Dr.med. Anis Feki MD, PhD

Dr.med. Anis Feki MD, PhD
Department of Obstetrics and Gynecology
Hôpital Cantonal Fribourgeois
Case postale
1708 Fribourg
Home:
4, route de Genolier
1266 Duillier
Curriculum vitae
1.
PERSONAL DATA
th
Born the 30 May 1970
Nationality: Swiss
Married and two children.
Languages written and spoken: French, Italian, German, English, and Arabic
2.
PRESENT POSITION
Head of the Department of obstetrics and gynecology. Hopital cantonal fribourgeois. Switzerland.
Director of the Stem Cell Research Laboratory. Geneva University Hospital. Switzerland
3.
DIPLOMAS:
1988
1992
1999
2000
2000
Baccalaureate with honors
M.SC in physics. Canada
MD in medicine with honors. Tunis Faculty of Medicine. Tunisia
Title: The importance of thoracic surgery in multi-drug resistant tuberculosis
Swiss equivalence of the MD degree
Diploma of Specialization in Reproductive Medicine and Reproductive Biology. Faculty of
Medicine, Geneva University
2002
Diploma of Specialization in Medical Biology. Faculty of Sciences. Geneva University
2002
Certificate in Entrepreneurship. Geneva University & EPFL-Lausanne
2004
MD in medicine with the price of the best medical thesis. Faculty of medicine. Geneva
University
Title: The role of BARD1 in tumor suppression in an animal cancer model.
Thesis director: professor Karl-Heinz Krause
PhD in Biology. Faculty of Sciences, Geneva University
Molecular characterization of the tumor suppressor gene BARD1 in development and tumor
suppression.
Thesis director: professors Karl-Heinz Krause and Ueli Schibler
FMH in obstetrics and gynecology
FMH in operative obstetrics and gynecology
FMH in reproductive medicine and in gynecologic endocrinology
2004
2010
4.
PROFESSIONAL ACTIVITIES (POST-GRADUATE)
April 2011
2010-2011
2007-2010
2005-2007
2004-2005
2000 - 2004
2000
Chef de clinique. Reproductive medicine and endocrinology unit. Service of gynecology.
Department of obstetrics and gynecology. Geneva University Hospitals. Switzerland
Fellowship and consultant in Reproductive medicine unit. Service of gynecology. Catholic
University of Louvain. Brussels. Belgium
Chef de clinique. Reproductive medicine and endocrinology unit. Service of gynecology.
Department of obstetrics and gynecology. Geneva University Hospitals. Switzerland
Resident in the service of gynecology. Department of obstetrics and gynecology. Geneva
University Hospitals. Switzerland
Resident in the service of obstetrics. Department of obstetrics and gynecology. Geneva
University Hospitals. Switzerland
Resident, Biology of Aging Laboratory: Geriatric department. Geneva University Hospitals.
Switzerland
Resident, Department of obstetrics and gynecology. Geneva University Hospitals.
Switzerland
1999
Resident, Department of obstetrics and gynecology, Tunisia
1998
Resident, Department of thoracic surgery. Tunisia
1998
Resident, Department of pediatrics. Tunisia
1997
Resident, Department Resuscitation. Tunisia
1997
Resident, Department of psychiatry. Tunisia
1996
Resident, Department of surgical oncology. Tunisia
5.
RESEARCH
Novel approaches for the derivation of human embryonic stem cells: animal-free conditions, maintenance of
pluripotency, and clonal expansion.
Clinical grade iPS generation: genetic stability, pluripotency and self-renew analysis
6.
TEACHING
2006-2007
2007-2008
2008-2009
2009-2010
2010-2011
7.
HONOURS AND AWARDS
2001
2004
2008
8.
Pre-graduate teaching (APP). 32 hours per year. Geneva Faculty of Medicine. Switzerland
Pre-graduate teaching (APP). 32 hours per year. Geneva Faculty of Medicine. Switzerland
Graduate teaching (AMC). 24 hours per year. Geneva Faculty of Medicine. Switzerland
Graduate teaching (AMC). 24 hours per year. Geneva Faculty of Medicine. Switzerland
Graduate teaching (AMC). 24 hours per year. Geneva Faculty of Medicine. Switzerland
The American Association for Cancer Research Pezcoller Foundation Scholar in Training
Award
Geneva Faculty of Medicine price for the best thesis
Bayer-Schering award of the Swiss Society of Obstetrics and Gynecology
PROFESSIONAL SOCIETIES
Member of the American Association for Cancer Research (AACR)
Member of the American Society of Clinical Oncology (ASCO)
Member of the Swiss MD-PhD Association (SMPA)
Board Executive Member of the European Society of Human Reproduction and Embryology (ESHRE)
SIG deputy member of ESHRE
Member of the International Society of Stem Cell Research (ISSCR)
9.
