Heart and Stroke Foundation Research Report 2007-2008

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Heart and Stroke Foundation Research Report 2007-2008
Research Report | RAPPORT DE RECHERCHE
2006-2007
www.hsf.ca/research
Cover Photo: Dr. James M. Christenson (British Columbia Ambulance Service) works with a team funded in 2006-2007 through an award
titled Proposal to create a Canadian collaborative RCC. The award is part of the Federation Research Fund’s Resuscitation Outcomes
Consortium 2004 initiative.
Photo de la page couverture : Dr James M. Christenson (Service ambulancier de la Colombie-Britannique) travaille avec une équipe
établie en 2006-2007 grâce à une bourse de recherche intitulée Proposal to create a Canadian collaborative RCC. La bourse fait partie
du Fonds de recherche de la Fédération dans le cadre de l’initiative Consortium sur les retombées de la réanimation 2004.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
MISSION
MISSION
The Heart and Stroke Foundation, a
volunteer-based health charity, leads
in eliminating heart disease and stroke
and reducing their impact through
the advancement of research and its
application, the promotion of healthy
living, and advocacy.
Organisme bénévole de bienfaisance
en santé, la Fondation des maladies du
cœur mène la lutte vers l’élimination
des maladies du cœur et des accidents
vasculaires cérébraux (AVC), en
contribuant activement à l’avancement
de la recherche et sa mise en application,
à la promotion de modes de vie sains et
à la représentation auprès des instances
responsables des politiques de santé.
The Heart and Stroke Foundation is a federation of 10 provincial
Foundations, led and supported by a force of more than
140,000 volunteers.
For more than 50 years, Canadians have looked to the Heart and
Stroke Foundation to fund research that will reduce their risk of
cardio- and cerebrovascular disease and improve the quality of
their lives. The Foundation has met that challenge. In the last 50
years, the Heart and Stroke Foundation has invested more than
$1 billion in heart and stroke research.
The mortality rate from heart disease and stroke has decreased
in Canada by 70% since 1952, thanks in large part to our research.
However, there is still so much more to do. More than 50,000
strokes and 75,000 heart attacks occur in Canada every year. At
least one in three deaths annually is due to heart disease and
stroke. Cardio- and cerebrovascular disease remains the leading
cause of death in Canada and world-wide.
In 2006-2007, the Heart and Stroke Foundation invested over
$50 million in peer-reviewed research at medical institutes,
universities, and hospitals across the country. Our shared goal:
to eliminate heart disease and stroke and improve the quality
of life for thousands of Canadians affected by these conditions.
Every research project highlighted in this report contributes to
achieving this vision.
La Fondation des maladies du cœur est une fédération
regroupant 10 fondations provinciales dirigées et appuyées
par une force de plus de 140 000 bénévoles.
Depuis plus de 50 ans, les Canadiens et les Canadiennes se
tournent vers la Fondation des maladies du cœur afin de financer
la recherche visant à réduire les risques associés aux maladies du
cœur et aux accidents vasculaires cérébraux (AVC) et à améliorer
leur qualité de vie. La Fondation a relevé ce défi. Au cours des
50 dernières années, la Fondation des maladies du cœur a investi
plus d’un milliard de dollars en recherche sur les maladies du
cœur et les AVC.
Le taux de mortalité attribuable aux maladies du cœur et aux
AVC a diminué de 70 % au Canada depuis 1952, en grande
partie grâce à nos recherches. Il reste cependant encore
beaucoup à faire. Chaque année, plus de 50 000 AVC et 75 000
crises cardiaques surviennent encore au pays et au moins un
décès sur trois est attribuable aux maladies du cœur et aux AVC.
Les maladies du cœur et les AVC demeurent la principale cause
de mortalité au Canada et dans le monde entier.
En 2006-2007, la Fondation des maladies du cœur a investi plus
de 50 millions de dollars dans la recherche évaluée par les pairs,
effectuée dans les instituts médicaux, les universités et les
centres hospitaliers du pays. Notre objectif consiste à éliminer
les maladies du cœur et les AVC et à améliorer la qualité de
vie des milliers de Canadiens et de Canadiennes qui en sont
affectés. Chaque projet de recherche mentionné dans ce
rapport 00contribue à la poursuite de cette vision.
