INS ASM 2013 programme - University of Limerick
Transcription
INS ASM 2013 programme - University of Limerick
University Hospitals Limerick (UHL) Annual Research Symposium 2015 Friday October 09th, 2015 Strand Hotel, Limerick Ireland Welcome! On behalf of the Organising Committee, it gives me great pleasure once again to welcome you to the 2015 University Hospitals Limerick Annual Research Symposium at the Strand Hotel, Limerick. This is our third major symposium and follows on from very successful scientific meetings in 2013 and 2014. Importantly, it demonstrates the continued growth in research capability and diversity across our Hospital network and University departments. We have had an enthusiastic response from our research community with over 190 scientific abstracts including 18 oral presentations. The Scientific Committee has taken great care in preparing a highquality and varied programme that will feature the latest developments and ideas in Health Services & Population Health, Lifestyle & Health, Technology & Health and Clinical Research. Poster presentations will be set up by 9.00am on Friday morning and on view until 5pm. Authors are requested to be present at their posters during the lunch and coffee breaks so please take time to view and discuss their work. We have an exciting line up of invited national and international speakers along with a welcoming address from Professor Don Barry, President of University of Limerick. Our aim this year is to further exploit our potential as an academic institution and highlight our recent research accomplishments. Finally, we are very grateful to our very generous sponsors whose continued support has made this meeting possible. We hope that you enjoy the meeting and look forward to meeting you on the day! Professor Austin Stack, Chair Organising Committee University Hospitals (UL) Limerick Annual Research Symposium Friday 09th October 2015 08.00am 08.45am- 9.00am Poster & Stand set-up----------- Coffee & Registration Welcome Address Professor Austin Stack Foundation Chair of Medicine, Graduate Entry Medical School, University Of Limerick & Professor Don Barry President, University Of Limerick Session 1 9:00am – 11:10am Invited Speaker (IRE) Chair: Professor Austin Stack 09.00am–09.45am “Research, Knowledge and Evidence: A Policy Perspective” Dr Tony Holohan Chief Medical Officer, Department of Health and Children, Ireland Session 1 - Chairs: Dr Damien Ryan and Prof Austin Stack 09.50 The changing epidemiology of newly diagnosed HIV infections in Clare, Limerick & Tipperary North, 2010 to 2014. Presenter: Keith Ian Quintyne 10.00 Innovation in health services delivery: Do we need radical innovation to address social inequalities in access to, and potential to benefits from health services? Presenter: Eileen Humphreys 10.10 Significant variation in blood transfusion practice persists following Idiopathic Adolescent Scoliosis surgery. Presenter: Sandra O’Malley 10.20 We do fun things together: How adults with intellectual disabilities in Ireland navigate stigma to create lasting friendships. Presenter: Geraldine Shiels 10.30 Assessing the effectiveness of CPR on a manikin with a feedback device. Presenter: Eoghan Connolly 10.40 Risk of Acute Coronary Events and Coronary Interventions for Overweight and Obese patients versus normal weight patients undergoing Dialysis; A National Study. Presenter: Clare Miller _________________________________________________________________________________________ 10.50am-11.10am Coffee/Tea Break Session 2 11:10am-2.00pm Invited Speaker (CAN) Chair: Dr Damien Ryan 11.10am–11.55am “Jump Starting Research in Resuscitation: A Canadian Story” Professor Laurie Morrison Robert & Dorothy Pitts Research Chair in Acute Care & Emergency Medicine, Professor and Clinician Scientist in the Division of Emergency Medicine, Department of Medicine at the University of Toronto and Li Shing Knowledge Institute at St. Michael’s Hospital, Canada ________________________________________________________________________________ 12.00pm-1.00pm Networking Lunch and Poster Viewing ________________________________________________________________________________ Session 2 – Chairs: Mr Brian Lenehen, Dr Phil Hodnett and Dr Damien Ryan 1.00 Development of a Novel Test of Visuospatial Cognition: The Letter and Shape Drawing Test. A study of performance in Hospitalised Elderly Patients and Young Healthy Adults. Presenter: Debbie White 1.10 A Microfluidic Platform for analysis of treatment of E. Coli and Breast Cancer cell models. Presenter: Marie Keays 1.20 Identification of Genetic Biomarkers for Metastatic Colorectal Cancer. Presenter: Christopher Hayes 1.30 Employing a Software Quality Plan within a Distributed Team Environment. Presenter: Noel Carroll 1.40 An in vitro bioassay to study the bioactivities of nutrient compounds for hypertrophy and/or recovery of skeletal muscle. Presenter: Sylvia Murphy 1.50 High throughput screening for combinational drug discovery. Presenter: Finola Cliffe Session 3 2.05pm– 4.10pm Invited Speaker (IRE) 2.05pm-2.55pm: Chair: Prof Paul Finucane “The mesentery in Crohn’s disease – friend or foe” Professor J Calvin Coffey Foundation Chair Surgery, Graduate Entry Medical School, University of Limerick Consultant General and Colorectal Surgeon, University Hospitals Limerick _________________________________________________________________________________ 2.55pm-3.10pm Coffee/Tea Break _________________________________________________________________________________ Session 3 - Chairs: Prof Paul Finucane and Prof Austin Stack 3.10 Management of a positive sentinel lymph node at University Hospital Limerick– Oncological patterns of care. Presenter: David Lynch 3.20 Glycaemic Control Is Comparable In Patients with or without Significant Hepatic Fibrosis As Assessed By NAFLD Fibrosis Score. Presenter: Zeshan Siddiqui 3.30 A review of thyroid sonographic features and international guidelines; ability to differentiate benign and malignant nodules. Presenter: Arlene Weir 3.40 Usefulness of Ultrasound in Evaluating the Recovery of Diaphragm Paralysis. Presenter: Shahzaib Saleem 3.50 High sensitive troponin t levels following elective external direct current cardioversion for atrial fibrillation and atrial flutter. Presenter: Ronstan Lobo 4.00 Public health benefits of commuter cycling in urban environments – infrastructure modification and bike-share for facilitating mode shift. Presenter: Bradley Taylor Invited Speaker (IRE) Chair: Mr Brian Lenehan 4.15pm-5.00pm “The Idea of a Research Institute - scientific highlights from mining the microbiome” Professor Fergus Shanahan Professor and Chairman of the Department of Medicine, University College Cork (UCC), Cork, Ireland 5.00pm-5.30pm Prize Presentation with Invited Speakers 5.30pm-6.00pm Relax 6.00pm-6:45pm Reception on Level 6 followed by Dinner in City View Suite at 7pm. Speaker Biographies Dr Tony Holohan Dr Tony Holohan was appointed as Chief Medical Officer in December 2008. responsibilities include: 1. 2. 3. 4. 5. 6. 7. 8. 9. His Leading on patient safety and quality in health care Leading on public health (health promotion, health protection including emergency planning, health improvement) Leading on reproductive health and social inclusion Providing expert medical evidence, analysis and advice to the Minister, Ministers of State and to the Department Contributing to the development and implementation of policy and services in relation to the health services as a whole Working with the medical profession on policy and professional matters and playing a lead role in maintaining good working relationships between the Department and the profession Developing good working relationships with relevant external agencies and stakeholders, both nationally and internationally, particularly the HSE, HIQA and the Medical Council Communicating Departmental positions in the media and at national and international fora Providing a high quality training environment and experience for the Specialist Training Programme in Public Health. Dr Tony Holohan qualified from UCD in 1991 and trained initially in General Practice and subsequently in public health medicine. He was appointed as Deputy Chief Medical Officer at the Department of Health and Children in 2001 where he worked on the Health Strategy, Primary Care Strategy National Health Information Strategy. He has more recently worked on the new National Cancer Control Strategy as a member of the National Cancer Forum. He is also a member of the National Cancer Registry Board and the Health Research Board. He has previously been a member of the Board of the Faculty of Public Health Medicine. Professor Laurie Morrison Dr. Laurie Morrison is the Robert & Dorothy Pitts Research Chair in Acute Care & Emergency Medicine, Professor and Clinician Scientist in the Division of Emergency Medicine, Department of Medicine at the University of Toronto and Li Ka Shing Knowledge Institute at St Michael’s Hospital. She is the Director of Rescu, a resuscitation research program focusing on the evaluation and implementation of prehospital and transport medicine time sensitive interventions in acute emergencies (www.rescu.ca). She conducts systematic reviews and meta-analyses in topics pertaining to Acute Coronary Syndrome and Resuscitation and has established a collaborative network to conduct randomized controlled trials and outcome validation studies in prehospital resuscitation research. She is a US National Institute of Health, Canadian Institute of Health Research and Heart and Stroke Canada funded investigator within the Resuscitation Outcomes Consortium. She is a past Chair and current member of the Advanced Cardiac Life Support committee of the American Heart Association and on the Editorial Board of the 2010 guidelines in Resuscitation as the Co-Chair of the International Liaison Committee of Resuscitation Advance Life Support Taskforce in 2010. She is the current chair of the Research and Policy Planning Advisory Committee for Heart and Stroke Canada. She was born and educated in Peterborough Ontario, completed her undergraduate at Queens and her medical degree at McMaster. She completed postgraduate training in Emergency Medicine at McGill prior to completing her fellowship at U of T and returning to McMaster in 2000 to obtain a graduate degree in health research design. She has received the Canadian Medical Association award in mentorship; the May Cohen award and was recently celebrated for excellence in mentorship at U of T with the Department of Medicine Bob Hyland award. Research Interests: Prehospital and transport medicine, resuscitation research, medical futility decision rules, emergency health care delivery, acute coronary syndrome, cardiac arrest, life threatening trauma Professor J Calvin Coffey Professor Calvin Coffey is Foundation Chair of Surgery at the Graduate Entry Medical School (GEMS), University of Limerick and Consultant Colorectal Surgeon at University Hospital Limerick, Ireland. His clinical focus is in colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), and pelvic floor abnormalities. Professor Coffey is Deputy Director of 4i Research Centre, at the Graduate Entry Medical School, University of Limerick where scientific studies are directed at exploring innovations in the pathobiology, prevention and treatment of infection, inflammation and immunology. He is the recipient of the international James IV Travelling Fellowship Award for his work in colorectal cancer surgery and his scientific research in the field. In 2012 he was recipient of the Cleveland Clinic Distinguished Alumnus award. He is also the recipient of over 45 national and international awards, has over 180 publications and has delivered several named national and international lectures (Millin lecture, 2012, Sir Thomas Myles Lecture 2011, inaugural Young Investigator Lecture at the Surgical Infection Society of Europe). After initially training in Cork University Hospital, where he received a PhD for work on cancer growth, he then trained in the Mater Misericordiae Hospital; St.Vincent’s University Hospital and finally completed a fellowship in colorectal surgery at the Cleveland Clinic. He has delivered invited lectures in The Johns Hopkins, Memorial Sloan Kettering, The Cleveland Clinic and The European Institute of Oncology. Professor Coffey Foundation Chair of Surgery at the Graduate Entry Medical School, University of Limerick and University Hospitals Limerick. Professor Coffey is a general and colorectal surgeon with a special interest in minimally invasive (keyhole) surgery. His clinical focus is in colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), pelvic floor abnormalities. Professor Fergus Shanahan Fergus Shanahan MD, DSc, is Professor