Heart and Stroke Foundation Research Report 2007-2008
Transcription
Heart and Stroke Foundation Research Report 2007-2008
Research Report | RAPPORT DE RECHERCHE 2006-2007 www.hsf.ca/research Cover Photo: Dr. James M. Christenson (British Columbia Ambulance Service) works with a team funded in 2006-2007 through an award titled Proposal to create a Canadian collaborative RCC. The award is part of the Federation Research Fund’s Resuscitation Outcomes Consortium 2004 initiative. Photo de la page couverture : Dr James M. Christenson (Service ambulancier de la Colombie-Britannique) travaille avec une équipe établie en 2006-2007 grâce à une bourse de recherche intitulée Proposal to create a Canadian collaborative RCC. La bourse fait partie du Fonds de recherche de la Fédération dans le cadre de l’initiative Consortium sur les retombées de la réanimation 2004. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 MISSION MISSION The Heart and Stroke Foundation, a volunteer-based health charity, leads in eliminating heart disease and stroke and reducing their impact through the advancement of research and its application, the promotion of healthy living, and advocacy. Organisme bénévole de bienfaisance en santé, la Fondation des maladies du cœur mène la lutte vers l’élimination des maladies du cœur et des accidents vasculaires cérébraux (AVC), en contribuant activement à l’avancement de la recherche et sa mise en application, à la promotion de modes de vie sains et à la représentation auprès des instances responsables des politiques de santé. The Heart and Stroke Foundation is a federation of 10 provincial Foundations, led and supported by a force of more than 140,000 volunteers. For more than 50 years, Canadians have looked to the Heart and Stroke Foundation to fund research that will reduce their risk of cardio- and cerebrovascular disease and improve the quality of their lives. The Foundation has met that challenge. In the last 50 years, the Heart and Stroke Foundation has invested more than $1 billion in heart and stroke research. The mortality rate from heart disease and stroke has decreased in Canada by 70% since 1952, thanks in large part to our research. However, there is still so much more to do. More than 50,000 strokes and 75,000 heart attacks occur in Canada every year. At least one in three deaths annually is due to heart disease and stroke. Cardio- and cerebrovascular disease remains the leading cause of death in Canada and world-wide. In 2006-2007, the Heart and Stroke Foundation invested over $50 million in peer-reviewed research at medical institutes, universities, and hospitals across the country. Our shared goal: to eliminate heart disease and stroke and improve the quality of life for thousands of Canadians affected by these conditions. Every research project highlighted in this report contributes to achieving this vision. La Fondation des maladies du cœur est une fédération regroupant 10 fondations provinciales dirigées et appuyées par une force de plus de 140 000 bénévoles. Depuis plus de 50 ans, les Canadiens et les Canadiennes se tournent vers la Fondation des maladies du cœur afin de financer la recherche visant à réduire les risques associés aux maladies du cœur et aux accidents vasculaires cérébraux (AVC) et à améliorer leur qualité de vie. La Fondation a relevé ce défi. Au cours des 50 dernières années, la Fondation des maladies du cœur a investi plus d’un milliard de dollars en recherche sur les maladies du cœur et les AVC. Le taux de mortalité attribuable aux maladies du cœur et aux AVC a diminué de 70 % au Canada depuis 1952, en grande partie grâce à nos recherches. Il reste cependant encore beaucoup à faire. Chaque année, plus de 50 000 AVC et 75 000 crises cardiaques surviennent encore au pays et au moins un décès sur trois est attribuable aux maladies du cœur et aux AVC. Les maladies du cœur et les AVC demeurent la principale cause de mortalité au Canada et dans le monde entier. En 2006-2007, la Fondation des maladies du cœur a investi plus de 50 millions de dollars dans la recherche évaluée par les pairs, effectuée dans les instituts médicaux, les universités et les centres hospitaliers du pays. Notre objectif consiste à éliminer les maladies du cœur et les AVC et à améliorer la qualité de vie des milliers de Canadiens et de Canadiennes qui en sont affectés. Chaque projet de recherche mentionné dans ce rapport 00contribue à la poursuite de cette vision. i Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 TABLE OF CONTENTS TABLE DES MATIÈRES MESSAGE FROM THE CHAIR, RESEARCH POLICY AND MESSAGE DU PRÉSIDENT DU COMITÉ CONSULTATIF SUR PLANNING ADVISORY COMMITTEE........................................ 1 LES POLITIQUES ET LA PLANIFICATION DE LA RECHERCHE... 1 1PURPOSE AND SCOPE....................................................... 2 1OBJECTIFS ET PORTÉE...................................................... 2 2SUMMARY TABLES.............................................................. 3 2TABLEAUX SOMMAIRES..................................................... 4 3 RESEARCH FUNDING OVERVIEW.................................... 8 3SURVOL DU FINANCEMENT DE LA RECHERCHE......... 8 3.1 Research Roles.......................................................... 8 3.1 3.2Scientific Review Process......................................... 8 3.2Processus d’examen scientifique............................ 8 3.3 Research Enterprise Components.......................... 9 3.3 3.4 Investments across Health Research Themes..... 10 3.4Investissements dans les quatre thèmes de 4 2006-2007 RESEARCH FUNDING BY PROGRAM.......... 12 4.1 Federation Research Fund..................................... 12 4.2 National Personnel Awards................................... 15 4.2.1Heart and Stroke Foundation Prestigious Awards...................................... 18 4.3 Grant-in-Aid............................................................. 19 4.4Province-specific Research Initiatives................... 23 Rôles dans la recherche........................................... 8 Éléments de l’entreprise de recherche ................. 9 la recherche en santé.............................................. 10 4FINANCEMENT DE LA RECHERCHE PAR PROGRAMME POUR 2006-2007................................................................. 12 4.1 Fonds de recherche de la Fédération.................. 12 4.2 Bourses de fonctionnement nationales............... 15 4.2.1Prix prestigieux de la Fondation des maladies du cœur........................................ 18 4.4.1Provincial Personnel Awards...................... 23 4.3Subvention............................................................... 19 4.4.2 Research Chairs and Professorships.......... 25 4.4 4.4.3Other Provincial Initiatives.......................... 26 4.4.1 Bourses de fonctionnement provinciales.23 4.4.2Chaires de recherche et postes de APPENDIX A: FEDERATION RESEARCH FUND..................... 31 NEW INITIATIVES....................................................................... 34 Initiatives de recherche provinciales..................... 23 professeurs................................................... 25 4.4.3Autres initiatives provinciales..................... 26 Cardiovascular Complications of Diabetes 2007............ 34 Built Environment, Obesity and Health Development Grants 2007 ....................................................................... 35 Reducing Health Disparities Interdisciplinary Capacity ANNEXE A : FONDS DE RECHERCHE DE LA FÉDÉRATION.. 31 INITIATIVES NOUVELLES........................................................... 34 Complications cardiovasculaires du diabète 2007......... 34 Enhancement (ICE) Grants 2006....................................... 35 Environnement bâti, obésité et santé 2007..................... 35 Focus on Stroke 5 2006...................................................... 36 Réduire les disparités sur le plan de la santé - CONTINUING INITIATIVES........................................................ 38 Subventions aux équipes interdisciplinaires de Programs of Research................................................................. 38 renforcement des capacités (EIRC) 2006......................... 35 Childhood Obesity Operating Grants 2005.................... 38 Opération AVC 5 2006....................................................... 36 Genomic Medicine and Human Development 2005..... 39 INITIATIVES EN COURS.............................................................. 38 Vascular Health and Dementia Operating Grants 2005... 39 Programmes de recherche......................................................... 38 Vascular Health and Dementia Operating Grants 2004... 40 Bourses de fonctionnement en obésité chez les Addressing Health Care & Health Policy Challenges enfants 2005....................................................................... 38 of Genetic Medicine 2004................................................. 41 Inflammation and Thrombosis 2004................................. 41 Subventions à la santé et à la démence vasculaires 2005.... 39 Molecular and Cellular Imaging 2004.............................. 42 Subventions à la santé et à la démence vasculaires 2004.... 40 Obesity New Emerging Teams (NET) 2004..................... 43 Relever les défis des soins et des politiques de santé Obesity New Emerging Teams (NET) 2003..................... 43 Palliative / End of Life Care 2004...................................... 44 Médecine génomique et développement humain 2005.... 39 de la médecine génétique 2004..........................................41 Inflammation et thrombose 2004.........................................41 iii Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Regenerative Medicine 2004............................................. 45 Imagerie moléculaire et cellulaire 2004...............................42 Resuscitation Outcomes Consortium 2004..................... 45 Équipes en voie de formation sur l’obésité (EVF) 2004....43 Équipes en voie de formation sur l’obésité (EVF) 2003....43 Sex, Gender & Cardiovascular Disease Interdisciplinary Capacity Enhancement 2004............................................. 46 Soins palliatifs et de fin de vie 2004................................. 44 ICRH/HSF New Emerging Teams (NET) 2003................. 47 Médecine régénérative 2004............................................ 45 Chronic Disease New Emerging Teams (NET) 2002....... 48 Consortium sur les résultats de la réanimation 2004..... 45 Gene-Environment Interactions Interdisciplinary Health Amélioration de la capacité de recherche Research Teams (IHRTs) 2002............................................ 49 interdisciplinaire sur le sexe social, le sexe Training Programs....................................................................... 51 biologique et les maladies cardiovasculaires 2004........ 46 Focus on Stroke 4 2005...................................................... 51 Focus on Stroke 3 2004...................................................... 53 Équipes en voie de formation sur les maladies Focus on Stroke 2 2003...................................................... 54 Focus on Stroke 1 2002...................................................... 55 Équipes en voie de formation ISCR/FMC (EVF) 2003.... 47 chroniques (EVF) 2002........................................................ 48 Équipes interdisciplinaires de recherche en santé Andres Petrasovits Scholarship 2004................................ 55 (ÉIRS) sur les interactions entre les gènes et Canadian Tobacco Control Research Initiative 2004...... 56 l’environnement 2002......................................................... 49 Target Obesity Personnel Awards 2004........................... 56 Programmes de formation......................................................... 51 Strategic Training Initiative in Health Research Opération AVC 4 2005....................................................... 51 (STIHR) 2003....................................................................... 58 Strategic Training Initiative in Health Research (STIHR) 2002....................................................................... 60 Opération AVC 3 2004....................................................... 53 Opération AVC 2 2003....................................................... 54 Opération AVC 1 2002....................................................... 55 APPENDIX B: NATIONAL PERSONNEL AWARDS................. 63 La bourse de recherche Andres Petrasovits 2004........... 55 Initiative canadienne de recherche pour la lutte Doctoral Research Awards................................................. 64 Research Fellowships......................................................... 70 New Investigators............................................................... 74 Initiative stratégique de formation en recherche Visiting Scientist.................................................................. 76 Nursing Research Fellowships.......................................... 76 Industry-Supported Research Personnel Awards........... 77 APPENDIX C: GRANTS-IN-AID................................................. 81 contre le tabagisme 2004.................................................. 56 Bourses Objectif Obésité 2004......................................... 56 dans le domaine de la santé (ISFRS) 2003....................... 58 Initiative stratégique de formation en recherche dans le domaine de la santé (ISFRS) 2002....................... 60 ANNEXE B : BOURSES DE FONCTIONNEMENT British Columbia/Yukon..................................................... 82 NATIONALES........................................................ 63 Alberta/Northwest Territories/Nunavut........................... 86 Bourses de recherche au doctorat................................... 64 Saskatchewan . ................................................................... 91 Bourses de perfectionnement en recherche................... 70 Manitoba ............................................................................ 92 Bourses de nouveaux chercheurs..................................... 74 Ontario ................................................................................ 94 Bourse de chercheur invité................................................ 76 Quebec ............................................................................. 116 Bourses de perfectionnement en sciences infirmières.. 76 New Brunswick . ............................................................... 124 Bourses de fonctionnement en recherche financées Nova Scotia ...................................................................... 125 APPENDIX D: RESEARCH CHAIRS AND PROFESSORSHIPS........................................... 127 par l’industrie....................................................................... 77 ANNEXE C : SUBVENTIONS..................................................... 81 Colombie-Britannique / Yukon......................................... 82 Alberta / Territoires du Nord-Ouest / Nunavut............... 86 Saskatchewan...................................................................... 91 iv Manitoba ............................................................................ 92 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 APPENDIX E: OTHER PROVINCIAL INITIATIVES.................. 129 Ontario ................................................................................ 94 British Columbia/Yukon................................................... 130 Québec ............................................................................. 116 Alberta/Northwest Territories/Nunavut......................... 130 Nouveau-Brunswick . ....................................................... 124 Saskatchewan.................................................................... 130 Nouvelle-Écosse............................................................... 125 Manitoba .......................................................................... 130 Ontario............................................................................... 131 Quebec.............................................................................. 133 Nova Scotia....................................................................... 134 Prince Edward Island........................................................ 134 ANNEXE D : CHAIRES DE RECHERCHE ET POSTES DE PROFESSEURS............................................. 127 ANNEXE E : AUTRES INITIATIVES PROVINCIALES................ 129 Colombie-Britannique / Yukon....................................... 130 APPENDIX F: RESEARCH COMMITTEE MEMBERS............. 135 Alberta / Territoires du Nord-Ouest / Nunavut ........... 130 Saskatchewan.................................................................... 130 APPENDIX G: D EFINITION OF HEALTH RESEARCH THEMES............................................................. 141 Manitoba .......................................................................... 130 Ontario .............................................................................. 131 Québec ............................................................................. 133 TABLES Nouvelle-Écosse............................................................... 134 Table 1. Summary Federation-wide and Province-specific Île-du-Prince-Édouard...................................................... 134 Research Funding (2006-2007)....................................... 3 Table 2. Detailed Federation-wide and Province-specific ANNEXE F : MEMBRES DU COMITÉ DE LA RECHERCHE.... 135 Research Funding (2006-2007)....................................... 5 Table 3. Number of National Personnel Awards and ANNEXE G : DÉFINITION DES THÈMES DE LA Investment of Funds (2006-2007)................................. 16 RECHERCHE EN SANTÉ................................... 141 Table 4. HSF National Personnel Awards by Health Research Theme (2006-2007)....................................... 16 Table 5. Number of Grants-in-Aid and Investment of Funds (2006-2007)......................................................... 19 Table 6. HSF Provincial Personnel Awards Funded (2006-2007)..................................................................... 23 TABLEAUX Tableau 1. Sommaire du financement spécifique à la recherche dans l’ensemble de la Fédération et des provinces (2006-2007).......................................... 4 Tableau 2. Détails du financement spécifique à la recherche Table 7. Research Chairs and Professorships (2006-2007)....... 25 dans l’ensemble de la Fédération et des Table 8. Other Provincial Research Initiatives (2006-2007)...... 26 provinces (2006-2007)................................................. 6 Tableau 3. Nombre de bourses de fonctionnement nationales et montants investis (2006-2007).......... 16 Tableau 4. Bourses de fonctionnement nationales de la FMC par thème de recherche en santé (2006-2007)................................................................. 16 Tableau 5. Nombre de subventions et fonds investis (2006-2007)................................................................. 19 Tableau 6. Bourses de fonctionnement des FMC provinciales (2006-2007)........................................... 24 Tableau 7. Chaires de recherche et postes de professeurs (2006-2007)................................................................. 25 Tableau 8. Autres initiatives de recherche provinciales (2006-2007)................................................................. 27 v Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 FIGURES FIGURES Figure 1. HSF Research Funding by Program (2006-2007)....... 9 Figure 1. Financement de la FMC à la recherche, par Figure 2. HSF Research Funding Trends by Program (2002-2007)................................................................... 10 Figure 3. HSF Research Funding by Health Research Theme (2006-2007)...................................................... 11 Figure 4. HSF Research Funding Trends by Health Research Theme (2004-2007)..................................... 11 Figure 5. Federation Research Fund Leveraged Funding (2002-2007)................................................................... 13 Figure 6. Federation Research Fund Funding by Health Research Theme (2006-2007)..................................... 14 Figure 7. Federation Research Fund Funding Trends by Health Research Theme (2004-2007)..................................... 14 Figure 8. National Personnel Awards Funding by Health Research Theme (2006-2007)..................................... 17 Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2002-2007)......................... 17 Figure 10. Number of National Personnel Awards Applications Submitted and Funded by Province/ Territory (2006-2007).................................................. 18 Figure 11. Grants-in-Aid Funding by Health Research Theme (2006-2007).................................................... 20 Figure 12. Grants-in-Aid Funding Trends by Health Research Theme (2002-2007)................................... 20 Figure 13. Number of Grant-in-Aid Applications Submitted by Province/Territory (2002-2007)......... 21 Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2002-2007).................................. 21 programme (2006-2007)...................................................9 Figure 2. Tendances de financement de la FMC à la recherche, par programme (2002-2007).......................10 Figure 3. Financement de la FMC à la recherche, par thème de recherche en santé (2006-2007)...................11 Figure 4. Tendances du financement de la FMC à la recherche, par thème de recherche en santé (2004-2007)........................................................................11 Figure 5. F inancement bonifié du Fonds de recherche de la Fédération (2002-2007)...................................................13 Figure 6. F inancement du Fonds de recherche de la Fédération par thème de recherche en santé (2006-2007)........................................................................14 Figure 7. Tendances du financement du Fonds de recherche de la Fédération par thème de recherche en santé (2004-2007).....................................14 Figure 8. Financement des bourses de fonctionnement nationales par thème de recherche en santé (2006-2007)........................................................................17 Figure 9. Tendances du financement des bourses de fonctionnement nationales par thème de recherche (2002-2007).....................................................17 Figure 10. Nombre de demandes de bourses de fonctionnement nationales présentées et financées par province/territoire (2006-2007)............18 Figure 11. Financement des subventions par thème de recherche en santé (2006-2007)...................................20 Figure 12. Tendances du financement des subventions par thème de recherche en santé (2002-2007)...... 20 Figure 13. Nombre de demandes de subventions présentées par province/territoire (2002-2007)...... 22 Figure 14. Nombre de demandes de subventions financées par province /territoire (2002-2007)....... 22 vi Heart and Stroke Foundation | Research Report 2006-2007 MESSAGE FROM THE CHAIR, RESEARCH POLICY AND PLANNING ADVISORY COMMITTEE As the current Chair of the Research Policy and Planning Advisory Committee (RPPAC), I am proud to present the 2006-2007 Heart and Stroke Foundation (HSF) Research Report. It lists all of the federation’s research investments made from July 1, 2006 to June 30, 2007. Since 1956, HSF has funded research to reduce the burden of cardio- and cerebrovascular disease. Our research funding extends across the prevention-treatment-care continuum and the four health research themes: basic biomedical, clinical, health services/systems, and population health. In 2006-2007, HSF invested over $50 million in research. This was made possible by the generous donations of Canadians from coast to coast to coast. Our investments were further extended by an additional $11 million through the contribution of diverse organizations to partnered research initiatives. I would like to acknowledge the outstanding leadership of Carolyn Brooks as Chair of RPPAC in 2006-2007. Achievements by the expert and dedicated members of RPPAC during her tenure include launching the first three HSF-led strategic Requests for Applications through the Federation Research Fund within the obesity and resuscitation priority areas, completing an environmental scan in stroke, and completing the Personnel Awards Program Review process. Likewise, Dr. Grant Pierce, Scientific Review Committee Chair, and Dr. Heather Arthur, Vice Chair, provided exemplary leadership to over 1,000 volunteer peer reviewers. The expertise and commitment of our scientific and lay reviewers enable HSF to fund the highest standard of scientific excellence. I would also like to thank and congratulate each one of our HSF researchers for the extraordinary work they do to improve the health and quality of life of all Canadians. Looking to the future, the Heart and Stroke Foundation is taking its widely acknowledged leadership role in knowledge generation and application to new levels. The time is past to think of the burden of heart disease and stroke in isolation. This belief is reflected in our strategic priority areas and partnership philosophy. The HSF mission statement articulates our commitment to knowledge transfer and exchange (KTE). For the research enterprise, this will mean integrating KTE strategies, as Fondation des maladies du cœur | Rapport de recherche 2006-2007 MESSAGE DU PRÉSIDENT DU COMITÉ CONSULTATIF SUR LES POLITIQUES ET LA PLANIFICATION DE LA RECHERCHE À titre de président du Comité consultatif pour la planification et les politiques de la recherche (CCPPR), je suis fier de présenter le Rapport de recherche 2006-2007 de la Fondation des maladies du cœur (FMC). Ce rapport énumère l’ensemble des investissements en recherche effectués par la fédération entre le 1er juillet 2006 et le 30 juin 2007. Depuis 1956, la FMC a financé la recherche destinée à réduire le fardeau imposé par les maladies du cœur et les accidents vasculaires cérébraux (AVC). Le financement que nous offrons à la recherche couvre l’ensemble des activités, de la prévention aux traitements et aux soins, ainsi que les quatre thèmes de la recherche : recherche biomédicale fondamentale, recherche clinique, recherche sur les services et systèmes de santé et recherche sur la santé des populations. En 2006-2007, la FMC a investi plus de 50 millions de dollars dans la recherche. Cet investissement a été rendu possible grâce aux généreux dons que nous avons reçus de Canadiens et de Canadiennes de partout au pays. Nos investissements ont été complétés par une somme additionnelle de 11 millions de dollars versée à titre de contribution par divers organismes à des initiatives de recherche effectuées en partenariat. J’aimerais souligner le leadership exceptionnel de Carolyn Brooks à titre de présidente du CCPPR en 2006-2007. Les réalisations des spécialistes et des membres dévoués du CCPPR au cours de sa présidence comprennent notamment le lancement des trois premiers Appels de soumissions stratégiques dirigés par la FMC dans le cadre du Fonds de recherche de la Fédération, portant sur les domaines prioritaires de l’obésité et de la réanimation, l’exécution complète d’un survol environnemental en matière d’AVC ainsi que la conclusion du processus de révision du programme des bourses de fonctionnement. De la même façon, Dr Grant Pierce, président du Comité d’examen scientifique, et Dre Heather Arthur, vice-présidente du même comité, ont guidé de façon exemplaire plus d’un millier d’examinateurs bénévoles dans le cadre du processus d’examen par les pairs. L’expertise et l’engagement de nos examinateurs scientifiques et examinateurs non spécialisés permet à la FMC d’atteindre les plus hautes normes d’excellence scientifique. J’aimerais aussi remercier et féliciter chacun de nos chercheurs de la FMC pour le travail extraordinaire qu’ils ont accompli afin d’améliorer la santé et la qualité de vie des Canadiens et des Canadiennes. En se tournant vers l’avenir, la Fondation des maladies du cœur joue son rôle de chef de file reconnu dans la production du savoir et son 1 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 appropriate, across all HSF research programs, to ensure that research is applied to improve practice and/or policy. application à d’autres niveaux. L’époque où l’on considérait le fardeau des maladies du cœur et des AVC de façon isolée est désormais révolue. Cette croyance se reflète dans nos domaines de priorité stratégique et dans notre philosophie de partenariat. L’énoncé de mission de la FMC exprime notre engagement envers le transfert et le partage des connaissances. Pour l’entreprise de recherche, cela signifie intégrer les stratégies de transfert et de partage des connaissances, comme il convient, dans l’ensemble des programmes de recherche de la FMC afin d’assurer la mise en application de la recherche et l’amélioration de la pratique et des politiques. The content of this report exemplifies the incredible efforts of thousands of individuals toward achieving our mission, and the remarkable possibilities that exist to make a difference in the lives of Canadians and people across the world. Sincerely, Robert Côté, MD Chair, Research Policy and Planning Advisory Committee Le contenu du présent rapport représente les efforts immenses déployés par des milliers de personnes en vue de réaliser notre mission, ainsi que les remarquables possibilités qui nous sont offertes afin de faire une différence dans la vie des Canadiens, des Canadiennes et des personnes du monde entier. Sincèrement, Robert Côté, M.D. Président, Comité consultatif sur les politiques et la planification de la recherche 1. PURPOSE AND SCOPE 1. OBJECTIFS ET PORTÉE The purpose of this report is twofold: L’objectif du présent rapport comporte deux volets : 1. To illustrate the Heart and Stroke Foundation’s (HSF) overall research investments made in 2006-2007 across all research funding programs and initiatives. 1. Illustrer l’ensemble des investissements en recherche effectués par la Fondation des maladies du cœur (FMC) en 2006-2007 dans le cadre des programmes et initiatives de financement de la recherche. 2. To serve as a reference tool for volunteers and staff across the Heart and Stroke Foundation, the research community, other research funding agencies, and academic institutions. This report covers the period from July 1, 2006 to June 30, 2007. It is a snapshot of expenditures in research during that period. The report presents financial and statistical data for new grants and awards made in 2006-2007, as well as continued funding of previously reported multi-year grants and awards. 2 2. Servir d’outil de référence pour les bénévoles et le personnel dans l’ensemble de la Fondation des maladies du cœur, de la communauté scientifique, des autres agences de financement de la recherche et des établissements d’enseignement. Ce rapport couvre la période entre le 1er juillet 2006 et le 30 juin 2007. Il dresse un portrait des dépenses en recherche au cours de cette période. Le rapport présente des données financières et statistiques concernant les nouvelles subventions et bourses accordées en 2006-2007, ainsi que le financement continu accordé précédemment dans le cadre de subventions et de bourses sur plus d’une année. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 2. SUMMARY TABLES Table 1. Summary Federation-wide and Province-specific Research Funding (2006-2007) Foundation Federation-wide Research Initiatives Grant-in-Aid # National Personnel Awards $ # Province-specific Research Initiatives Federation Research Fund $ # $ Personnel Awards # Chairs $ # Total Other $ # $ # $ British Columbia/ Yukon 47 4,107,282 - - - - - - 3 340,000 1 60,000 51 4,507,282 Alberta/ Northwest Territories/ Nunavut 63 3,391,659 - - - - - - 3 333,462 4 20,000 70 3,745,121 Saskatchewan 10 581,500 - - - - 3 13,500 - - - 100,000 13 695,000 Manitoba 21 840,700 - - - - 8 34,000 - - 1 10,000 30 884,700 Ontario 247 20,054,167 - - - - 149 4,262,475 6 630,118 14 5,212,821 416 30,159,581 Quebec 88 1,335,514 - - - - - - - - 15 140,000 103 1,475,514 7 349,160 - - - - - - - - - - 7 349,160 New Brunswick Nova Scotia 10 476,676 - - - - - - - - 1 5,000 11 481,676 Prince Edward Island - - - - - - - - - - 2 12,000 2 12,000 Newfoundland and Labrador - - - - - - - - - - - - - - All Foundations - - 167 4,575,377 129 3,675,352 - - - - - 428,571† 296 8,679,300 493 31,136,658 167 4,575,377 129 3,675,352 160 4,309,975 12 1,303,580 38 5,988,392 999 50,989,334 TOTAL † HSF contributions to the CSN total $3 million (1999-2006) 3 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 2. TABLEAUX SOMMAIRES Tableau 1. Sommaire du financement spécifique à la recherche dans l’ensemble de la Fédération et des provinces (2006-2007) Fondation Initiatives de recherche à l’échelle de la Fédération Subventions # Bourses de fonctionnement nationales $ # Initiatives de recherche provinciales Fonds de recherche de la Fédération $ # $ Bourses # Chaires $ # Total Autres $ # $ # $ Colombie-Britannique / Yukon 47 4 107 282 - - - - - - 3 340 000 1 60 000 51 4 507 282 Alberta / Territoires du Nord-Ouest / Nunavut 63 3 391 659 - - - - - - 3 333 462 4 20 000 70 3 745 121 Saskatchewan 10 581 500 - - - - 3 13 500 - - - 100 000 13 695 000 Manitoba 21 840 700 - - - - 8 34 000 - - 1 10 000 30 884 700 Ontario 247 20 054 167 - - - - 149 4 262 475 6 630 118 14 5 212 821 416 30 159 581 Québec 88 1 335 514 - - - - - - - - 15 140 000 103 1 475 514 Nouveau-Brunswick Nouvelle-Écosse Île-du-Prince-Édouard 7 349 160 - - - - - - - - - - 7 349 160 10 476 676 - - - - - - - - 1 5 000 11 481 676 - - - - - - - - - - 2 12 000 2 12 000 Terre-Neuve-et-Labrador - - - - - - - - - - - - - - Toutes les Fondations - - 167 4 575 377 129 3 675 352 - - - - - 428 571 † 296 8 679 300 493 31 136 658 167 4 575 377 129 3 675 352 160 4 309 975 12 1 303 580 38 5 988 392 999 50 989 334 TOTAL † Contributions totales de la FMC au Réseau canadien contre les accidents cérébrovasculaires – 3 millions de dollars (1999-2006) 4 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Table 2. Detailed Federation-wide and Province-specific Research Funding (2006-2007) Province/Territory Program British Columbia/Yukon Grant-in-Aid Awards (#) Awards ($) 47 4,107,282 Chair in Stroke Research 1 110,000 Chair in Cardiovascular Research 1 160,000 Professorship in Stroke Research 1 70,000 1 60,000 63 3,391,659 4 20,000 Chair in Cardiovascular Research 1 173,462 Professorship in Stroke Research 2 160,000 10 581,500 3 13,500 - 100,000 21 840,700 Total ($) Research Chairs†: Other Provincial Initiatives: Special Initiative: CardioSHARE - Cardiovascular Health and Research Environment Alberta/ Northwest Territories/ Nunavut Grant-in-Aid 4,507,282 Other Provincial Initiatives: Young Investigator Travel Award Research Chairs : † Saskatchewan Grant-in-Aid 3,745,121 Personnel Awards: Summer Student Scholarship Other Provincial Initiatives: Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source Manitoba Grant-in-Aid 695,000 Personnel Awards: B.Sc. Medical Student 4 18,000 Red River College (RRC) Student 4 16,000 Other Provincial Initiatives: R.E. Beamish Award Ontario Grant-in-Aid 1 10,000 247 20,054,167 884,700 Personnel Awards: Distinguished Scientist 6 135,000 31 2,682,475 Clinician Scientist 8 537,000 Research Fellowship 1 47,500 Nursing Post-Doctoral Research Fellowship 3 177,000 Masters Studentship 21 378,000 Summer Student Scholarship 79 305,500 Chair in Cardiovascular Research 5 527,629 Chair in Cardiac Nursing 1 102,489 Program Grant 6 1,240,000 Health Behaviour Research Initiative (GIA) 1 209,242 Stroke Rehabilitation 4 641,039 Age 45+ with Elevated Systolic Blood Pressure 3 757,315 HSF Centre for Stroke Recovery - 1,646,000 HSF/Richard Lewar Centre of Excellence‡ - 600,000 Publication cost - 119,225 30,159,581 Career Investigator Research Chairs†: Other Provincial Initiatives: 5 Heart and Stroke Foundation | Research Report 2006-2007 Province/Territory Program Quebec Grant-in-Aid Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awards (#) Awards ($) Total ($) 88 1,335,514 13 100,000 2 40,000 1,475,514 349,160 Other Provincial Initiatives: Awards of Excellence Training Bursaries New Brunswick Grant-in-Aid 7 349,160 Nova Scotia Grant-in-Aid 10 476,676 1 5,000 Project Grant 1 10,000 Program Funding 1 2,000 12,000 - - - Other Provincial Initiatives: Gregory Ferrier Award Prince Edward Island Newfoundland and Labrador 481,676 Other Provincial Initiatives: Grant-in-Aid SUBTOTAL 703 Federation Research Fund 129 3,675,352 3,675,352 National Personnel Awards 167 4,575,377 4,575,377 Canadian Stroke Network* - 428,571 428,571 TOTAL 999 42,310,034 42,310,034 50,989,334 50,989,334 † For the most part, Research Chair awards are funded by endowments and are partnered with academic / health research institutions. ‡ HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009) * Total $3 million (1999-2006) Tableau 2. Détails du financement spécifique à la recherche dans l’ensemble de la Fédération et des provinces (2006-2007) Province/Territoire Colombie-Britannique/Yukon Programme Subvention Nombre de Montant des bourses bourses ($) 47 Total ($) 4 107 282 Chaires de recherche† : Chaire de recherche sur les AVC 1 110 000 Chaire de recherche cardiovasculaire 1 160 000 Poste de professeur en recherche sur les AVC 1 70 000 1 60 000 63 3 391 659 4 20 000 Chaire de recherche cardiovasculaire 1 173 462 Poste de professeur en recherche sur les AVC 2 160 000 10 581 500 3 13 500 - 100 000 Autres initiatives provinciales : Initiative spéciale : CardioSHARE – Environnement de santé et de recherche cardiovasculaire Alberta/ Territoires du Nord-Ouest/ Nunavut Subvention 4 507 282 Autres initiatives provinciales : Bourse de déplacement pour jeune chercheur Chaires de recherche : † Saskatchewan Subvention 3 745 121 Bourses de fonctionnement : Bourse d’été pour étudiant Autres initiatives provinciales : Le faisceau d’imagerie et de traitement biomédical du Centre canadien de rayonnement synchrotron 6 695 000 Heart and Stroke Foundation | Research Report 2006-2007 Province/Territoire Manitoba Fondation des maladies du cœur | Rapport de recherche 2006-2007 Programme Subvention Nombre de Montant des bourses bourses ($) 21 Total ($) 840 700 Bourses de fonctionnement : Étudiant au baccalauréat en médecine 4 18 000 Étudiant du Collège Red River 4 16 000 Autres initiatives provinciales : Bourse R.E. Beamish Ontario Subvention 1 10 000 247 20 054 167 884 700 Bourses de fonctionnement : Chercheur émérite Chercheur de carrière 6 135 000 31 2 682 475 537 000 Chercheur clinicien 8 Perfectionnement en recherche 1 47 500 Perfectionnement en recherche post-doctorale sur les soins infirmiers 3 177 000 Bourse d’études à la maîtrise 21 378 000 Bourse d’été pour étudiant 79 305 500 Chaire de recherche cardiovasculaire 5 527 629 Chaire de recherche sur les soins infirmiers cardiovasculaires 1 102 489 6 1 240 000 Chaires de recherche† : Autres initiatives provinciales : Subvention de programme Québec Initiative de recherche sur les comportements liés à la santé (subvention) 1 209 242 Réadaptation d’AVC 4 641 039 45 ans et plus avec tension artérielle systolique élevée 3 757 315 Centre de réadaptation d’AVC de la FMC - 1 646 000 Centre d’excellence FMC/Richard Lewar ‡ - 600 000 Coûts de publication - 119 225 88 1 335 514 13 100 000 Subvention 30 159 581 Autres initiatives provinciales : Prix d’excellence 2 40 000 1 475 514 Nouveau-Brunswick Subvention Bourses de formation 7 349 160 349 160 Nouvelle-Écosse Subvention 10 476 676 1 5 000 Subvention de projet 1 10 000 Financement de programme 1 2 000 - - - 703 42 310 034 42 310 034 Autres initiatives provinciales : Bourse Gregory Ferrier Île-du-Prince-Édouard Terre-Neuve-et-Labrador 481 676 Autres initiatives provinciales : Subvention SOUS-TOTAL 12 000 Fonds de recherche de la Fédération 129 3 675 352 3 675 352 Bourses de fonctionnement nationales 167 4 575 377 4 575 377 - 428 571 428 571 999 50 989 334 50 989 334 Réseau canadien contre les accidents cérébrovasculaires * TOTAL † Dans la plupart des cas, les chaires de recherche sont financées par des dotations et en partenariat avec la recherche universitaire et en santé. ‡ Centre d’excellence FMC/Richard Lewar – 6 millions de dollars (1999-2009) * Total 3 millions de dollars (1999-2006) 7 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 3. RESEARCH FUNDING OVERVIEW 3. SURVOL DU FINANCEMENT DE LA RECHERCHE 3.1 3.1 Research Roles Rôles dans la recherche Heart and Stroke Foundation of Canada La Fondation des maladies du cœur du Canada • Manages the peer review for all Grants-in-Aid (GIA). • Gère le processus d’examen par les pairs pour toutes les demandes de subventions. • Manages peer review and award administration for all National Personnel Awards. • Manages peer review and award administration for all aspects of the Federation Research Fund (FRF) strategic initiatives. Provincial Heart and Stroke Foundations • Administer Grants-in-Aid, including funding decisions, award administration, monitoring and evaluation. • Manage all aspects, including peer review, of province-specific research initiatives. An exception is the Heart and Stroke Foundation of Ontario (HSFO) Career Investigator program, reviewed by a standing Heart and Stroke Foundation of Canada (HSFC) subcommittee. 3.2 Scientific Review Process Scientific peer review is the cornerstone of the Foundation’s research enterprise. All research funded by HSF, at a national or provincial level, undergoes peer review and must meet criteria for scientific rigor. The Scientific Review Committee (SRC) is responsible for maintaining a gold standard peer review process for all applications reviewed through HSFC. The SRC advises the Research Policy and Planning Advisory Committee (RPPAC), a HSFC Board standing committee, on matters related to peer review. In 2006-2007, over 125 of Canada’s top cardio- and cerebrovascular scientists participated on the SRC, which is organized around subcommittees, each having specific expertise. Collectively, with the input of external reviewers, the SRC has the ability to expertly review applications focusing on any health research theme, from basic biomedical to population health. For the past several years, HSFC has been innovative in adding lay reviewers to subcommittees reviewing GIA and Senior Personnel Awards applications. The objectives of the lay reviewer role are to enhance the accountability and integrity of the HSF peer review process, provide an additional mechanism for 8 • Gère l’examen par les pairs et l’administration des bourses pour toutes les bourses nationales. • Gère l’examen par les pairs et l’administration des bourses pour tous les aspects des initiatives stratégiques du Fonds de recherche de la Fédération. Les Fondations des maladies du cœur provinciales • Administrent les subventions, y compris les décisions de financement, l’administration, la surveillance et l’évaluation des montants accordés. • Administrent tous les aspects, y compris l’examen par les pairs, des initiatives provinciales de financement de la recherche, à l’exception du Programme de bourse de chercheur de carrière de la Fondation des maladies du cœur de l’Ontario (FMCO), dont l’examen par les pairs est effectué par un sous-comité d’examen permanent de la Fondation des maladies du cœur du Canada. 3.2 Processus d’examen scientifique Le processus d’examen scientifique par les pairs constitue la pierre d’assise de l’entreprise de recherche de la Fondation. Toute la recherche financée par la FMC, sur les plans national et provincial, est soumise à l’examen par les pairs et doit respecter des critères de rigueur scientifique. Le Comité d’examen scientifique est responsable du maintien de la plus haute norme de qualité dans le processus d’examen par les pairs, pour toutes les demandes examinées par la FMCC. Le Comité d’examen scientifique conseille le Comité consultatif sur les politiques et la planification de la recherche (CCPPR), un comité permanent du conseil d’administration, sur les sujets couverts par l’examen par les pairs. En 2006-2007, plus de 125 des meilleurs chercheurs du domaine cardiovasculaire et vasculaire cérébral au Canada ont pris part au Comité d’examen scientifique, organisé en sous-comités ayant chacun une expertise spécifique. Collectivement, avec l’apport des examinateurs externes, le Comité d’examen scientifique possède la capacité d’examiner de façon spécialisée toute demande portant sur chacun des thèmes de la recherche en santé, de la recherche biomédicale fondamentale à la recherche sur la santé des populations. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 evaluating relevance of projects to the HSF mission, and increase awareness of the importance of knowledge transfer and exchange. Au cours des dernières années, la FMCC a innové en ajoutant des examinateurs non spécialisés à ses sous-comités d’examen des demandes de subventions et de bourses de chercheurs de carrière. Les objectifs du rôle d’examinateur non spécialisé consistent à améliorer la responsabilité et l’intégrité du processus d’examen par les pairs de la FMC, à offrir un mécanisme supplémentaire d’évaluation de la pertinence du projet à la mission de la FMC et à mieux sensibiliser à l’importance du partage et de l’application des connaissances. At the provincial level, committee structure varies by province. Research, budgetary allocation, and peer review committees all have roles in funding and review of provincial initiatives. Members of RPPAC, the SRC leadership, and chairs of provincial committees for the year 2006-2007 can be found in Appendix F. 3.3 Research Enterprise Components The HSF research enterprise contains four significant parts presented in Figure 1. The 10 provincial Foundations invest about $50 million annually in the Grant-in-Aid program (research project operating grants); the National Personnel Awards program (salary awards at doctoral, post doctoral fellowship, and new investigator levels); the Federation Research Fund initiatives (strategic research initiatives primarily in partnership with other funding agencies); and provincial research initiatives (personnel awards, program grants, research chair and other programs). Overall funding expenditures for grants and awards have increased from $40 million to over $50 million over the past five years (Figure 2). Figure 1. HSF Research Funding by Program (2006-2007) Grant-in-Aid $31,136,658 Provincial Research Initiatives $11,601,947 Federation Research Fund $3,675,352 National Personnel Awards $4,575,377 Au niveau provincial, la structure des comités varie selon la province. Les comités de recherche, d’allocation budgétaire et d’examen par les pairs ont tous un rôle à jouer dans le financement et l’examen des initiatives provinciales. On retrouve les listes des membres du CCPPR, de la direction des comités d’examen scientifique et des présidents des comités provinciaux pour l’année 2006-2007 à l’Annexe F. 3.3 Éléments de l’entreprise de recherche L’entreprise de recherche de la FMC comporte quatre éléments principaux, qui sont présentés à la Figure 1. Les 10 Fondations provinciales investissent environ cinquante millions de dollars annuellement dans le programme des subventions (subventions de fonctionnement aux projets de recherche); le programme des bourses Numbers represent $ Millions nationales de fonctionnement (bourses de traitement aux niveaux doctoral, postdoctoral et de nouveau chercheur); les initiatives du Federation Research Fonds de recherche de la Fédération (initiatives stratégiques de Fund recherche principalement en partenariat avec d’autres agences de 1.6 2002-2003 financement) et initiatives de recherche provinciales (subventions de 2.3 2003-2004 fonctionnement, subventions de programmes, chaires de recherche 3.1 2004-2005 et autres). Les dépenses totales en subventions et en bourses ont 4.0 2005-2006 augmenté de 40 millions de dollars à 50 millions de dollars au cours 3.7 2006-2007 de cinq dernières années (Figure 2). Personnel Figure 1. Financement de la FMC à laNational recherche, par Awards 2002-2003 4.9 programme (2006-2007) 2003-2004 Subventions 31 136 658 $ 2004-2005 2005-2006 2006-2007 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 fig 1 eng 4.9 5.2 Initiatives de 4.8 recherche provinciales 4.6 11 601 947 $ Fonds de recherche Grant-in-Aid de la Fédération 3 675 352 $ 28.0 29.0 Bourses de fonctionnement nationales 4 575 377 $ 29.8 30.0 31.1 Provincial Research Initiatives† fig 1 fre 2002-2003 5.9 2003-2004 5.8 2004-2005 5.9 2005-2006 6.3 2006-2007 11.6 9 Total 2002-2003 2003-2004 entions 6 658 $ Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Figure 2. HSF Research Funding Trends by Program (2002-2007) Figure 2. Tendances de financement de la FMC à la recherche, par programme (2002-2007) Numbers represent $ Millions Les valeurs indiquées sont en millions de dollars. Federation Research Fund Fonds de recherche de la Fédération 1.6 2002-2003 1,6 2002-2003 2003-2004 2.3 2003-2004 2,3 2004-2005 3.1 2004-2005 3,1 2005-2006 2006-2007 4.0 Initiatives de 3.7 recherche provinciales 11 601 947 $ National Personnel Awards 2002-2003 4.9 Fonds de recherche de la Fédération 4.9 3 675 352 $ 5.2 2003-2004 2004-2005 2005-2006 2006-2007 2006-2007 3,7 2003-2004 Basic Bourses de fonctionnement nationales Biomedical 4,9 78% 4,9 2004-2005 5,2 2005-2006 4,8 2006-2007 4,6 2002-2003 29.0 28,0 2003-2004 29,0 2004-2005 29.8 2005-2006 2004-2005 30.0 29,8 2005-2006 30,0 2006-2007 e 31.1 2006-2007 31,1 fig 3 eng Provincial Research Initiatives† Initiatives de recherche provinciales † 2002-2003 5.9 2003-2004 2002-2003 5.8 5,9 2004-2005 2003-2004 5.9 5,8 2005-2006 2004-2005 6.3 5,9 2005-2006 6,3 2006-2007 11.6 2006-2007 Total 2002-2003 2003-2004 2004-2005 2005-2006 2002-2003 42.0 2003-2004 44.0 2004-2005 45.1 2006-2007 2005-2006 51.0 † Includes Research Chair values for year 2006-2007 only. 3.4 Investments across Health Research Themes fig 2 eng Research supported by HSF spans the four health research themes: basic biomedical, clinical, health services/systems, and population health (defined in Appendix G). Figures 3 and 4 show the relative HSF investments across health research themes. Overall, HSF research has traditionally been 10 11,6 Total 40.4 2006-2007 Hea Syst P H Subvention 28.0 2003-2004 4,0 2002-2003 Bourses 4.8 de fonctionnement 4.6 nationales 4 575 377 $ Grant-in-Aid 2002-2003 2005-2006 Clinical 14% 40,4 42,0 44,0 45,1 51,0 † Comprend la valeur de la Chaire de recherche pour l’année 2006-2007 seulement. 