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Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
TABLE OF CONTENTS
TABLE DES MATIÈRES
MESSAGE FROM THE CHAIR, RESEARCH POLICY AND
MESSAGE DU PRÉSIDENT DU COMITÉ CONSULTATIF SUR
PLANNING ADVISORY COMMITTEE........................................ 1
LES POLITIQUES ET LA PLANIFICATION DE LA RECHERCHE... 1
1PURPOSE AND SCOPE....................................................... 2
1OBJECTIFS ET PORTÉE...................................................... 2
2SUMMARY TABLES.............................................................. 3
2TABLEAUX SOMMAIRES..................................................... 4
3
RESEARCH FUNDING OVERVIEW.................................... 8
3SURVOL DU FINANCEMENT DE LA RECHERCHE......... 8
3.1
Research Roles.......................................................... 8
3.1
3.2Scientific Review Process......................................... 8
3.2Processus d’examen scientifique............................ 8
3.3
Research Enterprise Components.......................... 9
3.3
3.4
Investments across Health Research Themes..... 10
3.4Investissements dans les quatre thèmes de
4
2006-2007 RESEARCH FUNDING BY PROGRAM.......... 12
4.1
Federation Research Fund..................................... 12
4.2
National Personnel Awards................................... 15
4.2.1Heart and Stroke Foundation
Prestigious Awards...................................... 18
4.3
Grant-in-Aid............................................................. 19
4.4Province-specific Research Initiatives................... 23
Rôles dans la recherche........................................... 8
Éléments de l’entreprise de recherche ................. 9
la recherche en santé.............................................. 10
4FINANCEMENT DE LA RECHERCHE PAR PROGRAMME
POUR 2006-2007................................................................. 12
4.1 Fonds de recherche de la Fédération.................. 12
4.2
Bourses de fonctionnement nationales............... 15
4.2.1Prix prestigieux de la Fondation des
maladies du cœur........................................ 18
4.4.1Provincial Personnel Awards...................... 23
4.3Subvention............................................................... 19
4.4.2 Research Chairs and Professorships.......... 25
4.4
4.4.3Other Provincial Initiatives.......................... 26
4.4.1 Bourses de fonctionnement provinciales.23
4.4.2Chaires de recherche et postes de
APPENDIX A: FEDERATION RESEARCH FUND..................... 31
NEW INITIATIVES....................................................................... 34
Initiatives de recherche provinciales..................... 23
professeurs................................................... 25
4.4.3Autres initiatives provinciales..................... 26
Cardiovascular Complications of Diabetes 2007............ 34
Built Environment, Obesity and Health Development
Grants 2007 ....................................................................... 35
Reducing Health Disparities Interdisciplinary Capacity
ANNEXE A : FONDS DE RECHERCHE DE LA FÉDÉRATION.. 31
INITIATIVES NOUVELLES........................................................... 34
Complications cardiovasculaires du diabète 2007......... 34
Enhancement (ICE) Grants 2006....................................... 35
Environnement bâti, obésité et santé 2007..................... 35
Focus on Stroke 5 2006...................................................... 36
Réduire les disparités sur le plan de la santé -
CONTINUING INITIATIVES........................................................ 38
Subventions aux équipes interdisciplinaires de
Programs of Research................................................................. 38
renforcement des capacités (EIRC) 2006......................... 35
Childhood Obesity Operating Grants 2005.................... 38
Opération AVC 5 2006....................................................... 36
Genomic Medicine and Human Development 2005..... 39
INITIATIVES EN COURS.............................................................. 38
Vascular Health and Dementia Operating Grants 2005... 39
Programmes de recherche......................................................... 38
Vascular Health and Dementia Operating Grants 2004... 40
Bourses de fonctionnement en obésité chez les
Addressing Health Care & Health Policy Challenges
enfants 2005....................................................................... 38
of Genetic Medicine 2004................................................. 41
Inflammation and Thrombosis 2004................................. 41
Subventions à la santé et à la démence vasculaires 2005.... 39
Molecular and Cellular Imaging 2004.............................. 42
Subventions à la santé et à la démence vasculaires 2004.... 40
Obesity New Emerging Teams (NET) 2004..................... 43
Relever les défis des soins et des politiques de santé
Obesity New Emerging Teams (NET) 2003..................... 43
