alberto bianco - curriculum vitae

Transcription

ALBERTO BIANCO - CURRICULUM VITAE
I.
PERSONAL DATA
Place of birth:
Date of birth:
Citizenship:
Marital Status:
II.
Pieve di Soligo, Treviso, Italy
February 5, 1967
Italian
Married (one child)
ACADEMIC DEGREE
March 1992
“Laurea” in Chemistry
Overall mark: 110/110 cum laude
Dipartimento di Chimica Organica, University of Padova, Italy
Thesis: Peptide Helices as Molecular Spacers
Supervisor: Prof. Claudio Toniolo
May 1992
Qualification for Chemistry Profession
December 1995
Doctorate in Chemistry
Thesis: Peptide Helices as Fullerene-Receptors and Fullerene-Peptides
Supervisor: Prof. Claudio Toniolo
February 2003
Habilitation à Diriger les Recherches (HDR)
Louis Pasteur University, Strasbourg, France
III.
RESEARCH EXPERIENCE
June 1992 - January 1993
Institut de Chimie Organique, Université de Lausanne, Suisse
Post-“Laurea” stage
Research group leader: Prof. Manfred Mutter
April 1996 - September 1997
Institut für Organische Chemie, Universität Tübingen, Germany
Post-doctoral fellow
Research group leader: Prof. Günther Jung
October 1997 - September 1998
Research group leader: Prof. Gianfranco Scorrano
November 1998 - September 2001
Institut de Biologie Moléculaire et Cellulaire, UPR 9021 CNRS
Immunologie et chimie thérapeutiques, Strasbourg, France
Research group leader: Dr. Jean-Paul Briand
October 2001- September 2006
Research Associate at CNRS (CR1)
IV.
CURRENT POSITION
October 2006- to date
Research Director at CNRS (DR2)
V.
AWARDS AND GRANTS
April 1991
EniChem award for Chemistry Students
June 1992 - January 1993
Fellowship from Fond National Suisse
April 1996 - September 1997
EPS-Exchange Grant sponsored by Debiopharm
Fellowship from Alexander von Humboldt Foundation
Fellowship from Aldo Gini Foundation
October 1997 - September 1998
Fellowship from University of Padova
November 1998 - December 1999
Fellowship from Industry
January 2000 – September 2001
Fellowship from Sidaction
April 2004
Journals Grants for International Authors from the Royal Society of Chemistry
March 2007
Nominee of the 2006 Descartes Prize for Scientific Collaborative Research
November 2010
Journals Grants for International Authors from the Royal Society of Chemistry
VI.
EDITORIAL ACTIVITY AND MEMBERSHIP
- Editor of Carbon (2011 to date)
- Member of the Editorial Advisory Board of the Journal of Peptide Science (2009 to date)
- Member of the Editorial Advisory Board of Nanomedicine (2011 to date)
- Member of the Editorial Advisory Board and then Associate Editor of Journal of Biomedical
Nanotechnology (2005-2007)
- Guest Editor of the Special Issue of the Journal of Peptide Science: “Peptides in Nanotechnology”
2008, 14, 117
- Guest Editor of the Special Issue of the Journal of Peptide Science: “Peptide-based materials: from
nanostructures to applications” 2011, 17, 73
- Member of the French Group of Peptides and Proteins (GFPP)
- Member of the European Peptide Society
- Member of the American Chemical Society
- Member of the Committee of Experts of the AFSSET
LIST OF PUBLICATIONS
1.
Crisma, M.; Valle, G.; Formaggio, F.; Bianco, A.; Toniolo, C. “Helical Screw Sense of Peptide
Molecules. X-Ray Diffraction Structures of Two Oligopeptides with a Single Chiral Center”
Journal of the Chemical Society, Perkin Transaction 2 1993, 987-991.
2.
Prato, M.; Bianco, A.; Maggini, M.; Scorrano, G.; Toniolo, C.; Wudl, F. “Synthesis and
Characterization of the First Fullerene-Peptide”
Journal of Organic Chemistry 1993, 58, 5578-5580.
3.
Maggini, M.; Scorrano, G.; Bianco, A.; Toniolo, C.; Sijbesma, R. P.; Wudl, F.; Prato, M. “Addition
Reactions of C60 Leading to Fulleroprolines”
Journal of the Chemical Society, Chemical Communications 1994, 305-306.
4.
Toniolo, C.; Bianco, A.; Maggini, M.; Scorrano, G.; Prato, M.; Marastoni, M.; Tomatis, R.; Spisani,
S.; Palù, G.; Blair, E. P. “A Bioactive Fullerene-Peptide”
Journal of Medicinal Chemistry 1994, 37, 4558-4562.
5.
Maggini, M.; Scorrano, G.; Bianco, A.; Toniolo, C.; Prato, M. “Synthesis and Characterization of
Both Enantiomers of a Chiral C60 Derivative with C2 Symmetry”
Tetrahedron Letters 1995, 36, 2845-2846.
6.
Toniolo, C.; Bianco, A.; Formaggio, F.; Crisma, M.; Bonora, G. M.; Benedetti, E.; Del Duca, V.;
Saviano, M.; Di Blasio, B.; Pedone, C.; Aubry, A. “The Polypeptide 310-Helix as a Template for
Molecular Recognition Studies. Structural Characterization of a Side-chain Functionalized
Octapeptide”
Bioorganic and Medicinal Chemistry 1995, 3, 1211-1221.
7.
Crisma, M.; Bianco, A.; Formaggio, F.; Toniolo, C.; Kamphuis, J. “The Polypeptide 310-Helix as a
Template and a Spacer”
Letters in Peptide Science 1995, 2, 187-189.
8.
Flippen-Anderson, J. L.; George, C.; Valle, G.; Valente, E.; Bianco, A.; Formaggio, F.; Crisma,
M.; Toniolo, C. “Crystallographic characterization of geometry and conformation of TOAC, a
nitroxide spin-labelled Cα,α-disubstituted glycine, in simple derivatives and model peptides”
International Journal of Peptide and Protein Research 1996, 47, 231-238.
9.
Bianco, A.; Maggini, M.; Scorrano, G.; Toniolo, C.; Marconi G.; Villani C.; Prato, M. “Synthesis,
Chiroptical Properties and Configurational Assignment of Fulleroproline Derivatives and Peptides”
Journal of the American Chemical Society 1996, 118, 4072-4080.
10. Novello, F.; Prato, M.; Da Ros, T.; De Amici, M.; Bianco, A.; Toniolo, C.; Maggini, M.
“Stereoselective additions to 60[fullerene]”
Chemical Communications 1996, 903-904.
11. Crisma, M.; Valle, G.; Bianco, A.; Formaggio, F.; Toniolo, C. “Crystal Structure of NBenzyloxycarbonyl-L-alanyl-α-aminoisobutyric acid tert-butyl ester, C19H28N2O5”
Zeitschrift für Kristallographie 1996, 211, 561-562.
12. George, C.; Flippen-Anderson, J. L.; Bianco, A.; Crisma, M.; Formaggio, F.; Toniolo, C.
“Crystallographic Characterization of Tryptophan-Containing Peptide 310-Helices”
Peptide Research 1996, 9, 315-321.
13. Crisma, M.; Valle, G.; Bianco, A.; Formaggio, F.; Toniolo, C. “Conformational characteristics of
the -Pro-Ala- dipeptide sequence”
Zeitschrift für Kristallographie 1997, 212, 465-471.
14. Bianco, A.; Bertolini, T.; Crisma, M.; Valle, G.; Toniolo, C.; Maggini, M.; Scorrano, G.; Prato, M.
“β-Turn induction by C60-based fulleroproline. Synthesis and conformational characterization of
Fpr/Pro small peptides”
Journal of Peptide Research 1997, 50, 159-170.
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15. Bianco, A.; Gasparrini, F.; Maggini, M.; Misiti, D.; Polese, A.; Prato, M.; Scorrano, G.; Toniolo, C.;
Villani, C. “Molecular Recognition by a Silica-Bound Fullerene Derivative”
16. Guldi, D. M.; Maggini, M.; Scorrano, G.; Prato, M.; Bianco, A.; Toniolo, C. “Photoinduced Electron
Transfer in Supramolecular Fullerene/Ferrocene Systems”
Journal of Information Recording 1998, 24, 33-39.
17. Bianco, A.; Lucchini, V.; Maggini, M.; Prato, M.; Scorrano, G.; Toniolo, C. “Trans-Cis Amide Bond
Isomerization in Fulleroprolines”
Journal of Peptide Science 1998, 4, 364-368.
18. Bianco, A.; Zabel, C.; Walden, P.; Jung, G. “N-Hydroxy Amide Analogues of MHC-Class I Peptide
Ligands with Nanomolar Binding Affinities”
19. Bianco, A.; Brock, C.; Zabel, C.; Walk, T.; Walden, P.; Jung, G. “New synthetic non-peptide
ligands for classical MHC class I molecules”
Journal of Biological Chemistry 1998, 273, 28759-28765.