3.4 Investissements dans les quatre thèmes de la recherche en santé fig 2 fre La recherche appuyée par la FMC englobe les quatre thèmes de la recherche en santé : biomédicale fondamentale, clinique, systèmes et services de santé et santé des populations (tels que définis à l’Annexe G). Les Figures 3 et 4 illustrent les investissements relatifs de la FMC dans les quatre thèmes de la recherche en santé. Dans l’ensemble, la recherche Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 concentrated heavily in the basic biomedical sciences (Figure 4). Further inmillions the report, funding by health research theme in each of leurs indiquées sont en de dollars. the federation-wide programs is presented. Currently, we do not ds de recherche la Fédération havede data on provincial initiatives by theme. 6 Figure 3. HSF Research Funding by Health Research Theme (2006-2007) ,3 3,1 4,0 Clinical 14% 3,7 financée par la FMC a traditionnellement été fortement concentrée sur les sciences biomédicales fondamentales (Figure 4). Plus loin dans represent Millions ce rapport, on présente leNumbers financement par $thème de la recherche en santé pour chacun des programmes offerts à l’échelle de la Fédération. Basic Présentement, nous n’avons en Biomedical main aucune donnée par thème pour les initiatives provinciales. 29.2 2004-2005 2005-2006 Figure 3. Financement de la FMC à la recherche, par thème 2006-2007 de recherche (2006-2007) Clinical Health Services/ Systems 4% ses de fonctionnement nationales 4,9 Basic Biomedical 78% 4,9 5,2 Population Health 4% 4,6 Figure 4. HSF Research Funding Trends by Health Research 28,0 Theme (2004-2007) 29,0 29,8 Numbers represent $ Millions 29.3 fig 3 eng 30.5 2006-2007 8 11,6 2005-2006 6.0 2006-2007 5.7 2004-2005 Biomédicale 2005-2006 fondamentale 78 % 2006-2007 1.9 1.6 1.4 2005-2006 1.9 2006-2007 1.6 Clinique 14 % 42,0 Santé de la population 4% 44,0 45,1 51,0 1.4 Biomédicale fondamentale 1.6 2004-2005 2002-2003 6.3 2005-2006 29,2 fig 3 fre 29,3 fig 4 eng 2.3 30,5 2003-2004 2004-2005 2004-2005 6,1 2005-2006 6,0 2006-2007 9.2 5,7 2005-2006 3.1 11.0 4.0 13.3 Services et systèmes de santé 3.7 1,4 2004-2005 2006-2007 2005-2006 1,9 2006-2007 1,6 Population Health 11.9 HSFC de la Chaire de recherche pour 1.0 l’année 2006-2007 seulement. 2004-2005 Partner Santé de la population 2005-2006 1.4 2004-2005 1,0 2006-2007 1.6 2005-2006 1,4 2006-2007 1,6 fig 3 fre fig 4 eng Santé de la population 4% Clinique Services et systèmes de santé 4 % Health Services/Systems 40,4 1.4 Health Services/Systems Population Health 2006-2007 Clinical 6.1 5.7 Les valeurs indiquées sont en millions de dollars. Numbers 1.6 represent $ Millions 29.2 2004-2005 2006-2007 Services et systèmes de santé 4 % 2006-2007 2004-2005 3 6.0 2005-2006 tives de recherche provinciales † 2005-2006 9 2005-2006 Clinique 14 % Figure 4. Tendances du financement de la FMC à la recherche, 2004-2005 par thème de1.0recherche en santé (2004-2007) 30,0 Basic 31,1Biomedical 9 6.1 Biomédicale fondamentale 78 % 2004-2005 4,8 ention 2004-2005 29.3 fig 5 eng fig 4 fre 11 30.5 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 4. 2 006-2007 RESEARCH FUNDING BY PROGRAM 4. F INANCEMENT DE LA RECHERCHE PAR PROGRAMME POUR 2006-2007 This section provides summary information for each of the four main components of the HSF research enterprise: Federation-wide research programs: 1. Federation Research Fund 2. National Personnel Awards 3. Grant-in-Aid 4. Province-specific research initiatives: i. Provincial Personnel Awards ii. Provincial Research Chairs iii. Other Provincial Research Initiatives 4.1 Federation Research Fund The Federation Research Fund (FRF) supports research in areas of strategic priority to HSF, typically through a Request for Applications process, and in partnership with other agencies and organizations. New initiatives appearing in this year’s report include: 1) Cardiovascular Complications of Diabetes. This is an initiative led by the Canadian Institutes of Health Research (CIHR) Institute of Circulatory and Respiratory Health aimed at improving the prevention, treatment, and management of diabetes and gaining a better understanding of the interaction between diabetes and cardiovascular disease (CVD) risk factors. 2) B uilt Environment, Obesity and Health. The goal of this HSF-led initiative is to examine how the urban design of our communities, schools, parks and transportation systems impact health. Funding for development grants for these initiatives appear in this report. Full project funding details will appear in the 2007-2008 Research Report and are presently available at www.hsf.ca/research. 3) Reducing Health Disparities. This initiative supports multi-disciplinary research teams and aims to increase understanding of the health status of vulnerable populations. 4) Focus on Stroke V. This highly successful training initiative to support personnel awards in the stroke area was launched for a sixth time. The 19 new awards funded in 2006-2007 are listed in this report. The majority of the projects listed in Appendix A represent the continuation of previously reported research investments. A total of 29 initiatives (representing 129 individual grants and awards) are detailed in Appendix A. 12 La section qui suit offre un sommaire de l’information concernant chacun des quatre principaux volets de l’entreprise de recherche de la FMC : Programmes offerts dans l’ensemble de la Fédération : 1. Fonds de recherche de la Fédération 2. Bourses de fonctionnement nationales 3. Subventions 4. Initiatives de recherche provinciales : i. Bourses de fonctionnement provinciales ii. Chaires de recherche provinciales iii. Autres initiatives de recherche provinciales 4.1 Fonds de recherche de la Fédération Le Fonds de recherche de la Fédération appuie les recherches dans les domaines de priorité stratégique pour la FMC, habituellement par l’entremise d’un processus d’appel de propositions et en partenariat avec d’autres agences et organismes. Parmi les nouvelles initiatives qui apparaissent dans le rapport de cette année, on retrouve notamment : 1) Complications cardiovasculaires associées au diabète. Cette initiative dirigée par l’Institut de la santé circulatoire et respiratoire des Instituts de recherche en santé du Canada (IRSC) vise à améliorer la prévention, le traitement et la prise en charge du diabète, dans le but de mieux comprendre l’interaction entre le diabète et les facteurs de risque reliés aux maladies cardiovasculaires. 2) Environnement bâti, obésité et santé. L’objectif de cette initiative placée sous la gouverne de la FMC consiste à examiner comment l’aménagement urbain de nos collectivités, les écoles, les parcs et les systèmes de transport affectent la santé. Le financement des subventions de développement accordées à ces initiatives apparaît dans le présent rapport. Les détails complets du financement des projets seront publiés dans le Rapport de recherche 2007-2008 et sont présentement disponibles sur le site www.hsf.ca/research. 3) Réduction des disparités en matière de santé. Cette initiative appuie des équipes de recherche multidisciplinaires et vise à mieux comprendre l’état de santé des populations vulnérables. 4) Opération AVC V. Cette initiative de formation couronnée de succès a versé des bourses de recherche sur les AVC pour une sixième reprise. Les 19 nouvelles bourses financées en 2006-2007 sont indiquées dans le présent rapport. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 The total value of HSF’s investment in these projects for 20062007 is $3.7 million. In addition to HSF’s investment, partner funds have further extended the FRF research investments. As outlined in Figure 5, HSF funding is leveraged by a ratio of more than three to one. The Foundation has partnered with numerous organizations since the FRF began, including all of the CIHR institutes, other health charities (e.g., The Kidney Foundation of Canada, Canadian Diabetes Association) and industry (e.g., AstraZeneca Canada, Pfizer Canada) to maximize research dollars in areas of common interest. La majorité des projets qui apparaissent à l’Annexe A représente la continuité des investissements de recherche déjà annoncés dans les rapports précédents. En tout, 29 initiatives, représentant 129 Figure 5. Federation Research Fund Leveraged Funding (2002-2007) Numbers represent $ Millions 2002-2003 2003-2004 1.6 6.3 9.2dollars. Les valeurs indiquées sont en millions de 2004-2005 2005-2006 2006-2007 2005-2006 Clinique 2006-2007 2004-2005 6,1 2005-2006 6,0 2006-2007 5,7 11.0 29,2 1,4 13.3 30,5 3.7 11.9 HSFC One of the objectives of the FRF is to support interdisciplinary 1,9 2005-2006 research in the areas of health services/systems and population 1,6 2006-2007 health. Figures 6 and 7 show a fairly balanced distribution of funds across health research themes. It is important to note, Santé dethat la population however, the Federation Research Fund represents only of overall HSF research investment. 2004-2005 10% 1,0 fig 5 eng 2005-2006 1,4 2006-2007 1,6 fig 4 fre Basic Les valeurs indiquées sont en millions de dollars. Clinical 27% Biomedical 34% 1,6 2002-2003 6,3 29,3 4.0 Partner Services et systèmes de santé 2004-2005 La valeur totale de l’investissement de la FMC dans ces projets en 2006-2007 est de 3,7 millions de dollars. En plus de l’investissement de la FMC, les fonds avancés par les partenaires ont permis de multiplier l’investissement du Fonds de recherche de la Fédération. Tel que décrit à la Figure 5, le financement de la FMC est bonifié à plus du triple de sa valeur. La Fondation a fait équipe avec de nombreux organismes depuis la création du Fonds de recherche de la Fédération, dont la totalité des instituts de recherche des IRSC, d’autres organismes bénévoles en santé (par exemple, la Fondation du rein du Canada, l’Association canadienne du diabète) et l’industrie (par exemple, AstraZeneca Canada, Pfizer Canada) afin de maximiser le financement de la recherche dans des domaines d’intérêt commun. Figure 5. Financement bonifié du Fonds de recherche de la Fédération (2002-2007) 2.3 Biomédicale fondamentale 3.1 2004-2005 subventions et bourses distinctes, sont décrites en détail à l’Annexe A. 2003-2004 2004-2005 2005-2006 2006-2007 2,3 Health Services/ Systems 19% 9,2 Population Health 3,1 21% 11,0 4,0 13,3 3,7 11,9 FMCC Partenaire(s) fig 6 eng Un des objectifs du Fonds de recherche de la Fédération consiste à appuyer la recherche interdisciplinaire dans les domaines des services et systèmes de santé et de la santé des populations. Les Figures 6 et 7 démontrent une distribution relativement équilibrée des fonds entre les divers thèmes de la recherche en santé. Il est important de souligner cependant que le Fonds de recherche de la Fédération ne représente qu’environ 10 % de l’investissement total de la FMC dans la recherche. fig 5 fre 13 valeurs indiquées sont| Research en millions de dollars. Heart and Les Stroke Foundation Report 2006-2007 2002-2003 Fondation des maladies du cœur | Rapport de recherche 2006-2007 1,6 6,3 Figure 6. Federation Research Fund Funding by Health Research Theme 2,3 (2006-2007) 2003-2004 Numbers represent $ Millions Figure 6. Financement du Fonds de recherche de la Fédération par thème de recherche en santé (2006-2007) Basic Biomedical 9,2 3,1 2004-2005 Basic Biomedical 34% 4,0 2005-2006 2006-2007 11,0 Clinical 27% Biomédicale fondamentale 34 % 13,3 11,9 Health Services/ Systems 19% Partenaire(s) Figure 7. Federation Research Fund Funding Trends by Health Research Theme (2004-2007) Numbers represent $ Millions Population Health 1.0 1.2 1.2 fig 5 fre fig 6 eng Clinical ig 7 eng fig 6 fre 14 Health Services/Systems Services et 0.7 de systèmes santé 19 %1.0 0.7 Clinical 10 % Health Services/ Biomédicale fondamentale Systems 1% 1,0 Population 1,2 Health 3% 1,2 Les valeurs indiquées sont en millions de dollars. 2004-2005 2005-2006 2006-2007 Santé de la 2004-2005 population 2005-2006 21 % 2006-2007 Clinique 27 % 0.9 1.0 1.0 Figure 7. Tendances du financement du Fonds de 2004-2005 0.6 recherche de la Fédération par thème de recherche en 2005-2006 0.8 2006-2007 0.8 santé (2004-2007) Basic Biomedical 2004-2005 2005-2006 2006-2007 Clinical 2004-2005 Santé de la population2005-2006 21 % 2006-2007 FMCC 1.2 1.2 2004-2005 2005-2006 2006-2007 3,7 Population Health 21% 2004-2005 2005-2006 2006-2007 Biomédicale fondamentale 34 % 1.0 2004-2005 2005-2006 2006-2007 0.9 1.0 1.0 Clinique 27 % Health Services/Systems 0.7 1.0 0.7 Population Health 0.6 0.8 0.8 Services et systèmes de santé 19 % 2004-2005 2005-2006 2006-2007 fig 6 fre fig 7 eng Clinique 2004-2005 2005-2006 2006-2007 2004-2005 2005-2006 2006-2007 0,9 1,0 Basic 1,0 Biomedical 87% Services et systèmes de santé 0,7 1,0 0,7 Santé de la population 2004-2005 2005-2006 2006-2007 fig 8 eng fig 7 fre 0,6 0,8 0,8 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 4.2 4.2 National Personnel Awards National Personnel Awards build Canada’s cardio- and cerebrovascular research capacity by providing salary support to investigators at early scientific career stages. The 2006-2007 programs included New Investigator, Research Fellowship, Doctoral Research Award, Nursing Research Fellowship, and Visiting Scientist. National Personnel Awards Programs in 2006-2007 New Investigator — A salary award to support new investigators who wish to establish their own independent research laboratory ($50,000 per year for five years, plus obligatory benefits). Research Fellowship — A training award for applicants who have completed a professional degree, MD or PhD (up to $50,000 per year for two to three years). Doctoral Research Award — A training award for graduate students, enrolled in a PhD program, who are undertaking full-time research training ($21,000 per year for up to three years). Nursing Research Fellowship — A training award for nursing researchers enrolled in an MSc/MA, PhD, or research fellowship program ($25,000 per year for up to three years). Visiting Scientist — A salary/travel award that enables established investigators who visit another institution to develop and share research expertise. In 2006-2007, 167 new and continuing awards were funded. This included 13 awards supported in part by industry. The total investment in National Personnel Awards in 2006-2007 was over $4.5 million (Table 3). A list of award recipients can be found in Appendix B. Bourses de fonctionnement nationales Les bourses de fonctionnement nationales développent la capacité de recherche cardiovasculaire et vasculaire cérébrale au Canada en aidant à défrayer le salaire des chercheurs aux premiers stades de leur carrière scientifique. Les programmes 2006-2007 comprennent notamment les bourses de nouveau chercheur, de perfectionnement en recherche, de recherche doctorale, de recherche sur les soins infirmiers et de chercheur invité. Programmes de bourses de fonctionnement nationales en 2006-2007 Nouveau chercheur — Bourse de traitement destinée à appuyer les jeunes chercheurs qui désirent établir leur propre laboratoire de recherche indépendant (50 000 dollars par année pendant cinq ans, plus avantages obligatoires). Perfectionnement en recherche — Bourse de formation destinée aux candidats ayant obtenu un diplôme professionnel M.D. ou Ph.D. (jusqu’à 50 000 dollars par année pendant deux ou trois ans). Recherche doctorale — Bourse de formation destinée aux étudiants de deuxième et troisième cycle inscrits à un programme de doctorat et qui entreprennent une formation en recherche à temps complet (21 000 dollars par année pendant un maximum de trois ans). Bourse de recherche en soins infirmiers — Bourse de formation destinée aux chercheurs en soins infirmiers inscrits à un programme de M.Sc., M.A., Ph.D. ou de perfectionnement en recherche (25 000 dollars par année pendant jusqu’à trois ans). Chercheur invité — Bourse de traitement et de déplacement qui permet à des chercheurs établis de visiter un autre établissement afin d’y développer et d’y partager leur expertise en recherche. En 2006-2007, 167 bourses, nouvelles et en cours, ont été financées. On y retrouve 13 bourses appuyées par l’industrie. L’investissement total dans les bourses de fonctionnement nationales en 2006-2007 a dépassé les 4,5 millions de dollars (Tableau 3). La liste des récipiendaires se trouve à l’Annexe B. 15 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Table 3. Number of National Personnel Awards and Investment of Funds (2006-2007) Tableau 3. Nombre de bourses de fonctionnement nationales et montants investis (2006-2007) Program Recipients (#) Funds Invested ($) Programme Récipi- Montants investis New Investigator 28 1,394,167 endaires Research Fellowship 61 1,753,333 (#) Doctoral Research Award 71 1,269,677 6 150,000 Nursing Research Fellowship Visiting Scientist TOTAL 1 8,200 167 4,575,377 Table 4 highlights the distribution of National Personnel Awards by health research theme. In 2006-2007, the majority of awards were in the basic biomedical area (86%). This is consistent with previous years (Figures 8 and 9). ($) Nouveau chercheur 28 1 394 167 Bourse de perfectionnement en recherche 61 1 753 333 Bourse de recherche au doctorat 71 1 269 677 Perfectionnement en recherche en soins infirmiers 6 150 000 Chercheur invité 1 8 200 167 4 575 377 TOTAL Le Tableau 4 indique la distribution des bourses de fonctionnement nationales par thème de recherche en santé. En 2006-2007, la majorité de ces bourses est allée au domaine biomédical (86 %). L’accent mis sur la recherche biomédicale est comparable aux années précédentes (Figures 8 et 9). Table 4. HSF National Personnel Awards by Health Research Theme (2006-2007) Type of Award Basic Biomedical Clinical (#) ($) (#) Total (#) ($) 23.6 1,168,667 2.9 144,000 - - 1.6 81,500 28.0 1,394,167 Research Fellowship 53.8 1,586,833 6.0 129,333 0.5 8,833 0.7 28,333 61.0 1,753,333 Doctoral Research Award 66.5 1,194,077 3.9 63,350 - - 0.6 12,250 71.0 1,269,677 - - 4.0 100,000 2.0 50,000 - - 6.0 150,000 1.0 8,200 - - - - - - 1.0 8,200 Visiting Scientist ($) Population Health New Investigator Nursing Research Fellowship (#) Health Services/Systems ($) (#) ($) Obligatory Benefits - 56,000 - 7,000 - - - - - 63,000 Travel Allowance (Average) - 77,418 - 8,422 - 1,694 - 1,280 - 88,813 144.9 4,091,196 16.7 452,105 2.5 60,527 2.9 123,363 167.0 4,727,191 TOTAL Tableau 4. Bourses de fonctionnement nationales de la FMC par thème de recherche en santé (2006-2007) Type de bourse Biomédicale Clinique Services et sys- fondamentale (#) Nouveau chercheur tèmes de santé ($) 23,6 (#) 1 168 667 ($) (#) ($) 2,9 144 000 - - Santé de la Total population (#) ($) (#) 1,6 81 500 28,0 ($) 1 394 167 Perfectionnement en recherche 53,8 1 586 833 6,0 129 333 0,5 8 833 0,7 28 333 61,0 1 753 333 Bourse de recherche au doctorat 66,5 1 194 077 3,9 63 350 - - 0,6 12 250 71,0 1 269 677 - - 4,0 100 000 2,0 50 000 - - 6,0 150 000 1,0 8 200 - - - - - - 1,0 8 200 Perfectionnement en recherche en soins infirmiers Chercheur invité Prestations obligatoires - 56 000 - 7 000 - - - - - 63 000 Frais de déplacement (moyenne) - 77 418 - 8 422 - 1 694 - 1 280 - 88 813 144,9 4 091 196 16,7 452 105 2,5 60 527 2,9 123 363 167,0 4 727 191 TOTAL 16 Les valeurs indiquées sont en millions de dollars. HeartBiomédicale and Strokefondamentale Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 1,0 2004-2005 2005-2006 Figure 2006-2007 Numbers represent $ Millions 1,2 Personnel 1,2 8. National Awards Funding by Health Research Theme (2006-2007) Figure 8. Financement des bourses de fonctionnement Basic Biomedical nationales par thème de recherche en santé (2006-2007) 2002-2003 Clinique 0,9 1,0 1,0 2004-2005 2005-2006 2006-2007 2004-2005 2005-2006 2006-2007 Clinical 10 % Health Services/ Systems 1% Services et systèmes de santé 0,7 1,0 0,7 Santé de la Clinical population 0.7 3% 0.6 0.7 0.6 0.4 Biomédicale fondamentale Services/Systems 87Health % 2002-2003 0 2003-2004 0.1 Figure 9. Tendances du financement des bourses de fonc2004-2005 0.1 tionnement nationales par thème de recherche (2002-2007) 2005-2006 0.1 2006-2007 0.1 Population Health 3% 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Santé de la population 2004-2005 2005-2006 2006-2007 0,6 0,8 0,8 Basic Biomedical 87% Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2002-2007) Les valeurs indiquées sont en millions de dollars. Numbers represent $ Millions Basic Biomedical 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 fig 7 fre 8 fre 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Clinique 10 % Clinical Services et systèmes de 0.7 santé 1 % 0.6 Santé de la 0.7 population 0.6 3% 0.4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Health Services/Systems 0 Biomédicale 0.1 fondamentale 0.1 87 % 0.1 0.1 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 4.1 4.2 4.0 4.2 4.0 Population Health Biomédicale fondamentale 4,1 0.2 Numbers represent $2002-2003 Millions 2003-2004 4,2 0.3 2004-20054,0 0.2 Applications Submitted 2005-2006 4,2 0.2 Applications Funded 2006-2007 4,0 0.1 fig 8 fre 28 Clinique B.C./Yukon 13 0,7 2002-2003 0,6 2003-2004 Alt./N.W.T./Nunavut 0,7 25 2004-2005 0,6 7 2005-2006 fig 8 eng 2006-2007 0,4 Sask. C Alb. / T.N.-O fig 9 eng 5 1 Services et systèmes de santé 2002-2003 0 2003-2004 Man. 0,1 6 2004-2005 0,12 2005-2006 0,1 128 2006-2007 Ont. 0,1 33 Santé de la population 82 Que. 0,2 2002-2003 14 0,3 2003-2004 Population Health 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 4. 4 4.0 4 4.0 2003-2004 Clinique 2004-2005 10 % 2005-2006 Services et systèmes de 2006-2007 santé 1 % 0.2 0.3 0.2 0.2 0.1 0,2 2004-2005 0 2005-2006 N.B.0,2 0,10 2006-2007 N.S. 2 There is a wide variation by province in applications submitted and funded. Very few National Personnel Awards applications are funded in the Atlantic provinces, Manitoba, and Saskatchewan (Figure 10). The overall success rate for the National Personnel Awards competitions in 2006-2007 was approximately 25%. fig 9 eng On retrouve de grandes variations dans le nombre de demandes 0 présentées et financées entre les provinces. Très peu de demandes 0 P.E.I. de bourses de fonctionnement nationales sont financées dans les 0 provinces de l’Atlantique, au Manitoba et en Saskatchewan. (Figure 10). Le taux de succès global lors des concours des bourses Canadiens étudian N.L. 1 de fonctionnement nationales en 2006-2007 était d’environ 25 %. fig 9 fre 0 Canadians studying abroad 23 8 17 fig 10 eng Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Figure 10. Number of National Personnel Awards Applications Submitted and Funded by Province/Territory Numbers represent $ Millions (2006-2007) Les valeurs indiquées sont en millions de dollars. Figure 10. Nombre de demandes de bourses de fonctionnement nationales présentées et financées Les valeurs indiquées sont en millions de dollars. par province/territoire (2006-2007) Biomédicale fondamentale Applications Submitted 2002-2003 Applications Funded 2003-2004 2004-2005 28 B.C./Yukon 2005-2006 13 2006-2007 Numbers represent $ Millions Applications Submitted Nombre de demandes présentées Nombre de demandes financées 2002-2003 260 2003-2004 275 238 282004-2005 C.-B. / Yukon 13 2005-2006 2006-2007 4,1 4,2 4,0 4,2 4,0 25 Clinique 7 0,7 2002-2003 0,6 2003-2004 Sask. 5 0,7 2004-2005 1 0,6 2005-2006 0,4 2006-2007 Man. 6 2 Services et systèmes de santé 2002-2003 0 128 Ont. 2003-2004 0,133 2004-2005 0,1 2005-2006 0,1 82 Que. 2006-2007 140,1 N.B. 2002-2003 2003-2004 2004-2005 N.S. 2005-2006 2006-2007 1 Man. 6 2 Applications Funded 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 86 52 74 53 78 Applications Rated Very Good or Above 128 Ont. 2002-2003 151 33 2003-2004 180 2004-2005 164 82 Qc 228 14 2005-2006 2006-2007 196 Santé de la population 0 0 0,2 0,3 2 0,2 0 0,2 0,1 N.-B. 0 0 N.-É. 2 0 Î.-P.-É. 0 0 N.L. 1 0 T.-N.-L. 1 0 fig 9 fre fig 11 eng 23 8 Heart and Stroke Foundation Prestigious Awards Each year, two outstanding New Investigators are recognized for their scientific excellence through the following prestigious HSF awards. Recipients are awarded a $15,000 research allowance (in addition to the $50,000 New Investigator award stipend). fig 10 eng McDonald Scholarship The McDonald Scholarship Award is named in honour of Ewing McDonald, the Heart and Stroke Foundation of Canada’s Executive Director from 1968 to 1987. This award is given annually to the highest-rated applicant in the New Investigator program. Dr. Angela Devlin, of the University of British Columbia, was the Heart and Stroke Foundation’s 2006-2007 McDonald Scholar. Dr. Devlin’s research is focussed on the effects on a baby’s gene function of a mother’s nutrition during pregnancy and the implications for future heart disease and stroke. 18 5 Sask. P.E.I. 0 0 Canadians studying abroad 4.2.1 25 7 Alb. / T.N.-O. / Nunavut Alt./N.W.T./Nunavut Canadiens étudiant à l’étranger 4.2.1 23 8 Prix prestigieux de la Fondation des maladies du cœur Chaque année, deux nouveaux chercheurs exceptionnels voient récompenser leur excellence scientifique par les prix prestigieux suivants de la FMC. Les récipiendaires reçoivent 15 000 dollars d’allocation de recherche (en plus des 50 000 dollars de la Bourse de nouveau chercheur). fig 10 fre Bourse McDonald La bourse McDonald a été instaurée en l’honneur de Ewing McDonald, directeur général de la Fondation des maladies du cœur du Canada de 1968 à 1987. Cette bourse est remise annuellement au candidat ayant obtenu la plus haute note au concours de nouveau chercheur. Dre Angela Devlin, de l’Université de la Colombie-Britannique, est récipiendaire de la Bourse McDonald pour 2006-2007. Les recherches de Dre Devlin portent sur les effets de la nutrition de la mère au cours Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Henry J.M. Barnett Scholarship The Henry J.M. Barnett Scholarship Award was established to honour Dr. Henry J.M. Barnett’s exceptional contributions to stroke research, education, and patient care in Canada. This award is presented annually to a highly rated New Investigator applicant working in stroke research. Dr. Michael Colicos, of the University of Calgary, was the Heart and Stroke Foundation’s 2006-2007 Barnett Scholar. The focus of Dr. Colicos’s research is synaptic remodelling and the potential applications for recovery from stroke. de la grossesse sur le fonctionnement des gènes du bébé, ainsi que ses implications sur sa santé cardiovasculaire future. 4.3 Bourse Henry J.M. Barnett La Bourse Henry J.M. Barnett a été instaurée en hommage à la contribution exceptionnelle de Dr Henry J.M. Barnett en recherche et en éducation sur les AVC ainsi que sur les soins aux patients d’AVC au Canada. Ce prix est présenté annuellement à un nouveau chercheur ayant obtenu une note élevée et travaillant en recherche sur les AVC. Dr Michael Colicos, de l’Université de Calgary, est récipiendaire de la Bourse Barnett de la Fondation des maladies du cœur pour 2006-2007. Les travaux de Dr Barnett portent sur le remodelage synaptique et ses applications en récupération d’AVC. Grant-in-Aid Grants-in-Aid (peer-reviewed nationally, but funded and administered provincially) are the largest category of research expenditure for the Heart and Stroke Foundation. The Grant-inAid program supports the direct operating costs of conducting research, including laboratory supplies, technicians, and some equipment. Grant amounts vary, but typically range from $14,000 to a maximum of $200,000 per year. In 2006-2007, 493 Grants-in-Aid (new and continuing) were funded, representing an investment of over $31 million (Table 5). A list of grant recipients can be found in Appendix C. Table 5. Number of Grants-in-Aid and Investment of Funds (2006-2007) Province/Territory Subvention Les subventions, qui sont évaluées par les pairs sur le plan national, mais financées et administrées par les provinces, représentent la catégorie la plus importante de dépenses en recherche de la Fondation des maladies du cœur. Le programme de subventions couvre les coûts directs de fonctionnement de la recherche, comme les fournitures de laboratoire, les techniciens et certains équipements. Le montant des subventions varie, mais se situe habituellement entre 14 000 dollars et un maximum de 200 000 dollars par année. En 2006-2007, 493 subventions (nouvelles et en cours) ont été financées, ce qui représente un investissement de plus de 31 millions de dollars (Tableau 5). La liste des récipiendaires se trouve à l’Annexe C. Recipients Funds Invested (#) ($) Tableau 5. Nombre de subventions et fonds investis (2006-2007) British Columbia/Yukon 47 4,107,282 Alberta/Northwest Territories/ Nunavut 63 3,391,659 Saskatchewan 10 581,500 Manitoba 21 840,700 Ontario 247 20,054,167 Quebec 88 1,335,514 7 349,160 New Brunswick 4.3 Province/Territoire 4 107 282 Alberta / Territoires du Nord-Ouest / Nunavut 63 3 391 659 Saskatchewan 10 581 500 Manitoba 21 840 700 247 20 054 167 88 1 335 514 7 349 160 10 476 676 Île-du-Prince-Édouard - - Terre-Neuve-et-Labrador - - 493 31 136 658 10 476,676 - - Québec Newfoundland and Labrador - - Nouveau-Brunswick 493 31,136,658 Grants-in-Aid are heavily concentrated ($25 million or 80% of overall expenditure) in the basic biomedical sciences (Figures 11 and 12). ($) 47 Prince-Edward-Island TOTAL Montants investis (#) Colombie-Britannique / Yukon Ontario Nova Scotia Récipiendaires Nouvelle-Écosse TOTAL Les subventions sont fortement concentrées (soit 25 millions de dollars ou 80 % des sommes investies) dans les sciences biomédicales fondamentales (Figures 11 et 12). 19 2003-2004 275 2004-2005 238 2005-2006 307 2006-2007 300 Report 2006-2007 Heart and Stroke Foundation | Research 2002-2003 86 Figure 52 11. Grants-in-Aid 2003-2004 2004-2005 74 Theme (2006-2007) 2005-2006 53 2006-2007 78 Basic Biomedical Funding by Health Research Demandes évaluées comme très bonnes ou supérieures 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 151 2004-2005 2005-2006 Clinique Services et 2006-2007 14 % systèmes de santé 3 % Clinical 4.8 Santé de la 2002-2003 population 5.2 2003-2004 2% 4.5 2004-2005 4.5 2005-2006 4.3 2006-2007 Biomédicale fondamentale 81 % Health Services/Systems Clinical 14 % Health Services/ Systems 3% 228 196 Basic Biomedical 81% Figure 12. Grants-in-Aid Funding Trends by Health Research Theme (2002-2007) Numbers represent $ Millions 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 fig 12 eng Biomédicale fondamentale 22.7 23.2 24.6 24.0 25.3 Clinical 4.8 2002-2003 5.2 2003-2004 4.5 2004-2005 4.5 2005-2006 Clinique 14 % 4.3Services et 2006-2007 systèmes de santé 3 % Health Services/Systems Santé de la 2002-2003 0 population 2003-2004 0 2% 2004-2005 0.6 2005-2006 0.9 Biomédicale 2006-2007 0.9 fondamentale 81 % Population Health 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 0.6 0.6 0.3 0.6 0.7 Again, as in the National Personnel Awards competitions, the number of applications submitted and funded in the Grant-in-Aid program varies widely across provinces (Figures 13 and 14). The average Grant-in-Aid amount invested in 2006-2007 was approximately $63,158 with Ontario offering the largest maximum grant amount ($165,072). The overall success rate for the Grant-in-Aid competition in 2006-2007 was 52%. fig 13 eng 2002-2003 0 2003-2004 Figure 12. Tendances de financement0des 2004-2005 0.6 thème de recherche en santé (2002-2007) 2005-2006 0.9 2006-2007 0.9 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 fig 12 fre 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Clinique 4,8 5,2 4,5 4,5 4,3 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 0 0 0,6 0,9 0,9 Santé de la population 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 0,6 0,6 0,3 0,6 0,7 Numbers represent $ Million Population Health B.C./Yukon 22,7 2002-2003 0.6 23,2 2003-2004 0.6 2004-2005 0.3 24,6 2005-2006 0.624,0 2006-2007 0.7 25,3 32 34 44 40 40 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alta./N.W.T./Nunavut 49 51 52 48 45 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 14 14 12 8 7 fig 13 eng Services et systèmes de santé 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 14 6 23 10 14 Ont. 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Une fois de plus, comme c’est le cas des concours de bourses de fonctionnement nationales, le nombre de demandes soumises Que. et financées dans le cadre du programme des subventions varie 62 2002-2003 considérablement entre les provinces (Figures 2003-2004 13 et 14). Le montant 62 63 moyen versé en subvention en 2006-2007 était2004-2005 d’environ 63 158 dollars 64 2005-2006 et l’Ontario offrait le montant maximum de subvention le plus élevé, fig 13 fre 22.7 23.2 24 24. 2 subventions par Les valeurs indiquées sont en millions de dollars. Basic Biomedical 20 Figure 11. Financement des subventions par thème de 2002-2003 2003-2004 recherche en santé (2006-2007) Population Health 2% 180 164 g 11 fre e Fondation des maladies du cœur | Rapport de recherche 2006-2007 Numbers represent $ Millions Nombre de demandes financées 2006-2007 51 soit 165 072 dollars. Le taux de succès dans le cadre du concours N.B. 2002-2003 5 2003-2004 3 2004-2005 2 2005-2006 0 2006-2007 4 de subventions en 2006-2007 était de 52 %. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Figure 13. Number of Grant-in-Aid Applications Submitted by Province/Territory (2002-2007) Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2002-2007) esent $ Millions Numbers represent $ Millions Numbers represent $ Millions 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 B.C./Yukon 32 34 44 40 40 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 B.C./Yukon 16 14 15 16 19 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 B.C./Yukon 16 14 15 16 19 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alta./N.W.T./Nunavut 49 51 52 48 45 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alta./N.W.T./Nunavut 29 24 35 23 28 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alta./N.W.T./Nunavut 29 24 35 23 28 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 14 14 12 8 7 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 4 5 6 4 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 4 5 6 4 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 12 4 18 4 8 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 12 4 18 4 8 Nunavut 2 2 3 4 Numbers represent $ Millions 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 14 6 23 10 14 Ont. 2002-2003 181 2003-2004 174 214 2004-2005 207 2005-2006 201 2006-2007 Ont. 181 174 214 207 201 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Que. Que. 62 62 63 64 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 51 N.L. 1 0 2 3 1 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.L. 1 0 2 3 1 105 84 102 104 95 Que. 34 32 29 30 32 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.B. N.S. 9 11 15 9 10 P.E.I. 2002-2003 0 2002-2003 2003-2004 1 2003-2004 2004-2005 1 2004-2005 2005-2006 3 2005-2006 2006-2007 0 2006-2007 34 32 29 30 32 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.B. 2002-2003 5 2003-2004 3 2004-2005 2 2005-2006 0 2006-2007 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Ont. 105 2002-2003 84 2003-2004 1022004-2005 104 2005-2006 95 2006-2007 N.B. 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2 2 1 0 2 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.S. 4 6 9 2 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 P.E.I. 0 0 0 0 0 P.E.I. N.L. 2002-2003 1 0 2002-2003 2003-2004 0 0 2003-2004 2004-2005 1 0 2004-2005 2005-2006 0 0 2005-2006 2006-2007 1 0 2006-2007 2002-2003 2 2003-2004 2 2004-2005 1 2005-2006 0 2006-2007 2 N.S. 4 6 9 2 4 20022003200420052006- 21 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Figure 13. Nombre de demandes de subventions présentées par province/territoire (2002-2007) Les valeurs indiquées sont en millions de dollars. Figure 14. Nombre de demandes de subventions financées par province/territoire (2002-2007) Les valeurs indiquées sont en millions de quées sont en millions de dollars. 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 C.-B. / Yukon 32 34 44 40 40 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 C.-B. / Yukon 16 14 15 16 19 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 C.-B. / Yukon 16 14 15 16 19 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alb. / T.N.-O. / Nunavut 49 51 52 48 45 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alb. / T.N.-O. / Nunavut 29 24 35 23 28 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Alb. / T.N.-O. / Nunavut 29 24 35 23 28 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 14 14 12 8 7 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 4 5 6 4 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Sask. 4 5 6 4 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 12 4 18 4 8 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 12 4 18 4 8 / Nunavut 2 2 3 4 Les valeurs indiquées sont en millions de dollars. 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Man. 14 6 23 10 14 Ont. 2002-2003 181 2003-2004 174 2004-2005 214 2005-2006 207 2006-2007 201 214 207 201 51 22 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 T.-N.-L. 1 0 2 3 1 102 104 95 34 32 29 30 32 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.-B. N.-B. 2002-2003 2 2003-2004 2 2004-2005 1 2005-2006 0 2006-2007 2 N.-É. 9 11 15 9 10 Î.-P.-É.T.-N.-L. 2002-2003 0 2002-2003 1 2003-2004 1 2003-2004 0 2004-2005 1 2004-2005 2 2005-2006 3 2005-2006 3 2006-2007 0 2006-2007 1 34 32 29 30 32 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 105 84 Qc Qc 62 62 63 64 N.-B. 2002-2003 5 2003-2004 3 2004-2005 2 2005-2006 0 2006-2007 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2002-2003 105 2003-2004 84 1022004-2005 2005-2006 104 95 2006-2007 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Qc 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Ont. Ont. 181 174 2002-2003 2 2003-2004 2 2004-2005 1 2005-2006 0 2006-2007 2 N.-É. 4 6 9 2 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 N.-É. 4 6 9 2 4 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 Î.-P.-É. 0 0 0 0 0 Î.-P.-É.T.-N.-L. 2002-2003 0 1 2002-2003 2003-2004 0 0 2003-2004 2004-2005 0 1 2004-2005 2005-2006 0 0 2005-2006 2006-2007 0 1 2006-2007 20022003200420052006- Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 4.4 4.4 Province-specific Research Initiatives Initiatives de recherche provinciales In addition to the Grant-in-Aid program, many of the provincial Foundations administer provincial Personnel Awards, Research Chairs, and other research initiatives. En plus du programme de subventions, plusieurs fondations provinciales administrent leurs propres bourses de fonctionnement, chaires de recherche et autres initiatives de recherche. 4.4.1 4.4.1 Provincial Personnel Awards In 2006-2007, the provincial Foundations funded a total of 168 Personnel Awards, building capacity by supporting cardio- and cerebrovascular researchers throughout their careers, from high school students working in research settings through to established senior scientists (Table 6). Bourses de fonctionnement provinciales En 2006-2007, les Fondations provinciales ont financé en tout 168 bourses de fonctionnement destinées à améliorer la capacité de recherche en appuyant des chercheurs du domaine cardiovasculaire et vasculaire cérébral à toutes les étapes de leur carrière, des élèves du secondaire travaillant en milieu de recherche aux chercheurs de carrière solidement établis (Tableau 6). Table 6. HSF Provincial Personnel Awards Funded (2006-2007) Province/Territory Program British Columbia/Yukon - - - - Alberta/Northwest Territories/Nunavut - - - - Saskatchewan Summer Student Scholarship 3 13,500 13,500 Manitoba B.Sc. Medical Student 4 18,000 Red River College (RRC) Student 4 16,000 Ontario Distinguished Scientist Awards (#) Awards ($) Total ($) 6 135,000 31 2,682,475 Clinician Scientist 8 537,000 Research Fellowship 1 47,500 Career Investigator Nursing Post-Doctoral Research Fellowship 34,000 3 177,000 Masters Studentship 21 378,000 Summer Student Scholarship 79 305,500 4,262,475 Quebec - - - - New Brunswick - - - - Nova Scotia - - - - Prince Edward Island - - - - Newfoundland and Labrador - - - - 160 4,309,975 4,309,975 TOTAL 23 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Tableau 6. Bourses de fonctionnement des FMC provinciales (2006-2007) Province/Territoire Programme Colombie-Britannique / Yukon - Alberta / Territoires du Nord-Ouest / Nunavut - - - Saskatchewan Bourse d’été pour étudiant 3 13 500 13 500 Manitoba Étudiant au baccalauréat en médecine 4 18 000 Étudiant du Collège Red River 4 16 000 Ontario Chercheur émérite 6 135 000 31 2 682 475 Chercheur de carrière Nombre de bourses Montant des bourses ($) - - Chercheur clinicien 8 537 000 Perfectionnement en recherche 1 47 500 Perfectionnement en recherche postdoctorale sur les soins infirmiers 3 177 000 Bourse d’études à la maîtrise 21 378 000 Bourse d’été pour étudiant 79 Total ($) - 34 000 305 500 4 262 475 Québec - - - - Nouveau-Brunswick - - - - Nouvelle-Écosse - - - - Île-du-Prince-Édouard - - - - Terre-Neuve-et-Labrador - TOTAL 24 - - - 160 4 309 975 4 309 975 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 4.4.2 4.4.2 Research Chairs and Professorships Research Chair funding provides salary and infrastructure support to enable a leading researcher to develop a particular research focus at a Canadian university. In 2006-2007 a total of 12 Chairs and Professorships were supported by HSF in the areas of cardiology, stroke, and cardiac nursing. This represents an investment of over $1 million (see Table 7). The recipients of these Chairs and Professorships can be found in Appendix D. Chaires de recherche et postes de professeurs Le financement des chaires de recherche offre un soutien salarial et d’infrastructure permettant à un chercheur émérite de développer des intérêts de recherche particuliers au sein d’une université canadienne. En tout, 12 chaires et postes de professeurs sont financés par la FMC dans les domains de la cardiologie, des AVC et des soins infirmiers cardiovasculaires. Cet investissement représente plus d’un million de dollars (voir le Tableau 7). Les titulaires de ces chaires et postes de professeurs sont mentionnés à l’Annexe D. Table 7. Research Chairs and Professorships (2006-2007)† Province/Territory Program British Columbia/Yukon Chair in Stroke Research Awards (#) 1 Awards ($) 110,000 Total ($) Chair in Cardiovascular Research 1 160,000 Professorship in Stroke Research 1 70,000 Chair in Cardiovascular Research 1 173,462 Professorship in Stroke Research 2 160,000 333,462 Saskatchewan - - - - Manitoba - - - - Ontario Chair in Cardiovascular Research 5 527,629 Chair in Cardiac Nursing Research 1 102,489 630,118 Quebec - - - - New Brunswick - - - - Nova Scotia - - - - Prince Edward Island - - - - Newfoundland and Labrador - - - - 12 1,303,580 1,303,580 Alberta/Northwest Territories/Nunavut TOTAL 340,000 † For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions. Tableau 7. Chaires de recherche et postes de professeurs (2006-2007)† Province/Territoire Programme Nombre de Montant des Colombie-Britannique / Yukon Chaire de recherche sur les AVC 1 110 000 Chaire de recherche cardiovasculaire 1 160 000 Poste de professeur en recherche sur les AVC 1 70 000 Chaire de recherche cardiovasculaire 1 173 462 Poste de professeur en recherche sur les AVC 2 160 000 333 462 bourses Alberta / Territoires du Nord-Ouest / Nunavut Total ($) bourses ($) 340 000 Saskatchewan - - - - Manitoba - - - - Ontario Chaire de recherche cardiovasculaire 5 527 629 Chaire de recherche sur les soins infirmiers cardiovasculaires 1 102 489 630 118 Québec - - - - Nouveau-Brunswick - - - - Nouvelle-Écosse - - - - Île-du-Prince-Édouard - - - - Terre-Neuve-et-Labrador - - - - 12 1 303 580 1 303 580 TOTAL † Dans la plupart des cas, les chaires de recherche sont financées par des dotations et en partenariat avec la recherche universitaire et en santé. 25 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 4.4.3 4.4.3 Other Provincial Initiatives In 2006-2007, the provincial Foundations funded a wide variety of other research initiatives. Table 8 provides details of these initiatives and recipients can be found in Appendix E. Autres initiatives provinciales En 2006-2007, les Fondations provinciales ont financé une vaste gamme d’autres initiatives de recherche. Le Tableau 8 offre des détails sur ces initiatives et la liste des récipiendaires se retrouve à l’Annexe E. Table 8. Other Provincial Research Initiatives (2006-2007) Province/Territory Program Awards (#) Awards ($) British Columbia/Yukon Special Initiative: CardioSHARE - Cardiovascular Health and Research Environment Total ($) 1 60,000 60,000 Alberta/Northwest Territories/Nunavut Young Investigator Travel Award 4 20,000 20,000 Saskatchewan Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source - 100,000 100,000 Manitoba R.E. Beamish Award 1 10,000 10,000 1,240,000 Ontario Quebec New Brunswick Program Grant 6 Health Behaviour Research Initiative (GIA) 1 209,242 Stroke Rehabilitation 4 641,039 Age 45+ with Elevated Systolic Blood Pressure 3 757,315 HSF Centre for Stroke Recovery - 1,646,000 HSF/Richard Lewar Centre of Excellence† - 600,000 Publication cost - 119,225 Awards of Excellence 5,212,821 13 100,000 Training Bursaries 2 40,000 140,000 - - - 5,000 Nova Scotia Gregory Ferrier Award 1 5,000 Prince Edward Island Project Grant 1 10,000 Program Funding 1 2,000 - - - - - 428,571 428,571 38 5,988,392 5,988,392 Newfoundland and Labrador Canadian Stroke Network‡ TOTAL † HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009) ‡ Total $3 million (1999-2006) 26 12,000 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Tableau 8. Autres initiatives de recherche provinciales (2006-2007) Province/Territoire Colombie-Britannique / Yukon Programme Initiative spéciale: CardioSHARE – Environnement de santé et de recherche cardiovasculaire Nombre de Montant des bourses bourses ($) Total ($) 1 60 000 60 000 Alberta / Territoires du Nord-Ouest / Nunavut Bourse de déplacement pour jeune chercheur 4 20 000 20 000 Saskatchewan Faisceau d’imagerie et de traitement biomédical du Centre de rayonnement canadien synchrotron - 100 000 100 000 Manitoba Bourse R.E. Beamish 1 10 000 10 000 Ontario Subvention de programme 6 1 240 000 Initiative de recherche sur les comportements liés à la santé (subvention) 1 209 242 Réadaptation d’AVC 4 641 039 45 ans et plus avec tension artérielle systolique élevée 3 757 315 Centre de réadaptation d’AVC de la FMC - 1 646 000 Centre d’excellence FMC/Richard Lewar† - 600 000 Coûts de publication, etc. Québec Prix d’excellence Bourses de formation - 119 225 13 100 000 2 40 000 5 212 821 140 000 Nouveau-Brunswick - - - - Nouvelle-Écosse Bourse Gregory Ferrier 1 5 000 5 000 Île-du-Prince-Édouard Subvention de projet 1 10 000 Financement de programme 1 2 000 - - - - - 428 571 428 571 38 5 988 392 5 988 392 Terre-Neuve-et-Labrador Réseau canadien contre les accidents cérébrovasculaires‡ TOTAL 12 000 † Centre d’excellence FMC/Richard Lewar – 6 millions de dollars (1999-2009) ‡ Contributions totales – 3 millions de dollars (1999-2006) Description of Other Provincial Research Initiatives Description des autres initiatives de recherche provinciales Heart and Stroke Foundation of British Columbia & Yukon (HSFBCY) Special Initiative: CardioSHARE - Cardiovascular Health and Research Environment — HSFCBY is investing $360,000 over two years (March 1, 2007 to Feb. 28, 2009) to develop a data search, classification, and management system for ischemic heart disease. Fondation des maladies du cœur de la Colombie-Britannique et du Yukon (FMCCBY) Heart and Stroke Foundation of Alberta, NWT & Nunavut (HSFA) Young Investigator Travel Awards — HSFA offers an award to new investigators who choose a Canadian Institutes of Health Research (CIHR) grant instead of an HSFA Grant-in-Aid. The Young Investigator Travel Awards promote collaborative future relationships between leading research labs and the Foundation. Initiative spéciale : CardioSHARE - Environnement de santé et de recherche cardiovasculaire — la FMCCBY investit 360 000 dollars sur deux ans (1er mars 2007 au 28 février 2009) afin de développer un système de recherche, de classification et de gestion des données reliées aux maladies cardiaques ischémiques. Fondation des maladies du cœur de l’Alberta, des T.-N.-O. et du Nunavut (FMCA) Bourses de déplacement pour jeune chercheur — La FMCA offre également une bourse à l’intention de jeunes chercheurs qui choisissent une subvention des Instituts de recherche en santé du Canada (IRSC) au lieu d’une subvention de la FMCA pour le même projet. La Bourse de déplacement pour jeune chercheur favorise la création de liens futurs entre les laboratoires de recherche et la Fondation. 