Palliative / End of Life Care 2004...................................... 44
Médecine génomique et développement humain 2005.... 39
de la médecine génétique 2004..........................................41
Inflammation et thrombose 2004.........................................41
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Fondation des maladies du cœur | Rapport de recherche 2006-2007
Regenerative Medicine 2004............................................. 45
Imagerie moléculaire et cellulaire 2004...............................42
Resuscitation Outcomes Consortium 2004..................... 45
Équipes en voie de formation sur l’obésité (EVF) 2004....43
Équipes en voie de formation sur l’obésité (EVF) 2003....43
Sex, Gender & Cardiovascular Disease Interdisciplinary
Capacity Enhancement 2004............................................. 46
Soins palliatifs et de fin de vie 2004................................. 44
ICRH/HSF New Emerging Teams (NET) 2003................. 47
Médecine régénérative 2004............................................ 45
Chronic Disease New Emerging Teams (NET) 2002....... 48
Consortium sur les résultats de la réanimation 2004..... 45
Gene-Environment Interactions Interdisciplinary Health
Amélioration de la capacité de recherche
Research Teams (IHRTs) 2002............................................ 49
interdisciplinaire sur le sexe social, le sexe
Training Programs....................................................................... 51
biologique et les maladies cardiovasculaires 2004........ 46
Focus on Stroke 4 2005...................................................... 51
Focus on Stroke 3 2004...................................................... 53
Équipes en voie de formation sur les maladies
Focus on Stroke 2 2003...................................................... 54
Focus on Stroke 1 2002...................................................... 55
Équipes en voie de formation ISCR/FMC (EVF) 2003.... 47
chroniques (EVF) 2002........................................................ 48
Équipes interdisciplinaires de recherche en santé
Andres Petrasovits Scholarship 2004................................ 55
(ÉIRS) sur les interactions entre les gènes et
Canadian Tobacco Control Research Initiative 2004...... 56
l’environnement 2002......................................................... 49
Target Obesity Personnel Awards 2004........................... 56
Programmes de formation......................................................... 51
Strategic Training Initiative in Health Research
Opération AVC 4 2005....................................................... 51
(STIHR) 2003....................................................................... 58
Strategic Training Initiative in Health Research
(STIHR) 2002....................................................................... 60
Opération AVC 3 2004....................................................... 53
Opération AVC 2 2003....................................................... 54
Opération AVC 1 2002....................................................... 55
APPENDIX B: NATIONAL PERSONNEL AWARDS................. 63
La bourse de recherche Andres Petrasovits 2004........... 55
Initiative canadienne de recherche pour la lutte
Doctoral Research Awards................................................. 64
Research Fellowships......................................................... 70
New Investigators............................................................... 74
Initiative stratégique de formation en recherche
Visiting Scientist.................................................................. 76
Nursing Research Fellowships.......................................... 76
Industry-Supported Research Personnel Awards........... 77
APPENDIX C: GRANTS-IN-AID................................................. 81
contre le tabagisme 2004.................................................. 56
Bourses Objectif Obésité 2004......................................... 56
dans le domaine de la santé (ISFRS) 2003....................... 58
Initiative stratégique de formation en recherche
dans le domaine de la santé (ISFRS) 2002....................... 60
ANNEXE B : BOURSES DE FONCTIONNEMENT
British Columbia/Yukon..................................................... 82
NATIONALES........................................................ 63
Alberta/Northwest Territories/Nunavut........................... 86
Bourses de recherche au doctorat................................... 64
Saskatchewan . ................................................................... 91
Bourses de perfectionnement en recherche................... 70
Manitoba ............................................................................ 92
Bourses de nouveaux chercheurs..................................... 74
Ontario ................................................................................ 94
Bourse de chercheur invité................................................ 76
