CV (David P Labbé) 21-01-2016 - Association des communicateurs

Transcription

DAVID P. LABBÉ, Ph.D., agr., chm.
8, Buckley Avenue, APT 2
Boston, Massachusetts, USA
02130
Phone: (617) 632-3596
EMail: [email protected]
LinkedIn: ca.linkedin.com/in/labbedavid
RESEARCH SCHOLAR
Experienced scientist specialized in resolving multidiciplinary questions in collaborative settings. Has proven able to
carry out research projects and produce publications of high quality in the Cancer and Food Sciences research fields.
Demonstrated abilities to communicate scientific issues to both a professional and a scientific audience.
Possess international experiences (Canada, France, United States) and a good basis in management.
EDUCATION
Harvard Medical School (Postdoc)
October 2013Harvard University, Dana-Farber Cancer Institute, Boston, USA
Research thematic: Deconvulting the role of diet and obesity in prostate cancer susceptibility through
epigenomics
Supervisor, Dr Myles Brown
Experimental Medicine (Ph.D.)
2013
McGill University, Goodman Cancer Research Centre, Montréal
Ph.D. thesis: Deciphering the regulation and role of protein tyrosine phosphatase 1B in prostate
cancer
Supervisor, Dr Michel L. Tremblay
Chemistry, specialization in biochemistry (M.Sc.)
2008
Université du Québec à Montréal/Hôpital Sainte-Justine, Montréal
Master thesis: Les flavonoïdes d’origine alimentaire et le cancer – Inhibition de l’angiogenèse
tumorale et du potentiel invasif des médulloblastômes
Supervisor, Dr Richard Béliveau
• Master’s thesis accepted with an ”excellent” rating
• Degree obtained with honours
Administration (certificate)
Université Laval, Québec
• Specialization in management
2007
Food Sciences, experience abroad (B.Sc.A.)
Université Laval, Québec
• Semester at the ”Polytech’Montpellier”, Montpellier, France
• Specialization in chemistry
2006
BILINGUAL: French and English
PROFESSIONAL ORDERS:
• Chemist, member of the “Ordre des chimistes du Québec”
• Agrologist, member of the “Ordre des agronomes du Québec”
20082006-
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AWARDS AND PRIZES
Research awards
Award name
Organization
Post-Ph.D. Fellowship (ranked 2nd over 406 applications)
Rolande and Marcel Gosselin Graduate Studentship
McGill Integrated Cancer Research Training Program
Frederick Banting and Charles Best doctoral research award
Doctoral research award (declined)
Master research award
Canada Graduate Scholarship – Master’s
Undergraduate Student Research Award
Internship award “Excellence”
CIHR
McGill University
CIHR/FRSQ
CIHR
FRSQ
FQRNT
NSERC
NSERC
Ordre des chimistes du Québec
NSERC
NSERC
Amount
150,000
11,000
12,000
105,000
60,000
15,000
17,500
5,625
5,000
5,625
5,625
Date
2013-2016
2011-2012
2011-2012
2008-2011
2008-2011
2007
2006
2006
2005
2004
2003
Prizes
Award name
Organization
Travel award
(Cold Spring Harbor meeting, Cold Spring Harbor, NY)
Graduate Research Enhancement & Travel (GREAT) Award
Travel award
(Europhosphatase 2011, Vienna, Austria)
Travel award
(FASEB meeting, Steamboat Springs, CO)
Phil Gold Scientist in Training Award
(3rd best poster presentation)
National Student Research Poster Competition
(Winnipeg, Manitoba)
Travel award
(Cold Spring Harbor meeting, Cold Spring Harbor, NY)
Best poster presentation
(Centre de recherche du CHU Sainte-Justine, Montréal)
Second rank
(Student Challenge opposing 7 canadian universities)
Second best poster presentation
McGill Integrated Cancer
Research Training Program
McGill University
McGill Integrated Cancer
Research Training Program
Canderel
Amount
Date
1,000
2012
1,500
1,000
2012
2011
500
2010
100
2009
-
2009
Canderel
500
2009
CHU Sainte-Justine
150
2007
-
2006
100
2005
MISAM
CIHR (declined)
Can. Inst. Food. Sci. and Tech.
FAV Health 2005
Academic awards
Award name
Organization
Graduate Excellence Fellowship
Principal’s Graduate Fellowship
Provost’s Graduate Fellowship
Junior/Senior Scholarship
Excellence award
Award
Junior/Senior Scholarship
Excellence award
Studentship for studies abroad, France
Excellence award
Excellence award
Excellence award
Excellence award
Excellence award
Summer English language program
McGill University
McGill University
McGill University
Institute of Food Technologist (USA)
Canadian Inst. of Food Science and Tech.