27 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Heart and Stroke Foundation of Saskatchewan (HSFS) Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source — Located at the University of Saskatchewan, the Canadian Light Source is Canada’s national centre for synchrotron research. The BMIT beamline is a powerful new tool for the imaging, study and treatment of disease. This facility is funded through a broad-based partnership of supporters, including HSFS. Fondation des maladies du cœur de la Saskatchewan (FMCS) Heart and Stroke Foundation of Manitoba (HSFM) R.E. Beamish Award — HSFM offers an award of excellence in cardiac research. This award is given to the highest rated HSFM GIA recipient in honour of cardiac researcher Dr. Robert Beamish, one of the primary founders of HSFM more than 50 years ago. Award-winning Dr. Beamish served in numerous medical offices and positions throughout his career. He was, and continues to be, a well-respected researcher and well-known for his impact on cardiology in Manitoba. Faisceau d’imagerie et thérapie biomédicales (BMIT) du Centre canadien de rayonnement synchrotron — Situé à l’Université de la Saskatchewan, le Centre canadien de rayonnement synchrotron est le centre national canadien de recherche en rayonnement synchrotron. Le faisceau BMIT est un nouvel outil puissant d’imagerie, d’étude et de traitement des maladies. Ces installations sont financées par l’entremise d’un vaste partenariat de supporteurs, dont la FMCS. Fondation des maladies du cœur du Manitoba (FMCM) Prix R.E. Beamish — La FMCM offre un prix d’excellence en recherche cardiovasculaire. Ce prix est remis au récipiendaire de subvention de la FMCM ayant obtenu la meilleure note, en hommage au chercheur en cardiologie Dr Robert Beamish, un des principaux fondateurs de la FMCM, voilà plus de 50 ans. Récipiendaire de plusieurs distinctions, Dr Beamish a siégé à de nombreux postes et au sein de nombreuses instances médicales au cours de sa carrière. Il a été et continue d’être un chercheur respecté et renommé pour son impact en cardiologie dans la province du Manitoba. Heart and Stroke Foundation of Ontario (HSFO) Program Grants — These grants provide support for teams of three or more investigators engaging in collaborative multidisciplinary research in the fields of cardio- and cerebrovascular disease in Ontario institutions. Fondation des maladies du cœur de l’Ontario (FMCO) Health Behaviour Research Initiative (GIA) — A special strategic Request for Applications was launched to promote research to find more effective ways of encouraging and supporting populations and individuals in initiation and maintenance of behaviours that improve cardio-cerebrovascular health. Initiative de recherche sur les comportements de santé (subvention) — Un appel spécial de soumissions a été lancé afin de promouvoir la recherche visant à découvrir de nouvelles façons d’encourager et d’appuyer plus efficacement les populations et les individus à adopter et à conserver des comportements qui améliorent la santé Stroke Rehabilitation — This Request for Applications is geared to multi-institute, multi-disciplinary, collaborative applications to support research into stroke rehabilitation. Réadaptation d’AVC — Cet appel de soumissions est destiné aux demandes collaboratives multicentriques et multidisciplinaires, afin Age 45+ with Elevated Systolic Blood Pressure — To better understand this area, HSFO launched a research competition focused on managing elevated systolic blood pressure in individuals aged 45 years and older. Tension artérielle systolique élevée chez les 45 ans et plus — Afin de mieux comprendre ce domaine, la FMCO a lancé un concours de recherche portant sur la prise en charge de la tension artérielle Subventions de programme — Ces subventions offrent un soutien aux équipes de trois chercheurs ou plus qui prennent part à des recherches collaboratives et multidisciplinaires dans les domaines des maladies du cœur et des AVC au sein des établissements ontariens. cardiovasculaire et vasculaire cérébrale. d’appuyer la recherche sur la réadaptation d’AVC. systolique élevée chez les personnes âgées de 45 ans et plus. Publication Costs — HSFO reimburses grant recipients for costs related to publications resulting from work completed during the granting period. Coûts de publication — La FMCO rembourse aux récipiendaires de subventions les coûts reliés aux publications résultant des travaux Heart and Stroke Foundation of Quebec (HSFQ) Awards of Excellence — A number of Awards of Excellence are awarded each year by HSFQ in partnership with individual and corporate donors. These awards enhance the Grants-in-Aid and provide additional financial support to Quebec researchers. The awards range from $5,000 to $20,000. Fondation des maladies du cœur du Québec (FMCQ) 28 effectués durant la période de subvention. Prix d’excellence — Un certain nombre de Prix d’excellence sont décernés chaque année par la FMCQ en partenariat avec des donateurs individuels et corporatifs. Ces prix servent à bonifier les subventions et apportent un soutien financier additionnel aux chercheurs québécois. Ces prix vont de 5 000 dollars à 20 000 dollars. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Training Bursaries — The Training Bursaries are awarded by HSFQ, in partnership with the Fonds de la recherche en santé du Québec and the Réseau en santé cardiovasculaire, to PhD students. Bourses de formation — Les bourses de formation sont décernées par la FMCQ, en partenariat avec le Fonds de recherche en santé du Québec et le Réseau de santé cardiovasculaire, à des étudiants Heart and Stroke Foundation of Nova Scotia (HSFNS) Gregory Ferrier Award — HSFNS offers an award of excellence in research. This award is given to the highest rated HSFNS GIA recipient in honour of Dr. Ferrier, an internationally respected, award-winning scientist known for his groundbreaking and innovative research program related to heart failure mechanisms. The award also honours the spirit of Dr. Ferrier’s mentorship to a new generation of researchers; he went above and beyond to ensure they were able to conduct their research in Nova Scotia. Fondation des maladies du cœur de la Nouvelle-Écosse (FMCNÉ) Heart and Stroke Foundation of Prince Edward Island (HSFPEI) Project Grant — HSFPEI provides funding for a research project related to heart disease and stroke. Program Funding — HSFPEI sponsors a speaker at the Prince Edward Island Health Research Forum. au doctorat. Bourse Gregory Ferrier — La FMCNÉ offre une bourse d’excellence en recherche. Cette bourse est décernée au récipiendaire de subvention ayant obtenu la meilleure note, en hommage au Dr Ferrier, un chercheur émérite respecté dans le monde entier pour ses travaux de pionnier et ses recherches innovatrices sur les mécanismes liés à l’insuffisance cardiaque. Le prix rend hommage à l’esprit de mentorat de Dr Ferrier auprès d’une nouvelle génération de chercheurs; Dr Ferrier s’est surpassé afin de leur permettre de mener des recherches en Nouvelle-Écosse. Fondation des maladies du cœur de l’Île-du-Prince-Édouard (FMCÎPÉ) Subvention de projet — La FMCÎPÉ finance un projet de recherche relié aux maladies du cœur et aux AVC. Financement de programme — La FMCÎPÉ commandite un conférencier dans le cadre du Forum de la recherche en santé de l’Île-du-Prince-Édouard. 29 Heart and Stroke Foundation | Research Report 2006-2007 30 Fondation des maladies du cœur | Rapport de recherche 2006-2007 APPENDIX Annexe A FEDERATION RESEARCH FUND FONDS DE RECHERCHE DE LA FÉDÉRATION Dr. Christian Vaillancourt (University of Ottawa) and Dr. Ian Stiell (Ottawa Health Research Institute) were recipients in 2006-2007 of an award funded through the Federation Research Fund’s Resuscitation Outcomes Consortium 2004 initiative, titled Proposal to create a Canadian collaborative RCC. Dr Christian Vaillancourt (Université d’Ottawa) et Dr Ian Stiell (Institut de recherche en santé d’Ottawa) étaient lauréats en 2006-2007 d’une bourse financée par l’initiative Consortium sur les retombées de la réanimation 2004 du Fonds de recherche de la Fédération, intitulée Proposition pour la création d’un CCR collaboratif canadien. Heart and Stroke Foundation | Research Report 2006-2007 Acronym Acronyme Fondation des maladies du cœur | Rapport de recherche 2006-2007 Full name of organization Nom complet de l’organisme ACB.......................................................Alberta Cancer Board AHFMR.................................................Alberta Heritage Foundation for Medical Research AstraZeneca.........................................AstraZeneca Canada Inc. ASC/SAC..............................................Alzheimer Society of Canada / Société Alzheimer du Canada BCCA....................................................British Columbia Cancer Agency CBS / SCS.............................................Canadian Blood Services / Société canadienne du sang CCMB...................................................Cancer Care Manitoba CCOHTA / OCCETS............................Canadian Coordinating Office for Health Technology Assessment / Office canadien de coordination de l’évaluation des technologies de la santé CCS / SCC............................................Canadian Cardiovascular Society / Société canadienne de cardiologie CDA / ACD...........................................Canadian Diabetes Association / Association canadienne du diabète CIHR / IRSC..........................................Canadian Institutes of Health Research / Instituts de recherche en santé du Canada CIHR - Ethics / IRSC Éthique..............CIHR Ethics Office / Bureau de l’éthique des IRSC CIHR - GHRI / IRSC-IRSM....................CIHR Global Health Research Initiative / Initiative des IRSC sur la recherche en santé mondiale CIHR - HIV/AIDS / IRSC VIH/sida.......CIHR HIV/AIDS Research Initiative / Initiative de recherche des IRSC sur le VIH/sida CIHR-KT / IRSC-AC..............................CIHR - Knowledge Translation Branch / Direction de l’application des connaissances des IRSC CIHR/Rx&D / programme Rx&D des IRCS...............................................CIHR/Rx&D Collaborative Research Program / IRSC et Rx&D - Programme de bourses de recherche CLA / APC............................................Canadian Lung Association / Association pulmonaire du Canada CSN / RCACV.......................................Canadian Stroke Network / Réseau canadien contre les accidents cérébrovasculaires CTCRI / ICRCT.....................................Canadian Tobacco Control Research Initiative / Initiative canadienne de recherche pour la lutte contre le tabagisme FPT Task Group on Genomics and Health / Groupe de travail FPT sur la génétique et la santé......................“Federal, Provincial, Territorial Task Group on Genomics and Health / Groupe de travail fédéral-provincial-territorial sur la génomique et la santé“ HC / SC.................................................Health Canada / Santé Canada HSF / FMC............................................Heart and Stroke Foundation / Fondation des maladies du cœur IA / IV....................................................Institute of Aging / Institut du vieillissement IAPH / ISA.............................................Institute of Aboriginal Peoples’ Health / Institut de la santé des Autochtones ICR / IC.................................................Institute of Cancer Research / Institut du cancer ICRH / ISCR..........................................Institute of Circulatory Respiratory Health / Institut de la santé circulatoire et respiratoire IG / IG...................................................Institute of Genetics / Institut de génétique IGH / ISFH............................................Institute of Gender and Health / Institut de la santé des femmes et des hommes 32 Acronym Acronyme Full name of organization Nom complet de l’organisme IHDCYH / IDSEA..................................Institute of Human Development, Child and Youth Health / Institut du développement et de la santé des enfants et des adolescents IHSPR / ISPS.........................................Institute of Health Services and Policy Research / Institut des services et des politiques de la santé III / IMII..................................................Institute of Infection and Immunity / Institut des maladies infectieuses et immunitaires IMHA / IALA.........................................Institute of Musculoskeletal Health and Arthritis / Institut de l’appareil locomoteur et de l’arthrite INMD / INMD......................................Institute of Nutrition, Metabolism, and Diabetes / Institut de la nutrition, du métabolisme et du diabète INMHA / INSMT..................................Institute of Neurosciences, Mental Health, and Addiction / Institut des neurosciences, de la santé mentale et des toxicomanies IPPH / ISPP...........................................Institute of Population and Public Health / Institut de la santé publique et des populations KFOC / FCR.........................................The Kidney Foundation of Canada / Fondation canadienne du rein QLA / APQ...........................................Quebec Lung Association / Association pulmonaire du Québec MSFHR..................................................Michael Smith Foundation for Health Research NCIC / INCC........................................National Cancer Institute of Canada / Institut national du cancer du Canada NHLBI...................................................National Heart Lung and Blood Institute Pfizer.....................................................Pfizer Canada Inc. SCN / RCS............................................Stem Cell Network / Réseau de cellules souches Tekes.....................................................Finnish Funding Agency for Technology and Innovation *In some cases, the official organization name exists in English only. *Dans certains cas, le nom officiel de l’organisation n’existe qu’en anglais. Explanatory Notes Notes explicatives 1. The year following the initiative title indicates the year in which funding began for the initiative. 1. L’année inscrite à la suite du titre de l’initiative indique l’année à laquelle débute le financement de cette initiative. 2. Not all projects listed received funding directly from HSF. In certain initiatives HSF is recognized as a partner for all projects funded within an overall initiative (HSF funds are directed to one or two projects). 2. Les projets mentionnés dans cette liste n’ont pas tous été financés directement par la FMC. Pour certaines initiatives, la FMC est reconnue comme étant un partenaire de tous les projets financés dans le cadre de cette initiative globale (les fonds de la FMC sont dirigés vers un ou deux projets). 33 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 NEW INITIATIVES INITIATIVES NOUVELLES Cardiovascular Complications of Diabetes 2007 Partners: ICRH, CDA, IAPH, III, INMD, HSF, Pfizer, Tekes, HC Total Initiative Funding: $9,381,233 HSF Total Initiative Funding: $650,000 Complications cardiovasculaires du diabète 2007 Partenaires : ISCR, ACD, ISA, IMII, INMD, FMC, Pfizer, Tekes, SC Financement total de l’initiative : 9 381 233 $ Financement total de l’initiative par la FMC : 650 000 $ Description: The program emphasis is on the production of new knowledge, and the translation of research findings into improvements in the health of populations and health care systems at the interface between diabetes and the cardiovascular research communities. Description : Ce programme met l’accent sur la production de nouvelles connaissances et la conversion des résultats de recherche en améliorations de la santé des populations et des systèmes de soins de santé dans le champ d’intérêt commun aux milieux de recherche sur le diabète et sur les maladies cardiovasculaires. Cardiovascular Complications of Diabetes 2007 High Risk Seed Grants Complications cardiovasculaires du diabète 2007 Subventions de démarrage à risque élevé Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Term 06-07 $ Co-chercheur(s) Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* Total $* (All HSF Partners) FMC (tous les partenaires) Theme Thème Moody, Alan Sunnybrook In vivo detection of early diabetic Health vessel wall disease - a possible Sciences role for the RAGE-AGE-RBCCentre Endothelial (RARE) complex at the micro- and macrovascular levels. Ontario: Burns, Peter N; Silverberg, Jay; Tobe, Sheldon W 20072009 $25,000 $47,246 $75,000 $273,246 II Moreau, Pierre; Mathieu, Patrick Université de Montréal Québec: Poirier, Paul; Pibarot, Philippe; Voisine, Pierre 20072009 $25,000 $54,167 $75,000 $300,000 I Total $* (All Partners) (tous les partenaires) Protein gamma carboxylation in diabetes: protential therapeutic avenue for cardiovascular calcification. Cardiovascular Complications of Diabetes 2007 Team Grants Complications cardiovasculaires du diabète 2007 Subventions d’équipe Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Total 06-07 $ Total $* Durée HSF (All Partners) HSF FMC (tous les FMC partenaires) Petrella, Robert J Innovation to reduce cardiovascular complications of diabetes at the intersection of discovery, prevention and knowledge exchange. Ontario: Holdsworth, David W; Shoemaker, J Kevin ; Stewart, Moira; Harris, Stewart B; Finland: Tikkanen, Heikki 20072012 London Health Sciences Centre *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 34 $33,333 $199,800 $500,000 $2,799,530 Theme Thème I Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Built Environment, Obesity and Health Development Grants 2007 Partners: N/A Total Initiative Funding: $40,896 HSF Total Initiative Funding: $40,896 Environnement bâti, obésité et santé 2007 Partenaires : S/O Financement total de l’initiative : 40 896 $ Financement total de l’initiative par la FMC : 40 896 $ Description: Sixteen development grants (up to $5,000 each) were awarded following the review of the Letter of Intent stage of the Built Environment, Obesity and Health Request for Applications (RFA). The funding was used to enable multidisciplinary and geographically diverse teams to come together to plan their research project and to prepare their full application. Description : Seize bourses de développement (jusqu’à 5 000 dollars chacune) ont été décernées après l’étape de l’étude de la lettre d’intention de la demande de propositions sur l’Environnement bâti, l’obésité et la santé ADD. Ces fonds ont servi à permettre aux équipes multidisciplinaires et réparties géographiquement de se réunir afin de planifier leur projet de recherche et de préparer leur demande complète en vue du concours. Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Grants 2006 Partners: IGH, IPPH, IA, IAPH, ICR, ICRH, IHSPR, IHDCYH, III, INMHA, INMD, CIHR - Ethics, CIHR - KT, CIHR - HIV/AIDS, CIHR - GHRI, HSF Total Initiative Funding: $14,574,019 HSF Total Initiative Funding: $249,755 Réduire les disparités sur le plan de la santé et promouvoir l’équité pour les populations vulnérables - Subvention à l’amélioration de la capacité interdisciplinaire (ACI) 2006 Partenaires : ISFH, ISPP, IV, ISA, IC, ISCR, ISPS, IDSEA, IMII, INSMT, INMD, IRSC Éthique, IRSC-AC, IRSC VIH/sida, IRSC-IRSM, FMC Financement total de l’initiative : 14 574 019 $ Financement total de l’initiative par la FMC : 249 755 $ Description: The purpose of the Interdisciplinary Capacity Enhancement (ICE) grant program is to provide support for new or existing groups conducting multi-disciplinary research on themes that align with this strategic initiative. The grants will enable teams to build capacity and add expertise to their core capacities and develop strategies for knowledge translation. It is expected that this targeted investment will lead to understanding and addressing health disparities, and improving the health status of vulnerable populations. Description : L’objectif du programme de subvention à l’amélioration de la capacité interdisciplinaire (ACI) consiste à offrir du soutien aux équipes nouvelles ou déjà formées, qui mènent des recherches multidisciplinaires sur des thèmes conformes à cette initiative stratégique. Ces subventions permettent aux équipes de développer leur capacité et d’ajouter de l’expertise à leurs compétences de base, afin d’élaborer des stratégies de transfert des connaissances. On s’attend à ce que cet investissement ciblé permette de comprendre et de résoudre les inégalités en matière de santé et d’améliorer l’état de santé des populations vulnérables. Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Grants 2006 Réduire les disparités sur le plan de la santé et promouvoir l’équité pour les populations vulnerable - Subventions aux équipes interdisciplinaires de renforcement des capacités (EIRC) 2006 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Grace, Sherry L; Stewart, Donna E Cardiovascular secondary prevention for vulnerable populations: an interdisciplinary approach to improving access to services and outcomes. Ontario: Alter, David A; Anand, Sonia S; Bunker, Steve; Harvey, Paula J; Holder, Glenn; Kaur, Rimmy; Oh, Paul; Rukholm, Ellen E; Rush, James Walter E; Scholey, Patricia E; Williamson, Karen M 20062011 University Health Network Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique $49,755 III: Health Services/Systems III : Services et systèmes de santé Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $148,387 $249,755 Total $* (All Partners) (tous les partenaires) $704,792 Theme Thème III IV: Population Health IV : Santé de la population 35 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 5 2006 Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D Total Initiative Funding: $1,207,917 HSF Total Initiative Funding: $298,661 Opération AVC 5 2006 Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D des IRSC Financement total de l’initiative : 1 207 917 $ Financement total de l’initiative par la FMC : 298 661 $ Description: This initiative, led by HSF, supports doctoral research awards, postdoctoral fellowships and new investigator awards in the area of stroke. These funds help build greater capacity for stroke research in Canada. Description : Cette initiative menée par la FMC soutient des bourses de recherche au doctorat, des bourses de recherche postdoctorale et des bourses aux nouveaux chercheurs dans le domaine des AVC. Ces fonds contribuent à accroître la capacité de recherche sur les AVC au Canada. Focus on Stroke 5 2006 Postdoctoral Fellowships Opération AVC 5 2006 Bourses de recherche postdoctorale Principal Institute Investigator Institut Chercheur principal Project Projet Ander, Bradley P University of California Protection against delayed daSharp, Frank R mage of intracerebral hemorrhage through inhibition of Src kinase. 20062008 $18,667 $33,334 $50,400 $90,000 I Buck, Brian H Sunnybrook Health Sciences Centre Carotid atheroma treated with aggressive lipid management assessed by magnetic resonance imaging (CALM-MR). Saver, Jeffrey L 20052007 $30,800 $55,000 $33,133 $59,167 I, II Gliddon, St. Boniface Catherine M G.H. Research Centre The role of PARP in a model of cerebral ischemia. Anderson, Christopher M 20062008 $1,520 $45,000 $3,040 $90,000 I Gorbet, Diana J University of Waterloo Sex-related differences in human visuomotor control: implications for stroke recovery. Staines, W Richard 20062008 $8,333 $35,000 $21,429 $90,000 I, II Honoré, JeanClaude Hôpital Sainte-Justine Pro-survival role of the peroxidation products isofurans on cerebral microvascular endothelial cells. Chemtob, Sylvain 20062008 $5,952 $25,000 $21,429 $90,000 I MacIntosh, Bradley J John Radcliffe Hospital Investigating neurovascular Matthews, Paul M coupling in the stroke brain using functional imaging techniques. 20062008 $14,000 $25,000 $50,400 $90,000 I, II, III McKay, Catherine Michelle University of Calgary Endothelial ion channels in a rat model of subarachnoid hemorrhagic stroke. Cole, William C 20072009 $3,571 $15,000 $21,429 $90,000 I Spencer, Sarah J University of Calgary Does a neonatal immune challenge affect emotional processing after adult stroke? Pittman, Quentin J 20062007 $1,520 $45,000 $1,520 $45,000 I Wetzel, Monica K Hospital for Sick Children Elucidating the role of p63 in excitotoxic and ischemiainduced neuronal death. Miller, Freda D 20062008 $1,520 $45,000 $3,040 $90,000 I Ye, Hui Toronto Western Research Institute Rescue synaptic transmission deficit in aged/Alzheimer’s disease. Carlen, Peter L 20062008 $320 $45,000 $640 $90,000 I, II *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 36 Co-Investigator(s) Term Co-chercheur(s) Durée 06-07 $ Total 06-07 $ Total $* HSF (All Partners) HSF FMC (tous les FMC partenaires) Total $* (All Theme Partners) Thème (tous les partenaires) Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 5 2006 Doctoral Research Awards Opération AVC 5 2006 Bourses de recherche au doctorat Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Term 06-07 $ Durée HSF FMC Auriat, Angela M University of Alberta Mechanisms of rehabilitation therapy following stroke. Colbourne, Frederick 20062009 $4,404 Christie, Tara L University Identifying the role and molecular of Calgary mechanism of PlexinD1 in vascular malformation. Childs, Sarah J 20062008 FreitasAndrade, Moises National Role of placental growth factor in Research hypoxia-induced brain angiogenesis. Council of Canada (Ottawa) Stanimivoric, Danica Ge, Yuan University of British Columbia Total $* HSF FMC Total $* (All Partners) (tous les partenaires) $18,500 $15,714 $66,000 I $5,238 $22,000 $10,476 $44,000 I 20062009 $4,821 $20,250 $15,714 $66,000 I Wang, Yu Tian 20062008 $5,238 $22,000 $10,476 $44,000 I, II Green, Theresa L University Minor stroke transitions and marital of Calgary dyad function in the early postdischarge period. King, Kathryn M 20062007 $3,571 $15,000 $3,571 Luykenaar, Kevin D University PKA/PKG regulation of RhoAof Calgary mediated inhibition of the delayed rectifier potassium current in cerebral arteries. Welsh, Donald G 20062008 $5,238 $22,000 $10,476 $44,000 I Pereira, Jennifer A University Validation and implementation of of Toronto individualized benefit: harm profiles for optimal Warfarin prescribing. Holbrook, Anne M 20062007 $5,238 $22,000 $5,238 $22,000 II, IV Qiu, Guosong St. Paul’s Hospital Lipase function in human macrophages. Hill, John S 20062007 $5,238 $22,000 $5,238 $22,000 I Silasi, Gergely University of Alberta Improving stroke outcome through growth-factor induced recruitment of endogenous stem cells. Colbourne, Frederick 20062009 $5,238 $22,000 $15,714 $66,000 I Modulation of AMPA receptor trafficking in the animal model of stroke. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Total 06-07 $ (All Partners) (tous les partenaires) III: Health Services/Systems III : Services et systèmes de santé Theme Thème $15,000 II, III, IV IV: Population Health IV : Santé de la population 37 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 CONTINUING INITIATIVES INITIATIVES EN COURS Programs of Research Programmes de recherche Childhood Obesity Operating Grants 2005 Partners: HSF, INMD, IHDCYH Total Initiative Funding: $2,540,393 HSF Total Initiative Funding: $601,420 Bourses de fonctionnement en obésité chez les enfants 2005 Partenaires : FMC, INMD, IDSEA Financement total de l’initiative : 2 540 393 $ Financement total de l’initiative par la FMC : 601 420 $ Description: The scope of research covered by this request for applications encompasses healthy body weight and obesity in childhood. This includes development, prevention, intervention, and outcomes associated with healthy body weight and obesity in children; spanning pre-conception and gestation through to maturity; across all four of CIHR’s research themes. A total of 52 applications were submitted to the Childhood Obesity program launched in June 2004. Thirteen applications were approved for funding, seven of which were operating grants. Of these seven, HSF supported four. Description : La portée des recherches couvertes par cet appel de demandes couvre le poids santé et l’obésité chez les enfants. On y retrouve le développement, la prévention, l’intervention et les résultats associés au poids santé et à l’obésité chez les enfants de la préconception et de la gestation à la maturité, sur les quatre thèmes de la recherche au sein des IRSC. En tout, 52 demandes ont été soumises au programme d’obésité chez les enfants depuis son lancement en juin 2004. Treize demandes ont été approuvées pour recevoir du financement, dont sept sous forme de fonds de fonctionnement. Parmi ces sept demandes, quatre étaient financées par la FMC. Childhood Obesity Operating Grants 2005 Bourses de fonctionnement en obésité chez les enfants 2005 Principal Investigator Chercheur principal Institute Institut Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC He, Meizi University of Western Ontario Childhood overweight and obesity management: physicians’ views, practices, perceived barriers and needs. Ontario: Clarson, Cheril L; Harris, Stewart B; Piche, Leonard 20062008 $26,808 $48,634 $86,608 $173,218 III Morrison, Katherine M McMaster University Cardiovascular risk factors, glucose metabolism and intramyocellular lipid in children with obesity at baseline and after a pediatric obesity treatment program. Ontario: Atkinson, Stephanie A; Bar-Or, Oded; Tarnopolsky, Mark; Yusuf, Salim 20052008 $99,255 $198,510 $289,965 $579,931 II Naylor, PattiJean University of British Columbia Evaluating the effectiveness of the dissemination of Action Schools! BC: a socio-ecological intervention to increase physical activity and healthy eating in school children British Columbia: McKay, Heather A; Rhodes, Ryan E; Wharf Higgins, Joan; Ontario: Manske, Stephen R 20052008 $66,000 $200,000 $200,000 $600,000 IV Stewart, Jennifer M Carleton University Maternal employment and childhood obesity. Federal: Chowhan, James 20062008 $10,870 $19,670 $24,847 $49,695 IV *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 38 Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Theme Partners) Thème (tous les partenaires) Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Genomic Medicine and Human Development 2005 Partners: HSF, ICRH, IG, IHDCYH HSF Total Initiative Funding: $600,000 Médecine génomique et développement humain 2005 Partenaires : FMC, ISCR, IG, IDSEA Financement total de l’initiative par la FMC : 600 000 $ Description: The purpose of this RFA is to provide operating grants in support of projects that bridge clinical investigation and more basic scientific research to address an important problem in human development. HSF co-funded one project listed below. Description : L’objectif de cet appel de candidatures consiste à offrir des fonds de fonctionnement aux projets qui relient la recherche clinique et la recherche scientifique fondamentale sur le développement humain. La FMC co-finance un des projets énumérés plus bas. Genomic Medicine and Human Development 2005 Médecine génomique et développement humain 2005 Principal Investigator Chercheur principal Institute Project Institut Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Andelfinger, Gregor U; Nemer, Mona; Richter, Andrea M; Rozen, Rima Hôpital SainteJustine Québec: Bigras, JeanLuc; Dube, MariePierre; Khairy, Paul 20052010 Genetic determinants of congenital heart disease. $120,000 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $465,262 $600,000 Total $*(All Theme Partners) Thème (tous les partenaires) $2,382,246 I,II,IV Subventions à la santé et à la démence vasculaires 2005 Partenaires : FMC, SAC, INSMT, IV, programme Rx&D des IRSC, Pfizer Financement total de l’initiative : 1 297 343 $ Financement total de l’initiative par la FMC : 432 448 $ Vascular Health and Dementia Operating Grants 2005 Partners: HSF, ASC, INMHA, IA, CIHR/Rx&D, Pfizer Total Initiative Funding: $1,297,343 HSF Total Initiative Funding: $432,448 Description: The objective of this HSF-led initiative is to support research that explores the interrelationships between vascular health, vascular dementia and Alzheimer disease. Two competitions were launched in this area, in 2004 and again in 2005. Vascular Health and Dementia Operating Grants 2005 Subventions à la santé et à la démence vasculaires 2005 Description : L’objectif de cette initiative conduite par la FMC consiste à soutenir la recherche portant sur les interrelations entre la santé vasculaire, la démence vasculaire et la maladie d’Alzheimer. Deux concours ont été lancés en ce domaine en 2004 et de nouveau en 2005. Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Belleville, Sylvie Institut Universitaire de Gériatrie de Montréal Impact of vascular dementia, vascular MCI and vascular health on cognition. Québec: Gauthier, Serge G; Massoud, Fadi 20052008 $17,669 $111,425 $114,131 $342,393 II Black, Sandra Sunnybrook Health Sciences Centre In vivo characterization of subcortical vascular cognitive impairment using advanced high field MR techniques. Ontario: Graham, Simon J; Lobaugh, Nancy J; Moody, Alan; Sahlas, Demetrios J; Stanisz, Greg J; Stuss, Donald T 20052008 $20,016 $120,000 $119,953 $359,860 I, II >> Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 39 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Darvesh, Sultan Dalhousie University The cholinergic system and vascular risk factors in Alzheimer’s disease and vascular dementia. Nova Scotia: Hopkins, Daivd A; Rockwood, Kenneth J 20052008 $16,782 Yu, Peter H University of Is increased SSAOSaskatchewan: D’Arcy, K Saskatchewan mediated oxidative Carl R; Pahwa, Punam deamination a risk factor for vascular dementia and Alzheimer’s disease? A biosocial investigation. 20052008 $16,272 Vascular Health and Dementia Operating Grants 2004 Partners: HSF, ASC, INMHA, IA, CIHR/Rx&D, Pfizer Total Initiative Funding: $1,262,100 HSF Total Initiative Funding: $420,300 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $100,721 $100,734 $97,630 $97,629 Total $* (All Partners) (tous les partenaires) Theme Thème $302,203 I $292,887 I. IV Subventions à la santé et à la démence vasculaires 2004 Partenaires : FMC, SAC, INSMT, IV, programme Rx&D des IRSC, Pfizer Financement total de l’initiative : 1 262 100 $ Financement total de l’initiative par la FMC : 420 300 $ Vascular Health and Dementia Operating Grants 2004 Subventions à la santé et à la démence vasculaires 2004 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Boulay, Guylain Université de Sherbrooke Intracellular calcium signaling and vascular Québec: Guillemette, Gaetan 20042007 $35,175 $70,275 $93,600 $281,400 I Carlen, Peter Toronto Western Research Institute Alzheimer’s disease, aging and the ischemic synapse. None 20042007 $44,325 $88,650 $115,500 $346,700 I Corbett, Dale R Memorial University of Newfoundland Exercise, aging and cognitive impairment. Manitoba: Peeling, James; Newfoundland: Harley, Carolyn; Moody-Corbett, Frances L 20042007 $45,000 $90,000 $119,900 $360,000 I Zhang, Wandong National Research Council of Canada Neurovascular Unit in Alzheimer’s disease and cerebral amyloid angiopathy. Ontario: Yan Liu, Qing; Stanimirovic, Danica B; Woulfe, John 20052008 $36,225 $72,375 $274,000 I dementia. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 40 $91,300 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Addressing Health Care & Health Policy Challenges of Genetic Medicine 2004 Partners: IG, IHSPR, IPPH, CCOHTA, HSF, FPT Task Group on Genomics and Health Total Initiative Funding: $2,568,037 HSF Total Initiative Funding: $150,000 Relever les défis des soins et des politiques de santé de la médecine génétique 2004 Partenaires : IG, ISPS, ISPP, OCCETS, FMC, Groupe de travail FPT sur la génomique et la santé Financement total de l’initiative : 2 568 037 $ Financement total de l’initiative par la FMC : 150 000 $ Description: The program was designed to provide operating grant funds in support of research projects, the results of which will better equip health care providers, administrators and policy makers to improve the health of populations and strengthen the health care system in Canada in the face of the rapid growth in new technologies and understandings associated with the “genetics era”. Two projects were funded through this initiative; HSF directly supported one project. Description : Ce programme a été conçu afin de fournir des fonds de fonctionnement à des projets de recherche, dont les résultats serviront à mieux équiper les professionnels de la santé, les administrateurs et les décideurs dans le but d’améliorer la santé des populations et de renforcer le système de santé du Canada face à la croissance rapide des nouvelles technologies et des notions d’« ère de la génétique ». Deux projets ont reçu du financement par l’entremise de cette initiative. La FMC finançait directement un de ces projets. Addressing Health Care & Health Policy Challenges of Genetic Medicine 2004 Relever les défis des soins et des politiques de santé de la médecine génétique 2004 Principal Institute Investigator Institut Chercheur principal Rousseau, Francois Project Projet Université Health care and Laval health policy challenges in genetic laboratory services. Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC British Columbia: Friedman, Jan; Québec: Battista, Renaldo; Blancquaert, Ingeborg Rose; Drouin, Régen; Forest, Jean Claude; Foulkes, William; Giguere, Yves; Godard, Beatrice; Labrecque, Michel; Laflamme, Nathalie; Lamarche, MarieChristine; Lamothe, Lise; Landry, Réjean; Legare, France; Marra, Carlo; Reinharz, Daniel 20042007 Total 06-07 $ (All Partners) (tous les partenaires) $50,000 $715,363 Total $* HSF FMC $150,000 Total $* (All Partners) (tous les partenaires) $2,098,210 Theme Thème III Inflammation and Thrombosis 2004 Partners: HSF, ICRH, NHLBI Total Initiative Funding: $761,596 HSF Total Initiative Funding: $260,000 Inflammation et thrombose 2004 Partenaires : FMC, ISCR, NHLBI Financement total de l’initiative : 761 596 $ Financement total de l’initiative par la FMC : 260 000 $ Description: The program provides support for research on the interplay between inflammation and thrombosis, and encourages translational and pre-clinical studies for the development of anticoagulation agents for better management of thrombotic disorders. Description : Ce programme offre du soutien à la recherche sur les interactions entre l’inflammation et la thrombose et encourage les études de translation et précliniques sur le développement d’agents anticoagulants permettant de mieux contrôler les troubles thrombotiques. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 41 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Inflammation and Thrombosis 2004 Inflammation et thrombose 2004 Principal Institute Investigator Institut Chercheur principal Bajzar, Laszlo Project Projet University Carboxypeptidases in of Alberta thrombosis and inflammation. Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC None 20032008 Total 06-07 $ (All Partners) (tous les partenaires) $65,000 Total $* HSF FMC $182,274 $260,000 Total $* (All Partners) (tous les partenaires) $761,596 Theme Thème I Molecular and Cellular Imaging 2004 Partners: HSF, ICRH, NHLBI Total Initiative Funding: $2,145,500 HSF Total Initiative Funding: $260,000 Imagerie moléculaire et cellulaire 2004 Partenaires : FMC, ISCR, NHLBI Financement total de l’initiative : 2 145 500 $ Financement total de l’initiative par la FMC : 260 000 $ Description: Multidisciplinary approaches are needed to address technical challenges associated with imaging the heart, lung, and blood systems, especially at the cellular and molecular level in vivo. The objectives of this initiative are: to develop novel noninvasive cellular and molecular probes to image specific cellular or molecular targets and events in the cardiovascular, pulmonary, and hematopoietic systems in vivo; and to develop novel imaging techniques or adapt current imaging technologies to utilize these probes to image the cardiovascular, pulmonary, and blood systems at the cellular or molecular level. Description : Des approches multidisciplinaires sont nécessaires pour faire face aux défis techniques associés à l’imagerie du cœur, des poumons et du système circulatoire, surtout au niveau cellulaire et moléculaire in vivo. Les objectifs de cette initiative sont les suivants : développer de nouvelles méthodes de sondage non invasives destinées à l’imagerie cellulaire et moléculaire spécifique et l’activité des systèmes cardiovasculaire, pulmonaire et hématopoïétique in vivo, ainsi que développer de nouvelles techniques d’imagerie ou d’adapter des technologies existantes afin de les utiliser dans l’imagerie cardiovasculaire, pulmonaire et circulatoire au niveau cellulaire et moléculaire. Molecular and Cellular Imaging 2004 Imagerie moléculaire et cellulaire 2004 Principal Investigator Chercheur principal Institute Institut Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Cloutier, Guy HôtelDieu de Cellular imaging of blood flow rheological disorders. Québec: Trudel, Marie; USA: Armstrong, Jonathan K; Fisher, Timothy C; Meiselman, Herbert J 20032008 $32,500 $270,465 $130,000 $1,081,860 I MR imaging of myeloperoxidase activity. Ontario: Bowen, Chris; Hegele, Robert A; Huff, Murray W;Pickering, J Geoffrey; Rogers, Kem A; USA: Bogdanov, Alexei A; Jaffer, Farouc Amin; Josephson, Lee; Libby, Peter; Perez, J Manuel 20032008 $32,500 265910 $130,000 $1,063,640 I Montréal Rutt, Brian K (Canadian Lead); Weissleder, Ralph (American Lead) Robarts Research Institute; Harvard Medical School *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 42 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Theme Partners) Thème (tous les partenaires) Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Obesity New Emerging Teams (NET) 2004 Partners: HSF, INMD Total Initiative Funding: $2,999,776 HSF Total Initiative Funding: $1,000,000 Équipes en voie de formation sur l’obésité (EVF) 2004 Partenaires : FMC, INMD Financement total de l’initiative : 2 999 776 $ Financement total de l’initiative par la FMC : 1 000 000 $ Description: The New Emerging Team Grant is intended to promote the formation of new and previously nonexistent research teams or the growth of small existing teams of researchers in the area of obesity/healthy body weight. Description : La subvention aux équipes en voie de formation est destinée à promouvoir la formation de nouvelles équipes de recherche auparavant inexistantes ou la croissance de petites équipes déjà formées de chercheurs dans le domaine de l’obésité et du poids santé. Obesity New Emerging Teams (NET) 2004 Équipes en voie de formation sur l’obésité (EVF) 2004 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term Durée 06-07 $ HSF FMC Katzmarzyk, Peter T Queen’s University Understanding the individual and socioenvironmental health risks of obesity: The Canadian Heart Health Surveys follow-up study. Lambert, Marie Hôpital SainteJustine Familial study on the prevention of cardiovascular disease and type 2 diabetes in children and adolescents. Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Theme Partners) Thème (tous les partenaires) Alberta: Raine, Kim D; Nova Scotia: Joffres, Michel R; MacLean, David R; Ontario: Elliot, Susan; Saskatchewan: Pahwa, Punam; Reeder, Bruce 20042010 $100,000 $300,000 $500,000 $1,500,000 IV Québec: O’Loughlin, Jennifer Lee; Tremblay, Angelo; Gray-Donald, Katherine; Hanley, James A; Levy, Emile EH; Paradis, Gilles; Poirier, Paul 20042010 $100,000 $299,944 $500,000 $1,499,776 II Obesity New Emerging Teams (NET) 2003 Partners: HSF, CIHR Total Initiative Funding: $3,000,000 HSF Total Initiative Funding: $1,000,000 Équipes en voie de formation sur l’obésité (EVF) 2003 Partenaires : FMC, IRSC Financement total de l’initiative : 3 000 000 $ Financement total de l’initiative par la FMC : 1 000 000 $ Description: Through the HSF Research Fund, the Foundation partnered with INMD to support two NET programs – designed to promote the formation of new and previously nonexistent research teams or the growth of small existing teams of researchers in the area of obesity/healthy body weight. Description : Par l’entremise du Fonds de recherche de la Fondation des maladies du cœur, la Fondation s’est associée à l’INMD pour financer deux programmes EVF, destinés à promouvoir la formation de nouvelles équipes de recherche auparavant inexistantes ou la croissance de petites équipes déjà formées de chercheurs dans le domaine de l’obésité et du poids santé. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 43 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Obesity New Emerging Teams (NET) 2003 Équipes en voie de formation sur l’obésité (EVF) 2003 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term Durée 06-07 $ HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Raine, Kim University An ecological of Alberta perspective on the promotion of healthy weights. Alberta: Church, William; McCargar, Linda; Plotnikoff, Ronald C; Wild, T Cameron 20032008 $100,000 $300,000 $500,000 $1,500,000 IV Sharma, Arya Mitra Hamilton General Hospital Ontario: Anand, Sonia S; Austin, Richard C; Weitz, Jeffrey I; Yusuf, Salim 20032008 $100,000 $300,000 $500,000 $1,500,000 I, II Obesity and atherothrombosis. Palliative / End of Life Care 2004 Partners: ACB, BCCA, CCMB, IA, ICR, ICRH, IGH, IHSPR, IHDCYH, INMHA, CIHR-KT, HSF Total Initiative Funding: $12,145,811 HSF Total Initiative Funding: $662,800 Soins palliatifs et de fin de vie 2004 Partenaires : ACB, BCCA, CCMB, IV, IC, ISCR, ISFH, ISPS, IDSEA, INSMT, IRSC-AC, FMC Financement total de l’initiative : 12 145 811 $ Financement total de l’initiative par la FMC : 662 800 $ Description: New Emerging Team grants are intended to support the creation or development of teams comprised of investigators undertaking collaborative, multidisciplinary research. The program is designed to promote the formation of new research teams or the growth of small existing teams of researchers in the area of palliative and end of life care. HSF’s primary focus was on communication between family and health care providers at end of life. One project was funded within this focus area. Nine projects were funded in total ranging from “End of life care and vulnerable populations” to “Transitions in pediatric palliative and end of life care”. Description : Les subventions aux équipes en voie de formation sont destinées à soutenir la création ou le développement d’équipes composées de chercheurs impliqués dans des recherches collaboratives et multidisciplinaires. Le programme est conçu dans le but de promouvoir la formation de nouvelles équipes de recherche ou la croissance de petites équipes de recherche déjà en place dans le domaine des soins palliatifs et de fin de vie. L’objectif premier de la FMC est la communication entre la famille et les professionnels de la santé en fin de vie. Un projet a reçu du financement dans ce domaine. Neuf projets variant de « Soins de fin de vie chez les populations vulnérables » à « Transitions en soins palliatifs et de fin de vie pédiatriques » ont reçu une aide financière. Palliative / End of Life Care 2004 Soins palliatifs et de fin de vie 2004 Principal Institute Investigator Institut Chercheur principal Heyland, Daren K Project Projet Queen’s Understanding and University improving communication and decisionmaking at the end of life. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 44 Co-Investigator(s) Co-chercheur(s) British Columbia: Kuhl, David R; Ontario: Cook, Deborah J; Gafni, Amiram; Giacomini, Mita; Tranmer, Joan E Term Durée 20042010 06-07 $ HSF FMC $150,000 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $263,531 $662,800 Total $* (All Theme Partners) Thème (tous les partenaires) $1,325,641 III Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Regenerative Medicine 2004 Partners: CIHR, INMHA, IG, ICRH, IMHA, HSF, SCN Total Initiative Funding: $12,000,000 HSF Total Project Funding: $500,000 Médecine régénérative 2004 Partenaires : IRSC, INSMT, IG, ISCR, IALA, FMC, SCN Financement total de l’initiative : 12 000 000 $ Financement total du projet par la FMC : 500 000 $ Description: The June 2003 RFA offered support for innovative research projects in the areas of Nanotechnology Development and Nanomedicine, Stem Cells, and Tissue Engineering. This support was provided through innovative Pilot Project Grants, New Emerging Teams (NET) Grants, and Interdisciplinary Capacity Enhancement (ICE) Teams Grants. HSF provided funding to one of eight NET Grants funded under this initiative. Description : L’appel aux candidatures de juin 2003 a offert du soutien aux projets de recherche innovateurs dans les domaines du développement des nanotechnologies et de la nanomédecine, des cellules souches et du génie tissulaire. Ce soutien a été offert par l’entremise des subventions aux projets pilotes, des subventions aux équipes en voie de formation et des subventions d’équipes d’amélioration de la capacité interdisciplinaire, des programmes innovateurs. La FMC a financé un des huit projets ayant reçu une subvention EVF dans le cadre de cette initiative. Regenerative Medicine 2004 Médecine régénérative 2004 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Galipeau, Jacques Cardiovascular and respiratory stem cell plasticity - CARE project. British Columbia: Lansdorp, Peter Michael; Karsan, Aly; Ontario: Liu, Peter P; Stewart, Duncan John 20052010 Jewish General Hospital $100,000 Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) $300,000 $500,000 Total $* (All Partners) (tous les partenaires) $1,500,000 Theme Thème I Resuscitation Outcomes Consortium 2004 Partners: HSF, ICRH, NHLBI Total Initiative Funding: $4,127,712 HSF Total Initiative Funding: $650,000 Consortium sur les résultats de la réanimation 2004 Partenaires : FMC, IRSC, NHLBI Financement total de l’initiative : 4 127 712 $ Financement total de l’initiative par la FMC : 650 000 $ Description: The Program provides support for the establishment of a Resuscitation Outcomes Consortium (ROC) to conduct clinical research in the areas of cardiopulmonary arrest and traumatic injury leading to arrest. The ROC, consisting of ten Regional Clinical Centers (RCCs) and a Data and Coordinating Centre (DCC), will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes. Description : Le programme offre du soutien à la mise sur pied d’un Consortium sur les résultats de la réanimation (CRR) afin de mener des études cliniques dans le domaine de l’arrêt cardiorespiratoire et des blessures traumatiques entraînant cet arrêt. Le Consortium, qui comprend dix Centres cliniques régionaux (CCR) et un Centre de données et de coordination (CDC) offre l’infrastructure nécessaire pour la réalisation d’études collaboratives multiples destinées à aider la conversion rapide des percées scientifiques et cliniques en amélioration des résultats de la réanimation. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 45 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Resuscitation Outcomes Consortium 2004 Consortium sur les résultats de la réanimation 2004 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term Durée 06-07 $ HSF FMC Slutsky, Arthur S St. Michael’s Hospital From bench to bedside to curbside. Stiell, Ian Ottawa Health Research Institute Proposal to create a canadian collaborative RCC. Ontario: Black, Sandra E; Davis, David; Dorian, Paul; Hutchison, James S; Lavery, James; Morrison, Laurie J; Redelmeier, Donald A; Rotstein, Ori D; Sibbald, William 20042009 $65,000 $470,216 $325,000 $2,167,032 III British Columbia: Abu-Laban, Riyad B; Christenson, James M; Levy, Adrian R; Macnab, Andrew J; Russell, James A; Simons, Richard K; Sun, Charles Y; Ontario: Herbert, Paul C; Osmond, Martin H; Vaillancourt, Christian; Wells, George A 20042009 $65,000 $420,146 $325,000 $1,960,680 III Sex, Gender & Cardiovascular Disease Interdisciplinary Capacity Enhancement 2004 Partners: IGH, ICRH, HSF, CLA Total Initiative Funding: $5,905,000 HSF Total Initiative Funding: $1,075,000 Description: This research capacity-building program helps forge multidisciplinary teams around the three strategic research themes (i.e., Gender and sex determinants of atherosclerotic disease risks, including metabolic syndrome, across the lifespan; Gender and sex determinants of acute coronary syndromes; Gender and sex determinants of lung disease including airways diseases and lung cancer) and attracts researchers from relevant disciplines including those who have not been primarily or previously involved in health research. Four teams were funded through this initiative, with two receiving funding from HSF. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 46 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Theme Partners) Thème (tous les partenaires) Amélioration de la capacité de recherche interdisciplinaire sur le sexe social, le sexe biologique et les maladies cardiovasculaires 2004 Partenaires : ISFH, ISCR, FMC, APC Financement total de l’initiative : 5 905 000 $ Financement total de l’initiative par la FMC : 1 075 000 $ Description : Ce programme de développement de la capacité de recherche aide à former des équipes multidisciplinaires autour de trois thèmes de recherche stratégique (p. ex., le sexe et les variables sexuelles des risques de maladies athérosclérotiques tout au long de la vie; le sexe et les variables sexuelles des syndromes coronariens aigus; le sexe et les variables sexuelles des maladies respiratoires comme les maladies des voies respiratoires et le cancer du poumon), et attire des chercheurs de disciplines pertinentes, dont ceux qui n’ont pas été principalement ou auparavant associés à la recherche en santé. Quatre équipes ont été financées par l’entremise de cette initiative, dont deux ont reçu l’appui financier de la FMC. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Sex, Gender & Cardiovascular Disease Interdisciplinary Capacity Enhancement 2004 Amélioration de la capacité de recherche interdisciplinaire sur le sexe social, le sexe biologique et les maladies cardiovasculaires 2004 Awardee Institute Récipiendaire Institut Project Supervisor Projet Directeur Term 06-07 $ Durée HSF FMC Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Partners) (tous les partenaires) Theme Thème Anand, Sonia McMaster Sex and gender University determinants of acute coronary syndromes and the metabolic syndrome: Interdisciplinary Capacity Enhancement (ICE) teams grant program. Ontario: Alter, David A; Arthur, Heather M; Gerstein, Hertzel C; Lonn, Eva M; Mehta, Shamir; Natarajan, Madhu K; Sharma, Arya M; Yusuf, Salim; Germany: Blankenberg, Stefan 20052010 $115,000 $300,000 $537,500 $1,476,251 IV Pilote, Louise McGill University Gender and sex determinants of cardiovascular disease: Alberta: Ghali, William; Norris, Colleen M; British Columbia: Humphries, Karin 20052010 $115,000 $300,000 $537,500 $1,476,247 IV from bench to beyond. H; Nova Scotia: Cox, Jafna L; Kirkland, Susan; Ontario: Tu, Jack V; Québec: Eisenberg, Mark J; Hamet, Pavel; O’Loughlin, Jennifer Lee; Tremblay, Johanne ICRH/HSF New Emerging Teams (NET) 2003 Partners: HSF, ICRHTotal Initiative Funding: $4,795,947 HSF Total Initiative Funding: $2,371,128 Équipes en voie de formation ISCR/FMC (EVF) 2003 Partenaires : FMC, ISCR Financement total de l’initiative : 4 795 947 $ Financement total de l’initiative par la FMC : 2 371 128 $ Description: The purpose of this initiative is to build capacity in new and developing areas of research; to build new research teams; and to give researchers a building block for applying for research funding in future years. Description : Le but de cette initiative est de bâtir la capacité de recherche dans des domaines nouveaux et émergents; de créer de nouvelles équipes de chercheurs et d’offrir aux chercheurs une pierre d’assise sur laquelle asseoir le financement de la recherche au cours des prochaines années. ICRH/HSF New Emerging Teams (NET) 2003 Équipes en voie de formation ISCR/FMC (EVF) 2003 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term Durée 06-07 $ HSF FMC Gutkowska, Jolanta Hôtel Dieu de Montréal Development of cardiac cell replacement / regeneration therapies based on cardiomyogenic action of oxytocin. Smith, Graeme N Queen’s University Pre-eclampsia: fetal and maternal outcomes and innovative therapies. Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Theme Partners) Thème (tous les partenaires) Québec: Blaise, Gilbert A; Jankowski, Marek; Paquin, Joanne; Troncy, Eric TE 20032008 $154,000 $308,000 $770,000 $1,557,000 I, II Ontario: Graham, Charles H; Kisilevsky, Barbara; MacDonald, Susan E; Walker, Mark; Wen, Shi Wu 20032008 $172,354 $344,944 $860,889 $1,739,481 II >> Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 47 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term Durée 06-07 $ HSF FMC Tamblyn, Robyn E-Integration in the management of respiratory and circulatory disease: elucidating the multi-level mechanism that optimize population outcomes. Québec: Dubé, Laurette; Emst, Pierre; Mayo, Nancy E; Pinsonneault, Alain; Verter, Vedat 20032008 $149,957 McGill University Chronic Disease New Emerging Teams (NET) 2002 Partners: HSF, CDA, KFOC, ICRH, INMD Total Initiative Funding: $6,975,441 HSF Total Initiative Funding: $500,000 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $299,956 $740,239 Total $* (All Theme Partners) Thème (tous les partenaires) $1,499,466 II, III Équipes en voie de formation sur les maladies chroniques (EVF) 2002 Partenaires : FMC, ACD, FCR, ISCR, INMD Financement total de l’initiative : 6 975 441 $ Financement total de l’initiative par la FMC : 500 000 $ Description: The objectives of this initiative are to: support the creation of new competitive research teams, which show potential for successfully applying for infrastructure team funding in the future; support multidisciplinary and cross-theme research in identified areas of focus; support the training and establishment of new investigators. HSF and its partners funded projects focused on common and related aspects of kidney disease, cardiovascular disease and diabetes. HSF partnered on all six projects under the Chronic Disease NET initiative with our portion of funds flowing directly to two of the six projects Description : Les objectifs de cette initiative sont de : soutenir la création de nouvelles équipes de recherche compétitives qui affichent un potentiel de réussite pour des demandes de financement des équipe d’infrastructure au cours des prochaines années, de soutenir la recherche multidisciplinaire et transthématique dans des domaines d’intérêt déterminés et d’appuyer la formation et l’établissement de nouveaux chercheurs. La FMCC et ses partenaires ont financé des projets portant sur des aspects communs et connexes des maladies rénales, des maladies cardiovasculaires et du diabète. La FMCC a agi à titre de partenaire dans le cadre des six projets regroupés sous le parapluie des maladies chroniques et sa part de financement est allée directement à deux de ces six projets. Chronic Disease New Emerging Teams (NET) 2002 Équipes en voie de formation sur les maladies chroniques (EVF) 2002 Principal Investigator Chercheur principal Institute Institut Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Anderson, Geoffrey M (CoLead); Rochon, Paula A (Co-Lead) University of Toronto Pharmacological management of chronic disease in older adults. Ontario: Hux, Janet; Laupacis, Andreas; United States: Gurwitz, Jerry H; Stukel, Therese 20022007 $0 Johnson, Jeffrey A University of Alberta Establishment of the allliance for Canadian health outcomes research in diabetes (ACHORD) group. Alberta: Ghali, William; Jacobs, Philip; Majumdar, Sumit; Toth, Ellen L 20032008 $45,833 Lebel, Marcel Hôtel Dieu de Québec Cardiovascular health in chronic renal failure. Québec: Agharazii, Mohsen; Cléroux, Jean; Isenring, Paul; Larivière, Richard; Richard, Darren E 20022007 $0 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 48 Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Partners) (tous les partenaires) Theme Thème $0 $1,230,925 I, II, III $177,553 $250,000 $908,600 II, III, IV $306,021 $250,000 $0 $1,250,000 I, II >> Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Chercheur principal Institute Institut Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Nichol, Graham (Co-Lead), O’Brien Bernie (Co-Lead) Ottawa Heart Institute, McMaster University Cardiovascular outcomes related to economic (core) group. Alberta: Armstrong, Paul W; Donaldson, Cameron; Sheldon, Robert S; Ontario: Wells, George A 20022007 $0 Parfrey, Patrick S Health Sciences Centre, St. John’s Canadian collaborative group for the prevention of illness in chronic kidney disease: the Canadian prevention of renal and cardiovascular end-points trial. British Columbia: Levin, Adeera; Molzahn, Anita E; Singer, Joel; Manitoba: Rigatto, Claudio; Newfoundland: Barrett, Brendan; Ontario: Churchill, David; Gerstein, Hertzel C; 20022007 $45,833 20022007 $0 Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) $214,161 Total $* (All Partners) (tous les partenaires) Theme Thème $0 $1,141,608 II, III, IV $217,920 $250,000 $1,250,000 II, III $305,190 $1,194,308 I, II, IV Goeree, Ron Scholey, James W University of Toronto Gender/genes and glomerular-based diseases research group. Ontario: Beanlands, Heather; Cattran, Daniel; McCay, Elizabeth; Miller, Judith A $0 Gene-Environment Interactions Interdisciplinary Health Research Teams (IHRTs) 2002 Partners: HSF, ICRH Total Initiative Funding: $7,926,761 HSF Total Initiative Funding: $2,000,000 Équipes interdisciplinaires de recherche en santé (ÉIRS) sur les interactions entre les gènes et l’environnement 2002 Partenaires : FMC, ISCR Financement total de l’initiative : 7 926 761 $ Financement total de l’initiative par la FMC : 2 000 000 $ Description: This initiative focuses on the interplay between genetic and environmental factors in the manifestation and progression of circulatory and respiratory diseases and disorders. The purpose of the Interdisciplinary Health Research Teams (IHRT) program is to build collaborations among scientists working in the fields of population health epidemiology, environmental health sciences, cell, molecular biology, biochemistry, physiology, pathology, pharmacology, genomics, molecular diagnostics, and biostatistics to plan innovative research programs that integrate molecular and epidemiologic perspectives. The general purpose of the collaboration is to elucidate critical research questions in circulatory and respiratory diseases that cannot be addressed within the confines of a single discipline. HSF partnered with ICRH on all three projects although HSF funding only went directly to one project. Description : Cette initiative portait sur l’interaction entre les facteurs génétiques et environnementaux dans la manifestation et la progression des maladies et troubles circulatoires et respiratoires. L’objectif du programme des Équipes interdisciplinaires de recherche en santé (EIRS) consiste à établir des liens de collaboration entre les chercheurs des domaines de l’épidémiologie de la santé de la population, des sciences de la santé environnementale, des cellules, de la biologie moléculaire, de la biochimie, de la physiologie, de la pathologie, de la pharmacologie, de la génomique, du diagnostic moléculaire et de la biostatistique afin de planifier des programmes de recherche innovateurs intégrant les points de vue moléculaires et épidémiologiques. L’objectif général de cette collaboration consiste à élucider des questions scientifiques critiques au sujet des maladies circulatoires et respiratoires auxquelles il est impossible de répondre à l’intérieur des confins d’une discipline unique. La FMC est partenaire des ISCR au sein des trois projets de cette initiative, bien qu’une aide financière par la FMC n’ait été accordée qu’à un seul de ces projets. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 49 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Gene-Environment Interactions Interdisciplinary Health Research Teams (IHRTs) 2002 Équipes interdisciplinaires de recherche en santé (ÉIRS) sur les interactions entre les gènes et l’environnement 2002 Principal Institute Investigator Institut Chercheur principal Project Projet Co-Investigator(s) Co-chercheur(s) Term 06-07 $ Durée HSF FMC Hamet, Pavel Université Cardiogene: de a consortium Montréal to explore the nature of geneenvironment interactions in major cardiovascular disorders using human and animal models; should lead to targeted therapeutic and preventive interventions in cardiovascular discorders. Québec: Abrahamowicz, Michal; Deng, Alan Y; FrasureSmith, Nancy; Gaudet, Daniel; Lesperance, Francois; Merlo, Ettore; Nattel, Stanley; Pausova, Zdenka; Shatenstein, Bryna; Siemiatycki, Jack; Skamene, Emil; Tanguay, Jean-Francois; Tremblay, Johanne 20022007 $0 Liu, Peter University of Toronto Developing an integrated Canadian strategy to address heart failure - gene environment interaction of host stress response repertoire. Alberta: ter Keurs, Henk EDJ; British Columbia: McManus, Bruce M; Manitoba: Dhalla, Naranjan S; Dixon, Ian M; Kirhsenbaum, Lorrie A; Singal, Pawan K; Ontario: Arnold, J Malcolm O; Backx, Peter H; McKelvie, Robert S; Nolan, Robert P; Ross, Heather J; Rouleau, Jean-Lucien; Tsui, LapChee; Yeh, Wen-Chen; Québec: Hamet, Pavel; White, Michel; USA: Van Eyk, Jennifer E 20022007 $233,333 Paré, Peter University of British Columbia Inflammatory gene haplotypes and their susceptibility in cardiac, vascular and pulmonary disease. British Columbia: Carlson, Christopher; Chan-Yeung, Moira; Frohlich, Jiri J; Graham, Jinko; Hegele, Richard; Hill, John S; James, A Russell; McManus, Bruce M; Munt, Bradley I; Nelson, Colleen; Sandford, Andrew J; Schellenberg, Robert; Scott, J Tebutt; Thompson, Christopher R; Walley, Keith R; Manitoba: Anthonisen, Nicholas R; Becker, Allan 20022007 $0 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 50 Total 06-07 $ Total $* (All Partners) HSF FMC (tous les partenaires) $396,771 Total $* (All Partners) (tous les partenaires) Theme Thème $0 $2,632,272 I $258,333 $2,000,000 $2,550,000 I, II, IV $398,908 $2,744,489 I, II $0 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Training Programs Programmes de formation Focus on Stroke 4 2005 Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D Total Initiative Funding: $1,130,500 HSF Total Initiative Funding: $309,913 Opération AVC 4 2005 Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D des IRSC Financement total de l’initiative : 1 130 500 $ Financement total de l’initiative par la FMC : 309 913 $ Description: This initiative, led by HSF, supports doctoral research awards, postdoctoral fellowships and new investigator awards in the area of stroke. These funds help build greater capacity for stroke research in Canada. This initiative has been launched by HSF annually since 2002. Description : Cette initiative menée par la FMC soutient des bourses de recherche au doctorat, des bourses de recherche postdoctorale et des bourses aux nouveaux chercheurs dans le domaine des AVC. Ces fonds contribuent à améliorer la capacité de recherche sur les AVC au Canada. Cette initiative est mise de l’avant par la FMC annuellement depuis 2002. Focus on Stroke 4 2005 Postdoctoral Fellowships Opération AVC 4 2005 Bourses de recherche postdoctorale Awardee Institute Récipiendaire Institut Project Supervisor Projet Directeur Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Cheung, Paul, Kimming St. Boniface Establishing the causative G.H. Research roles and mechanisms of Centre atherosclerosis induction by Chlamydia pneumonia. Pierce, Grant N 20052007 $11,892 $45,000 $23,784 $90,000 1 Kauffenstein, Gilles GK Université de Laval Rôle de la NTPDasel et des ucleotides dans le contrôle cardiaque et périphérique de la pression artérielle. Sevigny, Jean 20062008 16 183 $ 45 000 $ 25 514 $ 90 000 $ I,II,IV Ramlawi, Basel Beth Israel Deaconess Medical Center Microarray gene expression profiles after cardiac surgery and their correlation to neurocognitive decline and other clinical outcomes. Sellke, Frank 20042006 $3,303 $12,500 $14,534 $55,000 I,II Sun, HongShuo Toronto Western Research Institute Stroke treatment using virally mediated gene silencing of TRP channels. Tymianski, Michael 20052007 $11,892 $45,000 $23,784 $90,000 I Winship, Ian R University of British Columbia Structural plasticity and electrophysiology in cortical neurons imaged during recovery from stroke. Murphy, Timothy H 20052007 $11,892 $45,000 $23,784 $90,000 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 51 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 4 2005 Doctoral Research Awards Opération AVC 4 2005 Bourses de recherche au doctorat Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Aleyasin, Hossein University of Ottawa The role of DJ-1, in stroke model of neuronal death. Park, David S 20052008 $5,814 $22,000 $17,441 $66,000 I,II Brown, Stephen Thomas McMaster University The differential industion and function of the HIF family of transcription factors in response to hypoxia. Nurse, Colin A 20052008 $5,814 $22,000 $17,441 $66,000 I Buttigiege, Josef A McMaster University Mechanism of oxygen sensing in adrenalmedullary chromaffin cells. Nurse, Colin A 20052008 $5,814 $22,000 $17,441 $66,000 I Clark, Darren L University of Alberta Clinical feasibility of mild prolonged hypothermia – a physiology study. Colbourne, Frederick 20052008 $5,814 $22,000 $17,441 $66,000 I,II,III,IV Hundza, Sandra University of Victoria Effect of arm ycling training on the neural control and function of arm and leg muscles after stroke. Zehr, E Paul 20052008 $5,814 $22,000 $17,441 $66,000 I,II Langdon, Kris D Memorial University of Newfoundland Effect of cognitive and physical activity on the progression of vascular dementia. Corbett, Dale R 20052008 $5,814 $22,000 $17,441 $66,000 I Maxwell, Kimberley A University of Calgary Factors mediating neuronal replacement following brain injury. Dyck, Richard H 20052007 $5,814 $22,000 $11,628 $44,000 I,II Rashidian, Juliet University of Ottawa The role of cyclin dependent kinases in ischemia/excitotoxic neuronal death. Park, David S 20052008 $5,814 $22,000 $17,441 $66,000 I,II Theurer, Julie A University of Western Ontario Oropharyngeal stimulation as a treatment for swallowing impairment following stroke. Martin, Ruth E 20042007 $5,814 $22,000 $14,893 $54,500 I,II Windle, Victoria Memorial University of Newfoundland Role of norepinephrine in recovery of function after focal ischemia in rats. Corbett, Dale R 20052006 $925 $3,500 $5,814 $22,000 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 52 Term Durée 06-07 $ HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 3 2004 Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D Total Initiative Funding: $1,437,711 HSF Total Initiative Funding: $343,552 Opération AVC 3 2004 Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D des IRSC Financement total de l’initiative : 1 437 711 $ Financement total de l’initiative par la FMC : 343 552 $ Focus on Stroke 3 2004 New Investigators Opération AVC 3 2004 Bourses de nouveaux chercheurs Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Kong, Jiming BNIP3-activated atypical apoptosis pathway in ischemic neuronal cell death. N/A 20042009 $14,250 $57,000 $71,250 $285,000 I Investigations of novel strategies to improve cellular and behavioral outcomes after adult and perinatal cerebral ischemia. N/A 20042009 $14,250 $57,000 $71,250 $285,000 I Term Durée 06-07 $ HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) University of Manitoba Todd, Kathryn University of G Alberta Term Durée 06-07 $ HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Focus on Stroke 3 2004 Research Fellowships Opération AVC 3 2004 Bourses de perfectionnement en recherche Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Claydon, Thomas W University of British Columbia Molecular mechanism underlying the ischemia and pH-sensitivity of the neuronal and smooth muscle voltage-gated K+channels, Kv1.4 and Kv1.5. Fedida, David 20042006 $792 $3,333 $20,750 $90,000 I Naska, Sibel Hospital for Sick Children Role of the p53 family in excitotoxicity-induced neuronal apoptosis. Miller, Freda D 20032007 $10,375 $45,000 $35,144 $151,923 I Saposnik, Gustavo London Health Sciences Centre Preserving cognition by improving vascular risk factors control: a randomized controlled trial. Hachinski, Vladimir 20042007 $12,750 $55,000 $38,250 $165,000 II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème IV: Population Health IV : Santé de la population 53 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 3 2004 Doctoral Research Awards Opération AVC 3 2004 Bourses de recherche au doctorat Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Term Durée Choi, Hyun Beom University of British Columbia The role(s) of P2X7 receptor in cerebral ischemia. McLarnon, James G 20032006 $833 $3,500 $11,083 $47,500 I Ford, Matthew Robarts Research Institute Computational fluid dynamics modeling of endovascular aneurysm therapy. Steinman, David A 20042007 $4,292 $18,500 $14,541 $62,500 I Gharbawie, Omar A University of Lethbridge Neural and behavioural correlates Whishaw, of subcortical middle cerebral Ian artery ischemia. 20032006 $2,500 $10,500 $12,750 $54,500 I MacIntosh, Bradley Sunnybrook Combining functional imaging Health Sciences and electromyography to assess Centre lower limb deficits in stroke recovery. 20032006 $1,667 $7,000 $11,917 $51,000 II Veljkovic, Dragoslava McMaster University 20042008 $5,000 $21,000 $14,521 $62,417 I Graham, Simon J Expression and biological Hayward, functions of fibrinolytic proteins in Catherine cultured human megakaryocytes. P M Focus on Stroke 2 2003 Partners: HSF, CSN, CIHR/Rx&D, AstraZeneca Total Initiative Funding: $1,259,017 HSF Total Initiative Funding: $331,824 06-07 $ HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Opération AVC 2 2003 Partenaires : FMC, RCACV, programme Rx&D des IRSC, AstraZeneca Financement total de l’initiative : 1 259 017 $ Financement total de l’initiative par la FMC : 331 824 $ Focus on Stroke 2 2003 New Investigators Opération AVC 2 2003 Bourses de nouveaux chercheurs Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Liu, Fang Protein-protein interactions in the regulation of AMPA receptor mediated neurotoxicity. N/A Centre for Addiction and Mental Health *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 54 Term Durée 20032008 06-07 $ HSF FMC $18,833 Total 06-07 $ (All Partners) (tous les partenaires) $57,000 Total $* HSF FMC $93,167 Total $* (All Theme Partners) Thème (tous les partenaires) $281,000 I Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Focus on Stroke 1 2002 Partners: HSF, CSN, ICRH, CIHR/Rx&D, AstraZeneca Total Initiative Funding: $1,714,855 HSF Total Initiative Funding: $324,855 Opération AVC 1 2002 Partenaires : FMC, RCACV, ISCR, programme Rx&D des IRSC, AstraZeneca Financement total de l’initiative : 1 714 855 $ Financement total de l’initiative par la FMC : 324 855 $ Focus on Stroke 1 2002 New Investigators Opération AVC 1 2002 Bourses de nouveaux chercheurs Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Theme Partners) Thème (tous les partenaires) Whelan, Patrick University of Calgary Sensory control of locomotion in the developing mouse. N/A 20022007 $11,400 $57,000 $57,000 $285,000 I Wilson, Richard University of Calgary Chemoreceptor interactions and neural plasticity in the control of breathing. N/A 20022007 $11,400 $57,000 $57,000 $285,000 I Andres Petrasovits Scholarship 2004 Partners: ICRH, HSF Total Initiative Funding: $213,508 HSF Total Initiative Funding: $106,754 La bourse de recherche Andres Petrasovits 2004 Partenaires : ISCR, FMC Financement total de l’initiative : 213 508 $ Financement total de l’initiative par la FMC : 106 754 $ Description: This special award was developed in memory of Dr. Andres Petrasovits, an eminent leader who devoted nearly three decades of his life to cardiovascular health policy. This partnership will support one fellowship award, valued at $70,000 per year for three years in the area of cardiovascular health policy research as it relates to the prevention and control of cardiovascular disease. Description : Cette bourse spéciale a été instaurée en mémoire de Dr Andres Petrasovits, éminent chef de file ayant consacré trois décennies de sa vie aux politiques de santé cardiovasculaire. Ce partenariat permet de soutenir une bourse de perfectionnement en recherche évaluée à 70 000 dollars par année sur trois ans, dans le domaine de la recherche sur les politiques de santé cardiovasculaire et leur lien avec la prévention et le contrôle des maladies cardiovasculaires. Andres Petrasovits Scholarship 2004 Research Fellowships La bourse de recherche Andres Petrasovits 2004 Bourses de perfectionnement en recherche Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Riley, Barbara A political ecology of primary prevention: the case of cardiovascular disease in Canada. Edwards, Nancy Christine University of Ottawa Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Term Durée 20042007 06-07 $ HSF FMC $35,000 III: Health Services/Systems III : Services et systèmes de santé Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $70,000 $106,754 Total $* (All Theme Partners) Thème (tous les partenaires) $213,508 IV IV: Population Health IV : Santé de la population 55 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Canadian Tobacco Control Research Initiative 2004 Partners: INMHA, ICR, IAPH, ICRH, IGH, IHDCYH, NCIC, CCS, HSF, HC, CLA, L’Association Pulmonaire du Québec, CTCRI Total Initiative Funding: $9,525,000 HSF Total Initiative Funding: $803,450 Initiative canadienne de recherche pour la lutte contre le tabagisme 2004 Partenaires : INSMT, IC, ISA, ISCR, ISFH, IDSEA, INCC, SCC, FMC, SC, APC, APQ, ICRCT Financement total de l’initiative : 9 525 000 $ Financement total de l’initiative par la FMC : 803 450 $ Description: This initiative is focused on developing research capacity in the area of tobacco control and nicotine addiction; addressing gaps in research data; stimulating knowledge translation; fostering national coordination and building international collaboration. Outcomes of this research should inform intervention strategies. Three ICE Grants, two Policy Research Grants, and one Knowledge Synthesis Grant were funded. Only the projects which received funding from HSF are listed below. Description : Cette initiative a pour but de développer la capacité de recherche dans le domaine de la lutte contre le tabagisme et la dépendance à la nicotine; d’aborder les écarts dans les données de la recherche; de favoriser la coordination nationale et de bâtir la collaboration internationale. Les résultats de cette recherche devraient donner corps aux stratégies d’intervention. Trois subventions EIRC, deux subventions de recherche sur les politiques et une subvention de synthèse des connaissances ont été financées. Seuls les projets ayant reçu un financement de la FMC sont mentionnés dans la liste qui suit. Canadian Tobacco Control Research Initiative 2004 Interdisciplinary Capacity Enhancement (ICE) Grant Initiative canadienne de recherche pour la lutte contre le tabagisme 2004 Subventions aux équipes interdisciplinaires de renforcement des capacités (EIRC) Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur O’Loughlin, Jennifer Strengthening the links between research, Ontario: Tyndale, Rachel; Québec: Gauvin, Lise; Paradis, Gilles; Renaud, Lise; Tremblay, Michele; USA: DiFranza, Joseph McGill University practice, and public policy to reduce the burden of tobacco. Term 06-07 $ Durée HSF FMC 20042009 $135,000 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $300,000 $675,000 Total $* (All Partners) (tous les partenaires) $1,500,000 Theme Thème III Target Obesity Personnel Awards 2004 Partners: CDA, ICR, IGH, IHDCYH, IMHA, INMD, HSF Total Initiative Funding: $1,400,000 HSF Total Initiative Funding: $339,149 Bourses Objectif Obésité 2004 Partenaires : ACD, IC, ISFH, IDSEA, IALA, INMD, FMC Financement total de l’initiative : 1 400 000 $ Financement total de l’initiative par la FMC : 339 149 $ Description: The aim of this initiative is to encourage more students, recent graduates and postgraduates, including health professionals (such as physicians, nurses, dietitians, exercise physiologists, and behavioral scientists) to train in the area of obesity research and to support newly established investigators to conduct research in the field of obesity. There is an emphasis on the risks for chronic diseases and strategies to reduce these risks. HSF was the lead organization in this initiative. Description : L’objectif de cette initiative consiste à encourager davantage d’étudiants, de diplômés de premier cycle et d’études supérieures, comme des professionnels de la santé, des médecins, des infirmières, des diététistes, des physiologistes de l’exercice et des chercheurs du comportement à recevoir une formation dans le domaine de la recherche sur l’obésité et de soutenir des chercheurs nouvellement établis à mener des recherches dans le domaine de l’obésité. L’accent est mis sur les risques de maladies chroniques et sur les stratégies destinées à réduire ces risques. La FMC a été l’organisation qui a dirigé cette initiatve. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 56 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Target Obesity Personnel Awards 2004 New Investigators Bourses Objectif Obésité 2004 Bourses de nouveaux chercheurs Awardee Project Supervisor Récipiendaire Institut Institute Projet Directeur Netticadan, Thomas Mechanisms underlying cardiac contractile dysfunction in type II diabetes. N/A St. Boniface G.H. Research Centre Term 06-07 $ Durée HSF FMC 20042009 $48,708 Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC $55,000 $256,124 Total $* (All Theme Partners) Thème (tous les partenaires) $275,000 I Target Obesity Personnel Awards 2004 Research Fellowships Bourses Objectif Obésité 2004 Bourses de perfectionnement en recherche Awardee Institute Project Supervisor Term Directeur Durée 06-07 $ Total 06-07 $ Total $* HSF (All Partners) HSF FMC (tous les FMC partenaires) Total $* (All Theme Partners) Thème (tous les partenaires) Récipiendaire Institut Projet Fry, W Mark Queen’s University Electrophysiological characterisation of orexinergic neurons in the lateral hypothalamus. Ferguson, Alastair 20042007 $0 $45,000 $0 $135,000 I Steinberg, Gregory R St. Vincent’s Institute of Medical Research Intracellular mechanisms contributing to skeletal muscle leptin resistance in obesity. Kemp, Bruce E 20042007 $0 $45,000 $0 $150,000 I Tannenbaum, Montreal Beth M Neurological Institute Alterations of brain circuitry in obesity: The role of reward and motivational state. Dagher, Alain 20052008 $0 $45,000 $0 $135,000 II Yoshioka, Mayumi Identification and cloning of appetite and satiety controlling genes. St-Amand, Jonny 20042007 $0 $45,000 $0 $150,000 I Centre hospitalier de l’Université Laval Target Obesity Personnel Awards 2004 Doctoral Research Awards Bourses Objectif Obésité 2004 Bourses de recherche au doctorat Awardee Institute Project Supervisor Récipiendaire Institut Projet Directeur Term Durée Anderson, Kristal D University of Saskatchewan Target Obesity: Identifying childhood predictors of adulthood obesity. Chad, Karen E 20042007 $0 $22,000 $0 $66,000 I Jia, Xuming University of Saskatchewan Methylglyoxal induced insulin resistance. Wu, Lingyun 20042007 $0 $22,000 $0 $66,000 I Major, Geneviève GM Université de Laval Le syndrome d’apnées obstructives du sommeil et les variations de la dépense énergétique. Tremblay, Angelo 20042007 10 250 $ 22 000 $ 30 750 $ 66 000 $ II Purdham, Daniel University of Western Ontario The role of the cardiac leptin system in myocardial ischemia and reperfusion. Karmazyn, Morris 20042007 $0 $22,000 $0 $66,000 I Tomlinson, Juliana J Ottawa Health The identification of transroptional Research intermediary factor 1 beta in the Institute regulation of steroid induced adipoctye differentiation. Haché, Robert JG 20032006 $10,500 $10,500 $10,500 $54,500 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique 06-07 $ Total 06-07 $ HSF (All Partners) FMC (tous les partenaires) III: Health Services/Systems III : Services et systèmes de santé Total $* Total $* (All HSF Partners) FMC (tous les partenaires) Theme Thème IV: Population Health IV : Santé de la population 57 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Strategic Training Initiative in Health Research (STIHR) 2003 Partners: HSF, ICRH Total Initiative Funding: $12,471,000 HSF Total Initiative Funding: $1,248,788 Initiatives stratégiques de formation en recherche dans le domaine de la santé (ISFRS) 2003 Partenaires : FMC, ISCR Financement total de l’initiative : 12 471 000 $ Financement total de l’initiative par la FMC : 1 248 788 $ Description: The aim of the STIR Initiative is to encourage transdisciplinary, integrative heath research, in part through the training of the next generation of researchers, and to increase the capacity of Canada’s health research enterprise to address important research questions in all areas of health research. HSF supported a total of 11 STIRs over two competitions (2003 and 2002). Description : L’objectif de l’Initiative stratégique pour la formation en recherche dans le domaine de la santé (ISFRS) est de favoriser la recherche en santé transdisciplinaire intégrative, en partie par la formation de la prochaine génération de chercheurs, et d’accroître la capacité de l’entreprise de recherche en santé au Canada à répondre aux questions importantes touchant tous les domaines de la recherche en santé. La FMC a appuyé 11 ISFRS au total au cours de deux concours (2003 et 2002). Strategic Training Initiative in Health Research (STIHR) 2003 Initiatives stratégiques pour la formation en recherche dans le domaine de la santé (ISFRS) 2003 Principal Institute Project Co-Investigator(s) Investigator Institut Projet Co-chercheur(s) Arthur, Heather M McMaster University Training program for the development of cardiovascular nursing research capacity in Canada. Alberta: King, Kathryn M; Tapp, Dianne M; British Columbia: Young, Lynne E; Nova Scotia: McFetridge, Judith Ann; Ontario: Rukholm, Ellen; Tranmer, Joan E; Watt-Watson, Judith H; Québec: Purden, Margaret Ann; RobichaudEkstrand, Sylvie 20032009 $37,198 $299,963 $203,143 $1,800,000 III, II, IV Fliegel, Larry University of Alberta Membrane proteins and cardiovascular disease. Alberta: Casey, Joseph R; Coe, James Y; Glover, JN Mark; James, Michael NG; Kavanagh, Katherine M; Light, Peter E; Michalak, Marek; Robertson, Murray; Young, Howard S 20032009 $37,198 $278,463 $213,143 $1,671,000 I MacGillivray, Ross T University of British Columbia Training program in transfusion science. British Columbia: Brooks, Donald E; Burtnick, Leslie D; Carter, Cedric J; Devine, Dana V; Haynes, Charles A; Karsan, Aly; Lehman, Darrin L; Mauk, Grant; Maurer-Spurej, Elizabeth; McMaster, Robert; McNagny, Kelly M; Orvig, Chris; Overall, Christopher; Podor, Thomas J; Pryzdial, Edward LG; Roberts, Clive R; Scott, Mark; Strynadka, Natalie C J 20032009 $37,198 $299,963 $193,143 $1,800,000 II Chercheur Term 06-07 $ Durée HSF FMC principal Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Partners) (tous les partenaires) Theme Thème >> *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 58 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Institute Project Co-Investigator(s) Investigator Institut Projet Co-chercheur(s) Term 06-07 $ Durée HSF FMC Paré, Peter D University of British Columbia IMPACT: integrated and mentored pulmonary and cardiovascular training. British Columbia: Allard, Michael F;Ayas, Najib; Bai, Tony;Cunningham, Kenneth F; Dorscheid, Delbert R; Fleetham, John A; Frohlich, Jiri J; Fitzgerald, J Mark; Granville, David J; Hayashi, Shizu; Hegele, Richard; Hill, John S; Hogg, James C; Levy, Robert Daniel; Mayo, John; McManus, Bruce M; Muller, Nestor; O, Karmin; Podor, Thomas J; Pritchard, Haydn; Road, Jeremy D; Russell, James A; Ryan, Frank; Sandford, Andrew J; Schellenberg, Robert; Seow, Chun Y; Van Breemen, Casey; van Eeden, Stephan F; Walley, Keith R; Wang, Xiaodong; Yang, Decheng; Manitoba: Anderson, Hope D Intengan; Becker, Allan; Choy, Patrick C; Dhalla, Naranjan S; Dixon, Ian M; Ducas, John; Gounni, Abdelilah Soussi; Guzman, Randolph P; Halayko, Andrew; Hatch, Grant M; Kardami, Elissavet; Lukas, Anton; Mink, Steven N; Netticadan, Thomas; Pierce, Grant N; Singal, Pawan K; Stephens, Newman L; Tappia, Paramjit S; Wigle, Jeffrey T; Yang, Xi; Zahradka, Peter 20032009 $37,198 $299,963 $213,143 $1,800,000 I, II Vance, Dennis E University of Alberta The SCOLAR (stroke, cardiovascular, obesity, lipid, atherosclerosis research) training program. Alberta: Agellon, Luis B; Francis, Gordon A; Lee, Mark W; Lehner, Richard; Majumdar, Sumit; Vance, Jean 20032009 $37,198 $299,963 $213,143 $1,800,000 I,II Wang, Rui Lakehead University Gasotransmitter research and training (GREAT). Alberta: Roth, Sheldon; Ontario: Brien, James F; Nakatsu, Kanji; Québec: Blaise, Gilbert A; Troncy, Eric T E; Saskatchewan: Gopalakrishnan, Venkat; Hurst, Thomas S; Loewen, Michele; McNeill, J Robert; Melo, Luis Gabriel; Reeder, Bruce; Saucier, Deborah; Thornhill, James A; Van uum, Stan H M; Wilson, Thomas W; Wu, Lingyun; Zhang, Wenjun 20032009 $37,198 $299,963 $213,143 $1,800,000 I Chercheur principal Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé Total 06-07 $ Total $* (All Partners) HSF (tous les FMC partenaires) Total $* (All Partners) (tous les partenaires) Theme Thème IV: Population Health IV : Santé de la population 59 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Strategic Training Initiative in Health Research (STIHR) 2002 Partners: HSF, ICRH, AHFMR, IGH, CCMB, ICR, IG, IHSPR, III, INMD, INMHA, IPPH, CIHR-KT, MSFHR Total Initiative Funding: $9,394,360 HSF Total Initiative Funding: $850,000 Initiatives stratégiques de formation en recherche dans le domaine de la santé (ISFRS) 2002 Partenaires : FMC, ISCR, AHFMR, ISFH, CCMB, IC, IG, ISPS, IMII, INMD, INSMT, ISPP, IRSC-AC, MSFHR Financement total de l’initiative : 9 394 360 $ Financement total de l’initiative par la FMC : 850 000 $ Strategic Training Initiative in Health Research (STIHR) 2002 Initiatives stratégiques pour la formation en recherche dans le domaine de la santé (ISFRS) 2002 Principal Institute Investigator Institut Project Co-Investigator(s) Projet Co-chercheur(s) Term Durée Chercheur 06-07 $ HSF FMC principal Total 06-07 $ (All Partners) (tous les partenaires) Total $* HSF FMC Total $* (All Partners) (tous les partenaires) Theme Thème Armstrong, Paul University of Alberta Tomorrow’s Research Cardiovascular Health Professionals (TORCH). Alberta: Allen, Peter S; Anderson, Todd J; Archer, Stephen L; Duff, Henry J; Ghali, William; Giles, Wayne R; Haykowsky, Mark J; Jensen, Louise A; Knudtson, Merril L; Lopaschuk, Gary D; Loutzenhiser, Rodger D; McAlister, Finlay A; Michelakis, Evangelos; Plotnikoff, Ronald C; Raine, Kim; Rebeyka, Ivan M; Schulz, Richard; Sheldon, Robert S; Shuaib, Ashfaq; ter Keurs, Henk EDJ; Tsuyuki, Ross T; Ontario: Hayward, Robert SA; Menon, Ravi S 20012007 $50,000 $268,455 $300,000 $1,559,640 I, II, III, IV Cameron, Roy University of Waterloo Tobacco Research. British Columbia: Best, Allan; Johnson, Joy; Lovato, Chris; Ratner, Pamela A; Ontario: Ashley, Mary Jane; Brown, K Stephen; Campbell, Sharon; Cohen, Joanna; Cook, Richard; Ferrence, Roberta; Fong, Geoffrey; Manske, Stephen R; McDonald, Paul W; Poland, Blake; Selby, Peter; Single, Eric; Skinner, Harvey; Sparks, Robert; Thompson, Mary E; Tyndale, Rachel; Zanna, Mark P 20022007 $0 $273,601 $0 $1,499,870 IV Chung, Stephen University of British Columbia Health research training program in transplantation. British Columbia: Duronio, Vincent; Johnson, Pauline; Landolt, Monica; Levy, Robert Daniel; McMaster, Robert; Qayumi, A Karim; The, Hung-Sia; Warnock, Garth; Yoshida, Eric M 20022007 $0 $275,000 $0 $1,500,000 II Fenster, Aaron The John P. Robarts Research Institute Vascular and cerebrovascular transdisciplinary training program (vcTPP). Ontario: Donner, Allan; Ellis, Christopher G; Ferguson, Stephen S G; Hegele, Robert A; Huff, Murray W; Kamel, Mohamed; Pickering, J Geoffrey; Rutt, Brian K; Salama, Magdy 20022007 $45,833 $242,917 $250,000 $1,325,000 I >> *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 60 Heart and Stroke Foundation | Research Report 2006-2007 Principal Institute Investigator Institut Project Co-Investigator(s) Projet Co-chercheur(s) Fondation des maladies du cœur | Rapport de recherche 2006-2007 Term Durée Chercheur 06-07 $ HSF FMC principal Liu, Peter University Cardiovascular of Toronto research: molecules to populations, heart failure to prevention. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale Manitoba: Dixon, Ian M; Kirshenbaum, Lorrie A; Naranjan, S Dhalla; Ontario: Alter, David; Arnold, J Malcolm O; Backx, Peter H; Benoit, Bruneau; Bradley, T Douglas; Floras, John S; Langille, B Lowell; Nolan, Robert P; Parker, Thomas; Ross, Heather J; Rouleau, JeanLucien; Sole, Michael J; Stewart, A Keith; Stewart, Duncan J; Tsui, Lap-Chee; Tu, Jack V; Van Eyk, Jennifer E; Weisel, Richard D; Wittnich, Carin; Yeh, Wen-Chen; Yusuf, Salim; Québec: Hamet, Pavel II: Clinical II : Clinique 20032008 Total 06-07 $ (All Partners) (tous les partenaires) $50,000 III: Health Services/Systems III : Services et systèmes de santé $285,000 Total $* HSF FMC $300,000 Total $* (All Partners) (tous les partenaires) $1,710,000 Theme Thème I, II, III, IV IV: Population Health IV : Santé de la population 61 APPENDIX Annexe B NATIONAL PERSONNEL AWARDS BY PROGRAM BOURSES DE FONCTIONNEMENT NATIONALES PAR PROGRAMME Dr. John Seubert and Dr. Ken Butcher (University of Alberta) were the 2007/2008 recipients of the Heart and Stroke Foundation McDonald Scholarship Award and Henry J.M. Barnett Scholarship Award, respectively. Dr John Seubert et Dr Ken Butcher (Université de l’Alberta) étaient respectivement lauréats 2007-2008 de la Bourse McDonald et de la Bourse Henry J. M. Barnett de la Fondation des maladies du cœur. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Doctoral Research Awards | Bourses de recherche au doctorat Awardee Supervisor Institute Project Keywords Term 06-07 $ Total $* Theme Récipiendaire Directeur Institut Projet Mots-clés Durée Antunes, Tayze Tatiana Sorisky, Alexander University of Ottawa Thyroid stimulating hormone as a regulator of atherogenic adipokines. Thyroid stimulating hormone, adipose tissue, interleukin-6, adipokines, cardiovascular disease. 20062009 $21,000 $63,000 I, II Ayach, Bilal Liu, Peter P Toronto General Hospital Cytokine signalling pathways regulating bone marrow derived stem-cell therapy post-MI. Myocardial infarction, cytokines, stem cell therapy. 20052007 $21,000 $42,000 I Beyea, Michael M Huff, Murray W Robarts Research Institute Attenuation of foam cell formation via selective activation of gene expression. Atherosclerosis, lipid laden foam cells, cholesterol and lipid homeostasis. 20062008 $17,500 $21,000 I Boucher, Jonathan G Sparks, Daniel L University of HDL regulates triacylglyceride Ottawa Heart metabolism. Institute Hepatic lipase, lipoprotein lipase, atherosclerosis, heart disease, tracylglycerides. 20042007 $10,500 $41,500 I Bourgault, Steve Fournier, Alain Institut national de la recherche scientifique Accidents vasculaires cérébraux, apoptose, neurone, neuropeptide, neuroprotection. 20062009 21 000 $ 63 000 $ I Caron, Annabelle Guillemette, Université de Gaétan Sherbrooke Mécanismes de régulation du Second messagers, récepteurs, récepteur de type 3 de l’inositol signallisation intracellulaire, 1,4,5 trisphosphate (IP3R3). phosphorylation, inositol 1,4,5 trisphosphate recepteur (IP3Rs). 20052008 21 000 $ 63 000 $ I Cayouette, Sylvie Boulay, Guylain Identification des protéines impliquées dans le routage intracellulaire de TRPC6. Signalisation intracellulaire, routage intracellulaire, canaux calciques, Rab, TRPC6. 20062009 17 500 $ 42 000 $ I Chan, Anita YM Dyck, Jason University of RB Alberta The effects of PRKAG2 mutations on cardiac energy metabolism. AMPK, PRKAG2, hypertrophy, metabolism, glycogen. 20062009 $21,000 $63,000 I Cho, Taesup Wang, Yu Tian University of British Columbia Functional characterization of synaptic plasticity and synapse formation in the neural stem cells during stroke. Stem cell, PSD-95, neuroligin, synaptic plasticity, stroke. 20052008 $21,000 $63,000 I Clément, Martin Escher, Emmanuel Université de Sherbrooke Détermination de la pochette de liaison du récepteur AT1 par MPA (methionine proximity assay). Recepteurs couples aux proteines G, angiotensine II, pochette de liaison, structure mecanismes d’activation. 20062009 21 000 $ 63 000 $ I Cruz, Rani P McManus, Bruce M St. Paul’s Hospital Elucidating the role of cytochrome p450 enzymes in mitral valve disease. Mitral valve disease, cytochrome p450, myofibroblasts, apoptosis. 20042007 $21,000 $62,000 I Dastani, Zari Genest, Jr, Jacques McGill University Genetics of high density lipoprotein-cholesterol. Genetics, gene identification, cholesterol, high density lipoprotein, cardiovascular risk factor. 20062009 $21,000 $63,000 I, II, IV Université de Sherbrooke Développement et caractérisation pharmacologique d’agonistes à haute stabilité métabolique du neuropeptide PACAP. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 64 Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée David, Laurence S Snutch, Terrance P University of British Columbia Cardiac 1H T-type calcium channels and hypertension. Hypertension, T-type clacium channel, smooth muscle contraction, ion channel modulation, site-directed mutagenesis. 20062008 $21,000 $42,000 I Dent, Melissa R Dhalla, Naranjan S University of Manitoba Gender differences in the mechanisms involved in the development of cardiac remodelling. 20062010 $21,000 $63,000 I Duan, Qingling Rouleau, Guy A Centre hospitalier de l’Université de Montréal Genetic investigation of angioedema associated with angiotensin I-converting enzyme inhibitors. 20062009 $17,500 $42,000 I, II, IV Dungey, Alison A Stewart, Duncan J St. Michael’s Hospital Kruppel-like factor 2: a novel treatment strategy for pulmonary arterial hypertension? 20062009 $21,000 $63,000 I, II Duval, Martine Gratton, JeanPhilippe Institut de recherches cliniques de Montréal Mouvements cellulaires du récepteur VEGFR-2 du VEGF dans les cellules endothéliales. VEGF, récepteur, oxyde nitrique (NO), signalisation intracellulaire, cellules. 20042007 21 000 $ 62 000 $ I Fang, Xiangping Sweeney, Gary York University Regulation of glucose and fatty acid metabolism in cardiomyocytes by adiponectin. Adiponectin, obesity, heart failure, carbohydrate and lipid metabolism. 20062008 $21,000 $42,000 I Flynn, Robyn Zamponi, Gerald W University of Calgary Neurexin and neuroligin modulate neuronal reorganization through interactions with specific receptors. Neuroligin, neurexin, neuronal reorganization, calcium channels, NMDA receptor. 20052008 $21,000 $63,000 I Foster, Glen E Poulin, Marc J University of Calgary Cerebral blood flow regulation in obstructive sleep apnea. Sleep disordered breathing, chronic intermittent hypoxia, cerebrovascular reactivity testing, endothelial function, stroke. 20062009 $21,000 $63,000 I, II, IV Gao, Guang Luo, Honglin St. Paul’s Hospital Role of the ubiquitin/ proteasome pathway in coxsackievirus-induced myocarditis. Coxsackievirus, myocarditis, ubiquitin/proteasome pathway, virus pathogenesis, cardiomyocytes. 20052008 $21,000 $63,000 I Gaskari, Seyed A Lee, Samuel S University of Calgary Role of endocannabinoid system in the genesis of cirrhotic cardiomypathy. Cardiomypathy, cirrhosis, endocannabinoids, signal transduction. 20042008 $21,000 $62,500 I Ghosh, Sanjoy Rodrigues, Brian B University of British Columbia Cardiac lipotoxicity of n-6 PUFA in acute diabetes. PUFA, cell death, heart, diabetes, glutathione. 20052007 $3,500 $24,500 I Gordon, Grant RJ University of Calgary Global enhancement of glutamate synapses by glial cell networks. Magnocellular neuroendocrine cells (MNCs), vasopressin, hypothalamus, noradrenaline, glial cells. 