIDGES (Breast Cancer Risk after Diagnostic Gene Sequencing, 6 200 000 €), consists in the characterization of the impact of mutations in candidate breast cancer genes in order to determine how these variants influence the etiology of that disease. 15 The second project, B-CAST (Breast Cancer Stratification: Understanding the Determinants of Risk and Prognosis of Molecular Subtypes, 5 983 365 €), will seek to understand the biological mechanisms underlying the etiology of breast cancer heterogeneity, and their effect on the occurrence and clinical progression of the various subtypes of that cancer. Dr. Jonny St-Amand has obtained a 666 000 $ from the CIHR for the study of the role of the exerciseinducible gene SPARC against sarcopenia, a geriatric syndrome that is characterized by a loss of muscle mass. Awards, acknowledgments and honours for the students Eric Allain, PhD student, has received a Leadership and Sustainable Development Scholarship from Université Laval, as well as a Recruitment Studentship for Academic Record and Research Excellence from the Faculty of Pharmacy, Université Laval. Yannick Audet-Delage received the Award for Best Oral Presentation at the Endocrinology & Nephrology Axis Day, in December 2014. He was also a finalist for the Hans-Selye Prize at the 56th Annual Meeting of the Club de Recherches Cliniques du Québec (CRCQ). Camille Bock-Girard, Master’s student, was awarded with a Studentship from the Fonds de l’enseignement et de la recherche de l’Université Laval (Université Laval’s Education and Research Fund). Frédérick Bouffard, Master’s student in Molecular Medicine, earned the distinction of being featured at the Roll of Honor of the Faculty of Graduate and Postdoctoral Studies for the excellence of his Master’s studies. Valérie Brousseau, Master’s candidate, was awarded a 15 000 $ annual studentship (2015-2017) by the FRQS in order to realize her research project, Glucuronidation and sulfatation of 24Shydroxycholesterol: Metabolism, inactivation and influences on LXR. Véronique Lafleur, PhD student, obtained the Didier-Mouginot Scholarship from of the CHU de Québec Foundation for her project Identification and characterization of a new mechanism regulating hypoxic signalization. Alan Tourancheau, PhD student, was awarded the Prize for Best Oral Presentation at the 2nd Scientific Day of the CHU de Québec Research Center for his presentation Unravelling the transcriptomic landscape of the major phase II drug metabolizing pathway using targeted RNA sequencing. His work was published in The Pharmacogenomics Journal. Three PhD candidates have received studentships from the Oncology, Molecular Endocrinology and Human Genomics Research Center (= Centre de recherche en endocrinologie moléculaire et oncologique et génomique humaine [CREMOGH]), namely Yannick Audet-Delage (Modulation of cell metabolism by splicing variants of the human UGT1A gene)l Cyril Bigo (Omega-3 fatty acids and oxidative stress in the vascular wall) and Marine DaSilva (Determination of the mechanisms of action of dairy product nutrients on the gene expression and metabolic parameters in type-II diabetes). The CREMOGH has also attributed studentships to Master’s students: Steffany Grondin (Identification and validation of rare variations/ mutations in new breast cancer susceptibility genes) and Sofia Laforest (Obesity and breast cancer: Importance of mammary adipose tissue dysfunction). 16 Infectious and Immune Diseases Axis Awards, acknowledgments and honours for the researchers A tribute was paid to Michel G. Bergeron’s team at the ceremony « Célébrons le Partenariat 2015 » (Let’s Celebrate Partnership 2015) which was organized by the Association pour le développement de la recherche et de l’innovation du Québec (ADRIQ) and the Natural Sciences and Engineering Council of Canada (NSERC). This honor aims at acknowledging the successes of technological collaborations in Quebec between investigators, entrepreneurs and their partners. In the spring of 2014, as part of the Fonds de partenariat pour un Québec innovant et en santé (FPQIS) competition, Dr. Michel G. Bergeron has obtained a 7,4 million $ from the Quebec Ministry of Finance and Economy to develop two tests for the rapid diagnosis of hospital-related infections or multiresistant bacterial infections. With the support of that Ministry, the latter partnership between Université Laval, the CHU de Québec and GenePOC Inc. will permit the development, industrialization and clinical evaluation of two rapid diagnostic tests. This large-scale transdisciplinary project brings together a consortium of experts from Laval, McGill and Montreal Universities, their teaching hospitals, the Institut national de santé publique du Québec, the Laboratoire de Santé publique du Québec and GenePOC. Concurrently with the technological, industrial and clinical aspects of this project, a psychosocial study is conducted by Dr. Ève Dubé in order to evaluate the perception of the health care system’s stakeholders towards the applicability of rapid molecular diagnostic tools in the hospital environment (in the laboratory and at the point of service) as well as their establishment within the Quebec’s health care system. Upon the introduction of the vaccine against human papilloma virus (HPV), the manufacturer was recommending to administer three doses in order to insure maximal protection. Since then, data from various sources suggest that two doses could provide sufficient immunity when the vaccine is administered to girls younger than 15. One of the major sources of such data is the Quebec study, by investigators Vladimir Gilca, Chantal Sauvageau, Nicole Boulianne, Gaston De Serres and Marc Dionne, which demonstrated that after a single dose, virtually all girls vaccinated with the quadrivalent vaccine at 9-10 years of age already had detectable antibodies, that the second dose elicited a memory-type response, and that the third dose, which was administered three years and a half following the first one, only weakly increased antibody levels compared to those observed after the second dose. Moreover, Drs. Marc Brisson and Jean-François Laprise from the Population Health and Optimal Health Care Practices Axis, as well as Drs. Mark Jit and Yoon Hong Choi from Public Health England, have studied the issue and, in a recent issue of the British Medical Journal, concluded that if protection has a duration ≥ 20 years, the addition of a third dose does not bring any clear advantage since protection afforded by two doses would span the life period during which women are the most sexually active. Therefore, dispensing from the third dose would not impact women’s health and would translate into a substantial cost reduction. These two studies have contributed to the World’s Health Organization’ s position which is to recommend a two-dose schedule for young from 9 to 13 years old and have already had an incidence on vaccination programs in many countries and provinces, which have abandoned the third dose for women younger than 15 years of age. Dr. Sylvain Moineau and his team of postdoctoral trainees have made the surprising finding that, like humans, bacteria also possess a defense mechanism (CRISPR-Cas) that provides them with a defense 17 mechanism against viral attacks. Bacteria use a principle that is similar to human vaccination, which consists in exposing bacteria to attenuated viruses in order to confer a defense mechanism against the latter. That discovery, which was published in Nature Communications, has been the topic of an article, The Top 10 Major Breakthroughs of 2014 in the daily newspaper Le Soleil. Dr. Moineau is also included in the 2014 list of the World's Most Influential Scientific Minds by Thomson Reuters, the wellknown strategic information society. This selection implies that between 2002 and 2012, his work was the most frequently cited by researchers in the same field. Dr. Moineau also received the SummaRecherche Award from Université Laval’s Faculty of Sciences and Engineering. In 2015, Dr. Marc Ouellette, Scientific Director of the CIHR’s Institute of Infectious and Immune Diseases (IIMD), received the Public Service Award of Excellence Award from the Governor General of Canada for a team’s work on the management of the Ebola virus crisis. Dr. Barbara Papadopoulou was appointed Vice-President of the FRQS Board of Directors. Dr. Marc Pouliot was appointed academic delegate to the CIHR in September 2014, to replace Dr. Lucie Germain, A discovery made by Drs. Patrick Provost and Éric Boilard has been selected among the Top 10 Major Breakthroughs of 2014 according to the daily newspaper Le Soleil. Their work has allowed to understand the cause of the inflammatory reactions that are triggered by blood platelet transfusions in 2% of cases despite the sterilization techniques currently used. Until recently, the scientific community was under the belief that the latter immune response was caused by bacteria or viruses that had survived the sterilization treatments. However, according