and Chairman of the Department of Medicine and Director of the APC Microbiome Institute at University College Cork (UCC). The APC investigates host-microbe interactions in health and disease, now has a membership of over 170 staff, scientists and students, and is funded by Science Foundation Ireland and by research alliances with companies within the food and pharmaceutical sectors. Dr. Shanahan attended medical school at University College Dublin. After internship and residency at the Mater hospital, he completed fellowships in clinical immunology at McMaster University, Canada, and in gastroenterology at University of California, Los Angeles (UCLA). At UCLA he rose to the rank of Associate Professor with tenure before returning to Ireland in 1993. Dr. Shanahan has published over 450 scientific papers and has co-edited several books. He has also published several articles on the medical humanities, including an award winning essay entitled ‘Waiting’. He is a Fellow of the Royal College of Physicians in Ireland, Canada, and the United Kingdom as well as of the American College of Physicians. He is a former President of the Irish Society of Gastroenterology, was named to the “Irish Life Science 50” a list of the top 50 Irish and Irish Americans in the life science industry, and recently was awarded the Irish Society of Immunology medal and public lecture award. In 2013, Science Foundation Ireland named him as its Researcher of the Year. His interests include mucosal immunology, gut microbiota, inflammatory bowel disease, and most things that affect the human experience. Organising Committee UHL Research Symposium Professor Austin Stack, Chair of Medicine, Consultant Nephrologist, University Hospital Limerick Mr Brian Lenehan, Consultant Orthopaedic Surgeon, University Hospital Limerick Dr Damien Ryan, Consultant in Emergency Medicine, University Hospital Limerick Professor Paul Finucane, Chief Academic Officer, University Hospitals Limerick Ms Mary Clarke Moloney, Clinical Operations Manager, Health Research institute (HRI), UL Ms Maire Bhreathnach, Graduate Entry Medical School, UL Ms Karen Kemmy, Health Research Institute, UL Scientific Review Committee Prof Colum Dunne, Foundation Chair & Director of Research, Graduate Entry Medical School, UL Prof Paul Finucane, Chief Academic Officer, University Hospital Limerick Dr Tony Moloney, Vascular/Endovascular Surgeon, University Hospital Limerick Dr Philip Hodnett, Consultant Radiologist, University Hospital Limerick Mr Brian Lenehan, Consultant Orthopaedic Surgeon, University Hospital Limerick Dr Damien Ryan, Consultant in Emergency Medicine, University Hospital Limerick Dr Patrick Kiely, Lecturer, Dept of Life Sciences, UL Prof Fiona Murphy, Professor of Nursing & Midwifery, EHS, UL Dr Julie O’Brien, Consultant Radiologist, University Hospital Limerick Prof Mike Watts, Consultant Physician Acute Medicine, University Hospital Limerick Prof Catriona Kennedy, Professor of Nursing, UL Dr Susan Coote, Lecturer in Clinical therapies, UL Dr Michael Walsh, Biomedical Engineering, UL Prof Mike Larvin, Head of Graduate Entry Medical School, UL Dr Mary Clarke Moloney, Clinical Operations Manager, Health Research institute (HRI), UL Dr Andrew O’Regan, Senior Lecturer, Graduate Entry Medical School, UL Dr James O’Hare, Consultant Endocrinologist, University Hospital Limerick Session 1: Oral Presentations 9.50am – 10.50am Presenting author information Title Dr First name: Keith Ian Family name: Quintyne Dept. and Department of Public Health Organisation Email: [email protected] Presentation title The changing epidemiology of newly diagnosed HIV infections in Clare, Limerick & Tipperary North, 2010 to 2014 Co-authors KI Quintyne1, M Morris-Downes1, B Mooka2, R Fitzgerald1, M Mannix1 1: Department of Public Health, HSE Mid-West, Limerick 2: Department of Infectious Diseases, University Hospital Limerick, Limerick Oral Presentation Abstract Introduction: To study the current epidemiology of newly diagnosed HIV infections in Clare, Limerick & Tipperary North (HSE MW) and describes the trends over time. Methods: Data were collected from 1st January 2010 to 31st December 2014 from enhanced surveillance records in DPH for HSE MW. A total of 91 cases were identified. A descriptive analysis of demographic and clinical information was performed. Results: In 2014, 18 new cases of HIV were diagnosed in HSE MW, representing a 29% increase compared with 2010. Between 2010 and 2014, the average age of cases declined from 35 years to 32 years and the male: female ratio remained unchanged. The proportion of cases born outside of Ireland increased from 21% to 44%. This was associated with an increase in cases of Black ethnicity from 7% to 17%. MSM transmission was the most common in 2014, showing an increase from 43% to 67% over the 5 year interval. The median CD4 count remained unchanged. The median viral load increased from 12012 to 21776 copies/ml. The proportion of cases presenting asymptomatically decreased from 67% in 2010 to 50% in 2014. The proportion of cases presenting with co-infections with syphilis and Hepatitis C both increased (0% to 17% and 0% to 6% respectively), while other STI co-infections patterns remained unchanged. Conclusions: There has been an increase in the annual number of cases of diagnosed HIV infections seen since 2010. Changes in the epidemiology of newly diagnosed HIV were seen by age, mode of transmission, country of birth and co-infections with STIs. These changes and increases have implications for the prevention, planning and financing of HIV services in HSE MW. Presenting author information Title Dr. First name: Eileen Family name: Humphreys Dept. and Institute for the Study of Knowledge in Society Organisation Email: [email protected] Presentation title Innovation in health services delivery: Do we need radical innovation to address social inequalities in access to, and potential to benefits from, health services? Co-authors E Humphreys, C Browne, C Garavan Oral Presentation Abstract Introduction: Paper based on evaluation of a programme to improve outcomes for children living in severe social deprivation. Included interventions in population health and primary care (speech and language therapy and Public Health Nursing). Programme objectives included innovation, multi-agency cooperation, user involvement and evidence-based approaches. Methods: Applied mixed methods, with an emphasis on a qualitative strategy. Research design involved theory-based evaluation and a method known as contribution analysis (providing credible assessments of cause and effect when it is not practical to design experiments to assess performance). It utilized Participatory Action Research (PAR) approaches with stakeholders including management and frontline staff. Primary research focused on observation via participation in meetings and other activities (training, mentoring, service delivery to users). This involved 107 engagements with services personnel and some clients. Results: Capacity building and empowerment of staff can be achieved by working with PAR approaches. For primary care to achieve better outcomes for children, services need to engage effectively with parents. Parents from severely socially disadvantaged background are not health-literate; they lack awareness of the impact they have on their child’s development including oral language acquisition in early childhood. Improved reach and engagement with users can be achieved by working in universal services especially schools and crèches. There are challenges for health services professionals working in community settings linked to different cultures, professional identities and practice. HSE is perceived negatively; while “rebranding” a service involving users can considerably increase uptake and potential benefits. Conclusions: Universal health services involve complex systems not well-suited to meeting needs of socially disadvantaged populations. Even with access to services free of charge, many do not benefit from them. Small incremental changes in service delivery can yield promising results and achieve efficiencies. These involve actions to address structural inequalities and also behavioral change in the target population. Radical innovation involving higher risks are not always necessary. Presenting author information Title (Dr, Mr, etc) Miss First name: Sandra Family name: O’Malley Dept. and Surgical Health Outcomes Research Enterprise, Department of Surgery Organisation Email: [email protected] Presentation title Significant variation in blood transfusion practice persists following Idiopathic Adolescent Scoliosis surgery. Co-authors Sandra O’Malley, Christopher Aquina, Fergal Fleming, Natasha O’Malley Oral Presentation Abstract Introduction: Perioperative blood transfusions are costly and linked to adverse clinical outcomes. We investigated the factors associated with variation in blood transfusion utilization following primary spinal fusion for idiopathic adolescent scoliosis (IAS) and its association with infectious complications. Methods: Data was extracted from the Statewide Planning and Research Cooperative System (SPARCS), a hospital discharge database for New York State in the United States. Using International Classification of Diseases (ICD-9), all patients included had a diagnosis of IAS and underwent spinal fusion from 2000 to 2013. Individual surgeon and facility volume were calculated as the number of spinal fusions performed per year using the unique surgeon identifier and unique facility identifier numbers. Bivariate and mixed-effects logistic regression analyses were performed to assess the factors associated with receiving a perioperative allogeneic red blood cell transfusion. Additional multivariable analysis examined the relationship between transfusion and infectious complications. Results: Among 6,230 patients who underwent IAS surgery, 27.77 % of patients received a perioperative blood transfusion. After controlling for patient, surgeon, and hospital-level factors, significant variation in transfusion rates was present across both surgeons and hospitals with a 13-fold difference observed in transfusion rates between the lowest and highest utilization for hospitals and a 4-fold difference observed for surgeons)(p < 0.0001).Blood transfusion was also independently associated with wound infection (OR = 2.18, 95% CI = 1.16 and 4.10), and pneumonia (OR = 1.77, 95% CI = 1.24 and 2.51). Conclusions: Significant variation in perioperative blood transfusion utilization exists at both the surgeon and hospital level. These findings are unexplained by patient-level factors and other known surgeon and hospital characteristics, suggesting that variation is due to provider preferences and/or lack of standardized transfusion protocols. Implementing institutional transfusion guidelines is necessary to reduce unwarranted variation and possibly decrease infectious complication rates. Presenting author information Title Ms First name: Geraldine Family name: Sheils Dept. and Research Assistant, Department of Clinical Therapies, University of Organisation Limerick Email: [email protected] Presentation title We do fun things together: How adults with intellectual disabilities in Ireland navigate stigma to create lasting friendships Oral Presentation Abstract Introduction: Friendship is a voluntary relationship offering support, loyalty and well-being. For people with intellectual disabilities, friendship can be interrupted by stigmatizing experiences. This study sought to understand the dynamics within interpersonal relationships for people with intellectual disabilities across multiple environments despite experiencing stigma. Methods: In depth semi-structured interviews were conducted with eleven people with intellectual disabilities ranging in age from 20 to 47 years focusing on how they created meaningful friendships. Interviews were transcribed, cleaned and imported in Atlas.ti qualitative software for thematic analysis. Results: Four themes emerged from the findings: Initiating Friendship, Maintaining Friendship, Interference on Friendship and Sustaining Friendship. The findings provided a nuanced understanding of how friendships are strengthened and deepened through mutual trust, reciprocity, and shared experiences. For many, friendships were sustained through shared histories and shared social spaces. At times, interference on friendship occurred through stigmatizing attitudinal barriers, personal conflict and online conflict. However, peer mentoring and self-advocacy proved viable strategies used by participants to actively disrupt stigma, and continue with their friendships. Conclusions: Protective factors in the form of peer relationships, friendship and peer mentoring can disrupt