20. Wolf, W. M.; Stasiak, M.; Leplawy, M. T.; Bianco, A.; Formaggio, F.; Crisma, M.; Toniolo, C.
“Destabilization of the 310-Helix in Peptides Based on Cα-Tetrasubstituted α-Amino Acids by MainChain to Side-Chain Hydrogen Bonds”
21. Polese, A.; Mondini, S.; Bianco, A.; Toniolo, C.; Scorrano, G.; Guldi, D. M.; Maggini, M. “Solvent2+
Dependent Intramolecular Electron Transfer in a Peptide-Linked [Ru(bpy)3] -C60 Dyad”
22. Hin, S.; Zabel, C.; Bianco, A.; Jung G.; Walden P. “Cutting Edge: N-Hydroxy Peptides: A New
Class of T Cell Receptor Antagonists”
Journal of Immunology 1999, 163, 2363-2367.
23. Bianco, A.; Kaiser, D.; Jung, G. “N-Hydroxy Peptides as Substrates for α-Chymotrypsin”
Journal of Peptide Research 1999, 54, 544-548.
24. Nisole, S.; Krust, B.; Dam, E.; Bianco, A.; Seddiki, N.; Loaec, S.; Callebaut, C.; Guichard, G.;
Muller, S.; Briand, J.-P.; Hovanessian, A. G. “The HB-19 Pseudopeptide 5[Kψ(CH2N)PR]-TASP
Inhibits Attachment of T-Lymphocyte and Macrophage-Tropic HIV to Permissive Cells”
AIDS Research and Human Retroviruses 2000, 16, 237-249.
25. Bianco, A.; Sonksen, C. P.; Roepstorff, P.; Briand, J.-P. “Solid-Phase Synthesis and Structural
Characterization of Highly Substituted Hydroxyproline-Based 2,5-Diketopiperazines”
26. Bianco, A.; Furrer, J.; Limal, D.; Guichard, G.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.-P.
“Multi-Step Synthesis of 2,5-Diketopiperazines on Different Solid Supports Monitored by High
Resolution Magic Angle Spinning NMR Spectroscopy”
Journal of Combinatorial Chemistry 2000, 2, 681-690.
27. Bianco, A.; Da Ros, T.; Prato, M.; Toniolo, C. “Fullerene-based amino acid and peptides”
28. Piotto, M.; Bourdonneau, M.; Furrer, J.; Raya, J.; Bianco, A.; Elbayed, K. “Destruction of
Magnetization During TOCSY Experiments Performed Under Magic Angle Spinning: Effect of
Radial B1 Inhomogeneities”
Journal of Magnetic Resonance 2001, 149, 114-118.
29. Joseph, C.; Stier, G.; O’Brien, R.; Politou A.; Atkinson, R. A.; Bianco, A.; Ladbury, J. E.; Martin,
S.; Pastore, A. “A structural characterization of the interaction between titin Z repeats and αactinin C-terminal domain”
Biochemistry 2001, 40, 4957-4965.
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30. Furrer, J.; Piotto, M.; Bourdonneau, M.; Limal, D.; Guichard, G.; Elbayed, K.; Raya, J.; Briand, J.P.; Bianco, A. “Evidence of Secondary Structure by High Resolution Magic Angle Spinning NMR
Spectroscopy of a Bioactive Peptide Bound to Different Solid Supports”
31. Choppin, J.; Cohen, W.; Bianco, A.; Connan, F.; Dalod, M.; Briand, J.-P.; Guillet, G. “Characters
of HIV-regions containing multiple HLA-restricted cytotoxic T cell epitopes: richness in HLAbinding motifs and sensitivity to proteasome”
32. Hin, S.; Bianco, A.; Zabel, C.; Jung, G.; Walden, P. “Mimetics of a T cell epitope based on polyN-acylated amine backbone structures induce T cells in vitro and in vivo”
33. Furrer, J.; Elbayed, K.; Bourdonneau, M.; Raya, J.; Limal, D.; Bianco, A.; Piotto, M. “Dynamic and
magnetic susceptibility effects on the MAS NMR linewidth of a tetrapeptide bound to different
resins”
Magnetic Resonance in Chemistry 2002, 40, 123-132.
34. Bianco, A.; Corvaja, C.; Crisma, M.; Guldi, D. M.; Maggini, M.; Sartori, E.; Toniolo, C. “A Helical
Peptide Receptor for [60]Fullerene”
Chemistry: a European Journal 2002, 8, 1544-1553.
35. Nisole, S.; Said, E. A.; Mische, C.; Prevost M.-C.; Krust, B.; Bouvet, P.; Bianco, A.; Briand, J.-P.;
Hovanessian, A. G. “The Anti-HIV Pentameric Pseudopeptide HB-19 Binds the C-terminal End of
Nucleolin and Prevents Anchorage of Virus Particles on Target Cells”
36. Raya, J.; Bianco, A.; Furrer, J.; Briand, J.-P.; Piotto, M.; Elbayed, K. “Proton dipolar recoupling in
resin-bound peptides under high resolution magic angle spinning”
Journal of Magnetic Resonance 2002, 157, 43-51.
37. Cohen, W. M.; Bianco, A.; Connan, F.; Camoin, L.; Dalod, M.; Lauvau, G.; Ferriès, E.; CulmannPenciolelli, B.; van Endert, P. M.; Briand, J. P.; Choppin, J.; Guillet, J. G. “Study of AntigenProcessing Steps Reveals Preferences Explaining Differential Biological Outcomes of Two HLAA2-Restricted Immunodominant Epitopes from Human Immunodeficiency Virus Type 1”
Journal of Virology 2002, 76, 10219-10225.
38. Pantarotto, D.; Bianco, A.; Pellarini, F.; Tossi, A.; Giangaspero, A.; Zelezetsky, I.; Briand, J. P.;
Prato M. “Solid-Phase Synthesis of Fullerene-Peptides”
39. Georgakilas, V.; Tagmatarchis, N.; Pantarotto, D.; Bianco, A.; Briand, J.-P.; Prato M. “Amino acid
functionalisation of water soluble carbon nanotubes”
40. Lancelot, N.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.-P.; Formaggio, F.; Toniolo, C.; Bianco, A.
“Characterization of the 310-Helix in Model Peptides by HRMAS NMR Spectroscopy”
41. Pantarotto, D.; Hoebeke, J.; Graff, R.; Partidos, C. D.; Briand, J.-P.; Prato, M.; Bianco, A.
“Synthesis, Structural Characterization and Immunological Properties of Carbon Nanotubes
Functionalized with Peptides”
42. Rainaldi, M.; Lancelot, N.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.-P.; Kaptein, B.; Broxterman,
Q. B.; Berkessel, A.; Formaggio, F.; Toniolo, C.; Bianco, A. “Conformational analysis by HRMAS
NMR spectroscopy of resin-bound homo-peptides from Cα-methyl-leucine”
Organic and Biomolecular Chemistry 2003, 1, 1835-1837.
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43. Poschalko, A.; Rohr, T.; Gruber, H.; Bianco, A.; Guichard, G.; Briand, J.-P.; Weber, V.;
Falkenhagen, D. “SUBPOL: A Novel Sucrose-based Polymer Support for Solid-Phase Peptide
Synthesis and Affinity Chromatography Applications”
44. Pantarotto, D.; Partidos, C. D.; Hoebeke, J.; Brown, F.; Kramer, E.; Briand, J.-P.; Muller, S.; Prato,
M.; Bianco, A. “Immunization with peptide-functionalized carbon nanotubes enhances virusspecific neutralizing antibody responses”
Chemistry and Biology 2003, 10, 961-966.
45. Bianco, A.; Prato, M. “Can carbon nanotubes be considered useful tools for biological
applications?”
Advanced Materials 2003, 15, 1765-1768.
46. Bianco, A.; Pantarotto, D.; Hoebeke, J.; Briand, J.-P.; Prato, M.; “Solid-phase synthesis and
characterization of a novel fullerene-peptide derived from histone H3”
47. Pantarotto, D.; Briand, J.-P.; Prato, M.; Bianco, A. “Translocation of Bioactive Peptides Across
Cell Membranes by Carbon Nanotubes”
48. Pantarotto, D.; Tagmatarchis, N.; Bianco, A.; Prato, M. “Synthesis and Biological Properties of
Fullerene-containing Amino Acids and Peptides”
MiniReviews in Medicinal Chemistry 2004, 4, 805-814.
49. Lancelot, N.; Elbayed, K.; Bianco, A.; Piotto, M. “Measurement of scaled residual dipolar
couplings in proteins using variable-angle sample spinning”
Journal of Biomolecular NMR 2004, 29, 259-269.