to these investigators, that immune response would rather be due to mitochondria – microscopic intracellular structures that act as the energy plants of the cell, literally – released by platelets themselves and which share several common features with bacteria. Many countries have just enforced the mandatory treatment of platelets with antibacterials, although the latter measure might well be pointless or even detrimental, since the study also demonstrated that some of these anti-pathogenic treatments not only kill microbes, but also damage platelets themselves. Furthermore, studies have shown that upon transfusion of platelets having undergone prior pathogen-reducing treatment, a second dose is often required. In June 2014, Dr. Jean Sévigny has published an article in J. Med. Chem. In which he identified and synthesized the most potent NPP1 inhibitors known to date, and which might well serve as candidate drugs for the treatment of pseudogout (or articular chondrocalcinosis), as well as aortic valve calcification diseases. Dr. Michel J. Tremblay’s team has identified the molecular mechanisms that control the integration of ICAM-1, which is endowed with the ability to significantly increase the infectious potential of HIV (Journal of Virology). This work brings new avenues for the development of antiviral agents that would be less susceptible to the problem of resistance. Awards, acknowledgments and honours for the students Alexander Hynes, postdoctoral trainee with Dr. Sylvain Moineau, was Laureate of the Fonds de recherche du Québec Nature et Technologies (FRQNT) in October 2014. 18 Regenerative Medicine Axis Awards, acknowledgments and honours for the researchers Drs. François A. Auger, Véronique Moulin and Lucie Germain, of the LOEX, have received the endorsement of Health Canada to undertake a Phase-1 to -2 clinical trial for autologous bilamellar skin grafts on severe burn patient. This study is currently in its recruiting phase. Thanks to a 300 000 $ grant that was obtained through a partnership involving the FRQS, the Marigold Foundation, and Brain Canada, researchers from the CHU de Québec, among whom are Drs. François Berthod, François Gros-Louis and Solange Landreville, have been the first in Quebec to propose a service for the production of induced pluripotent stem cells from small skin, muscle or blood cell fragments. This infrastructure is under the direction of Dr. Jack Puymirat in co-direction with Dr. François Gros-Louis. These cells have the capacity to reproduce any type of cells in the human body. The team led by Dr. Jack Puymirat, a neurologist and investigator, has developed an expertise that will enable the production of human stem cells, whose fields of application and advantages are numerous. Unlike cells obtained from a patient, pluripotent stem cells have an unlimited lifespan, which represents a larger amount of the “raw material” necessary to carry out the experiments that are planned for the objectives of research. The latter aspect is especially crucial in the study of neurodegenerative diseases such as Parkinson’s or Alzheimer’s diseases, as well as neuromuscular disorders, since the lack of biological material is severely limiting research and therapeutic development. The presence of this platform in the metro Quebec area will not only contribute to the understanding of certain diseases and ultimately, favor the development of new treatments, but it will also promote the development and transfer of knowledge as well as national and international collaborative efforts. A team from the Laboratoire d'organogénèse expérimentale (LOEX) consisting of Drs. Stéphane Bolduc, Francine Goulet and Sara Bouhout has refined the design of a bladder built by tissue engineering on which it had been working for several years by recreating in vitro the physiological conditions of a bladder that has developed in vivo. The model produced accordingly possesses a structure similar to that of human bladder. Since the decision was taken to add urine intermittently to the culture medium, results have been truly spectacular: cell proliferation is twice as fast during the first 24 hours when urine is applied to the basal layer. Dr. Bolduc surmises that the catalytic factors in play here are probably growth factors present in urine. Moreover, it must be pointed out that cells are permanently submerged in the growth medium: the air-liquid interface is important for skin or bronchi culture, which is not the case for bladder culture, since, in the body, urothelial cells are never exposed to the air. These culture procedures permit the production of a model bladder with welldifferentiated cells within 15 days. Its resistance is not sufficient yet to allow a tissue graft, but studies are still ongoing in that direction. This model could however be very useful for the study of some pathologies or to conduct toxicological and pharmacological tests on the human bladder. Dr. Marc-André Fortin, from the Laboratory for Biomaterials in Imaging, has developed a promising treatment for the brachytherapy of prostate cancer. This treatment based on radioactive gold nanoparticles, has allowed to delay by three months the growth of aggressive cancerous tumours upon their implantation in an animal model. These very promising results have been presented by Myriam Laprise-Pelletier and Mathieu Bouchard, graduate students, at the last World Congress on Medical Physics and Biomedical Engineering, which was held in Toronto in June 2015. This new approach leads the way to many perspectives towards the improvement of internal radiotherapy 19 treatments of prostate and breast cancer. In 2014, these studies had been the topic of two popularization press releases in Quebec (Le Devoir, May 13, 2014: “Golden-coated radioactive nanoparticles to better fight cancer” [Des nanoparticules radioactives couvertes d’or pour mieux traiter le cancer]; Le Journal de Montréal, May 12, 2014: “Anticancer gold nanoparticles” [Des nanoparticules d’or anticancer]). Dr. Fortin’s work was supported by an Innovation Grant from the Canadian Cancer Society. Dr. Marc-André Fortin’s work on the biodistribution of mesoporous silica nanoparticles for targeted drug delivery, which is supported by the NSERC-CIHR and the FRQNT, earned the honor of being featured on the front page of the Journal of Materials Chemistry B : Materials in Medicine. This scientific journal, which is published by the Royal Society of Chemistry, is one of the most prestigious in the field of chemistry of materials with medical applications. Dr. Fortin’s group has been the first to uncover how porous nanoparticles for drug delivery diffuse and distribute themselves throughout the human body, and are eliminated from the various organs. Using biomedical imaging (magnetic resonance and positron emission tomography), his group was also the very first to provide indications that nanoparticle fragments could be reinternalized by the blood circulation after their intestinal transit. This new basic knowledge could have a major impact on the design of drug delivery systems based on nanoparticle vectors. In the journal Tissue Engineering, Drs. Julie Fradette and Marc-André Fortin published their preclinical results showing the in vitro production of adipose tissue grafts reconstructed by tissue bioengineering, as well as their non-invasive and longitudinal monitoring using magnetic resonance imaging, following methods that are clinically applicable upon autologous grafts of fatty tissue that can be sampled, for example, during a mammary reconstruction. In April 2014, Dr. Lucie Germain was designated « Personality of the week » by the daily newspaper La Presse, and Dr. Richard Bazin was chosen as one of the Laureates of Le Soleil newspaper - RadioCanada. Both researchers were acknowledged for their visionary breakthroughs, which are a first in Canada: after several years of efforts on grafts of corneal tissue grown in vitro by Dr. Germain’s team, these results demonstrate that these corneas could help many persons to recover a better vision. The results obtained after the six first grafts are excellent. Cornea graft is performed starting from stem cells obtained from the patient, which eliminates the risk of rejection by the body. All in vitro corneal grafts have been realized by Dr. Richard Bazin, an ophthalmologist and corneologist, and his team of cornea specialists. If results to come stay conclusive, grafts of cultured corneas could be offered on a regular basis to patients with tumors, injuries, burns or congenital corneal disorders. In 2014, Université Laval and the CHU de Québec have announced the creation of the Research Chair in Stem Cells and Tissue Engineering, whose titular holder is Dr. Lucie Germain. Tissue engineering, which makes possible the in vitro construction of a wide variety of tissues and organs such as the skin, cornea, ligaments, blood vessels or heart valves, is an extremely promising avenue to palliate the shortages in tissues and organs for grafting, which are becoming increasingly important due to the strong demand for such biological materials, as well as the decrease in the number of donors in North America. This Chair’s mission will be to improve the methods of tissue and organ production in the laboratory and to promote their use in the actual practicing of grafts. The creation of that Chair was made possible thanks to the Fondation des pompiers du Québec pour les grands brûlés. Dr. Germain was also awarded a similarly named Canada Research Chair, senior level, which was granted for a seven-year period. 