Quebec ............................................................................. 116
Bourses de perfectionnement en sciences infirmières.. 76
New Brunswick . ............................................................... 124
Bourses de fonctionnement en recherche financées
Nova Scotia ...................................................................... 125
APPENDIX D: RESEARCH CHAIRS AND
PROFESSORSHIPS........................................... 127
par l’industrie....................................................................... 77
ANNEXE C : SUBVENTIONS..................................................... 81
Colombie-Britannique / Yukon......................................... 82
Alberta / Territoires du Nord-Ouest / Nunavut............... 86
Saskatchewan...................................................................... 91
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Manitoba ............................................................................ 92
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
APPENDIX E: OTHER PROVINCIAL INITIATIVES.................. 129
Ontario ................................................................................ 94
British Columbia/Yukon................................................... 130
Québec ............................................................................. 116
Alberta/Northwest Territories/Nunavut......................... 130
Nouveau-Brunswick . ....................................................... 124
Saskatchewan.................................................................... 130
Nouvelle-Écosse............................................................... 125
Manitoba .......................................................................... 130
Ontario............................................................................... 131
Quebec.............................................................................. 133
Nova Scotia....................................................................... 134
Prince Edward Island........................................................ 134
ANNEXE D : CHAIRES DE RECHERCHE ET POSTES
DE PROFESSEURS............................................. 127
ANNEXE E : AUTRES INITIATIVES PROVINCIALES................ 129
Colombie-Britannique / Yukon....................................... 130
APPENDIX F: RESEARCH COMMITTEE MEMBERS............. 135
Alberta / Territoires du Nord-Ouest / Nunavut ........... 130
Saskatchewan.................................................................... 130
APPENDIX G: D
EFINITION OF HEALTH RESEARCH
THEMES............................................................. 141
Manitoba .......................................................................... 130
Ontario .............................................................................. 131
Québec ............................................................................. 133
TABLES
Nouvelle-Écosse............................................................... 134
Table 1. Summary Federation-wide and Province-specific
Île-du-Prince-Édouard...................................................... 134
Research Funding (2006-2007)....................................... 3
Table 2. Detailed Federation-wide and Province-specific
ANNEXE F : MEMBRES DU COMITÉ DE LA RECHERCHE.... 135
Research Funding (2006-2007)....................................... 5
Table 3. Number of National Personnel Awards and
ANNEXE G : DÉFINITION DES THÈMES DE LA
Investment of Funds (2006-2007)................................. 16
RECHERCHE EN SANTÉ................................... 141
Table 4. HSF National Personnel Awards by Health
Research Theme (2006-2007)....................................... 16
Table 5. Number of Grants-in-Aid and Investment of
Funds (2006-2007)......................................................... 19
Table 6. HSF Provincial Personnel Awards Funded
(2006-2007)..................................................................... 23
TABLEAUX
Tableau 1. Sommaire du financement spécifique à la
recherche dans l’ensemble de la Fédération et
des provinces (2006-2007).......................................... 4
Tableau 2. Détails du financement spécifique à la recherche
Table 7. Research Chairs and Professorships (2006-2007)....... 25
dans l’ensemble de la Fédération et des
Table 8. Other Provincial Research Initiatives (2006-2007)...... 26
provinces (2006-2007)................................................. 6
Tableau 3. Nombre de bourses de fonctionnement
nationales et montants investis (2006-2007).......... 16
Tableau 4. Bourses de fonctionnement nationales de la
FMC par thème de recherche en santé
(2006-2007)................................................................. 16
Tableau 5. Nombre de subventions et fonds investis
(2006-2007)................................................................. 19
Tableau 6. Bourses de fonctionnement des FMC
provinciales (2006-2007)........................................... 24