OFFICIAL POSTS
President of the Association des Médecins Assistants en Recherche (AMIR)
Ad hoc reviewer for research articles in New England Journal of Medicine, International Journal of Biochemistry
and Cell Biology, Neuro-urology and Urodynamics journal, Pathobiology journal, Stem Cells, Stem Cell &
Development, Human Reproduction, e-Cells and Materials Journal, Stem Cell Research, Journal of Cellular
Biochemistry and Biotechnology Progress, PLoS One.
10. GRANTS
January 2006- December 2008:
SCORE (Swiss Clinician Opting for Research) of the Swiss National Foundation grant:
SNF: 3232B0-111339/1: 368’784. - Sfr
SNF: 3200B0-111340/1: 400’000. – Sfr
January 2006- December 2006:
Research fund of the department of obstetrics and gynecology, Geneva University Hospital: 8’000. – Sfr
January 2007- December 2008:
Roche Research Foundation Subside: 32’750. - Sfr
Ernst & Lucie Schmidheiny Foundation Grant: 20’000. - Sfr
Bayer-Schering award of the Swiss Society of Obstetrics and Gynecology: 10’000. – Sfr
January 2008- December 2009:
Grant from the International Society of IVF & IVM: 20’000 $
April 2010- March 2012:
Grant from Genico SA: 276’000. – Sfr
November 2011-October 2012
Grant from Gertrude Von Meissner Foundation: 50’000. –Sfr
November 2011-October 2012
Grant from Dr Henri Dubois-Ferrière Dinu Lipatti Foundation: 80’000. –Sfr
November 2011-October 2012
Grant from the Ernest Boninchi Foundation: 72’000. –Sfr
11.
CONGRESSES, CONFERENCES
•
EOS/SPIE European Biomedical Optics Weeks – EbiOS. 2000
•
Meeting of the International Society of Fertility and Sterility. Edinburgh. 2000
•
Cancer detection and prevention Meeting, Geneva. 2001
•
92nd Annual meeting of the AACR, New Orleans. 2001.
•
XIXe Congrès de la Société d’Andrologie de Langue Française. SALF 2002, 12-14 December, Geneva
•
Cancer, Apoptosis and Aging workshop. Geneva. 2002.
•
6th interactive day between Geneva and Lausanne medicine Faculties. Changin. 2002.
•
3rd Joint meeting of the British Andrology Society, the British Fertility Society and the Society for
Reproduction and fertility. Aberdeen 2003
•
USGEB. Fribourg, 2004.
•
SGGO meeting. Lugano 2005
•
ESHRE meeting 2006, Prague July 3-4-5
•
Anti-Aging Medicine World Congress 2007, Monaco March 22-23-24
•
ESHRE meeting 2007, Lyon July 3-4-5
•
International Initiative for Stem Cell Research 2007, Bar Harbor October 18-19
•
Annual meeting of the Mediterranean Society of Reproductive Medicine 2008, Tunisia May 15-18
•
Annual meeting of the Middle East Fertility Society 2008, Tunisia October 15-18
•
15th World congress on IVF and IVM. Geneva, Switzerland, 19-22 April 2009.
•
6th International Stem Cell School in Regenerative Medicine 2009. Odense, Denmark, 14-16 June, 2009.
•
ESHRE annual meeting. Amsterdam, 28-1 july 2009.
•
ESHRE annual meeting. Rome, 27-30 June 2010.
•
2010 Advanced Course of Mastology. Mastology Association of the Northern and Southern Mediterranean.
Geneva 2010. Switzerland
•
The 20th STGO, 4th FGOM, and the 11th FEMGO joint meeting. 7 to 9th October 2010. Tunis. Tunisia
•
29ème Congrès National de la SRMGO. 4 - 5 Février 2011 Hôtel Sheraton. Casablanca. Marocco
•
The Gyn2011 congress. 9-11 June 2011. Monaco
•
Third Congress of the Society of Reproductive Medicine. Antalya, October 5th and 9th, 2011
•
Cell Symposia. Stem Cell Programming & Reprogramming. Lisbon, Portugal. December 8–10 2011.
12.
PUBLICATIONS
th
a.