20 Dr. Lucie Germain was appointed Vice-Dean of Research and Post-Graduate Studies of the Faculty of Medicine of Université Laval for a 4-year term. Dr. Solange Landreville has obtained an individual grant of 320 000 $ from the CFI and the MSSS for the purchase of specialized equipment for oxygen-controlled cell culture. Several ocular pathologies affecting Canadians involve an oxygen deficit for their progression, such as with uveal melanoma (ocular cancer) and diabetic retinopathy (a complication of diabetes). Translation of results “from the bench” to the clinic narrowly depends on their physiological validity, and therefore, on the maintenance in cultured cells of biological functions and conditions that are as close as possible to those found in the tissues of origin. It is therefore of utmost importance to modulate the percentage of oxygen in order to improve cell culture and tissue engineering models used in ophthalmology. Dr. Diego Mantovani, holder of a Canada Research Chair on Biomaterials, and his collaborators, are working together with a Brazilian team to design bandages made from banana fibers, whose properties are antibacterial. A polymer derived from shrimp shells is also currently under investigation for coating pacemakers due to its antibacterial and wound healing properties Dr. Véronique Moulin and her team at the LOEX have noted an unexpected effect from chitosan, a derivative of chitin, a compound present in the exoskeleton of crustaceans and insects: chitosan prevents the adhesion and proliferation of cancer cells and is well tolerated by the body. Its utilization might therefore be considered in combination with other treatments to improve their efficacy. This study, which was published in the International Journal of Biological Macromolecules, was authored by Laure Gibot, Stéphane Chabaud, Sara Bouhout, Dr. Stéphane Bolduc, Dr. François A. Auger and Dr. Véronique Moulin. Awards, acknowledgments and honours for the students Sarah Bernier, a PhD candidate in Dr. Christian Salesse’s team in the field of visual health, finished first at the latest CIHR PhD Studentships competition, for her project Structure and membrane binding of R9AP and its role in bradyopsia. Camille Couture received a Bourse de performance (Performance Studentship) from the FRQS - Vision Health Research Network, as well as a NSERC Undergraduate Student Research Award. The graduate students within the theme Santé de la vision (Vision Health) performed quite well at the last FRQS Studentship competition: Jade Pomerleau and Laurence Trudel-Vandal, both Master’s students in Dr. Solange Landreville’s team, have received Master’s studentships in April 2014. Under the Dr. Lucie Germain’s supervision, Laurence Cantin-Warren obtained the CIHR Undergraduate Studentship for her project Mobility, musculoskeletal health and arthritis 21 Neurosciences Axis Awards, acknowledgments and honours for the researchers Dr. Frédéric Bretzner received the prestigious Barbara-Turnbull Award for his exceptional work that aims to improve the health and quality of life of persons with spinal cord lesions and to discover relevant treatments. Every year, about 4 300 new cases of spinal cord injuries are observed in Canada. Dr. Bretzner and his team study the major pathways involved in motor transmission between the brain and the spinal cord. Motor rehabilitation can be performed in part through therapies designed to regenerate nervous cells from the brain to the spinal cord. Dr. Bretzner’s studies will therefore allow to identify the neuronal circuits to repair in order to promote functional recovery of walking following a medullar injury. The Barbara-Turnbull Award is bestowed annually to the investigator specialized in spinal cord injuries who was ranked best at the annual CIHR Operating Grants competition. Dr. Frédéric Calon’s work aims at demonstrating why diabetes increases the risk for a person to develop Alzheimer’s disease. According to his studies, these two pathologies might feed on one another due to one common denominator, namely insulin. Dr. Calon and his collaborators have discovered that in transgenic mice, the expression of three genes associated with Alzheimer’s entails insulin resistance in the whole body. When these mice are subjected to a fat-enriched diet, one can observe an increase in the level of beta-amyloid, a protein that causes Alzheimer’s disease, in the brain. An increased resistance to insulin as well as a decrease in memory are also observed. Surprisingly, the injection of a single dose of insulin canceled out the detrimental effects of nine months of the fat-enriched diet on the excess levels of soluble beta-amyloid in the brain. Moreover, memory test results improved following that treatment. Therefore, insulin might well be responsible for a lower production or a better disposal of beta-amyloid, thereby breaking the vicious circle that connects Alzheimer’s and diabetes. These results thus suggest that all factors that help to prevent type-2 diabetes, namely a wellbalanced diet, physical exercise and weight loss might have a protecting effect against Alzheimer’s disease. A study by Dr. Francesca Cicchetti, which was published in Annals of Neurology, shows that healthy tissues grafted upon the brain of Huntington’s disease patients in order to improve their neurological condition, develop themselves signs of that disease several years after the graft. Dr. Cicchetti proposes that scientists previously thought that genetic disorders such as Huntington’s disease were exclusively the product of an intracellular mutation, a phenomenon that eventually led to the manifestation of the disease. However, her study suggests instead that the mutated protein causing the disease can also propagate itself from cells carrying the mutated gene to healthy cells. This work not only improves our current understanding of Huntington’s disease, but may also lead to the development of novel therapies against that disorder, as well as other neurodegenerative diseases of the central nervous system and diseases associated with the propagation of pathological proteins, such as Parkinson’s and Alzheimer’s diseases. This discovery was the topic of a news article in the daily newspaper Le Soleil, as part of the Top 10 Major Breakthroughs of 2014 22 Changes affecting the brain and cognitive functions can be observed several years before the disease is diagnosed in patients that carry a gene for frontotemporal dementia. That was the finding reported in the study Genetic Frontotemporal Dementia Initiative (GENFI) published in the Lancet Neurology and to which collaborated Dr. Robert Laforce Jr., a researcher and investigator at the Clinique interdisciplinaire de mémoire du CHU de Québec. His work demonstrates that certain areas of the brain undergo modifications ten years before the appearance of the first symptoms of the disease. Changes affecting the cognitive functions have also been detected five years before a diagnosis of frontotemporal dementia was established. This study allows us to better understand the etiology of the disease in gene carriers and to consider certain avenues to halt progression of the disease. For instance, through the identification of biomarkers of the disease in at-risk and asymptomatic individuals, it might be realistically surmised that targeted treatments that would delay or minimize the outcomes of that type of dementia, might be offered some time in the future. Follow-up to that large-scale project is currently ongoing and is involving nearly thirty recruitment sites throughout nine different countries. Dr. Serge Rivest and his team, in partnership with the University of Calgary, has demonstrated, in a study published in the Journal of Experimental Medicine, that the turnover of myelin debris in the vicinity of neurons affected by multiple sclerosis is essential to their repair. One of the main manifestations of multiple sclerosis is the disappearance of the myelin sheath which surrounds neurons. In the absence of that sheath, transmission of nerve impulses is altered, thus causing motor and sensitivity problems. In order to halt this process and to allow repairing of the myelin sheath, the accumulation of myelin debris in the environment of the affected neurons must be eliminated. A long-lasting treatment should therefore permit the remyelination of neurons. Their work have demonstrated that the membrane receptor CX3CR1 appears to be