Tableau 7. Chaires de recherche et postes de professeurs
(2006-2007)................................................................. 25
Tableau 8. Autres initiatives de recherche provinciales
(2006-2007)................................................................. 27
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Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
FIGURES
FIGURES
Figure 1. HSF Research Funding by Program (2006-2007)....... 9
Figure 1. Financement de la FMC à la recherche, par
Figure 2. HSF Research Funding Trends by Program
(2002-2007)................................................................... 10
Figure 3. HSF Research Funding by Health Research
Theme (2006-2007)...................................................... 11
Figure 4. HSF Research Funding Trends by Health
Research Theme (2004-2007)..................................... 11
Figure 5. Federation Research Fund Leveraged Funding
(2002-2007)................................................................... 13
Figure 6. Federation Research Fund Funding by Health
Research Theme (2006-2007)..................................... 14
Figure 7. Federation Research Fund Funding Trends by Health
Research Theme (2004-2007)..................................... 14
Figure 8. National Personnel Awards Funding by Health
Research Theme (2006-2007)..................................... 17
Figure 9. National Personnel Awards Funding Trends by
Health Research Theme (2002-2007)......................... 17
Figure 10. Number of National Personnel Awards
Applications Submitted and Funded by Province/
Territory (2006-2007).................................................. 18
Figure 11. Grants-in-Aid Funding by Health Research
Theme (2006-2007).................................................... 20
Figure 12. Grants-in-Aid Funding Trends by Health
Research Theme (2002-2007)................................... 20
Figure 13. Number of Grant-in-Aid Applications
Submitted by Province/Territory (2002-2007)......... 21
Figure 14. Number of Grant-in-Aid Applications Funded by
Province/Territory (2002-2007).................................. 21
programme (2006-2007)...................................................9
Figure 2. Tendances de financement de la FMC à la
recherche, par programme (2002-2007).......................10
Figure 3. Financement de la FMC à la recherche, par
thème de recherche en santé (2006-2007)...................11
Figure 4. Tendances du financement de la FMC à la
recherche, par thème de recherche en santé
(2004-2007)........................................................................11
Figure 5. F
inancement bonifié du Fonds de recherche de la
Fédération (2002-2007)...................................................13
Figure 6. F
inancement du Fonds de recherche de la
Fédération par thème de recherche en santé
(2006-2007)........................................................................14
Figure 7. Tendances du financement du Fonds de
recherche de la Fédération par thème de
recherche en santé (2004-2007).....................................14
Figure 8. Financement des bourses de fonctionnement
nationales par thème de recherche en santé
(2006-2007)........................................................................17
Figure 9. Tendances du financement des bourses de
fonctionnement nationales par thème de
recherche (2002-2007).....................................................17
Figure 10. Nombre de demandes de bourses de
fonctionnement nationales présentées et
financées par province/territoire (2006-2007)............18
Figure 11. Financement des subventions par thème de
recherche en santé (2006-2007)...................................20
Figure 12. Tendances du financement des subventions
par thème de recherche en santé (2002-2007)...... 20
Figure 13. Nombre de demandes de subventions
présentées par province/territoire (2002-2007)...... 22
Figure 14. Nombre de demandes de subventions
financées par province /territoire (2002-2007)....... 22
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Heart and Stroke Foundation | Research Report 2006-2007
MESSAGE FROM THE
CHAIR, RESEARCH POLICY
AND PLANNING ADVISORY
COMMITTEE
As the current Chair of the Research Policy and Planning Advisory
Committee (RPPAC), I am proud to present the 2006-2007 Heart
and Stroke Foundation (HSF) Research Report. It lists all of the
federation’s research investments made from July 1, 2006 to June
30, 2007.
Since 1956, HSF has funded research to reduce the burden of
cardio- and cerebrovascular disease. Our research funding
extends across the prevention-treatment-care continuum and the
four health research themes: basic biomedical, clinical, health
services/systems, and population health. In 2006-2007, HSF
invested over $50 million in research. This was made possible
by the generous donations of Canadians from coast to coast to
coast. Our investments were further extended by an additional
$11 million through the contribution of diverse organizations to
partnered research initiatives.