Original articles published or accepted in peer reviewed journals:
•
Stefano Camnasio, Alessia Delli Carri, Angelo Lombardo, Iwona Grad, Caterina Mariotti, Alessia Castucci,
Björn Rozelle, Pietro Lo Riso, Valentina Castiglioni, Chiara Zuccato, Christelle Rochon, Cinzia Gellera, Marisa
Jaconi, Austin Smith, Outi Hovatta, Luigi Naldini, Stefano Di Donato, Anis Feki, Elena Cattaneo. Induced
pluripotent stem cells from patients with homozygous and heterozygous Huntington’s disease exhibit
enhanced lysosomal activity. Accepted in Neurobiology of Disease . (IF: 5.121)
•
The International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H,
Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D,
Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ,
Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM,
Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Guangxiu L, Hampl A, Harron K, Healy L,
Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S,
Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee
DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki
T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan
F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh
GH, Schulz TC, Sermon K, Mohamed JS, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey
GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y,
Oostwaard DW, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Screening ethnically diverse human
embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat
Biotechnol. 2011 Nov 27. doi: 10.1038/nbt.2051. (IF: 31.1)
•
Grad I, Hibaoui Y, Jaconi M, Chicha L, Bergström-Tengzelius R, Sailani MR, Pelte MF, Dahoun S, Mitsiadis TA,
Töhönen V, Bouillaguet S, Antonarakis SE, Zucchelli M, Hovatta O, Feki A. Nanog Priming Before Full
Reprogramming May Generate Germ Cell Tumors. Accepted in eCM journal. (IF: 9.650)
•
Fernández M, Pirondi S, Chen BL, Del Vecchio G, Alessandri M, Farnedi A, Pession A, Feki A, Jaconi ME, Calzà
L. Isolation of rat embryonic stem-like cells: A tool for stem cell research and drug discovery. Dev Dyn. 2011
Nov;240(11):2482-94. doi: 10.1002/dvdy.22761. (IF: 2.864)
•
Laurie Chicha, Anis Feki, Outi Hovatta, Olivier Irion, Marisa Jaconi. Human Embryonic and Induced Pluripotent
Stem Cells Differentiated in Fully Defined Medium Generate Hematopoietic CD34+ and CD34- Progenitors
with Distinct Characteristics. PLoS one. 2011 (IF: 4.351)
•
De Rosa A, Tirino V, Paino F, Tartaglione A, Mitsiadis T, Feki A, d'Aquino R, Laino L, Colacurci N, Papaccio G.
Amniotic fluid-derived MSCs lead to bone differentiation when co-cultured with dental pulp stem cells. Tissue
Eng Part A. 2010 Nov 22. (IF: 4.582)
•
Hovatta O, Jaconi M, Töhönen V, Béna F, Gimelli S, Bosman A, Holm F, Wyder S, Zdobnov EM, Irion O,
Andrews PW, Antonarakis SE, Zucchelli M, Kere J, Feki A. A teratocarcinoma-like human embryonic stem cell
(hESC) line and four hESC lines reveal potentially oncogenic genomic changes. PLoS one. 2010 Apr
23;5(4):e10263. (IF: 4.351)
•
Holm F, Ström S, Inzunza J, Baker D, Strömberg AM, Rozell B, Feki A, Bergström R, Hovatta O. An effective
serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent
stem cells. Hum Reprod. 2010 Mar 5. [Epub ahead of print]. (IF: 3.859)
•
Unger C, Gao S, Cohen M, Jaconi M, Bergstrom R, Holm F, Galan A, Sanchez E, Irion O, Dubuisson JB, GiryLaterriere M, Salmon P, Simon C, Hovatta O, Feki A. Immortalized human feeder cells which maintain human
embryonic stem cell pluripotency and the generation of induced pluripotent stem cells. Human reproduction.
2009 Jul 3. [Epub ahead of print]. (IF: 3.859)
•
Suter DM, Preynat-Seauve O, Tirefort D, Feki A, Krause KH. Phenazopyridine induces and synchronizes
neuronal differentiation of embryonic stem cells. J Cell Mol Med. 2009 Jan 16. (IF: 6.807)
•
Preynat-Seauve O, Suter DM, Tirefort D, Turchi L, Virolle T, Chneiweiss H, Foti M, Lobrinus JA, Stoppini L, Feki
A, Dubois-Dauphin M, Krause KH. Development of brain-like human tissue upon differentiation of embryonic
Stem cells in three dimensional culture. Stem Cells. 2008 Dec 11. (IF: 7.741)
•
Feki A, Bosman A, Dubuisson J-B, Irion O, Dahoun S, Pelte M-F, Hovatta O, and Jaconi M. Derivation of a
human embryonic stem cell line (hESC) from a single blastomere of an arrested four cell stage embryo. Swiss
Med Wkly. 2008 Sep 20;138(37-38):540-50. (IF: 1.681)
•
Cartier L, Laforge T, Feki A, Arnaudeau S, Dubois-Dauphin M, Krause KH. Pax6-induced alteration of cell fate:
Shape changes, expression of neuronal alpha tubulin, post mitotic phenotype, and cell migration. J Neurobiol.