20062007 $10,500 $10,500 I Bains, Jaideep Singh Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Pharmacogenomics, angiotensin I-converting enzyme inhibitors, quantitative trait, susceptibility loci, kinin metabolism. III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 65 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Graham, Drew Rush, Aaron James WE University of Waterloo Mechanisms in vascular nitric oxide bio-availability in chronic hypertension and exercise training. Hypertension, exercise, endothelial function, nitric oxide, oxidative stress. 20052009 $21,000 $63,000 I Harder, Christopher John McPherson, Ruth University of The role of hepatic SR-BI Ottawa Heart trafficking in reverse cholesterol Institute transport. SR-BI, HDL, heart disease, reverse cholesterol transport, intracellular trafficking. 20062007 $21,000 $21,000 I Hogue, JeanCharles Couture, Patrick Université Laval Effets de l’atorvastatine ou du Lipoprotéines, athérosclérose, fénofibrate chez les diabétiques diabète, statine, fibrate. hypertriglycéridémiques. 20052008 21 000 $ 63 000 $ I, II, IV Hunter, Arwen Granville, L David J St. Paul’s Hospital Cytochrome p450 2C enzymes in peri-transplant ischemic injury and transplant vascular disease. Ischemia, cytochrome p450, allograft, arteriosclerosis, endothelium. 20062009 $21,000 $63,000 I Iyirhiaro, Grace O Park, David S University of Role of Pin1 in reactivation of Ottawa Heart cell cycle proteins following Institute stroke injury. Stroke, apoptosis, cell cycle, cdks. 20062009 $21,000 $63,000 I Jeyaraman, Madhumathy Kardami, Elissavet University of Manitoba Role of connexin43 in protein kinase C mediated cardioprotection. Connexin43, protein kinaseC, ischemia and CX43, PKC and cardioprotection. 20052009 $19,250 $63,000 I Jimenez, Sarah Cattini, Peter A University of Manitoba Genetic regulation of cardioprotective fibroblast growth factors in the adult heart. Genetic regulation, cardioprotective FGF, transgenic. 20032007 $3,500 $61,167 I Khairallah, Maya Des Rosiers, Christine Institut de cardiologie de Montréal Metabolic interventions targeting the dystrophic heart: the potential benefits of medium chain fatty acids. Cardiomyopathy, Duchenne muscular dystrophy, metabolic disorders, 13C mass isotopomer analysis, cardioprotective therapies. 20042007 $7,000 $41,333 I Kimmerly, Derek S Shoemaker, J Kevin University of Western Ontario Exercise and central autonomic control of cardiovascular function in human health and disease. Humans, hypertension, central autonomic centres, efferent sympathetic nerve activity, vascular control. 20042007 $10,500 $48,167 I Kisilevsky, Alexandra E Zamponi, Gerald W University of Calgary Dopamine receptor coupling to cav2.2 calcium channels. Cav2.2 channels, G-proteins, dopamine receptors, cerebral ischemia. 20052007 $21,000 $42,000 I Toronto General Hospital c-Myb dependent vascular smooth muscle cell differentiation. Embryonic stem cells, differentiation, vascular smooth muscle cells, c-myb, targeted tissuespecific transgene knock-in. 20032007 $10,500 $61,500 I Kolodziejska, Husain, Karolina Maria Mansoor 06-07 $ Total $* Theme Thème Lamont, Ryan E Childs, Sarah J University of Calgary PlexinD1 signalling in the developing zebrafish. Angiogenesis, vascular patterning, VEGF signalling. 20052009 $21,000 $63,000 I Laplante, Marc-André de Champlain, Jacques Université de Montréal Rôle de la voie ERK-MAPK dans l’hypertension induite par l’angiotensine. Hypertension, stress oxydatif, vaisseaux, p42/44 ERK-MAPK, angiotensine II. 20032007 179 $ 59 512 $ I Laroche, Genevieve Parent, Jean-Luc Université de Sherbrooke Role de l’interaction arrestinesGEFs de Arfl dans la fonction du récepteur TP. Recepteurs couples aux proteines G, thromboxane A2, petites proteines G, exocytose, arrestines. 20062008 21 000 $ 25 039 $ I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 66 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Leclerc, Patrice Guillemette, Université de Gaetan Sherbrooke Modulation de l’activité de liaison du récepteur AT1 par l’oxide nitrique. Récepteur AT1, oxide nitrique, S-nitrosylation, affinité de ligand, alkylation. 20032007 3 500 $ 61 167 $ I Leung, General Moody, Alan Sunnybrook Health Sciences Centre Magnetic resonance imaging of vulnerable plaque in the coronary artery tree. Magnetic resonance, heart attack, vulnerable plaque. 20062009 $21,000 $63,000 I, II Liang, Wenbin Ward, Michael E St. Michael’s Hospital The role of chloride channels in hypoxia induced pulmonary hypertension. Hypoxia, human pulmonary atrery smooth muscle, chloride channels. 20062009 $21,000 $63,000 I Liu, Zhen Yang, Decheng St. Paul’s Hospital IGTP-induced PI3K/Akt signaling Interferon-y-inducible pathway in coxackievirus B3GTPase, PI3K/Akt pathway, caused myocarditis and dilated caxsackievirus B3, myocarditis. cardiomyopathy. 20062009 $21,000 $63,000 I Ljubicic, Vladimir Hood, David A York University Effect of physical activity on the apoptotic susceptibility of the aged heart. 20052009 $21,000 $63,000 I, II Lussier, Marc Boulay, Guylain Université de Sherbrooke Implication de RNF24 dans la Biologie cellulaire, signalisation régulation des canaux calciques cellulaire, calcium intracellulaire, TRPCs. TRPC, canal. 20062009 21 000 $ 63 000 $ I Martin, Stéphane Guillemette, Université de Gaétan Sherbrooke Étude de la structure du récepteur AT1 et des changements conformationnels causant l’activation des GPCRs. Récepteurs couplés aux protéines G, angiotensine II, structure, enclave de liaison, mécanismes d’activation. 20052007 10 500 $ 3 500 $ I Nagareddy, Prabhakara Reddy McNeill, John H University of British Columbia Mechanisms of vascular dysfunction in diabetes, role of nitrosative stress. Diabetes, nitric oxide, cardiovascular dysfunction, blood pressure, nitrosative stress. 20062009 $21,000 $63,000 I Neuspiel, Margaret McBride, Heidi M University of Mechanism and function of Ottawa Heart mitochondrial derived vesicles. Institute Mitochondria, budding, MARi-1, fission, dynamin1. 20062009 $17,500 $42,000 I Pande, Jyoti Grover, Ashok K McMaster University Caloxins: Search for high affinity Calcium homeostasis, cell inhibitors. signaling, plasma membrane calcium pumps, drug discovery, mutagenesis. 20052009 $17,500 $63,000 I Papageorgiou, Floras, Peter John S Christopher Mount Sinai Hospital Participation of activated coagulation factor XII (FXIIa) in blood pressure regulation in chronic renal failure. Hypertension, chronic renal failure, coagulation factor XII, kallikrein-kinin system, nocturnal hemodialysis. 20062008 $21,000 $42,000 I, II Pop, Mihaela Wright, Graham Sunnybrook Health Sciences Centre Magnetic resonance guidance of radiofrequency ablation of cardiac arrhythmias. Cardiac arrhythmias, magnetic resonance imaging, radiofrequency ablation. 20042007 $21,000 $62,000 I Proulx, Christophe Leduc, Richard Université de Sherbrooke Étude de la structure/fonction du récepteur à l’urotensine II, UT. Récepteur UT, urotensine II, internalisation, désensibilisation, phosphorylation. 20052008 21 000 $ 63 000 $ I Pyke, Kyra E Tschakovsky, Queen’s Michael E University Stimulus response specificity of human endothelial function. Shear stress, nitric oxide, vasodilation, brachial artery. 20062008 $17,500 $21,000 I, II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Mitochondria, aging, cardiac muscle, apoptosis. III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 67 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Rezazadeh, Saman Fedida, David University of British Columbia Real-time voltage clamp fluorimetry to understand slow and fast gating modes of the Kvl.2 channel. Cardiovascular, action potential, ion channels, drug binding, fluorimetry. 20062008 $21,000 $24,500 I Ronald, John A Rutt, Brian K Robarts Research Institute Magnetic resonance imaging of a rabbit model of atherosclerosis. Atherosclerosis, cholesterol, rabbit, magnetic resonance imaging, contrast agents. 20052009 $21,000 $63,000 I Rose, Patricia Anne Hudson, Chris Toronto Western Hospital Age-related changes in retinal vascular autoregulation in normal and atherosclerotic patients. Autoregulation, atherosclerosis, flowmetry, retina, statins. 20032007 $3,500 $61,167 II Ruffell, Brian H Johnson, Pauline University of British Columbia Monocyte recruitment to inflammatory sites. Inflammation, monocytes, macrophages, hyaluronan, CD44. 20062007 $21,000 $21,000 I Saini, Harjot K Dhalla, Naranjan S St. Boniface G.H. Research Centre Role of angiotensin II in subcellular remodelling in adult cardiomyocytes. Adult cardiomyocytes, cardiac gene expression, sarcoplasmic reticular proteins, myofybrillar proteins, angiotensin II receptors. 20042007 $21,000 $62,000 I Sauvageau, Stéphanie Thorin, Eric Institut de cardiologie de Montréal Functional characterization of the dimerization and intracellular trafficking of endothelin receptors. Endothelin receptors, heterodimerization, intracellular trafficking, endothelin antagonists, pulmonary hypertension. 20062009 $21,000 $63,000 I Shamloul, Rany Wang, Rui University of Role of heme oxygenase/ Saskatchewan carbon monoxide systems in hypertension development. 20062007 $10,500 $10,500 I Sharif, Reza N Bourque, Charles W Montreal General Hospital Molecular mechanisms of osmoreception in the hypothalamus. Osmoreception, vasopressin, supraoptic, neuroendocrine, hypothalamus. 20052007 $15,999 $33,499 I Singh, Raja B Dhalla, Naranjan S St. Boniface G.H. Research Centre Role of Protease Activation in Subcellular Remodeling in the Heart. Heart, ischemia-reperfusion, calpain, nitric oxide, sarcolemma. 20052008 $21,000 $63,000 I Sirinyan, Mirna Chemtob, Sylvain McGill University Retinal endothelial cytotoxic effects of sustained hypercapnia in retinopathy of prematurity. Retinopathy of immaturity, hypercapnia, microvascular degeneration, endothelial cell death, reactive nitrogen species. 20042007 $21,000 $62,000 I Song, Dongzhe Pang, Catherine CY University of British Columbia Effects of chronic Nacetylcysteine on insulin resistance and blood pressure. Antioxidant; insulin resistance; hypertension; fructose. 20042007 $21,000 $62,000 I Steinback, Craig D Shoemaker, J Kevin University of Western Ontario Baroreflex-chemoreflex interactions and sympathetic nerve activity in cardiovascular disease developement. Baroreceptors, chemoreceptors, sympathetic nerve activity, intermittent hypoxia, hypertension. 20052009 $21,000 $63,000 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 68 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Trudel, Eric Bourque, Charles W Montreal General Hospital Central mechanism underlying circadian variations in the osmoregulation of vasopressin. Synaptic communication, slices, patch-clamp, supraoptic nucleus, Organum vasculum lamina terminalis. 20042007 $21,000 $62,000 I van der Veer, Eric P Pickering, J Geoffrey University of Western Ontario Regulation of smooth muscle cell longevity by pre-cell colony-enhancing factor. Vascular biology, smooth muscle cells, aging, NAD. 20062008 $17,500 $26,250 I Vasudevan, Harish McNeill, John H University of British Columbia Androgen-dependent regulation of arachidonic acid metabolism influences the development of hypertension following insulin resistance. Insulin resistance, hypertension, sex hormones, endothelium derived hyperpolarizing factor (EDEF), 20-hydroxyeicosatetranoic acid (20-HETE). 20062009 $21,000 $63,000 I Wassef, Hanny Davignon, Jean Clinical Research Institute of Montreal The role of apolipoprotein C-I in adipose tissue. Adipocyte, apolipoprotein C-I, fatty acid metabolism, adipokine, oxidation. 20062009 $21,000 $63,000 I, II Weissgerber, Tracey L Adams, Michael A Queen’s University Effects of pregnacy, physical activity and preeclampsia on endothelial function and biochemical indices of oxidative stress and placental dysfunction. 20062008 $21,000 $42,000 I, II Xu, Yong Krukoff, Teresa L University of Alberta Physiological and molecular mechanisms for cardiovascular effects of adrenomedullin in the brain. Adrenomedullin, arterial pressure, baroreflex, nitric oxide, calcium. 20052007 $9,250 $30,250 I Zhang, Yun Zhang, Xia University of Ottawa Institute of Mental Health Research Poststroke treatment with cannabinoid, neuronal regeneration, stem/progenitor cells. Ischemic stroke, cannabinoid, neuronal regeneration, stem/ progenitor cells. 20062010 $10,500 $63,000 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 69 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Research Fellowships | Bourses de perfectionnement en recherche Awardee Supervisor Institute Project Keywords Term 06-07 $ Total $* Theme Récipiendaire Directeur Institut Projet Mots-clés Durée Akhavan, Armin Lingappa, Vishwanath University of California Subcellular mechanisms involved in biogenesis and secretion of Apolipoprotein B. Translocation, signal sequence, ApoB, biogenesis, arteriosclerosis. 20042007 $20,000 $79,000 I AugerMessier, Mannix Molkentin, Jeffrey D Cincinnati Children’s Hospital Medical Center Quels rôles jouent respectivement les deux isoformes de la calcineurin A dans l’hypertrophie physiologique et pathologique du coeur? Calcineurin, NFAT, système Cre-Lox, hypertrophie cardiaque, cardiomyopathies. 20052007 40 000 $ 80 000 $ I Boivin, Benoit Tonks, Nicholas K Cold Spring Harbor Laboratory Role of ROS and PTPs in RTKs transactivation by GPCRs. Hypertension, protein tyrosine phosphatases, reactive oxygen species, G-protein coupled receptors, receptor tyrosine kinases. 20062008 $40,000 $80,000 I Brown, Robert J Rader, Daniel J University of Pennsylvania Characterization of endothelial lipase exon variants associated with elevated HDL cholesterol. Polymorphisms, adenoassociated virus, atherosclerosis, lipoproteins, lipases. 20062009 $20,000 $80,000 I Busseuil, David Tardif, JeanClaude Institut de cardiologie de Montréal Étude de la physiologie des cellules endotheliales progénitrices chez les patients obèses métaboliquement normales. Cellules endotheliales progenitrices, atherosclerose, obeses metaboliquement en sante, stress oxydatif, risque cardiovasculaire. 20062008 40 000 $ 80 000 $ I, II, IV Chen, Yu Noble, Earl University of Western Ontario The “danger signal” hypothesis: Heart failure, myocardial a study on the role of infarction, inflammation, heat extracellular heat shock proteins shock proteins, immunity. in triggering cardiovascular inflammation. 20062007 $40,000 $40,000 I Corteling, Randolph L Welsh, Donald G University of Calgary The role of heteromeric G-proteins in the regulation of cerebral arterial tone. RNA interference, intact vessels, G-proteins, Calcium waves, contractions 20052007 $16,667 $36,667 I Coutu, Pierre Nattel, Stanley Montreal Heart Institute Role of T-type calcium channel in normal and diseased heart. Cardiac hypertrophy, T-type calcium channels, calcium homeostasis, electrophysiology, mathematical model. 20062007 $5,000 $5,000 I Cummings, Kevin James Wilson, Richard JA University of Calgary Hypertension and peripheral chemoreceptors: mechanisms behind post-hypoxic decline in carotid body activity. Hypertension, breathing, carotid body, neurotransmitters, apnea. 20042007 $20,000 $79,000 I DawsonScully, Kenneth Donald Sokolowski, Marla B University of Toronto cGMP dependent protein kinase, synaptic transmission and food related behaviours of drosophila. Drosophila melanogaster, synaptic transmission, cGMP, PKG, feeding behaviour. 20052007 $40,000 $80,000 I Dolinsky, Vernon Dyck, Jason University of RB Alberta AMPK activation for the treatment of insulin resistance. Skeletal muscle metabolism, AMPK, insulin resistance, diabetes. 20062008 $40,000 $80,000 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 70 Thème Heart and Stroke Foundation | Research Report 2006-2007 Awardee Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Duez, Hélèn Lewis, Gary F Toronto General Hospital The effect of dipeptidyl peptidase (DPP)-IV inhibition on carbohydrate and lipid metabolism. Diabetes, insulin secretion, GLP-1, incretins, dipeptidyl peptidase (DPP) IV inhibitor. 20052007 $40,000 $80,000 I Duhamel, Todd A Dhalla, Naranjan S St. Boniface Characterization of disease G.H. Research mechanisms associated with Centre diabetic cardiomyopathy induced by type 2 diabetes. Diabetic cardiomyopathy, cardiovascular disease, cellular remodelling, calcium regulation, protein phosphorylation. 20062009 $33,333 $80,000 I Dupre, Denis J Hébert, Terence E Montreal Heart Institute Characterization of the ontogeny and trafficking of G-protein coupled receptor complexes. G-protein coupled receptors, hetero-dimerization, trafficking, complex assembly, bioluminescence resonance energy transfer technology. 20052007 $40,000 $73,333 I El-Hamamsy, Ismail Yacoub, Magdi H Imperial College London Molecular and cellular responses to mechanical forces in the pulmonary valve. Heart valves, tissue engineering, interstitial cells, myofibroblasts. 20062007 $16,667 $16,667 I, II Fan, Xiaohu West, Lori J Hospital for Sick Children Induction of B cell tolerance to ABH blood group antigens by gene therapy. ABO-incompatible heart transplantation, B cell tolerance, gene therapy, lentiviral vector, human ABO blood type A transgenic mice. 20052007 $40,000 $80,000 I Gélébart, Pascal Michalak, Marek University of Alberta Calreticulin and cardiac development. Cardiac differentiation, stem cells, calreticulin, Ca homeostasis. 20042007 $20,000 $79,000 I Hale, Taben M deBlois, Denis Université de Montréal Therapeutic apoptosis confers long-term protection against target organ damage. Apoptosis, hypertension, stroke, myocardial infarction, fibrosis. 20062009 $30,000 $80,000 I Hurtado, Cecilia De Robertis, Edward M Howard Hughes Medical Institute Gene-enhanced therapies for ischemic heart disease. 20042007 $20,000 $79,000 I Jaffe, Ronen Strauss, Bradley H St. Michael’s Hospital Microvessel formation in chronic total occlusions: pathophysiology and role in guide-wire crossing. Magnetic resonance imaging, micro CT, chronic total occlusion, cell therapy, percutaneous coronary angioplasty. 20062007 $50,000 $50,000 I, II Javeshghani, Danesh Touyz, Rhian M Institut de recherches cliniques de Montréal Development of hypertension in follitropin receptor knockout mouse, potential implications for women’s health. Cardiovascular, oxidative stress, estrogen, angiotensin II, hypertension. 20042007 $20,000 $79,000 I Jung, Eubanks, James H Toronto Western Research Institute Characterization of GIG-11, a novel ischemia-induced gene, in neurodegeneration. Protein-interactions, phosphorylation, signal transduction, apoptosis. 20042007 $38,333 $79,917 I St. Michael’s Hospital Endothelial cell apoptosis in Pulmonary arterial hypertension, pulmonary arterial hypertension. endothelium, apoptosis. 20062008 $40,000 $80,000 I Benjamin Supervisor Fondation des maladies du cœur | Rapport de recherche 2006-2007 Jurasz, Paul K Stewart, Duncan J Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 71 Heart and Stroke Foundation | Research Report 2006-2007 Awardee Supervisor Fondation des maladies du cœur | Rapport de recherche 2006-2007 Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Karasinska, Joanna Monika Hayden, Michael R University of British Columbia Role of neuronal and glial ABCA1 in the response to neuronal injury. Cholesterol, ATP-binding cassette transporter, brain lipid metabolism, neuronal repair, animal model. 20062009 $33,333 $80,000 I Kinobe, Robert T Melo, Luis G Queen’s University Investigations of distinctive neuroprotective role of heme oxygenase isozymes in cerebral ischemia. Carbon monoxide, heme oxygenase, cerebral ischemia, stroke. 20062009 $16,667 $80,000 I, II, III, IV Koonen, Debby Dyck, Jason University of RB Alberta The role of FAT/CD36 in the regulation of fatty acid utilization in the heart. CD36, AMPK, ischemia/ reperfusion, fatty acid uptake, heart. 20052007 $40,000 $80,000 I Lee, SangWook Steinman, David A Robarts Research Institute Beyond normal: turbulence at the diseased carotid bifurcation and risk of stroke. Stroke, stenosis, blood flow dynamics, carotid artery, doppler ulatrasound. 20062008 $40,000 $66,667 I, II Lehmann, Hugo E Sutherland, Robert J University of Lethbridge The effects of hippocampal neural death and regrowth on memory. Neuronal death, hippocampus, memory, neurogenesis. 20052008 $40,000 $80,000 I, II Lin, Danny Chi-Chia Kaplan, David Hospital for Sick Children High-throughput shRNA screening to identify regulators of dendrite formation in cortical neurons. Dendrite formation, high-throughput screening, regeneration. 20062008 $40,000 $80,000 I Lynch, Jeffrey Molkentin, M Jeffrey D Children’s Medical Center Determination of the role of MEF2A and MEF2D in cardiac hypertrophy. Cardiac hypertrophy, myocyte enhancer factor 2 (MEF2), transcription. 20052008 $40,000 $80,000 I Mungrue, Imran Lusis, Aldons J University of California Examination of the role of TXNIP in atherosclerosis and lipid metabolism. Atherosclerosis, TXNIP, mouse models, protein building, mechanisms of metabolic disease. 20062008 $40,000 $80,000 I Naus, Silvia Ziltener, Hermann J University of British Columbia The role of metalloproteases in the leukocyte homing process. Metalloproteases, ADAM, mucin-like receptors, immune cells. 20062009 $20,000 $80,000 I Palanivel, Rengasamy Sweeney, Gary York University Regulation of carbohydrate and lipid uptake in cardiomyocytes by adiponectin. Obesity, heart failure, cardiac remodeling, adiponectin, metabolism. 20062008 $40,000 $80,000 I Pulinilkunnil, Thomas Chacko Kahn, Barbara B Beth Israel Deaconess Medical Center Role of the AMPK pathway and upstream kinases in the metabolic effects of adipokines and adrenergic agonists in white adipose tissue. AMPK, type 2 diabetes, obesity, CAMKK, heart. 20062008 $40,000 $80,000 I Qu, Yang (Tiffany) Tibbits, Glen F Simon Fraser University The automaticity of mouse embryonic stem cell derived cardiomyocytes. Embryonic stem cells, cardiac differentiation, pacemaker channels, targeted gene deletion, sodium/calcium exchanger. 20062008 $40,000 $80,000 I Rose, Robert A Backx, Peter H University of Toronto Role of P13Kinase-gama in heart rate regulation and in heart disease. Ion channels, heart disease, contractility, calcium, transgenics, mouse. 20052007 $40,000 $80,000 I, II Ruest, LouisBruno Clouthier, David E University of Louisville Endothelin-A receptor signalling during cardiac neural crest cell development. Cardiac neural crest cell, knockout mice, DNA microarray, antagonist, development. 20042007 $6,667 $78,333 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 72 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Awardee Supervisor Fondation des maladies du cœur | Rapport de recherche 2006-2007 Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Sapieha, Przemyslaw Chemtob, Sylvain McGill University Secretory phospholipase A2 receptors in ischemic neuropathies. Secretory phospholipase A2, vascular degeneration, inflammatory mediators, ischemic retinopathies, oxidative stress. 20062008 $40,000 $80,000 I Sidhu, Ranjinder S Smith, William L University of Michigan Cyclooxygenase pathways and omega-3 fatty acids. Cyclooxygenase, peroxidase, catalysis, mechanism. 20062008 $40,000 $80,000 I Silverman Gavrila, Lorelei B Charlton, Milton P University of Toronto The role of synaptic plasticity and phosphorylation in neruoprotection and survival from ischemic cerebellar stroke. Ischemic stroke, cerebellum, phosphorylation, synaptic plasticity, neuroprotection and survival. 20062008 $40,000 $80,000 I, II Singaraja, Roshni R Hayden, Michael R University of British Columbia The role of palmitoylation in the functional activity of ABCA1. Palmitoylation, lipid, atherosclerosis, efflux, trafficking. 20052007 $40,000 $80,000 I Storbeck, Sabourin, Christopher J Luc A University of Ottawa Investigation of the role of CLIM 2 in MLP mediated cardiomyopathy. Hypertrophy, dilated cardiomyopathy, MLP, CLIM2. 20052008 $40,000 $80,000 I, II, IV Tedford, Hugo W Zamponi, Gerald W University of Calgary Molecular determinants of Gprotein mediated regulation of N-type calcium channels. Calcium channel, electrophysiology, pain management, heterotrimeric G proteins. 20052007 $36,667 $70,000 I, II Tilley, Douglas G Rockman, Howard A Duke University The role of phosphoinositide 3 kinase in the beta-adrenergic receptor-mediated transactivation of epidermal growth factor receptor in the normal and failing heart. Heart failure, beta adrenergic receptors, epidermal growth factor receptor, transactivation, phosphoinositide 3 kinase. 20062008 $40,000 $80,000 I Varela Lekanda, Diego Ernst Zamponi, Gerald W University of Calgary Molecular determinants of T-type Biophysic, electrophysiology, calcium channel inactivation and calcium channel. its physiological significance. 20062009 $33,333 $80,000 I Vieira, Luciene Bruno Zamponi, Gerald W University of Calgary Modulation of N-type calcium channel function by the small GTPase Rem2. 20062008 $20,000 $33,333 I Xaymardan, Munira Li, Ren-Ke University of Toronto Pretreatment of bone marrow Myocardial infarction, bone cells with VEGF and FGF marrow, cardiac regeneration, augments the myogenic diffeVEGF, FGF. rentiation and engraftment of the cells into infarcted myocardium. 20062009 $3,333 $80,000 I Yang, Guangdong Wang, Rui University of The physiological role of Saskatchewan endogenous hydrogen sulfide in the regulation of smooth muscle cell proliferation and apoptosis. Hydrogen sulfide, vascular smooth muscle cells cystathionine gamma-lyase, proliferation, apoptosis. 20052008 $40,000 $80,000 I Zhang, Yiqiang Marban, Eduardo Johns Hopkins University Cardiac stem cell, electrophysiology, developmental cell biology, cardiac marker genes, cardiac infarction. 20062008 $40,000 $80,000 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale Developmental ionic and molecular basis of cardiac stem cells in cardioregeneration. II: Clinical II : Clinique Patch-clamp, confocal microscopy, electrophysiology, calcium channels, synaptic transmission. III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 73 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 New Investigators | Bourses de nouveaux chercheurs Awardee Institute Project Keywords Term Projet Mots-clés Durée Poly(ADP-ribose) polymerase, excitotoxicity, astrocytes, glutamate transport. 06-07 $ Total $* 20052010 $50,000 $250,000 I Barber, Philip University of Magnetic resonance molecular imaging Stroke, magnetic resonance imaging, A Calgary (MRMI) of the early endothelial neuroinflammation. inflammatory response in focal ischemia. 20052010 $50,000 $265,000 I Childs, Sarah J University of Blood vessel development in zebrafish. Calgary Angiogenesis, development, zebrafish, genomic, molecular biology. 20012007 $4,167 $250,000 I Colicos, Michael A University of Role of neuroligin during Calgary photoconductive stimulation-driven synaptic reorganization of mammalian neuronal networks. Ischemia, synaptic reorganization, neuronal cultures, neurosilicon interface, neuroligin. 20062011 $65,000 $265,000 I Czubryt, Michael P University of Roles of MEF2 and HDAC5 in cardiac Manitoba failure and hypertrophy. Transcriptional regulation, cardiac hypertrophy, molecular biology, sexual dichotomy, transgenic mice. 20042009 $50,000 $265,000 I Dawson, John F University of Characterization of human cardiac actin Cardiac actin mutations, hypertrophic Guelph mutations linked to hypertrophic and and dilated cardiomyopathy, protein dilated cardiomyopathies. expression and manipulation, actin binding assays. 20042010 $50,000 $250,000 I Devlin, Angela M University of British Columbia Nutrition, epigenetics & risk for cardiovascular disease. Hyperhomocysteinemia, DNA methylation, mice, nutrition, gene expression. 20062011 $65,000 $265,000 I, II, IV Drolet, Benoit Université Laval The modulating effects of diabetes, obesity and genetics on the electrophysiology of QT-prolonging drugs. Electrophysiology, obesity, diabetes, patch-clamp, TW-prolonging drugs. 20042009 $50,000 $250,000 I FernandezPatron, Carlos A University of New vasoconstrictor mechanism Alberta triggered by transactivation of a growth pathway. Vascular, epidermal growth factor receptor, transactivation, G-protein coupled receptor. 20022007 $50,000 $250,000 I Gramolini, Anthony University of Molecular basis of PLN regulation and Toronto function in cardiac muscle. Calcium, serca, mouse models, phospholamban, cardiac, sarcoplasmic reticulum. 20062011 $50,000 $250,000 I, II Jacques, Danielle Université de Sherbrooke Regulation of intracellular calcium by NPY in endocardial endothelial cells. Neuropeptide Y, endocardial endothelium, confocal microscopy, receptor mapping, intracellular calcium. 20022008 $50,000 $250,000 I Liaw, Patricia CY McMaster University Modulation of inflammation and apoptosis by activated protein C, a natural anticoagulant. Coagulation, inflammation, apoptosis, thrombosis, activated protein C, vascular biology, endothelial cells, blood monocytes, leukocytes, signal transduction pathways, proteaseactivated receptors, biochemistry, cell biology, molecular biology, translational studies of patient blood samples, in vivo animal models. 20032009 $50,000 $250,000 I Récipiendaire Institut Anderson, Christopher M University of PARP1 effects on bioenergetics and Manitoba glutamate homeostasis in brain. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 74 Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Awardee Institute Récipiendaire Institut Fondation des maladies du cœur | Rapport de recherche 2006-2007 Project Keywords Term Projet Mots-clés Durée 06-07 $ Total $* Theme Thème MacDonald, Justin A University of Characterization of CHASM Calgary involvement in cGMP-evoked calcium desensitization in vascular smooth muscle. Calcium desensitization, smooth muscle tone, nitric oxide, cGMPdependent protein kinase, signal transduction. 20042009 $50,000 $250,000 I Mak, Susanna Mount Sinai Hospital Estrogen and cardiac function in humans with and without heart failure. Sex, estrogen, ventricular function, heart failure. 20052010 $50,000 $250,000 II Melacini, Giuseppe McMaster University Structural basis for the cAMP-signal translation in PKA by NMR. Signalling, kinase, cAMP, allostery, NMR. 20062011 $50,000 $250,000 I Melo, Luis G Queen’s University Gene therapy for long term myocardial protection and rescue. Myocardium, echocardiography, hemodynamic measurements, histology. 20022007 $50,000 $250,000 I Miller, Gregory E University of British Columbia Depression, inflammation, and risk for coronary heart disease. Depression, behavioral cardiology, inflammation, coronary heart disease, metabolic syndrome. 20052010 $50,000 $265,000 II, IV Pasumarthi, Kishore Babu S Dalhousie University Isolation and characterization of cardiac Transgenic mice, embryonic stem progenitor cells. cells, cardiac progenitor cells, gene expression, cardiac repair. 20032008 $50,000 $250,000 I Peng, Tianqing Lawson Research Institute PLCgamma/IP3 signaling regulates cardiac TNF-a expression in sepsis. Sepsis, TNF-alpha, cardiomyocyte, phospholipase Cgamma, inositol trisphosphate. 20062011 $50,000 $250,000 I Pyle, William Glen University of The role of cardiac Z-disc in signal Guelph transduction and myocardium. Actin capping protein, intracellular signalling, muscle mechanics, cytoskeleton, heart failure. 20052010 $50,000 $250,000 I Reid, Robert D University of Interventions to promote physical Ottawa activity for the secondary prevention of CAD. Physical activity, CAD. 20022007 $50,000 $250,000 IV Rodger, Marc A University of Thrombophilia: novel associations and Ottawa therapeutic interventions. Thrombophilia, pregnancy, randomised controlled trial, hemodialysis access, thrombosis, case control study. 20022007 $50,000 $250,000 II Trigatti, Bernardo L McMaster University Effect of tissue specific expression or suppression of the HDL receptor SR-BI on cardiovascular disease. Transgenic, knockout, HDL receptor, atherosclerosis, coronary artery disease. 20022007 $50,000 $250,000 I Wang, Hui Di Brock University Vascular gp-91phox containing NADPH oxidase in angiotensin II-induced hypertension. NADPH oxidase, angiotensin II, endothelin-1, hypertension, hypertrophy. 20022007 $50,000 $250,000 I Werstuck, Geoffrey H McMaster University Mechanisms by which diabetes mellitus promotes the development and progression of atherosclerosis. Atherosclerosis, diabetes mellitus, endoplasmic reticulum, molecular and cellular biology, mouse models. 20042009 $50,000 $250,000 I Zha, Xiaohui Ottawa Hospital Research Institute ABCA1 and molecular mechanism of cholesterol efflux. ABCA1, cholesterol, fluorescent microscopy, membrane, trafficking. 20032008 $50,000 $250,000 I Zhang, Shetuan St. Boniface G.H. Research Centre The mechanisms of sudden cardiac death caused by cocaine. Myocardium, emergency cardiac care, electrophysiology, molecular biological techniques, cardiac dysrrhythmias. 20042008 $50,000 $183,333 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 75 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Visiting Scientist | Bourse de chercheur invité Awardee Sponsor Récipiendaire Parrain de la Institute Project Keywords Term Institut Projet Mots-clés Durée University of British Columbia Contribution of gap junctional communication in the neuroprotective role of astrocytes. Stroke, neuroprotection, astrocytes, gap junctions, connexin. 06-07 $ Total $* Theme Thème demande Naus, Christian Giaume, Christian 20062007 $8,200 $8,200 I Nursing Research Fellowships | Bourses de perfectionnement en sciences infirmières Awardee Supervisor Institute Project Keywords Term Récipiendaire Directeur Institut Projet Mots-clés Durée Carroll, Sandra Lee Arthur, Heather M McMaster University Uncertainty and optimism in patients receiving implantable defibrillators. Implantable defibrillators, uncertainty, optimism, quality of life. 20052008 $25,000 $75,000 II Lapum, Jennifer L Angus, Jan E University of Toronto Narratives of technological health care: patients’ reconstruction of selfidentity following open-heart surgery. Heart surgery, experiences, technology, self-identity, narratives. 20052008 $25,000 $75,000 II Lauck, Sandra B Johnson, Joy University of British Columbia How does early discharge following elective same-day discharge angioplasty affect patient outcomes? Coronary artery disease, percutaneous coronary intervention (PCI), early discharge, patient outcomes. 20062008 $25,000 $50,000 II, III McLean, Donna L Tsuyuki, Ross T University of Alberta Detection and management of hypertension in patients with diabetes in the community. Detection, management, hypertension, diabetes, community. 20042007 $25,000 $75,000 III Parry, Monica JE WattWatson, Judy University of Toronto Impact of a home-based intervention on health-related quality of life, function, and symptom management for people following coronary artery bypass graft surgery. Health related quality of life (HRQOL), peer support, symptom management, functional status, coronary artery bypass graft surgery. 20042007 $25,000 $75,000 II University of Toronto Can structured-coaching increase intake Cardiac rehabilitation, and uptake of cardiac rehabilitation in access, women. female cardiac patients? 20062009 $25,000 $75,000 II, III Price, Jennifer Doran, AD Diane *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 76 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Industry-Supported Research Personnel Awards Bourses de fonctionnement en recherche financées par l’industrie The HSF wishes to thank the following industry supporters for their generous contributions to support the HSF Research Program. La FMC souhaite remercier les entreprises suivantes pour leur généreuse contribution au soutien de son programme de recherche. Awardee Supervisor Récipiendaire Directeur Institute Project Keywords Institut Projet Mots-clés Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $ HSF FMC Total $ (All Partners) (tous les partenaires) Theme Thème HSF/CIHR/AstraZeneca Clinical Research Fellowship | Bourse de perfectionnement en recherche clinique FMC/IRSC/AstraZeneca Casaubon, Leanne K Kapral, Moira K Toronto General Hospital Evaluation of the effect of acute hyperglycemia on stroke outcomes. Stroke, hyperglycemia, outcomes research, registries, data linkage. 20062007 $16,667 $50,000 $16,667 $50,000 II, III Koshy, Susan M Logan, Alexander G Mount Sinai Hospital Predictors of cardiovascular outcomes and death in pediatric renal transplant recipients. Myocardial infarction, stroke, renal transplant, pediatric, longitudinal. 20062008 $16,667 $50,000 $22,222 $66,667 II HSF/AstraZeneca Research Fellowship | Bourse de perfectionnement FMC/AstraZeneca Bussiere, Miguel Hachinski, Vladimir University of Western Ontario Cerebral and systemic consequences of carotid stenting. Karwatsky, Joel Zha, Xiaohui Ottawa Health Research Institute The influence of ATP-binding cassette protein A1 (ABCA1) on cholesterol export. Lapointe, Benoit Kubes, Paul University of Calgary In vivo leukocyte trafficking and emigration in a model of stroke. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Carotid, stenting, physiology, autonomic, cognition. 20062008 $0 $50,000 $0 $100,000 I, II Cholesterol, 20062009 $0 $33,333 $0 $80,000 I 20052008 $30,000 $40,000 $40,000 $80,000 I coronary heart disease, membrane trafficking, ABC transporters, ATP-binding cassette protein A1 (ABCA1). Stroke, chemotaxis, emigration, recruitment, leukocyte. III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 77 Heart and Stroke Foundation | Research Report 2006-2007 Awardee Supervisor Fondation des maladies du cœur | Rapport de recherche 2006-2007 Institute Project Keywords Récipiendaire Directeur Institut Projet Mots-clés Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $ HSF FMC Total $ (All Partners) (tous les partenaires) Theme Maekawa, Yuichiro Liu, Peter P Toronto General Hospital Roles of interleukin-1 signaling pathways in left ventricular remodeling after acute myocardial infarction. Heart failure, myocardial infarction, knockout models, cytokines, immunity. 20062008 $0 $40,000 $0 $51,667 I, II Overgaard, Christopher B Newton, Gary E University of Toronto Free radical modulation of mechanical efficiency in heart failure. Heart failure, free radicals, mechanical efficiency. 20052008 $25,000 $50,000 $50,000 $100,000 II Thème HSF/Great-West Life and London Life Research Award | Bourse de recherche FMC/Great-West Life et London Life Whitman, Stewart C N/A University of Ottawa Heart Institute The role of the immune system in atherosclerosis: mechanism of action of IL-12 and IL-18. Atheros-clerosis, immunology, apoE-/- mouse, cytokines. 20032007 $60,000 $60,000 $120,000 $250,000 I $25,000 $25,000 $98,750 $146,250 II HSF/Merck Frosst Research Fellowship | Bourse de perfectionnement FMC/Merck Frosst Spears, Julian Wallace, M Christopher Toronto Western Hospital Development of a prediction model for neurological outcome following surgery of brain AVMs in the prevention of hemorrhagic stroke. Stroke, prevention, brain arteriovenous malformations, surgery, outcome measures. 20032007 HSF/Pfizer Canada Research Fellowship | Bourse de perfectionnement FMC/Pfizer Canada Comtois, Philippe Nattel, Stanley McGill University Role of tissue fibrosis in atrial fibrillation. Congestive heart failure, atrial fibrillation, mathematical modeling, epicardial mapping, tissue remodeling. 20062008 $0 $40,000 $20,000 $60,000 I Paquet, Maryse Ferguson, Stephen SG Robarts Research Institute Role of astrocytic and neuronal mGluR5 and GRK2-mediated desensitization in excitotoxicity. Excitotoxicity, GRK2, mGluR5, astrocytes, neurons. 20062007 $0 $36,667 $0 $36,667 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 78 Heart and Stroke Foundation | Research Report 2006-2007 Awardee Supervisor Récipiendaire Directeur Fondation des maladies du cœur | Rapport de recherche 2006-2007 Institute Project Keywords Institut Projet Mots-clés Term 06-07 $ Durée HSF FMC Total 06-07 $ (All Partners) (tous les partenaires) Total $ HSF FMC Total $ (All Partners) (tous les partenaires) Theme Thème HSF/Sanofi-aventis Research Fellowship | Bourse de perfectionnement FMC/Sanofi-aventis Bouchard, Luigi Vohl, Marie- Université Genomic insights Claude de Laval into the metabolic syndrome. Visceral obesity, DNA microarrays, differential gene expression. 20052007 $40,000 $40,000 $40,000 $80,000 I, IV $40,000 $40,000 $120,000 I HSF/Transamerica Life Canada Research Award | Bourse de recherche FMC/Transamerica Vie Canada Cimini, Massimo Li, Ren-Ke Toronto General Hospital Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale Construction of tissue engineered grafts for cardiac repair. II: Clinical II : Clinique Tissue engineered cardiac grafts, cardiomyocytes, smooth muscle cells, skeletal muscle cells, bone marrow derived mesenchymal stem cells. 20052008 $0 III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 79 APPENDIX Annexe C GRANTS-IN-AID BY PROVINCE SUBVENTIONS PAR PROVINCE Dr. Jean-Pierre Després (Hôpital Laval) was part of research teams in 2006-2007 receiving Grant-in-Aid awards from the Heart and Stroke Foundation of Québec, including an award titled Metabolic determinants of the progression of aortic stenosis. Dr Jean-Pierre Després (Hôpital Laval) faisait partie des équipes de recherche qui, en 2006-2007, étaient financées par la Fondation des maladies du cœur du Québec, notamment par l’entremise d’une bourse pour le projet Facteurs métaboliques de la progression de la sténose aortique. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 British Columbia/Yukon | Colombie-Britannique / Yukon 06-07 $ Total $* Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Accili, Eric A University of British Columbia Interactions among pacemaker channel isoforms and auxiliary proteins. Pacemaker channels, co-assembly, cell surface expression. 20062009 $125,000 $375,000 I, II Accili, Eric A University of British Columbia Molecular and cellular mechanisms of HCN channel function. Hyperpolarization-activated channels, structure-function, trafficking, gating, permeation. 20042007 $102,250 $303,274 I Burtnick, Leslie D University of British Columbia The structure of gelsolin-capped actin filaments. Actin, gelsolin, thymosin beta4, tropomyosin, x-ray crystallography. 20052008 $16,279 $48,284 I Church, John University of British Columbia Ischemia and the regulation of intracellular ion homeostasis in hippocampal neurons. Cerebral ischemia, intracellular ion homeostasis, sodium/ hydrogen exchange, chloride/ bicarbonate exchange, sodium/bicarbonate cotransport. 20052008 $54,497 $173,491 I Cupples, William A University of Victoria Consequences of the salt paradox in diabetes mellitus. Diabetes mellitus, blood pressure, autoregulation, nephropathy, salt paradox. 20052008 $42,322 $127,030 I Davies, Hugh W; Demers, Paul A; Ostry, Aleck S; Levy, Adrian R University of British Columbia Exposure to noise at work and cardiovascular disease: a study of the temporal association, interactions among exposure agents, and susceptible populations. 20052008 $46,778 $123,673 IV Eng, Janice J University of British Columbia Exercise programs in stroke. Rehabilitation, health services, upper extremity function, exercise, recovery. 20062009 $112,192 $336,504 III Fedida, David University of British Columbia Activation and inactivation gating of cardiac voltage-gated potassium channels studied by electrophysiology and time-resolved fluorescence changes. Potassium channel, heart, fluorescence, arrhythmia, electrophysiology. 20062011 $156,844 $750,680 I Fedida, David University of British Columbia Contribution of the dynein motor system to surface expression and subcellular localization of voltagegated potassium channels. Potassium channel, heart, dynein motor, arrhythmia, electrophysiology. 20052010 $122,740 $619,079 I Granville, David J; Laher, Ismail St. Paul’s Hospital Role of CYP2C9 in peri-transplant ischemic injury. 20052008 $72,529 $217,551 I Hayden, Michael R University of British Columbia The molecular mechanisms underlying the improved lipoprotein profile of LPL-S447X and its use for the treatment of lipoprotein lipase deficiency. 20042007 $12,954 $38,422 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 82 Lipoprotein lipase, gene therapy, triglycerides, HDL, cholesterol. Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur 06-07 $ Total $* Theme Thème co-chercheur(s) principal Hill, John S St. Paul’s Hospital Functional analysis of lipase gene expression in human macrophages. Endothelial lipase, hepatic lipase, macrophages, atherosclerosis, RNA interference. 20052008 $34,690 $102,855 I, II Hill, John S; Frohlich, Jiri J; Chan, Sammy Y St. Paul’s Hospital Evaluation of the relative predictive value of biomarkers of oxidative stress for cardiovascular mortality. Oxidative stress, risk factors, angiography, coronary artery disease, mortality. 20062008 $108,127 $216,218 I, II Humphries, Karin H; Kerr, Charles R; Bernstein, Victoria; Cook, Richard; Gin, Kenneth G; Slavik, Richard University of British Columbia Magnesium for the prevention of atrial arrhythmias after cardiac surgery (M-PAACS). 20042007 $63,000 $420,851 II Johnson, Pauline University of British Columbia To investigate the pro- and anti- inflammatory functions of CD44 and hyaluronan. Inflammation, cell adhesion molecules, CD44, hyaluronan, macrophages. 20062009 $80,490 $160,454 I Karsan, Aly BC Cancer Research Centre Mechanisms of ischemic neovascularization. Endothelial cells, vascular smooth muscle, endothelialmesenchymal transformation, notch, snail. 20042009 $108,470 $321,722 I Karsan, Aly BC Cancer Research Centre Molecular mechanisms of endothelial survival/apoptosis. Apoptosis, endothelium, notch, signal transduction, vascular injury. 20062011 $129,747 $129,747 I Krassioukov, Andrei V; Ramer, Matthew S; Norenberg, Michael D University of British Columbia Episodic hypertension following spinal cord injury: the role of peripheral sympathetic-sensory interactions in animal models and humans. Autonomic dysreflexia, blood pressure control, human, sympathetic preganglionic neurons, spinal cord injury. 20062009 $75,853 $209,005 I Laher, Ismail University of British Columbia Cigarette smoking and resistance artery function. Resistance artery, endothelium, myogenic tone, pharmacology, cerebral artery, signaling, coronary artery, calcium. 20042007 $91,413 $271,131 I Laher, Ismail University of British Columbia Lifestyle modifications improve coronary artery function in type 2 diabetes. Diabetes, endothelium, superoxides, coronary artery, mouse. 20062009 $87,528 $262,512 I, II, III, IV Leroux, Michel R Simon Fraser University Analysis of genes linked to cardiovascular disease. Bardet-Biedl syndrome, BBS proteins, Alstrom syndrome, cilia, cardiovascular health. 20052010 $98,711 $499,859 I MacLeod, Kathleen M University of British Columbia Activation of PKC and induction of iNOS in diabetic arteries: mechanisms and significance. Diabetes, vasoconstriction, PKC, rho kinase, iNOS. 20062007 $42,384 $42,384 I MacVicar, Brian A University of British Columbia Cellular mechanisms underlying ischemia induced neuronal necrosis. Brain slice, necrosis, pannexin, TRP channel, intracellular calcium. 20062009 $106,500 $319,500 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 83 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur 06-07 $ Total $* Theme Thème co-chercheur(s) principal McManus, Bruce M; Luo, Honglin St. Paul’s Hospital Intracellular signalling networks in cardiotropic enteroviral infections. Coxsackievirus B3, intracellular signalling networks, extracellular signal-regulated kinase, viral myocarditis, proinflammatory cytokine. 20062009 $100,400 $301,200 I McManus, Bruce M; Rahmani, Maziar ; Knight, Darryl A St. Paul’s Hospital Role and regulation of proteoglycan, versican, in vascular injury and repair. Beta-catenin, T cell factor transcription factors, vascular injury and repair, proteoglycans, and versican. 20052008 $85,000 $256,734 I McNagny, Kelly M University of British Columbia The role of endoglycan in hematopoiesis, vascular biology and cancer. CD34, adhesion, vascular permeability, cell migration. 20042007 $95,537 $283,363 I McNeill, John H University of British Columbia Modulation of cardiac metabolism by metoprolol in the diabetic heart. Cardiomyopathy, heart failure, cardiac metabolism, beta-blockers, diabetic complications. 20062009 $107,809 $323,427 I Miller, William C; Eng, Janice J University of British Columbia Fear of falling after stroke. Fear of falling, falling, stroke, aging, balance confidence. 20042007 $54,505 $173,448 II Moore, Edwin DW University of British Columbia The structure of excitationcontraction coupling in atrial and ventricular muscle. 20062009 $8,000 $23,928 I Murphy, Timothy H University of British Columbia Protection against neuronal oxida- Glutamate, oxidative stress, tive stress by glial glutathione. stroke, glutathione, glia. 20042007 $83,850 $248,699 I Naus, Christian CG; Krebs, Claudia University of British Columbia Gap junctions and neuroprotection in stroke. Gap junctions, transgenic, knockout, connexin, stroke. 20052010 $87,000 $431,934 I Pang, Catherine CY; Kuo, Kuo-Hsing University of British Columbia Pharmacology of vasoactive substances. In vivo, urocortin, blood pressure, venous system, morphology. 20062007 $42,384 $42,384 I Proud, Christopher G University of British Columbia Control of protein synthesis in cardiac myocytes. Signaling, mTOR, protein synthesis, cardiac hypertrophy, protein kinase. 20052008 $108,660 $331,910 I Pryzdial, Edward LG University of British Columbia Coagulation initiated on herpes viruses. Coagulation, fibrinolysis, herpes, thrombosis, biochemistry. 20062009 $112,884 $338,652 I Pryzdial, Edward LG University of British Columbia Effects of plasmin on prothrombinase. Coagulation, fibrinolysis, factor X, factor V, biochemistry. 20042007 $104,455 $309,814 I Rodrigues, Brian B University of British Columbia Cardiac abnormalities in n-6 PUFA fed diabetic rats. Polyunsaturated fatty acids, diabetes, cardiolipin, glutathione, necrosis. 