essential to allow microglia to respond to myelin sheath damage and to attract other cells that are involved in its repair. If disposal of myelin debris does not proceed correctly, the myelin sheath cannot be regenerated. According to Dr. Rivest, these results clearly show the importance of stimulating microglia to trigger the latter response. One molecule that has the ability to perform the latter task is already known, namely fractalkine, a protein that is normally produced in the brain. The preferred hypothesis is that in multiple sclerosis patients, the process whereby myelin debris are eliminated could be restored, thus allowing neurons to be remyelinated. According to Dr. Jacques P. Tremblay, gene therapy might promote the emergence of a treatment for Friedreich’s ataxia within the next five years. Dr. Tremblay’s team is considering a treatment that would target the very cause of that disorder, i.e. a hereditary genetic abnormality that blocks the production of a protein known as frataxin. Nearly 6000 hereditary genetic disorders could benefit from gene therapy, which consists in repairing or modifying the genetic makeup. Awards, acknowledgments and honours for the students Philippe Bourassa, PhD candidate, was awarded a Didier-Mouginot Scholarship from the Fondation du CHU de Québec for his research project Treating Alzheimer’s disease via gene therapy targeting the RAGE and LRP-1 receptors in cerebral capillary endothelial cells. Peter Thériault, PhD student, was awarded a CIHR studentship for his project about Alzheimer’s disease. 23 Oncology Axis Awards, acknowledgments and honours for the researchers At the American Association of Physicists in Medicine’s Annual Meeting in Texas, Dr. Luc Beaulieu was appointed Fellow of that organization for his remarkable contributions in Medical Physics as well as his services to the Association. Lors du congrès annuel de l’American Association of Physicists in Medicine, au Texas, le Dr. Luc Beaulieu a été reçu Fellow de de cette association pour ses contributions remarquables en physique médicale, ainsi que pour les services rendus à l’Association. Drs. Luc Beaulieu, Philippe Després and Martin Simard were appointed Ambassadors for the organization of two meetings in Quebec City in 2014 at the Hommage aux Ambassadeurs evening which was organized by the Cercle des Ambassadeurs de Québec. In the case of Drs. Luc Beaulieu and Després, the award marked the organization of the International Workshop on Monte Carlo Techniques in Medical Physics, whereas for Dr. Simard, it underscored the Annual Meeting of the RNA Society. Dr. Jocelyne Chiquette was awarded the title of Woman of Distinction in the category “Health” at the YWCA’s Gala Femmes de Mérite (Women of Distinction Awards) event in 2014. This acknowledgment underscores her efforts and her tenaciousness as co-founder of the Centre des maladies du sein Deschênes-Fabia (CMS) (Deschênes-Fabia Breast Disease Centre) and as founder of the Centre des ressources en oncogénétique (ROSE) (Center for Oncogenetics Resources). This award aims at facilitating the visibility of women of passion and action who are transforming their personal and professional environment. The ROSE Centre, which is co-managed by Drs. Jocelyne Chiquette and Michel Dorval, received the Hommage aux innovations médicales Award from Université Laval. This honour aims to highlight innovating projects developed by members of the academic community who are contributing to the well-being of our society. This Centre also obtained a 500 000 $ grant from the Quebec Breast Cancer Foundation, which will be dedicated to the establishment of the ROSE Network in the Montreal, Saguenay and the Lower St. Lawrence regions. Its mission is to provide training specially tailored to the needs of health professionals, as well as to offer psychosocial support and information to families at risk for breast cancer. Drs. Jacques Côté and Jean-Yves Masson have received 500 000 $ from the Fondation du cancer du sein du Québec for a project aiming to find new ways to eradicate cancer cells. When defective, many processes can contribute to the genesis of a cancer cell. Homologous recombination, which is involved in DNA repair, is one of such processes. Dr. Côté and his team’s goals are to understand how certain modifications of the proteins encoded by the genes BRCA1/2 and PALB2 can modify a cell’s capacity to repair its DNA. Ultimately, this knowledge might be useful to reduce the viability of tumor cells. Furthermore, Dr. Côté was appointed member of the Medical Review Panel of the prestigious Gairdner Foundation. Results from a study realized by Les résultats d’une étude réalisée par la Dr. Caroline Diorio were featured in a Radio-Canada’s broadcast as well as in an article published by the BMC Public Health journal. The study in question demonstrates that a diet rich in sugar-rich foods and drinks is associated with a higher mammary density, a well-known risk factor for breast cancer. Research has 24 shown that women in whom 75% or more of their mammary tissue is dense have a 4- to 6-fold higher risk to develop a breast cancer than women whose mammary tissue is less or not dense. This represents the first time that a precise connection is under study between a sugar-rich diet, mammary density and menopausal status. Drs. Caroline Diorio, Vincent Fradet and Martin Simard have become Research Scholar–Junior 2, Clinical Research Scholar–Junior 2 and Research Scholar–Senior, respectively. These scholarships are awarded on an annual basis by the FRQS. The Laval/Nantes « Oxidative Stress and Endothelium » team, which is under the supervision of Drs. Jacques Huot, Isabelle Corre and François Paris (Nantes), literally made the headlines by being featured on la Une page of the Université de Nantes’ s website in May 2014. The European project p38 RadOx, which was the topic of a France-Canada cooperation in the field of cancerology, aims to understand the molecular pathways involved in the microvascular endothelium upon exposure to ionizing radiation. This project is geared towards the improvement of radiotherapy treatments. Dr. Jacques Huot was appointed Université Laval’s « interlocuteur privilégié » (preferred contact) for the Centre national de la recherche scientifique (CNRS)’s Institut des sciences biologiques. He was also nominated as Emeritus Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of Université Laval’s Faculty of Medicine. This acknowledgement underscores the exceptional activity noted for professors of the Department in the following areas: teaching, research and development, academic affairs and international standing. Dr. Jean-Yves Masson’s studies were the topic of an article entitled “Cancer Mysteries” (Les mystères du cancer) which was published in April 2014 in a special section of the daily newspaper Le Soleil (Giant Footsteps in Health – [Des pas de géant en santé]). Research by Dr. Masson and his team aims at a better understanding of the mechanisms of cellular DNA self-repair through the study of the mechanisms responsible for DNA recombination and genetic instability. The investigators wish to elucidate how certain enzymes and proteins with a protective role in the body provide a daily defense against various potentially damaging agents, and can recognize DNA damage for subsequent repair while preserving the integrity of the cell’s genetic makeup. An improved understanding of that phenomenon could help researchers to develop new strategies for curing cancer. Dr. Guy Poirier was awarded the diploma and title of Doctor honoris causa by the Université de Rennes. Dr. Poirier is one of the major specialists in the study of enzymes that play a major role in DNA damage signaling and its repair. A better insight in these DNA damage and cell death signaling phenomena may lead to substantial improvement in the diagnosis as well as treatment of very common pathologies such as cardiovascular diseases, diabetes, neurodegenerative diseases and several types of cancers. Dr. Poirier was also recipient of the CHU de Québec’s Prix Diamant (« Diamond Award ») in the category “Basic Research”, for his work. Dr. Josée Savard was awarded the 2014 Award of Excellence in Education from the Canadian Association of Psychosocial Oncology, which acknowledges her important contribution in psychosocial oncology training in Canada. Last year, DR. Savard was also appointed Fellow of the Canadian Society of Psychology, a distinction reserved to members whose contribution to the advances in that discipline was outstanding. Her work has mainly focused on the psychological aspects of cancer as well as the efficiency and accessibility of cognitive-behavioral interventions towards the improvement of quality of life in persons suffering from this disease. 