2006 Jan 19 (IF: 4.209)
•
Feki A, Jefford CE, Krause KH, and Irminger-Finger I. BARD1 induces apoptosis by catalyzing phosphorylation
of p53 by DNA-damage response kinase. Oncogene. 2005 May 26;24(23):3726-36. (IF: 7.216)
•
Feki A, Jefford CE, Durand P, Harb J, Lukas H, Krause KH, Irminger-Finger I. BARD1 Expression During
Spermatogenesis Is Associated with Apoptosis and Hormonally Regulated. Biol Reprod. 2004 Nov;71(5):161424. (IF: 3.469)
•
Jefford CE, Feki A, Jean Harb, Krause KH, and Irminger-Finger I. Nuclear-cytoplasmic translocation of BARD1
is linked to its apoptotic activity. Oncogene. 2004 Apr 29;23(20):3509-20. (IF: 7.216)
•
Irminger-Finger I, Leung WC, Li J, Dubois-Dauphin M, Harb J, Feki A, Jefford CE, Soriano JV, Jaconi M,
Montessano R, Krause KH. Identification of BARD1 as mediator between proapoptotic stress and p53dependent apoptosis. Mol Cell. 2001 Dec;8(6):1255-66. (IF: 16.811)
•
Kulier R, Feki A, Hofmeyr GJ, Campana A. Surgical methods for first trimester termination of pregnancy.
Cochrane Database Syst Rev. 2001;(4):CD002900. (IF: 5.653)
b.
Reviews published or accepted in peer reviewed journals
•
Bergström R, Ström S, Holm F, Feki A, Hovatta O. Xeno-free culture of human pluripotent stem cells.
Methods Mol Biol. 2011;767:125-36.
•
Mitsiadis TA, Feki A, Papaccio G, Catón J. Stem cells, niches and Notch signaling during dental pulp
regeneration. Adv Dent Res. 2011 Jul;23(3):275-9. (IF: 3.458)
•
Na J, Plews J, Li J, Wongtrakoongate P, Tuuri T, Feki A, Andrews PW, Unger C. Molecular mechanisms of
pluripotency and reprogramming. Stem Cell Res Ther. 2010 Oct 25;1(4):33.
•
Preynat-Seauve O, Burkhard PR, Villard J, Zingg W, Ginovart N, Feki A, Dubois-Dauphin M, Hurst S, Mauron A,
Jaconi M, Krause KH. Pluripotent stem cells as new drugs? The example of Parkinson's disease. Int J Pharm.
2009 Nov 3;381(2):113-21. (IF: 3.061)
•
Feki A, Berardi P, Bellingan G, Major A, Krause KH, Petignat P, Zehra R, Pervaiz S, and Irminger-Finger I.
Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic
spreading in ovarian cancer model. Crit Rev Oncol Hematol. 2009 Oct;72(1):1-9. (IF: 4.632)
•
Feki A, Hovatta O, Jaconi M. Derivation of human embryonic stem cell lines from single cells of four cell stage
embryos – be aware of the risks. Hum Reprod. 2008 Dec;23(12):2874. (IF: 3.543)
•
Lei T, Jacob S, Agil-Zaraa I, Dubuisson JB, Irion O, Jaconi M and, Feki A. Human embryonic stem cells:
Challenges and limitations toward their clinical use. Cell Res. 2007 Aug;17(8):682-8. (IF: 8.151)
•
Feki A, Faltin DL, Dubuisson J-B, Jacob S, Irion O. Sphincter incontinence: Is regenerative medicine the best
alternative to restore urinary or anal sphincter function? Int J Biochem Cell Biol. 2006 Nov 7 (IF:4.804)
•
X lu, A Feki. Phenotipic Features with P53 Alterations Related to HPV and Prognostic Evaluation in Cervical
Cancer. Int J Gynecol Cancer. 2006 Mar-Apr; 16(2):708-17. (IF: 1.932)
•
Feki A, Irminger-Finger I. Mutational spectrum of p53 mutations in primary breast and ovarian tumors. Critical
reviews in Oncology / Hematology. 2004 Nov;52(2):103-16. (IF: 4.632)
c.
Editorials published or accepted non peer reviewed journals
•
Feki A, Fraisse T, Irion O, Dubuisson JB, Hovatta O. Preservation of women fertility facing potential
premature ovarian failure. Rev Med Suisse. 2008 Oct 22;4(176):2264-6, 2268.
•
D de Ziegler, N Vulliemoz, A Feki, V Ibecheole, P Ventura. Reproductive endocrinology and infertility in the
light of 20 years of IVF experience. Rev Med Suisse. 2006 Feb 15; 2(53):438-40, 442.
