Dr. Astrid Tannert Position Professional Appointments Education

Dr. Astrid Tannert
Leibniz Institute for Zoo & Wildlife Research
Department of Reproduction Biology
phone: +49 (0)30 5168 341
Fax:
+49 (0)30 5126 104
email: [email protected]
Position
Scientist
Research interests: cryopreservation processes, cellular imaging
Professional Appointments
since 2013
Scientist at the Leibniz Institute for Zoo and Wildlife Research
Research focus: improvement of cryopreservation processes
2008 – 2012
Scientist at the Rudolf-Boehm-Institute for Pharmacology and Toxicology at the
University Leipzig
Research focus: elucidation of signal transduction processes and cell motility using
cellular imaging
2006 – 2008
PostDoc at the Institute for Pharmacology at the Charité Berlin
Research focus: elucidation of signal transduction processes using new FRAP
approaches and cellular imaging
2004 – 2005
PostDoc at the group “Protein folding & Aggregation” at the Fritz-LipmannInstitute for Age Research in Jena
Research focus: influence of “raft-lipids” on cellular amyloid formation
2003 – 2004
PostDoc at the group “Molecular Biophysics” at the HU Berlin
Research focus: interaction of seminal plasma proteins with membranes
Education
2000 – 2003
PhD thesis at the group “Molecular Biophysics” at the HU Berlin
Title: Mechanisms generating bilary lipid specificity”,
”
1994 – 2000
Study of Biochemistry, Martin-Luther-University Halle-Wittenberg,
University of Wales – College of Cardiff (UK) and Free University Berlin
Teaching Activities
Lecture “Conservation of sperm cells and genome banking”
Seminars in Pharmacology and toxicology” for human medicine students
”
Lecture “Pharmacodynamics”
Course “Emergency medicine” for human medicine students
Practical Molecular cell biology”
”
Memberships
“Gesellschaft für Biochemie und Molekularbiologie e. V.” (GBM) , EMBO
Publications
Klein AS, Tannert A, Schaefer M (2014). Cholesterol sensitises the transient receptor
potential channel TRPV3 to lower temperatures and activator concentrations. Cell
Calcium 55:59–68.
Tannert A, Schaefer, M (2012). High Throughput and Content Screening/Screening
for New Pharmaceuticals. In: Handbook of Biophotonics: Vol. 3: Photonics in Pharmaceutics, Bioanalysis and Environmental Research by Jürgen Popp, Valery V. Tuchin,
Arthur Chiou, Stefan H. Heinemann (eds).
Klein AS, Schaefer M, Korte T, Herrmann A, Tannert A (2012). HaCaT keratinocytes exhibit a cholesterol and plasma membrane viscosity gradient during directed
migration. Exp. Cell Res. 318:809-818.
Bachem A, Güttler S, Hartung E, Ebstein F, Schaefer M, Tannert A, Salama
A, Movassaghi K, Opitz C, Mages HW, Henn V, Kloetzel PM, Gurka S, Kroczek
RA (2010). Superior antigen cross-presentation and XCR1 expression define human
CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J. Exp. Med.
207:1273-1281.
Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A (2009). Localisation
of endothelin B receptor variants to plasma membrane microdomains and its effects
on downstream signalling. Mol. Membr. Biol. 26:279-292.
Kofler M, Schuemann M, Merz C, Kosslick D, Schlundt A, Tannert A, Schaefer
M, Lührmann R, Krause E, Freund C (2009). Proline-rich sequence recognition: I.
Marking GYF and WW domain assembly sites in early spliceosomal complexes. Mol
Cell Proteomics 8:2461-2473.
Tannert A, Tannert S, Burgold S, Schaefer M (2009). Convolution-based one and
two component FRAP analysis: theory and application. Eur. Biophys. J. 38:649-661.
Tannert A, Voigt P, Burgold S, Tannert S, Schaefer M (2008). Signal amplification between Gβγ release and PI3Kγ-mediated PI(3,4,5)P3 formation monitored by a
fluorescent Gβγ biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleaching analysis. Biochemistry 47:1123911250.
Tannert A, Töpfer-Petersen E, Herrmann A, Müller K, Müller P (2007). The lipid
composition modulates the influence of the bovine seminal plasma protein PDC-109
on membrane stability. Biochemistry 46:11621-11629.
Tannert A, Kurz A, Erlemann KR, Müller K, Herrmann A, Schiller J, TöpferPetersen E, Manjunath P, Müller P (2007). The bovine seminal plasma protein PDC109 extracts phosphorylcholine-containing lipids from the outer membrane leaflet. Eur.
Biophys. J. 36:461-475.
Röcken C, Fändrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig
P, Kähne T, Menard R, Ancsin JB, Bühling F (2006). Cathepsin protease activity
modulates amyloid load in extracerebral amyloidosis. J. Pathol. 210:478-487.
Gellermann GP, Ullrich K, Tannert A, Unger C, Habicht G, Sauter SR, Hortschansky
P, Horn U, Möllmann U, Decker M, Lehmann J, Fändrich M (2006). Alzheimer-like
plaque formation by human macrophages is reduced by fibrillation inhibitors and
lovastatin. J. Mol. Biol. 360:251-257.
Gellermann GP, Appel TR, Tannert A, Radestock A, Hortschansky P, Schroeckh
V, Leisner C, Lütkepohl T, Shtrasburg S, Röcken C, Pras M, Linke RP, Diekmann
S, Fändrich M (2005). Raft lipids as common components of human extracellular
amyloid fibrils. Proc. Natl. Acad. Sci. U S A. 102:6297-6302.
Tannert A, Pohl A, Pomorski T, Herrmann A (2003). Protein-mediated transbilayer
movement of lipids in eukaryotes and prokaryotes: the relevance of ABC transporters.
Int. J. Antimicrob. Agents 22:177-187.
Tannert A, Wüstner D, Bechstein J, Müller P, Devaux PF, Herrmann A (2003).
Aminophospholipids have no access to the luminal side of the biliary canaliculus: implications for the specific lipid composition of the bile fluid. J. Biol. Chem. 278:4063140639.
Buton X, Herve P, Kubelt J, Tannert A, Burger KN, Fellmann P, Müller P, Herrmann
A, Seigneuret M, Devaux PF (2002). Transbilayer movement of monohexosylsphingolipids in endoplasmic reticulum and Golgi membranes. Biochemistry 41:13106-13115.
Marx U, Lassmann G, Holzhütter HG, Wüstner D, Müller P, Höhlig A, Kubelt J,
Herrmann A (2000). Rapid flip-flop of phospholipids in endoplasmic reticulum membranes studied by a stopped-flow approach. Biophys. J. 78:2628-2640.