Fondation de technologie laitière du Québec inc.
Institute of Food Technologist (USA)
Canadian Inst. of Food Science and Tech. (Québec)
Université Laval
Canadian Inst. of Food Science and Tech.
Promotion Agronomie 1965, Université Laval
Faculty (FSAA), Université Laval
Minister of Canadian Heritage
Amount
1,500
2,500
5,500
1,000
1,000
500
1,000
800
3,000
1,000
1,500
800
800
1,000
1,625
Date
2012
2009-2010
2008-2009
2006
2006
2006
2005
2005
2004
2004
2004
2004
2003
2002
2002
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EXPERTISE
•Food sciences
•Nutraceuticals
•Cell based assays
•Mouse models
•Protein tyrosine phosphatases
•Oncology - focus prostate cancer
•Translational research
•Epigenetics
•Metabolomics
SUPERVISORY EXPERIENCE
Attribute and supervise research activities
Laboratory employee (1); Biochemistry undergraduate student (1); Volunteer (1)
2010-2013
SPECIALIZED COURSE
Eukaryotic Gene Expression (Valedictorian)
• Cold Spring Harbor Laboratory, Cold Spring Harbor, USA
2014
RESEARCH EXPERIENCE
Development of a preconcentration method for green tea catechins
• Research internship (NSERC), Université Laval, Québec
Dr Laurent Bazinet
2006
Optimisation of an electrodialysis method for green tea catechins separation
• Research collaboration, Institut européen des membranes (IEM), Montpellier, France
Dr Philippe Sistat and Dr Laurent Bazinet
2005
Nutritional impact of chitosan on rats under a cholesterol and saturated fat-rich diet
• Exploratory study, Polytech’Montpellier, Université de Montpellier II, France
Dr Jean-Max Rouanet and Dr Bernard Possompes
2005
Green tea polyphenols electromigration with ultrafiltration membranes
Dr Laurent Bazinet
2004
Study on the maturation of cheese
• Industrial research internship, Les Fromages de l’isle d’Orléans, Québec
Dr Jacques Goulet
2004
Study on the green tea polyphenols electromigration potential
Dr Laurent Bazinet
2003
Production of emulsifier molecules by enzymatic means
• Research internship, Université Laval, Québec
Dr Jean-Christophe Vuillemard
2003
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SCIENTIFIC PUBLICATIONS
ARTICLES
1. Labbé, D.; Araya-Farias, M.; Tremblay, A.; Bazinet, L. Electromigration feasability of green tea
catechins, Journal of Membrane Science, 254 (2005) 101-109.
2. Labbé, D.; Tremblay, A.; Bazinet, L. Effect of brewing temperature and duration on green tea
catechin solubilization: basis for production of EGC and EGCG-enriched fractions, Separation and
Purification Technology, 49 (2006) 1-9.
3. Labbé, D.; Bazinet, L. Effect of membrane type on cation migration during green tea
electromigration and equivalent mass transported calculation, Journal of Membrane Science, 275 (2006)
220-228.
4. Bazinet, L.; Labbé, D.; Tremblay A. Production of green tea EGC- and EGCG-enriched fractions by
a two-step extraction procedure, Separation and Purification Technology, 56 (2007) 53-56.
5. Labbé, D.; Têtu, B.; Trudel, D.; Bazinet, L. Catechin stability of EGC- and EGCG-enriched tea
drinks produced by a two-step extraction procedure, Food Chemistry, 111 (2008) 139-143.
6. Lamy, S.; Beaulieu, É.; Labbé, D.; Bédard, V.; Moghrabi, A.; Barette, S.; Gingras, D.; Béliveau, R.
Delphinidin, a dietary anthocyanidin, inhibits platelet derived growth factor ligand/receptor
(PDGF/PDGFR) signaling, Carcinogenesis, 29(5) (2008) 1033-1041.
7. Lamy, S.; Bédard, V.; Labbé, D.; Sartelet, H.; Barthomeuf, C.; Gingras, D.; Béliveau, R. The dietary
flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through
inhibition of PDGFR-β phosphorylation, Cancer Prevention Research 1(6) (2008) 452-459.
8. Labbé, D.; Provençal, M.; Lamy, S.; Boivin, D.; Gingras, D.; Béliveau, R. The flavonols quercetin,
kaempferol and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration,
The Journal of Nutrition, 139(4) (2009) 646-652.
9. Boivin, D.; Labbé, D.; Fontaine, N.; Lamy, S.; Beaulieu, É.; Gingras, D.; Béliveau, R. The stem cell
marker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Src
and Fyn tyrosine kinase, Biochemistry, 48(18) (2009) 3998-4007.