•
M Jaconi and A Feki. La nouvelle loi sur les cellules souches embryonnaires: un an après. Swiss Medical
Forum. 2005; 5:1247-8.
d.
•
Chapter book
Xeno-Free Culture of Human Pluripotent Stem Cells. Rosita Bergström, Susanne Ström, Frida Holm, Anis Feki,
and Outi Hovatta. Human Pluripotent Stem Cells. Methods and Protocols. Series: Methods in Molecular
Biology, Vol. 767. Schwartz, Philip H.; Wesselschmidt, Robin (Eds.). 1st Edition., 2011, 425 p. 92. ISBN: 978-161779-200-7
e.
Editorials submitted in peer reviewed journals
•
Amiq Gazdhar, Iwona Grad, Mathias Gugger, Anis Feki, Thomas Geiser. iPS cells attenuate bleomycin induced
lung injury in the rat lung. Submitted
•
C. Pirard, A. Feki, J. Donnez, and E. Loumaye. GnRH agonist – New approach to the luteal phase: Rationale
and clinical data on patient convenience. Submitted
•
C. Pirard, A. Feki, J. Donnez, and E. Loumaye. A patient-friendly ART treatment using GnRH agonist as luteal
phase support improved implantation: a prospective, randomized, comparative study. Submitted
•
Hibaoui Y, Grad I, Vianin S, Bosman A, Borel C, Jaconi M, Antonarakis SE, Feki A. Ectoderm defect in iPS cell
derived from fibroblasts of Monozygotic twins discordant for trisomy 21.
f.
Abstracts presented at international meetings
•
Fekih A, Farah N, Chardonnens D, Urner F, De Ziegler D, Bianchi PG, Mock P, Campana A & Lucas H. Failed
oocyte maturation in vitro. Journal of Reproduction and Fertility. 2000.
•
Fekih A, Major A, Lüdicke F, Campana A, Irminger-Finger I: Molecular characterization of apoptotic pathway
induced by PDT. EOS/SPIE European Biomedical Optics Weeks – EbiOS . 2000
•
A. Feki, Frank Lüdicke, Jian Li, Karl-Heinz Krause, Attila Major, Irmgard Irminger-Finger. Analysis of tumor
suppressor function of BARD1 (BRCA1 associated Ring domain protein) in a rat ovarian cancer model. Proc.
Amer. Assoc. Can. Res. 2001. 42,420.
•
A. Feki, A. Major, F. Lüdicke, C. E. Jefford, A. Campana, and I. Irminger. Molecular characterization of
apoptotic pathway induced by PDT: implication of tumor suppressor genes prospective markers. Cancer
detection and prevention.2001. 24: S68.
•
A. Feki, C. E. Jefford, M. Dubois-Dauphin, I. Irminger. Mechanism of apoptotic signaling by tumor suppressor
BARD1. International J. of Mol. Medicine.2001. 8: 432.
•
A. Feki, C.E. Jefford, J. Harb, M. Dunois-Dauphin, I. Irminger-Finger. The role of tumor suppressor BARD1 in
cell death and life. Proc. Amer. Assoc. Can. Res. 2002. 43: 988.
•
I. Irminger-Finger, A. Meisser, M. Hardy Sow, A. Feki, and Paul Bischof. Immunolocalization of BARD1 (BRCA1
Associated Ring Domain Protein 1) in early pregnancy trophoblast. Placenta. 2003. 24: A.26
•
A. Feki, C-E. Jefford, L. Cartier, A. Major, K-H. Krause and I. Irminger. Implication of BARD1 in tumor
suppression and response to therapy: monitoring of tumor growth and regression by photomedicine and
GFP-tagging. The Pezcoller Foundation Journal. 2003. 20:29
•
Elbarbary TM, Lucas H, Urner F, De Vantery C, F Pelte, Feki A, De Agostini A, and Chardonnens D.
Spontaneous pregnancy after ovarian tissue cryopreservation by vitrification and intra-uterine
transplantation. Reproduction. 2003. 30:82
•
Jefford CE, A. Feki, K-H. Krause, and I. Irminger. Role of tumor suppressor BARD1 in control of cell
proliferation in development and malignant transformation. 8th Congress on Advances in Oncology & 6th
International Symposium on Molecular Medicine. Greece, 2003.
•
A. Feki, C-E. Jefford, L. Cartier, K-H. Krause and I. Irminger-Finger. Role of tumor suppressor BARD1 and
malignant transformation. Cell and Molecular Biology of Cancer Meeting, Lausanne. January 2003
•
Feki A, Jefford CE, Durand P, Lucas H, Chardonnens D, Krause KH, and Irminger I. The role of a tumor
suppressor gene BARD1 and its spliced variant in spermatogenesis. Reproduction. 2003. 30: 34
•
A. Feki, C-E. Jefford and I. Irminger. Role of tumor suppressor BARD1 in development and malignant
transformation; implications for therapeutic interventions. New Insight in Molecular Diagnosis and Therapy.