stigma and build social connections. The value of these social connections reflects the central premise of social capital. Occupational therapists are well positioned to afford practical application of social capital strategies. In particular, peer mentoring and self-advocacy can assert full community participation for people with intellectual disabilities. In the approach to Ireland’s ratification of the United Nations Convention of the Rights of Persons with Disabilities, and the proposed reconfiguration of Irish disability services, it is timely to strengthen social capital among people with intellectual disabilities to prevent further isolation and marginalization across their lifespan. Presenting author information Title Mr First name: Eoghan Family name: Connolly Dept. and National Ambulance Service Organisation Email: [email protected] Presentation title Assessing the effectiveness of CPR on a manikin with a feedback device Co-authors Ms B Sinnott, Dr N Cummins Oral Presentation Abstract Introduction: High quality cardiopulmonary resuscitation (CPR) is a key link in the chain of survival for outof-hospital cardiac arrest (OHCA). Practitioners and responders are required to recertify regularly in CPR and to deliver this care to critically ill patients thereafter. Time spent on the chest performing compressions is seen as a critical element for patient survival. Methods: The objective of this manikin study was to determine quality of CPR and chest compression fraction time (CCF) using the TrueCPR feedback device (Physio-Control) in two cohorts; Group 1 (n=35) were Responders as per Pre-hospital Emergency Care Council (PHECC) standards. Group 2 (n=32) were PHECC Practitioners and other trained Medical Professionals. Participants performed 4 minutes of CPR and delivered 1 shock via an Automated External Defibrillator (AED) to a CPR manikin. The TrueCPR device evaluated the compression rate, depth and chest recoil data producing a percentage of “good” compressions. Results: Mean percentage of good compressions for the Responder group was 18% vs. 21% for the Practitioner group (p=0.55). The practitioner group had better recoil rates and compression depths than the responders. Chest compression fraction indicated that both groups performed compressions for 65% of the time allowed. The highest recorded CCF figure was 77% during the trials. During the charge phase for the shock only 13% of practitioners performed compressions while no responders performed compressions while the AED charged. TrueCPR also produced time for the longest pause during each test, on average responders paused for 24 seconds vs. 21 seconds for practitioners (p=0.13). Conclusions: Good compression rates were similar between responders and practitioners and do show room for improvement. As expected practitioners did outperform responders in some key aspects of CPR. Feedback devices for training and use during OHCA incidents would help guide all rescuers to maintaining high quality CPR. Presenting author information Title Miss First name: Clare Family name: Miller Dept. and Nephrology Department, University Hospital Limerick Organisation Email: [email protected] Presentation title Risk of Acute Coronary Events and Coronary Interventions for Overweight and Obese patients versus normal weight patients undergoing Dialysis; A National Study Co-authors AG Stack, JP Ferguson Oral Presentation Abstract Introduction: In the general population increased body mass index (BMI) has an established deleterious effect on all cause and CV mortality. An obesity paradox has been uncovered among dialysis patients, which suggests the converse may hold true. No literature to date has examined the association between BMI in dialysis patients and acute CV events. Also no research thus far has analysed the impact of BMI on access to acute coronary interventionsa among dialysis patients. Methods: We tested this hypothesis in a national cohort of 1,028,353 incident US dialysis patients between 5/1995 to 12/2008. Patients were classified into BMI (kg/m2) categoriesb according to WHO criteria. Hospitalizations attributed to first myocardial infarction (MI) [ICD 9 codes; 410] and major coronary interventions following first MI were obtained from the US Renal Data System. Multivariable Cox regression compared [HR] of MI and subsequent coronary interventions among BMI categories. Results: Among both sexes (p=0.15) and all races (except Native Americans) the adjusted HR of MI was highest for underweight patients [HR 1.03 CI (0.99-1.07)] and lowest among the class III obese patients [HR 0.84 CI (0.80-0.88)]. Significant heterogeneity was detected between races groups (p=0.049) with BMI having the greatest effect on risk of MI among black patients. Following an AMI underweight [HR 0.90 CI (0.81-1.01)] and class III obese patients [HR 0.93 CI (0.84-1.02)] were significantly less likely to receive a major coronary intervention compared to the intervening overweight [HR 1.17 CI (1.11-1.24)] and class I obese [HR 1.08 CI (1.02 -1.16)] BMI categories. Conclusions: In contrast to the general population higher BMI is associated with lower risk of MI in US dialysis patients. This effect is especially significant in Black patients. Furthermore White, Black and Native-Americans at both extremes of weight are experiencing reduced rates of major coronary interventions post MI suggesting access to coronary interventions is not equal across BMI categories. A Coronary Interventions: Percutaneous coronary intervention, Angioplasty, Coronary artery bypass graft B BMI categories: underweight (BMI < 18.5 Kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25-29.9 kg/m2), obesity-class 1 (BMI 30-34.9 kg/m2), class 2 (BMI 35-> 39.9 kg/m2) and class 3 (BMI>40kg/m2) Session 2: Oral Presentations 1.00pm – 2.00pm Presenting author information Title Dr. First name: Debbie Family name: White Dept. and Department of Anaesthetics, University Hospital Galway Organisation Email: [email protected] Presentation title Development of a Novel Test of Visuospatial Cognition: The Letter and Shape Drawing Test. A study of performance in Hospitalised Elderly Patients and Young Healthy Adults Co-authors OA Williams, M Leonard, C Exton, D Adamis, A Hannigan, CP Dunne, D Meagher Oral Presentation Abstract Introduction: Conventional bedside tests of visuospatial function such as the Clock Drawing (CDT) and Intersecting Pentagons (IPT) are subject to considerable inconsistency in their delivery and interpretation. We compared the use of a novel test - the Letter and Shape Drawing Test (LSD) – with these conventional tests in cognitively intact young persons and hospitalised elderly patients. Methods: Performance on the LSD, IPT, CDT and the Montreal Cognitive Assessment (MoCA) was assessed in 80 participants; 40 acutely unwell elderly (aged >=65) medical inpatients at University Hospital Limerick and 40 final year medical students. Results: The elderly medical patients had a median MoCA score of 15.5 (SD: Range = 1 to 29) as compared with 26.7 (Range = 23 to 30) for the medical students. For the elderly patients, there was a strong, positive correlation between both the LSD and the CDT (r=0.56) and IPT (r=0.71). The correlation between the LSD and MoCA (r= 0.91) was greater than for the CDT and IPT (both 0.67). The LSD correlated highly with all MoCA domains (ranging from 0.540.86) and especially for the domains of orientation (r=0.86), attention (0.81) and visuospatial function (r=0.73). Two or more errors on the LSD identified 90% (26/29) of those patients with MoCA scores of ≤ 20 which was substantially higher than for the CDT (59%) and IP (55%). Conclusions: The LSD is a novel test of visuospatial function that is brief, readily administered and easily interpreted. Performance on this test correlates strongly with other tests of visuospatial ability and these preliminary findings suggest favourable ability to identify patients with significant impairment of general cognition. Presenting author information Title Ms First name: Marie Family name: Keays Dept. and Stokes Laboratories, University of Limerick Organisation Email: [email protected] Presentation title A Microfluidic Platform for analysis of treatment of Breast Cancer and the Identification of Antibiotic Resistance in Bacterial Cultures Co-authors T. Dalton and P.A.Kiely Oral Presentation Abstract Introduction: Cell culture methods provide an initial step when understanding a disease. They provide information that can give genetic identification of disease that can aid in the diagnosis and for an effective treatment. However, the methods that are used for these cultures have changed very little since there first establishment. Cell culture methods rely on consumable plastic ware and valuable personnel time to perform these methods. The generation of a microfluidic droplets provides a method that can reduce the size of these cultures to under 1ul but also increase the throughput through automation. This research will demonstrate how microfluidic droplet cell culture is a robust environment for cell proliferation.This facilitates the establishment of a set of parameters that lie closer to in-vivo conditions Methods: Design and prototyping of a microfluidic droplet platform for the generation of droplet cell cultures of 500nl-1000nl in volume. As each droplet acts as a single bioreactor, this will enable individual three-dimensional cancer models be tested against a specific treatment. This system has also developed bacterial models for the identification of effective treatment or antibiotic resistance to drugs. Results: A nano-litre scale breast cancer model has been developed and treated successfully providing a genetic profile that compares to current methods . This breast cancer model is 600nl in volume compared to a culture flask of 10ml. E.coli cultures have been developed in the microfluidic droplets and the identification of antibiotic resistance as well as an effective treatment were completed in four hours in an automated process. Conclusions: The instrument developed here identified treatments for bacterial and mammalian cell models. The culture droplets are created in a nano-litre range and multiple unique bioreactor droplets can be prepared and analysed on one system making this a time and cost effective instrument. Presenting author information Title Mr. First name: Christopher Family name: Hayes Dept. and Stokes Laboratories, University of Limerick Organisation Email: [email protected] Presentation title Identification of Genetic Biomarkers for Metastatic Colorectal Cancer Co-authors CM Dowling, C Hannan, JC Coffey, PA Kiely, TM Dalton Oral Presentation Abstract Introduction: In patients who have been diagnosed with cancer, biomarkers have many potential applications including differential diagnosis, prediction of response to treatment and monitoring of progression of disease. To identify potential biomarkers, large scale gene expression profiling is an essential tool for the biological investigations of pathological samples. However, this approach is often limited by the availability of large amounts of biological sample for RNA extraction. Methods: From an engineering perspective, we are using continuous-flow microfluidic droplets which act as distinct miniature reactors to quantify gene expression levels of both normal and cancer samples taken from a patient cohort. Microfluidics provides numerous advantages for this application including economies of scale, parallelisation and increased sensitivity that come from nanolitre reactions. From a biological standpoint, our focus is on genes (n=34 in our study) that are regulating extracellular matrices (ECM) which are central components of a tumour’s microenvironment. ECM dysregulation contributes to the transformed phenotype by providing specific environmental cues that alter cell behaviour and increase the metastatic potential of cancer cells. Results: In a small patient cohort (n=24) of matched benign, stage I, II, III, and documented metastatic samples, a pattern of differentially expressed ECM associated genes has emerged between tumour-associated normal and diseased tissue of the same patient. Integrin & matrix metalloproteinase (MMP) families are among those most dysregulated in the patient samples analysed. Conclusions: Expanding this profile may help separate colorectal cancer into distinct ‘extracellular matrix protein expressing’ groups from which we will be able to develop robust diagnostic and prognostic tools that can be applied in a clinical setting. Furthermore, significant associations of gene expression levels and clinicopathological variables such as tumour size, grade, invasion and lymph node status may be identified. Presenting author information Title Dr First name: Noel Family name: Carroll Dept. and ARCH - Applied Research for Connected Health Technology Centre, Department Organisation of Computer Science & Information Systems, University of Limerick Email: [email protected] Presentation title Employing a Software Quality Plan within a Distributed Team Environment Co-authors I Richardson Oral Presentation Abstract Introduction: TRANSFoRm, an EU-funded FP7 project, proposed to develop a ‘rapid learning healthcare system’ driven by advanced computational infrastructure that would improve both patient safety and the conduct and volume of clinical research in Europe. To achieve this, software development was required. In order to support the software development process, a TRANSFoRm Software Quality Plan played a critical role. The TRANSFoRm Software Quality Plan combined healthcare regulations with software regulations which the distributed team had to comply with throughout the project development. Methods: Building on the TRANSFoRm Software Quality Plan we examined how it supported the TRANSFoRm software developers to build in a level of quality into their tools. The various stages of the plan were devised based on published software processes and Medical Device Regulations. We revisit this Software Quality Plan with the aim of reviewing how it was implemented, how it contributed towards the success of the TRANSFoRm project and whether there are any valuable ‘lessons learned’ from the healthcare technology project. Specifically, we interview the development teams located in the UK, Ireland and Poland which constitute as key members of the distributed project team. With a view to understand how software standards can support medical device regulation, we surveyed the TRANSFoRm Work Task team using the Software Quality Plan to examine how they implemented the plan to successfully meet the projects aim and objectives. Results: We uncovered the complexities and challenges to establish a developer community that align healthcare requirements and software development processes with other stakeholders. Common challenges include introducing new partners to one another and developing new working relationships, vocabulary used in healthcare and computer science domains, exploratory nature of research, politics between working groups, decision-making and empowerment, visibility and transparency of activities, impact of development on other tasks. Going forward with other large health technology EU projects, establishing project management and collaboration structures will play a significant role in the success of distributed software development projects. The Software Quality Plan proved to be a critical resource. Of particular importance is the need for the inclusion of a Work Package to Set up the Software Development Strategy and Management Policy when proposing future EU healthcare technology projects, such as Horizon 2020. Conclusions: The TRANSFoRm was an exciting project to enhance patient safety and the conduct clinical research in Europe. Our findings also indicate that additional emphasis must be placed on strategy, not technology, at the beginning of a distributed software project since this ultimately drives the digital transformation and ensures that technical milestones are met. Our results also indicate that the Software Quality Assurance Framework proved to be a core resource for the TRANSFoRm project providing a common goal and vocabulary for all of the TRANSFoRm team to focus on throughout the software development process. Through the use of the Software Quality Plan, TRANSFoRm could successfully meet the project objectives and maintain a high quality of standard in capturing clinical data, achieve a distributed interoperability of data and developed unique software tools and healthcare services. Presenting author information Title Ms. First name: Sylvia. M Family name: Murphy Dept. and Department of Life Sciences Organisation University of Limerick Email: [email protected] Presentation title An in vitro bioassay to study the bioactivities of nutrient compounds for hypertrophy and/or recovery of skeletal muscle Co-authors M Kiely, P Jakeman, P.A. Kiely and B.P Carson Oral Presentation Abstract Introduction: The regulation of muscle protein metabolism to maintain or augment lean tissue mass (LTM) is of primary importance to athletes and healthy ageing cohorts alike. Identifying nutrient regulators of muscle protein metabolism to support recovery from and maintenance of healthy muscle is of particular interest. The aim of this investigation was to develop a novel in vitro cell-based electric impedance assay to study nutrient regulation of muscle cell hypertrophy and recovery. Methods: C2C12 skeletal muscle myoblasts were proliferated until 70% confluent in DMEM (10% FBS) and subsequently differentiated to myotubes over 8 days in DMEM (2% HS) on a Real Time Cell Analysis (RTCA) platform (xCELLigence™, ACEA). Changes in cell behavior and adhesion properties were monitored by measuring impedance via interdigitated microelectrodes in the base of cell culture dishes. To monitor nutrient regulation of muscle hypertrophy, C2C12 skeletal muscle myotubes were incubated in physiologically relevant concentrations of leucine (0.20, 0.40, 0.6, 0.8mM), a known potent regulator of MPS and continuously monitored on RTCA. To assess muscle recovery, C2C12 skeletal muscle myotubes were subject to dexamethasone (20uM), a known atrophic agent, followed by ‘recovery’ of C2C12 myotubes in amino acid free media supplemented with leucine. Results: We have developed a robust real-time bioassay to study muscle myotube formation and maintenance. Using this novel assay, we show a dose response hypertrophic and recovery effect of leucine (Hypertrophy: Con 100%, 0.2mM Leu 96.6%, 0.4mM Leu 111.9% and 0.8mM 120.6%; Recovery: Con 100%, 2mM Leu 125.6%) on C2C12 myotubes by RTCA. These findings are supported by alterations in MPS (mTOR, P70S6K, 4EBP1, P-MAPK) signaling pathways. Conclusions: This in vitro bioassay can be used to identify nutrients compounds with bioactivities for skeletal muscle hypertrophy and recovery and thus inform the development of novel nutrient formulations. Presenting author information Title Dr. First name: Finola Family name: Cliffe Dept. and Stokes Laboratories, Department of Mechanical, Aeronautical and Organisation Biomedical Engineering Email: [email protected] Presentation title High throughput screening for combinational drug discovery Co-authors M Davies, M Galvin, E O’Shea Oral Presentation Abstract Introduction: ENIGMA is a high throughput screening platform with a focus on the screening of therapeutic drugs, specifically in the area of combination drug discovery. This microfluidic system delivers a low cost, automated, contamination-free and versatile instrument. Currently the pharmaceutical industry is facing long lead times and high development costs. ENIGMA can address these problems by accelerating drug discovery whereby millions of drug compounds can be rapidly screened to generate hits. Generating new synergistic combinations of existing drugs offers a relatively low cost way of bringing new drugs to market. Methods: Several prototype builds of ENIGMA have been completed and are ongoing. Each prototype was carefully designed, built and tested for accuracy and reproducibility. Each drug combination was assayed against whole cells to assess viability via fluorescent detection. Synergistic combinations of FDA approved off-patent drugs were determined based upon ability to kill cells or inhibit cell growth. Results: A series of prototypes have been designed, built and tested with the current prototype equipped to hold 8 wells. Many positive outcomes in flowing droplets have been demonstrated Proved viability of various cell types such as mammalian (MCF7, induced pluripotent stem (iPS) cells) and bacterial (pathogenic and non-pathogenic E. coli) Successful segmentation and mixing of cells and drugs from separate wells Effective drug action on bacterial and mammalian cells Many more encouraging results have been generated from offline experiments Conclusions: It is expected that the final ENIGMA prototype will hold 300 samples and can accommodate combinations of 3 resulting in 4.5 million data points within a 5 day period. It is also anticipated that patient derived iPS cells (disease differentiated) will be employed as disease models for screening of therapeutic drug combinations once the instrument is fully validated. ENIGMA holds the potential to advance research within the healthcare sector. Session 3: Oral Presentations 3.10pm – 4.10pm Presenting author information Title Mr First name: David Family name: Lynch Dept. and Organisation University of Limerick Graduate Entry Medical School Department of Surgery UHL, Mid-Western Cancer Centre UHL, Department Radiation Oncology UHL Email: [email protected] Presentation title Management of a positive sentinel lymph node at University Hospital Limerick– Oncological patterns of care Co-authors C Baban, L Coate, A Lal, S Tormey, A Merrigan, A Hannigan, B Woulfe, L Walsh Oral Presentation Abstract Introduction: To determine how patients with early stage breast cancer and a positive sentinel lymph node (SLN+ve) are further managed at our institution (surgically, systemically, radiotherapeutically) and to determine the factors which influence the approach taken, comparing it to ACOSOG Z0011. Methods: Data was collected on all SLN biopsy procedures conducted between Jan 2010 – July 2014 (n=375) and validated with surgery lists, individual pathology reports, patient charts and electronic records. Graph pad (Chi squared, Fisher's exact test, Chi squared for trend and independence) was used for data analysis. Results: 101 patients had SLN+ve - 62(61%) underwent axillary lymph node dissection (ALND), 39 (39%) had no further axillary surgery (SLNB alone). Factors which impacted the decision to proceed with ALND were a macrometastically SLN+ve (p=0.005), number of SLN+ve (p=0.0029), grade and receptor status (p=0.01). Chemotherapy was given more frequently in the ALND group (p=0.003). In contrast to ACOSOG Z0011, locoregional radiation was given more frequently in both groups, particularly when ALND had been performed (p=0.016). Conclusions: The surgical impact of ACOSOG Z0011 is evident at out institution with 39% of patients who previously would have been considered for ALND receiving SLNB only. Its impact on selection of adjuvant therapy (chemo & radiotherapy) is not apparent, with patients receiving less chemo but more extensive locoregional radiation when compared with the SLNB group of Z0011. Clinical guidelines being developed by the Irish National Cancer Control Programme, have identified this often challenging issue and will be welcome in standardising practice. Presenting author information Title Mr First name: Zeshan Family name: Siddiqui Dept. and Y4 Medicine, GEMS UL Organisation Email: [email protected] Presentation title Glycaemic Control Is Comparable In Patients With Or Without Significant Hepatic Fibrosis As Assessed By NAFLD Fibrosis Score Co-authors Chin JL, Chan G, Sin PS, Siddiqui Z, O’Rathallaigh E, Aftab A, Courtney G, McGurk C Oral Presentation Abstract Introduction: Non-alcohol fatty liver disease (NAFLD) is increasingly recognised in diabetic patients with metabolic syndrome. Patients with poorly controlled diabetes and the metabolic syndrome are likely to have significant liver inflammation leading to fibrosis. NAFLD fibrosis score (NFS) is a validated non-invasive scoring system that identifies liver fibrosis in patients with NAFLD. The aim of this study is to examine the glycaemic control in patients with or without significant hepatic fibrosis as assessed by NFS in the routine diabetic clinic. Methods: All patients with type 2 diabetes or impaired glucose tolerance/fasting glucose, attending the diabetic clinic from March to June 2014 were included retrospectively. Patients with type 1 diabetes and gestational diabetes were excluded. Data were obtained from laboratory database and electronic patient record (Cellma). NFS was calculated for each patient based on age, BMI, diabetes, AST/ALT, platelet and albumin. Results: 521 patients were screened and only 29.4%(153) of patients with complete laboratory data were studied. In our cohort of 153 patients, 64.1%(98) of patients were male and the median age was 63(IQR 56.0–71.5) years. Using the NAFLD fibrosis score, almost a quarter of our patients (24.2%, n=37) had significant fibrosis with a median score of 1.169(0.898–1.563) while the rest of the patients were indeterminate (66.0%, n=101) or had no significant fibrosis (9.8%, n=15). The median BMI for patients with significant hepatic fibrosis was 30.0(27.8– 34.5)kg/m2 while for patients without