I would like to acknowledge the outstanding leadership of
Carolyn Brooks as Chair of RPPAC in 2006-2007. Achievements
by the expert and dedicated members of RPPAC during her
tenure include launching the first three HSF-led strategic
Requests for Applications through the Federation Research Fund
within the obesity and resuscitation priority areas, completing
an environmental scan in stroke, and completing the Personnel
Awards Program Review process.
Likewise, Dr. Grant Pierce, Scientific Review Committee Chair,
and Dr. Heather Arthur, Vice Chair, provided exemplary
leadership to over 1,000 volunteer peer reviewers. The expertise
and commitment of our scientific and lay reviewers enable HSF
to fund the highest standard of scientific excellence.
I would also like to thank and congratulate each one of our HSF
researchers for the extraordinary work they do to improve the
health and quality of life of all Canadians.
Looking to the future, the Heart and Stroke Foundation is
taking its widely acknowledged leadership role in knowledge
generation and application to new levels. The time is past to
think of the burden of heart disease and stroke in isolation.
This belief is reflected in our strategic priority areas and partnership philosophy. The HSF mission statement articulates our
commitment to knowledge transfer and exchange (KTE). For the
research enterprise, this will mean integrating KTE strategies, as
Fondation des maladies du cœur | Rapport de recherche 2006-2007
MESSAGE DU PRÉSIDENT
DU COMITÉ CONSULTATIF
SUR LES POLITIQUES ET
LA PLANIFICATION DE LA
RECHERCHE
À titre de président du Comité consultatif pour la planification et les
politiques de la recherche (CCPPR), je suis fier de présenter le Rapport
de recherche 2006-2007 de la Fondation des maladies du cœur (FMC).
Ce rapport énumère l’ensemble des investissements en recherche
effectués par la fédération entre le 1er juillet 2006 et le 30 juin 2007.
Depuis 1956, la FMC a financé la recherche destinée à réduire le
fardeau imposé par les maladies du cœur et les accidents vasculaires
cérébraux (AVC). Le financement que nous offrons à la recherche
couvre l’ensemble des activités, de la prévention aux traitements et
aux soins, ainsi que les quatre thèmes de la recherche : recherche
biomédicale fondamentale, recherche clinique, recherche sur les
services et systèmes de santé et recherche sur la santé des populations. En 2006-2007, la FMC a investi plus de 50 millions de dollars
dans la recherche. Cet investissement a été rendu possible grâce aux
généreux dons que nous avons reçus de Canadiens et de Canadiennes
de partout au pays. Nos investissements ont été complétés par une
somme additionnelle de 11 millions de dollars versée à titre de
contribution par divers organismes à des initiatives de recherche
effectuées en partenariat.
J’aimerais souligner le leadership exceptionnel de Carolyn Brooks
à titre de présidente du CCPPR en 2006-2007. Les réalisations des
spécialistes et des membres dévoués du CCPPR au cours de sa
présidence comprennent notamment le lancement des trois premiers
Appels de soumissions stratégiques dirigés par la FMC dans le cadre
du Fonds de recherche de la Fédération, portant sur les domaines
prioritaires de l’obésité et de la réanimation, l’exécution complète d’un
survol environnemental en matière d’AVC ainsi que la conclusion du
processus de révision du programme des bourses de fonctionnement.
De la même façon, Dr Grant Pierce, président du Comité d’examen
scientifique, et Dre Heather Arthur, vice-présidente du même comité,
ont guidé de façon exemplaire plus d’un millier d’examinateurs bénévoles dans le cadre du processus d’examen par les pairs. L’expertise
et l’engagement de nos examinateurs scientifiques et examinateurs
non spécialisés permet à la FMC d’atteindre les plus hautes normes
d’excellence scientifique.
J’aimerais aussi remercier et féliciter chacun de nos chercheurs de la
FMC pour le travail extraordinaire qu’ils ont accompli afin d’améliorer
la santé et la qualité de vie des Canadiens et des Canadiennes.