Paris, January 2004.
•
D. de Ziegler, R. Uras, N. Vuillemoz, A. Feki, M. Yaron, V. Ibecheole. Endometriosis and IVF: to perform
surgery or not? European meeting in reproduction medicine. Turkey 2005.
•
S Ryser, A Feki, Ph Durand, Ph Tacchini, I Irminger-Finger. Identification of stem cell markers and potent
testis-tumoral markers by expression profiling in male germinal stem cell. ELSO meeting, Dresden, Germany
2005.
•
Jian-Yu Wu, Anis Feki, Charles Edward Efford and Irmgard Irminger-Finger. Role of tumor suppressor BARD1
in malignant transformation: Implications for therapeutic interventions. Proc Amer Assoc Cancer Res, Volume
46, 2005
•
Stephan Ryser, Anis Feki, Philippe Durand, Philippe Tacchini and Irmgard Irminger-Finger. Identification of
stem cell markers and potent testis-tumoral markers by expression profiling in male germinal stem cell. Proc
Amer Assoc Cancer Res, Volume 46, 2005
•
Feki A. Derivation of human embryonic stem cell line from single blastomere of an arrested four-cell stage
embryo. MEFS 2008
•
Feki A. Challenges toward the use of human embryonic stem cells and induced pluripotent stem cells in
regenerative medicine. MEFS 2008
•
Christelle Rochon, Valentina Castiglioni, Alessia Delli Carri, Luciano Conti, Caterina Mariotti, Stefano
DiDonato, Marisa Jaconi, Outi Hovatta, Anis Feki, Elena Cattaneo. GENERATION OF iPS CELLS FOR
MECHANISTICS STUDIES IN HUNTINGTON'S DISEASE. IV Meeting on the MOLECULAR MECHANISMS OF
NEURODEGENERATION. May 8-10, 2009. Milano, Italy
•
Audrey Letourneau, Stephen B. Montgomery, David Gonzalez, Daniel Robyr, Christelle Borel, Eugenia
Migliavacca, Youssef Hibaoui, Laurent Farinelli, Maryline Gagnebin, Emilie Falconnet, Samuel Deutsch, Sophie
Dahoun-Hadorn, Jean-Louis Blouin, Anis Feki, Roderic Guigo, Emmanouil T. Dermitzakis, Stylianos E.
Antonarakis. Trisomy 21: a disease of chromatin architecture? The American Society of Human Genetics
annual meeting 2011.
•
Yaron M, Beck-Popovic M, Girardin C, Phan-Hug F, Wunder D, Primi MP, Feki A, Ibecheole V, Simon JP,
Schwitzgebel V, Turello R, Bellavia M, Ambrosetti A, Gumy-Pause F. Fertility preservation in female pediatric
cancer patients, a multidisciplinary approach. Société suisse de pédiatrie + Société suisse de chirurgie
pédiatrique, Assemblée annuelle commune. Montreux, septembre 2011. Swiss Med Wkly, vol. 141 (2011), Suppl.
No 187, p. 41S
g.
Posters presented at international meetings
•
Fekih A, Major A, Lüdicke F, Campana A, Irminger-Finger I: Molecular characterization of apoptotic pathway
induced by PDT. EOS/SPIE European Biomedical Optics Weeks – EbiOS . Amsterdam. 2000
•
Fekih A, Farah N, Chardonnens D, Urner F, De Ziegler D, Bianchi PG, Mock P, Campana A & Lucas H. Failed
oocyte maturation in vitro. Meeting of the International Society of Fertility and Sterility. Edinburgh. 2000.
•
A. Feki, A. Major, F. Lüdicke, C. E. Jefford, A. Campana, and I. Irminger. Molecular characterization of
apoptotic pathway induced by PDT: implication of tumor suppressor genes prospective markers. Cancer
detection and prevention Meeting, Geneva. 2001.
•
Anis Feki, Frank Lüdicke, Jian Li, Karl-Heinz Krause, Attila Major, Irmgard Irminger-Finger. Analysis of tumor
nd
suppressor function of BARD1 (BRCA1 associated Ring domain protein) in a rat ovarian cancer model. 92
Annual meeting of the AACR, New Orleans. 2001.
•
C. E. Jefford, A. Feki, K-H. Krause and I. Irminger-Finger. Structure function studies on BARD1. 3rd
Breakthrough Conference on the functions of BRCA1 and 2. Cambridge. 2001.
