CV - European Medicines Agency

Curriculum vitae
PERSONAL INFORMATION
Catherine SADZOT
WORK EXPERIENCE
September 1984–February 1991
Assistant Lecturer/PhD Student
University of Liège (Belgium)
PhD thesis on Varicella Zoster Virus: "Modèles d'infection persistante du système nerveux par le virus
de la Varicelle et du Zona (VZV)" (In vivo and in vitro models of persistant infections of the nervous
system by the Varicella Zoster Virus )
August 1995–August 1996
PostDoc
University of Liège (Belgium)
Postdoc position in the Division of Infectious Diseases,
Department of Pediatrics, University school of medecine, Stanford, California, Dr. Ann Arvin's Lab
September 1996–Present
Principal investigator
University of Liège (Belgium)
PI of the Varicella Zoster Virus group (http://www.giga.ulg.ac.be/cms/c_21986/fr/laboratoire-devirologie-et-immunologie-home)
September 1996–Present
Professor
University of Liège (Belgium)
Immunology -Bac and Master level
EDUCATION AND TRAINING
October 1980–July 1982
Bacchelor in Biology
University of Liège (Belgium)
October 1982–September 1984
Master in Biology
University of Liège (Belgium)
Animal Biology
September 1984–February 1991
PhD in Sciences
University of Liège (Belgium)
In vivo and in vitro models of persistant infections of the nervous system by the Varicella Zoster Virus
ADDITIONAL INFORMATION
Expertise
Virology,
Immunology,
Vaccine
Publications
Publications et communications de Catherine Sadzot
1. Theses
1.a. PhD Thesis
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Curriculum vitae
Catherine SADZOT
Sadzot, C. (1991). Modèles d'infection persistante du système nerveux par le virus de la Varicelle et
du Zona (VZV). Unpublished doctoral thesis, Université de Liège, Liège, Belgique.
1.b. Master Thesis
Sadzot, C. (1984). Infection du souriceau nouveau-né par le virus du cancer mammaire de la souris
(MMTV): Influence de l'âge, de la dose et de la réponse immunitaire. Unpublished master thesis,
Université de Liège, Liège, Belgique.
2. Articles is peer reviewed journals
As first or last author
• Lebrun, M., Thelen, N., Thiry, M., Riva, L., Ote, I., Conde, C., Vandevenne, P., Di Valentin, E.,
Bontems, S., & Delvaux-Sadzot, C. (2014). Varicella-zoster virus induces the formation of dynamic
nuclear capsid aggregates. Virology, 454-455, 311-27.
• Riva, L., Thiry, M., Lebrun, M., L'Homme, L., Piette, J., & Delvaux-Sadzot, C. (2014). Deletion of the
ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids. Journal of virology. J
Virol. 89(4):2436-41
• Riva, L., Thiry, M., BONTEMS, S., Joris, A., Piette, J., Lebrun, M., & Sadzot, C. (2013). ORF9p
phosphorylation by ORF47p is crucial for the formation and egress of the Varicella-zoster virus (VZV)
viral particles. J. of Virol., 87(5), 2868-2881.
• Vandevenne, P., Lebrun, M., El Mjiyad, N., Ote, I., Di Valentin, E., Habraken, Y., Dortu, E., Piette, J.,
& Sadzot, C. (2011). The varicella-zoster virus ORF47 kinase interferes with host innate immune
response by inhibiting the activation of IRF3. PLoS ONE, 9(2)
• Ote, I., Piette, J., & Sadzot-Delvaux, C. (2010). The Varicella-Zoster virus IE4 protein: a conserved
member of the herpesviral mRNA export factors family and a potential alternative target in antiherpetic
therapies. Biochemical Pharmacology, 80,
• Ote, I., Vandevenne, P., Bontems, S., Medina-Palazon, C., Manet, E., Piette, J., Lebrun, M., &
Sadzot-Delvaux, C. (2009). Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports
mRNAs through the TAP/NXF1 Pathway. PLoS ONE, 4(11), 7882. http://hdl.handle.net/2268/33834
• Sadzot-Delvaux, C., Rentier, B., Wutzler, P., Asano, Y., Suga, S., Yoshikawa, T., & Plotkin, S. A.