10. Provençal, M.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.; Béliveau, R. c-Met
activation in meduloblastoma induces tissue factor expression and activity: effects cell migration,
Carcinogenesis, 30(7) (2009) 1089-1096.
11. Provençal, M.; Berger-Thibault, N.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.;
Béliveau, R. Tissue factor mediates the HGF/MET-induces anti-apoptotic pathway in
medulloblastoma cells, Journal of Neuro-Oncology, 97(3) (2010) 365-372.
Page 5 / 14
12. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.;
Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase that
promotes the progression of prostate cancer, Cancer Research, 72(6) (2012) 1529-1537.
*Contributed equally to the work
Top Story: Prostate Cell News, 3.03, January 27 2012
Comment: SciBX 5(7); doi:10.1038/scibx.2012.176, February 16 2012
Publication of the Month: Goodman Cancer Research Centre, January 2012
13. Trudel, D.; Labbé, DP.; Araya-Farias, M.; Doyen, A.; Bazinet, L.; Duchesne, T.; Plante, M.;
Grégoire, J.; Renaud, MC.; Bachvarov, D.; Têtu, B.; Bairati, I. A two-stage, single-arm, phase II study
of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian
cancer, Gynecologic Oncology, 131(2) (2013) 357-361.
Editorial comment: Obstetrical & Gynecological Survey, 69(4) (2014) 207-208
14. Labbé, DP.; Nowak, DG.; Deblois, G.; Lessard, L.; Giguère, V.; *Trotman, LC.; *Tremblay, ML.
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to
androgen receptor-regulation in metastatic tumors, Molecular Cancer Research (Rapid Impact), 12(2)
(2014) 184-189.
*Co-corresponding authors
Rapid Impact: Brief article of high impact, unusual significance, timeliness or novelty
Research Highlights: Molecular Cancer Research, 12(2) (2014) 165
Cover image: Front page of the February issue
Invited comment: Uro Today, Beyond the abstract (urotoday.com), July 1st 2014
15. Hardy, S.; Uetani, N.; Wong, NN.; Kostantin, E.; Labbé, DP.; Bégin, LR.; Mess-Masson, AM.;
Miranda-Saavedra, D.; Tremblay, ML. PRL-2 interacts with CNNM3 to control intracellular
magnesium levels and oncogenesis, Oncogene, 34(8) (2015) 986-995 [Epub ahead of print; doi:
10.1038/onc.2014.33 (March 17th 2014)].
16. Labbé, DP.; Uetani, N.; Vinette, V.; Aubry, I.; Migon, E.; Sirois, J.; Haigh, JJ.; Lessard, L.; Bégin,
LR.; Trotman, LC.; Paquet, M.; Tremblay, ML. PTP1B deficiency potentiates prostate cancer
invasiveness by sensitizing Pten-null tumors to high fat diet, Cancer Research, submitted.
17. Deblois, G.; Smith, H.; Tam, I.; Gravel, S-P.; Caron, M.; Savage, P.; Labbé, DP.; Bégin, LR.;
Tremblay, ML.; Park, M.; Bourque, G.; St-Pierre, J.; Muller, WJ.; Giguère, V. ERRα mediates metabolic
adaptations driving lapatinib resistance in breast cancer, Nature Communications, submitted.
18. Ebot, EM.; Gerke, T.; Labbé, DP.; Sinnott, JA.; Zadra, G.; Rider, JR.; Tyekucheva, S.; Wilson, KM.;
Kelly, RS.; Shui, IM.; Loda, M.; Kantoff, PW.; Finn, S.; Vander Heiden, MG.; Giovannucci, EL.; Brown,
M.; Mucci, LA. Gene expression profiling of human prostate tumors identifies chromatin regulation
as a molecular link between obesity and lethal prostate cancer, JAMA Oncology, submitted.
Page 6 / 14
19. *Labbé, DP.; *Zadra, G.; Yang, M.; Lin, CY.; Reyes, JM.; Cacciatore, S.; Ebot, EM.; Cotter, M.;
Creech, AL.; Jaffe, JD.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Chavarro, JE.; ★Loda, M.; ★Brown, M.
High fat diet enhances MYC-driven prostate cancer through epigenomic and metabolomics rewiring,
in preparation.
*Contributed equally to the work; ★Co-corresponding authors
REVIEWS
1. Trudel, D.; Labbé, DP.; Bairati, I.; Fradet, V.; Bazinet, L.; Têtu, B. Green tea for ovarian cancer
prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies,
Gynecologic Oncology, 126(3) (2012) 491-498.