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C. E. Jefford, A. Feki, K-H. Krause and I. Irminger-Finger. BRCA1-associated protein BARD1 responds to stress
by mediating p53-dependent apoptosis. Functional Genomics of Aging, Sevilla. 2002
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A. Feki, C.E. Jefford, J. Harb, M. Dunois-Dauphin, I. Irminger-Finger. The role of tumor suppressor BARD1 in
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cell death and life. 93 Annual meeting of the AACR, San Francisco. 2002.
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Elbarbary TM, Lucas H, Urner F, De Vantery C, F Pelte, Feki A, De Agostini A, and Chardonnens D.
Spontaneous pregnancy after ovarian tissue cryopreservation by vitrification and intra-uterine
transplantation. 3rd Joint meeting of the British Andrology Society, the British Fertility Society and the
Society for Reproduction and fertility. Aberdeen 2003
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Jefford CE, A. Feki, K-H. Krause, and I. Irminger. Role of tumor suppressor BARD1 in control of cell
proliferation in development and malignant transformation. 8th Congress on Advances in Oncology & 6th
International Symposium on Molecular Medicine. Greece, 2003.
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A. Feki, C-E. Jefford, and I. Irminger. Role of tumor suppressor BARD1 in development and malignant
transformation; implications for therapeutic interventions. New Insight in Molecular Diagnosis and Therapy.
Paris, January 2004.
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Christelle Rochon, Valentina Castiglioni, Alessia Delli Carri, Luciano Conti, Caterina Mariotti, Stefano
DiDonato, Marisa Jaconi, Outi Hovatta, Anis Feki, Elena Cattaneo. GENERATION OF iPS CELLS FOR
MECHANISTICS STUDIES IN HUNTINGTON'S DISEASE. IV Meeting on the MOLECULAR MECHANISMS OF
NEURODEGENERATION. May 8-10, 2009. Milano, Italy
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Unger Christian, Plews Jordan, Na Jie, Feki Anis, Andrews Peter W. RELATIVE QUANTIFICATION OF
TRANSCRIPTION FACTORS DURING THE PRODUCTION AND DIFFERENTIATION OF PLURIPOTENT STEM
CELLS. ISSCR, Barcelona 2009.
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Y Hibaoui, I Grad, MR Sailani, A Letourneau, S Dahoun, MF Pelte, F Béna, SE Antonarakis, A Feki. Modelling
neurogenesis impairment in Down syndrome disease using induced pluripotent stem cells derived from
human monozygotic twins discordant for trisomy 21. Cell Symposia. Stem Cell Programming &
Reprogramming. Lisbon, Portugal. December 8–10 2011,
h.
Abstracts presented at national meetings
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A. Feki, C-E. Jefford, A. Major, K-H. Krause, and I. Irminger. Cancer cell killing through proapoptotic tumor
suppressor function of BARD1 in rat ovarian cancer model. USGEB. Fribourg, 2004.
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C-E. Jefford, A. Feki, S. Gargos, I. Bondarev, F. Calabria, S. Chang, I. Irminger-Finger. In vitro repression of
BARD1 allows cells with critically short telomeres to pass M1 crisis. USGEB 2004
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Feki A, Faltin D, Vlastos AT, Vlastos G, Irion O, Irminger-Finger I. Role of Tumor Suppressor BARD1 in
Malignant Transformation; Implication for Therapeutic Interventions. Gynäkol Geburtshilfliche Rundsch
2005;45:175-76.
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Irminger-Finger I, Vlastos AT, Vlastos G, Feki A. P53 as a Prognostic Factor in Primary Breast and Ovarian
Tumors: Analysis of Published Clinical Data. Gynäkol Geburtshilfliche Rundsch 2005;45:191.
i.
Posters presented at national meetings
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T. Elbarbary, F. Urner , D. Chardonnens, A Feki, H.Lucas. Ovarian tissue cryopreservation. 6
between Geneva and Lausanne medicine Faculties. Changin. 2002.
interactive day
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A. Feki, C-E. Jefford, L. Cartier, K-H. Krause and I. Irminger-Finger. Role of tumor suppressor BARD1 and
malignant transformation. Cell and Molecular Biology of Cancer Meeting, Lausanne. January 2003
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A. Feki, C-E. Jefford, A. Major, K-H. Krause and I. Irminger. Cancer cell killing through proapoptotic tumor
suppressor function of BARD1 in rat ovarian cancer model. USGEB. Fribourg, 2004.
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C-E. Jefford, A. Feki, S. Gargos, I. Bondarev, F. Calabria, S. Chang, I. Irminger-Finger. In vitro repression of
BARD1 allows cells with critically short telomeres to pass M1 crisis. USGEB 2004.