20052008 $60,169 $180,507 I Sanatani, Shubhayan; Etheridge, Susan P; McCrindle, Brian W; Potts, James E; Stephenson, Elizabeth A BC Children’s Hospital A randomized, double-blind, multi-center study of antiarrhythmic medications in the treatment of infants with supraventricular tachycardia (SAMIS trial). Arrhythmia, supraventricular tachycardia, treatment, clinical trial, infants. 20062010 $111,420 $334,188 II, III, IV *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 84 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Steinbrecher, Urs P University of British Columbia Activation of macrophage growth and survival pathways by oxidized LDL. Tibbits, Glen F; Paetzel, Mark W Simon Fraser University Regulation of cardiac myofilament sensitivity to calcium. van Breemen, Cornelis ; Laher, Ismail St. Paul’s Hospital Walley, Keith R; Murkin, John M; Sandford, Andrew J; Russell, James A; Lichtenstein, Samuel V 06-07 $ Total $* Theme Thème 20042009 $141,658 $703,402 I Troponin C, design of calcium sensitizing drugs, cardiac contractility, familial hypertrophic cardiomyopathy. 20062009 $152,150 $456,378 I Cellular mechanisms of vascular dysfunction in human diabetes. Human vessels, diabetes, vasomotion, calcium imaging. 20042007 $103,740 $307,693 I University of British Columbia Genetic determinants of cognitive dysfunction following cardiopulmonary bypass. Cardiopulmonary bypass, genes, polymorphisms, cognitive dysfunction. 20042007 $180,000 $543,880 III Wang, Yu Tian University of British Columbia Investigation into the molecular mechanisms mediating excitotoxicity - developing novel post-stroke therapies. NMDA receptor, excitotoxicity, stroke, AMPA receptor, apoptosis. 20062011 $121,340 $606,664 I Wellington, Cheryl L University of British Columbia ABCG1, HDL metabolism, and atherosclerosis. ABCG1, cholesterol efflux, atherosclerosis, transgenic, lipid transport. 20052008 $115,980 $337,961 I Wright, Joanne L University of British Columbia Mechanisms of cigarette smoke-induced pulmonary hypertension. Endothelin, eNOS, vascular physiology, COPD, cigarette smoke, remodeling. 20062007 $42,384 $42,384 I Yang, Decheng St. Paul’s Hospital Mechanisms of apoptotic cell death induced by a newly isolated mBNip21 gene in coxsackievirus B3-infected mouse heart. Apoptosis, virus, host gene response, signal transduction, myocarditis. 20042007 $17,000 $50,422 I Yang, Decheng St. Paul’s Hospital Roles of viral protease genes and the mouse NAT1 gene. Myocarditis, coxsackievirus, death pathways, NAT1, apoptosis. 20042007 $59,659 $176,949 I Zehr, E Paul University of Victoria Utilization of spinal circuitry and cutaneous feedback for recovery of walking after stroke. Stroke, reflex, feedback, walking, central patterning, cutaneous. 20052009 $120,000 $475,848 I, II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 85 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Alberta/Northwest Territories/Nunavut | Alberta / Territoires du Nord-Ouest / Nunavut 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Anderson, Todd J Foothills Hospital HDL modulation and endothelial function. Endothelium, cholesterol, HDL, atherosclerosis, vascular biology. 20052008 $90,000 $180,000 II Barber, Philip A University of Calgary The characterisation of the neuroinflammatory endothelial response to ischemia/reperfusion by magnetic resonance molecular imaging (MRMI). Cerebral ischemia, neuroinflammation, magnetic resonance molecular imaging. 20042007 $49,000 $147,000 I Beaulieu, Christian University of Alberta Advanced MRI methods for brain evaluation in acute stroke. Magnetic resonance imaging, acute stroke, 20062009 $52,000 $52,000 I, II Braun, Andrew P University of Calgary Integrin signalling and regulation of Vascular contractility, large conductance, Ca-activated K+ integrin signalling, Cachannels in smooth muscle. activated K+ channels, tyrosine phosphorylation. 20042007 $49,000 $147,000 I Brindley, David N University of Alberta Regulation of smooth muscle cell migration and division by sphingosine 1-phosphate. Angiogenesis, atherosclerosis, EDG receptors, platelet derived growth factor, sphingosine-1-phosphate. 20052008 $49,000 $98,000 I Casey, Joseph R University of Alberta Cl / HCO3 Exchangers in cardiac ischemia and hypertrophy. Chloride / bicarbonate exchange, pH regulation, hypertrophy, ischemia, bicarbonate transport. 20052008 $52,000 $104,000 I Chen, SR Wayne University of Calgary Structure and function of the trout cardiac ryanodine receptor: insight into the molecular basis of spontaneous Ca2+ release. Cardiac arrhythmia, EC coupling, sarcoplasmic reticulum, Ca2+ release, ryanodine receptor, single channel recordings, cDNA cloning. 20052008 $57,000 $114,000 I Cheung, Po-Yin University of Alberta The use of supplemental oxygen in the resuscitation of asphyxiated newborns. Newborn, hypoxiareoxygenation, resuscitation, hemodynamics, swine. 20042007 $52,000 $156,000 I Childs, Sarah J University of Calgary Identifying genetic pathways for the Angiogenesis, development, susceptibility to hemorrhage during genetics, zebrafish, early development. hemorrhage. 20052008 $57,000 $114,000 I Cole, William C; Plane, Frances University of Calgary Role of endothelial small conductance Ca2+ activated K+ channels in delayed cerebral vasospasm in a rat model of subarachnoid hemorrhagic stroke. 20062009 $57,000 $57,000 I $ cumulatif reçu en 2007 diffusion, perfusion, sodium. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 86 Cerebral vasospasm, stroke, endothelium, SKCa channels, nitric oxide. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Demchuk, Andrew M; Green, Theresa L; Eliasziw, Michael Foothills Medical Centre Evaluation of magnetic resonance TIA, acute stroke, arterial imaging as a potential surroocclusion, MRI, prognosis. gate endpoint for future stroke. Intervention trials when compared to clinical outcomes in nondisabling minor stroke and TIA (VISION-2). 20062009 $49,000 $49,000 I, II, III, IV Duff, Henry J University of Calgary Genetic and environmental calcium interactions modulate the cellular LQT2 phenotype. Cellular calcium, ryanodine receptor, restitution of repolarization, postextrasystolic potentiation, T wave alternan. 20062009 $49,000 $49,000 I Dyck, Jason RB University of Alberta The effects of the PRKAG2 mutations on cardiac energy AMPK, glycogen, cardiac energy metabolism, 20052008 $57,000 $114,000 I metabolism. PRKAG2 mutations, WolffParkinson-White syndrome. $ cumulatif reçu en 2007 El-Kadi, Ayman O University of Alberta The role of cytochrome P450 family 1 enzymes in the development of cardiac hypertrophy. Arachidonic acids, cardiac hypertrophy, cytochrome P450, signaling pathways, oxidative stress. 20062009 $49,000 $49,000 I Francis, Gordon A University of Alberta Apolipoprotein-mediated lipid efflux from arterial smooth muscle cells. Apolipoproteins, smooth muscle cells, atherosclerosis, cholesterol, HDL. 20042007 $57,000 $171,000 I Frayne, Richard ; Mahallati, Houman Foothills Hospital Large Field of View (LFOV) Magnetic Resonance Angiography (MRA) for rapid assessment of Peripheral Arterial Disease (PAD). Magnetic Resonance Angiography (MRA), Peripheral Arterial Disease (PAD), vascular imaging, atherosclerosis. 20042007 $57,000 $171,000 I French, Robert J University of Calgary Molecular bases of sodium channel isoform-specific drug targeting. Sodium channels, conotoxins, channel block, drug specificity, antiarrhythmic / anticonvulsive / local anaesthetic. 20062009 $57,000 $57,000 I Goodyear, Bradley G University of Calgary Functional magnetic resonance imaging techniques to assess recovery after ischemic stroke. Functional magnetic resonance imaging, ischemic stroke, perfusion, functional recovery, functional reorganization. 20042007 $49,000 $147,000 I Haykowsky, Mark J; Tymchak, Wayne J University of Alberta Effects of exercise training on peak aerobic power, cardiovascular and musculoskeletal performance and quality of life in cardiac transplant recipients. Cardiac rehabilitation, exercise testing & prescription, cardiovascular skeletal muscle function, cardiac transplantation. 20042007 $49,000 $147,000 II Hill, Michael D University of Calgary Tissue window in stroke thrombolysis -2. Stroke thrombolysis, brain imaging, clinical trial. 20062009 $57,000 $57,000 II, IV Jacobs-Kaufman, Susan E University of Alberta Long-term effect of pregnancy on neural control of the cardiovascular system. Pregnancy, parity, sympathetic. 20062009 $49,000 $49,000 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 87 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Jhamandas, Jack H University of Alberta Role of RFamide peptides in central Neuropeptide FF, prolactincardiovascular and neuroendocrine releasing peptide, regulation. hypothalamus, patch clamp, immunocytochemistry. 20042007 $57,000 $171,000 I Jugdutt, Bodh I University of Alberta Vasopeptidase inhibition and AT1 receptor blockade in remodeling after reperfused MI. 20052008 $49,000 $98,000 I, II Kargacin, Gary J University of Calgary Regulation of compensatory ion channels in cardiac and smooth muscle sarcoplasmic reticulum. Sarcoplasmic reticulum, compensatory charge movement, potassium channels, chloride channels. 20062009 $52,000 $52,000 I Kargacin, Margaret E University of Calgary Phospholamban and regulation of SR calcium. Calcium, cardiac, sarcoplasmic reticulum, Ca-ATPase, phospholamban. 20062009 $49,000 $49,000 I Kavanagh, Katherine M University of Calgary The electrophysiological properties Arrhythmias, electrophysioof the myocardial substrate in health logy, cardiac mapping, heart and disease. failure, myocardial substrate. 20042007 $49,000 $147,000 I King, Kathryn M; Ghali, William; Campbell, Tavis ; Verhoef, Marja University of Calgary Making decisions about using chelation therapy. 20062008 $37,400 $37,400 II, III, IV Krukoff, Teresa L University of Alberta Adrenomedullin and regulation of autonomic function. Adrenomedullin, paraventricular nucleus, autonomic, brain, blood pressure, baroreflex, nitric oxide, calcium. 20062009 $52,000 $52,000 I, II Kubes, Paul University of Calgary Role of LSP-1 as a gatekeeper of the blood brain barrier to neutrophils. Adhesion, inflammation, microvasculatures, selectins, integrin. 20062009 $52,000 $52,000 I Lehner, Richard University of Alberta Triacylglycerol synthesis. Triacylglycerol, acyltransferase, obesity, VLDL, atherosclerosis 20042007 $54,000 $159,500 I Light, Peter E University of Alberta Wolff-Parkinson-White syndrome, AMP-activated protein kinase mutations and cardiac excitability. AMPK, Wolff-ParkinsonWhite syndrome, arrhythmias, sodium hannels, patch clamp. 20052008 $31,545 $63,090 I Lopaschuk, Gary D University of Alberta Cardiac lipotoxicity in obesity and diabetes. Obesity, energy metabolism, fatty acids, cardiotoxicity. 20062009 $57,000 $57,000 I Lytton, Jonathan University of Calgary Molecular regulation of SERCA calcium pumps. Molecular biology, calcium signaling, structure-function, ion transport. 20042007 $52,000 $156,000 I MacDonald, Justin A University of Calgary Characterization of CHASM involvement in cGMP-evoked calcium desensitization in vascular smooth muscle. Calcium desensitization, smooth muscle tone, nitric oxide, cGMP-dependent protein kinase, signal transduction. 20042007 $52,000 $156,000 I $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 88 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Mitchell, J Ross R Foothills Hospital Advanced medical image processing and analysis to identify salvageable tissue in acute ischemic stroke. Morrish, Donald W University of Alberta Endothelial progenitor cells in pregnancy and preeclampsia. Murray, Allan G University of Alberta Hospital Nygren, Anders ; Vigmond, Edward J; Leon, L Joshua 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 20042007 $49,000 $147,000 I Preeclampsia, pregnancy, endothelial progenitor cells. 20062009 $49,000 $49,000 I, II Remodelling of endothelial cells-matrix anchors. Endothelium, vascular, cytoskeleton, cell migration. 20062009 $49,000 $49,000 I, II University of Calgary Computational and experimental investigation of the effects of spatial heterogeneity of refractoriness on inducibility and maintenance of atrial fibrillation in the mouse atria. Atrial fibrillation, mouse atrium, computer models, optical mapping, dispersion of refractoriness. 20052007 $49,000 $98,000 I Patel, Kamala D; Colarusso, Giuseppina T University of Calgary Mechanotransduction in early atherosclerosis. Atherosclerosis, mechanotransduction, VCAM-1, shear stress, adhesion. 20042007 $57,000 $171,000 I Poulin, Marc J; Hanly, Patrick JV University of Calgary Regulation of cerebral blood flow in obstructive sleep apnea: role of nitric oxide. Cerebral blood flow, hypoxia and hypercapnia, obstructive sleep apnea, nitric oxide, doppler ultrasound. 20062009 $65,554 $65,554 I, II, III, IV Proctor, Spencer D University of Alberta Mechanisms of trapping apoB48-remnant lipoproteins in arterial tissue by proteoglycans during atherogenesis and insulin-resistance. Atherogenesis, chylomicrons, proteoglycans, insulinresistance, adiponectin. 20062009 $49,000 $49,000 I Saucier, Deborah M. University of Lethbridge Age and environmental effects of hypoxic-ischemic brain damage. Aging, stroke, hypoxiaischemic, enrichment, recovery. 20042007 $58,500 $174,700 I Severson, David L University of Calgary Mechanisms of diabetic cardiomyopathy - cardiac efficiency in hearts from diabetic mice. Cardiac function, diabetes, diabetic cardiomyopathy. 20062009 $49,000 $49,000 I Sheldon, Robert S University of Calgary Statin induced regression of cardiomyopathy trial (SIRCAT). Hypertrophic cardiomyopathy, statins, cardiac MRI, clinical study, arrhythmia. 20062009 $89,260 $89,260 I, II Shimoni, Yakhin University of Calgary Chamber-specific modulation of cardiac potassium currents. Diabetes, potassium currents, autocrine, natriuretic peptides, angiotensin. 20052008 $49,000 $98,000 I Shuaib, Ashfaq ; Wang, Chen Xu University of Alberta The role of endothelial dysfunction in the pathophysiology of cerebrovascular disease. Apoptosis, endothelium, injury, stroke, vascular. 20052008 $86,000 $176,000 I, II Simmonds, Andrew J; Bell, John B University of Alberta Identification of co-factors for the TEF and MEF-2 family of transcription factors required for establishment and maintenance of heart progenitor cell fate. Transcription, genetic disease loci, heart development, drosophila. 20052008 $46,600 $98,600 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 89 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Smith, Francine G University of Calgary The renin-angiotensin system during ontogeny. Angiotensin II, newborn, kidney, blood pressure, perinatal. 20052008 $49,000 $98,000 I Smith, Peter A; Dryden, William F University of Alberta Nicotinic acetylcholine receptors in the cardiovascular system. Hypertension, cigarettes, ganglionic transmission, microvasculature, coronary endothelial cells. 20052008 $49,000 $98,000 I Sykes, Brian D University of Alberta Structure of cardiac troponin in complex with cardiotonic drugs. Structure, troponin C, troponin I, calcium binding, cardiotonic drugs, NMR. 20052008 $57,000 $114,000 I ter Keurs, Henk EDJ University of Calgary The velocity of cardiac muscle shortening. Cardiac muscle, congestive heart failure, excitation contraction coupling, high speed confocal micro, ischemic heart disease, sarcomere mechanics. 20062009 $57,000 $57,000 I Thebaud, Bernard University of Alberta The role of phosphodiesterases and Ca++ sensitive K+ channels in pulmonary vascular abnormalities associated with congenital diaphragmatic hernia. Pulmonary hypertension of the newborn, phosphodiesterase, potassium channels, smooth muscle cell, lung growth, vasoreactivity. 20042007 $34,600 $148,600 I Tse, Amy Me-War University of Alberta Regulation of chemotransduction in Respiration, neuron-glial carotid bodies. interactions, oxygen sensing, secretion, calcium. 20062009 $52,000 $52,000 I Tsuyuki, Ross T; McAlister, Finlay A; Johnson, Jeffrey A; Jones, Charlotte A; King, Kathryn M; McLean, Donna L University of Alberta Improving hypertension management in patients with diabetes in the community. Adherence, hypertension, diabetes, community, management. 20052007 $88,000 $163,000 III, IV Tuor, Ursula University of Calgary Diagnosis and mechanisms of hypoxic-ischemic injury in cerebral white matter. Magnetic resonance imaging, immunohistochemistry, cerebral hypoxia ischemia, white matter injury, hypothermia. 20052008 $49,000 $98,000 I Vance, Jean Eaton University of Alberta Lipoprotein secretion and phosphatidylserine metabolism. Phosphatidylserine, phospholipid, VLDL secretion, apo B, phosphatidylethanolamine. 20042007 $49,000 $147,000 I Vigmond, Edward J; Vinet, Alain University of Calgary Localization of neural modulation of atrial excitation and repolarization and the arrhythmogenic consequences. Electrograms, atria, cardiac autonomic nervous system, arrhythmogenesis, computer modeling. 20062009 $45,200 $45,200 I $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 90 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Walsh, Michael P University of Calgary Vascular smooth muscle S100A11 calcium-binding protein. Vascular smooth muscle, S100 calcium-binding proteins, contractility, membrane-cytoskeleton interaction, annexins. 20042007 $57,000 $171,000 I Welsh, Donald G; Vigmond, Edward J University of Calgary Cell-to-cell communication in the resistance vasculature. Peripheral circulation, computer modeling, electrophysiology, vascular smooth muscle, cell-to-cell communication. 20042007 $49,000 $147,000 I Winston, Brent W University of Calgary Induction of factor B and/or activation of the alternative complement cascade contribute to 20052008 $52,000 $104,000 I, II 20042007 $57,000 $171,000 I $ cumulatif reçu en 2007 cardiac dysfunction, multiple organ dysfunction and shock in sepsis. Wong, Norman CW University of Calgary Augmenting apolipoprotein AI expression: effects on reverse cholesterol transport and atherosclerosis. Young, Howard S University of Alberta Molecular insights into heart disease - structure, function and regulation of SERCA2a. Heart disease, muscle, membrane, regulation, sarcoplasmic reticulum. 20062009 $57,000 $57,000 I Zamponi, Gerald W University of Calgary Regulation of calcium channel beta subunit function by Rem2. Calcium channels, Rem2, immunocytochemistry, electophysiology, imaging. 20052008 $57,000 $114,000 I 06-07 $ Cumulative $ Theme to 2007 Thème Saskatchewan | Saskatchewan Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Hiebert, Linda M University of Saskatchewan Oral heparins. Lee, Paul M; Prasad, Kailash University of Saskatchewan Hyperhomocysteinemia and hypertension. Meng, Qing H; Wu, Lingyun; Wang, Rui University of Saskatchewan Protective role of hydrogen sulfide in atherosclerosis. Ndisang, Joseph Fomusi University of Saskatchewan Interaction of the heme oxygenase pathway with renin-angiotensin system in diabetes. Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale $ cumulatif reçu en 2007 II: Clinical II : Clinique Heparin, oral absorption, endothelium, thrombosis models, pharmacokinetics. 20052008 $58,500 $118,500 I 20042007 $40,000 $141,000 I Cystathionine gamma-lyase (CSE), hydrogen sulfide (H2S), homocyteine, balloon injury, atherosclerosis. 20052008 $58,500 $118,500 I Diabetes, hypertension, angiotensin, heme oxygenase inducers, carbon monoxide. 20062009 $58,500 $58,500 I, II, III, IV III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 91 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Paterson, Phyllis G University of Saskatchewan Protein-energy malnutrition as a determinant of brain injury in stroke. Nutrition, stroke, glutathione, protein-energy malnutrition, global ischemia. 20042007 $58,500 $88,328 I Prasad, Kailash University of Saskatchewan Flax lignan complex in the progression and regression of hypercholesterolemic atherosclerosis and mechanisms. Atherosclerosis, endothelial cell function, lipids, oxygen radicals, regression. 20062009 $58,500 $58,500 I Sharma, Rajendra K University of Saskatchewan Calmodulin regulated systems in heart. Ca2+, calmodulin, calmodulinbinding proteins, Ca2+ activated proteases, phosphodiesterases, cardiac metabolism. 20062009 $67,000 $67,000 I Walz, Wolfgang University of Saskatchewan The gliotic response in focal ischemia. Astrocytes, reactive gliosis, focal ischemia, patch clamp, immunocytochemistry. 20052008 $58,500 $118,500 I Wu, Lingyun University of Saskatchewan Methylglyoxal, a causative factor for hypertension development - MG induced vascular damage and the underlying mechanisms. Methylglyoxal, advanced glycated endproducts (AGEs), vascular function, proliferation, hypertension. 20052008 $65,000 $140,000 I Zhang, Xia University of Saskatchewan Post stroke treatment with cannabinoids for promoting neural regeration. Ischemia, marijuana, neurogenesis, hippocampus, functional recovery. 20062009 $58,500 $58,500 I $ cumulatif reçu en 2007 Manitoba | Manitoba 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Bose, Ratna University of Manitoba Characterization of the sodium/ calcium exchanger in human platelets and its role in diabetes. Platelets, calcium, sodium, diabetes. 20062009 $35,000 $35,000 I, II Czubryt, Michael P St. Boniface G.H. Research Centre The role of scleraxis in the regulation of cardiac collagen synthesis. Fibrosis, myofibroblasts, gene expression, collagen, transciption. 20062009 $33,000 $33,000 I Del Bigio, Marc R University of Manitoba Periventricular hemorrhage in immature brain. Stroke, cerebral palsy, perinatal, brain hemorrhage. 20062009 $39,000 $39,000 I Dhalla, Naranjan S St. Boniface G.H. Research Centre Studies on the biochemical basis of heart function: adrenergic mechanisms in failing hearts. Congestive heart failure, beta-adrenoceptors, G-proteins, adenylyl cyclase, signal transduction. 20042007 $50,500 $151,000 I Dixon, Ian St. Boniface G.H. Research Centre Inhibition of the Smad signal in post-MI heart failure. Myocardial infarction, gene expression, cardiac fibrosis, collagen, hypertrophy and heart failure, Smad. 20042007 $45,300 $127,400 I Hatch, Grant M University of Manitoba Regulation of cardiolipin biosynthesis. Heart, cardiolipin, phospholipid, metabolism, eukaryotic cells. 20042007 $35,000 $98,000 I $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 92 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Israels, Sarah J Manitoba Institute of Cell Biology The roles of CD63 and PI 4-kinase in platelet integrin signaling. Jones, Peter JH University of Manitoba Satiety and energy expenditure enhancement actions of diacylglycerol oil. Kardami, Elissavet University of Manitoba Connexin43 and cardiac myocyte proliferation. Kirshenbaum, Lorrie A St. Boniface G.H. Research Centre Mechanisms of p53 mediated apoptosis in the heart. Light, Robert B; Jacobs, Hans K St. Boniface G.H. Research Centre Left ventricular performance in gram negative sepsis. McNicol, Archibald University of Manitoba Mesaeli, Nasrin Moghadasian, Mohammed Hassan 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 20052007 $40,000 $75,000 I Diacylglycerol oil, obesity, weight loss, satiety, magnetic resonance imaging. 20062009 $34,000 $34,000 I, II, III, IV Connexin43, cardiomyocytes, cell cycle inhibition, structurefunction, heart regeneration. 20052008 $50,600 $96,200 I 20042007 $47,400 $125,200 I Myocardial depression in sepsis, septic shock, myocardial depressant factor. 20042007 $44,400 $122,200 I MAP kinase pathways and platelets. Platelets, signaling, kinases, GEMs. 20052008 $38,000 $73,000 I St. Boniface G.H. Research Centre Regulation of cell proliferation by calreticulin. Vascular function, calcium regulation, gene regulation. 20062009 $38,000 $38,000 I University of Manitoba Heart transplantation, apo Mechanisms of atherogenesis in apolipoprotein E-KO mice: studies E-KO mice, lipoprotein, of the role of plasma lipoproteins, probucol, atherosclerosis. vascular apolipoprotein E, dietary cholesterol and probucol in a mouse heart transplant model. 20052008 $39,000 $77,000 I Netticadan, Thomas St. Boniface G.H. J Research Centre Mechanisms underlying contractile dysfunction in heart failure due to volume overload. Sarcoplasmic reticulum, volume overload hypertrophy, heart failure. 20042007 $33,000 $94,000 I O, Karmin St. Boniface G.H. Research Centre Effect of folic acid on hyperhomocysteinemia. Hyperhomocysteinemia, atherosclerosis, folic acid, chemokines, oxidative stress. 20062009 $36,000 $36,000 I Pierce, Grant N St. Boniface G.H. Research Centre Involvement of Na/Ca exchange in Heart, Na/Ca exchange, ischemia/reperfusion (I/R) injury. cardiomyocytes, adenovirus. 20042007 $48,500 $48,500 I Schlichter, Lyanne C; Peeling, James ; Corbett, Dale R Toronto Western Research Institute Targeting K channels to control inflammation in stroke. Intracerebral hemorrhage, focal ischemia, retinal ischemia, optic nerve transection, potassium channels, CNS inflammation, immune-cell activation. 20052008 $49,000 $92,000 I University of Manitoba Regulation by stress-associated scaffold protein in ischemia/ reperfusion. SAP kinase, scaffold, regulation, ischemia/ reperfusion, inhibitor. 20062009 $32,000 $32,000 I Wigle, Jeffrey TN St. Boniface G.H. Research Centre Mox mediated differentiation of vascular smooth muscle cells and cardiomyocytes in embryonic development and disease. Cell-cycle, atherosclerosis, homeobox, differentiation, migration. 20042007 $37,000 $100,000 I Zhang, Shetuan University of Manitoba Molecular mechanisms of drug-induced long QT syndrome and sudden cardiac death. Myocardium, emergency cardiac care, electrophysiology, molecular biological techniques, cardiac dysrrhythmias. 20062009 $36,000 $36,000 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 93 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Ontario | Ontario Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Adams, Michael A; Heaton, Jeremy PW Queen’s University Antihypertensive treatment strategies in the management of sexual dysfunction. Hypertension, blood pressure, sexual dysfunction, antihypertensives, vascular structure, endothelial function. 20052008 $99,010 $330,003 I Adeli, Khosrow Hospital for Sick Children Molecular mechanisms of apolipoprotein B degradation. Apolipoprotein B, degradation, hepatocytes, proteasome, ER60. 20052009 $113,285 $457,758 I Adeli, Khosrow Hospital for Sick Children Molecular mechanisms of VLDL overproduction in insulin resistant states. Apolipoprotein B, lipoprotein, liver, insulin resistance, hamster, insulin signaling, diabetes. 20042007 $100,798 $296,503 I Anand, Sonia S; Bosch, Jacqueline J; Gaudet, Daniel; Gerstein, Hertzel C; Keavney, Bernard D; Merchant, Anwar T; Pogue, Janice M; Yusuf, Salim McMaster University EpiDREAM - A prospective cohort study to determine environmental and genetic determinants of metabolic syndrome related factors. Metabolic syndrome, cohort study, gene-environment interactions. 20062009 $165,072 $475,656 IV Ananthanarayanan, Vettai S McMaster University Structural aspects of collagen biosynthesis: studies on Hsp47. Collagen, Hsp47, structurefunction correlation, protein structure, spectroscopy. 20042007 $67,741 $199,369 I Andrew, R David Queen’s University Imaging and preventing early stroke damage in intact mammalian neurons. 2-photon, anoxic depolarization, dendrite, swelling, imaging. 20062009 $72,613 $220,406 I, II Austin, Richard C; Chan, Anthony McMaster University Inhibition of tissue factor procoagulant activity by GRP78 and its role in atherothrombotic disease. GRP78, tissue factor, thrombin generation, endoplasmic reticulum stress, thromboembolic disease. 20042007 $81,737 $240,981 I Backx, Peter H University of Toronto Role of inward rectifier K+ and HCN channels in heart. Transgenics, electrophysiology, heart disease, ion channels, arrhythmias. 20052008 $126,393 $379,259 I Ball, Eric H University of Western Ontario Metavinculin interactions in hereditary cardiomyopathy. Intercalated disc, protein interactions, protein structure, adherens junction, cytoskeleton. 20052007 $61,853 $123,706 I Bartha, Robert; Lee, Ting-Yim; Xenocostas, Anargyros Robarts Research Institute New metabolic imaging approaches to assess brain tissue viability. 1H MRS, high resolution metabolic MR imaging, acute cerebral ischemia, metabolite quantification, molecular penumbra. 20062009 $81,134 $251,519 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 94 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Bates, Shannon M; Ginsberg, Jeffrey S; Kearon, Clive; Julian, Jim A; Douketis, James D McMaster University Diagnosis of suspected pulmonary embolism with D-dimer. Pulmonary embolism, diagnosis, D-dimer. 20052007 $66,591 $181,578 II Beanlands, Rob SB; Haddad, Haissam; Burwash, Ian G; Floras, John S; DaSilva, Jean N; de Kemp, Robert A; Leech, Judith A University of Ottawa Heart Institute Effects of continuous positive airway pressure therapy on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea. Heart failure, sleep apnea, oxidative metabolism, cardiac efficiency, sympathetic nerve function, PEP. 20052008 $120,972 $362,941 II Benazon, Nili R; Arthur, Heather M; Kodis, Jennifer; Toner, Brenda B; Blanchard, Chris M Centre for Addiction and Mental Health Correlates of women’s compliance with exercise prescriptions during and following cardiac rehabilitation. Cardiology, health-related behaviours, exercise, women, psychosocial. 20052007 $54,109 $106,805 II Bendeck, Michelle P University of Toronto The effect of doxycycline on smooth muscle cell response to injury. Vascular biology, atherosclerosis/restenosis, matrix metalloproteinase, extracellular matrix. 20042007 $69,370 $204,114 I Boffa, Michael B Queen’s University The TAFI pathway in thrombolysis: regulation of TAFI activation and role of the platelet pool of TAFI. TAFI, fibrinolysis, thrombolysis, platelets, transgenic mice. 20062009 $86,839 $289,600 I Bonen, Arend University of Guelph Regulation of fatty acid transport in the heart. Fatty acid transporters, transport, metabolism, heart, cardiac myocytes. 20062011 $96,323 $488,296 I Boughner, Derek R; Rogers, Kem A; Rutt, Brian K; Drangova, Maria University of Western Ontario Aortic sclerosis in an animal model: progression, regression and evaluation. 20052007 $73,539 $150,689 I, II Boughner, Derek R; Rogers, Kem A; Lacfield, James University of Western Ontario A tissue engineering approach to bioprosthetic heart valve design. Tissue engineering, aortic valve, biomechanics, ultrasound imaging, valvular interstitial cells. 20062009 $107,038 $307,457 I Brouwer, Brenda; Malouin, Francine; Bagg, Stephen Queen’s University Does mental practice promote corticol reorganization and improved hand function in acute stroke? A prospective intervention study. Rehabilitation, stroke, transcranial magnetic stimulation, imagery, function. 20042007 $45,842 $152,831 I, II Brown, Arthur Robarts Research Institute EphA3 receptor signaling in heart development. Heart development, Eph receptors, mouse genetics, knock-outs, cell signaling. 20022007 $101,478 $488,236 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 95 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Bruneau, Benoit G Hospital for Sick Children Roles of T-box genes in cardiovascular research. Transgenic mice, congenital heart defects, transcription factors, gene expression, cardiovascular development. 20042007 $100,248 $300,744 I Capone, John P; Rachubinski, Richard A McMaster University Function and mechanisms of action of peroxisome proliferator-activated receptors. Nuclear hormone receptors, peroxisome proliferators, gene expression, transcription factors, lipid metabolism. 20032008 $145,042 $716,322 I Cepinskas, Gediminas Lawson Research Institute The mechanisms of neutrophilinduced negative feedback regulation of transcription factor NFkB in endothelial cells during inflammation: role of PECAM-1 (CD31). Inflammation/sepsis, adhesion molecules, cell signaling, endothelium, leukocytes. 20052007 $49,540 $99,080 I Chakrabarti, Subrata; Karmazyn, Morris University of Western Ontario Vasoactive and cardioactive factors in diabetic heart disease. Cardiomyopathy, diabetes, hypertrophy, gene transcription, PARP. 20062008 $75,550 $148,684 I Chan, Anthony KC McMaster University Investigation into the interactions of covalent antithrombin-heparin (ATH) complex with surface-bound coagulant factors. Antithrombin, heparin, anticoagulant, fibrin, endothelial. 20042007 $72,690 $213,824 I Chan, Anthony KC McMaster University The influence of age on the protein C pathway during chemotherapy treatment. Children, thromboembolism, (anti)coagulation, protein C, chemotherapy. 20052007 $83,582 $162,716 I Chan, Christopher T; Verma, Subodh Toronto General Hospital Impact of uremia on endothelial progenitor cells. Renal failure, endothelial function, arterial compliance, left ventricular hypertrophy, endothelial progenitor cells. 20052007 $67,905 $134,842 I, II Chauhan, Vijay S; Picton, Peter Toronto General Hospital Characterizing ventricular repolarization alternans in human cardiomyopathy. Repolarization, tachyarrhythmia, cardiomyopathy, ventricle, human. 20062007 $35,000 $35,000 II Choong, Karen; Bohn, Desmond; Hutchison, James; Menon, Kusum; Gaboury, Isabelle McMaster University A study of the efficacy of vasopressin in pediatric vasodilatory shock. Vasodilatory shock, vasopressin, pediatrics, clinical trial. 20062007 $61,623 $61,623 II Ciriello, John University of Western Ontario Role of sex steroids in central regulation of arterial pressure. Ventral medulla, aterial pressure, vagus, hypertension, female, Gaba, nitric oxide. 20062007 $35,000 $35,000 I Clarke, Bryan J McMaster Factor VII as an inhibitor of coagulation, sepsis and cancer. Coagulation, clotting factor VII, tissue factor, thrombosis, coagulation inhibitors. 20062008 $82,723 $167,101 I University *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 96 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Coles, John G; Hannigan, Gregory E Hospital for Sick Children Integrin-linked kinase (ILK) induces adaptive remodeling in dilated cardiac failure. Cardiac hypertrophy, signal transduction, transgenesis, heart failure, congenital heart disease. 20052007 $86,440 $171,975 I, II Coles, John G; Hannigan, Gregory E Hospital for Sick Children The regulation of cellular signaling in cardiac progenitor cells. Cardiac stem cells, cardiomyogenesis, cell signaling, cardiac surgery, regenerative medicine. 20062008 $76,039 $153,599 I Connelly, Philip W St. Michael’s Hospital Comparative studies of paraoxonase 1 and paraoxonase 3. Lactones, paraoxonase, lipoproteins, atherosclerosis, hydroxy fatty acids. 20052008 $59,826 $179,501 I Connelly, Philip W; Stewart, Duncan J St. Michael’s Hospital Molecular mechanisms for oxidation of high density lipoproteins. Nitric oxide, high density lipoproteins, inflammation, oxidation, vascular. 20062008 $96,529 $195,994 I, II Copeland, John W University of Ottawa Role of formin proteins in shear stress-induced cytoskeletal remodeling in endothelial cells. Actin cytoskeleton, shear stress, atherosclerosis, formin, adherens junctions. 20062008 $87,865 $165,875 I Cote, Graham P Queen’s University Formation of podosome-like structures in vascular smooth muscle cell by PAK. Smooth muscle cell, biochemistry. 20042007 $79,353 $233,678 I Courtman, David W; Stewart, Duncan J St. Michael’s Hospital Arterial remodeling: regulation of aneurysm growth. Aneurysm, extracellular matrix, smooth muscle, angiotensin, transcription factor. 20052007 $69,360 $137,360 I Cregan, Sean P Robarts Research Institute p53 signaling in oxidative damage induced neuronal apoptosis. Stroke, p53, apoptosis, oxidative damage, neuronal injury. 20062008 $72,800 $147,056 I Crowther, Mark A; Lim, Wendy; Clase, Catherine M; Douketis, James D; Rabbat, Christian G St. Joseph’s Hospital Tinzaparin for treatment of venous thromboembolism in renal insufficiency: a pilot study. Low molecular weight heparin, tinzaparin, renal insufficiency, venous thromboembolism, safety. 20052007 $57,893 $116,486 II Cybulsky, Myron I University of Toronto Endothelial cell NF-kappaB signal transduction in atherosclerosis. NF-kB, endothelium, atherosclerosis, hemodynamics, transgenic mice. 20032007 $101,501 $394,220 I Cybulsky, Myron I University of Toronto Leukocyte recruitment to atherosclerosis lesions. Atherosclerosis, monocytes, recruitment, survival, adhesion molecules, M-CSF (CSF1) 20042007 $109,230 $321,482 I Danckert, James A University of Waterloo Examining the behavioural and neural effects of prism adaptation in stroke patients suffering from unilateral neglect. Neglect, prism adaptation, rehabilitation, fMRI. 20062008 $42,550 $85,100 II Drangova, Maria; Pickering, J Geoffrey Robarts Research Institute Optimized micro-CT of the mouse heart and coronary vasculature. Three-dimensional micro computed tomography, murine coronary artery imaging, vascular biology, murine models of atherosclerosis, angiogenesis. 20052007 $65,053 $131,188 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 97 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Dumont, Daniel J Sunnybrook Health Sciences Centre Molecular studies examing the role of lymphangiogenic signaling in heart disease. Lymphangiogenesis, signal transduction, proteomics, transgenic animals. 20042007 $74,000 $222,000 I Duncan, Alison; Capes, Sarah E; Darlington, Gerarda A University of Guelph Effect of soy protein on glycemic control and serum lipids in people with type 2 diabetes. Soy protein, type 2 diabetes, serum lipids, glycemic control, cardiovascular disease. 20052007 $56,890 $100,290 I, II Eikelboom, John WA; Anand, Sonia S; Ginsberg, Jeffrey S; Weitz, Jeffrey I; Tran, Huyen AM Hamilton General Hospital Determining the mechanisms of aspirin resistance. Aspirin, resistance, cardiovascular disease, Thromboxane, Rofecoxib. 20052007 $122,900 $242,720 II Ellis, Christopher G University of Western Ontario Local regulation of microvasculature oxygen exchange. Oxygen sensor, erythrocyte, oxygen saturation, oxygen gradient, regulation. 20052007 $68,384 $138,983 I Eubanks, James H Toronto Western Research Institute Methyl DNA-binding factor complexes and neurodegeneration. Neuroprotection, methyl DNAbinding factor, epigenetics, cell biology, mouse model. 20062009 $83,929 $255,036 I Fehlings, Michael G; Velumian, Alexander A Toronto Western Research Institute The ischemic axon: cross-talk with myelin in K+ channel terms. Myelinated axons, oligodendrocytes, glutamate receptors, K+ channels, conduction block. 20062008 $79,089 $158,178 I Feindel, Christopher M; Borger, Michael A; Green, Robin EA; Djaiani, George N; Ivanov, Joan Toronto General Hospital Minimal invasive cardiac surgery: is it safe for the brain? Cardiopulmonary bypass, neuropsychological impairment, cerebral emboli, transcranial Doppler, cardiac surgery. 20052007 $92,499 $210,998 II Feindel, Christopher M; Vivek, Rao University Health Network Erythropoietin and hypertonic saline for cardiac transplant. Cardiac transplant, myocardial function, cytokine, hypertonic saline, erythropoietin. 20062009 $92,959 $276,248 I Feng, Qingping London Health Sciences Centre Neuronal nitric oxide synthase and heart failure. Neuronal nitric oxide synthase, apoptosis, hypertrophy, myocardial infarction, heart failure. 20042007 $66,692 $196,180 I Feng, Zhong-Ping University of Toronto Modulatory mechansisms underlying expression of cardiac voltage-dependent calcium channels. Calcium channel density, surface expression, gene expression, endocytosis, protein kinases, cardiac myocytes. 20062009 $62,250 $186,750 I Ferguson, Alastair V Queen’s University Orexinergic pathways in central autonomic control. Central autonomic control, peptides, electrophysiology, cardiovascular regulation, neuroscience. 20022007 $90,736 $456,383 I Ferguson, Stephen SG Robarts Research Institute Regulation of G proteincoupled receptor signaling desensitization and esensitization. Small G proteins, angiotensin, beta-adrenergic receptor, desensitization, resensitization, protein kinases. 20062011 $119,696 $615,378 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 98 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Finestone, Hillel M; Marshall, Shawn C; O’Rourke, Keith FP; Blair, Richard S Elizabeth Bruyère Health Centre Driving post-stroke: a prospective study of community integration and driving habits. Driving, stroke, community integration, quality of life. 20052007 $67,618 $134,706 III, IV Floras, John S Mount Sinai Hospital Cardiovascular regulation in men and women with heart failure and hypertension. Sympathetic nervous system, heart failure, hypertension, humans, estrogen. 20022007 $110,777 $535,708 II Fremes, Stephen E; Cohen, Eric A; Desai, Nimesh D Sunnybrook Health Sciences Centre Graft imaging to improve patency (GRIIP) study. Coronary bypass surgery, intraoperative imaging, clinical trials, angiography, ultrasound. 20052007 $99,851 $199,702 II Fremes, Stephen E; Tu, Jack V; Anderson, Geoffrey M; Novick, Richard J; Guru, Veena; Rubens, Fraser D; Mazer, David; Adhikari, Neill KJ; Scales, Damon C; Fowler, Robert A; Feindel, Christopher M Institute for Clinical Evaluative Sciences-Toronto Unraveling the black box of adverse events in cardiac surgery. Adverse events, patient safety, cardiac surgery, quality of care, independent audit, best evidence, best practices, safety culture. 20062009 $90,350 $260,950 II, III Funk, Colin D Queen’s University COX-2 pathway and cardiovascular disease. 20062009 $116,208 $353,501 I Gagnon, France; Wells, Philip S; Bulman, Dennis E University of Ottawa Genome-wide search for oligogenes in factor V Leiden thrombophilia. Thrombosis, genetic epidemiology, quantitative traits, thrombophilia. 20052008 $55,537 $166,611 I, II Gaisano, Herbert Y University of Toronto SNARE regulation of cardiac sulfonylurea receptor, a novel drug target for cardiac ischemia. ATP-sensitive potassium channels, SNARE proteins, electrophysiology, cardiac myocytes, protein interactions. 20052007 $73,848 $146,791 I Gao, Yu-Jing; Sharma, Arya M; Lee, Robert MKW McMaster University Perivascular adiposes tissue, reactive oxygen species, and hypertension. Adipocytes, blood vessels, contraction, hypertension, morphology, reactive oxygen species. 20062007 $35,000 $35,000 I Garland, S Jayne University of Western Ontario Standing balance following stroke: a novel approach for postural muscle retraining. Balance, stroke, electromyography, posturography, rehabilitation. 20052008 $58,215 $175,585 I, II Giacca, Adria; Fantus, Ivan G University of Toronto Anti-atherogenic effect of insulin in vivo. Hyperinsulinemia, insulin resistance, restenosis, Apo Enull mouse, atherosclerosis. 20052008 $62,537 $161,456 I, II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 99 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Goldfield, Gary S; McGrath, Patrick; Watters, Carolyn R; Prud’homme, Denis DP; Hadjiyannakis, Stasia; Sigal, Ronald J; Gougeon, Rèjeanne; Jadad, Alejandro Children’s Hospital of Eastern Ontario Family-based behavioural treatment for childhood obesity delivered via internet: a randomized controlled trial. Obesity, children, family-based, internet, behaviour therapy. 20052007 $49,835 $99,835 II, III Gollob, Michael H; Roberts, Robert; Beanlands, Rob S; de Kemp, Robert A; Stewart, Alexandre FR University of Ottawa Heart Institute Pathophysiologic study of the role of AMPK in cardiac arrhythmias, conduction system development, and metabolic cardiomyopathy. Arrhythmia, cardiomyopathy, electrophysiology. 20062009 $79,175 $237,047 I, II Gollob, Michael H; Roberts, Robert; Wells, George; Tang, Anthony University of Ottawa Heart Institute Genetic predictors of ventricular arrhythmias in patients with heart failure. Genetics, arrhythmias, heart failure. 20062008 $50,320 $101,850 I, II, III Goodman, Jack M; Sasson, Zion University of Toronto Effects of prolonged strenuous exercise on left ventricular function. Exercise, left ventricle, contractility, echocardiography. 20062008 $42,490 $83,090 I, II Graham, Charles H Queen’s University Mechanisms regulating the development and pathophysiology of pre-eclamptic hypertension. Hypertension, pre-eclampsia, pregnancy, hypoxia, nitric oxide. 20052007 $91,665 $181,606 I Graham, Simon J; Black, Sandra E; McIlroy, William E; Staines, W Richard Sunnybrook Health Sciences Centre Virtual reality for stroke recovery: initial fMRI studies. fMRI, stroke recovery, virtual reality, sensorimotor systems, simulation. 20052007 $47,080 $95,660 I, II Gramolini, Anthony University of Toronto Molecular basis of PLN regulation and function in cardiac muscle. Phospholamban, calcium, cardiac muscle, sarcoplasmic reticulum, dilated cardiomyopathy. 20062008 $98,729 $197,404 I, II Grant, David R; Levy, Gary; Gorczynski, Reginald M; Phillips, James M; Adamson, S Lee Toronto General Hospital Role of fgl2 in transplantation and cardiac development. Thrombosis, transplantation, macrophage, endothelial cells, fibrin. 20052008 $81,655 $234,358 I Grinstein, Sergio; Trimble, William S Hospital for Sick Children Dual role of CD36 in macrophages: atherosclerosis and immune responsiveness. Macrophage, CD36, receptor, signal transduction, endocytosis. 20062010 $80,951 $343,878 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 100 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Gross, Gil J Hospital for Sick Children Ventricular repolarization in complete heart block. Complete heart block, cardiac pacing, repolarizing currents, ventricular electrical remodeling, autonomic regulation. 20042007 $70,849 $208,406 I Gross, Gil J; Redington, Andrew N Hospital for Sick Children Contractile and electrophysiologic adaptations to constrained heart rate conditions. Tachycardia, bradycardia, remodeling, repolarization, force-frequency relationship. 20062008 $103,631 $209,097 I Grover, Ashok K McMaster University Caloxins: novel inhibitors of plasma membrane calcium pumps. Calcium pumps, phage display, drug discovery, cardiovascular. 20062008 $74,608 $150,708 I Grover, Ashok K McMaster University Receptor stimulated ascorbate release from endothelial cells. Vitamin C, endothelium, coronary artery, shear stress, oxidative stress. 20042007 $84,701 $249,154 I Gruenwald, Colleen; Chan, Anthony KC; Holtby, Helen M; McCrindle, Brian W; Van Arsdell, Glen S Hospital for Sick Children Individualized heparin and protamine management in infants undergoing cardiopulmonary bypass for cardiac surgery reduces bleeding and blood transfusion requirements. Coagulation, infants, cardiopulmonary bypass (CPB), heparin, bleeding. 20062008 $57,063 $108,566 II Gupta, Radhey S McMaster University Studies on adenosine kinase inhibitors and its gene regulation. Adenosine kinase, enzyme inhibitors, structure-activity studies, bisphosphonates, gene regulation, high throughput-screening. 20042007 $85,343 $243,979 I Haché, Robert JG Ottawa Health Research Institute Regulation of human primary preadipocyte differentiation by glucocorticoids. Metabolic disease, obesity, glucocorticoid hormone action, preadipocyte differentiation, control of white fat deposition. 20062009 $90,138 $275,858 I Hammond, James R University of Western Ontario Role of nucleoside transporters in the regulation of the vascular effects of adenosine and its metabolites. Transporters, endothelium, adenosine, oxidative-stress, preconditioning. 20052008 $70,846 $212,566 I Hatton, Mark WC; Clarke, Bryan J McMaster University Comparative study of the procoagulant and pro-fibrinolytic nature of VX-2 tumours and their effusions when located in different body compartments. Tumour growth, malignant effusion, hemostasis factors, platelets, angiogenesis, anti-angiogenesis. 20052008 $70,435 $211,355 I Hayward, Catherine PM McMaster University Structure-function analysis of multimerin 1 proadhesive function. Platelet adhesion, vascular adhesion, leukocyte adhesion, aggregation, multimerin 1. 20062009 $137,397 $322,071 I Hayward, Catherine PM McMaster University Studies of the mechanisms involved in generating profibrinolytic and antifibrinolytic human platelets. Platelets, fibrinolysis, stroke, Quebec Platelet Disorder, urokinase-type plasminogen activator. 20062009 $80,462 $244,132 I, II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 101 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Hegele, Robert A Robarts Research Institute The phenomics of atherosclerosis in monogenic insulin resistance syndrome. Atherosclerosis biomarkers, DNA analysis, magnetic resonance imaging, ultrasound imaging, insulin resistance syndrome. 20042007 $65,518 $251,302 I Heximer, Scott P University of Toronto Defining the role of RGS2 as a mediator of vascular signaling and blood pressure regulation. RGS protein, heterotrimeric G-protein signaling, hypertension, vascular smooth muscle cell, cyclic nucleotide-mediated vasodilation. 20062009 $105,639 $322,874 I Hinek, Aleksander Hospital for Sick Children Elastin as a crucial factor modulating cellular proliferation - relevance to arterial diseases. 20032008 $95,932 $471,977 I Holbrook, Anne M; Pereira, Jennifer A; Thabane, Lehana; van Walraven, Carl St. Joseph’s Hospital Validation and implementation of individualized benefit: harm profiles for opitmal warfarin prescribing. Stroke, bleeding, predictor, benefit:harm analysis, warfarin. 20062008 $9,125 $16,000 II, IV Holdsworth, David W; Rankin, Richard N Robarts Research Institute Investigation of flow in the stenosed carotid bifurcation. Stroke, carotid bifurcation disease, Doppler ultrasound, hemodynamics, artery-to-artery embolization. 20032008 $87,104 $422,100 I Hou, Sheng T National Research Council of Canada (Ottawa) Semaphorin-3a’s role in axonal degeneration and regeneration following cerebral ischemia. Semaphorin, neuropilin, axon, regeneration, stroke. 20062009 $59,154 $189,274 I Hough, Margaret R; Dick, Alexander J Sunnybrook Health Sciences Centre Cardiac repair and regeneration. Embryonic stem cells, in vivo differentiation, cardiomyocytes, cardiac regeneration. 