50. Poschalko, A.; Lancelot, N.; Marin, J.; Larras, V.; Limal, D.; Elbayed, K.; Raya, J.; Piotto, M.; Briand,
J.-P.; Guichard, G.; Bianco, A. “DEUSS: a Perdeuterated Polyoxyethylene-based Resin for
Improving HRMAS NMR Study of Solid-supported Molecules”
51. Pantarotto, D.; Singh, R.; McCarthy, D.; Erhardt, M.; Briand, J.P.; Prato, M.; Kostarelos, K.;
Bianco, A. “Functionalised carbon nanotubes for plasmid DNA gene delivery” Angewandte
Chemie International Edition 2004, 43, 5242-5246. Angewandte Chemie 2004, 116, 5354-5358.
52. Bianco, A. “Carbon Nanotubes for the Delivery of Therapeutic Molecules”
Expert Opinion on Drug Delivery 2004, 1, 57-65.
53. Bianco, A.; Kostarelos, K.; Partidos, C. D.; Prato, M. “Biomedical applications of functionalised
carbon nanotubes”
54. Bianco, A.; Hoebeke, J.; Godefroy, S.; Chaloin, O.; Pantarotto, D.; Briand, J.-P.; Muller, S.; Prato,
M.; Partidos, C. D. “Cationic Carbon Nanotubes Bind to CpG Oligodeoxynucleotides and Enhance
Their Immunostimulatory Properties”
55. Kostarelos, K.; Lacerda, L.; Partidos, C. D.; Prato, M.; Bianco, A. “Carbon Nanotube-mediated
Delivery of Peptides and Genes to Cells: Translating Nanobiotechnology to Therapeutics”
Journal of Drug Delivery Science and Technology 2005, 15, 41-47.
56. Bianco, A.; Hoebeke, J.; Kostarelos, K.; Prato, M.; Partidos, C. D. “Carbon nanotubes: on the
road to deliver”
Current Drug Delivery 2005, 2, 253-259.
57. Singh, R.; Pantarotto, D.; McCarthy, D.; Chaloin, O.; Hoebeke, J.; Partidos, C. D.; Briand, J.-P.;
Prato, M.; Bianco, A.; Kostarelos, K. “Binding and condensation of plasmid DNA onto
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functionalized carbon nanotubes: towards the construction of nanotube-based gene delivery
vectors”
58. Pastorin, G.; Kostarelos, K.; Prato, M.; Bianco, A. “Functionalized Carbon Nanotubes: Towards
the Delivery of Therapeutic Molecules”
Journal of Biomedical Nanotechnology 2005, 1, 133-142.
59. Bianco, A. “Efficient solid-phase synthesis of fullero-peptides using Merrifield strategy” Chemical
Communications 2005, 3174-3176.
60. Wu, W.; Wieckowski, S.; Pastorin, G.; Benincasa, M.; Klumpp, C.; Briand, J.-P.; Gennaro, R.;
Prato, M.; Bianco, A. “Targeted Delivery of Amphotericin B to Cells Using Functionalized Carbon
Nanotubes”
Angewandte Chemie International Edition 2005, 44, 6358-6362. Angewandte Chemie 2005, 117,
6516-6520.
61. Bianco, A.; Kostarelos, K.; Prato, M. “Applications of Carbon Nanotubes in Drug Delivery“
Current Opinion in Chemical Biology 2005, 9, 674-679.
62. Fournel, S.; Wieckowski, S.; Sun, W.; Trouche, N.; Dumortier, H.; Bianco, A.; Chaloin, O.; Habib,
M.; Peter, J.-C.; Schneider, P.; Vray, B.; Toes, R. E.; Offringa, R.; Melief, C. J.; Hoebeke, J.;
Guichard, G. “C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L”
Nature Chemical Biology 2005, 1, 377-382.
63. Tasis, D.; Tagmatarchis, N.; Bianco, A.; Prato M. “Chemistry of Carbon Nanotubes”
Chemical Review 2006, 106, 1105-1136.
64. Klumpp, C.; Kostarelos, K.; Prato M.; Bianco, A. “Functionalized Carbon Nanotubes as Alternative
Non-viral Vectors”
Biochimica and Biophysica Acta 2006, 1758, 404-412.
65. Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin G.; Klumpp, C.; Prato, M.; Bianco, A.; Kostarelos,
K. “Tissue Biodistribution and Blood Clearance Rates of Intravenously Administered Carbon
Nanotube Radiotracers”
Proceedings of the National Academy of Science, USA 2006, 103, 3357-3362.
66. Campidelli, S.; Klumpp, C.; Bianco, A.; Guldi, D. M.; Prato, M. “Functionalization of CNT:
Synthesis and Applications in Photovoltaics and Biology”
Journal of Physical Organic Chemistry 2006, 19, 531-539.
67. Lacerda, L.; Pastorin, G.; Wu, W.; Prato, M.; Bianco, A.; Kostarelos, K. “Functionalised carbon
nanotube autofluorescence as a tool to monitor bundle formation and dissociation in aqueous
phases by fluorescence spectrophotometry: the effect of plasmid DNA complexation”
Advanced Functional Materials 2006, 16, 1839-1846.
68. Brough, P.; Klumpp, C.; Bianco, A.; Campidelli, S.; Prato, M. “[60]Fullerene−Pyrrolidinoe-Noxides”
69. Pastorin, G.; Wu, W.; Wieckowski, S.; Kostarelos, K.; Briand, J.-P.; Prato, M.; Bianco, A. “Double
functionalisation of carbon nanotubes for multimodal drug delivery”
70. Bianco, A.; Fournel, S.; Wieckowski, S.; Hoebeke, J.; Guichard G. “Solid-phase synthesis of
CD40L mimetics”
71. Bianco, A.; Nogarole, M.; Maggini, M.; Scorrano, G. “Hydrolysis rate of functionalized fullerenes
bearing alkoxysilanes: a comparative study”
European Journal of Organic Chemistry 2006, 2934-2941.
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72. Pastorin, G.; Marchesan, S.; Hoebeke, J.; Da Ros, T.; Ehret-Sabatier, L.; Briand, J.-P.; Prato, M.;
Bianco, A. “Design and Activity of Cationic Fulleropyrrolidines as Inhibitors of
Acetylcholinesterase”
73. Dumortier, H.; Lacotte, S.; Pastorin, G.; Marega, R.; Wu, W.; Bonifazi, D.; Briand, J.-P.; Muller, S.;
Prato, M.; Bianco, A. “Functionalized Carbon Nanotubes are Nontoxic for the Immune System
Regulatory Cells”
Nano Letters 2006, 6, 1522-1528.
74. Hauquier, F.; Pastorin, G.; Hapiot, P.; Prato, M.; Bianco A.; Fabre, B.; “Carbon nanotubefunctionaliozed silicon surfaces with an efficient redox communication”
75. Lacerda, L.; Bianco, A.; Prato, M.; Kostarelos, K. “Carbon Nanotubes as Nanomedicines: from
Toxicology to Pharmacology”
Advanced Drug Delivery Reviews 2006, 58, 1460-1470.
76. Kostarelos, K.; Lacerda, L.; Pastorin, G.; Wu, W.; Wieckowski, S.; Luangsivilay, J.; Godefroy, S.;
Pantarotto, D.; Briand, J.-P.; Muller, S.; Prato, M.; Bianco, A. “Functionalised Carbon Nanotube
Cellular Uptake and Internalisation Mechanism is Independent of Functional Group and Cell Type”
Nature Nanotechnology 2007, 2, 108-113.
77. Lacerda, L.; Pastorin, G.; Gathercole, D.; Prato, M.; Bianco, A.; Kostarelos, K.
Trafficking of Carbon Nanotubes by Confocal Laser Scanning Microscopy”
“
Intracellular
78. Habib, M.; Rivas, M. N.; Chamekh, M.; Wieckowski, S.; Sun, W.; Bianco, A.; Trouche, Chaloin,
O.; N.; Dumortier, H.; Goldman, M.; Guichard, G.; Fournel.; Vray, B. “Cutting Edge: Small
+
Molecule CD40 Ligand Mimetics Promote Control of Parasitemia and Enhance CD8 T Cell
Producing Interferon- during Experimental Trypanosoma Cruzi Infection”
79. Klumpp, C.; Lacerda, L.; Chaloin, O.; Da Ros, T.; Kostarelos, K.; Prato, M.; Bianco, A.
”Multifunctionalised cationic fullerene adducts for gene transfer: design, synthesis and DNA
complexation”
80. Lacerda, L.; Raffa, S.; Prato, M.; Bianco, A.; Kostarelos, K. “Cell-Penetrating Carbon Nanotubes
in the Delivery of Therapeutics”
Nano Today 2007, 2, 38-43.
81. Prato, M.; Kostarelos, K.; Bianco, A. “Functionalized Carbon Nanotubes in Drug Design and
Discovery”
Account of Chemical Research 2008, 41, 60-68.