25 Already acknowledged as a leader in his field of research, Dr. Martin Simard received the AndréDupont Award from the CRCQ. Since the very beginning of his career, his innovating studies have allowed to demonstrate the new role of a serine/arginine (Ser/Arg)-rich protein in the regulation of alternative splicing. Dr. Simard’s scientific expertise was then rapidly acknowledged by his peers in the field of research on the regulation of gene expression by short non-coding RNAs. His research aims on one hand at a deeper comprehension of how the microRNA metabolic pathway contributes to the effective maintenance of cellular homeostasis and on the other hand, to improve our knowledge of RNA interference in order to use that approach as a therapeutic tool. Dr. Bernard Têtu was the recipient of the 2014 edition of the Certificate of Merit Award from the Canadian Association for Medical Education. That award aims to promote medical education in the Canadian faculties of medicine as well as to acknowledge and reward the commitment of members of the teaching community towards medical education. At the CHU de Québec’s Prix Diamant evening event, Dr. Éric Vigneault was awarded the Prix Hommage from the Fondation du CHU de Québec for his unrelenting involvement over the last ten years in various charitable activities for the benefit of this foundation. Awards, acknowledgments and honours for the students Several students and postdoctoral trainees distinguished themselves at the FRQS Studentship national competition: Janie Allaire (Dr. Vincent Fradet’s laboratory), Ugo Dionne (Dr. Nicolas Bisson’s laboratory), Marie-Michelle Genois (Dr. Jean-Yves Masson’s laboratory), Dr. Paquito Bernard (Dr. Josée Savard’s laboratory) and Dr. Helori-Mael Gaude (Dr. Patrick Laprise’s laboratory). Ugo Dionne (Dr. Nicolas Bisson’s laboratory) has obtained a Frederick Banting and Charles Best Canada Graduate Scholarships from the CIHR Émilie Dubois (Dr. Jean-Yves Masson’s laboratory) was awarded the Award for Best Poster at the 26th Annual Meeting on Falconi anemia. The event, which took place in Washington, gathered together the best investigators in the world working in that field. Claire Dziengelewski (Dr. Josée Lavoie’s laboratory), and Charles-Antoine Collins-Fekete (Dr. Luc Beaulieu’s laboratory) were awarded studentships from the FRQNT. Mathieu Goulet (Drs. Luc Beaulieu and Louis Archambault’s laboratories) was selected ÉtudiantChercheur Étoile (Star Student-Investigator) for December 2014 by the FRQNT. Jean-François Montégiani (Dr. Philippe Després’s laboratory) was awarded the Correlative Imaging Council Walter Wolf Young Investigator Award for his significant contribution to the promotion of nuclear medicine and to the advances in the imaging and molecular therapy at the Society of Nuclear Medicine and Molecular Imaging’s Meeting. Madison Rilling (Dr. Louis Archambault’s laboratory) was awarded a NSERC Studentship. 26 Reproduction, Maternal and Child Health Axis Awards, acknowledgments and distinctions for the researchers Dr. Clémence Belleannée was recruited within the Axis as funded researcher in 2014. Her research program focuses on the function of the male reproductive system, and particularly on the modulation of the fertilizing potential of spermatozoa. Her work has applications to the diagnosis and treatment of male infertility. Although she just joined the Research Center, she has already obtained funding from the NSERC. The rate of Caesarean sections in Canada has considerably risen over the last decade. Dr. Emmanuel Bujold is one of the co-authors of a study that was conducted by his colleague Dr. Nils Chaillet and was published in the prestigious New England Journal of Medicine, which describes a randomized trial with the objective of reduce the number of C-sections practiced in the province of Quebec. Dr. Bujold also received a grant of nearly 1 million dollars from the CIHR, over five years, with the objective of predicting, as soon as the first trimester of pregnancy, the risks for preeclampsia and other pregnancy-related risks. The prestigious journal Nature Genetics published the results of a project that stemmed from a collaborative effort between paediatric cardiologists and investigators from the CHU de Québec and the CHU Sainte-Justine. Drs. Philippe Chetaille and Gregor Andelfinger have identified a new disorder, namely chronic atrial and intestinal dysrhythmia, a rare disease affecting the electrical function of muscle cells that are responsible for the autonomous contractions of the heart and intestine. Affected patients experience decelerating heartbeat, which often requires the implantation of a pacemaker. At the digestive level, a chronic intestinal pseudo-obstruction which often forces them to be exclusively fed intravenously. Drs. Chetaille’s and Andelfinger’s research has ked to establishing a genetic link between cardiac rhythm abnormalities and intestinal pseudo-obstruction. The two teams have developed a test that permits the diagnosis of that disease. Since the mutated gene that is responsible for the defect has now been identified, one can hope that therapeutic approaches can now be devised for these patients as well as for others affected by more frequent disorders, but whose mechanism might bear similarities with that elucidated through the present research. Dr. Pierre Déry, clinician-researcher and physician specialized in hospital paediatrics, was awarded the title of Professor Emeritus, the highest distinction and distinction that Université Laval bestows to one of its professors. Dr. Déry was also one of the architect of the implementation of the Centre Mère-Enfant at the beginning of the 2000s. Dr. Yannick Doyon has obtained a Young Investigator Installation – Junior 1 salary grant from the FRQS. He also obtained research awards from the NSERC, a Discovery Grant from the NSERC as well as a Discovery Award from the Banting Foundation. Dr. Doyon is working on the development of new therapies for rare metabolic disorders in children via in vivo gene correction. He also studies the molecular mechanisms of DNA repair. Dr. Isabelle Marc has obtained a 2.6 million $ from the CIHR for a five-year period to conduct a randomized trial on the effect of maternal supplementation with omega-3 fatty acids to reduce the incidence of bronchopulmonary dysplasia in the severely preterm newborns. 27 Over last year, researchers of the Axis have been highly sought-after speakers who distinguished themselves on the international stage: Dr. Robert Sullivan was invited to present his work on male infertility at international meetings in Shanghai, Sao Paulo and San Diego; Dr. Richard Kinkead was an invited speaker for the Journées de Recherche Respiratoire (Respiratory Research Days) in Bordeaux; Dr. Vincent Joseph gave a lecture entitled Altitude, Environment and Health at Mayor University in San Andres (Bolivia); at the World Congress of the International Society of Ultrasound in Obstetrics and Gynecology, Dr. Emmanuel Bujold has presented an innovative technique for the virtual biopsy of the placenta during the first trimester of pregnancy using 3D ultrasonography, which provides an estimate of placental vascularization within only a few seconds; and Dr. Jean-Claude Forest gave a lecture entitled Determinants of vitamin D status in pregnant women and neonates: Effect of season and lifestyle factors at the European meeting Clinical Chemistry and Laboratory Medicine. Dr. Jacques J. Tremblay was the invited speaker at the prestigious Endocrine Society Annual Meeting, which was jointly held with the International Congress of Endocrinology in Chicago in 2014, and which welcomed more than 10 000 participants. It is the most prestigious meeting in the world in the field of endocrinology. Dr. Tremblay’s studies have been featured in an article in the journal Molecular Endocrinology, which was reprised later in several editorials. Awards, acknowledgments and distinctions for the students Cécile Baldy, a graduate student under Dr. Richard Kinkead’s supervision, received the Award for Best Student Poster Presentation in the American Physiological Society’s Respiration section at the 2014 Experimental Biology Congress. Two students in Dr. Vincent Joseph’s laboratory distinguished themselves: Sofien Laouafa has obtained the Bourse d’Excellence Frontenac from the Consulate General of France in Quebec City; Ryma Boukari was awarded the Award of Excellence for her talk at the Journée de la recherche of Université Laval’s Faculty of Medicine, and an abstract of her presentation was selected for the Trainee Highlights Breakfast − Experimental Biology Mee^ng which was recently held in Boston. A paper (Daems et al, Mol Endocrinol) whose first author was a student in Dr. Jacques J. Tremblay’s laboratory was selected for publication by the Conseil Scientifique de la Société Française d’Endocrinologie, which distributes a Bulletin in which short abstracts from papers recently published in high-impact journals by investigators belonging to the francophone community (Newsletter, News & Views section). A PhD candidate under Dr. Jacques J. Tremblay’s supervision, Mickaël Di-Luoffo, received a Trainee Merit Award for the quality of his work and of his poster