20062009 $84,613 $263,519 I Huff, Murray W Robarts Research Institute Regulation of ApoB metabolism: relationship to atherosclerosis. 20052010 $133,543 $679,770 I Husain, Mansoor; Drucker, Daniel J Toronto General Hospital Role of glucagon-like peptides in cardiac health and disease. Glucagon peptides & receptors, myocardial infarction, heart failure, transgenic mice, knockout mice. 20062009 $139,000 $371,349 I Igdoura, Suleiman A; Trigatti, Bernardo L McMaster University Sialidase (neu1) as a novel risk factor for cardiovascular disease. Lipoproteins, atherosclerosis, macrophage, sialylation, apoE, LDL. 20062008 $74,175 $157,381 I Ikura, Mitsuhiko Princess Margaret Hospital Structural elucidation of intracellular calcium transporters. Ca2+ transport, structural biology, endoplasmic reticulum, molecular recognition, inositol 20062011 $99,575 $511,985 I phosphate. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 102 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Irvine, Marilyn Jane; Stanley, Jill; Dorian, Paul; Ritvo, Paul G; Harris, Louise; Newman, David M; Sears, Samuel F; Cribbie, Robert York University Psychological support for implantable defibrillator patients. 20062008 $91,244 $122,867 II, III Jaeggi, Edgar T; Kingdom, John CP; Keating, Sarah J; Bradley, Timothy J Hospital for Sick Children Intrauterine growth restriction with early and late onset placental insufficiency: impact on myocardial function and arterial compliance. 20062008 $38,260 $77,255 I, II Janssen, Luke J McMaster University Unidentified endothelium-derived signalling molecules are isoprostanes. 20042007 $51,368 $154,104 I Kanji, Salmaan; Hèbert, Paul C; Fergusson, Dean; Tang, Anthony SL; McIntyre, Lauralyn A; Dodek, Peter M; Albert, Martin; Turgeon, Alexis F; Pagliarello, Giuseppe; Marshall, John C Ottawa Hospital General Campus Atrial fibrillation in the intensive Pilot study, atrial fibrillation, care unit: a randomized conantiarrhythmic therapy, trolled trial (Afib ICU study). intensive care unit, beta adrenergic blockage, electrical cardioversion. 20062007 $81,116 $81,116 II Karmazyn, Morris University of Western Ontario Modulation of cardiomyocyte hypertrophy by nitric oxide and endothelin-1 in the aging myocardium. Nitric oxide, endothelin, cardiac hypertrophy, heart failure, aging, gender. 20052009 $97,637 $395,505 I Kawaja, Michael D Queen’s University Sympathetic hyperinnervation associated with the hypertensive phenotype of rats and mice. Hypertension, sympathetic, mesenteric arteries, neurotrophin, transgenic. 20052008 $71,002 $218,397 I Kearon, Clive; Bates, Shannon M; Linkins, Lori-Ann; Julian, James A; Ginsberg, Jeffrey S; Kahn, Susan R; Douketis, James D Hamilton Civic Hospital Research Centre Selective D-dimer testing for diagnosis of deep vein thrombosis. 20042007 $121,935 $359,515 II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Vascular smooth muscle, endothelium, ion channels, intracellular signalling, hypertension. III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 103 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Kearon, Clive; Ginsberg, Jeffrey S; Julian, Jim A; Kahn, Susan R; Wells, Philip S; Douketis, James D McMaster University Thrombosis in family members of patients with unprovoked venous thromboembolism. Venous thrombosis, thrombophilia, clinical management, screening, counselling. 20052007 $68,985 $136,139 I, II, III, IV Keeley, Fred W Hospital for Sick Children Recombinantly expressed polypeptides of human elastin as a novel tool for investigations of the structure, self-assembly and properties of elastin-like materials. Elastin, elastic tissue, blood vessels, extracellular matrix, biomaterial 20042009 $111,517 $557,707 I Kelton, John G; Moore, Jane C; Begbie, Megan E McMaster University Platelet-mediated acute thrombotic disorders. Platelets, immune, thrombocytopenia, heparin, thormbosis. 20052010 $141,157 $726,784 I, II Khokha, Rama Ontario Cancer Institute Molecular dissection of the distinct functions of TIMP-3 and TIMP-4 in heart disease. TIMP deficiency, metalloproteinase, cytokines, ECM, heart disease. 20062009 $75,861 $227,583 I Koschinsky, Marlys L Queen’s University Interactions of Lp(a) with the plasminogen system: mechanisms and pathophysiological consequences. Lipoprotein(a), apoliprotein(a), plasminogen, thrombosis, atherosclerosis. 20052010 $98,050 $493,817 I Koschinsky, Marlys L Queen’s University The pathophysiology of Lp(a) in the arterial wall: effect of apo(a) on vascular cell function. Lipoprotein(a), apolipoprotein(a), kringles, atherosclerosis, endothelial dysfunction. 20062011 $96,899 $503,083 I Krahn, Andrew D; Gollob, Michael H; Birnie, David H University of Western Ontario Clinical and genetic assessment of primary electrical disease. Cardiac arrest, genetics, diagnosis, sudden death, drug infusion, genetic testing. 20062009 $94,976 $288,299 II Kutryk, Michael JB St. Michael’s Hospital Novel applications of progenitor endothelial cells. Progenitor endothelial cells, iPAH, HHR, angiogenesis, cardiac risk factors. 20052007 $43,450 $86,047 I, II Lanctôt, Krista L; Sahlas, Demetrios J; Gladstone, David J; Ween, Jon Erik; Herrmann, Nathan; Black, Sandra E Sunnybrook Health Sciences Centre The role of cytokine-serotonin interactions in post-stroke depression. Stroke, depression, tryptophan, serotonin, cytokines. 20062008 $57,770 $108,715 I, II Langille, B Lowell Toronto General Hospital Arterial responses to hemodynamic stresses. Remodeling, mechanotransduction, shear, tensile stress, elastin. 20022007 $113,203 $551,675 I Langille, B Lowell; Bendeck, Michelle P Toronto General Hospital Cadherins and regulation of smooth muscle cell function. Cadherin, polarity, migration, vascular smooth muscle, restenosis. 20042007 $75,845 $225,053 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 104 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Lee, Robert MKW; Gao, Yu-Jing McMaster University Alterations in hypertensive arteries. Hypertension, artery, fat, vascular remodeling, vascular growth. 20052008 $80,112 $234,997 I Leenen, Frans HH University of Ottawa Heart Institute Sympathetic and cardiac effects of blockers in the RAAS in rats. Brain, heart, renin-angiotensinaldosterone system, heart failure, blockers, sympathetic nerve activity. 20042007 $98,157 $276,923 I Leong-Poi, Howard M; Stewart, Duncan J; Gross, Peter L St. Michael’s Hospital Site-targeted imaging and delivery of cell-based therapy. Endothelial progenitor cells, targeted ultrasound imaging, therapeutic angiogenesis, chronic ischemia. 20062008 $73,682 $148,264 I Letarte, Michelle V Hospital for Sick Children Role of endoglin in normal vasculature and in the pathology of HHT. Vascular tone, endoglin, HHT, Vascular endothelium, gene profiling. 20052009 $91,804 $370,767 I Lewis, Gary F Toronto General Hospital Regulation of HDL metabolism. HDL, apolipoprotein A, hypertriglyceridemia, lipase. 20052008 $86,151 $260,873 I, II Leytin, Valery; Gross, Peter L St. Michael’s Hospital Platelet apoptosis induced by chemical agonists and shear stresses. Platelets, apoptosis, thrombosis, collagens, shear stress. 20052008 $83,023 $242,521 I Li, Ren-Ke; Fedak, Paul W Toronto General Hospital Gene-enhanced cell transplantation to reverse heart failure. Heart failure, growth factor, cell transplantation, myocardial hypertrophy, extracellular matrix. 20042007 $88,122 $259,216 I Li, Ren-Ke Toronto General Hospital Vasculogenesis induced by cell transplantation. Angiogenesis, cell transplantation, myocardial ischemia, cell culture, growth factors. 20032007 $90,901 $345,259 I Lillicrap, David; James, Paula D Queen’s University The role of von Willebrand factor in arterial thrombosis. von Willebrand factor, arterial thrombosis, genetics, mouse model. 20052008 $91,857 $275,669 I, II Liu, Fang Centre for Addiction and Mental Health Uncoupling the protein-protein interaction between mGluR5 and NMDA receptors: a new approach in the treatment of stroke. Metatropic glutamate receptors, NMDA receptors, neurotoxicity, protein-protein interaction, stroke. 20052007 $49,022 $98,044 I Liu, Peter P; Hinek, Aleksander Toronto General Hospital Aldosterone - receptor and non-receptor based mechanisms of repair and remodeling following cardiac injury. Aldersterone, remodeling, inflammation, signal transduction, elastase. 20042007 $100,513 $295,665 I Liu, Peter P; Medin, Jeffrey A Toronto General Hospital Homing signals and cell mobilization in cardiac remodeling post myocardial infarction. Heart failure, remodeling, cytokines, stem cells, progenitor cells, homing, innate immunity. 20062009 $95,158 $290,233 I, II Liu, Peter P; Stewart, Duncan J Toronto General Hospital T-cell based immune mechanisms of chlamydial vascular injury. Chlamydia, vascular injury, immune mechanisms, atherosclerosis. 20032008 $113,493 $556,560 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 105 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Liu, Peter P; Yeh, Wen-Chen Toronto General Hospital “Danger signal”, cell injury and “innate immune response” in regulating inflammation in cardiovascular disease. Inflammation, myocarditis, innate immunity, vaccine, heart failure. 20052010 $106,750 $544,636 I, II Lobe, Corrinne Sunnybrook Health Sciences Centre Transgenic mouse models to study the role of Notch in blood vessel development. Notch pathway, transgenic mice, angiogenesis. 20042007 $74,334 $221,640 I Lucas, Alexandra R; Spence, J David Robarts Research Institute Serpin regulation of innate immune response and vascular repair. Serpins, viral, inflammation, atherosclerosis, thrombolysis. 20062009 $78,892 $236,676 I MacLennan, David H University of Toronto Sites of interaction between phospholamban, sarcolipin and the cardiac calcium pump. 20022007 $138,229 $664,375 I Mak, Alan S Queen’s University Cortactin and caldesmon in vascular smooth muscle cell migration and invasion. Smooth muscle, cell motility, atherosclerosis, biochemistry, cell biology. 20062011 $93,313 $484,502 I Mak, Susanna Mount Sinai Hospital Estrogen and cardiac function in humans with and without heart failure. Sex, estrogen, ventricular function, heart failure. 20052007 $51,123 $101,705 II Marcel, Yves L; Kiss, Robert S University of Ottawa Heart Institute Role of GULP in engulfment and cellular cholesterol trafficking. GULP, cholesterol, efflux, engulfment, macrophages. 20062007 $35,000 $35,000 I Marcel, Yves L; McPherson, Ruth University of Ottawa Heart Institute The genetic basis of cholesterol efflux defects in hypoalphalipoproteinemia. Atherosclerosis, dyslipoproteinemia, cholesterol, efflux, lipoproteins. 20062009 $92,583 $280,989 I Marsden, Philip A University of Toronto Post-transcriptional regulation of eNOS expression. Nitric oxide, endothelium, atherosclerosis, transcription, translation. 20052009 $95,069 $380,276 I Marsden, Philip A University of Toronto Regulated expression of the human nNOS gene. Atherosclerosis, hypoxia, translation, nitric oxide, transcription. 20062011 $109,203 $562,240 I Marshall, John G; Cass, Dan Ryerson Polytechnic University Biophysical and biochemical approaches to the diagnosis of myocardial infarction and stroke. Serum, diagnostic, mass spectrometry, atherosclerosis, lovastatin. 20052007 $69,188 $143,088 I, II Martin, Ruth E; Hachinski, Vladimir University of Western Ontario Effects of oropharyngeal stimulation on swallowing recovery and cortical plasticity in hemispheric stroke: a randomized controlled trial with fMRI. Stroke, dysphagia, swallowing, orofacial, functional magnetic resonance imaging. 20042007 $87,700 $268,107 II Maurice, Donald H Queen’s University PDEs in blood vessels. cAMP, cGMP, sinalling, smooth muscle, endothelium. 20042008 $95,399 $379,466 I McBride, Heidi M University of Ottawa Heart Institute Mechanism and function of mitochondrial derived vesicles. Mitochondrial dynamics, MARi-1, DRP1, budding. 20062008 $84,892 $171,665 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 106 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal McCrindle, Brian W; Russell, Jennifer; Sananes, Renée; Longmuir, Patricia Hospital for Sick Children Identifying determinants and optimizing rehabilitation of physical activity for children after the Fontan Procedure. Fontan procedure, physical activity, behaviour change, psychosocial factors, children. 20062008 $62,184 $119,967 II McCulloch, Christopher AG; Seth, Arun University of Toronto Regulation of smooth muscle gene expression by mechanical loading. Actin, cardiac fibrosis, myofibroblast, mechanical tension, MAP kinases. 20042007 $90,653 $267,562 I McDermott, John C York University Role of MEF2 interacting proteins in cardiac development and hypertrophy. Cardiomyocytes, transcription, MEF2, gene expression, hypertrophy. 20062007 $35,000 $35,000 I McPherson, Ruth University of Ottawa Heart Institute Regulation of LRP gene expression. LRP, gene expression, adipocytes, lipoproteins. 20042007 $65,661 $193,252 I Megeney, Lynn Ottawa Health Research Institute Non-linear modeling of MAPK induced cardiac hypertrophy. 20052007 $67,745 $135,490 I Mehta, Sanjay; McCormack, David G Lawson Research Institute Microvascular endothelial cell injury in murine sepsis. Microvasculature, sepsis, endothelial cell, nitric oxide, neutrophil. 20052008 $89,805 $277,415 I Melo, Luis G; Dzau, Victor J; Pachori, Alok Queen’s University Cell based gene therapy to enhance healing and recovery of infarcted myocardium. Endothelial progenitor cell (EPC), genetic engineering, myocardial infarction, neovascularization. 20052007 $91,435 $181,341 I Melo, Luis G; Ward, Christopher A Queen’s University Cardiogenic differentiation of mesenchymal stem cells using transcription factors. Genetic engineering, lentivirus, mesenchymal stem cells, myocardial repair, transcription factors. 20062008 $81,959 $164,958 I Miller, Judith A; Cherney, David ZI Toronto General Hospital Impact of protein kinase C inhibition on hemodynamic function in type 1 diabetes mellitus. Protein kinase C, physiology, diabetes, hyperglycemia, angiotensin II. 20042007 $64,558 $127,850 II Milne, Ross W; Braschi, Sylvie F; Whitman, Stewart C University of Ottawa Heart Institute Advanced glycation end products and diabetic atherosclerosis. Advanced glycation end products, diabetes, atherosclerosis, transgenic mice. 20052007 $67,570 $133,815 I Min, Wei-Ping London Health Sciences Centre Cellular therapy for transplant rejection by T regulatory cells generated through interaction with genetically modified dendritic cells. Heart transplantation, tolerance, dendritic cell, RNA interference, immune modulation. 20052007 $70,667 $140,438 I Min, Wei-Ping London Health Sciences Centre Protection of heart grafts in transplantation through RNA interference. Heart transplantation, gene silencing, siRNA, immune tolerance, ischemia/reperfusion injury. 20062008 $76,140 $153,793 I Monnier, Philippe P Toronto Western Research Institute Mechanisms that control repulsive guidance molecule (RGM) biological activity. Neuronal survival, neuroregeneration, axonal outgrowth, brain ischemia, biochemistry, molecular biology. 20052007 $68,970 $137,940 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 107 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Morley, Paul National Research Council of Canada (Ottawa) Synaptic and extrasynaptic NMDA receptors in preconditioning. Preconditioning, tolerance, ischemia, stroke, neurotoxicity. 20052008 $66,024 $198,097 I Murkin, John M; Walley, Keith R; Sandford, Andrew J; Russell, James A; Lichtenstein, Samuel V London Health Sciences Centre Genetic determinants of cognitive dysfunction following cardiopulmonary bypass. Cardiopulmonary bypass, genes, polymorphisms, cognitive dysfunction. 20042007 $93,972 $276,424 III Nesheim, Michael E Queen’s University The activation of TAFI and the properties of TAFIa. TAFI, TAFIa, fibrinolysis, x-ray crystallography, thrombomodulin. 20052010 $86,077 $442,097 I, III Newton, Gary E Mount Sinai Hospital Free radical modulation of sympathetic activity and mechanical efficiency in the normal and failing human heart. Free radicals, heart failure, norepinephrine spillover, mechanical efficiency, vitamin C, nitric oxide. 20052008 $64,264 $192,792 I, II Newton, Gary E; Allard, Johanne Mount Sinai Hospital Investigations in dietary therapy in human heart failure. Heart failure, diet, sodium, hemodynamics, norepinephrine. 20062008 $57,450 $114,900 I, II Ni, Heyu St. Michael’s Hospital Novel mechanisms of platelet aggregation: role of alternative ligands of beta3 integrin in thrombosis and hemostasis. Platelet, thrombosis, integrin, hemostasis, vascular biology. 20052008 $65,517 $196,575 I Nurse, Colin A McMaster University Mechanisms regulating asphyxial responses in rat adrenal chromaffin cells. Chromaffin cells, asphyxia, patch clamp, nicotine, culture. 20062010 $104,641 $357,709 I, II, III, IV O’Brien, Edward RM University of Ottawa Heart Institute NM23-H2, an estrogen receptor beta associated protein: alterations in signal regulation and role in vascular cell function. Estrogen, receptors, atherosclerosis, coronary, hormones. 20052008 $70,284 $210,909 I, II, IV O’Brodovich, Hugh M Hospital for Sick Children New approach to augment clearance of pulmonary edema. 20052008 $84,980 $270,832 I O’Leary, Deborah D; Klentrou, Panagiota; Falk, Bareket; LeBlanc, Paul J Brock University The effects of body composition on arterial stiffness and baroreflex function in children. Obesity, children, arterial stiffness, baroreflex function, gender. 20062008 $47,935 $95,870 I Opas, Michal University of Toronto Calreticulin: cell and developmental biology. Calreticulin, calcium, adhesion, ES cells, differentiation, microscopy. 20042007 $100,003 $300,009 I Opavsky, Mary Anne Hospital for Sick Children The coxsackie-adenovirus receptor: function meets infection in viral myocarditis and dilated cardiomyopathy. Myocarditis, coxsackievirus, signal transduction, coxsackie-adenovirus receptor, MAPKs. 20052007 $86,858 $172,014 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 108 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Pandey, Siyaram; Tanner, WR University of Windsor Identification and functional characterization of unique single domain intrabodies against pro-apoptotic proteins and their application in the discovery of novel pharmacophore. Intrabodies, apoptosis, neuronal cell death, ischemia, anti-apoptotic intrabodies, phage display and pharmacophore libraries. 20062009 $77,000 $198,000 I Pang, Stephen C Queen’s University Pathogenesis of cardiac hypertrophy in ANP gene disrupted mice. Atrial natriuretic peptide, renin angiotensin system, cardiac hypertrophy, salt-sensitive hypertension, gene knockout mice. 20042007 $81,123 $238,629 I Park, David S University of Ottawa Oxidative stress and ischemic death. Stroke, oxidative stress. 20062008 $68,000 $137,160 I Park, David S; Albert, Paul University of Ottawa Mechanisms of delayed death in stroke. Central nervous system, stroke, behaviour abnormalities. 20042009 $80,600 $403,000 I Parker, John D Mount Sinai Hospital Neurochemical effects of different pacing modalities in CHF: insights from studies of cardiac and renal sympathetic activity. 20042007 $100,215 $300,645 II Parkinson, John; Keeley, Fred W Hospital for Sick Children A combined theoretical/ experimental approach to understanding sequence - structure - function relationships in elastin and elastin-like peptides. Elastin, biomechanics, bioinformatics, self-assembly, computer simulation. 20052007 $36,271 $74,831 I Parshuram, Christopher S; Hutchison, James S; Parkin, Patricia; Beyene, Joseph; Dryden-Palmer, Karen Hospital for Sick Children PEWS translation project: from retrospective algorithm to real-time bedside tool. Prevention, patient safety, early warning system. 20062008 $74,652 $147,643 II, III Peng, Tianqing; Feng, Qingping London Health Sciences Centre PLCgamma/IP3 signaling regulates cardiac TNF-alpha expression in sepsis. Sepsis, TNF-alpha, cardiomyocyte, phospholipase Cgamma, inositol trisphosphate. 20062009 $127,384 $323,859 I Pickering, J Geoffrey Robarts Research Institute Regulation of smooth muscle cell differentiation and longevity. Smooth muscle cell, cell maturation, cell longevity, NAD, vessel remodeling. 20052010 $103,128 $526,159 I Puri, Mira C Sunnybrook Health Sciences Centre Role of endoglin in mammalian cardiovascular development. Endothelium, endocardial cushion, embryogenesis, mouse models, arteriovenous malformation. 20062008 $69,349 $138,698 I Pyle, William Glen University of Guelph Hormonal regulation of myocardial function. Relaxin, myofilaments, intracellular signalling, mechanics, myocardium. 20052007 $53,560 $105,761 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 109 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Rand, Margaret L Hospital for Sick Children The procoagulant surface of activated platelets: persistence in vitro and in vivo. Platelets, thrombosis, procoagulant activity, platelet survival. 20042007 $80,092 $235,594 I Rao, Vivek University of Toronto Mechanisms of transplant related vascular injury. Endothelial injury, immunosuppression, endothelin, protein kinase C. 20062008 $63,000 $127,260 I Reid, Robert D; Pipe, Andrew L; Morrin, Louise IN; Higginson, Lyall AJ; Wells, George A; Blanchard, Chris M; Oldridge, Neil; Wielgosz, Andreas T University of Ottawa Heart Institute Efficacy and cost-effectiveness of behavioural counselling for exercise behaviour in men and women following AMI and PCI. Coronary artery disease, secondary prevention, early intervention, physical activity. 20052007 $70,322 $147,319 II, III Reid, Robert D; Pipe, Andrew L; Sherrard, Heather University of Ottawa Heart Institute An interactive, voice response-mediated, follow-up and triage system for smoking cessation in smokers with CHD. Smoking cessation, coronary disease, prevention, interactive voice response. 20062009 $72,820 $177,557 II, III, IV Renaud, Leo P Ottawa Health Research Institute Suprachiasmatic nucleus efferents. Patch clamp, cell electrophysiology, transmitters, biological clock, hypothalamus. 20052008 $58,207 $179,692 I Robinson, Lisa A Hospital for Sick Children Cellular regulation of fractalkine. 20052007 $85,972 $171,944 I Rochon, ELizabeth A; Leonard, Carol L; Grady, Cheryl; Graham, Simon J University of Toronto Neural, linguistic, and communicative changes after treatment for anomia in aphasia. Aphasia, rehabilitation, neuroimaging, communication. 20042007 $110,885 $323,604 I Rodger, Marc A; Walker, Mark C; Kingdom, John; Keating, Sarah J; Wen, Shi Wu; Yang, Qiuying; Smith, Graeme N Ottawa Health Research Institute TAPP - Thrombophilia and Placental Pathology. Pregnancy complications, cohort study, thrombophilia, placental villous infarction. 20052008 $41,080 $123,849 I, II, III, IV Roy, Eric A; Black, Sandra E; Dixon, Michael J; Danckert, James; Park, Norman W; Adams, Scott; Hebert, Deborah University of Waterloo Neuropsychological profiles and neuroimaging correlates of limb apraxia. Apraxia, aphasia, cognitive neuroscience, neuropsychology, cognitive neurology, movement control, manual asymmetries. 20042007 $45,643 $136,929 II Rubin, Barry B; Degousee, Norbert Toronto General Hospital Impact of mPGES-1 gene deletion on myocardial ischemia reperfusion injury. Prostaglandins, myocardial ischemia, heat shock proteins, mesenchymal stem cell, transgenic mice. 20052007 $79,511 $156,819 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 110 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Ruel, Marc; Beanlands, Rob SB; Suuronen, Erik J; de Kemp, Robert A; DaSilva, Jean N; Veinot, John P University of Ottawa Heart Institute Evaluation of biopolymer delivered EPCs for cardiac repair in a swine model of hibernating myocardium. Tissue engineering, endothelial progenitor cells, hibernating myocardium, animal models, PET. 20062008 $86,364 $175,743 I Rush, James WE University of Waterloo Exercise and antioxidants in hypertension: vascular endothelial adaptations. Exercise, hypertension, vascular endothelium, nitric oxide, oxidative stress. 20052007 $63,745 $126,241 I Schlichter, Lyanne C Toronto Western Research Institute Novel strategies to regulate microglia activation and neurotoxicity. Potassium channels, CNS inflammation, immune-cell activation. 20062009 $107,528 $280,936 I Schlichter, Lyanne C; Peeling, James; Corbett, Dale R Toronto Western Research Institute Targeting K channels to control inflammation in stroke. Intracerebral hemorrhage, focal ischemia, retinal ischemia, optic nerve transection, potassium channels, CNS inflammation, immune-cell activation. 20052008 $101,759 $312,391 I Sharma, Arya M; Anand, Sonia S; Tarnopolsky, Mark; Yusuf, Salim; Gerstein, Hertzel C; Pogue, Janice M McMaster University Biological determinants of the differences in metabolic and cardiovascular risk factors between South Asians and European caucasians. Ethnicity, obesity, diabetes, adipose tissue, skeletal muscle. 20052008 $99,304 $253,610 I, II, IV Sheffield, William P McMaster University Building novel antithrombotic serpins using directed or selectable mutational approaches. Serpins, thrombosis, protein engineering, thrombin, coagulation. 20052008 $64,416 $194,765 I Sheffield, William P McMaster University The clot-targeting properties of natural and engineered antiplasmins. Fibrinolysis, antiplasmin, fibrin, cross-linking, hirudin. 20062009 $80,694 $245,991 I Shoemaker, J Kevin; Cechetto, David F University of Western Ontario Central sympathetic control in humans. Functional magnetic resonance imaging, brain stem, sympathetic nerve activity, human, baroreceptors, sympathoinhibition. 20042007 $71,149 $212,491 II Silverman, Earl D; Bargman, Joanne M; Bradley, Timothy; Beyene, Joseph Hospital for Sick Children Role of chronic inflammation and systemic lupus erythematosus-related factors in the development of premature atherosclerosis in pediatric SLE. Atherosclerosis, systemic lupus erythematosis, risk factors for atherosclerosis, pediatrics, surrogate markers of atherosclerosis. 20062009 $120,545 $386,777 II, IV Silversides, Candice K; Siu, Samuel C; Colman, Jack M; Sermer, Mathew Toronto General Hospital Hemodynamic and hormonal changes in pregnant women with cardiac disease: understanding the effects of pregnancy on the disease heart. Pregnancy, heart disease, echocardiography, neurohormones. 20062008 $37,744 $75,488 II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 111 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Siu, Samuel C; Colman, Jack M; Sermer, Mathew Toronto General Hospital Maternal cardiac output and fetal well being in women with heart disease. Fetal well-being, maternal cardiac output. 20052007 $45,400 $90,800 II Slack, Ruth S University of Ottawa Regulation of MCL-1 to treat stroke. Stroke, apoptosis, neurons, transgenic mice, molecular. 20062011 $98,632 $507,077 I Sled, John G; Adamson, S Lee; Kingdom, John; Langille, B Lowell Hospital for Sick Children Three dimensional quantification of the placental vascular tree: relationship with normal and abnormal fetal growth and hemodynamics. Intrauterine growth restriction, micro-CT, placenta, microcirculation. 20062008 $65,283 $132,171 I, II Smith, Steven P Queen’s University Structural mechanisms of apolipoprotein(a)-ligand interactions: roles in Lp(a) assembly and function. Lipoprotein(a), apolipoprotein(a), kringle modules, protein-protein interactions, structural biology, atherosclerosis. 20062007 $35,000 $35,000 I Sorisky, Alexander Ottawa Health Research Institute Regulation of the pro-atherogenic adipokine IL-6 by TSH. 20042007 $87,154 $257,478 I Sparks, Daniel L University of Ottawa Heart Institute Regulation of ApoA-I synthesis and secretion by phosphatidylinositol. HDL, cholesterol, atherosclerosis, lipid metabolism, liver, intestine. 20062009 $98,580 $300,608 I Sparks, Daniel L University of Ottawa Heart Institute The role of HDL in triglyceride metabolism. HDL, cholesterol, apolipoproteins, lipases, heart disease. 20052008 $66,782 $197,087 I Spence, John David; Lucas, Alexandra R; Madrenas, Joaquin; Hegele, Robert A Robarts Research Institute Biomarkers in vulnerable carotid plaque with microemboli or ulcers. Atherosclerosis, hypothyroidism, clinical trials, 3D ultrasound plaque measurement. 20052008 $96,594 $289,820 I, II Spence, John David; Parraga, Grace; House, Andrew A; Fenster, Aaron Robarts Research Institute 3D ultrasound phenotypes and vascular risk. Atherosclerosis, vulnerable plaque, plaque volume, ulceration, cardiovascular risk. 20062009 $77,650 $276,529 II Stanimirovic, Danica B; Moreno, Maria J National Research Council of Canada (Ottawa) Astrocyte-endothelial cell interactions in hypoxia: role of P1GF in hypoxia-induced brain angiogenesis. Hypoxia, brain angiogenesis, neurovascular unit, placenta-growth factor, VEGF. 20062009 $71,000 $216,866 I Stewart, Duncan J; Husain, Mansoor; Han, Robin NN St. Michael’s Hospital NO synthase in cardiovascular health and disease. 20052008 $92,651 $278,047 I Sweeney, Gary York University Regulation of glucose and fatty acid uptake and metabolism in cardiomyocytes by adiponectin. 20052007 $63,000 $126,000 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 112 Adiponectin, glucose, fatty acid, obesity, diabetes. 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Tein, Ingrid Hospital for Sick Children Carnitine-responsive cardiomyopathy and the different-affinity carnitine transporters. Carnitine metabolism, carnitine transport, kinetic studies, expression studies, mouse model. 20042007 $88,826 $264,899 I Templeton, Douglas M University of Toronto Mechanisms of iron accumulation and toxicity in cardiac myocytes and interstitial fibroblasts. Iron overload, cardiac fibrosis, iron transport, cardiomyocyte, myofibroblast. 20052007 $73,030 $144,999 I Tesson, Frederique; Leenen, Frans HH; Ruel, Marc University of Ottawa Heart Institute Genetic approach to heart failure. Heart failure, human molecular genetics, candidate genes, expression levels, genetic risk factors. 20062008 $33,900 $68,178 I, II, IV Touyz, Rhian M University of Ottawa Vascular regulation by magnesium in hypertension. Magnesium, vessels, hypertension, oxidative stress, ion transport. 20052008 $95,704 $287,150 I Trigatti, Bernardo L McMaster University Effects of tissue specific expression or suppression of the HDL receptor SR-BI on atherosclerosis and coronary artery disease. Transgenic, knockout, HDL receptor, atherosclerosis, coronary artery disease. 20042007 $84,392 $250,809 I Tsushima, Robert G University of Toronto Regulation of cardiac nonselective cation channels. TRPC channels, electrophysiology, cardiac myocytes, caveolin, SNARE proteins. 20052007 $75,719 $150,514 I Tsushima, Robert G; Gaisano, Herbert Y University of Toronto SNARE protein modulation of cardiac Kv channels. Potassium channels, calcium channels, SNARE proteins, SLMAP, electrophysiology. 20062009 $78,002 $238,369 I Tu, Jack V; Alter, David A; Austin, Peter C; Ko, Dennis T; Lee, Douglas SY; Juurlink, David N; Mamdani, Muhammad M Institute for Clinical Evaluative Sciences-Toronto Improving the quality of acute myocardial infarction care in Canada. Acute myocardial infarction, health services research, quality of care, mortality, drug utilization, quality indicators. 20052008 $125,663 $377,033 II, III, IV Tuana, Balwant S University of Ottawa SLMAPs: sarcolemmal membrane associated proteins and E-C coupling. Sarcoplasmic reticulum, sarcolemma, membrane targeting, coiled-coil, E-C coupling. 20062010 $139,652 $567,651 I, II Tyml, Karel; Laird, Dale W University of Western Ontario Hypoxia/reoxygenation and vascular cell coupling. Microcirculation, capillary, endothelial cell, ischemia, reperfusion. 20052008 $92,527 $277,614 I Tyml, Karel; Wilson, John X; Kidder, Gerald Lawson Research Institute Microvascular dysfunction in sepsis. Microcirculation, capillary, endothelial cell, sepsis. 20062008 $92,724 $187,066 I Van Arsdell, Glen S; Li, Jia; Redington, Andrew N Hospital for Sick Children Analysis of the mechanism of altered systemic and cerebral oxygen transport in children with hypoplastic left heart syndrome undergoing stage I palliation. Oxygen transport, Norwood procedure, hypoplastic left heart syndrome, postoperative management, brain oxygenation. 20062009 $87,000 $264,428 II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 113 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Verma, Subodh; Stanford, William L St. Michael’s Hospital RasGRP3: a novel signaling protein and molecular target for endothelial progenitor cell mobilization and neovascularization. Vascular biology, angiogenesis, experimental mice models, ischemia. 20062008 $74,655 $151,767 I Wan, Qi Toronto Western Hospital PTEN suppression-mediated neuroprotection in stroke. Stroke, neuroprotection, PTEN phosphatase, NMDA receptor trafficking, signal transduction pathway. 20062008 $76,939 $154,851 I Wang, Hao; Zhong, Robert University of Western Ontario Tolerance induction through targeting memory T cells by blocking OX40 signaling pathway in presensitized recipients. 20062008 $80,626 $161,729 I Wang, Rui Lakehead University Role of BKCa channels of vascular smooth muscle cells in the development of hypertension. K channels, carbon monoxide, vascular contraction, smooth muscle cells, hypertension. 20062007 $65,000 $65,000 I Warkentin, Theodore E; Morgan, David G; Moore, Jane C McMaster University vWF multimers, cardiovascular disease, and bleeding angiodysplasia. von Willebrand factor, multimer, shear-dependent proteinase, aortic stenosis, peripheral vascular disease. 20042007 $92,383 $271,745 II Weisel, Richard D; Fazel, Shafie Toronto General Hospital Cardiac regeneration by cell transplantation. Myocardial infarction, ventricular remodeling, cardiac regeneration, matrix remodeling, angiogenesis. 20062009 $69,424 $212,216 I Weisel, Richard D; Fazel, Shafie Toronto General Hospital Enhancing endogenous repair by cell therapy. Myocardial infarction, ventricular remodeling, cardiac regeneration, matrix remodeling, angiogenesis. 20052007 $68,192 $136,384 I Weitz, Jeffrey I McMaster University Mechanisms of coronary catheter-induced clotting. Percutaneous coronary interventions, thrombosis, contact pathway anticoagulants. 20062010 $112,788 $462,837 I Weitz, Jeffrey I; Klement, Petr McMaster University Improving the effectiveness of thrombolytic therapy. Coagulation, fibrinolysis, anticoagulants, plasminogen activators, thrombolysis. 20042008 $110,288 $438,223 I Wells, James W University of Toronto Nature of the signalling complex between cardiac muscarinic receptors and G proteins. Heart disease, muscarinic cholinergic receptor, G protein, co-operativity, oligomers, signalling mechanism. 20052008 $83,433 $254,801 I Wells, Philip S; Kahn, Susan R; Anderson, David R; Ottawa Health Research Institute The role of inflammation and thrombophilia in the postthrombotic syndrome: the bio-sox study. Post-thrombotic syndrome, predictors, thrombophilia, SNP analysis, inflammation, D-dimer. 20052007 $48,670 $99,115 II Genest, Jr, Jacques; Kovacs, Michael J; Rodger, Marc A; Shapiro, Stanley H *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 114 06-07 $ Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée co-chercheur(s) principal Wen, Shi Wu; Walker, Mark C; Krewski, Daniel; Smith, Graeme N; Yang, Qiuying Ottawa Health Research Institute Environmental carbon monoxide (CO) level and the risk of pre-eclampsia (PE). Pre-eclampsia, carbon monoxide, cardiovascular risk, population health, epidemiology. 20052007 $35,604 $56,839 IV Werstuck, Geoffrey H; Capretta, Alfredo McMaster University Investigating the role of GSK3 in atherogenesis: rational design, synthesis and screening of novel GSK3 inhibitors as antiatherogenic therapies. Atherosclerosis, glycogen synthase kinase (GSK)-3, inhibitors, diabetes mellitus, hyperhomocysteinemia. 20052007 $72,931 $144,233 I West, Lori J Hospital for Sick Children Investigation of neonatal immune tolerance induced by the ABO-incompatible heart transplantation in a murine model. Heart transplant, immune tolerance, neonatal, ABO antigens, molecular chimerism. 20042007 $103,713 $306,840 I West, Lori J Hospital for Sick Children Mechanisms of cardiac allograft tolerance induced during immaturity. Tolerance, neonatal, transplantation, heart graft, rejection. 20032007 $89,045 $348,704 I Whitman, Stewart C University of Ottawa Heart Institute The role of innate immune system in atherosclerosis: defining the contribution of both natural killer cells and natural killer T cells to the disease process. Atherosclerosis, LDLr -/- mice, laser capture microdissection, microarray analysis, histology. 20052008 $97,954 $293,892 I Wisenberg, Gerald; Prato, Frank S; Merrifield, Peter A London Health Sciences Centre Optimizing the administration of marrow-derived stem cells to repair left ventricular structure and function in a canine model of myocardial infarction. Myocardial infarction, stem cell delivery, magnetic resonance imaging, positron emission tomography, SPECT imaging. 20052007 $99,849 $198,879 I Wittnich, Carin University of Toronto Impact of gender and sex hormones on myocardial pathology & responses to ischemia/reperfusion. Gender, estrogen, testosterone, progesterone, hypertrophy, SERM, metabolism, function. 20042007 $86,197 $253,552 I Yao, Zemin University of Ottawa Heart Institute Functional analysis of apoB R463W mutation associated with human familial hypobetalipoproteinemia. Hypertriglyceridemia, apoCIII, VLDL assembly, cell culture, transgenic mice. 20042007 $69,927 $208,027 I Yao, Zemin University of Ottawa Heart Institute Hepatic lipase and hypoalphalipoproteinemia. Hepatic lipase, cholesterol, lipoproteins, recombinant DNA, transgenesis. 20052007 $65,743 $130,208 I Yeung, Rae SM Hospital for Sick Children Towards a better understanding of Kawasaki Disease. Kawasaki Disease, superantigens, peptides, t-cells, pathogenesis. 20062008 $79,847 $160,565 I, II Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé 06-07 $ Total $* Theme Thème IV: Population Health IV : Santé de la population 115 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal et Institut du chercheur Durée 06-07 $ Total $* co-chercheur(s) principal Yusuf, Salim; McQueen, Matthew J; Anand, Sonia S; Teo, Koon K; Merchant, Anwar T McMaster University The INTERHEART study. Risk factors, myocardial infarction, ethnicity. 20052008 $148,575 $354,548 IV Zaidi, Syed, HE University Health Network Roles of growth differentiation factor 5 and bone morphogenetic protein 4 in cardiovascular diseases. Myocardial infarct, smooth muscle proliferation, growth factor, angiogenesis, transgenic mice, bone morphogenetic protein signalling. 20062008 $80,040 $161,201 I Zha, Xiaohui Ottawa Health Research Institute ABCA1-mediated cholesterol efflux and intracellular cholesterol transport. ABCA1, cholesterol, membrane, fluorescent microscopy, trafficking. 20052008 $69,317 $207,951 I Zhang, Liang Toronto Western Hospital Hippocampal hyperexcitability in rats after prolonged postischemic survival: a model of post-stroke epileptic seizures. 20052007 $66,008 $132,016 I Theme Thème Quebec | Québec 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Agharazii, Mohsen Hôtel-Dieu de Québec Determinants of progression of human aortic stiffness in renal failure: role of advanced glycation end products, oxidative stress, endotheline-1 and inflammation. Arterial stiffness, advanced glycation end-products, oxidative stress, inflammation, renal failure. 20062009 $13,700 $13,700 I, II Allen, Bruce G Montreal Heart Institute Molecular pharmacology of endothelin receptors in adult rat ventricular myocytes. Endothelin, receptor, G protein, cardiac myocyte, adult 20042007 $18,000 $60,500 I Anand-Srivastava, Madhu B Université de Montréal Role of oxidative stress in diabetes/hyperglycemia-induced impaired G-protein signaling and cell function/proliferation. Diabetes, hyperglycemia, oxidative stress, adenylyl cyclase, G-protein, vascular smooth muscle. 20042007 $13,700 $44,700 I Arsenault, Marie; Couet, Jacques; Elkouri, Stephane; Gaboury, Louis Hôpital Laval Cardiac adaptations to chronic aortic regurgitation. Aortic valve, regurgitation, ventricular function, echocardiography. 20052008 $18,000 $35,500 I, II Bachelard, Hélène; Larivière, Richard Centre hospitalier de l’Université Laval Role of endothelial NO in vascular and metabolic dysfunctions related to insulin resistance. Insulin resistance, endothelial dysfunction, vascular reactivity, regional blood flow, in vivo gene transfer 20042007 $13,700 $44,700 I $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 116 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Barbier, Olivier Université Laval Inhibition of bilirubin glucuronidation by cholesterol-lowering drugs: a novel mechanism for the reduction of atherogenesis. Bentourkia, M’hamed MB; de Kemp, Robert A; Lecomte, Roger; Gollob, Michael H; DaSilva, Jean N; Beanlands, Rob S Université de Sherbrooke Quantitative molecular PET imaging in mouse models of heart disease. Billette, Jacques Université de Montréal Role of dual pathways in rate-dependent AV nodal responses. Bkaily, Ghassan Université de Sherbrooke Blanchet, Sophie SB 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 20052008 $13,700 $26,700 I, IV 20062009 $13,700 $13,700 I Electrophysiology, AV node, dual pathways, supraventricular tachyarrhythmia mechanisms. 20042007 $13,700 $44,700 I Modulation of nuclear calcium cycling by ET-1 in heart cells. Nucleus, endothelin-1, pharmacology, calcium heart. 20042007 $13,700 $44,700 I Institut de réadaptation en déficience physique de Québec Rehabilitation of episodic memory disorders in patients with frontal stroke: impact on cerebral organization and life habits. Neuropsychology, memory, cognitive rehabilitation, event-related potentials, frontal stroke, life habits. 20052008 $13,700 $26,700 I, II, IV Blostein, Mark D Lady Davis Institute for Medical Research Physiology of gas6-Ax1 interactions in endothelial cells. Ax1, gas6, endothelium, apoptosis, gamma-carboxylation. 20062009 $13,700 $13,700 I Bogaty, Peter; Brophy, James M Hôpital Laval Evaluation of a novel multimarker approach (CRP and P-selectin) to risk stratification in acute coronary syndromes. CRP, inflammation, adhesion molecule, acute coronary syndrome. 20052008 $13,700 $26,700 II Boulay, Guylain Université de Sherbrooke Rôles des canaux TRPCs dans les cellules du systeme cardiovasculaire. TRPC, signalisation, calcium, muscle lisse, biologie moleculaire. 20062009 18 000 $ 18 000 $ I Bouvier, Michel Université de Montréal Molecular mechanisms controlling the signaling efficacy and selectivity of dynamic G protein-coupled receptor signaling complexes. Receptors, regulation, posttranslational modification, signaling efficacy, G-proteins. 20062009 $18,000 $18,000 I Brissette, Louise Université du Québec à Montréal Oxidized LDL metabolism. Lipoprotein, oxidation, cholesterol, SR-BI, CD36. 20062009 $18,000 $18,000 I Brophy, James M; Yusuf, Salim; Rouleau, JeanLucien; Joseph, Lawrence McGill University Beta-blockers in congestive heart Beta-blockers, meta-analysis, failure (CHF): a meta-analysis congestive heart failure, based on individual patient data. individual patient data, subgroup analysis. 20052007 $18,000 $35,500 II, IV Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique Bilirubin, anti-oxidant, atheroprotection, glucuronidation, cholesterol-lowering drugs. III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 117 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Calderone, Angelo Montreal Heart Institute Cardinal, René Carpentier, André C 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 Neural stem cells and scar remodelling. Reparative fibrosis, myofibroblasts, ANP, sympathetic system, transgenics. 20062009 $13,700 $13,700 I Hôpital du SacréSubstrates of reentrant Coeur de Montréal ventricular tachycardias in the pathologic ventricle. Ventricular tachycardia, myocardial ischemia, congestive heart failure, multi-point mapping, cellular electrophysiology, antiarrhythmic drugs. 20052008 $18,000 $35,500 I Université de Sherbrooke Intravascular lipolysis of triglyceride-rich lipoproteins on myocardial substrate selection in nutritional rat models of insulin resistance and type 2 diabetes. Lipoprotein metabolism, diabetes, insulin resistance, myocardial metabolism, positron emission tomography. 20042007 $18,000 $59,087 I Chahine, Mohamed Hôpital Laval Le canal sodique cardiaque et son rôle dans la génèse des troubles du rythme. Canal sodique, Nav1.5, coeur, arythmie, syndrome de Brugada, fibrillation ventriculaire, patch clamp. 20062009 18 000 $ 18 000 $ I Chalifour, Lorraine E; Sebag, Oga Sir Mortimer B. Davis Jewish General Hospital The role of gender-dependent differences in calcium homeostasis protein expression in dictating the response to catecholamine stress. Gender, calcium homeostasis proteins, gene expression, catecholamine, cardiac physiology. 20062009 $18,000 $18,000 I Chemtob, Sylvain Hôpital SainteJustine Mechanisms of hypercapniainduced retinal vasoobliteration: implications in retinopathy of prematurity. Free radicals, nitric oxide, retina, cell death, thromboxane. 20042007 $13,700 $44,700 I Claing, Audrey Université de Montréal Regulation of G protein-coupled receptor function by ARF6. G protein-coupled receptor, endothelial and vascular smooth muscle cells, small GTPases, endocytosis, cell migration. 20062009 $13,700 $13,700 I Couet, Jacques; Arsenault, Marie Institut de cardiologie de Québec Aortic valve stenosis in small animal models. Heart valve diseases, aortic stenosis, atherosclerosis, metabolic syndrome, animal models. 20062009 $13,700 $13,700 I Couture, Réjean Université de Montréal Kinin receptors in diabetes and hypertension. Neuropeptides, autonomic nervous system, CNS, diabetes, hypertension. 20062009 $13,700 $13,700 I Ditto, Blaine; Bacon, Simon L; Arsenault, André; Campbell, Tavis McGill University Blood pressure, pain sensitivity, and silent ischemia. Pain sensitivity, hypoalgesia, blood pressure, hypertension, silent ischemia. 20052008 $18,000 $35,500 I, II Drolet, Benoit Université Laval The possible role of diabetes in drug-induced cardiac proarrhythmia. Electrophysiology, diabetes, patch-clamp, action potentials, ECG, QT-prolonging drugs. 20062009 $18,000 $18,000 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 118 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 Drolet, Guy; Centre hospitalier Mouginot, Didier M de l’Université Laval Opioid regulation of salt intake. Neuroregulation, salt appetite, opioid peptide, salt-sensitive hypertension. 20042007 $13,700 $44,700 I Eisenberg, Mark J; Pilote, Louise; Lawrence, Joseph; O’Loughlin, Jennifer; Paradis, Gilles Sir Mortimer B. Davis Jewish General Hospital The ZESCA trial. Smoking cessation, epidemiology, clinical trials, acute coronary syndrome. 20042007 $13,700 $44,700 II Filep, Janos Hôpital MaisonneuveRosemont Inhibition of C-reactive proteinmediated inflammation by aspirin-triggered lipoxins. C-reactive protein, inflammation, leukocyte, aspirin-triggered lipoxins, acute coronary syndromes. 20062009 $13,700 $13,700 I Fiset, Céline Montreal Heart Institute Male-female differences in cardiac repolarization: hormonal regulation of cardiac K+ channel expression. Potassium channels, electrophysiology, mouse heart, gender difference, sex steroid hormones. 20042007 $13,700 $44,700 I Gallo-Payet, Nicole; Payet, Marcel-Daniel Université de Sherbrooke Rôle de l’angiotensine II dans les cellules glomérulees de la glande surrénale. Implication de l’environment cellulaire. Récepteurs AT1, angiotensine II, cellules glomérulées, fibronectine, intégrines, cytosquelette. 20042007 13 700 $ 44 700 $ I Genest, Jacques; Marcil, Michel; Rashid, Shirya Royal Victoria Hospital HDL genetics: the molecular cellular physiology of cholesterol efflux defect not caused by ABCA1 mutations. Cholesterol, high density lipoproteins, ATP binding cassette AI (ABCA1), apolipoprotein AI, cellular cholesterol transport. 20062009 $18,000 $18,000 I, II Giaid, Adel Montreal General Hospital Cardiovascular significance of urotensin-II system deletion and overexpression. Urotensin-II, heart failure, atherosclerosis, transgenic mice, knockout mice. 20052008 $13,700 $26,700 I Glavinovic, Mladen I McGill University Dynamics of catecholamine release and release of vesicular content in neuroendocrine cells. Catecholamine secretion, electrophysiology, parameter estimation, molecular dynamics, electro-osmotic and nano-fluidic simulations. 20062009 $13,700 $13,700 I Gobeil, Fernand Université de Sherbrooke Novel localization of nuclear kinin B2 receptors and functional correlates. 20062009 $13,700 $13,700 I Greenwood, Michael T McGill University Functional analysis of the cardiac and skeletal muscle specific RGS5. Signal transduction, G protein coupled receptors, molecular cardiology, yeast genetics, mutagenesis, regulators of G-protein signalling (RGS). 20042007 $13,700 $44,700 I Guillemette, Gaétan Université de Sherbrooke Propriétés moléculaires et fonctionnelles des récepteurs de l’inositol 1,4,5-trisphosphate dans l’endothélium. Endothélium, récepteur de l’inositol 1,4,5-trisphosphate, calcium phosphorylation, signalisation intracellulaire. 20052008 18 000 $ 35 500 $ I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 119 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Gutkowska, Jolanta; Jankowski, Marek; Coderre, Lise Centre hospitalier de l’Université de Montréal Role of the insulin regulated aminopeptidase (oxytocinase) in the heart. Insulin regulated aminopeptidase, insulin action, pregnancy, natriuretic peptides. 20062009 $18,000 $18,000 I Hébert, Terence E McGill University Composition, ontogeny and biosynthesis of specific GPCR signaling complexes. Signaling, G proteins, organization, heart failure, adrenergic receptors. 20052008 $13,700 $26,700 I Hussain, Sabah NA Royal Victoria Hospital Role of NADPH oxidase in signalling and biological effects of the angiopoietin-1/tie-2 pathway in endothelial cells. Angiogenesis, apoptosis, oxygen radicals, NADPH oxidase, endothelial cells. 