(2008). Varicella vaccination in Japan, South Korea, and Europe. Journal of Infectious Diseases, 197
Suppl 2, 185-90.
• El Mjiyad, N., Bontems, S., Gloire, G., Horion, J., Vandevenne, P., Dejardin, E., Piette, J., & SadzotDelvaux, C. (2007). Varicella-zoster virus modulates NF-kappaB recruitment on selected cellular
promoters. Journal of Virology, 81(23),
• Sadzot-Delvaux, C., Di Valentin, E., & Bontems, S. (2006). Le virus de la varicelle et du zona : un
alphaherpesvirus pas vraiment comme les autres. Virologie, 10(3), 219-232.
• Kennedy, P. G., Grinfeld, E., Bontems, S., & Sadzot-Delvaux, C. (2001). Varicella-Zoster virus gene
expression in latently infected rat dorsal root ganglia. Virology, 289(2), 218-23.
• Rentier, B., & Sadzot-Delvaux, C. (2000). Le virus de la varicelle et du zona dans le système
nerveux : retraite silencieuse ou guérilla permanente ? Virologie, 4(3), 207-216
• Sadzot-Delvaux, C., Arvin, A. M., & Rentier, B. (1998). Varicella-zoster virus IE63, a virion
component expressed during latency and acute infection, elicits humoral and cellular immunity.
Journal of Infectious Diseases, 178(Suppl. 1), 43-S47.
• Sadzot-Delvaux, C., Kinchington, P. R., Debrus, S., Rentier, B., & Arvin, A. M. (1997). Recognition of
the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory Tlymphocytes. Journal of Immunology, 159(6),
• Sadzot-Delvaux, C., Debrus, S., Nikkels, A., Piette, J., & Rentier, B. (1995). Varicella-zoster virus
latency in the adult rat is a useful model for human latent infection. Neurology, 45(12, suppl. 8), 18S20.
• Sadzot-Delvaux, C., Thonard, P., Schoonbroodt, S., Piette, J., & Rentier, B. (1995). Varicella-zoster
virus induces apoptosis in cell culture. Journal of General Virology (The), 76(Pt 11), 2875-2879.
• Snoeck, R., Andrei, G., De Clercq, E., Gerard, M.-C., Clumeck, N., Tricot, G., & Sadzot-Delvaux, C.
(1993). A new topical treatment for resistant herpes simplex infections. New England Journal of
Medicine [=NEJM], 329(13), 968-9.
• Sadzot-Delvaux, C., Marc, P., Lebon, L., Merville, M.-P., Piette, J., & Rentier, B. (1992). Antibodies to
varicella-zoster virus modulate antigen distribution but fail to induce viral persistence in vitro. Journal of
Virology, 66(12), 7499-504.
• Sadzot-Delvaux, C., Merville, M.-P., Delrée, P., Marc, P., Piette, J., Moonen, G., & Rentier, B. (1990).
An in vivo model of varicella-zoster virus latent infection of dorsal root ganglia. Journal of
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Neuroscience Research, 26(1), 83-89.
• Sadzot-Delvaux, C., Merville, M.-P., Bourdon-Wouters, C., Delrée, P., Piette, J., Moonen, G., &
Rentier, B. (1988). In vitro and in vivo models of varicella-zoster virus persistence in the nervous
system. Journal of Cellular Biochemistry, 12C, 30.
As co-auteur
• Bonanni, P., Gershon, A., Gershon, M., Kulcsár, A., Papaevangelou, V., Rentier, B., Sadzot, C.,
Usonis, V., Vesikari, T., Weil- Olivier, C., de Winter, P., & Wutzler, P. (2013). Primary Versus Secondary
Failure After Varicella Vaccination: Implications for Interval Between 2 Doses. Pediatric Infectious
Disease Journal, 32(7), 305-313.