presentation at the American Society of Andrology Annual Meeting. Population Health and Optimal Health Care Practices Axis Awards, acknowledgments and distinctions for the researchers Dr. Michel Alary received the Prix Diamant en Recherche clinique for his project whose objective is the evaluation of the impact of the Avahan HIV Prevention Program on the Indian population. As the widest ranging program of its kind ever organized, it was targeting at-risk populations, and especially those involved in transactional sexual activities and injecting drug users. This intervention resulted in 28 a 50% decrease in HIV incidence, thereby preventing more than 600 000 cases of the infection over a 10-year period in the Indian states where the program had been implemented. Dr. Alary also coauthored an article about that project which was published in Lancet Global Health, and that demonstrated the excellent cost-efficiency ratio of the intervention in question. Dr. Marc Brisson and his team published a systematic review on the population impact of vaccination against HPV in Lancet Infectious Diseases. This study aggregates all data pertaining to the population impact of anti-HPV vaccination in more than 30 million individuals throughout nine countries, and was made possible thanks to a collaboration between thirty investigators and public health authorities in these countries. Dr. Brisson also co-authored a paper that was published in the British Medical Journal which suggests that a vaccination program against HPV using only two doses would have a better cost-efficiency ratio than a three-dose vaccination program. He also obtained a CIHR grant of 475 367 $ for a project entitled Reducing the burden of hospital-associated Clostridium difficile infections in Canada through optimal prevention policies: A multidisciplinary individual-based modeling approach. He was also among the principal investigators in the Canadian Immunization Research Network, which was supported by the CIHR with a 6,6 million $ grant support over a three-year period, on which Dr. Michel Alary is one of the co-investigators. Drs. Éric Dewailly’s and Christopher Fletcher’s work has been the focus of an article on their commitment towards the Aboriginal communities of Canada, in a special section of the daily newspaper Le Soleil that was published in April 2014. Dr. Dewailly maintained that although an invisible border insulates them from the rest of the country, we must help them to develop themselves further. Since the last five years, about four students of Aboriginal origin registered and were trained in either of the four Faculties of Medicine found in Quebec. He maintains the view that the solution to the enormous problems inherent to their education and health systems must come from themselves and entail the training of a whole generation of Aboriginal professionals, who would be more likely to understand properly the idiosyncratic complexities that are specific to their culture, something that non-Aboriginal professionals will never fully grasp. Sadly, Dr. Dewailly died following a tragic accident in June 2014. He was posthumously awarded the Association of Polar Early Career Scientists (APECS-Canada)-ArcticNet Student Association (ASA) Mentor Award. Drs. Marcemond and Marie-Josée Sirois, with their teams’ support, have published a paper on the functional impact of minor thoracic trauma in Annals of Surgery. Dr. Émond also obtained a 270 000 $ grant from the FRQS for a three-year period, for a project entitled Incidence and measure of the impact of emergency department-induced delirium. Drs. Anik Giguère and France Légaré were awarded a 450 000 $ grant from the Quebec Ministry of Economy, Innovation and Exports (MEIE) for the development and evaluation of teaching and knowledge transfer tools aimed at favouring the involvement of elderly patients suffering from dementia as well as their close family members and relations in decisions affecting them. Dr. Giguère also received a 300 000 $ grant from Networks of Centers of Excellence on Aging of Canada for a project entitled Health Care, Resource Utilization and Health Issue Models in Elderly Patients Receiving Palliative Care in Canada. This project also involves several other investigators in this Axis, including Drs. André Tourigny, René Verreault, Pierre J. Durand, France Légaré, Michèle Aubin et Alexis Turgeon. 29 Dr. Slim Haddad received a 1 million $ grant for a three-year period from the Global Health Research Initiative of Canada, a partnership program involving the CIHR, the International Development Research Centre (IDRC) and the Ministry of Foreign Affairs, Trade and Development (MFATD), for a project entitled Innovating and realistic interventions to improve the maternal, newborn and children health in West Africa. Dr. Michel Labrecque was awarded the prestigious Family Medicine Researcher of the Year Award from the College of Family Physicians of Canada. This award honours a scientist who played a key role in the definition, development and spreading of important family medicine concepts. During his 30year career, Dr. Labrecque has performed research in several areas including obstetrical and perinatal care, male sterilization and informed decision-making regarding the improvement of patient care. Drs. Danielle Laurin and Chantal Brisson received a CIHR grant of 781 921 $ over a 5-year period for a project entitled Cumulative exposure to psychosocial stress, inflammatory markers, telomers and cognitive function: A 20-year prospective study Dr. François Lauzier has received a 150 000 $ grant for a 2-year period for a study with a prospective cohort on pituitary disorders following a craniocerebral trauma. This project involves other researchers of the Axis, including Drs. Alexis Turgeon and Lynne Moore. Dr. France Légaré has obtained a 680 555 $ grant for a four-year period for a project entitled Implementing shared decision making in interprofessional home care teams: a stepped wedge cluster randomized controlled trial. This project also involves two other researchers of the Axis, namely Drs. Sophie Desroches et Pierre J. Durand. Dr. Mélanie Lemire has obtained a Research Scholar-Junior 1 Grant for her project that aims to understand the benefits and risks of homeland-based feeding in Aboriginal Peoples of Quebec. Dr. Michel Lucas provided an update on the dangers of excessive sugar consumption in five reports published in the daily newspaper Le Soleil and also broadcasted on Radio-Canada. He was also involved on a regular basis in the written and electronic press in the promotion of a healthy diet. Dr. Lucas organized a meeting involving two authorities in the field of diet-related disorders: Dr. Robert H. Lustig, from the University of California (Los Angeles), and Dr. Daniel Ludwig from Harvard University The most recent results from their research on the impact of refined sugar consumption demonstrate that it is not only associated with weight gain, obesity, type-2 diabetes, cardiac problems and hypertension, but also with an insidious effect that brings people to increase such consumption even further, a phenomenon that can be compared to tobacco dependence. The scientist also evokes the sobering reality of an actual sugar consumption epidemics that is mainly due to the ultraaggressive marketing of the relevant companies. Dr. Lucas also published as first author a paper entitled Social integration and suicide mortality among men: 21-year cohort study of U.S. health professionals in the Annals of Internal Medicine. This article was accompanied by an editorial. Dr. Alexis Turgeon and the Canadian Critical Care Trials Group received a 1 500 000 $ grant from the CIHR for a five-year period. Dr. Turgeon is one of the principal investigators on this grant. This grant will allow the investigators in the intensive care field throughout Canada to conduct their research projects under better conditions with the help of new infrastructures, including investigators of the CHU de Québec Research Centre, and especially Drs. François Lauzier and Patrick Archambault, as well as young investigators such as Drs. Michaël Chassé and Maude St-Onge. The CHU de Québec Research Centre’s Critical Care Trials Group is the most important in Quebec, and one of the main 30 centers of this type in Canada. Dr. Turgeon also co-authored an article entitled Age of Transfused Blood in Critically Ill Adult, which was published in the prestigious New England Journal of Medicine. The Centre of Excellence on Aging of Quebec (CEAQ) was honored twice by the health care community by receiving the Award of Excellence from the Réseau de la santé et des services sociaux, as well as the Prix Innovation clinique Banque Nationale (National Bank’s Clinical Innovation) Award from the l’Ordre régional des infirmières et infirmiers du Québec. Dr. Philippe Voyer and his team offer pioneering solutions to the challenge created by population aging. In the face of the needs expressed in various clinical settings, a team