20052008 $13,700 $26,700 I Jacques, Danielle Université de Sherbrooke Regulation of cytosolic and nuclear calcium by angiotensin II in endocardial endothelial cells. Angiotensin II, receptors, intracellular calcium, confocal microscopy, receptor mapping. 20042007 $13,700 $44,700 I Jolicoeur, Paul Clinical Research Institute of Montreal Studies of cardiac disease in CD4C/HIV transgenic mice. 20052008 $13,700 $26,700 I Jones, Peter JH McGill University Effects of plant sterol supplemen- Phytosterols, exercise, tation and exercise training cholesterol, cholesterol cholesterol kinetics and cardiometabolism, LDL particle size. vascular disease risk parameters in previously sedentary adults. 20042007 $13,700 $44,700 II Julien, Pierre; Fraser, William D Centre hospitalier de l’Université Laval Dyslipoproteinemia and oxidative stress in preeclampsia; a risk factor for endothelial dysfunction and vascular diseases. 20042007 $13,700 $44,700 I Kahn, Susan R; Wells, Philip S; Anderson, David R; Genest, Jr, Jacques; Kovacs, Michael J; Rodger, Marc A; Shapiro, Stanley H Sir Mortimer B. Davis Jewish General Hospital The role of inflammation and thrombophilia in the post-thrombotic syndrome: the bio-sox study. Post-thrombotic syndrome, predictors, thrombophilia, SNP analysis, inflammation, D-dimer. 20052008 $14,614 $28,803 II Lamontagne, Anouk; Fung, Joyce; McFadyen, Bradford J; Faubert, Jocelyn McGill University Visuomotor control of locomotion after stroke. Rehabilitation, locomotion, virtual reality, motor control, vision. 20052008 $13,700 $26,700 I, II Lamontagne, Daniel Université de Montréal Cardioprotective properties of the endogenous cannabinoid system. Myocardial infarction, cannabinoids, cytokines, nuclear receptor PPAR. 20052008 $13,700 $26,700 I Lanfranchi, Paola A; Montplaisir, Jacques Y Hôpital du SacréCardiovascular autonomic Coeur de Montréal regulation during sleep and wakefulness in primary insomnia. Insomnia, sleep, autonomic nervous system, blood pressure. 20052008 $13,700 $26,700 II $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 120 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Larivière, Richard Hôtel-Dieu de Québec Role of TGF-beta 1 in vascular endothelial dysfunction. Hypertension, renal failure, endothelium, blood vessels, vasoactive factors. 20062009 $13,700 $13,700 I Lavoie, Julie L Centre hospitalier de l’Université de Montréal Role of tissue-specific renin-angiotensin system in adipose tissue in obesity and obesity-related hypertension. Obesity, obesity-related hypertension, reninangiotensin system, adipose tissue. 20062008 $18,000 $18,000 I Leduc, Richard; Lavigne, Pierre; Escher, Emmanuel; Klarskov, Klaus Université de Sherbrooke Molecular mechanisms of urotensin II. 20062009 $13,700 $13,700 I Lerouge, Sophie; Soulez, Gilles; Gaboury, Louis; Elkouri, Stephane Université de Montréal Healing and endoleaks following endovascular repair of abdominal aortic aneurysms: an analysis of explanted stent-grafts. Aneurysms, endovascular treatment, healing process, stent-graft, explants. 20052007 $13,700 $26,700 I Lesur, Olivier; Lecomte, Roger; Bentourkia, M’hamed MB Université de Sherbrooke Impact of fluid resuscitation on endotoxin-induced heart dysfunction. Septic shock, myocardial dysfunction, PET scan imaging, myocardial apoptosis, fluid resuscitation. 20062009 $18,000 $18,000 I Magder, Sheldon A McGill University Role of vascular vs phagocytic NAD(P)H oxidase in the septic response. Sepsis, reactive oxygen species, microcirculation inflammation, lung injury, NFkB. 20062009 $18,000 $18,000 I Merhi, Yahye Institut de cardiologie de Montréal Thrombo-inflammatory roles of platelet P-selectin/PSGL-1 interactions. Adhesion molecules, neutrophils, platelets, endothelium, restenosis. 20052008 $18,000 $35,500 I Miller, Sydney B; Fellows, Lesley K; Mayo, Nancy; Koski, Lisa; Ludson, Ronald; Gagnon, Bruno Concordia University Tracking the dynamics of depression in older persons with stroke. Stroke, depression, assessment, lesion, cognitive. 20062008 $13,700 $13,700 I, II, III Moreau, Pierre Université de Montréal Mechanisms of mineral loss in medial elastocalcinosis (medial arterial calcification): a therapeutic opportunity for isolated systolic hypertension. Endothelin, elastocalcinosis, aortic stiffness, extracellular matrix. 20062009 $18,000 $18,000 I Mounier, Catherine Université du Québec à Montréal Hormonal regulation of stearyl Stearyl CoA desaturase, CoA desaturase gene: importance insulin, leptin, liver, obesity. of obesity and diabetes. 20042007 $13,700 $44,700 I MukaddamDaher, Suhayla; Gutkowska, Jolanta Centre hospitalier de l’Université de Montréal Cardiac effects of chronic imidazoline receptor activation in heart failure. 20052008 $13,700 $26,700 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale $ cumulatif reçu en 2007 II: Clinical II : Clinique Heart failure, imidazoline receptors, moxonidine, natriuretic peptides, cytokines, apoptosis. III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 121 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Nattel, Stanley Montreal Heart Institute Factors influencing the interaction of antiarrhythmic drugs with cardiac tissues. Sudden death, ventricular tachycardia, ion channels, remodeling, molecular biology. 20042007 $18,000 $60,500 I Noiseux, Nicolas Centre hospitalier de l’Université de Montréal Angiogenic and paracrine effects of bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction. Adult stem cells, myocardial infarction, cardiac repair, angiogenesis, paracrine. 20062009 $13,700 $13,700 I Nuyt, Anne Monique Hôpital SainteJustine Role of oxidative stress in fetal programming of hypertension. Hypertension, programming, oxidant, vascular, brain. 20042007 $13,700 $44,700 I Orlov, Sergei N; Tremblay, Johanne; Hamet, Pavel Centre hospitalier de l’Université de Montréal Cloning and functional characterization of Na+/Li+ countertransporter. Na+/Li+ countertransport, Na+/H+ exchange, cloning, proteomics, hypertension. 20042007 $13,700 $44,700 I Parent, Lucie Université de Montréal Molecular determinants of gating Calcium, ion channel, in voltage-gated Ca channels. electrophysiology, regulation, scaffolding proteins. 20052008 $18,000 $35,500 I Pausova, Zdenka; Gaudet, Daniel; Leal, Suzanne M Centre hospitalier de l’Université de Montréal Long term cardiovascular and metabolic consequences of prenatal exposure to maternal cigarette smoking in French Canadian adolescents. 20052008 $13,700 $26,700 I, II, IV Perrault, Louis P Montreal Heart Institute Mechanisms of pulmonary arterial endothelial dysfunction following cardiopulmonary bypass in cardiac surgery: impacts on hemodynamics, oxygenation and development of preventive and therapeutic strategies. 20052008 $13,700 $26,700 I, II, III, IV Pharand, Chantal; Diodati, Jean G; Amyot, Robert Hôpital du SacréDeterminants of subendocardial Subendocardial ischemia, Coeur de Montréal ischemia at normal heart rate in a myocardial perfusion, porcine model. myocardial contrast echocardiography, platelet mediators. 20062009 $13,700 $13,700 I Pibarot, Philippe; Dumesnil, Jean G; Després, JeanPierre; Mathieu, Patrick Université Laval Metabolic determinants of the progression of aortic stenosis. 20062009 $18,000 $18,000 I, II Powell, William S McGill University Eicosanoids and leukocyte and endothelial cell function. 20062009 $18,000 $18,000 I Raymond, Jean Centre hospitalier de l’Université de Montréal Inhibition of recanalization after coil embolization of intracranial aneurysms with endothelial denudation and in situ beta radiation. 20052008 $13,700 $26,700 I $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 122 Metabolic syndrome, adolescence, fetal programming, maternal cigarette. Valvular heart disease, aortic stenosis, metabolism, metabolic syndrome, doppler-echocardiography. Brain aneurysm, recurrence, endothelial denudation, beta radiation, animal models of human disease. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Richard, Darren E Hôtel-Dieu de Québec Rousseau, Guy Hôpital du SacréPost-ischemic cardioprotection Coeur de Montréal by A2A adenosine receptors. Sauvé, Remy Université de Montréal Molecular studies of IKCa gating in endothelial cells. Servant, Marc Université de Montréal Roles of interferon regulatory factor-3 and NF-kB transcription factors in the induction of pro-atherosclerotic conditions by classical as well as emerging risk factors. Shrier, Alvin; Glass, Leon McGill University Sirois, Martin G 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 Vascular smooth muscle, angiogenesis, hypoxia, HIF, angiotensin. 20052008 $18,000 $35,500 I Myocardial, reperfusion, infarction, adenosine, signalisation. 20042007 $13,700 $44,700 I 20052008 $18,000 $35,500 I Inflammation, angiotensin II, pathogens, NF-kB, interferon-regulatory factors, signal transduction mechanisms. 20062009 $13,700 $13,700 I Dynamics and remodeling of cultured cardiac cells. Tissue culture, optical mapping, cardiac electrophysiology, nonlinear mathematics, pacing. 20062009 $13,700 $13,700 I Montreal Heart Institute Agonistic activities of angiopoietins on neutrophils. Angiopoietins, Tie2 receptor, neutrophils, cell signaling, inflammation. 20062009 $18,000 $18,000 I St Louis, Jean Hôpital SainteJustine Régulation de la circulation placentaire par les prostanoides, comparaison de la grossesse normale et la prééclampsie. Placenta, prééclampsie, vaisseaux sanguins, soprostanes, prostaglandines. 20042007 13 700 $ 44 700 $ I St-Amand, Jonny; Raymond, Vincent Université Laval Effects of high-fat meal on transcriptomes and characterization of novel appetite-satiety genes. Obesity, coronary artery disease, functional genomics, gene discoveries, high fat diet. 20052008 $13,700 $26,700 I, II, III, IV Stochaj, Ursula McGill University Protein trafficking in stressed cells. Nuclear transport, heat shock proteins, hsp/hsc70s, oxidative stress, ischemia/reperfusion. 20042007 $18,000 $60,500 I Tanguay, JeanFrançois Montreal Heart Institute Role of estrogens and estrogen receptors (ER alpha and ER beta) in vascular healing. Estrogen, estrogen receptors, atherosclerosis, restenosis, acute coronary syndromes. 20042007 $13,700 $44,700 I Thibault, Gaétan Institut de recherches cliniques de Montréal Hétérogénéité des fibroblastes cardiaques. Cardiac fibroblasts, fibrosis, inflammation, Thy-1 protein, CD40. 20052008 13 700 $ 26 700 $ I Thorin, Eric; Ferland, Guylaine; Hamel, Edith Montreal Heart Institute Mechanisms and cognitive consequences of cerebrovascular dysfunction in aging and dyslipidemia. Cerebrovascular dysfunction, aging, dyslipidemia, cerebral blood flow, cognitive impairment. 20062009 $13,700 $13,700 I Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale Vasoactive hormones and hypoxia in the control of vascular hypoxic genes. II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 123 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal Institut du chercheur et co-chercheur(s) principal Tremblay, Angelo; Després, JeanPierre; Richard, Denis; Lamarche, Benoit; Blundell, John Université Laval Clinical evaluation to improve obesity intervention prescription: functional foods as a potential solution for low satiety quotient phenotype? Turgeon, Jacques Université de Montréal Drug-induced long QT syndrome: the modulatory role of P-glycoprotein (MDR1). Wang, Zhiguo Montreal Heart Institute Kr/HERG K+ channel as a critical molecular contributor to electrical disorders during acute myocardial ischemia: extracellular K+ accumulation and “Short QT Syndrome”. White, Michel; Touyz, Rhian M Montreal Heart Institute Wu, Jiangping Centre hospitalier de l’Université de Montréal 06-07 $ Cumulative $ Theme to 2007 Thème $ cumulatif reçu en 2007 20042007 $13,700 $44,700 II Electrophysiology, antiarrhythmics, proarrhythmia, p-glycoproteins, drug-interactions. 20052008 $18,000 $35,500 I Myocardial ischemia, potassium, arrhythmias, IKr/ HERG, LPC. 20052008 $13,700 $26,700 I Inflammation, oxidative stress, and exercise capacity and recovery in congestive heart failure and in chronic obstructive pulmonary disease. 20052008 $13,700 $26,700 I, II, IV Immune regulation in heart trans- Transplantation, death decoy plantation. receptor 3, T cell migration. 20052008 $18,000 $35,500 I 06-07 $ New Brunswick | Nouveau-Brunswick Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal Institut du chercheur Durée et co-chercheur(s) principal Cheema, Sukhinder Memorial K University of Newfoundland Mechanisms of regulation of triacylglycerol and cholesterol metabolism by dietary lipids. Atherosclerosis, fish oil, lipoprotein lipase, transcription factors, oxidative stress. 20062007 $40,000 $40,000 I Chen, Robert PC IWK Health Centre Remodelling of the intrinsic cardiac nervous system by left to right cardiac shunts. Intrinsic cardiac neuron, shunt, stent, ductus arteriosus, congenital heart disease. 20062009 $47,000 $141,000 I Currie, R William Dalhousie University Heat shock proteins and cardiovascular protection. Heat shock proteins, blood vessels, inflammation, heart, brain. 20062009 $47,000 $141,000 I Legare, JeanFrancois Dalhousie University Kinetics of neutrophil trafficking in post ischemic myocardium. Neutrophil, inflammation, myocardial infarction, cell adhesion, chemokines. 20062009 $47,000 $141,000 I McDonald, Terence F Dalhousie University ATP-sensitive K+ channels in heart cells. Ventricular myocytes, voltage-clamp, K-ATP channels, regulation, site-directed mutagenesis. 20042007 $72,160 $172,160 I *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 124 Total $* Theme Thème Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Chercheur principal Institut du chercheur Durée 06-07 $ Total $* et co-chercheur(s) principal Ridgway, Neale D Dalhousie University Functional analysis of the role of two oxysterol binding proteins in lipid homestasis. Cholesterol, oxysterols, lipid transport, protein-protein interactions. 20052008 $50,000 $150,000 I Schlichter, Lyanne C; Peeling, James; Corbett, Dale R Toronto Western Research Institute Targeting K channels to control inflammation in stroke. Intracerebral hemorrhage, focal ischemia, retinal ischemia, optic nerve transection, potassium channels, CNS inflammation, immune-cell activation. 20052008 $46,000 $138,000 I Theme Thème Nova Scotia | Nouvelle-Écosse 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Easton, Alexander S Dalhousie University An investigation of the role played by free radicals and calcium in neutrophil dependent alterations in permeability across the blood-brain barrier. Blood-brain barrier, neutrophil, permeability, calcium, free radical. 20042007 $47,000 $141,000 I Eskes, Gail A; Klein, Ray Dalhousie University Rehabilitation of attention in hemi-spatial neglect. Hemi-spatial neglect, rehabilitation, stroke, neuropsychology, attention. 20042007 $47,053 $142,800 II Gardner, Martin J; Horacek, B Milan Dalhousie University Electrocardiographic characteristics of arrhythmogenic right ventricular cardiomyopathy. Cardiac clinical electrophysiology, biomedical engineering. 20062009 $44,000 $44,000 I, II Howlett, Susan E; Ferrier, Gregory R Dalhousie University Ischemic preconditioning in ventricular myocytes from young adult and aged animals. Aging, ischemia and reperfusion, ischemic preconditioning, arrhythmias, ventricular myocyte. 20062009 $47,000 $47,000 I MacRae, Thomas H Dalhousie University Structural and functional characterization of small heat shock proteins: molecular chaperone activity during physiological stress. Molecular chaperones, small heat shock proteins, physiological stress, ischemia/ reperfusion injury, heart. 20052008 $50,000 $100,000 I Marsh, Daniel R Dalhousie University Spared bulbospinal axons can prevent autonomic dysreflexia from developing after spinal cord injury. Spinal cord, episodic hypertension, autonomic dysreflexia, sympathetic preganglionic neuron, ventral lateral medulla. 20042007 $44,000 $132,000 I Parkash, Ratika; Sapp, John L; Basta, Magdy N; Gardner, Martin J; Tang, Anthony SL; Wells, George A Dalhousie University Abnormalities in rhythm in the cardiac resynchronization/ defibrillation in advanced heart failure trial. Heart failure, implantable defibrillator, cardiac resynchronization, ventricular arrhythmias, sudden death. 20062009 $50,000 $50,000 I, II, III, IV Themes I: Basic Biomedical Thèmes I : Biomédicale fondamentale $ cumulatif reçu en 2007 II: Clinical II : Clinique III: Health Services/Systems III : Services et systèmes de santé IV: Population Health IV : Santé de la population 125 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 06-07 $ Cumulative $ Theme to 2007 Thème Principal Investigator Institute of Principal Project Keywords Term and Co-Investigator(s) Investigator Projet Mots-clés Durée Chercheur principal et Institut du chercheur co-chercheur(s) principal Pasumarthi, Kishore Babu S Dalhousie University Regulation of cardiomyocyte cell cycle by D-type cyclins. Cardiomyocyte cell cycle, myocardial repair, gene transfer, transgenic mice, protein-protein interactions. 20042007 $50,000 $150,000 I Robertson, Harold A; Currie, R William Dalhousie University Stroke genomics identification of the temporal and spatial patterns of gene expression in the early hours following cerebral ischemia. Stroke, DNA microarray, gene expression profiling, neuroprotection. 20042007 $50,000 $150,000 I Sapp, John L; Horacek, B Milan Queen Elizabeth II Health Sciences Centre Electrocardiographic mapping to aid ablation of scar-related ventricular tachycardia. Clinical cardiac electrophysiology, biomedical engineering. 20042007 $47,623 $143,835 II $ cumulatif reçu en 2007 *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 126 APPENDIX Annexe D RESEARCH CHAIRS AND PROFESSORSHIPS CHAIRES DE RECHERCHE ET POSTES DE PROFESSEURS In 2006-2007 Dr. Henry Duff (University of Calgary) was the Heart and Stroke Foundation of Alberta, NWT & Nunavut Chair in Cardiovascular Research. Photo by: Trudie Lee En 2006-2007, Dr Henry Duff (Université de Calgary) était titulaire de la Chaire de recherche cardiovasculaire de la Fondation des maladies du cœur de l’Alberta, des T.-N.-O. et du Nunavut. Photo par : Trudie Lee Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Research Chairs and Professorships | Chaires de recherche et postes de professeurs Research Chairs Type Foundation 2006/2007 Value Chaires de recherche Type Fondation Montant 2006-2007 Dr. Christopher Buller, University of British Columbia Cardiology/Cardiologie HSFBCY/FMCCB et Y $160,000 Dr. Yu Tian Wang, University of British Columbia Stroke/AVC HSFBCY/FMCCB et Y $110,000 Dr. Henry Duff, University of Calgary Cardiology/Cardiologie HSFA/FMCA $173,462 Dr. Heather Arthur, McMaster University Cardiac Nursing/Soins infirmiers en cardiologie HSFO/FMCO $102,489 Dr. Fred Keeley, Hospital for Sick Children Cardiology/Cardiologie HSFO/FMCO $138,777 Dr. Peter Liu, Toronto Hospital/University of Toronto Cardiology/Cardiologie HSFO/FMCO $77,450 Dr. Brian Rutt, Robarts Research Institute Cardiology/Cardiologie HSFO/FMCO $159,046 Dr. Jeffery Weitz, Hamilton Civic Hospitals Research Centre Cardiology/Cardiologie HSFO/FMCO $77,811 Dr. Salim Yusuf, McMaster University Cardiology/Cardiologie HSFO/FMCO $74,545 Professorships Type Foundation Postes de professeurs Type Fondation Dr. Philip Teal, University of British Columbia Stroke/AVC HSFBCY/FMCCB et Y $70,000 Dr. Ken Butcher, University of Alberta Stroke/AVC HSFA/FMCA $80,000 Dr. Micheal Hill, University of Calgary Stroke/AVC HSFA/FMCA $80,000 Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from other sources. Généralement, les chaires de recherche et les postes de professeurs sont financés par la contribution des fondations provinciales mentionnées ainsi que par des sommes provenant d’autres sources. 128 APPENDIX Annexe E OTHER PROVINCIAL INITIATIVES AUTRES INITIATIVES PROVINCIALES The Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source is a powerful new tool for the imaging, study and treatment of disease. This facility is funded through a broad-based partnership of supporters, including the Heart and Stroke Foundation of Saskatchewan. Photo by: Canadian Light Source Inc., University of Saskatchewan. Le faisceau d’imagerie et de traitement biomédical du Centre canadien de rayonnement synchrotron est un puissant outil d’imagerie, d’étude et de traitement des maladies. Ces installations sont financées par un vaste partenariat de supporteurs, dont la Fondation des maladies du cœur de la Saskatchewan. Photo par le Centre canadien de rayonnement synchrotron inc., Université de la Saskatchewan. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 British Columbia/Yukon Colombie-Britannique / Yukon Special Initiative: CardioSHARE - Cardiovascular Semantic Health and Research Environment Principal Investigators: Dr. Bruce McManus and Dr. Mark Wilkinson Providence Heart + Lung Institute $360,000 over 2 years (March 1, 2007 to Feb. 28, 2009) to develop a data search, classification, and management system for ischemic heart disease. Initiative spéciale : CardioSHARE - Environnement de santé et de recherche cardiovasculaires sémantiques Chercheurs principaux : Dr Bruce McManus et Dr Mark Wilkinson Institut Providence Heart + Lung 360 000 dollars sur deux ans (1er mars 2007 au 28 février 2009) afin de développer un système de recherche, de classification et de gestion des données sur les maladies cardiovasculaires ischémiques. Alberta/Northwest Territories/Nunavut Alberta / Territoires du Nord-Ouest / Nunavut Young Investigator Travel Awards | Bourses de déplacement pour jeune chercheur Awardee Institute of Project Keywords Term Récipiendaire Institut Projet Mots-clés Durée Davidge, Sandra T University of Alberta Preeclampsia: circulating factors and endothelial cell dysfunction. Preeclampsia, endothelium, oxidative stress, nitric oxide, matrix, metalloproteinase. 20062007 $5,000 $5,000 Seubert, John M University of Alberta Role of eicosanoids in heart function Eicosanoids, cytochrome P450 epoxygenases, and injury. ischemia-reperfusion injury, potassium channels, natriuretic peptides. 20062007 $5,000 $5,000 Tyberg, John V University of Calgary New hemodynamic approaches to the pulmonary circulation. Windkessel, wave intensity analysis, pulmonary hemodynamics, pulmonary hypertension, doppler echocardiography. 20062007 $5,000 $5,000 Waisman, David M University of Calgary Regulation of fibrinolysis by annexin II tetramer. Annexin, antiphospholipid syndrome, plasmin, plasminogen, endotheliium. 20062007 $5,000 $5,000 Saskatchewan Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source HSFS annual commitment is $100,000 for five years from 2005 to 2009. Manitoba R.E. Beamish Award An award of excellence in cardiac research given to the highest rated HSFM GIA recipient in honour of Dr. Robert Beamish. 2006-2007 Recipient: Dr. Marc Del Bigio (University of Manitoba) $10,000 130 06-07 $ Total $* Saskatchewan Le faisceau d’imagerie et de traitement biomédical du Centre canadien de rayonnement synchrotron L’engagement annuel de 100 000 $ de la FMCS pour une durée de cinq ans, soit de 2005 à 2009. Manitoba Prix R.E. Beamish Prix d’excellence en recherche cardiovasculaire remis au lauréat de subvention de la FMCM ayant obtenu la plus haute note, en hommage au Dr Robert Beamish. Lauréat 2006-2007 Dr Marc Del Bigio (Université du Manitoba) 10 000 $ Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Ontario | Ontario Group/Program Grants | Subventions de groupe et de programme Principal Institute of Principal Project Co-Investigator(s) Term Projet Co-chercheur(s) Durée 06-07 $ Total $* $500,000 Investigator Investigator Chercheur Institut du principal chercheur principal Floras, John S Mount Sinai Hospital Multidisciplinary group for the investigation and therapy of human cardiovascular disease. Newton, Gary E; Parker, John D; Bradley, T Douglas; Chauhan, Vijay S 20032008 $100,000 Huff, Murray W Robarts Research Institute Cellular programs and responses in atherosclerosis. Ferguson, Stephen G; Hegele, Robert A; Pickering, J Geoffrey 20062011 $250,000 $1,250,000 Karmazyn, Morris University of Western Ontario A multidisciplinary, integrative approach towards the study of heart failure. Chakrabarti, Subrata; Chidiac, Peter; Feng, Qingping; Jones, Douglas L; Narayanan, Njanoor; Sims, Stephen M 20022007 $240,000 $1,200,000 Langille, B Lowell Toronto General Hospital Cell biology of atherosclerosis. Bendeck, Michelle P; Courtman, David W; Cybulsky, Myron I; Gotlieb, Avrum I; Husain, Mansoor; Marsden, Philip A; Stewart, Duncan J; Strauss, Bradley H; Ward, Michael E; Heximer, Scott P 20052010 $250,000 $1,249,915 Leenen, Frans HH University of Ottawa Heart Institute Molecular and genetic bases for coronary artery disease and the progression to heart failure. O’Brien, Edward R; Tesson, Frederique; Tuana, Balwant S; Whitman, Stewart C 20032008 $150,000 Wells, Philip S University of Ottawa Thrombophilia: from bench to bedside to health economics and policy. Rodger, Marc A; Walker, Mark; Gagnon, France 20042009 $250,000 $1,250,000 $750,000 Health Behaviour Research Initiative | Initiative de la recherche sur la santé et les habitudes de vie Principal Institute of Principal Investigator Investigator Chercheur Institut du principal chercheur principal Allison, Kenneth R University of Toronto Project Co-Investigator(s) Term Projet Co-chercheur(s) Durée Physical activity promotion among youth. Goodman, Jack M; Adlaf, Edward M; Dwyer, John JM 20012007 06-07 $ Total $* $209,242 $1,081,184 131 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Stroke Rehabilitation | Réadaptation après un AVC Principal Institute of Principal Project Co-Investigator(s) Term Investigator Investigator Projet Co-chercheur(s) Durée Chercheur Institut du principal chercheur principal Brooks, Dina University of Toronto Cardic rehabilitation after stroke. Black, Sandra E; McIlroy, William E; Sahlas, Demetrios James; Oh, Paul; Bayley, Mark T; Richardson, Denyse L 20062009 $73,940 $208,276 Brouwer, Brenda Queen’s University Client-centred ‘tune-ups’: Do they enhance physical capacity, mobility function and community reintegration in stroke survivors? Garland, S Jayne; Bryant, Dianne M; Connelly, Denise M; Maly, Monica R; Minnes, Patricia M; MacIntyre, Norma J; Pelland, Lucie C 20062009 $227,473 $680,736 Huijbregts, Maria PJ Baycrest Centre for Geriatric Care Filling the community programStreiner, David L; Cameron, Jill ming gap in northern Ontario: I; Taylor, Denise M; Kagan, Aura; Telehealth dissemination of a stroke McEwen, Sara self-management program. 20052008 $161,945 $407,595 Popovic, Milos R University of Toronto Functional electrical stimulation-assisted walking: enhancement of voluntary walking function among persons with severe hemiplegia post stroke. 20062008 $177,681 $309,946 Salbach, Nancy M; Thabane, Lehana; Verrier, Mary C; Richardson, Denyse L; Giangregorio, Lora M 06-07 $ Total $* Age 45+ with Elevated Systolic Blood Pressure | Tension artérielle systolique élevée chez les 45 ans et plus Principal Institute of Principal Project Co-Investigator(s) Term Projet Co-chercheur(s) Durée 06-07 $ Total $* Investigator Investigator Chercheur Institut du principal chercheur principal Fayad, Ashraf A University of Ottawa Peri-operative myocardial ischemia in isolated systolic hypertension (PROMISE). Ruddy, Terrence D; Yang, Homer; Wells, George A; Watters, James M 20062008 $177,203 $359,928 Logan, Alexander G Mount Sinai Hospital Self-monitoring of blood pressure in primary care in older (45+ years) diabetic patients with uncontrolled systolic hypertension. Irvine, Jane M; McIsaac, Warren J; Feig, Denice; Easty, Anthony C; Cafazzo, Joseph A; Rossos, Peter G; Davis-Halifax, Nancy; Kelly, Catherine M; Parkes, Robert K 20062009 $205,320 $629,619 Myers, Martin G Sunnybrook Health Sciences Centre Automated office blood pressure measurement. Tobe, Sheldon W; Kaczorowski, Janusz; Godwin, Marshall S; Kiss, Alexander J; Dawes, Martin 20052009 $374,792 $1,507,534 Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Interim Director: Dr. Mansoor Husain, University of Toronto HSFO contribution: $6 million This research investment represents commitments from previous funding years involving research activity that carries into 2006/2007. 132 Centre d’excellence en recherche cardiovasculaire Heart and Stroke/Richard Lewar Directeur par intérim : Dr Mansoor Husain, Université de Toronto Contribution de la FMCO : 6 million $ L’investissement en recherche représente des engagements pris au cours d’exercices précédents envers un projet de recherche qui se poursuit en 2006-2007. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Heart and Stroke Foundation Centre for Stroke Recovery Co-directors: Dr. Antoine M. Hakim, Ottawa Health Research Institute Dr. Sandra Black, Sunnybrook and Women’s College Health Science Centre Dr. Don Stuss, Baycrest Centre for Geriatric Care HSFO annual commitment of $649,000 for ten years from 2002 to 2011, plus $997,000 capital campaign contribution in 2006/2007. Centre de réadaptation d’AVC de la Fondation des maladies du cœur Co-directeurs : Dr Antoine M. Hakim, Institut de recherche en santé d’Ottawa Dre Sandra Black, Sunnybrook and Women’s College Health Science Centre Dr Don Stuss, Baycrest Centre for Geriatric Care Engagement annuel de 649 000 dollars sur 10 ans de la FMCO, de 2002 à 2011, plus une contribution de 997 000 dollars de capitalisation en 2006-2007. Quebec Québec Awards for excellence Awards for excellence highlighting the outstanding contribution of researchers. Prix d’excellence Prix d’excellence mettant en lumière la contribution remarquable des chercheurs. These awards enhance the grants allocated to these researchers in 2006-2007: Ces prix viennent bonifier la subvention accordée à ces chercheurs en 2006-2007 : The 4th International Conference on Preventive Cardiology Award Dr. Philippe Pibarot (Hôpital Laval) $20,000 Le prix de la 4e Conférence internationale de cardiologie préventive Dr Philippe Pibarot (Hôpital Laval) 20 000 $ The Jonathan Ballon Award Dr. Mohsen Agharazii (Hôtel-Dieu de Québec) $10,000 Le prix Jonathan Ballon Dr Mohsen Agharazii (Hôtel-Dieu de Québec) 10 000 $ The John J. Day Award Dr. William S. Powell (McGill University) $10,000 Le prix John J. Day Dr William S. Powell (Université McGill) 10 000 $ The RBC Royal Bank Award Dr. Sydney B. Miller (Concordia University) $10,000 Le prix RBC Banque Royale Dr Sydney B. Miller (Université Concordia) 10 000 $ The Desjardins Financial Security Award Dr. Lorraine E. Chalifour (Sir Mortimer B. Davis - Jewish General Hospital) $10,000 Le prix Desjardins Sécurité financière Dre Lorraine E. Chalifour (Hôpital général juif Sir Mortimer B. Davis) 10 000 $ The Alfred B. Grossman Award of the EJLB Foundation Dr. Michel Bouvier (Université de Montréal ) $5,000 Le prix Alfred B. Grossman de la Fondation EJLB Dr Michel Bouvier (Université de Montréal ) 5 000 $ The Buckingham Lions Club Award in memory of Robert Champagne Dr. Jacques Genest Jr (Royal Victoria Hospital - MUHC) $5,000 Le prix Club Lions de Buckingham en mémoire de Robert Champagne Dr Jacques Genest Jr (Hôpital Royal Victoria - CUSM) 5 000 $ The Birks Family Foundation Award Dr. Benoît Drolet (Hôpital Laval) $5,000 Le prix de la Fondation de la famille Birks Dr Benoît Drolet (Hôpital Laval) 5 000 $ The Pfizer Canada Award Dr. Louise Brissette (Université du Québec à Montréal) $5,000 Le prix Pfizer Canada Dre Louise Brissette (Université du Québec à Montréal) 5 000 $ The Pratt & Whitney Canada Award Dr. M’hamed Bentourkia (Université de Sherbrooke) $5,000 Dr. Nicolas Noiseux (CHUM - Hôtel-Dieu) $5,000 Le prix Pratt & Whitney Canada Dr M’hamed Bentourkia (Université de Sherbrooke) 5 000 $ Dr Nicolas Noiseux (CHUM - Hôtel-Dieu) 5 000 $ 133 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 The award of Excellence in Memory of Claire Laforest and Rosario Boucher Dr. Jolanta Gutkowska (CHUM - Hôtel-Dieu) $5,000 Le prix d’excellence à la mémoire de Mme Claire Laforest et M. Rosario Boucher Dre Jolanta Gutkowska (CHUM - Hôtel-Dieu) 5 000 $ The sanofi-aventis Award Dr. Julie L. Lavoie (CHUM - Hôtel-Dieu) $5,000 Le prix Sanofi-aventis Dre Julie L. Lavoie (CHUM - Hôtel-Dieu) 5 000 $ Training bursaries for PhD students in Cardiovascular and Stroke research Partnership between the Fonds de la recherche en santé du Québec (FRSQ), the Réseau en santé cardiovasculaire (RSCV) and the Heart and Stroke Foundation of Québec (HSFQ). Bourses de formation à des étudiants de 3e cycle en recherche cardiovasculaire et vasculaire cérébrale. Partenariat entre le Fonds de la recherche en santé du Québec (FRSQ), le Réseau en santé cardiovasculaire (RSCV) et la Fondation des maladies du cœur du Québec (FMCQ). The partners offer Training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart and Stroke Foundation of Québec (HSFQ). Les partenaires offrent des bourses d’aide à la formation pour le soutien d’étudiants au doctorat, travaillant avec des chercheurs ayant obtenu une subvention de la Fondation des maladies du cœur du Québec. In 2006-2007, 2 bursaries were given: Pedro Geraldes (Dr. Jean-François Tanguay, Montreal Heart Institute) $20,000 Carl Bolduc (Dr. Jonny St-Amand, Université Laval) $20,000 En 2006-2007, deux bourses ont été offertes : Pedro Geraldes (Dr. Jean-François Tanguay, Institut de Cardiologie de Montréal) 20 000 $ Carl Bolduc (Dr. Jonny St-Amand, Université Laval) 20 000 $ Nova Scotia Nouvelle-Écosse Gregory Ferrier Award An award of excellence in research given to the highest rated HSFNS GIA recipient in honour of Dr. Greg Ferrier. 2006-2007 Recipient: Dr. Ratika Parkash (Dalhousie University) $5,000 Prix Gregory Ferrier Prix d’excellence remis au lauréat de subvention de la FMCNÉ ayant obtenu la plus haute note, en hommage au Dr Greg Ferrier. Lauréat 2006-2007 : Dre Ratika Parkash (Université Dalhousie) 5 000 $ Prince Edward Island | Île-du-Prince-Édouard Project Grant | Subvention de projet Principal Investigator and Co-Investigator(s) Institute of Principal Investigator Project Keywords Term Chercheur principal et co-chercheur(s) Institut du chercheur principal Projet Mots-clés Durée Sweeney-Nixon, Marva University of Prince Edward Island Blueberry assay project. *Amount may change depending on circumstances *Le montant peut changer selon les cirsconstances 134 2004-2009 06-07 $ Total $• $10,000 $50,000 APPENDIX Annexe F RESEARCH COMMITTEE MEMBERS MEMBRES DU COMITÉ DE LA RECHERCHE Dr. Grant Pierce (St. Boniface Hospital Research Centre) was the 2006-2007 Chair of the Heart and Stroke Foundation of Canada Scientific Review Committee. Dr Grant Pierce (Centre de recherche de l’Hôpital Saint-Boniface) était président du Comité d’examen scientifique de la Fondation des maladies du cœur en 2006-2007. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 2006-2007 Research Policy and Planning Advisory Committee Comité consultatif sur les politiques et la planification de la recherche 2006-2007 Carolyn Brooks, Chair Robert Côté, MD, Vice-Chair Montreal General Hospital Roy Cameron, PhD University of Waterloo Karen Chad, PhD University of Saskatchewan David Fedida, MD, PhD, University of British Columbia Danielle Groleau, PhD Jewish General Hospital John Hinds Canadian Community Newspapers Association Carol Jillings, PhD Ex-Officio Chair, Heart and Stroke Foundation of Canada Board of Directors Marilyn Mackay-Lyons, PhD Dalhousie University Grant Pierce, PhD Chair, Scientific Review Committee St Boniface Hospital Research Centre Margaret L. Rand, PhD Hospital for Sick Children David Shragge, MD Misericordia Community Hospital Lisa Southern Labour Relations Board of British Columbia Carolyn Brooks, présidente Robert Côté, M.D., vice-président Hôpital général de Montréal Roy Cameron, Ph.D. Université de Waterloo Karen Chad, Ph.D. Université de la Saskatchewan David Fedida, M.D., Ph.D., Université de la Colombie-Britannique Danielle Groleau, Ph.D. Hôpital général juif John Hinds Canadian Community Newspapers Association Carol Jillings, Ph.D. Présidente ex officio, conseil d’administration de la Fondation des maladies du cœur du Canada Marilyn Mackay-Lyons, Ph.D. Université Dalhousie Grant Pierce, Ph.D. Président, Comité d’examen scientifique Centre de recherches de l’Hôpital Saint-Boniface Margaret L. Rand, Ph.D. Hospital for Sick Children David Shragge, M.D. Hôpital communautaire Misericordia Lisa Southern Commission des relations de travail de la Colombie-Britannique 136 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 2006-2007 Scientific Review Committee Leadership Direction des Comités d’examen scientifique 2006-2007 Grant Pierce, PhD, Chair St. Boniface Hospital Research Centre Heather Arthur, PhD, Vice Chair McMaster University Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials/health services research John Parker, MD, Chair Mount Sinai Hospital William Ghali, MD, Deputy Chair University of Calgary Integrative studies: genetic manipulations/imaging/ bioengineering Sheldon Magder, MD, Chair Royal Victoria Hospital Mansoor Husain, MD, Deputy Chair Toronto General Hospital Basic science stroke/neurophysiology/neuroregulation James Peeling, PhD, Chair University of Manitoba Phyllis Paterson, PhD, Deputy Chair University of Saskatchewan Grant Pierce, Ph.D., président Centre de recherches de l’Hôpital Saint-Boniface Heather Arthur, Ph.D., vice-président Université McMaster Recherche clinique cardiovasculaire et vasculaire cérébrale; études mécanistes et essais cliniques / recherche sur les services de santé John Parker, M.D., président Hôpital Mont Sinai William Ghali, M.D., vice-président Université de Calgary Études intégratives; manipulations génétiques / imagerie / bio-ingénierie Sheldon Magder, M.D., président Hôpital Royal Victoria Mansoor Husain, M.D., vice-président Hôpital général de Toronto Recherche fondamentale sur les AVC / neurophysiologie / neurorégulation James Peeling, Ph.D., président Université du Manitoba Cellular biochemistry, pharmacology and electrophysiology A Geoffrey Pickering, MD, PhD, Chair London Health Sciences Centre Phyllis Paterson, Ph.D., vice-président Université de Saskatchewan Elissavet Kardami, PhD, Deputy Chair University of Manitoba Biochimie cellulaire, pharmacologie et électrophysiologie A Geoffrey Pickering, M.D., Ph.D., président Centre des sciences de la santé de London Cellular biochemistry, pharmacology and electrophysiology B David Fedida, MD, PhD, Chair University of British Columbia Elissavet Kardami, Ph.D., vice-présidente Université du Manitoba Rhian Touyz, MD, PhD, Deputy Chair University of Ottawa Biochimie cellulaire, pharmacologie et électrophysiologie B David Fedida, M.D., président Université de la Colombie-Britannique Molecular basis of cardiac and vascular function Timothy Lee, PhD, Chair Dalhousie University Rhian Touyz, M.D., Ph.D., vice-président Université d’Ottawa 137 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 Kelly McNagny, PhD, Deputy Chair University of British Columbia Fondements moléculaires de la fonction cardiaque et vasculaire Timothy Lee, Ph.D., président Université Dalhousie Thrombosis/lipid and lipoproteins/fundamental nutrition research Mark Hatton, PhD, Chair McMaster University Richard Lehner, PhD, Deputy Chair University of Alberta Behavioural research/health psychology/rehabilitation/ population health Blaine Ditto, PhD, Chair McGill University Robert D. Reid, PhD, Deputy Chair University of Ottawa Heart Institute Senior Personnel (New Investigator/Career Investigator/ Visiting Scientist) Grant Pierce, PhD, Chair St. Boniface Hospital Research Centre Heather Arthur, PhD, Deputy Chair McMaster University Doctoral Research Awards Laszlo Bajzar, PhD, Chair University of Alberta Research Fellowships Andrew Krahn, MD, Chair London Health Sciences Centre Kelly McNagny, Ph.D., vice-président Université de la Colombie-Britannique Thrombose / lipides et lipoprotéines / recherche fondamentale sur la nutrition Mark Hatton, Ph.D., président Université McMaster Richard Lehner, Ph.D., vice-président Université de l’Alberta Recherche comportementale / psychologie de la santé / réadaptation / santé des populations Blaine Ditto, Ph.D., président Université McGill Robert D. Reid, Ph.D., vice-président Institut de cardiologie de l’Université d’Ottawa Personnel de direction (Jeune chercheur / chercheur de carrière / chercheur invité) Grant Pierce, Ph.D., président Centre de recherches de l’Hôpital Saint-Boniface Heather Arthur, Ph.D., vice-présidente Université McMaster Bourses de recherche doctorale Laszlo Bajzar, Ph.D., président Université de l’Alberta Bourses de recherche Andrew Krahn, M.D., président Centre des sciences de la santé de London 138 Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 2006-2007 Provincial Research Advisory Committee Chairs 2006-2007 Présidents des comités consultatifs de recherche provinciaux Heart and Stroke Foundation of British Columbia and Yukon Research Advisory Committee Glen F. Tibbits, PhD, Chair Simon Fraser University Heart and Stroke Foundation of Alberta, Northwest Territories and Nunavut Research and Medical Advisory Committee Henry J Duff, MD, Chair University of Calgary Heart and Stroke Foundation of Saskatchewan Ad Hoc Research Advisory Committee Douglas C. Hodson, QC, Chair MacPherson Leslie & Tyerman LLP Heart and Stroke Foundation of Manitoba Research Advisory Committee Patrick C. Choy, PhD, Chair University of Manitoba Heart and Stroke Foundation of Ontario Grant Allocation Sub-Committee Philip W. Connelly, PhD, Chair St. Michael’s Hospital Heart and Stroke Foundation of Ontario Research Committee Ross D. Feldman, MD, Chair Robarts Research Institute Comité scientifique de la Fondation des maladies du coeur du Québec Pédro D’Orléans-Juste, PhD, Président Université de Sherbrooke Heart and Stroke Foundation of New Brunswick Medical Advisory Committee Carolyn Baer, MD, Chair South East Regional Health Authority Heart and Stroke Foundation of Nova Scotia Scientific Advisory Committee Roger S. McLeod, PhD, Chair Dalhousie University Comité consultatif de la recherche de la Fondation des maladies du cœur de Colombie-Britannique et du Yukon Glen F. Tibbits, Ph.D., président Université Simon Fraser Comité consultatif scientifique et médical de la Fondation des maladies du cœur de l’Alberta, des Territoires du Nord-Ouest et du Nunavut Henry J Duff, M.D., président Université de Calgary Comité consultatif ad hoc sur la recherche de la Fondation des maladies du cœur de la Saskatchewan Douglas C. Hodson, QC, président MacPherson Leslie & Tyerman LLP Comité consultatif de la recherche de la Fondation des maladies du cœur du Manitoba Patrick C. Choy, Ph.D., président Université du Manitoba Sous-comité d’attribution des subventions de la Fondation des maladies du cœur de l’Ontario Philip W. Connelly, Ph.D., président Hôpital St. Michael’s Comité de recherche de la Fondation des maladies du cœur de l’Ontario Ross D. Feldman, M.D., président Institut de recherche Robarts Comité scientifique de la Fondation des maladies du cœur du Québec Pedro D’Orléans-Juste, Ph.D., président Université de Sherbrooke Comité consultatif médical de la Fondation des maladies du cœur du Nouveau-Brunswick Carolyn Baer, M.D., présidente Direction régionale de la santé du Sud-Ouest Comité consultatif scientifique de la Fondation des maladies du cœur de la Nouvelle-Écosse Roger S. McLeod, Ph.D., président Université Dalhousie 139 APPENDIX Annexe G DEFINITION OF HEALTH RESEARCH THEMES DÉFINITION DES THÈMES DE LA RECHERCHE EN SANTÉ Dr. Patti-Jean Naylor (University of Victoria) and Dr. Heather McKay (University of British Columbia) were recipients in 2006-2007 of an award funded through the Federation Research Fund’s Childhood Obesity Operating Grants 2005 initiative, titled Evaluating the effectiveness of the dissemination of Action Schools! BC: a socio-ecological intervention to increase physical activity and healthy eating in school children. Dre Patti-Jean Naylor (Université de Victoria) et Dre Heather McKay (Université de la Colombie-Britannique) étaient lauréates 2006-2007 d’une bourse financée dans le cadre de l’initiative Subventions de fonctionnement en obésité infantile 2005 du Fonds de recherche de la Fédération, pour leur projet intitulé Evaluating the effectiveness of the dissemination of Action Schools! BC: a socio-ecological intervention to increase physical activity and healthy eating in school children. Heart and Stroke Foundation | Research Report 2006-2007 Fondation des maladies du cœur | Rapport de recherche 2006-2007 The four themes of health research as defined by the Michael Smith Foundation for Health Research are: Les quatre thèmes de la recherche en soins de santé, tels que définis par la Fondation Michael Smith pour la recherche en soins de santé, sont : I. Basic Biomedical Research with the goal of understanding normal and abnormal human function, at the molecular, cellular, organ system, and whole body levels, including the development of tools and techniques to be applied for this purpose; developing new therapies or devices which improve health or the quality of life of individuals, up to the point where they are tested on human subjects. Studies on human subjects that do not have a diagnostic or therapeutic orientation. II. Clinical Research with the goal of improving the diagnosis and treatment (including rehabilitation and palliation) of disease and injury; improving the health and quality of life of individuals as they pass through normal life stages. Research on, or for the treatment of, patients. III. Health Services/Systems Research with the goal of improving the efficiency and effectiveness of health professionals and the health care system, through changes to practice and policy. Health services research is a multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies, and personal behaviours affect access to health care, the quality and cost of health care, and ultimately our health and well-being. IV. Population Health Research with the goal of improving the health of the Canadian population, or of defined sub-populations, through a better understanding of the ways in which social, cultural, environmental, occupational, and economic factors determine status. 142 I. La recherche biomédicale fondamentale Recherche qui a pour but de comprendre le fonctionnement normal et anormal de l’organisme humain aux niveaux moléculaire, cellulaire, organique ou de l’ensemble du corps, incluant la création d’outils et de techniques à cet effet, ainsi que le développement de nouveaux traitements ou dispositifs qui améliorent la santé et la qualité de vie, jusqu’à leur application sur des sujets humains. Ces études portant sur des sujets humains sont sans but diagnostique ou thérapeutique. II. La recherche clinique Recherche qui a pour but d’améliorer le diagnostic et le traitement – incluant la réadaptation et les soins palliatifs – de maladies ou de blessures, ainsi que la santé et la qualité de vie des personnes qui traversent des étapes normales de la vie. Recherche sur le traitement lui-même ou les moyens de traiter les patients. III. Les systèmes et services de santé Recherche qui a pour but d’améliorer l’efficacité des professionnels et des systèmes de santé en agissant sur la politique et la pratique professionnelle. La recherche menée par les services de santé est un domaine multidisciplinaire d’investigation scientifique qui étudie l’impact des facteurs sociaux, des systèmes de financement, des structures et des procédés organisationnels, des technologies de la santé et des comportements personnels sur l’accès aux soins de santé, sur leur qualité et leurs coûts, et enfin, sur notre santé et notre bien-être à tous. IV. La santé de la population Recherche qui a pour but d’améliorer la santé de la population canadienne, ou de sous-groupes de population spécifiques, grâce à une meilleure compréhension de la façon dont les facteurs sociaux, culturels, environnementaux, occupationnels et économiques définissent le statut des personnes. Millions of Canadians will develop some form of heart disease or stroke over their lifetime - and some at a much too early age. As a leading funder of heart and stroke research in Canada, the Heart and Stroke Foundation continues to find the answers that lead to earlier diagnoses, better treatments and new insights into how to prevent and manage these diseases. To protect your health and the health of those you love, the Foundation also provides the most up-to-date healthy living information to Canadians, based on the most current, evidence-based research. Des millions de Canadiens et de Canadiennes souffriront d’une forme ou d’une autre de maladie du cœur ou d’accident vasculaire cérébral (AVC) au cours de leur vie, et certains à un âge beaucoup trop précoce. Étant l’un des principaux bailleurs de fonds de la recherche cardiovasculaire et vasculaire cérébrale au pays, la Fondation des maladies du cœur continue de chercher des réponses menant à des diagnostics plus précoces, à de meilleurs traitements et à de nouvelles avenues de prévention et de contrôle de ces maladies. Afin de protéger votre santé et celle de vos personnes chères, la Fondation offre aux Canadiens et aux Canadiennes l’information la plus récente sur les modes de vie, à partir des dernières découvertes scientifiques. To find more information about heart disease, stroke, how to live a healthy life, as well as how you can offer much needed support in your community, visit www.heartandstroke.ca or call 1-888-HSF-INFO (1-888-473-4636) Pour de plus amples renseignements sur les modes de vie sains, les maladies du cœur et les AVC offerts par la Fondation des maladies du cœur, et pour apprendre comment vous pouvez offrir un soutien essentiel dans votre collectivité, visitez le site www.fmcoeur.ca ou faites le 1-888-473-INFO (1-888-473-4636)