• Lecat, A., Di Valentin, E., Somja, J., Jourdan, S., Fillet, M., Kufer, T., Habraken, Y., Sadzot, C., Louis,
E., Delvenne, P., Piette, J., & Legrand-Poels, S. (2012). The c-jun N-terminal Kinase (JNK)-binding
Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its
Oligomerization Process. Journal of Biological Chemistry, 287(35), 29213-26.
http://hdl.handle.net/2268/125587
• Vandevenne, P., Sadzot-Delvaux, C., & Piette, J. (2010). Innate immune response and viral
interference strategies developed by Human Herpeviruses. Biochemical Pharmacology, 80, 19551972.
• Bonanni, P., Breuer, J., Gershon, A. A., Gershon, M., Hryniewicz, W., Papaevangelou, V., Rentier, B.,
Rumke, H., Sadzot- Delvaux, C., Senterre, J., Weil-Olivier, C., & Wutzler, P. (2009). Varicella
vaccination in Europe – taking the practical approach. BMC Medicine, 7(26), 1-38.
• Habran, L., El Mjiyad, N., Di Valentin, E., Sadzot-Delvaux, C., Bontems, S., & Piette, J. (2007). The
varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a
cell-type dependent manner. BMC Molecular Biology, 8, 99. http://hdl.handle.net/2268/1114
• Vesikari, T., Sadzot-Delvaux, C., Rentier, B., & Gershon, A. (2007). Increasing coverage and
efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in
Europe : A role for the combined vaccine. Pediatric Infectious Disease Journal, 26(7), 632-638.
http://hdl.handle.net/2268/1384
• Di Valentin, E., Bontems, S., Habran, L., Jolois, O., Markine-Goriaynoff, N., Vanderplasschen, A.,
Sadzot, C., & Piette, J. (2005). Varicella-zoster virus IE63 protein represses the basal transcription
machinery by disorganizing the pre-initiation complex. Biological Chemistry, 386(3), 255-267.
• Cohen, J. I., Krogmann, T., Bontems, S., Sadzot-Delvaux, C., & Pesnicak, L. (2005). Regions of the
varicella-zoster virus open reading frame 63 latency-associated protein important for replication in vitro
are also critical for efficient establishment of latency. Journal of Virology, 79(8), 5069-77.
• Habran, L., Bontems, S., Di Valentin, E., Sadzot-Delvaux, C., & Piette, J. (2005). Varicella-zoster
virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its
cellular localization and activity. Journal of Biological Chemistry, 280(32), 29135-43.
• Grinfeld, E., Sadzot-Delvaux, C., & Kennedy, P. G. E. (2004). Varicella-Zoster virus proteins encoded
by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat
model. Virology, 323(1), 85-90.
• Nikkels, A., Simonart, T., Kentos, A., Liesnard, C., Sadzot-Delvaux, C., Feremans, W., & Pierard, G.
(2003). Atypical recurrent varicella in 4 patients with hemopathies. Journal of the American Academy
of Dermatology, 48(3), 442-7.
• Bontems, S., Di Valentin, E., Baudoux, L., Rentier, B., Sadzot-Delvaux, C., & Piette, J. (2002).
Phosphorylation of varicella- zoster virus IE63 protein by casein kinases influences its cellular
localization and gene regulation activity. Journal of Biological Chemistry, 277(23), 21050-21060.
http://hdl.handle.net/2268/5176
• Stouvenakers, N., Sadzot-Delvaux, C., & Rentier, B. (2001). Current issues : varicella. Vaccines :
Children and Practice, 4,
• Nikkels, A., Sadzot-Delvaux, C., Rentier, B., Pierard-Franchimont, C., & Pierard, G. (1998). Lowproductive alpha- herpesviridae infection in chronic lichenoid dermatoses. Dermatology : International
Journal for Clinical & Investigative Dermatology, 196(4), 442-446.
• Piette, J., Defechereux-Thibaut de Maisières, P., Baudoux-Tebache, L., Sadzot-Delvaux, C., &
Rentier, B. (1998). La régulation des cycles infectieux du virus de la varicelle et du zona. M SMédecine Sciences, 14(5), 556-565.
• Rentier, B., Piette, J., Baudoux, L., Debrus, S., Defechereux, P., Merville, M.-P., Sadzot-Delvaux, C.,
& Schoonbroodt, S. (1996). Lessons to be learned from varicella-zoster virus. Veterinary Microbiology,
53(1-2), 55-66.