82. Lacerda, L.; Bianco, A.; Prato, M.; Kostarelos, K. “Carbon nanotube cell translocation and delivery
of nucleic acids in vitro and in vivo”
Journal of Material Chemistry 2008, 18, 17-22.
83. Lacerda, L.; Soundararajan, A.; Singh, R.; Pastorin, G.; Al-Jamal, K. T.; Turton, J.; Frederik, P.;
Herrero, M. A.; Li, S.; Bao, A.; Emfietzoglou, D.; Mather; S.; Phillips, W. T.; Prato, M.; Bianco, A.;
Goins, B.; Kostarelos, K. “Dynamic Imaging of Functionalised Multi-Walled Carbon Nanotube
Systemic Circulation and Urinary Excretion”
84. Lacotte, S.; García, A.; Décossas, M.; Al-Jamal, W. T.; Li, S.; Kostarelos, K.; Muller, S.; Prato, M.;
Dumortier, H.; Bianco, A. “Interfacing functionalized carbon nanohorns with primary phagocytic
cells”
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85. Ali-Boucetta, H.; Al-Jamal, K. T.; McCarthy, D.; Prato, M.; Bianco, A.; Kostarelos, K. “Multiwalled
carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics”
86. Bianco, A.; Kostarelos, K.; Prato, M. “Opportunities and challenges of carbon-based
nanomaterials for cancer therapy”
Expert Opinion on Drug Delivery 2008, 5, 331-342.
87. Violette, A.; Lancelot, N.; Poschalko, A.; Piotto, M.; Briand, J.-P.; Raya, J.; Elbayed, K.; Bianco,
A.; Guichard G. “Exploring helical folding of oligoureas during chain elongation by HRMAS NMR”
88. Lacerda, L.; Ali-Boucetta, H.; Herrero, M. A.; Pastorin, G.; Bianco, A.; Prato, M.; Kostarelos, K.
“Tissue histology and physiology following intravenous administration of different types of
functionalized multiwalled carbon nanotubes”
Nanomedicine 2008, 3, 149-161.
89. Fabre, B.; Hauquier, F.; Herrrier, C.; Pastorin, G.; Wu. W.; Bianco, A.; Prato, M.; Hapiot P.;
Zigah, D.; Prasciolu, M.; Vaccari, L. “Covalent assembly and micropatterning of multiwalled
carbon nanotubes to monolayer-modified Si(111) surfaces”
Langmuir 2008, 24, 6595-6602.
90. Li, S.; Wu, W.; Campidelli, S.; Prato, M.; Sarnatskaïa, V.; Tridon, A.; Nikolaev, A.; Nikolaev, V.;
Bianco, A.; Snezhkova, E. “Adsorption of carbon nanotubes on active carbon microparticles”
Carbon 2008, 46, 1091-1095.
91. Lacerda, L.; Herrero, M. A.; Venner, K.; Bianco, A.; Prato, M.; Kostarelos, K. “Carbon-Nanotube
Shape and Individualization Critical for Renal Excretion”
Small 2008, 4, 1130-1132.
92. Geotti-Bianchini, P.; Beyrath, J.; Chaloin, O.; Formaggio, F.; Bianco, A. “Design and Synthesis of
Intrinsically Cell-Penetrating Nucleopeptides”
93. Yandar, N.; Pastorin G.; Prato, M.; Bianco, A.; Patarroyo, M. E.; Lozano, J. M. “Immunological
profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an
infected Plasmodium berghei mouse model”
Vaccine 2008, 26, 5864-5873.
94. Partidos, C.D.; Hoebeke, J.; Wieckowski, S.; Chaloin, O.; Bianco, A.; Moreau, E.; Briand, J.-P.;
Desgranges, C.; Muller, S. “Immunomodulatory consequences of ODN CpG-polycation
complexes”
Methods 2009, 49, 328-333.
95. Podesta, J. E.; Al-Jamal, K. T.; Herrero, M. A.; Tian, B.; Ali-Boucetta, H.; Hegde, V.; Bianco, A.;
Prato, M.; Kostarelos, K. “Antitumor Activity and Prolonged Survival by Carbon NanotubeMediated Therapeutic siRNA Silencing in a Human Lung Xenograft Model”
Small 2009, 5, 1176-1185.
96. Zacchigna, M.; Klumpp, C.; Prato, M.; Bianco, A. “In vitro and in vivo behavior of multifunctionalized fullerene-warfarin conjugates”
Journal of Nanoscience and Nanotechnology 2009, 9, 6210-6221.
97. Gaillard, C.; Cellot, G.; Li, S.; Toma, F. M.; Dumortier, H.; Spalluto, G.; Cacciari, B.; Prato, M.;
Ballerini, L.; Bianco, A. “Carbon nanotubes carrying cell adhesion peptides do not interfere with
neuronal functionality”
98. Geotti-Bianchini, P.; Crisma, M.; Peggion, C.; Bianco, A.; Formaggio, F. “Conformationally
controlled, thymine-based α-nucleopeptides”
7
99. Singh, P.; Campidelli, S.; Giordani, S.; Bonifazi, D.; Bianco, A.; Prato, M. “Organic
Functionalisation and Characterisation of Single-Walled Carbon Nanotubes”
Chemical Society Reviews 2009, 38, 2214-2230.
100. Marega, R.; Aroulmoji, V.; Dinon, F.; Vaccari, L.; Giordani, S.; Bianco, A.; Murano, E.; Prato, M.
“Diffusion-Ordered NMR Spectroscopy in the Elucidation of Structural Modifications of Carbon
Nanotubes”
Journal of American Chemical Society 2009, 131, 9086-9093.
101. Herrero, M. A.; Toma, F. M.; Al-Jamal, K. T.; Kostarelos, K.; Bianco, A.; Bano, F.; Casalis, L.;
Scoles, G.; Prato, M. “Synthesis and Characterization of Polycationic Carbon Nanotubes for
siRNA Delivery”
102. Singh, P.; Kumar, J.; Toma, F. M.; Raya, J.; Prato, M.; Fabre, B.; Verma, S.; Bianco, A.
“Synthesis and Characterization of Nucleobase-Carbon Nanotube Hybrids”
103. Kostarelos, K.; Bianco, A.; Prato, M. “Promises, facts and challenges for carbon nanotubes in
imaging and therapeutics”
Nature Nanotechnology 2009, 4, 627-633.
104. Geotti-Bianchini, P.; Moretto, A.; Peggion, C.; Beyrath, J.; Bianco, A.; Formaggio, F.
“Replacement of Ala by Aib improves structuration and biological stability in thymine-based nucleopeptides”
105. Al-Jamal, K. T.; Al-Jamal, W. T.; Akerman, S.; Podesta, J. E.; Yilmazer, A.; Turton, J. A.; Bianco,
A.; Vargesson, N.; Kanthou, C.; Florence, A. T.; Tozer, G. M.; Kostarelos, K. “Systemic AntiAngiogenic Activity of Cationic Poly-L-Lysine Dendrimer Delays Tumor Growth”
Proceedings of the National Academy of Science, USA 2010, 107, 3966–3971.
106. Ben-Valid, S.; Dumortier, H.; Sfez, R.; Decossas, M.; Meneghetti, M.; Bianco, A.; Yitzchaik S.
“Polyaniline-Coated Single-Walled Carbon Nanotubes: Synthesis, Characterization and Impact on
Primary Immune Cells”
Journal of Material Chemistry 2010, 20, 2408–2417.
107. Samorì, C.; Ali-Boucetta, H.; Sainz, R.; Guo, C.; Toma, F. M.; Fabbro, C.; Da Ros, T.; Prato, M.;
Kostarelos, K.; Bianco A. “Enhanced anticancer activity of multi-walled carbon nanotubemethotrexate conjugates using cleavable linkers”
Chemical Communications 2010, 46, 1494-1496.
108. Ménard-Moyon, C.; Kostarelos, C.; Prato, M.; Bianco, A. “Functionalized carbon nanotubes for
probing and modulating molecular functions”
Chemistry and Biology 2010, 17, 107-115.
109. Samorì, C.; Sainz, R.; Ménard-Moyon, C.; Toma, F. M.; Venturelli, E.; Singh, P.; Ballestri, M.;
Prato M.; Bianco A. “Potentiometric titration as a straightforward method to assess the number of
functional groups on shortened carbon nanotubes”
Carbon 2010, 48, 2447-2454.
110. Marega, R.; Aroulmoji, V.; Bergamin, M.; Feruglio, L.; Dinon, F.; Bianco, A.; Murano, E.; Prato, M.
“Two Dimensional Diffusion-Ordered NMR Spectroscopy as a Tool for Monitoring Functionalized
Carbon Nanotube Purification and Composition”
ACS Nano 2010, 4, 2051-2058. DOI:10.1021/nn100257h
111. Fabre, B.; Ababou-Girard, S.; Singh, P.; Kumar, J.; Verma, S.; Bianco, A. “Noncovalent assembly
of ferrocene on modified gold surfaces mediated by uracil-adenine base pairs”
Electrochemistry Communications 2010, 12, 831-834.