2. Labbé, DP.; Zadra, G.; Ebot, EM.; Mucci, LA.; Kantoff, PW.; Loda, M.; Brown, M. Role of diet in
prostate cancer: The epigenetic link, Oncogene, 34 (2015) 4683-4691 [Epub ahead of print; doi:
10.1038/onc.2014.422 (December 22nd 2014)].
BOOK CHAPTERS
1. Labbé, DP.; Hardy, S.; Tremblay, ML. Protein tyrosine phosphatases in cancer: Friends and Foes!,
in Protein Phosphorylation in Health and Disease an issue of Progress in Molecular Biology and
Translational Science (Shenolikar, S. ed.), Academic Press, Chapter 10, 106 (2012) 253-306.
2. Labbé, DP.; Tremblay, ML. PTP1B : From metabolism to cancer, in Protein Tyrosine Phosphatases in
Cancer (Neel, BG. and Tonks, NK. eds.), Springer, Chapter 6, in press.
BROAD INTEREST PUBLICATIONS
1. Labbé, D. L’aspirine, un remède aux allergies alimentaires? Le Ligand, mars 2003, vol. 14, no 1, p. 3.
2. Labbé, D. Transformer bio, un noble défi! L’Actualité alimentaire, 2004, vol. 1, no 6, p. 42-43.
3. Labbé, D. Produire sans lait, sans œufs ou sans gluten : Un casse-tête nécessaire, L’Actualité
alimentaire, 2004, vol. 1, no 6, p. 44.
4. Labbé, D. Les technologies membranaires flirtent avec les nutraceutiques, L’Actualité alimentaire,
2005, vol. 2, no 1, p. 46-48.
5. Labbé, D. L’extraction de molécules bioactives, L’Actualité alimentaire, 2005, vol. 2, no 5, p. 44-47.
6. Labbé, D. La modélisation au service de l’optimisation, L’Actualité alimentaire, 2005, vol. 2, no 6, p.
42-44.
7. Labbé, D. S’afficher sans allergènes, L’Actualité alimentaire, 2006, vol. 3, n° 2, p. 52-55.
8. Labbé, D. Être à l’affût : un défi de pointe, L’Actualité alimentaire, 2006, vol. 3, n° 3, p. 46-49.
9. Labbé, D. Inflammation et cancer : Quand le système immunitaire se retourne contre soi, Sciences
express (UQÀM), 2008, vol. 7, n° 9.
Page 7 / 14
PATENTS
1. Bazinet, L.; Labbé, D.; Tremblay, A. Method for selectively and sequentially extracting catechins
from plant product. North American # US2005176939.
2. Bazinet, L.; Amiot, J.; Poulin, J.-F; Labbé, D.; Tremblay, A. Process and system for separation of
organic charged compounds. Worldwide #WO2005082495.
REVIEWER (peer-reviewed journal)
Current Oncology
Molecular Cancer Therapeutics (AACR)
Stem Cell International
201020142015-
PRESENTATIONS
INVITED SPEAKER
1. Labbé, D. Serions-nous tous mal nourris? Invited panelist at the “Forum des jeunes en sciences”,
Collège Montmorency, Laval (Québec), November 6th 2006.
2. Labbé, D. Sciences et médias : Information ou désinformation? 2nd “Colloque des chercheurs
étudiants et postdoctoraux de l’Institut des nutraceutiques et des aliments fonctionnels (INAF)”,
Château Bromont, Bromont (Québec), November 1-2, 2007.
3. Labbé, DP. Role of diet in prostate cancer: the epigenetic link. Prostate Cancer Foundation (PCF)
Young Investigators working group on Nutrition and Metabolism, Webinar, February 6th 2015.
4. *Labbé, DP. and *Ebot, EM. Role of diet in prostate cancer: the epigenetic link. 8th Annual MultiInstitutional Prostate Cancer Program Retreat (Sponsored by DF/HCC, FHCRC, JHMI, MSKCC and
UMCCC), Fort Lauderdale, Florida (USA), March 15-17, 2015.
*Shared presentation
5. Labbé, DP. Unraveling the role of diet in prostate cancer. SPORE/Program in Prostate Cancer
Research Seminar at the Fred Hutchinson Cancer Research Center, Seatle, Washington (USA), June
11th, 2015.
6. *Labbé, DP. and *Zadra, G. Targeting intra-tumor lipid metabolism and understanding the impact
of high fat diet-induced obesity on cancer metabolome and epigenome. Lipid metabolism and
metabolic alterations in prostate cancer, Dana-Farber Cancer Institute, Boston, Massachusetts (USA),
July 31st, 2015.