significant fibrosis (including indeterminate score based on NFS), the median BMI was 34.8(30.3-43.2)kg/m2 (p<0.01). Interestingly, there were no significant differences in the mean HbA1c readings in patients with or without significant hepatic fibrosis (55.2±15.3mmol/mol versus 56.6±17.9mmol/mol; p=0.639). Conclusions: In conclusion, we did not observe any significant differences in glycaemic control in patients with or without significant hepatic fibrosis, as assessed by NAFLD fibrosis score in clinic. Presenting author information Title Ms First name: Arlene Family name: Weir Dept. and Graduate Entry Medical School, University of Limerick. Organisation Email: [email protected] Presentation title A review of thyroid sonographic features and international guidelines; ability to differentiate benign and malignant nodules Co-authors Dr. Declan Sheppard Oral Presentation Abstract Introduction: The aim of this study was to review six sets of internationally accepted thyroid fine needle aspiration guidelines and to assess their accuracy and to examine local adherence to these guidelines. The guidelines used were those created by the American Thyroid Association, the British Thyroid Association, the Korean Society of Thyroid Radiology, the American Society of Radiologists in Ultrasound, Kim Criteria and a combined guideline from the American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi and European Thyroid Association. Methods: A total of 100 thyroid nodules that were diagnosed on ultrasound and subsequently underwent fine needle aspiration cytology were included in this study. The sonographic features of each nodule were examined and the compared with the final cytology and histology reports. The sonographic features were then compared to six sets of thyroid FNA guidelines and their sensitivity, specificity, positive predictive values and negative predictive values were calculated. Adherence to the guidelines was also reviewed. These results were then compared to a similar study of a larger scale. Results: Of the ultrasound features associated with each type of nodule, a cystic/spongiform consistency was found to have a high specificity (91.7%) for benign nodules, with microcalcifications (91.8%) being the most specific for thyroid cancer. There was found to be a greater adherence to more established guidelines. However, this review took place prior to the introduction of the new BTA guidelines (2014), which in our study had the highest combined sensitivity (83.3%) and specificity (67.4%). Retrospective adherence to the BTA guidelines shows that they would have missed only one Thy 5 cancer. Conclusions: All guidelines provide a minimum clinical standard, which is of most benefit to inexperienced operators. For more experienced clinicians, the addition of subjective experience to the new BTA guidelines may provide the highest accuracy. Presenting author information Title Dr First name: Shahzaib Family name: Saleem Dept. and University Hospital Limerick – Dept of Respiratory Medicine Organisation Email: [email protected] Presentation title Usefulness of Ultrasound in Evaluating the Recovery of Diaphragm Paralysis Co-authors Hynes, TS., Saleem, S., Casserly, B Oral Presentation Abstract Introduction: Ultrasound has been proven to be a non-invasive method of diagnosing diaphragm paralysis. However its usefulness in monitoring the progress of diaphragm recovery has not been fully delineated. Therefore we evaluated the usefulness of measurements of diaphragm thickness (dT) and diaphragm thickening during inspiration (iDT) in assessing functional recovery of paralyzed diaphragms. Methods: Sixteen patients diagnosed with diaphragmatic paralysis were followed for a period of 60 months. During which they underwent serial ultrasound measurements of diaphragmatic thickness and its change with inspiration. These measurements were compared with vital capacity (VC), maximal inspiratory (maxIP) and expiratory (maxEP) pressures. Results: Of the 16 subjects, 11 regained fully functional diaphragms. The mean recovery time for the 11 patients was 14.9 month (±6.1). Diaphragms that recovered showed significant increase in both thicknesses from time of paralysis (30.4 ±24.5% vs -1.6±15.5% - P<0.001) and inspiratory diaphragm thickening (40.6 ±17.9% vs 1.8±8.0% P<0.05) compared to those that did not. Additionally change in diaphragm thickness was shown to significantly correlate with the change in VC (R2=0.44 P=0.005). Conclusions: Therefore ultrasound shows promise as a useful tool to evaluate the recovery process of patients suffering from a paralyzed diaphragm and should receive further consideration and appraisal in this role. Presenting author information Title Dr First name: Ronstan Family name: Lobo Dept. and Department of Cardiology, University Hospital Limerick Organisation Email: [email protected] Presentation title High sensitive troponin t levels following elective external direct current cardioversion for atrial fibrillation and atrial flutter Co-authors C Cahill, O Blake, S Abbas, TB Meany, T Hennessy, TJ Kiernan Oral Presentation Abstract Introduction: External transthoracic direct current (DC) cardioversion is a commonly used method of terminating arrhythmias, emergently or electively. It is known that external DC cardioversion can result in a rise in creatine kinase (CK). Previous research has shown that DC cardioversion resulted in subtle myocardial injury as evidenced by CK-MB, troponin I and troponin T increase, even though only minimally. These studies were based on the outdated monophasic defibrillators and older troponin assays. Since early 2010, the new high sensitive troponin T (Hs-trop T) assays have been used to diagnose myocardial injury and have been found to be highly sensitive and specific. This study aimed to assess the effect of external transthoracic DC cardioversion on myocardial injury as measured by the change in Hs-trop T using the more modern biphasic defibrillators in an elective setting. Methods: Patients who were admitted for a day-case elective DC cardioversion for atrial fibrillation or atrial flutter were asked to participate in the study. DC cardioversion was performed using the Phillips Heartstart XL biphasic defibrillator. For cardioversions that failed at 200 Joules, the Physio-Control Lifepak 20e 360 J biphasic defibrillator was used. Hs-trop T levels were taken pre-cardioversion and at 6 hours post-cardioversion (in keeping with the Third Universal Definition of Myocardial Infarction guidelines on biomarker detection of myocardial injury with necrosis). The assay used was the Roche Elecsys Troponin T hs (high sensitive) immunoassay. Quantitative analysis for haemolysis, icterus and lipaemia (which could result in interference with the Hs-trop T assay) were measured in each blood sample that was taken using the Abbott Architect c16000. Results: A total of 120 cardioversions were done on 101 patients. Analysis of each of the blood sample taken showed no raised haemolytic, icteric or lipaemic indices above the recommendations for the Hs-trop T assay. Median number of shocks was 1, and the maximum number of shocks was 6. Median cumulative energy was 150 Joules (interquartile range = 387.5 Joules) with the minimum being 50 Joules and maximum being 1730 Joules. A total of 49 (40.8%) patients received a cumulative defibrillation energy of 300 Joules or higher. The highest energy delivered per shock was 360 Joules and median peak impedance levels was 80.80 Ohms (interquartile range = 19.05 Ohms). Median Hs-trop T levels pre-cardioversion was 7 ng/L (interquartile range = 7) and post-cardioversion was 7 ng/L (interquartile range = 6). A Wilcoxon signed-rank test showed no significant difference between pre-and-post cardioversion Hs-Trop T levels (Z = -0.940, p = 0.347). Conclusions: External DC cardioversion did not result in myocardial injury as measured by high sensitive troponin T. The implications of this study is important as patients who are cardioverted and are found to have a significant troponin rise post-cardioversion should be assessed for causes of myocardial injury and not assumed to have myocardial injury due to the cardioversion itself. Presenting author information Title Mr First name: Bradley Family name: Taylor Dept. and University of Limerick – Graduate Entry Medical School Organisation Email: [email protected] Presentation title Public health benefits of commuter cycling in urban environments – infrastructure modification and bike-share for facilitating mode shift Co-authors Taylor B1, Nathan Y1 1 University of Limerick Graduate Entry Medical School, Limerick, Ireland Oral Presentation Abstract Introduction: Positive public health outcomes due to increased levels of physical activity are well documented in the literature. This review seeks to present evidence from existing research regarding both positive and negative health outcomes due specifically to cycling and health outcomes associated with promoting mode shift from private car use to cycling as a means of daily commute. Further, a review is conducted of built environmental factors that promote an effective urban cycling program within a community, and specifically examines research into bike-share as an effective means of promoting commuter cycling within an urban community. Methods: Non-systematic review of the literature uncovered a total of 51 papers (26 health outcomes, 20 built environmental factors, 5 bike-share) that met inclusion criteria of which a great many were cross-sectional or observational studies. Ethical approval was not needed for this review. Results: Greater benefits than harms were seen with relative risk 0.5-0.9 for decreased chronic disease risk, 0.993-1.020 for road traffic accidents, and 1.001-1.053 for inhalational exposure. Specific factors found to be positively correlated to increased cycling are spatial accessibility to green spaces and proximity facilities as well as the availability of cycle paths. Bike-share usage increases with proximity to docking station whereby those living within 250m of a docking station are 2.4 times as likely to cycle. Conclusions: Bike-share systems are good promoters of commuter cycling in many jurisdictions where the following features are positively correlated with their effectiveness: percent coverage of each of major landmarks, schools, places of business, transportation hubs, and total metropolitan area. It is recommended that station density be between 4-7 stations/km-1 for older intelligent station designs, but may be less for intelligent-bike designs. This is to limit the distance that one needs to walk in order to access the network which is of itself, a strong deterrent to public bike share. Poster Presentations POSTER PRESENTATION: HEALTH SERVICES & POPULATION HEALTH RESEARCH ID Presentation Title A01 Dr Environmental determinants and distribution of verotoxigenic Escherichia coli (VTEC) infection in Ireland, 2008–2013 – a geostatistical investigation Dr Management Of New Onset Atrial Fibrillation in Stable Patients Jean Evaluation of the quality of GP referrals to a Dr mental health outpatient service in Limerick City. Dr A Follow-Up Audit of the Adult Midwest Mental Health Assessment form 2015 A03 A04 A05 A06 A07 A08 A09 A10 A11 A12 A14 Title Author Category Dept /Org Health Services & Population Health Research Dept of Life Sciences, UL Mohamed Ahmed A Health Services & Population Health Research Cardiology Dept UHL Dr.Catherine McGorrian Joyce Leader Health Services & Population Health Research Dept of Psychiatry, UHL S. Winkel KIRAN BUDREE Health Services & Population Health Research PSYCHIATRY ACUTE UNIT Dr Sheila Tighe Lymph node ratio (LNR) in sentinel lymph Dr Keith Ian node biopsy (SLNB) era: are we losing prognostic information? Ms Cliodhna Change in Model of Care and Accommodation in a High Dependency Unit: a Comparison Prof Pierce A report of the state of the hospitals in Ireland in the 18th century Quintyne Health Services & Population Health Research Dept of Public Health KI Quintyne Ashe Health Services & Population Health Research Medical Student, UL J. O’Dea Grace Health Services & Population Health Research Dept of Surgery GEMS, UL It's my problem I’ll handle it: A mixed method exploration of psychological distress and help seeking amongst higher education students Characterising self-weighing in a population of Irish general practice patients: a cross sectional study Hydroxychloroquine Cardiomyopathy: Case report and literature review, a rare disease or overlooked diagnosis. Audit of the use of acute hospital beds at Midlands Regional Hospital Tullamore using The Appropriateness Evaluation Protocol (AEP). An evaluation of the experiences of students, community group facilitators & service users who participated