En se tournant vers l’avenir, la Fondation des maladies du cœur joue
son rôle de chef de file reconnu dans la production du savoir et son
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Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
appropriate, across all HSF research programs, to ensure that
research is applied to improve practice and/or policy.
application à d’autres niveaux. L’époque où l’on considérait le fardeau
des maladies du cœur et des AVC de façon isolée est désormais
révolue. Cette croyance se reflète dans nos domaines de priorité
stratégique et dans notre philosophie de partenariat. L’énoncé de
mission de la FMC exprime notre engagement envers le transfert et le
partage des connaissances. Pour l’entreprise de recherche, cela signifie
intégrer les stratégies de transfert et de partage des connaissances,
comme il convient, dans l’ensemble des programmes de recherche
de la FMC afin d’assurer la mise en application de la recherche et
l’amélioration de la pratique et des politiques.
The content of this report exemplifies the incredible efforts of
thousands of individuals toward achieving our mission, and the
remarkable possibilities that exist to make a difference in the
lives of Canadians and people across the world.
Sincerely,
Robert Côté, MD
Chair, Research Policy and Planning Advisory Committee
Le contenu du présent rapport représente les efforts immenses
déployés par des milliers de personnes en vue de réaliser notre
mission, ainsi que les remarquables possibilités qui nous sont
offertes afin de faire une différence dans la vie des Canadiens,
des Canadiennes et des personnes du monde entier.
Sincèrement,
Robert Côté, M.D.
Président, Comité consultatif sur les politiques et la planification
de la recherche
1. PURPOSE AND SCOPE
1. OBJECTIFS ET PORTÉE
The purpose of this report is twofold:
L’objectif du présent rapport comporte deux volets :
1. To illustrate the Heart and Stroke Foundation’s (HSF) overall
research investments made in 2006-2007 across all research
funding programs and initiatives.
1. Illustrer l’ensemble des investissements en recherche effectués par la
Fondation des maladies du cœur (FMC) en 2006-2007 dans le cadre
des programmes et initiatives de financement de la recherche.
2. To serve as a reference tool for volunteers and staff across the
Heart and Stroke Foundation, the research community, other
research funding agencies, and academic institutions.
This report covers the period from July 1, 2006 to June 30, 2007.
It is a snapshot of expenditures in research during that period.
The report presents financial and statistical data for new grants
and awards made in 2006-2007, as well as continued funding of
previously reported multi-year grants and awards.
2
2. Servir d’outil de référence pour les bénévoles et le personnel
dans l’ensemble de la Fondation des maladies du cœur, de la
communauté scientifique, des autres agences de financement de la
recherche et des établissements d’enseignement.
Ce rapport couvre la période entre le 1er juillet 2006 et le 30 juin 2007. Il
dresse un portrait des dépenses en recherche au cours de cette période.
Le rapport présente des données financières et statistiques concernant
les nouvelles subventions et bourses accordées en 2006-2007, ainsi
que le financement continu accordé précédemment dans le cadre de
subventions et de bourses sur plus d’une année.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
2. SUMMARY TABLES
Table 1. Summary Federation-wide and Province-specific Research Funding (2006-2007)
Foundation
Federation-wide Research Initiatives
Grant-in-Aid
#
National
Personnel
Awards
$
#
Province-specific Research Initiatives
Federation
Research Fund