*Shared presentation
7. Labbé, DP. High fat diet enhances MYC-driven prostate cancer through epigenomic and
metabolomics rewiring. Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute,
Boston, Massachusetts (USA), October 2nd, 2015.
Page 8 / 14
ORAL PRESENTATIONS
1. Bazinet, L.; Labbé, D.; Tremblay, A. Effect of temperature and brewing duration on solubilization
of green tea catechins. First Natural Health Product Research Conference organized by the Natural
Health Product Research Society of Canada, Montréal (Québec), February 20-22, 2004.
2. Bazinet, L.; Labbé, D.; Tremblay, A. Production d’une fraction enrichie en EGCG du thé vert par
une procédure d’extraction en deux étapes. 72nd “Congrès de l’ACFAS, discipline chimie-physique,
inorganique et des surfaces”, UQAM, Montréal (Québec), May 13th 2004.
3. Labbé D.; Araya-Farias, M.; Tremblay A.; Bazinet L. Effet du type de membrane sur la migration
des cations au cours de l’électromigration de thé vert et le calcul des équivalents-masses transportés.
“Journée d’information scientifique et technique en génie agroalimentaire”, Saint-Hyacinthe
(Québec), March 23rd 2005.
4. Trudel, D.; Bairati, I.; Bazinet, L.; Labbé, D.; Plante, M.; Bachvarov, D.; Overall, C.; Jones, T.; Têtu,
B. Green tea intake for maintenance of complete remission in women with advanced stage ovarian
cancer. 45th “Journée scientifique annuelle Carlton-Auger”, Québec (Québec), October 12-13, 2007.
Published abstract: Annales de pathologie 28(1) (2008) 71-75.
5. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit la
surexpression du facteur tissulaire dans les médulloblastomes. 4th annual meeting of the “Centre de
Recherches Biomédicales (BioMed)”, Université du Québec à Montréal, Montréal (Québec), April 30th
2008.
6. Labbé, D. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the
amino-terminus domain of the androgen receptor. Journal Club, Goodman Cancer Research Centre,
McGill University, Montréal (Québec), November 26th 2010.
7. Labbé, D. PTP1B is regulated by the androgen receptor and plays a tumor-promoting role in
prostate cancer. Work In Progress (WIP) talk, Goodman Cancer Research Centre, McGill University,
Montréal (Québec) January 18th 2011.
8. *Labbé, D.; *Lessard, L.; Deblois, G.; Hardy, S.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;
Giguère, V.; and Tremblay, ML. Protein tyrosine phosphatase 1B is regulated by the androgen
receptor and plays a tumor-promoting role in prostate cancer. Europhosphatase 2011 (EMBO
Conference Series); Protein Phosphatases: From Molecules to Networks, Vienna, Austria, July 18-23,
2011.
9. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,
LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase associated
with tumor-promoting functions in prostate cancer. Phosphatases in Human Disease, Melbourne,
Australia, February 3-4, 2012.
Page 9 / 14
Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase
associated with tumor-promoting functions in prostate cancer. 12th Annual McGill Biomedical
Graduate Conference, Montréal (Québec), February 16th 2012.
11. Labbé, DP.; Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman,
LC.; Giguère, V.; Tremblay, ML. The 20q13 chromosomal region is androgen-regulated and amplified
in aggressive prostate cancer: focus on the oncogenic role of PTP1B. The 22nd Annual McGill Urology
Research Day, Montréal (Québec), April 18th 2012.
12. Labbé, DP. Deciphering the role of protein tyrosine phosphatase 1B (PTP1B) in the development
of prostate cancer induced by PTEN loss in mice. Work In Progress (WIP) talk, Goodman Cancer
Research Centre, McGill University, Montréal (Québec) June 4th 2013.
13. *Labbé, DP.; *Zadra, G.; Ebot, EM.; Lin, CY.; Reyes, JM.; Cacciatore, S.; Cotter, M.; Creech, AL.;
Jaffe, JD.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Loda, M.; Brown, M. High fat diet enhances MYCdriven prostate cancer through epigenomic and metabolomics rewiring. The 25th Annual McGill
Urology Research Day, Montréal (Québec), September 16th 2015.
14. Zolotarov, E.; Labbé, DP.; Nowak, DG.; Deblois, G.; Lessard, L.; Giguère, V.; Trotman, LC.;
Tremblay, ML. Multigenic studies on the prostate cancer genetic-susceptibility amplicon genes on
chromosome 20q13 to characterize the presence of additive or synergetic effect in metastatic tumors.
The 25th Annual McGill Urology Research Day, Montréal (Québec), September 16th 2015.