• Nikkels, A., Delvenne, P., Sadzot-Delvaux, C., Debrus, S., Piette, J., Rentier, B., Lipcsei, G.,
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Quatresooz, P., & Pierard, G. (1996). Distribution of varicella-zoster virus and herpes simplex virus in
disseminated fatal infections. Journal of Clinical Pathology, 49(3), 243-248.
http://hdl.handle.net/2268/7664
• Nikkels, A., Delvenne, P., Debrus, S., Sadzot-Delvaux, C., Piette, J., Rentier, B., & Pierard, G. (1995).
Distribution of varicella- zoster virus gpI and gpII and corresponding genome sequences in the skin.
Journal of Medical Virology, 46(2), 91-96
• Debrus, S., Sadzot-Delvaux, C., Nikkels, A., Piette, J., & Rentier, B. (1995). Varicella-zoster virus
gene 63 encodes an immediate-early protein that is abundantly expressed during latency. Journal of
Virology, 69(5), 3240-3245.
• Nikkels, A., Debrus, S., Sadzot-Delvaux, C., Piette, J., Rentier, B., & Pierard, G. (1995).
Immunohistochemical identification of varicella-zoster virus gene 63-encoded protein (IE63) and late
(gE) protein on smears and cutaneous biopsies: implications for diagnostic use. Journal of Medical
Virology, 47(4), 342-7.
• Nikkels, A., Debrus, S., Sadzot-Delvaux, C., Piette, J., Rentier, B., & Pierard, G. (1995). Localization
of varicella-zoster virus nucleic acids and proteins in human skin. Neurology, 45(12 Suppl 8), 47-9.
• Nikkels, A., Debrus, S., Delvenne, P., Sadzot-Delvaux, C., Piette, J., Rentier, B., & Pierard, G. (1994).
Viral glycoproteins in herpesviridae granulomas. American Journal of Dermatopathology, 16(6), 588592.
• Nikkels, A., Delvenne, P., Sadzot-Delvaux, C., Quatresooz, P., Boniver, J., Rentier, B., & Pierard, G.
(1994). Varicelle létale. Etude immunohistochimique et par hybridation in situ. Annales de
Dermatologie et de Vénéréologie, 121(2), 113-117.
• Snoeck, R., Andrei, G., Gerard, M.-C., Silverman, A., Hedderman, A., Balzarini, J., Sadzot-Delvaux,
C., Tricot, G., Clumeck, N., & De Clercq, E. (1994). Successful treatment of progressive
mucocutaneous infection due to acyclovir- and foscarnet- resistant herpes simplex virus with (S)-1-(3hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Clinical Infectious Diseases : An Official
Publication of the Infectious Diseases Society of America, 18(4), 570-8.
• Snoeck, R., Gérard, M., Sadzot-Delvaux, C., Andrei, G., Balzarini, J., Reymen, D., Ahadi, N.,
Debruyn, J. M., Piette, J., Rentier, B., Clumeck, N., & De Clercq, E. (1994). Meningoradiculoneuritis
due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient.
Journal of Medical Virology, 42(4), 338-347.
• Nikkels, A., Debrus, S., Sadzot-Delvaux, C., Piette, J., Delvenne, P., Rentier, B., & Pierard, G. (1993).
Comparative immunohistochemical study of herpes-simplex and varicella-zoster infections. Virchows
Archiv. A : Pathological Anatomy and Histopathology, 422(2), 121-126. http://hdl.handle.net/2268/6318
• Moonen, G., Delrée, P., Martin, D., Sadzot-Delvaux, C., & Schoenen, J. (1993). Neurotransmitter
phenotype plasticity in adult dorsal root ganglia neurons. Restorative Neurology & Neuroscience, 5,
48.
• Rogister, B., Delrée, P., Leprince, P., Martin, D., Sadzot-Delvaux, C., Malgrange, B., Munaut, C.,
Rigo, J. M., Lefebvre, P. P., Octave, J. N., Schoenen, J., & Moonen, G. (1993). Transforming growth
factor ß as a neuronoglial signal during peripheral nervous sytem response to injury. Journal of
Neuroscience Research, 34, 32-43.