8
112. Ménard-Moyon, C.; Venturelli, E.; Fabbro, C.; Samorì, C.; Da Ros, T.; Kostarelos, K.; Prato, M.;
Bianco, A. “The alluring potential of functionalized carbon nanotubes in drug discovery”
Expert Opinion in Drug Discovery 2010, 5, 691-707.
113. Van den Bossche, J.; Al Jamal, W. T.; Tian, B.; Nunes, A.; Fabbro, C.; Prato, M.; Bianco, A.;
Kostarelos, K. “Efficient receptor-independent intracellular translocation of aptamers mediated by
conjugation to carbon nanotubes”
Chemical Communications, 2010, 46, 7379-7381.
114. Al-Jamal, K. T.; Toma, F. M.; Yilmazer, A.; Ali-Boucetta, H.; Nunes, A.; Herrero, M. A.; Tian, B.;
Eddaoui, A.; Bianco, A.; Prato, M.; Kostarelos, K. “Enhanced cellular internalization and gene
silencing using a series of cationic dendron-multiwalled carbon nanotube:siRNA complexes”
FASEB Journal, 2010, 24, 4354-4365.
115. Cellot, G.; Prato, M.; Ballerini, L.; Bianco, A. “Neurons are able to internalize soluble CNT: new
opportunities or old risks?”
Small, 2010, 6, 2630–2633.
116. Gaillard, C.; Duval. M.; Dumortier, H.; Bianco, A. “Carbon nanotube-coupled cell adhesion
peptides are not immunogenic: a promising step toward new biomedical devices”
Journal of Peptide Science, 2011, 17, 139-142.
117. Russier, J.; Ménard-Moyon, C.; Venturelli, E.; Gravel, E.; Marcolongo, G.; Meneghetti, M.; Doris,
E.; Bianco, A. “Oxidative biodegradation of single- and multi-walled carbon nanotubes”
Nanoscale, 2011, DOI: 10.1039/c0nr00779j
118. Serag, M. F.; Kaji, N.; Gaillard, G.; Okamoto, Y.; Terasaka, K.; Jabasini, M.; Tokeshi, M.;
Mizukami, H.; Bianco, A.; Baba, Y. “Trafficking and sub-cellular localization of multi-walled carbon
nanotubes in plant cells”
ACS Nano 2011, DOI: 10.1021/nn102344t
119. Benincasa, M.; Pacor, S.; Wu, W.; Prato, M.; Bianco, A.; Gennaro, R. “Antifungal activity of
Amphotericin B conjugated to carbon nanotubes”
ACS Nano 2011, DOI:10.1021/nn1023522
120. Ménard-Moyon, C.; Fabbro, Prato, M.; Bianco, A. “One-Pot Triple Functionalization of Carbon
Nanotubes”
Chemistry: A European Journal, 2011, in press
121. Singh, P.; Samorì, C.; Toma, F. M.; Bussy, C.; Nunes, A.; Al-Jamal, K. T.; Ménard-Moyon, C.;
Prato, M.; Kostarelos, K.; Bianco, A. “Polyamine Functionalized Carbon Nanotubes: Synthesis,
Characterization, Cytotoxicity and siRNA Binding”
Journal of Materials Chemistry, 2011, accepted
CONGRESS PROCEEDINGS
1.
Mutter, M.; Bianco, A.; Buttkus, U.; Dörner, B.; Nyanguile, O.; Sila, U.; Zier, A.; Kamber, B.
“Redesigning Peptide Structures: Side-Chain Assemblage on Topological Templates”, in Peptides
1992, Schneider C. H. and Eberle A. N. Eds., ESCOM, Leiden, The Netherlands, 1993, 87-88.
2.
Crisma, M.; Bianco, A.; Formaggio, F.; Toniolo, C.; George, C.; Flippen-Anderson, J. L.
“Tryptophan-Containing Polypeptide 310-Helices: Side-Chain Interactions and Molecular
Recognition Studies”, in Recent Advances in Tryptophan Research, Allegri Filippini G., Costa C.
L. V. and Bertazzo A. Eds., Plenum Press, New York, 1996, 623-626.
3.
Bianco, A.; Maggini, M.; Novello, F.; Toniolo, C.; Scorrano, G.; Villani, C.; Da Ros, T.; Prato, M.
“Synthesis and Chiroptical Properties of Fullerene Derivatives”, in Fullerenes and Fullerene
Nanostructures, Kuzmany H., Fink J., Mehring M. and Roth S. Eds., World Scientific Publishing
Co., Singapore, 1996, 496-500.
9
4.
Bianco, A.; Maggini, M.; Mondini, S.; Polese, A.; Scorrano, G.; Toniolo, C.; Guldi, D. M.
“Synthesis and Characterization of a Peptide-Linked C60 Dyad”, in Recent Advances in the
Chemistry and Physics of Fullerenes and Related Materials, Kadish K. M. and Ruoff R. S. Eds.,
The Electrochemical Society Inc., Pennington NJ, 1998, 6, 1145-1151.
5.
Toniolo, C.; Polese, A.; Bianco, A.; Maggini, M.; Scorrano, G.; Guldi, D. M. “A Peptide Spacer in a
Fullerene(C60)-Based Donor-Acceptor Dyad”, in Peptides for the New Millennium, Field G. B., Tam
J. P. and Barany G. Eds., Kluwer Academic Publishers, Dordrecht, 2000, 503-504.
6.
Bianco, A.; Furrer, J.; Elbayed, K.; Raya, J.; Briand, J.-P. “A New Solid-Phase Strategy for the
Preparation of Hydroxyproline-Based Highly Substituted Diketopiperazines”, in Innovation and
Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2000, Epton R. Ed., Mayflower
Worldwide Limited, Kingswinford, 2001, 243-246.
7.
Bianco, A.; Furrer, J.; Piotto, M.; Bourdonneau, M.; Limal, D.; Guichard, G.; Elbayed, K.; Raya, J.;
Briand J.-P. “Do Bioactive Peptides Display Native-like Conformations when Bound to a Solid
Support?”, in Peptides: The Wave of the Future, Lebl M. and Houghten R. A. Eds., American
Peptide Society, San Diego CA, 2001, 402-403.
8.
Bianco, A.; Furrer, J.; Limal, D.; Guichard, G.; Elbayed, K.; Raya, J.; Piotto, M.; Briand J.-P.
“Hydroxyproline-Containing 2,5-Diketopiperazines: Synthesis on Different Solid Supports and
Characterization by HR-MAS NMR”, in Peptides 2000, Martinez J. and Fehrentz J. A. Eds., EDK,
Editions Médicales et Scientifiques, Paris, France, 2001, 953-954.
9.
Bianco, A.; Pantarotto, D.; Briand, J. P.; Prato, M. “Solid phase synthesis of bioactive fulleropeptides”, in Peptides 2002, Benedetti, E. and Pedone C. Eds., Edizioni Ziino, Napoli, Italy, 2002,
42-43.
10. Bianco, A.; Lancelot, N.; Elbayed, K.; Raya, J.; Piotto, M.; Briand, J.P.; Formaggio F.; Toniolo, C.
“Characterization of the 310-Helix by HRMAS NMR Spectroscopy”, in Peptides 2002, Benedetti E.
and Pedone C. Eds., Edizioni Ziino, Napoli, Italy, 2002, 352-353.
11. Tasis, D.; Tagmatarchis, N.; Georgakilas, V.; Pantarotto, D.; Vaccari, L.; Bianco, A.; Guldi, D. M.;
Prato M. “Organic Functionalization of Carbon Nanotubes” in Electronic Properties of Novel
Materials: Molecular Nanostructures, Kuzmany H., Fink J., Mehring M. and Roth S. Eds., The
American Institute of Physics, Woodbury, New York, AIP Conference Proceedings, 2003, 685,
282-286.
12. Tasis, D.; Tagmatarchis, N.; Georgakilas, V.; Prato M.; Pantarotto, D.; Bianco, A.; Guldi, D. M.
“Applications of Soluble Carbon Nanotubes” in Fullerenes and Nanotubes: The Building Blocks of
Next Generation Nanodevices, Guldi D. M., Kamat P. V. and D'Souza F. Eds., The
Electrochemical Society Inc., Pennigton, NJ, 2003, 13, 264-268.
13. Pantarotto, D.; Partidos, C. D.; Hoebeke, J.; Briand, J.-P.; Prato, M.; Bianco, A. “Organic
Functionalization of Carbon Nanotubes with Peptides”, in Peptide Revolution: Genomics,
Proteomics and Therapeutics, Chorev M. and Sawyer T. K. Eds., American Peptide Society,
Boston MA, 2003, 414-415.