Jaffe, JD.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Loda, M.; Brown, M. High fat diet enhances MYCdriven prostate cancer through epigenomic and metabolomics rewiring. Dana-Faber Cancer Institute
11th Annual Postdoc and Graduate Student Retreat, Boston, Massachusetts (USA), September 18th
2015.
POSTER PRESENTATIONS
1. Labbé, D.; Tremblay, A.; Araya-Farias, M.; Bazinet, L. Séparation et purification des catéchines
d’une infusion de thé vert par électromigration. Poster presented at the “Alimentation fonctionnelle
et nutraceutiques : approches innovatrices en santé” meeting co-organized by the CQVB/INAF
during the 72nd “Congrès de l’ACFAS”, UQAM, Montréal (Québec), May 13th 2004.
2. Labbé, D.; Vignal, E.; Sistat, P.; Bazinet, L. Separation of green tea catechins by electrodialysis with
ultrafiltration membranes. Poster presented at the “International Symposium on Human Health :
effects of fruits and vegetables (FAV Health 2005)”, Québec (Québec), August 17-20, 2005.
Published abstract: Acta Hort. (ISHS) 744 (2007) 369-376.
Page 10 / 14
3. Labbé, D.; Tremblay, A.; Bazinet, L. Electromigration feasability of green tea catechins. Poster
presented at the “International Congress on Membranes and Membrane Processes (ICOM 2005)”,
Seoul (South Korea), August 21-25, 2005.
4. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénol
d’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the 3rd “Colloque
annuel Biomed”, UQAM, Montréal (Québec), May 2nd 2007.
5. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénol
d’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the XXIInd “Congrès
annuel de la recherche des étudiants gradués du Centre de recherche du CHU Sainte-Justine”,
Montréal (Québec), May 15-16, 2007.
6. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit la
surexpression du facteur tissulaire dans les médulloblastomes. Poster presented at the 4th “Colloque
annuel du Centre de Recherches Biomédicales (BioMed)” UQAM, Montréal (Québec), April 30th
2008.
7. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire, de
nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the 4th
“Colloque annuel du Centre de Recherches Biomédicales (BioMed) de l’Université du Québec à
Montréal”, Montréal (Québec), April 30th 2008.
8. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire, de
nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the
“XXIIIe Congrès annuel de la recherche des étudiants gradués et post-gradués du Centre de
recherche du CHU Sainte-Justine”, Montréal (Québec), June 12th 2008.
9. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras,
D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity:
Effects on cell migration. Poster presented at Phosphorylation, signaling & disease, Cold Spring
Harbor, New York (USA), May 12-16, 2009.
10. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras,
D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity:
Effects on cell migration. Poster presented at the Montréal International Symposium on Angiogenesis
and Metastasis (MISAM 2009), Montréal (Québec), June 11-12, 2009.
11. *Labbé, D.; *Lessard, L.; Bégin, LR.; Leloy, A.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Tremblay,
ML. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells. Poster
presented at the FASEB Summer Research Conferences “Protein Phosphatases”, Steamboat Springs,
Colorado (USA), July 18-23, 2010.
Page 11 / 14
12. *Labbé, D.; *Lessard, L.; Deblois, G.; Filion, M.; Giguère, V.; Tremblay, ML. Androgen-dependent
regulation of PTP1B expression and activity. Poster presented at the FASEB Summer Research
Conferences “Protein Phosphatases”, Steamboat Springs, Colorado (USA), July 18-23, 2010.
13. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;
Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotes
tumorigenesis in prostate cancer. Poster presented at the 9th Conference on Signaling in Normal and
Cancer Cells, Banff (Alberta), March 6-10, 2011.
14. Tremblay, ML.; *Labbé, D.; *Lessard, L.; Bégin, LR.; Filion, M.; Leloy, A.; Filion, M.; Saad, F.; MesMasson, A-M. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells.
Poster presented at the Innovative Minds in Prostate Cancer Today (IMPaCT) Conference, Orlando,
Florida (USA), March 9-12, 2011.
15. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.;
Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotes
tumorigenesis in prostate cancer. Poster presented at the Montréal International Symposium on
Angiogenesis and Metastasis (MISAM 2011), Montréal (Québec), June 15-17, 2011.
16. Hardy, S.; Wong, NN.; Labbé, D.; Aubry, I.; Lessard, L.; Bégin, LR.; Saad, F.; Mes-Masson, A-M.;
Kerr, R.; Tremblay, ML. Regulation of phosphatase of regenerating liver-2 (PRL-2) in cancer. Poster
presented at the Europhosphatase 2011 (EMBO Conference Series); Protein Phosphatases: From
Molecules to Networks, Vienna, Austria, July 18-23, 2011.
Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase that
promotes the progression of prostate cancer. Poster presented at the PTEN Pathways & Targets, Cold
Spring Harbor, New York (USA), March 13-16, 2012.
18. Deblois, G.; Labbé, D.; Caron, M.; Bourque, G.; Tremblay, ML.; Giguère, V. Growth factor
signaling in breast cancer cells induces a shift in the transcriptional program of ERR-alpha? Poster
presented at the Nuclear Receptor Matrix: Reloaded (Keystone Symposia), Whistler (British
Columbia), April 19-24, 2012.
19. Deblois, G.; Labbé, D.; Caron, M.; Bourque, G.; Tremblay, ML.; Giguère, V. Growth factor
signaling in breast cancer cells induces a shift in the transcriptional program of ERR-alpha? Poster
presented at The Terry Fox Research Institute, 3rd annual Scientific Meeting, Victoria (British
Columbia), May 10-12, 2012.
Page 12 / 14
20. Labbé, DP.; Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mes-Masson, A-M.; Saad, F.; Trotman,
LC.; Giguère, V.; Tremblay, ML. La région chromosomique 20q13 est régulée par le récepteur aux
androgènes et amplifiée dans les cancer aggressifs de la prostate : Focus sur le rôle de PTP1B. Poster
presented at the Signalisation Québec 2012, Bécancour (Québec), June 13-15, 2012.
21. Labbé, DP.; Lessard, L.; Uetani, N.; Bégin, LR.; Haigh, JJ.; Paquet, M.; Trotman, LC.; Tremblay,
ML. PTP1B deficiency potentiate prostate cancer aggressiveness induced by PTEN-loss upon high fat
diet. Poster presented at Annual Research Conference on Food, Nutrition, Physical Activity and
Cancer of the American Institute for Cancer Research (AICR), Bethesda, Maryland (USA), November
7-8, 2013.
22. Labbé, DP.; Nowak, DG.; Deblois, G.; Lessard, L.; Giguère, V.; *Trotman, LC.; *Tremblay, ML.
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is androgen receptor-regulated
and amplified in metastatic tumors. Poster presented at the American Association for Cancer
Research (AACR) – Prostate Cancer Fondation Conference on Advances in Prostate Cancer Research,
San Diego, California (USA), January 18-21, 2014.
*Co-corresponding authors
23. Coulis, G.; Shi, Y.; Yang, M.; Labbé, DP.; Karsenty, G.; Tonks, NK.; Tremblay, ML.; Tardif, JC.;
Boivin, B. Caractérisation de la voie ROS-PTP1B-AGO2 dans l'hypertrophie cardiaque. Poster
presented at the 56ème réunion annuelle du Club de Recherches Cliniques du Québec (CRCQ), SteAdèle (Québec), September 18-20, 2014.
24. Coulis, G.; Shi, Y.; Yang, M.; Labbé, DP.; Karsenty, G.; Tonks, NK.; Tremblay, ML.; Tardif, JC.;
Boivin, B. Protein Tyrosine Phosphatase 1B regulation of Argonaute 2 in cardiac hypertrophy. Poster
presented at the 1st Cardiovascular Redox Signaling Symposium, Milwaukee, Wisconsin (USA),
November 14th, 2014.
25. Ebot, EM.; Gerke, T.; Tyekucheva S.; Labbé, DP.; Zadra, G.; Kelly, RS.; Bowden, M.; Rider, JR.;
Wilson, KM.; Martin, NE.; Brown, M.; Vander Heiden, MG.; Giovannucci, EL.; Loda, M.; Mucci, LA.
Identifying obesity-linked gene expression changes in prostate cancer. Poster presented at the 8th
Annual Multi-Institutional Prostate Cancer Program Retreat (Sponsored by DF/HCC, FHCRC, JHMI,
MSKCC and UMCCC), Fort Lauderdale, Florida (USA), March 15-17, 2015.
26. Ebot, EM.; Gerke, T.; Tyekucheva S.; Labbé, DP.; Zadra, G.; Kelly, RS.; Bowden, M.; Rider, JR.;
Wilson, KM.; Martin, NE.; Brown, M.; Vander Heiden, MG.; Giovannucci, EL.; Loda, M.; Mucci, LA.
Identifying obesity-linked gene expression changes in prostate cancer. Poster presented at the AACR
Annual Meeting 2015, Philadelphia, Pennsylvania (USA), April 18-22, 2015.