• Snoeck, R., Gerard, M., Sadzot-Delvaux, C., Andrei, G., Balzarini, J., Reymen, D., Piette, J., Rentier,
B., Clumeck, N., & De Clercq, E. (1993). Meningoradiculoneuritis due to acyclovir-resistant varicellazoster virus in a patient with aids. Journal of Infectious Diseases, 168(5), 1330-1331.
• Delree, P., Martin, D., Sadzot-Delvaux, C., Rogister, B., Leprince, P., Robe, P., Rigo, J.-M., Lefebvre,
P. P., Malgrange, B., Schoenen, J., & Moonen, G. (1992). In Vitro and in Vivo Modulation of 5Hydroxytryptamine-, Thyrotropin-Releasing Hormone- and Calcitonin-Gene Related Peptide-Like
Immunoreactivities in Adult Rat Sensory Neurons. Neuroscience, 51(2), 401-10.
• Snoeck, R., Schols, D., Sadzot-Delvaux, C., Cloes, J.-M., Andrei, G., De Clercq, E., Piette, J., &
Rentier, B. (1992). Flow cytometric method for the detection of gpI antigens of varicella zoster virus
and evaluation of anti-VZV agents. Journal of Virological Methods, 38(2), 243-254.
• Piette, J., Defechereux, P., Baudoux, L., Melen-Lamalle, L., Debrus, S., Sadzot-Delvaux, C., Merville,
M.-P., & Rentier, B.
(1992). La régulation de l'expression des gènes du virus de la varicelle et du zona. Annales de
Médecine Vétérinaire, 136(8), 627-635
• Bourdon-Wouters, C., Merville, M.-P., Sadzot-Delvaux, C., Marc, P., Piette, J., Delrée, P., Moonen,
G., & Rentier, B. (1990). Acute and persistent varicella-zoster virus infection of human and murine
neuroblastoma cell lines. Journal of Neuroscience Research, 26(1), 90-97.
• Merville-Louis, M. P., Sadzot-Delvaux, C., Delree, P., Piette, J., Moonen, G., & Rentier, B. (1989).
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Catherine SADZOT
Varicella-zoster virus infection of adult rat sensory neurons in vitro. Journal of Virology, 63(7), 3155-60.
6. Book chapters
• Fillet, A. M., Sadzot-Delvaux, C., & Rentier, B. (2003). Virus Varicelle-Zona. In J.-M., Huraux, J.-C.,
Nicolas, H., Agut, & H., Peigue-Lafeuille (Eds.), Virologie médicale (pp. 179-193). Paris, France:
Estem ; Agence universitaire de la francophonie.
• Sadzot-Delvaux, C., & Rentier, B. (2001). The role of varicella zoster virus immediate-early proteins
in latency and their potential use as components of vaccines. In A. A., Gershon, C. H., Calisher, & A.
M., Arvin (Eds.), Immunity to and Prevention of Herpes Zoster (pp. 81-89). Springer.
http://hdl.handle.net/2268/4166
• Sadzot-Delvaux, C., & Rentier, B. (2000). Animal models of VZV infection. In A. A., Gershon & A. M.,
Arvin (Ed.), Varicella- Zoster Virus : Virological and Clinical Management (pp. 169-184). Cambridge:
Cambridge University Press.
• Sadzot-Delvaux, C., Baudoux, L., Defechereux, P., Piette, J., & Rentier, B. (1999). Overview of the
replication cycle of varicella-zoster virus. In A., Schmidt, M. H., Wolff, & S., Schünemann (Eds.),
Varicella-Zoster Virus : Molecular Biology, Pathogenesis and Clinical Aspects (pp. 21-42). Karger.
Projects
The main projects led in my group are (or have been) summarized as follows:
- In vivo and in vitro models of Varicella Zoster infection
- Characterization of the adaptative immune response to VZV IE63
- Modulation of the innate immune reponse by VZV
- Characterization of VZV proteins: IE4, IE62, IE63, ORF9p
Currently:
- Mechanisms of primary eand secondary envelopment of VZV
Memberships
2000-2004: member of EUROVAR (European Working Group on varicella vaccination)
2004-2009: member of W.A.V.E (Working Against Varicella in Europe)
Other Relevant Information
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