with nontraditional physiotherapy student placements Christine Deasy Health Services & Population Health Research Dept of Nursing and Midwifery, UL Mr Michael Crickmer Health Services & Population Health Research Dr Mohamed Ahmed Ms Ceire Ms Anne O'Dwyer Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 C P Hynds M Morris C Adley. ÓhAiseadha Downes Y. Mushtaq B Woulfe JC Coffey RK Gupta B Coughlan D Jourdan J Pironom P MannixMcNamara UL Medical Student Mr. Michael Johnson Dr. Eamonn Dr. Brendan Shanahan O’Shea Health Services & Population Health Research Cardiology Dept, UHL Dr.S Donnelly Dr.A.Fabre McGuane Health Services & Population Health Research GEMS Limerick S. Murray O Connor Health Services & Population Health Research Clinical Therapies Dept, M O’Donnell UL Co-Author 6 Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: HEALTH SERVICES & POPULATION HEALTH RESEARCH (continued) ID Presentation Title A15 Audit: Antibiotic prescribing in primary care A16 What lies beneath: right ventricular paced rhythm with underlying inferior STEMI and paroxysmal atrial fibrillation. ‘This-ability’: Anti-stigma initiatives from the perspective of people living with mental illness Multidisciplinary Primary Care Teams in International Settings: A review of International Policy Prognostic importance of Urea and Urea/Creatinine ratio for mortality as compared to Creatinine concentrations in the General Population Analysis of exercise capacity and health related quality of life in patients two years after completion of a Pulmonary Rehabilitation Programme Case report A thrombus in transit through patent foramen ovale with underlying silent DVT and pulmonary embolism. AUDIT of Pain Management in the Emergency Department of University Hospital, Limerick. Common Variable Immunodeficiency – A Master of Disguise for Sarcoidosis? RISK OF ISCHAEMIC STROKE FOR INCIDENT PATIENTS TREATED WITH PERITONEAL DIALYSIS VERSUS HAEMODIALYSIS Mineral Bone Disease Management in nondialysis Chronic Kidney Disease: Findings from an Irish CKD Survey A17 A18 A19 A21 A22 A23 A24 A25 A26 Title Author Category Dept /Org Co-Author 1 Co-Author 2 Graduate Entry Medicine, Dr Jim Ryan Dr Julie UL McMahon Cardiology Dept, UHL Prof.Kiernan V.Voon Dearbhla Byrne Dr Khalid Mostafa Ahmed Ms Michelle McCann Health Services & Population Health Research Dept of Occupational Therapy, UL Dr. N Salmon Miss Rachael King Health Services & Population Health Research GEMS, Faculty of Education and Health Sciences, UL R. King E. Tierney Mr Ronan Cusack Health Services & Population Health Research GEMS, UL J Ferguson AG Stack Brian Fitzgibbon Health Services & Physiotherapy UHL, Nenagh O Quinn Dr B Casserly Cardiology Dept, St Vincent’s University Hospital Prof.D.Keane M.Quinn Health Services & Population Health Health Services & Population Health Research Population Health Research Dr Khalid Mostafa Ahmed Health Services & Population Health Research Miss Katarzyna Domanska Health Services & Co-Author 3 Co-Author 4 Co-Author 5 Dr Emma Dr Sannah O’Keeffe Sithole A.Abbas U.Azhar M. Ayyaz Co-Author 6 M. O’Sullivan A. MacFarlane Dr A O Brien F Steed S.Mubarak F. Masood GEMS Limerick Population Health Research DR WAN LIN WAN LIN Dr Mohamed Elsayed Dr Muhamma Sharif d Health Services & Population Health Research Health Services & Population Health Research Dept of Respiratory Medicine AD O’Brien Nephrology Dept – UHL J P Ferguson MU Sharif Health Services & Population Health Research Nephrology Dept-UHL M Elsayed MC Moloney A G Stack J Ferguson A Mutwali C Cronin L Casserly A Stack Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: HEALTH SERVICES & POPULATION HEALTH RESEARCH (continued) ID Presentation Title A27 An Audit on Medication Reconciliation in a Dr Tertiary Care Hospital Dr NEVER UNDER DIAGNOSE DELIRIUM! AN AUDIT OF ASSESSMENT OF COGNITION ON ADMISSION OF CONFUSED PATIENTS Dr Novel Methods for Record Linkage in the Irish Health System: Applications to linking Laboratory and Mortality records Dr Long-Term Consequences Of Transient Acute Kidney Injury On Risk Of Death And Kidney Failure In The Irish Health System. Dr PRACTICE PATTERNS IN BLOOD PRESSURE MANAGEMENT AND TARGETS AMONG NONDIALYSIS CHRONIC KIDNEY DISEASE PATIENTS: RESULTS OF A MULTI-CENTRE AUDIT AND NATIONAL SURVEY. Improving Quality of Care for Acute Kidney Dr Injury in the Irish Health System Dr Enhancing alcohol screening and brief intervention among people receiving opioid agonist treatment: Qualitative study in primary care. Ms Screening and brief intervention for problem alcohol use among a high-risk group in primary care: Feasibility study of a complex intervention among people who use drugs MS Using effective documentation style for dietetic consultations in the management of Gestational Diabetes Mellitus ‘Challenges in Accessing and Interviewing Mr Participants with Severe Mental Illness’ Risk Assessment and Management of Osteoporosis in Females over 65 years at Slaney Medical Centre, Enniscorthy, Co. Wexford A28 A29 A30 A31 A32 A33 A34 A35 A36 A37 Title Author Category Dept /Org Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 C.B. Sabu V. Pradeep N. Muthalvan Kowshika Thavarajah Health Services & Population Health Geriatric Medicine, UHL Kowshika Thavarajah Health Services & Population Health Geriatric Medicine, UHL N. Muthalvan A. Gabr V. Pradeep John Ferguson Health Services & Population Health Research GEMS A Hannigan M Sharif A Stack John ferguson Health Services & Population Health Research GEMS M Elsayed M Sharif Mohamme Kaballo d Health Services & Population Health Research Division of Nephrology, Dept of Medicine, UHL MA Kaballo Mohamme Kaballo d Health Services & Population Health Research Health Services & Population Health Research Division of Nephrology, Dept of Medicine, UHL Research Research Co-Author 6 Co-Author 7 Co-Author 8 D. Lyons M.O' Connor H Johnson P Murray A Stack MU Sharif K Hanley ME Elsayed L Ryan A Hannigan LF Casserly CJ Cronin MA Kaballo JZ Qazi GS Ahmed ME Elsayed MU Sharif LF Casserly MM GAFFNEY GEMS, UL G McCombe AM Henihan J Klimas D Swan D Leahy W Cullen R. Anderson G. Bury Geoff McCombe Anne Marie Henihan Health Services & Population Health Research GEMS, UL G. McCombe J. Klimas D. Swan D. Leahy Alexandra Cremona Health Services & Population Health Research GEMS, UL A Cremona A Cotter A Donnelly C O’Gorman Daniel Newman Dept of Nursing and Midwifery, UL P O’Reilly SH Lee C Kennedy Olga Fagan Health Services & Population Health Research Health Services & Population Health Research Medical Student, UL Dr Derek Forde AG Stack Co-Author 9 Co-Author 10 JP Ferguson AG Stack POSTER PRESENTATION: HEALTH SERVICES & POPULATION HEALTH RESEARCH (continued) ID Presentation Title A38 Dorothy A qualitative analysis of risk management Dr and quality improvement strategies for patients and healthcare professionals in primary and secondary care. Pushing hard and fast! An investigation of Mr Eoghan rate and depth of compressions by trained responders and practitioners. Prof Philip An analysis of the body composition of patients with Inflammatory Bowel Disease. Issues concerning the uptake of the seasonal influenza vaccine by nurses working in the long-term older person setting in Ireland’ Development of local area health profiles for the Republic of Ireland Hamstring tendon grafting during anterior cruciate ligament reconstruction. What is the relationship between pre-operative and post-operative hamstring strength? Prevalence of Multimorbidities in Chronic Pain Patients attending outpatient Physiotherapy How physically active are employees at UL Hospitals Group? Use of antipsychotics, antidepressants, and hypnotics/sedatives, in adults with learning disability: a re-Audit The comparative effectiveness of exercisebased group and individual physiotherapy for musculoskeletal conditions: a systematic review and meta-analysis A40 A42 A44 A45 A46 A47 A48 A50 A51 Title Category Dept /Org Leahy Health Services & Population Health Research GEMS Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 M Culliton R Shipsey W Cullen P Finucane J Kennedy Connolly Health Services & Population Health Research National Ambulance Service Ms B Sinnott Dr N Cummins Jakeman Health Services & Population Health Research UL Body Composition Study, Human Science Research Group and 4i Centre for Interventions in Infection, Inflammation and Immunity, UL Infection Prevention & Control Mid West PCCC L Dowling D O Donovan L Doherty Author M Skelly C Dunne Ms Gemma Quinn Health Services & Population Health Research Dr Marie Casey Dept of Public Health Mr Colum Moloney Health Services & Population Health Research Health Services & Population Health Research Physiotherapy Dept, UHL Dr. K O’Sullivan Mr. D O’Farrell, Miss Catherine Quinn Health Services & Population Health Research Physiotherapy Dept, UL Hospitals – Ennis Hospital R Galvin S O’Higgins L O’Connor B McGuire Ms Maire Curran Dept of Physiotherapy , UHL J QuinnMcDonogh B Moran H Brady C Cowan L Tobin. Dr Mary Kelly Health Services & Population Health Research Health Services & Population Health Research Daughters of Charity K Budri N Service for Persons with Subramanian Intellectual Disability A Yousaf A Bashir M Sharif Ms Mary O Keeffe Health Services & Population Health Research Clinical Therapies, UL H Purtill K O’Sullivan A Hayes K Mc Creesh L Cullen D Goggin M O Leary Dr. A. Clifford Co-Author 6 Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: HEALTH SERVICES & POPULATION HEALTH RESEARCH (continued) ID Presentation Title A52 Ms Patient-therapist interactions in musculoskeletal physiotherapy: a qualitative systematic review and metasynthesis. Comparative effectiveness of conservative Ms interventions for non-specific chronic spinal pain: physical, behavioural or combined? a systematic review and meta-analysis. Mary Screening for Perinatal Mental Illness in an Antenatal Booking Clinic: An Audit An Unusual Case of Chlorpromazine Toxicity in the Emergency Department An Audit on the Management of Acute Asthma on Presentation to the Emergency Department. Irish Values for Health – A national Study A53 A54 A55 A56 A58 A59 A60 Title Category Dept /Org O Keeffe Health Services & Population Health Research Clinical Therapies, UL Mary O Keeffe Health Services & Population Health Research Dr Mas Mahady Mohamad Dr Mary Finnan Dr Emer Leonard Health Services & Population Health Research Health Services & Population Health Research Health Services & Population Health Research Dr Roisin Adams Assessing the role of a grade 3 general hospital in diagnosis and management of colorectal cancer Implementing dematerialisation strategies Dr in health services, the importance of interdisciplinary collaboration for scenario development Author Mike Yvonne Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 P Cullinane J Hurley I Leahy S Bunzli P O’Sullivan, Co-Author 6 K O’Sullivan Clinical Therapies, UL H Purtill N Kennedy J Hurley K O’Sullivan Dept of Psychiatry AM Curtin C Corby Anaesthesia, UHL M Finnan E Leonard Emergency Dept, UHL M Finnan T Moriarty Health Services & Population Health Research Gorenchtei Health Services & Population Health n Research National Centre for Pharmacoeconomics B Reddy M Barry P Kind GEMS, UL A Kennedy C Clancy E Myers Ryan Fogarty Dept of Chemical and Dr G Becker Environmental Sciences, UL Health Services & Population Health Research ` Dr B O’Regan P O’Sullivan W Dankaerts C Walsh Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: LIFESTYLE & HEALTH Christine Deasy Lifestyle & Health Dept of Nursing and Midwifery, UL Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 5 2 B Coughlan D Jourdan J Pironom P MannixMcNamara Ms Blathin Casey Lifestyle & Health Clinical Therapies, UL. B Casey S Coote S Hayes INHALED FOREIGN BODIES IN YOUNG CHILDREN- A FORGOTTEN HAZARD? Dr Muhamma Pathan d Khan (MK) Lifestyle & Health Paediatrics, UHL J Twomey B Linnane AM Murphy B06 The direct and indirect associations between Social Cognitive Theory and physical activity in people with Multiple Sclerosis Dr Sara Hayes Lifestyle & Health Clinical Therapies, UL R Motl S Gallagher S Coote B07 Sex Differences in Mood Responses to Acute Aerobic Exercise Mr Cillian McDowell Lifestyle & Health Physical Education and Sport Sciences, UL M Campbell MP Herring B09 Overview of a systematic review of early detection of noise induced hearing loss in relation to otoacoustic emissions. Mr Nesakuma Tulasi ran Lifestyle & Health Community Audiology services B10 Optimisizing patient care through the Acute Medical Unit with expanded nursing practice Marian Ryan Lifestyle & Health AMU UHL Dooradoyle B11 Ms A Systematic Review of the Surgical and Rehabilitative Outcomes of Hip Arthroscopy in Athletes with Femoroacetabular Impingement Danielle LovettCarter