specialized in care for the elderly and that offers advisory-role services, clinical mentoring and second-tier health care, has been created. Confident in the autonomy of the field actors, this team aims to establish a collaboration between its members and the relatives. Since 2010, the mentoring team has trained more than 200 nurse-mentors in 51 different clinical settings. This approach, which is unique in Canada, permits the efficient treatment of persons exhibiting behavioral and psychological symptoms of dementia and to prevent hospitalizations. Awards, acknowledgments and distinctions for the students Marie Beaudin, who is supervised by Dr. Danielle Laurin, has received a Canada Graduates Scholarship for a Master’s training (CGS-M) from the CIHR Mirjam Garvelink, a student under the supervision of Dr. France Légaré, has obtained a Postdoctoral Training Scholarship from the FRQS in a competition where she finished fifth out of 138 candidates. Katia Giguère, Master’s student in epidemiology under Dr. Michel Alary’s supervision, has obtained the Éric-Dewailly Award from the CHU de Québec for her project Validation of the self-reported use of condoms in sex workers in Benin. Mahée Gilbert Ouimet, a student under Dr. Chantal Brisson’s supervision; Catherine Girouard, a student under Dr. Jocelyne Moisan’s supervision; Carlotta Lunghim a student under Dr. Line Guénette’s supervision; and Flore Morneau, a student co-supervised by Dr. Sylvie Dodin, each obtained an FRQS Postdoctoral Training Scholarship. Matthew Menear, a student under Dr. France Légaré’s supervision, has obtained three postdoctoral training scholarships, namely from the CIHR, the FRQS et from the Knowledge Translation (KT) Network of Canada. Xavier Trudel, a student who completed his PhD training under Dr. Chantal Brisson’s supervision, obtained scholarships from the CIHR and the FRQS to pursue a postdoctoral training in the United Kingdom. Dr. Sindy Magnan, whose thesis director is Dr. Alexis Turgeon, was awarded an FRQS-MSSS’s Resident Physician Health Research Career Training Scholarship for his Master’s training. 31 The Researchers Endocrinology and Nephrology Axis Regular Researchers Agharazii, Mohsen Barbier, Olivier Bergeron, Jean Bertrand, Nicolas Biron, Éric Caumartin, Yves Couture, Patrick De Serres, Sacha Doillon, Charles Droit, Arnaud Durocher, Francine Gagnon, Claudia Gobeil, Stéphane Guillemette, Chantal Isenring, Paul Adjunct Researchers Bachelard, Hélène Bélanger, Alain Cusan, Leonello D’Amours, Martin Gangloff, Anne Labrie, Fernand Lefebvre, Jean Affiliated Researchers Gomez, José-Luis Julien, Pierre Labrie, Claude Larivière, Richard Lebel, Michel Lévesque, Éric Lin, Sheng-Xiang Michou, Laeticia Poirier, Donald Richard, Darren E. Robitaille, Julie Rudkowska, Iwona Simard, Jacques R. St-Amand, Jonny Vohl, Marie-Claude Weisnagel, Stanley John Luu-The, Van Mac-Way, Fabrice Marette, André Pérusse, Louis Poirier, Luc Tchernof, André Poulin, Richard Honorary Researcher Audette, Marie 32 Infectious and Immune Diseases Axis Regular Researchers Aoudjit, Fawzi Barabé, Frédéric Bergeron, Michel G. Bessette, Louis Boilard, Éric Boivin, Guy Boulianne, Nicole Bourgoin, Sylvain Brown, Jacques P. Corbeil, Jacques De Serres, Gaston De Wals, Philippe Dionne, Marc Dubé, Ève Estaquier, Jérôme Fernandes, Maria José Flamand, Louis Fortin, Paul R. Gilbert, Caroline Gilca, Rodica Adjunct Researchers Baz Etchebarne, Mariana Boucher, François D. Côté, Louise Garenc, Christophe Moineau, Sylvain Gilca, Vladimir Gosselin, Jean Leclerc, Denis Marceau, François Naccache, Paul. H. Ouellette, Marc Papadopoulou, Barbara Pelletier, Martin Poubelle, Patrice Pouliot, Marc Provost, Patrick Richard, Dave Roy, Paul H Sato, Sachiko Sauvageau, Chantal Sellam, Adnane Sévigny, Jean Tessier, Philippe Tremblay, Michel J. Trottier, Sylvie Rouhabia, Mahmoud Senay, Hélène Vachon, Marie-Louise Wagner, Éric Honorary Researcher Beauchamp, Denis 33 Regenerative Medicine Axis Regular Researchers Auger, François A. Berthod, François Boisselier, Élodie Bolduc, Stéphane Fortin, Marc-André Fradette, Julie Germain, Lucie Gros-Louis, François Guérin, Sylvain L. Hermawann, Hendra Landreville, Solange Laroche, Gaétan Mantovani, Diego Moulin, Véronique Pernet, Vincent Pouliot, Roxane Proulx, Stéphanie Rochette, Patrick Salesse, Christian Zhang, Ze Adjunct Researchers Bazin, Richard Douville, Yvan Fortin, Michel Goulet, Francine Khuong, Hélène Thida Labbé, Raymond Maciel, Yvan Ruel, Jean Affiliated Researchers Cloutier, Réjean Desnoyers, Serge Dion, Yves-Marie Fruteau-de-Laclos, Bernard Giasson, Claude J. Guidoin, Robert G. Lamontagne, Jean Laughrea, Patricia Ann Lopez-Vallé, Carlos-Antonio Rousseau, Alain 34 Neurosciences Axis Regular Researchers Bouchard, Jean-Pierre Bretzner, Frederic Calon, Frédéric Cicchetti, Francesca Côté, Claude H. Di Paolo, Thérèse Drolet, Guy Dupré, Nicolas Frenette, Jérôme Guertin, Pierre Hébert, Sébastien Lacroix, Steve Laforce, Robert Jr Lévesque, Georges Mackey, Ariane Michaud, Karine Planel, Emmanuel Puymirat, Jack Rangachari, Manu Raymond, Vincent Rivest, Serge Rouillard, Claude Samadi, Pershia Savard, Pierre Schneider, Cyril Shah, Girish Soulet, Denis Tremblay, Jacques P. Tremblay, Marie-Ève Vallières, Luc Adjunct Researchers Audet, Marie-Ève Cantin, Léo Chantal, Sophie Mercier, David Oueslati, Abid Paquet, Jérôme Pelletier, Georges Prud’homme, Michel Sato, Masahiko Skuk, Daniel Affiliated Researchers Bouchard, Rémi W. Brunet, Denis Camden, Marie-Christine De Léan, Jacques Desbiens, Richard Dionne, Annie Émond, François Gariépy, Jean-Luc Grenier, Sophie JahJah, Laïla Langlois, Mélanie Lapointe, Benoît Lavoie, Pascale Milot, Geneviève Picard, Claude Savard, Martin Thibault, Manon Thomas, Tina Turcotte-Jean-François Verreault, Steve Verret, Louis Verret, Simon 35 Oncology Axis Regular Researchers Anderson, Alan Archambault, Louis Bachvarov, Dimcho Bairati, Isabelle Beaulieu, Luc Beauregard, Jean-Mathieu Bélanger, Luc Bilodeau, Steve Bisson, Nicolas Brisson, Jacques Caruso, Manuel Charron, Jean Chiquette, Jocelyne Côté, Jacques Dagnault, Anne Desbiens, Christine Desbiens, Jean-François Després, Philippe Diorio, Caroline Dorval, Michel Dumont, Serge Fillion, Lise Fortin, Sébastien Fradet, Vincent Fradet, Yves Gagnon, Bruno Gagnon, Pierre Gaudreault, René C. Huot, Jacques Huot, Marc-Étienne Jeannotte, Lucie Lacombe, Louis Landry, Jacques Laprise, Patrick Lavoie, Josée N. Lavoie, Mireille Lemieux, Julie Marceau, Normand Masson, Jean-Yves Maunsell, Elizabeth Mazroui, Rachid Meyer, François Moss, Thomas Nourani, Amine Plante, Marie Poirier, Brigitte Poirier, Éric Poirier, Guy G. Pouliot, Frédéric Provencher, Louise Savard, Josée Simard, Martin Têtu, Bernard Vigneault, Éric Adjunct Researchers Blais, Marie-Claude Caplette-Gingras, Aude Germain, Isabelle Hancock, Ronald Martin, André-Guy Picard, Louise Séguin, Carl Trudel, Dominique Affiliated Researchers Dionne, Anne Jacob, Simon Sanschagrin, François 36 Reproduction, Maternal and Child Health Axis Regular researchers Bairam, Aida Bilodeau, Jean-François Bujold, Emmanuel Carreau, Madeleine Doyon, Yannick Elowe, Sabine Faure, Robert Louis Forest, Jean-Claude Fortier, Michel A. Giguère, Yves Guimont, Chantal Joseph, Vincent Kinkead, Richard Lambert, Raymond D. Leclerc, Pierre Marc, Isabelle Michon, Bruno Pieboeuf, Bruno Soliz, Jorge Sullivan, Robert Tessier, Réjean Tremblay, Jacques J. Tremblay, Yves Viger, Robert Scott Adjunct Researchers Caouette, Georges Chetaille, Anne-Laure Chetaille, Philippe Daigneault, Patrick Déry, Pierre Dugas, Marc-André Gekas, Jean Houde, Christine Laberge, Philippe Laframboise, Rachel Lebœuf, Mathieu Weiss, Mathew John Affiliated Researchers Beaulac-Baillargeon, Louise Bourdages, Macha Honorary Researchers Laberge, Claude Tremblay, Roland R. 37 Population Health and Optimal Health Care Practices Axis Regular researchers Abdous, Belkacem Alary, Michel Aubin, Michèle Ayotte, Pierre Bélanger, Richard Brisson, Chantal Brisson, Marc Caron, Christian Corbeil, Philippe Dallaire, Clémence Després, Carole Desroches, Sophie Dewailly, Eric Dionne, Clermont Dodin, Sylvie Duchesne, Thierry Durand, Pierre J. Émond, Marcel Éthier, Sophie Fletcher, Christopher Frémont, Pierre Gagné, Camille Gagnon, Marie-Pierre Giguère, Anik Giroux, Dominique Godin, Gaston Grégoire, Jean-Pierre Guénette, Line Guillaumie, Laurence Haddad, Slim Labrecque, Michel Landreville, Philippe Lauzier, François Lauzier, Sophie Lavoie, André Légaré, France Le Sage, Natalie Levallois, Patrick Lévesque, Benoît Lucas, Michel Moisan, Jocelyne Moore, Lynne Muckle, Gina Ouimet, Mathieu Provencher, Véronique Riva, Mylène Roch, Geneviève Rousseau, François Sévigny, Andrée Simoneau, Martin Sirois, Caroline Sirois, Marie-Josée Teasdale, Normand Tourigny, André Turgeon, Alexis Verreault, René Vézina, Michel Voyer, Philippe Witteman, Holly Adjunct researchers Archambault, Patrick Beaulieu, Dominique Berthelot, Simon Bourbonnais, Renée Côté, Luc Demers, Louis Dogba, Maman A. D. Joyce Drolet, Mélanie Fortin, Jean-Paul Fredette, Marie-Josée