14. Pantarotto, D.; Partidos, C. D.; Tagmatarchis, N.; Georgakilas, V.; Hoebeke, J.; Brown, F.;
Kramer, E.; Briand, J.-P.; Muller, S.; Prato, M.; Bianco, A. “Potential of Carbon Nanotubes in
Vaccine Delivery”, in Innovation and Perspectives in Solid Phase Synthesis & Combinatorial
Libraries, Epton R. Ed., Mayflower Worldwide Limited, Kingswinford, 2004, 147-150.
15. Bianco, A.; Pastorin, G.; Wu, W.; Klumpp, C.; Pantarotto, D.; Wieckowski, D.; Dumortier, H.;
Godefroy, S.; Lacotte, S.; Muller, S.; Singh, R.; Lacerda, L.; Kostarelos, K.; Hoebeke, J.; Partidos,
H.; Briand, J.-P.; Prato M. “Les nanotubes de carbone fonctionnalisés: un nouveau système de
vectorisation de molécules thérapeutiques” in Nano-objets aux interfaces, Prouzet E. Ed.,
Conference Proceeding, 2005, 35-38.
16. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Mechanism of cellular interaction, binding and
internalization of functionalized carbon nanotubes” in Technical Proceedings of the 2008 NSTI
10
Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2, 232235.
17. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Improved tissue distribution, renal clearance
and toxicity profile of functionalized carbon nanotubes” in Technical Proceedings of the 2008 NSTI
Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2, 509511.
18. Geotti-Bianchini, P.; Crisma, M.; Peggion, C.; Bianco, A.; Formaggio F. “Synthesis and 3Dstructure of conformationally controlled nucleo-peptides” Adv. Exp. Med. Biol. 2009, 611, 37-38.
19. Guichard, G.; Trouche, N.; Wieckowski, S.; Sun, W.; Chaloin, O.; Bianco, A.; Hoebeke, J.;
Schneider, P.; Fournel, S. “Rationally-designed multivalent architectures for mimicking
homotrimers of CD40L, a member of the TNF superfamily” Adv. Exp. Med. Biol. 2009, 611, 355357.
POSTER COMMUNICATIONS
1.
Bianco, A.; Maggini, M.; Prato, M.; Toniolo, C.; Scorrano, G. “Fullerene-Based α-Amino Acids
and Peptides”, in New Perspectives in Fullerene Chemistry and Physics, Rome (Italy), 1994, P17.
2.
Benedetti, E.; Del Duca, V.; Saviano, M.; Di Blasio, B.; Pedone, C.; Bianco, A.; Formaggio, F.;
Crisma, M.; Bonora, G. M.; Toniolo, C.; Aubry, A. “The Polypeptide 310-Helix as a Potential
th
Template for Molecular and Chiral Recognition Studies”, in 14 American Peptide Symposium,
Columbus (Ohio), 1995, P548.
3.
Toniolo, C.; Bianco, A.; Maggini, M.; Scorrano, G.; Prato, M. “Fullerene-Based α-Amino Acids
th
and Peptides”, in 14 American Peptide Symposium, Columbus (Ohio), 1995, P255.
4.
Bianco, A.; Brock, C.; Walden, P.; Jung, G. “Synthesis of Novel Oligomers as Potential Ligands
for Major Histocompatibility Class I Molecules”, in 3. Deutsches Peptidkolloquium, Konstanz
(Germany), 1997, P36.
5.
Bianco, A.; Kaiser, D.; Walk, T.; Jung, G. “Solid-Phase Synthesis and Properties of N-Hydroxy
Amide Containing Peptides”, in Workshop on Peptide Modification by Non-Natural Amino Acids,
Leipzig (Germany), 1997, P13.
6.
Bianco, A.; Gasparrini, F.; Maggini, M.; Misiti, D.; Polese, A.; Prato, M.; Scorrano, G.; Toniolo, C.;
Villani, C. “Synthesis and Applications of Fullerene-Based Amino Acids and Peptides”, in
Chemistry and Physics of Multifunctional Materials: Fullerenes in Context, Esphinho (Portugal),
1997, P4.
7.
Bianco, A.; Polese, A.; Mondini, S.; Maggini, M.; Toniolo, C.; Scorrano G.; Guldi, D. M. “Peptide
Templates and Spacers in Fullerene-Based Host-Guest Interactions and Donor-Acceptor Dyads”,
th
in 6 Naples Workshop on Bioactive Peptides, Capri (Italy), 1998, PII-28.
8.
Bianco, A.; Maggini, M.; Polese, A.; Villani, C.; Gasparrini, F.; Misiti, D.; Prato, M.; Toniolo, C.;
Scorrano, G.; Guldi, D. M. “Molecular Recognition of Fullerene-C60 Derivatives by Peptide
Templates”, in Supramolecular Chemistry, Advanced Materials, Kerkrade (The Netherlands),
1998, P7.
9.
Bianco, A.; Brock, C.; Zabel, C.; Hin, S.; Walk, T.; Walden, P.; Jung G. “Poly-N-Acylated Amines
rd
as Novel Ligands for Major Histocompatibility Class I Molecules and as T Cell Epitopes”, in 3
Peptido- and Proteino-Mimetics Symposium, Houffalize (Belgium), 1999, P4.
10. Elbayed, K.; Furrer, J.; Raya, J.; Hirschinger, J.; Piotto, M.; Bourdonneau, M.; Bianco, A.;
Guichard, G.; Limal, D.; Briand J.-P. “Study of the HRMAS Technique: Importance of the Resin
Choice”, in Franco-Italian Conference on Magnetic Resonance, La Londe Les Maures (France),
2000, P48.
11
Guichard, G.; Limal, D.; Briand J.-P. “Study of the HRMAS Technique: Anisotropic Bulk Magnetic
th
Susceptibilities and Residual Static Dipolar Interaction”, in 26 European Peptide Symposium,
Montpellier (France), 2000, P219.
Guichard, G.; Limal, D.; Briand J.-P. “New Approach of HRMAS Technique Using Solid State
th
NMR Methods: Detection of Dipolar Interactions Between Distant Nuclei”, in 26 European
Peptide Symposium, Montpellier (France), 2000, P220.
13. Lancelot, N.; Raya, J.; Guichard, G.; Semetey, V.; Briand J.-P.; Bianco, A.; Piotto, M.; Elbayed, K.
ème
“Etude par HRMAS d’oligo-urées greffés sur support solide”, in 12
Réunion Peptides et
Protéines, Aussois (France), 2002, P2.a16.
14. Bianco, A.; Furrer, J.; Elbayed, K.; Bourdonneau, M.; Raya, J.; Limal, D.; Guichard, G.; Piotto, M.;
Briand J.-P. “La spectroscopie RMN haute résolution à l’angle magique (HRMAS) une technique
ème
très performante pour la caractérisation des molécules greffées sur un support solide”, in 12
Réunion Peptides et Protéines, Aussois (France), 2002, P7.a3.
15. Poschalko, A.; Knaus, S.; Gruber, H.; Bianco, A.; Guichard, G.; Briand J.-P.; Falkenhagen, D.
“Novel Sucrose-based Hydrophilic Polymer Supports for Solid Phase Peptide Synthesis” in
Funktionspolymere für Systemlösungen, GDCh, Darmstadt (Germany), 2002, M2.
16. Poschalko, A.; Knaus, S.; Gruber, H.; Bianco, A.; Guichard, G.; Briand J.-P.; Weber, V.;
Falkenhagen, D. “Influence of the Polymer Support on Fibrinogen-Adsorption in Affinity
Chromatography” in Funktionspolymere für Systemlösungen, GDCh, Darmstadt (Germany), 2002,
M12.
17. Bianco, A.; Guldi, D. M.; Crisma, M.; Sartori, E.; Corvaja, C.; Maggini M.; Toniolo, C. “A Helical
th
Peptide Receptor for [60]Fullerene” in 27 European Peptide Symposium, Sorrento (Italy), 2002,
P B51.
18. Pantarotto, D.; Bianco, A.; Pellarini, F.; Tossi, A.; Giangaspero, A.; Zelezetsky, I.; Briand, J. P.;
Prato M. “Synthesis and biological properties of fullerene-based peptides” in SAJEC 2002,
Obernai (France), 2002, P53.
19. Pantarotto, D.; Georgakilas, V.; Tagmatarchis, N.; Briand, J.-P.; Prato, M.; Bianco, A. “Organic
Functionalization of Carbon Nanotubes with Amino Acids“ in Nanobiotechnologies II, Grenoble
(France), 2003, PO3.5.
“
20. Pantarotto, D.; Partidos, C. D.; Hoebeke, J.; Briand, J.-P.; Prato, M.; Bianco, A. Synthesis,
characterization and biological properties of peptides-carbon nanotubes conjugates“ in
Nanoscience and Technology Conference, Groningen (The Netherlands), 2003, P-38.