Lifestyle & Health GEMS, UL A Jawanda A Hennigan B12 The cellular and molecular consequences of Ms maternal immune activation on the development of the rodent spinal cord. Rebecca Anderson Lifestyle & Health GEMS, UL RC Anderson FC Clarke ID Presentation Title B02 Predictors of health of pre-registration nursing and midwifery students: Findings from a cross sectional survey B04 Changing Physical Activity Behaviour in People with Multiple Sclerosis: A Review B05 Title Author Category Dept /Org T Foley Co-Author 6 Co-Author 7 S Gallagher J Radford J-M K GW Fitzpatrick O’Keeffe KW Mcdermott Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: TECHNOLOGY & HEALTH ID Presentation Title Title C01 Medical Device Software Process Improvement: A Perspective from a Medical Device company Connected Health: Software, Quality and Processes Ms Marie Travers Technology & Health Lero, UL Dr Noel Carroll Technology & Health ARCH - Applied Research I Richardson The Influence of Biological Content on the Fracture Toughness of Femoral Plaque Tissue Dr C07 Hyaluronic Acid Scaffold Coatings for Diagnostic Applications Ms Fernanda C08 Clinical audit: The appropriate use of CT pulmonary angiography in patients with suspected pulmonary embolism Developing a system wide hospital tool to inform Hospital escalation status Ms Mary Ann Peters Technology & Health Dr Marie Casey Technology & Health Dept of Public Health McNamara, D Fitzgerald, T Helicopter Emergency Aeromedical Service Mr Support to the National Ambulance Service, Ireland: report on a pilot project Darren Figgis Technology & Health Emergency Aeromedical P Moran D Gaumont K Henry P Traynor D Hennelly C O’Donnell A Case of Pickwickian Syndrome: Use of An Dr Extra Corporeal CO2 Removal Device vs. targeted weight loss therapy Dr A New Age of Idiopathic Dilated Cardiomyopathy: Exploration and Development of a Genetic Consensus Case report Endomyocardial fibroelastosis. Dr Nam N Yashpal A O’Brien S O’Riain C M Nix C02 C06 C09 C10 C11 C12 C13 C14 C15 Author Category Dept /Org Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 Dr I Richardson Co-Author 6 for Connected Health Technology Centre, Dept of CSIS, UL Eoghan Cunnane Technology & Health Centre for Applied Barrett H.T Engineering Research, MSSI, and Mechanical, Aeronautical & Biomedical Eng Dept, UL Characterisation of the functions of Bovine Mr Serum Albumin in the culture of NS0 cells producing human therapeutic monoclonal antibodies Mr Validation of the activPAL3 micro Zamboni Technology & Health Stokes Laboratories, UL Kavanagh E.G Mongrain R Walsh M.T MN Collins Service, National Ambulance Service Yashpal Technology & Health Dept of Anaesthesia & S Mahdy Critical Care, UHL Cormac O Connor Technology & Health Dept of Cardiology, UHL CT O’Connor ME D O’Hare O’Callagha n TJ Kiernan Khalid Mostafa Liam Ahmed Technology & Health Cardiology Dept, UHL V.Voon Prof. T.Kiernan L McNamara D Buckley A.Abbas U.Azhar B. Carson A. Donnelly Cormac McNamara Technology & Health Life Sciences/Stokes Institute Powell Technology & Health Dept of Physical Education and Sport Sciences, UL K. Dowd M Osbourne T Dalton M.Ayyaz P Kiely Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: TECHNOLOGY & HEALTH (continued) ID Presentation Title C16 Effectiveness of Age- Adjusted D- Dimers in Mr Ruling out Pulmonary Embolism Amritpal Development of a Quality Performance Measurement System for a Radiology Department Marti C17 C18 Title Ms Author Jawanda Category Dept /Org Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 Technology & Health UL Graduate Entry Medical Program Lotter Technology & Health Radiology Dept, UHL, Diagnostic Directorate, HSE and Lero - the Irish Software Engineering Research Centre Dept of CSIS, UL Dr Ita Richardson Dr Louise Reid B. Dunleavy P. O’Byrne Mr Turning Data into an Organisational Asset for Healthcare, This project is about turning data collected at the point of patient care into information and knowledge to monitor, evaluate and plan epilespy services in Ireland. Dr Software Development of Prototype Colorectal Cancer Database Michael Fitzsimons Technology & Health 3rd Year Medical Student, Graduate Entry Medicine, UL M. Dunne Kevin Lally Technology & Health Colorectal Surgery, UHL C Coffey C21 Towards the Characterisation of Carotid Artery Plaque Toughness: An Application for Cutting Balloon Angioplasty Hilary Barrett Technology & Health Centre for Applied C22 CORRELATING URETHRAL RUPTURE WITH DISTENSION OF THE URETHRA DURING THE INFLATION OF A MISPLACED TRANSURETHRAL CATHETER BALLOON C23 Deciphering mechanisms that drive Breast Cancer Metastasis to Bone C25 A Preliminary Study to Determine if a Particular Arteriovenous Fistula Configuration can Generate Helical Flow in an Arteriovenous Fistula and if Helical Flow is a Surrogate Marker of Exposure to Disturbed Shear Primary care practitioner’s perspectives on Mr the challenges for adopting remote patient technology and its impact for the Irish Health System Ms Central Venous Stenosis associated with Haemodialysis Access; A Systematic Review C20 C27 C29 Ms Co-Author 6 E.M. Cunnane Biomedical Engineering Research (CABER), MSSI, UL Ms Rachel Calahane Technology & Health Centre for Applied Connor V Engineering Research, Cunnane MSSI, and Mechanical, Aeronautical & Biomedical Eng Dept, UL Ms Anushree Dwivedi Technology & Health Dept. of life Sciences, D Hoey, Faculty Of Science and Engineering Technology & Health Dept of Mechanical, Mr Connor Cunnane Aeronautical & Biomedical Eng, UL Myles Gardiner Technology & Health E-Health Three Ireland M,Gardiner Sinead Morley Technology & Health MABE, UL D Newport Dr Bryan Kenny M. Fitzsimons N. Delanty John A Thornhill E.G. Kavanagh M.T. Walsh Niall F Davis Eoghan M Cunnane Rory O’C Mooney S Broderick M Walsh P A Kiely L Browne M Walsh Michael T Walsh Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH Author Category Dept /Org Ryan Clinical Research Respiratory Dept, ULHG. Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 Ryan, P O’Brien, A Casserly, B William Anthony Moynihan Clinical Research X-RAY DEPT, UHL L Bowden Mr. Hal Cavus Clinical Research Dept of Psychology, Education and Health Sciences, UL R M Msetfi Dr Hamid Yousuf Clinical Research Gastroenterology, UHL U sharif A Sulaiman I ul Haq Mr Ronan Callanan Clinical Research Year 4 Medical Student, UL GEMS D Ryan L Hickey Ms Sanskriti Sasikumar Clinical Research Medical Student, ULGraduate Entry Medicine Iain Feeley MBBS MRCS Dorathy Niall MBBS MCh FRCS Mrs Maura Cleary Clinical Research Physiotherapy F Steed J Saunders ID Presentation Title Title D02 Adherence to Long Term Oxygen Therapy for Chronic Obstructive Pulmonary Disease patient’s in the HSE mid-western area. A comparison of Test Bolus at 100 KVP versus Bolus Tracking at 120 KVP of Multidetector CT Pulmonary Angiography protocols (CTPA) in a 64 slice scanner. Judgements of contingency under cognitive load: The role of available cognitive capacity in feelings of control, learned helplessness and hopelessness Adequacy of bowel preparation in patients undergoing inpatient and outpatient colonoscopy: Results of a single center audit A retrospective cohort study on the suitability of the empirical antibiotic treatment of sepsis in University Hospital Limerick Emergency Department. Does knee flexion in the post operative period following total knee arthroplasty reduce blood loss resulting from the procedure: A systematic review of the literature Multifactorial Falls Prevention programme, A Collaboration between UL Hospitals, Nenagh Hospital and Network 9 PCCC Ms Paula Mr D03 D04 D05 D06 D07 D08 P Kiely Co-Author 6 JM O Brien M Ahmed M Skelly D09 Rivaroxaban- A cost effective alternative to Prof Michael Warfarin in the treatment of provoked DVT. Watts Clinical Research Dept. Medicine, UHL Emma Groarke William Courtney Jane Conway Deborah Burke Jean Saunders Denis O’Keeffe D10 TREATMENT FREE REMISSION IN CHRONIC MYELOID LEUKAEMIA - A NEW GOAL: IS THIS POSSIBLE IN IRELAND (ROI)? Groarke Clinical Research Dept of Haematology, UHL EM Groarke S Langabeer D O’Keeffe M Leahy M Ryan Dr Emma H O’Leary Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 5 2 E Groarke L O'Brien M Kiely S Joyce J Gleeson Co-Author 6 H O’Leary Dept of Haematology, UHL Emma Groarke Tariq Joanne Nally Maeve Leahy Hilary Mohamme O'Leary d Abkur Denis O’Keeffe 1. Rheumatology Dept, UHL, Limerick 2.GEMS, Limerick 1. Rheumatology Dept, UHL, Limerick 2. GEMS, Limerick Fahd Adeeb Wan Lin Austin Stack Joe Devlin Fahd Adeeb Shakeel Anjum Philip Hodnett Clinical Research 1. Rheumatology Dept, UHL, Limerick 2. GEMS, Limerick Fahd Adeeb Conall WR Conrad V Fitzgerald Timon Coughlan Clinical Research Dept of Cardiology, UHL JJ Coughlan H Yagoub Prof T Kiernan Miss Ceara Rice Clinical Research H O’Connell Mr Cullinane Clinical Research Mrs Berbie Swelling, Erythema and Induration in the Genitalia of Pediatric Patients? Think of Metastatic Crohn’s Disease –Delay in diagnosis can cause significant morbidity Byrne Clinical Research 4th year medical student, M Leonard presenting on behalf of the Psychiatry Research Dept UL Dept of Clinical M O’Keeffe Therapies, Faculty of Education & Health Sciences, UL, Limerick, Ireland Dermatology Dept, UHL M Lynch CLOGGED UP! Wong Clinical Research Dept of Medicine, UL Group of Hospitals (St John’s Hospital, Limerick) CEARA RICE ID Presentation Title Category Dept /Org D11 Dr STREAMLINING THE MANAGEMENT OF BLOOD GROUP O RH NEGATIVE BLOOD STOCK: A SINGLE CENTRE IRISH EXPERIENCE Dr FIVE CASES OF PNEUMOCYSTIS PNEUMONIA (PCP) INFECTION IN PATIENTS FOLLOWING TREATMENT WITH BENDAMUSTINE / RITUXIMAB: PROPHYLAXIS SHOULD BE CONSIDERED AS STANDARD PRACTICE Behcet's disease in Ireland: Patient Access Dr and Response to Biologics Emma Groarke Clinical Research Dept of Haematology, UHL Emma Groarke Clinical Research Fahd Adeeb Clinical Research Dr Resolution of Deep Variant Morphea (Morphea Profunda): A case series of three patients successfully treated with Abatacept (Orencia) SIGNIFICANT LARYNGEAL DESTRUCTION IN Dr A NORTHERN EUROPEAN COHORT OF BEHÇET’S DISEASE PATIENTS Fahd Adeeb Clinical Research Fahd Adeeb PPCI with large volume thrombus burden: The Angiojet Experience at UHL Performance on a Novel Test of Attention (‘The Lighthouse Test’) Amongst Elderly Medical Outpatient Attendees Dr JJ D18 Measuring Physiotherapist’s Verbal Communication During a Chronic Low Back Pain Consultation: A Cross-Sectional Observational Study D19 D20 D12 D13 D14 D15 D16 D17 Title Dr Author Paul Eleanor EITHNE MULLOY Joe Devlin Alexander Duncan Fraser Alexander Duncan Fraser Neville P Shine Joseph P Hughes Alexander D Fraser1 C Exton M Melville C Dunne D Meagher D Wall K Ahmed B Ramsay K O’Sullivan L Roche Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) ID Presentation Title Title D21 Development of a Novel Test of Visuospatial Cognition: The Letter and Shape Drawing Test. A study of performance in Hospitalised Elderly Patients and Young Healthy Adults An Audit of Paediatric Service Utilisation in Primary Care by Funding Scheme Radiation Doses from Radiological Investigations: Is there a need for formal education? The context, causes and consequences of falls in people with Multiple Sclerosis: Preliminary results from an Irish crosssectional study Renal Infarction Secondary To Spontaneous Renal Artery Dissection: A Case Report Dr Debbie Mr D22 D23 D25 D26 D27 D28 D29 D30 D31 Prevalence of significant hepatic fibrosis and cirrhosis assessed by the NAFLD Fibrosis Score in patients attending the diabetic clinic One-Stage V s Two-Stage Brachio-Basilic Arteriovenous Fistula for Dialysis: A Systematic Review and a Meta-Analysis Role of Far Infra-Red therapy in dialysis Arterio-venous Fistula maturation and survival: Systematic review and metaanalysis Effects of neck radiation therapy on extracranial carotid arteries atherosclerosis disease prevalence: Systematic Review and a Meta-analysis The use of arteriovenous fistulae as an adjunct to peripheral arterial bypass: A systematic review and meta-analysis. Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author Co-Author 5 6 2 D Adamis A Hannigan CP Dunne OA Williams M Leonard C Exton Category Dept /Org White Clinical Research Dept of Anaesthetics, University Hospital Galway Bradley Taylor Clinical Research UL – GEMS Dr Cormac O Connor Clinical Research C/O Ms Nuala Lynch, HSE Bowden L West Lynch N O’Brien J Ms Laura Comber Clinical Research Dept of Clinical Therapies UL L Comber R Galvin S Coote Mr Zeshan Siddiqui Clinical Research Y4 Medicine, GEMS UL Wu Z Siddiqui Z Smith C Mr Zeshan Siddiqui Clinical Research Y4 Medicine, GEMS UL Chin JL Chan G Sin PS Mr Khalid Bashar Clinical Research Dept of Vascular Surgery, D. A. Healy UHL Mr Khalid Bashar Clinical Research Mr Khalid Bashar Mr Thomas Aherne Author Taylor B Co-Author Co-Author 8 7 D Meagher Morrissey P Siddiqui Z O’Rathallai Aftab A gh E Courtney G McGurk C S. Elsheikh L.D. Browne M.T. Walsh M.Clarke – P.E. Burke Moloney E. G. Kavanagh Dept of Vascular Surgery, L.D. Browne UHL E. A. H. M.T. Walsh Kheirelseid M.Clarke – Moloney P.E. Burke S.R. Walsh Clinical Research Dept of Vascular Surgery, D.Healy UHL M.ClarkeMoloney P.Burke E.Kavanagh S.R. Walsh Clinical Research Dept of Vascular Surgery, T. Maloney UHL P. Burke E Kavanagh P. Naughton E.G. Kavanagh S.R. Walsh Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) ID Presentation Title Category Dept /Org D33 Ms Sonographic features of thyroid nodules; diagnostic accuracy. Ms Thyroid FNA guidelines; a comparison of the six international recognised guidelines. Arlene Weir Clinical Research GEMS, UL. Arlene Weir Clinical Research GEMS, UL. Dr. Declan Sheppard An audit of MRI lumbar spine for detection Dr of suspected Cauda Equina Syndrome. A comparison of carotid and femoral arterial Dr plaque composition and correlation with clinical details for consecutive patients that underwent endarterectomy at University Hospital Limerick 2012-2014 Padraig Kelly Clinical Research Sligo General Hospital P Hession Mairead Hennessy Clinical Research Dept of Vascular Surgery, MM UHL Hennessy EM Cunnane EG Kavanagh MT Walsh Carotid Endarterectomy – a single centre experience The effects of a group Shoulder Exercise Class: a qualitative and quantitative evaluation 5-α-Reductase Deficiency in Two Siblings: A Case Report Cork City Marathon Research Study Mr Adeel Zafar Syed Clinical Research Vascular Surgery, UHL Zafar A Boyle E Gowey A Dr Karen McCreesh Clinical Research Dept of Clincial Therapies Hayes A Conroy C Kelleher M Ms Ivana Capin Clinical Research GEMS UL Dr. M Ryan Mr Cian O Brien Clinical Research Dept. of Epidemiology & Public Health UCC Prof. John Browne Dr. Niamh Cummins D41 An outbreak of extended spectrum betalactamase-resistant Escherichia coli in an Irish neonatal intensive care unit. Dr Ciara O Connor Clinical Research D42 Dr A case of infective endocarditis in endstage kidney disease mediated by daptomycin-resistant, vancomycin-resistant enterococci. Mr. DERIVATION OF THE CT HEAD RULE FOR EMERGENCY DEPARTMENT SYNCOPE PATIENTS Ciara O Connor Clinical Research Clinical Microbiology C O’Connor Specialist Registrar, Dept of Clinical Microbiology, UHL. Clinical Microbiology C O’Connor Specialist Registrar, Dept of Clinical Microbiology, UHL. Dr. AnneMarie O’Flynn R Philip J. Viau (BA, Alexander MA) Clinical Research D34 D35 D36 D37 D38 D39 D40 D43 Title Author Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 Dr. Declan Sheppard P Boers R Philip LF Casserly L Power Graduate Entry Medicine M Mukarram K Arcot School, UL (2 nd year) Co-Author 6 Dr. V Thiruganasa mbandamoor thy Abdularahim Kavanagh E Burke P O L Power NH O’Connell CP Dunne C Finnegan NH O’Connell CP Dunne Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 5 2 Shack, M Ryan, D Co-Author 6 GEMS, UL S.M. Sahebally P.N. Faul P.A. Kiely Clinical Research GEMS, UL H O’Driscoll G MC Cormack Kinsella Clinical Research GEMS student Austin G. Stack Eimear O Neill Clinical Research UHL, 4th year Graduate entry into Medicine, UL Ms Gillian Quinn Clinical Research Physiotherapy Dept, St. Dr. S. Coote Vincent’s University Hospital, Dublin, Clinical Therapies Dept, UL Cormac O Connor Clinical Research Dept of Cardiology, UHL CT O’Connor M TJ Kiernan Gorenchtei n Karen McCreesh Clinical Research Dept of Clinical Therapies, UL E Barrett D52 Through the Looking Glass: The Integration Dr of Intracoronary Optical Coherence Tomography in an Irish Tertiary referral Centre Dr Is Thoracic Spine Posture Associated with Shoulder Pain, Range of Motion and Function? A Systematic Review. Dr Get SMART, Write it Down! Ari Damla Clinical Research UHL, Urology Intern D Ryan D53 Audit of Radiological Investigation of Renal Dr Ari Damla Clinical Research UHL, Urology Intern D Ryan Cliodhna Ni Mhurchu Clinical Research UL GEMS ID Presentation Title Title D44 An Audit of Venothromboembolism Prophylaxis in Lower Limb Immobalisation Relationship of mesenteric disease manifestations in Crohn's disease with mucosal and systemic manifestations. Retrospective Audit of the Utilization of Infliximab in Inflammatory Bowel Disease Patients at a Single Centre over a 10-year Period Prevalence and correlations of Inappropriate Prescribing Practice (PIP) in Chronic Kidney Disease; a Multi-Centre Irish study Anti-coagulation: A study of the prescription preferences of general practitioners and an audit comparing the usage of novel anti-coagulant drugs versus warfarin in the primary care setting. Assessing the Predictive Validity of the TUG, Timed Up and Go test, and a Questionnaire to Determine the Risk of Falling in People with Multiple Sclerosis. Ms D45 D46 D47 D48 D49 D50 D51 D54 Colic in UHL ED Department Carbon monoxide toxicity as a primary or contributory cause of death: an observational study of cases in forensic medicine. Author Category Dept /Org Shack Clinical Research UL, GEMS Miss Miranda Kiernan Clinical Research Miss Hannah O Driscoll Mr Michael Ms Melissa F. Shanahan C. Dunne J.C. Coffey Mohamed E. Elsayed Muhammad Sibéal Nic Umair Sharif Suibhne John Ferguson L. Comber Dr. C. McGuigan M O’ Keeffe K O’ Sullivan K McCreesh J Lewis Co-Author 7 Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) ID Presentation Title Title D55 Case Series of Patients Diagnosed With Cervicogenic Vertigo – an unfamiliar complaint. Outcomes for patients with CIN 11 and CIN 111 treated with Cold Coagulation Audit of VTE thromboprophylaxis in UHL and development of a VTE audit tool. Pharmacist contribution to a new oral anticancer medication (OAM) clinic IMPAIRED NITRIC OXIDE MEDIATED VASODILATION IN LACUNAR STROKE Exploring the benefits of oral protein supplementation in gastrointestinal surgery patients: a systematic review Characterising the role of Protein Kinase C in Breast Cancer Nurses experience of supporting patients with a tracheostomy a descriptive qualitative enquiry. Circulating fibrocyte levels in patients preand post-operation. Correlating the expression of Protein Kinase C isozymes with the transformed phenotype in Colorectal Cancer Deciphering the role of RACK1 in regulating MAP Kinase Activity to promote proliferation in Colorectal Cancer Potential role of ultrasound examination in the diagnosis of neonatal fractures A one year follow up and case study, for Faecal Transplant in the Management of Crohn's Colitis with persistent Clostridium Difficile Infection. A retrospective comparison of focused versus Standard Abdominopelvic CT examination in the evaluation of patients with suspected abdominal and pelvic disease. A Case of Idiopathic Primary Pulmonary Hypertension in an 18 year old female, managed at the Acute Medical Assessment Unit at Ennis General Hospital. Miss Ciara D56 D57 D60 D61 D62 D63 D64 D65 D66 D67 D68 D69 D70 D71 Author Category Dept /Org Hennessy Clinical Research UHL– Ear, Nose and Throat Dept. GEMS. Maureen Madden Clinical Research Colposcopy Clinic L Hartigan A Sultan G Reidy K Hickey Mr Eoin Barrett Clinical Research Dept of Pharmacy UHL E Barrett S Nic Suibhne A M Ali B McGee B Stack M Aherne Ms Michelle English Clinical Research Pharmacy Dept, UHL. O Flynn Dr Elaine Shanahan Clinical Research Dept of Therapeutics and P Guilfoyle Aging, G Burke S H Haider , E Moloney H Markus S Jackson Mr Mike Crickmer Clinical Research GEMS – UL Coffey, J.C Dunne, S. Dr Mary McCumiske Clinical Research y Dept. of Life Sciences, UL C.M. Dowling A. Merrigan A. Lal S. Tormey T. Dalton Ms Jane Savage Clinical Research ENT DEPT, UHL Miss Funke Owolabi Clinical Research GEMS, UL Ms Dowling Clinical Research Dept of Life Sciences, and MSSI, UL, Limerick Miss Sheri Hayes Clinical Research Department of Life Sciences, UL Catrìona Dowling Dr Jim Crotty Clinical Research Dept of Radiology, UHL R. Coakley Dr Donal Cahill Clinical Research Medical SHO, UHL Dr M Moloney Dr Donal Cahill Clinical Research Medical SHO, UHL Dr J Crotty Dr Donal Cahill Clinical Research Medical SHO, UHL Dr S Gerraghty Catríona M Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 C O’Rourke J.E Fenton. Crickmer, M Dunne, C.P O’Regan, A M.G. Kiernan P Tibbits Patrick A Kiely Dr T Perice J.C. Coffey Co-Author 6 P.A. Kiely Co-Author 7 Co-Author 8 Co-Author 9 L Kalra C Swift D Lyons Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) ID Presentation Title D72 THE VALUE OF ROUTINE CXRs PERFORMED Dr. IN YOUNG CHILDREN WITH CYSTIC FIBROSIS Ngozi Oketah D73 Bone age assessment in General Paediatric Practice. Is RACK1 able to modulate the translation elongation in cancer? Pain and depressive symptoms in an inpatient palliative care setting: do they overlap? Education and Training at UL Hospitals – the NCHD perspective Immediate response of the supraspinatus tendon to loading in rotator cuff tendinopathy CLINICAL SIGNIFICANCE OF RAISED HAEMATOCRIT LEVELS IN A SINGLE READING: AN APPROACH TO DETERMINING NECESSARY FOLLOW UP Continuous Infusion Ondansetron for the Management of Nausea & Vomiting in Patients Receiving Cisplatin Vitamin D, serotonin regulation and its potential relevance in seasonal affective disorder:A Review Use of the clock drawing test (CDT) for identification and assessment of Delirium in hospitalised patients: a systematic review. 10-year experience of acetabular reconstruction using trabecular metal Delirium in Palliative Care: Investigating the relationship between delirium specific diagnostic features and various cognitive domains Dr Mark O´Rahelly Clinical Research Intern UHL Ms Beatrice Malacrida Clinical Research Dept. of Life Sciences and CM Dowling PA Kiely MSSI, UL, Limerick Dr Mas Mahady Mohamad Clinical Research Cognitive Impairment Research Group, GEMS B Davis M Leonard , F Twomey M Lucey M Conroy Prof Paul Finucane Clinical Research Chief Academic Officer, UL Hospitals E Jennings N Lynch J O’Connor D O’Hare L Rafter Dr Karen McCreesh Clinical Research Dept of Clincial Therapies Donnelly AE Lewis JS Dr Adrian Maraj Clinical Research Dept of Haematology, UHL EM Groarke C Lenihan M Leahy H O'Leary D O'Keeffe Ms Mary Rose Pambid Clinical Research Medicine, UL B. Baadjes J.E. Potts R. Esau S.R. Rassekh Mr Adam Clinical Research GEMS Dr Olugbenga Williams Clinical Research Cognitive Impairment Research Group, UL GEMS H O’Connell M Leonard D Adamis Gorenchtei Clinical Research n GEMS, UL FE Rowan F Condon Davis Cognitive Impairment M Mohamad M Leonard M Lucey Research Group (CIRG), Dept of Psychiatry, GEMS (GEMS). D74 D75 D76 D77 D78 D79 D80 D81 D82 D83 Title Author Mike Miss Brid O Brien Category Dept /Org Clinical Research Paediatric Respiratory Dept. UHL Clinical Research Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 D.T. McHugh N. Power C. Lynch B. Linnane N Bussmann B Jamal, Co-Author 6 Co-Author 7 K Ryan D Meagher AM Murphy D Meagher F Twomey M Conroy D Meagher Co-Author 8 Co-Author 9 Co-Author 10 POSTER PRESENTATION: CLINICAL RESEARCH (continued) ID Presentation Title Title D84 A study of depressive symptoms in hospitalised elderly medical patients with and without neurocognitive disorders An Audit of Preoperative Fasting in UHL Dr Mas Mahady Mohamad Dr Cathal MacDonnc Clinical Research ha Anaesthesia, University Hospital Galway Title: Development of an abbreviated version of the Cornell Scale for Depression in Dementia (CSDD) for use in detection of depressive illness in elderly hospitalized patients. Severity of Sleep Apnea in the Obese Population: Does Hypoventilation Syndrome make a Difference Geriatric Urology:an evolving subspeciality with increasing workload Is testicular pain and vomiting pathognomonic for testicular torsion in pubertal boys? Implications for lay and medical education. Case series , development of second malignancies after receiving Bortezomib for Multiple Myeloma Dr Ahmed Abba Aji Clinical Research Adult Mental Health Services Dr Tyler Hynes Clinical Research Dr Joana Leao Mr Dr D85 D86 D88 D89 D90 D91 Author Category Dept /Org Clinical Research Cognitive Impairment Research Group, GEMS Co-Author 1 Co-Author Co-Author 3 Co-Author 4 Co-Author 2 5 M Leonard J S McInerney M O’Connor BA Davis McFarland J O’Dea N Kiernan–McC onnell Henry David O’Connell J.Meagher Paul Reynolds Dept of Respiratory Medicine Chong SC Saleem S. Casserly B Clinical Research Dept of Urology Francis S Aslam A Flood HD Asadullah Aslam Clinical research Dept of Urology Kelly NP Domanska Giri SK K Mohamed Mohamed Bakri Clinical research Dept of Haematology, UHL Dr. MR Ryan Dr. H O’Leary Mas Mohamad Giri SK Flood HD Co-Author Co-Author Co-Author 6 7 8 P Reynolds AM Meaney D Adamis Anna Maria Alaba Meaney Olugbenga Williams Co-Author 9 C Condon Co-Author 10 C Dunne