Gagnon, Johanne Kröger, Edeltraut Laflamme, Nathalie Lapointe, Jean Laurin, Danielle Lemire, Stéphane Lessard, Martin Milot, Alain Morin, Michèle Ouellet, Marie-Christine Poitras, Julien Trottier, Vincent Vallières, Annie 38 Affiliated researchers Bélanger, Diane Gosselin, Pierre Guilbert, Edith Clinical Researchers – Extradepartmental Research Anctil, Jean-Louis Audet, Jean Audet, Nathalie Beaudoin, Jacques Bédard, Martin Bélanger, Mario Bélanger, Sylvie Béliveau, Patrick Bellemare, Guy Belzile, Étienne Bergeron, Dan Bergeron, Éric Bergeron, Marc Bitera, Raphaël Blanchet, Maude Boily, Marie-Claude Bolduc, Pierre Bonin, Lucie Bouchard, Carl Bouchard, Marc Bradette, Marc Cantin, Guy Caron, Louis Cinq-Mars, Benoît Claveau, Joël Cloutier, Stéphanie Côté, Fabien Côté, François Côté, Gary Côté, Isabelle Côté, Marc-André Couture, Félix d’Amours, Pierre Dallaire, Chrystian Danjou, Christine Daris, Marleen Delage, Robert Demers, Christine Demers, Mimi Des Marchais, Béatrice Deschenes, Louise Desjardins, Josée Desmeules, Simon Desrochers, Denis Dion, Nicolas Dion, Norbert Dionne, Christine Dorion, Anita Douville, Pierre Doyle, Catherine Drolet, Yvan Drouin, Jean Dubé, Réjean Dubuc, Benoît Duchesne, Nathalie Duguay, Pierre Dujardin, Thierry Eramian, Douglas Filion, Alain Fillion, Nancy Fortin, André Fortin, Marie-Pierre Frenette, Lyne Gagné, Élizabeth Gagnon, Hélène Gallagher, Geneviève Gilbert, Martin Goulet, Dominique Gourdeau, Alain Grégoire, Jean 39 Grégoire, Philippe Grenier, André Hallé, Pierre Hébert, Marc Houde, Gaétan Houde, Isabelle Joyal, Maryse Lachance, Jean-Guy Lajoie, Caroline Lalancette, Marc Lalonde, Gilles Landry, Pierre-Éric Langlais, Mario Langlois, Serge Laroche, Vincent Larouche, Jean-François Larouche, Valérie Lavoie, André Lavoie, Sylvain Leblond, Anne-France Leblond, Pierre-F. Lebouthiller, Pierre Leclerc, Pierre Leduc, Yvan Lépine, Jean-Marc Letartre, Laurence Lévesque, Denis Lévesque, Pierre Loungnarath, Vilayvong Lowndes, Catherine Macoir, Joël Mailloux, Jacques R. Major, Diane Marceau, Danièle Marquis, François Martel, Nadine Molgat, Yvonne Morin, Carol Morin, Jacques Nadeau, Marie-Josée Nadeau, Sylvie Nicole, Pierre Noël, Réal Ouellet, Pierre Paquet, Claudie Paquin, Robert Paradis, Alain Paré, Pierre Parent, Martin Pelet, Stéphane Pellerin, Hélène Pelletier, René Plamondon, Jacques Potvin, Jean-Michel Poulin, Jean-François Poulin, Marie-Josée Poulin, Stéphane Provençal-Belleau, France Renaud, Marie-Claude Rhainds, Marc Rhéaume, Caroline Rivard, Georges B Rodès Cabau, Joseph Rouleau, Michel Roy, Jean-François Roy, Louis Roy, Marie-Claude Roy, Michel Saikali, Stéphan Shields, Claude Shriqui, Christian Simard, Isabelle Sirois, Marthe Soucy, Jacques Talbot, Paul Tessier, Claude Tessier, Yves Tiguert, Rabi Tourville, Éric Tremblay, Benoît Tremblay, Daniel Trépanier, Claude Truchon, René Turmel, André Vaillancourt, Lucie Valcourt, Annie-Claude Vallières, Isabelle Vézina, Carmen Villeneuve, Josée Vincent, Pierre 40 List of abbreviations, initials and acronyms used in this document ADRIQ CEAQ CEVQ CFI CHUL CIHR CMS CNRS CQDM CR CRCQ CREMOGH FPQIS FRQNT FRQS HDQ HEJ HSFA HSS IDRC III INFF LOEX MFATD MEIE MFEQ MSSS NIH NSERC Q-CROC ROSE Association pour le développement de la recherche et l’innovation du Québec Center of Excellence on Aging of Quebec Centre d’excellence sur le vieillissement de Québec (Center of Excellence on Aging of Quebec) Canadian Foundation for Innovation Centre hospitalier de l’Université Laval Canadian Institutes of Health Research Centre des maladies du sein (Breast Diseases Center) Centre national de la recherche scientifique Consortium québécois sur la découverte du médicament (Quebec Consortium for Drug Discovery) Centre de recherche (Research Centre) Club de Recherches Cliniques du Québec Centre de recherche en endocrinologie moléculaire et oncologique et génomique humaine (Oncology, Molecular Endocrinology and Human Genomics Research Center) Fonds de partenariat pour un Québec innovant et en santé (Partnership Fund for an Innovating and Healthy Quebec) Fonds de recherche du Québec – Nature et technologies Fonds de recherche du Québec – Santé Hôtel-Dieu de Québec Hôpital de l’Enfant-Jésus Hôpital Saint-François d’Assise Hôpital Saint-Sacrement International Development Research Centre Institute of Infection and Immunity Institute of Nutrition and Functional Foods Laboratoire d’organogénèse expérimentale Ministry of Foreign Affairs, Trade and Development (Canada) Ministry of Economy, Innovation and Exports (Québec) Ministère des Finances et de l’Économie du Québec Ministère de la Santé et des Services sociaux National Institutes of Health Natural Sciences and Engineering Research Council of Canada Quebec-Clinical Research Organization in Cancer Centre de ressources en oncogénétique pour le soutien et l’éducation des familles à risque de cancer du sein (Oncology Resources Centre for the Support and Education of Families at Risk of Breast Cancer) 41 Publications Endocrinology and Nephrology Axis Adamo KB, Shen GX, Mottola M, Nascimento S, Jean-Philippe S, Ferraro ZM, Nerenberg K, Smith K, Chari R, Gaudet L, Piccinini-Vallis H, Wolcott C, McDonald S, Atkinson S, Godbout A, Robitaille J, Davidge S, Gruslin A, Prud'homme D, Stacey D, Rossiter M, Dodd J. Obesity Prevention from Conception: A Workshop to Guide the Development of a PanCanadian Trial Targeting the Gestational Period. Nutr Metab Insights, 2014. 7:7-18. Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Alonso MR, Dennis J, Wang Q, Bolla MK, Meyer KB, Menendez-Rodriguez P, Hardisson D, Mendiola M, Gonzalez-Neira A, Lindblom A, Margolin S, Swerdlow A, Ashworth A, Orr N, Jones M, Matsuo K, Ito H, Iwata H, Kondo N, kConFab Investigators, Australian Ovarian Cancer Study Group, Hartman M, Hui M, Lim WY, Iau PT, Sawyer E, Tomlinson I, Kerin M, Miller N, Kang D, Choi J, Park SK, Noh D, Hopper JL, Schmidt DF, Makalic E, Southey MC, Teo SH, Yip CH, Sivanandan K, Tay W, Brauch H, Bruning T, Hamann U, Genica Network, Dunning AM, Shah M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Schmidt MK, Broeks A, Rosenberg EH, van't Veer LJ, Fasching PA, Renner SP, Ekici AB, Beckmann MW, Shen C, Hsiung C, Yu J, Hou M, Blot W, Cai Q, Wu AH, Tseng C, Van Den Berg D, Stram DO, Cox A, Brock IW, Reed MW, Muir K, Lophatananon A, StewartBrown S, Siriwanarangsan P, Zheng W, Deming-Halverson S, Shrubsole MJ, Long J, Shu X, Lu W, Gao Y, Zhang B, Radice P, Peterlongo P, Manoukian S, Mariette F, Sangrajrang S, McKay J, Couch FJ, Toland AE, TNBCC, Yannoukakos D, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Marme F, Burwinkel B, Guenel P, Truong T, Sanchez M, Mulot C, Bojesen SE, Nordestgaard BG, Flyer H, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Mannermaa A, Kataja V, Kosma V, Hartikainen JM, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Wang X, Olson JE, Vachon C, Purrington K, Giles GG, Severi G, Baglietto L, Haiman CA, Henderson BE, Schumacher F, Marchand LL, Simard J, Dumont M, Goldberg MS, Labreche F, Winqvist R, Pylkas K, Jukkola-Vuorinen A, Grip M, Devilee P, Tollenaar RA, Seynaeve C, Garcia-Closas M, Chanock SJ, Lissowska J, Figueroa JD, Czene K, Eriksson M, Humphreys K, Darabi H, Hooning MJ, Kriege M, Collee JM, Tilanus-Linthorst M, Li J, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Nevanlinna H, Muranen TA, Aittomaki K, Blomqvist C, Bogdanova N, Dork T, Hall P, Chenevix-Trench G, Easton DF, Pharroah PD, Arias-Perez JI, Zamora P, Benitez J, Milne RL. FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. Br J Cancer, 2014. 110:10881100. Agharazii M, St-Louis R, Gautier-Bastien A, Ung RV, Mokas S, Lariviere R, Richard DE. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am J Hypertens, 2015. 28:746-755. Akhabir L, Berube JC, Bosse Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Pare PD, Postma DS, Sandford AJ. Lung expression quantitative trait loci data set identifies important functional polymorphisms in the asthma-associated IL1RL1 region. J Allergy Clin Immunol, 2014. 134:729-731. Alesawi A, Nadeau G, Bergeron A, Dujardin T, Lacombe L, Caumartin Y. Cystatin C for early detection of acute kidney injury after laparoscopic partial nephrectomy. Urol Ann, 2014. 6:298-304. 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Zhang P, Lavoie PM, Lacaze-Masmonteil T, Rhainds M, Marc I. Omega-3 long-chain polyunsaturated fatty acids for extremely preterm infants: a systematic review. Pediatrics, 2014. 134:120-134. 120 Contact Information www.crchudequebec.ulaval.ca Board of Directors (Executive Office) CHUL 2705, boul. Laurier, bureau T4-44 Québec (Québec) G1V 4G2 418 525-4461 [email protected] Hôpital de l’Enfant-Jésus 1401, 18e Rue Québec (Québec) G1J 1Z4 418 649-0252, poste 66142 Hôpital du Saint-Sacrement 1050 Chemin Sainte-Foy Québec (Québec) G1S 4L8 418 682-7663 Hôpital Saint-François d’Assise 10, rue de l’Espinay Québec (Québec) G1L 3L5 418 525-4444, poste 53714 L’Hôtel Dieu de Québec 11, côte du Palais Québec (Québec) G1R 2J6 418 691-5281 121 Acknowledgments to our partners 122