27. Labbé, DP.; Uetani, N.; Vinette, V.; Aubry, I.; Migon, E.; Sirois, J.; Haigh, JJ.; Lessard, L.; Bégin,
LR.; Trotman, LC.; Paquet, M.; Tremblay, ML. PTP1B deficiency potentiate prostate cancer
invasiveness by sensitizing Pten-null tumors to high fat diet. Poster presented at the AACR
Metabolism and Cancer, Bellevue, Washington (USA), June 7-10, 2015.
Page 13 / 14
28. Ebot, EM.; Gerke, T.; Labbé, DP.; Sinnott, J.; Zadra, G.; Rider, JR.; Tyekucheva, S.; Wilson, KM.;
Kelly, RS.; Penney, KL.; Loda, M.; Kantoff, P.; Finn, S.; Vander Heiden, MG.; Giovannucci, EL.;
Brown, M.; Mucci, LA. Identifying obesity-linked gene expression changes in prostate cancer. Poster
presented at the AACR Metabolism and Cancer, Bellevue, Washington (USA), June 7-10, 2015.
Jaffe, JD.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Loda, M.; Brown, M. High fat diet enhances MYCdriven prostate cancer through epigenomic and metabolomics rewiring. Poster presented at the
AACR Chromatin and Epigenetics in Cancer, Atlanta, Georgia (USA), September 24-27 2015.
30. *Labbé, DP.; *Zadra, G.; Yang, M.; Lin, CY.; Reyes, JM.; Cacciatore, S.; Ebot, EM.; Cotter, M.;
Syamala, S.; Creech, AL.; Jaffe, JD.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Chavarro, JE.; ★Loda, M.;
★
Brown, M. High fat diet enhances MYC-driven prostate cancer through epigenomic and
metabolomics rewiring. Poster presented at the Broad Institute Eleventh Annual Retreat, Boston,
Massachusetts (USA), December 14-15 2015.
*Contributed equally to the work; ★Co-corresponding authors
AFFILIATIONS
Institute of Food Technologists (USA)
Canadian Institute of Food Science and Technology
Association of scientific communicators of Québec
Alumni association, Université Laval
American Association for the Advancement of Science (AAAS)
American Association for Cancer Research (AACR)
20032003-2014
2005200620122013-
EXTRACURRICULAR INVOLVEMENT
Representative
• Linking commitee with the “Ordre des agronomes du Québec”
2003-2004
• Faculty council of the Faculty of Agricultural Sciences and Food, Université Laval
2004
• Academic council of the Faculty of Sciences, Université du Québec à Montréal
2008
Food Science student association
• Organizer of the “Food Science wine and cheese”
2003
• President of organizing comittee for first year welcoming events (Food Science)
2003
e
• President of the organizing comitee “15 Colloque STA” (more than 160 food
2003
science professionals participate at this meeting).
• President and VP of the external affairs
2003-2006
Volunteer
• Mathematics tutor
2001
• Salon de l’agriculture, de l’alimentation et de la consommation (SAAC)
2003, 04, 06
• Défi Canderel
2009, 10, 12
Page 14 / 14
MEDIA APPEARANCE / INTERVIEWS
1. Labbé, DP. Interview with Guy Simard at “Que le Québec se lève”. Cogeco Diffusion (98.5 FM),
March 7th 2015.
2. Labbé, DP. Interview on “Diet, Epigenetics and Prostate Cancer“ for Prostatepedia, Volume 1 (5)
January 2016.
3. Labbé, DP. Interview for “Science ou Fiction“, Season 6, Episode 8 “Aliments miracles”. Point
Virgule Communication; shooting on October 21st 2015, broadcast scheduled in Spring 2016 on the
French Channel TV5.
REFERENCES
Michel L. Tremblay, Ph.D.
Professor
Rosalind and Morris Goodman Cancer Centre
McGill University
1160, Pine Ave. West, Room 602
Montréal, Québec, H3A 1A3
E-Mail: [email protected]
Phone: (514) 398-7290
Relationship: Ph.D. supervisor
Myles A. Brown, M.D.
Professor
Dana-Farber Cancer Institute
Harvard Medical School
450, Brookline Ave., Dana 730
Boston, Massachusett, 02215
Phone: (617) 632-3948
Relationship: Postdoc supervisor
Lorelei A. Mucci, M.P.H., Sc.D.
Associate Professor
Harvard T.H. Chan School of Public Health
677, Huntington Avenue, Kresge 920e
Boston, Massachussett, 02215
Phone: (617) 432-1732
Relationship: Collaborator
Claudia Steele, assistant
Phone: (617) 582-7646

CV (David P Labbé) 21-01-2016 - Association des communicateurs

Transcription

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