“
21. Pantarotto, D.; Partidos, C. D.; Hoebeke, J.; Briand, J.-P.; Prato, M.; Bianco, A. Organic
th
functionalization of carbon nanotubes with peptides“ in 18 American Peptide Symposium, Boston
(Massachusetts), 2003, P517.
22. Wieckowski, S.; Trouche, N.; Chaloin, O.; Bianco, A.; Hoebeke, J.; Dumortier, H.; Guichard, G.;
Fournel, S. “A synthetic multimeric ligand of CD40 is able to mimic effector functions of the natural
CD40L” in Congrès Annuel SFI, Paris (France), 2004, P50.
23. Poschalko, A.; Lancelot, N.; Marin, J.; Larras, V.; Limal, D.; Elbayed, K.; Raya, J.; Piotto, M.; Briand,
J.-P.; Bianco, A.; Guichard, G. “DEUSS: Une résine perdeutérée pour la synthèse et l’analyse
ème
RMN HRMAS des molécules supportées“ in 14
Réunion Peptides et Protéines, Aussois
(France), 2005, PA22.
24. Pastorin, G.; Wu, W.; Wieckowski, S.; Briand, J.-P.; Prato, M.; Bianco, A. “Multiple
Functionalization of Carbon Nanotubes“ in Biological Surfaces and Interfaces, EuroConference on
Biomaterials, Biosensors and Analytical Techniques, Sant Feliu de Guixols (Spain), 2005.
12
25. Dumortier, H.; Lacotte, L.; Pastorin, G.; Wu, W.; Marega, R.; Bonifazi, D.; Prato, M.; Briand, J.-P.;
Muller S.; Bianco, A. “Impact des nanotubes de carbone fonctionnalisés sur les cellules du
système immunitaire“ in Nano-objets aux interfaces, Montpellier (France), 2005, P82.
26. Dumortier, H.; Lacotte, L.; Pastorin, G.; Marega, R.; Wu, W.; Bonifazi, D.; Prato, M.; Briand, J.-P.;
Muller S.; Bianco, A. “Impact of functionalized carbon nanotubes on murine primary immune
cells” in Nanomedicine 2006, ESF-UB Conference, San Feliu de Guixols (Spain), 2006, Pxx.
27. Lacotte, S.; Dumortier, H.; Pastorin, G.; Marega, R.; Wu, W.; Bonifazi, D.; Briand, J.-P.; Prato, M.;
Muller, S.; Bianco, A. “Investigation on the impact of functionalized carbon nanotubes on primary
mouse immune cells” in GDR-E 2006, Obernai (France), 2006, P33.
28. Geotti-Bianchini, P.; Crisma, M.; Bianco, A.; Formaggio, F. “Synthesis and 3D-structure of
ème
conformationally controlled nucleo-peptides” in 15
Réunion du Groupe Français des Peptides
et Protéines, Dinard (France), 2007, P58.
29. Geotti-Bianchini, P.; Crisma, M.; Bianco, A.; Formaggio, F. “Synthesis and 3D-structure of
th
conformationally controlled nucleo-peptides” in 20 American Peptide Symposium, Montreal
(Canada), 2007, P138.
30. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Improved Biodistribution and Toxicity Profiles
of Functionalised Carbon Nanotubes” in NT07, Ouro Preto (Brasil), 2007, PC26.
31. Bianco, A.; Dumortier, H.; Lacotte, S.; Pastorin, G.; Wu, W.; Decossas, M.; Marega, R.; Bonifazi,
D.; Briand, J.-P.; Muller, S.; Prato, M. “Impact of Functionalized Carbon Nanomaterials on the
Immunocompetent Cells” in NT07, Ouro Preto (Brasil), 2007, PC33.
32. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Mechanisms for the Cellular Internalization of
Functionalized Carbon Nanotubes ” in NT07, Ouro Preto (Brasil), 2007, PD39.
33. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Carbon Nanotubes: Biodistribution, Toxicity &
Gene Delivery” in ESF Summer School in Nanomedicine, Hensol (UK), 2007.
34. Lacotte, S.; Garcia, A.; Décossas, M.; Al-Jamal, W. T.; Li, S.; Kostarelos, K.; Muller, S.; Prato, M.;
Dumortier, H.; Bianco, A. “ Interfacing functionalized carbon nanohorns with primary phagocytic
cells” in Probing Interactions Between Nanoparticles/Materials and Biological Systems, ESFEMBO Conference, San Feliu de Guixols (Spain), 2007, P36.
35. Lacerda, L.; Prato, M.; Bianco, A.; Kostarelos, K. “Mechanisms of Cellular Interaction, Binding
and Uptake of Functionalised Carbon Nanotubes” in Probing Interactions Between
Nanoparticles/Materials and Biological Systems, ESF-EMBO Conference, San Feliu de Guixols
(Spain), 2007.
36. Benincasa, M.; Pacor, S.; Prato, M.; Wu, W.; Bianco, A.; Gennaro, R. Antifungal activity of
th
amphotericin B conjugated to functionalized carbon nnaotubes” ” in 52 Congresso Nazionale
della Società Italiana di Biochimica, Riccione (Italy), 2007.
37. Geotti-Bianchini, P.; Crisma, M.; Bianco A.; Formaggio F. “Synthesis and 3D-structure of
conformationally controlled nucleopeptides” in National Meeting of Chemistry of Biological
Systems, Italian Chemical Society, SCI- Section CSB, Montagnana (Italy), 2007, P19.
38. Geotti-Bianchini, P.; Beyrath, J.; Chaloin, O.; Decossas, M.; Bianco, A.; Formaggio, F. “Design
and synthesis of cell-penetrating nucleopeptides” in National Meeting of Chemistry of Biological
Systems, Italian Chemical Society, SCI- Section CSB, Riccione (Italy), 2008.
39. Gaillard, G.; Li, S.; Dumortier, H.; Prato, M.; Bianco, A. “Functionalizatino of carbon nanotubes
with bioactive peptides” in ChemOnTubes, Zaragoza (Spain) 2008, P5.
40. Garcia, A.; Lacotte, S.; Décossas, M.; Al-Jamal, W. T.; Li, S.; Kostarelos, K.; Muller, S.; Prato, M.;
Dumortier, H.; Bianco, A. “Functionalization of carbon nanohorns and their interaction with
primary phagocytic cells” in ChemOnTubes, Zaragoza (Spain) 2008, P6.
13
41. Herrero, M. A.; Bianco, A.; Kostarelos, K.; Prato, M. “Functionalization, Application and
Characterization of the Carbon Nanotubes” in ChemOnTubes, Zaragoza (Spain) 2008, P12.
42. Saniz, R.; Benincasa, M.; Gennaro, R.; Prato, M.; Bianco A. “ Functionalisation of Carbon
Nanotubes with antifungal agents” in ChemOnTubes, Zaragoza (Spain) 2008, P131.
43. Toma, F. M.; Herrero, Chamorro, M. A.; Bianco, A.; Kostarelos, K.; Scaini, D.; Casalis, L.; Scoles,
G.; Prato, M. “Covalent functionalization of carbon nanotubes for biological applications” in
ChemOnTubes, Zaragoza (Spain) 2008, P136.
44. Ménard-Moyon, C.; Dumortier, H.; Bianco, A. “Carbon-based nanobiomaterials and delivery” in
Journée NanoSMS en Alsace, Strasbourg (France) 2008.
45. Ménard-Moyon, C.; Dumortier, H.; Bianco, A. “Carbon-based nanobiomaterials and delivery” in
ère
NanoSMS, 1 Journée Scientifique du Réseau de Recherche Inter-Régional NanoSciences et
Matériaux pour la Santé, Nancy (France) 2009.
46. Dumortier, H.; Ben-Valid, S.; Décossas, M.; Sfez, R.; Meneghetti M.; Yitzchaik, S.; Bianco, A.
“Impact of polyaniline-coated single-walled carbon nanotubes on primary immune cells” in
ChemOnTubes, Arcachon (France) 2010, P33.
47. Bianco A.; Samorì, C.; Sainz, R.; Ménard-Moyon, C.; Venturelli, E.; Singh, P.; Ballestri, M.; Toma,
F. M.; Prato M. “Oxidized multi-walled carbon nanotubes with a narrow length distribution” in
ChemOnTubes, Arcachon (France) 2010, P14.
48. Samorì, C.; Ali-Boucetta, H.; Sainz, R.; Guo, C.; Toma, F. M.; Fabbro, C.; Da Ros, T.; Prato, M.;
Kostarelos, K.; Bianco, A. “Effect of cleavable linkers on anticancer activity of carbon nanotube
functionalized with methotrexate” in ChemOnTubes, Arcachon (France) 2010, P98.