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I Irminger Finger, A-T. Vlastos, G. Vlastos, A. Feki. P53 as a prognostic factor in primary breast and ovarian
tumorsa: Analysis of published clinical data. SGGO meeting. Lugano 2005
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Jungo Nançoz C, Dällenbach P, Vlastos G, Monnier S, Feki A, Dubuisson JB. From Surgical Pregnancy
Termination to Uterine Perforation. SSGO meeting. Interlaken 2010
j.
Oral presentations
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EOS/SPIE European Biomedical Optics Weeks – EbiOS. Molecular characterization of apoptotic pathway
induced by PDT. Amsterdam. 2000
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Cancer, Apoptosis and Aging workshop. The role of BARD1 in spermatogenesis. Geneva. 2002.
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XIXe Congrès de la Société d’Andrologie de Langue Française. BARD1 and testicular apoptosis. SALF 2002,
12-14 December, Geneva.
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Feki A, Jefford CE, Durand P, Lucas H, Chardonnens D, Krause KH, and Irminger I. The role of a tumor
suppressor gene BARD1 and its spliced variant in spermatogenesis. Aberdeen. 2003. Presentation selected
for the best young scientist.
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Feki A, D. Faltin, A-T. Vlastos, G. Vlastos, O. Irion, I. Irminger Finger. The role of BARD1 in malignant
transformation; implication for therapeutic interventions. SGGO meeting. Lugano 2005
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Feki A. The potential role of embryonic stem cells in regenerative medicine. Anti-Aging Medicine World
Congress 2007, Monaco March 22-23-24
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Feki A, Embryonic stem cell research: Quo vadis. Forum medical de la faculté de medicine de Sfax 2008,
Tunisia April 17-18
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Feki A. Derivation of human embryonic stem cell line from single blastomere of an arrested four-cell stage
embryo. MEFS 2008
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Feki A. Challenges toward the use of human embryonic stem cells and induced pluripotent stem cells in
regenerative medicine. MEFS 2008
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Feki A. PROMISES AND CHALLENGES TOWARDS THE CLINICAL USE OF PLURIPOTENT STEM CELLS. 15th
World congress on IVF and IVM. Geneva, Switzerland, 19-22 April 2009.
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Feki A. Derivation methods and characterisation of hESC. 6th International Stem Cell School in Regenerative
Medicine 2009. Odense, Denmark, 14-16 June, 2009.
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Feki A. Potential and drawbacks of pluripotent stem cells toward their clinical use. 6th International Stem Cell
School in Regenerative Medicine 2009. Odense, Denmark, 14-16 June, 2009.
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Feki A. In vitro reprogramming of fibroblasts into pluripotent E-cell like state: epigenetic remodeling and
tissue contribution. ESHRE annual meeting. Amsterdam, 28-1 july 2009.
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Feki A. Stem cells: State of the art. Meeting Internatzionale Ostetrico Neonatologico. September 16-18. Cuneo,
Italy
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Feki A. After reprogramming: cloning is still fiction? 2nd Congress of Society of Reproductive Medicine. 1 – 4
October, 2009. Gloria Golf Resort, Antalya, Turkey
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Feki A. Pluripotent stem cells and reproductive medicine. Advances in REI & ART meeting. McGill. Montreal
2009. Canada
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Feki A. Monnier S, Dubuisson JB, Vlastos G. Stem cells and breast cancer: dream or reality? Manosmed
course. Geneva 2010.
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Feki A. Dubuisson JB. Germ cells derived pluripotent stem cells: is it a fiction? The 20 STGO, 4 FGOM, and
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the 11 FEMGO joint meeting. 7 to 9 October 2010. Tunis. Tunisia
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Feki A. Cryo-préservation and transplantation of ovarian tissue. 29ème Congrès National de la SRMGO. 4 5 Février 2011 Hôtel Sheraton. Casablanca. Marocco
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Feki A. Stem cells and reproduction medicine. 29ème Congrès National de la SRMGO. 4 - 5 Février 2011
Hôtel Sheraton. Casablanca. Marocco
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Feki A. Understanding the oncogenetic potential of pluripotent stem cells. CIPF Fridays. February 2011.
Valencia. Spain
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Feki A. Cancer stem cells as a target for future therapies: Science or fiction? GYN2011. 9-11 Juin. Monaco.
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Feki A. Pluripotent stem cells and disease model. GYN2011. 9-11 Juin. Monaco.
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Feki A. A patient-friendly ART treatment using GnRH agonists as luteal phase support improved
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implantation. Third Congress of the Society of Reproductive Medicine. Antalya, October 5 and 9 , 2011
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Feki A. Pluripotent stem cells and germ cell differentiation in vitro. Third Congress of the Society of
Reproductive Medicine. Antalya, October 5th and 9th, 2011
Anis Feki MD, PhD