PATENTS
1.
Guichard, G., Fournel S., Bianco, A., Hoebeke, J., Muller, S. “Nouvelles molécules multimériques
leur procédé de préparation, et leur utilisation pour la préparation de médicaments”
French patent: N°02/06631 (30 of May 2002)
International patent: N°PCT/FR03/01613 (28 of May 2 003)
2.
Bianco A., Pantarotto, D., Prato, M. “Functionalized carbon nanotubes, a process for preparing
the same and their use in medical chemistry”
International patent: N°PCT/EP03/03838 (14 of Apri l 2003)
International patent: N°PCT/WO2004/089818 (21 of O ctober 2004)
International patent: N°PCT/EP03/03829 (9 of April 2004)
International patent: N°PCT/WO2004/089819 (21 of O ctober 2004)
US 2006/0199770 (7 of September 2006)
3.
Bianco A., Pantarotto, D., Kostarelos, K., Prato, M. “Non-covalent complexes comprising carbon
nanotubes”
European patent: N° 04 291 440.8 (9 of June 2004)
PCT/EP2005/006036 (6 of June 2005)
International patent: WO 2005/121799 (22 of December 2005)
BOOK CHAPTERS
1.
Bianco, A. “Combinatorial Synthetic Oligomers”, in Combinatorial Chemistry, Jung G. Ed., WileyVCH, Weinheim, 1999, pp. 257-290.
2.
Bianco, A.; Wu, W.; Pastorin, G.; Klumpp, C.; Lacerda, L.; Partidos, C. D.; Kostarelos, K.; Prato
M. “Carbon nanotube-based vectors for delivering immunotherapeutics and drugs”, in
,
14
Nanomaterials for Medical Diagnosis and Therapy, Kumar C. Ed., Wiley-VCH, Weinheim, 2007,
pp.85-142.
3.
Bianco, A.; Da Ros, T. “Biological applications of fullerenes”, in Fullerenes, RSC Nanoscience
and Nanotechnology Series, Langa de la Puente F. et Nierengarten J.-F. Eds., The Royal Society
of Chemistry, Cambridge, UK, 2007, pp.301-328.
4.
Bianco, A.; Sainz, R.; Li, S.; Dumortier, H.; Lacerda, L.; Kostarelos, K.; Giordani, S. Prato, M.
“Biomedical applications of functionalised carbon nanotubes”, in Topics in Carbon Materials
Chemistry and Physics, Cataldo F. and Da Ros T. Eds., Springer, Germany, 2008, pp. 23-50.
5.
Singh, P.; Da Ros, T.; Kostarelos, K.; Prato, M.; Bianco, A. “Carbon-based Nanomaterial
Applications in Biomedicine” in Carbon Nanotubes and Related Structures, Guldi D. M. and Martin
N. Eds., Wiley-VCH, Weinheim, 2010, pp. 199-232.
HIGHLIGHTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
“Organic chemistry”, Chem. Ind., 1994, 303.
th
“Nanotubes go biological”, C&EN, 81(21), p. 28, 26 May 2003.
“Vaccine delivery by carbon nanotubes”, Chem. Biol. 2003, 10, 897-898.
“Designer drug delivery”, Materials Today 2003, 6, 21.
“Beyond pills and jabs”, Lancet 2003, 362, 1984-1985.
th
“Carbon nanotubes show drug delivery promise”, NewScientist.com news service, 16 December
2003.
th
“Nanotubes cross cell membranes”, C&EN, 82(2), p. 35, 12 January 2004.
“French, Italian researchers developing drug delivery system with carbon nanotubes”,
NanoBiotech News 2004, 2(2), 8.
“Biomaterialsts promise ‘nanovehicles’ to deliver drugs”, Chemical Science 2004, 1, C4.
rd
“Caccia al brevetto nel Science Park” Il Sole-24 (inserto Nord-Est), 6(6), p.12, 23 January 2004.
th
“Les nanotubes de carbone comme vecteurs thérapeutiques”, L’Usine Nouvelle, p.3, 29 January
2004.
“For Science, Nanotech Poses Big Unknowns”, Washington Post, page A01, Sunday, February 1,
2004.
“Des nanotubes livreurs de médicaments”, Le journal du CNRS 2004, 170-171, 12.
th
“Des nanotubes de carbone pour délivrer des drogues”, Biotech.Info, 222, p.6, 28 April 2004.
th
“Carbon nanotubes offer a new approach to gene therapy”, www.news-medical.net, 11 October
2004.
th
“Wie injiziert man ein Gen?”, www.wissenschaft-online.de, Spektrumdirekt (Biochemie) 12
October 2004.
th
“Nano-Nadel für die Injektion von Genen?”, www.Chimie.de, 13 October 2004.
th
“Nano-Nadel für die Injektion von Genen?”, www.Bionity.com, 13 October 2004.
“Nanotubes for plamsid DNA gene delivery”, Nano Today, December 2004, 10.
“Molecular Needles”, http://www.iproms.org/aggregator/sources/12?from=20, www.nanotechnow.com, http://pda.physorg.com/lofinews6587.html,
th
http://www.voyle.net/Nano%20Medicine%202005%20100+/Medicine%202005-0114.htm, 19
September 2005.
“Carbon nanotubes as transport agents for antimycotics (antifungal agents)”, www.newsth
medical.net, 19 September 2005.
st
“Molekulare Injektionsnadeln”, www.wissenschaft-online.de, Spektrumdirekt (Pharmakologie) 21
September 2005.
“Carbon nanotubes as molecular needles”, http://www.nanovip.com,
http://www.gtp.or.kr/antp/new_tech/view.jsp?cPage=1&gubun=001&menu=71&no=90524&idx=14
th
940&left=2, 21 September 2005.
th
“NMR - Drug delivery down the tubes”, www.spectroscopyNOW.com, 26 September 2005.
th
“Nanotubes May Deliver Drugs to Targeted Cells”, www.4woman.gov, 30 September 2005.
“French, Italian researchers deliver antifungal with carbon nanotubes”, NanoBiotech News 2005,
3, 3.
th
“Le nanotube de carbone nouveau mode de transport”, L’Usine Nouvelle, N°2987, p.74, 24
November 2005.
“Toward small-molecule agonists of TNF receptors” Nat. Chem. Biol. 2005, 1, 353-354.
15
29. “Immune boosters” Nature 2005, 438, 132.
30. “Targeted Delivery of Amphotericin B to Cells Accomplished with Functionalized CNTs” MRS
Bulletin, December 2005, 30, 927.
31. “TNFR superfamily trimers” Nat. Rev. Drug Discov. 2006, 5, 20.
th
32. “Carbon nanotubes pass through body fast”, www.nanotechweb.org/articles/news/5/2/7/1, 15
February 2006.
th
33. “Carbon Nanotubes Pass Safety Test”, C&EN, 84(8), p. 8, 20 February 2006.
34. “Nanoscale transport offers controlled drug delivery”, Chemical Biology, 2006, 1, B15.
th
35. “Nanoneedles pierce cells”, C&EN, 85(6), p. 10, 5 February 2007.
th
36. “Du nanotube de carbone à la nanoseringue” Chimie Pharma Hebdo, N° 373, p.18, 26 February
2007.
37. “Nanotube, passeport d’entrée dans la cellule” IndustriePharma, p.66, Avril/Mai 2007.
38. “Crossing biological barriers with nanotubes” Nat. Methods 2007, 4, 299.
39. “'Nanohorns'
could
prod
immune
system
into
action”
http://technology.newscientist.com/channel/tech/dn14170-nanohorns-could-prod-immune-systemth
into-action.html, 19 June 2008.
40. “Zoom/Nanotechnologies” Dernières Nouvelles d’Alsace, N.243 p.2, 17 October 2009.
41. “Les nanotubes de carbone toujours à l’assai” Le Figaro, p.14, 19 October 2009.
42. “Les nanotechnologies sont-elles dangereuses?” Science et Vie Junior, N.246, p.18, March 2010.
43. “Electron transit through iron compound” Nature India, Published online 9 June 2010.
Doi:10.1038/nindia.2010.76.
44. “Hot: Biodegradation of carbon nanotubes” http://blogs.rsc.org/nr/2010/12/06/hot-biodegradationof-carbon-nanotubes/ 6 December 2010.
CORRESPONDENCE
1.
Kostarelos, K.; Bianco, A.; Prato, M; “Hype around nanotubes creates unrealistic hopes” Nature
2008, 453, 280.
2.
Bianco A. “Les nanotubes de carbone: un nouvel outil contre le cancer”
Médecine Sciences 2009, 25, 125-127.
3.
Kostarelos, K.; Bianco, A.; Prato, M. “Complement monitoring of carbon nanotubes”
Nature Nanotechnology 2010, 5, 382-383. DOI:10.1038/nnano.2010.110
16

alberto bianco - curriculum vitae

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