$
#
$
Personnel
Awards
#
Chairs
$
#
Total
Other
$
#
$
#
$
British Columbia/
Yukon
47
4,107,282
-
-
-
-
-
-
3
340,000
1
60,000
51
4,507,282
Alberta/
Northwest Territories/
Nunavut
63
3,391,659
-
-
-
-
-
-
3
333,462
4
20,000
70
3,745,121
Saskatchewan
10
581,500
-
-
-
-
3
13,500
-
-
-
100,000
13
695,000
Manitoba
21
840,700
-
-
-
-
8
34,000
-
-
1
10,000
30
884,700
Ontario
247
20,054,167
-
-
-
- 149
4,262,475
6
630,118 14
5,212,821
416
30,159,581
Quebec
88
1,335,514
-
-
-
-
-
-
-
- 15
140,000
103
1,475,514
7
349,160
-
-
-
-
-
-
-
-
-
-
7
349,160
New Brunswick
Nova Scotia
10
476,676
-
-
-
-
-
-
-
-
1
5,000
11
481,676
Prince Edward Island
-
-
-
-
-
-
-
-
-
-
2
12,000
2
12,000
Newfoundland and
Labrador
-
-
-
-
-
-
-
-
-
-
-
-
-
-
All Foundations
-
- 167
4,575,377 129
3,675,352
-
-
-
-
-
428,571†
296
8,679,300
493
31,136,658 167
4,575,377 129
3,675,352 160
4,309,975
12
1,303,580 38
5,988,392
999
50,989,334
TOTAL
† HSF contributions to the CSN total $3 million (1999-2006)
3
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
2. TABLEAUX SOMMAIRES
Tableau 1. Sommaire du financement spécifique à la recherche dans l’ensemble de la Fédération et des provinces
(2006-2007)
Fondation
Initiatives de recherche à l’échelle de la Fédération
Subventions
#
Bourses
de fonctionnement
nationales
$
#
Initiatives de recherche provinciales
Fonds de
recherche de la
Fédération
$
#
$
Bourses
#
Chaires
$
#
Total
Autres
$
#
$
#
$
Colombie-Britannique /
Yukon
47
4 107 282
-
-
-
-
-
-
3
340 000
1
60 000
51
4 507 282
Alberta /
Territoires du Nord-Ouest /
Nunavut
63
3 391 659
-
-
-
-
-
-
3
333 462
4
20 000
70
3 745 121
Saskatchewan
10
581 500
-
-
-
-
3
13 500
-
-
-
100 000
13
695 000
Manitoba
21
840 700
-
-
-
-
8
34 000
-
-
1
10 000
30
884 700
Ontario
247
20 054 167
-
-
-
-
149
4 262 475
6
630 118
14
5 212 821
416
30 159 581
Québec
88
1 335 514
-
-
-
-
-
-
-
-
15
140 000
103
1 475 514
Nouveau-Brunswick
Nouvelle-Écosse
Île-du-Prince-Édouard
7
349 160
-
-
-
-
-
-
-
-
-
-
7
349 160
10
476 676
-
-
-
-
-
-
-
-
1
5 000
11
481 676
-
-
-
-
-
-
-
-
-
-
2
12 000
2
12 000
Terre-Neuve-et-Labrador
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Toutes les Fondations
-
-
167
4 575 377
129
3 675 352
-
-
-
-
-
428 571 †
296
8 679 300
493
31 136 658
167
4 575 377
129
3 675 352
160
4 309 975 12
1 303 580
38
5 988 392
999
50 989 334
TOTAL
† Contributions totales de la FMC au Réseau canadien contre les accidents cérébrovasculaires – 3 millions de dollars (1999-2006)
4
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Table 2. Detailed Federation-wide and Province-specific Research Funding (2006-2007)
Province/Territory
Program
British Columbia/Yukon
Grant-in-Aid
Awards (#)
Awards ($)
47
4,107,282
Chair in Stroke Research
1
110,000
Chair in Cardiovascular Research
1
160,000
Professorship in Stroke Research
1
70,000
1
60,000
63
3,391,659
4
20,000
Chair in Cardiovascular Research
1
173,462
Professorship in Stroke Research
2
160,000
10
581,500
3
13,500
-
100,000
21
840,700
Total ($)
Research Chairs†:
Other Provincial Initiatives:
Special Initiative: CardioSHARE - Cardiovascular Health and Research Environment
Alberta/
Northwest Territories/
Nunavut
Grant-in-Aid
4,507,282
Other Provincial Initiatives:
Young Investigator Travel Award
Research Chairs :
†
Saskatchewan
Grant-in-Aid
3,745,121
Personnel Awards:
Summer Student Scholarship
Other Provincial Initiatives:
Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source
Manitoba
Grant-in-Aid
695,000
Personnel Awards:
B.Sc. Medical Student
4
18,000
Red River College (RRC) Student
4
16,000
Other Provincial Initiatives:
R.E. Beamish Award
Ontario
Grant-in-Aid
1
10,000
247
20,054,167
884,700
Personnel Awards:
Distinguished Scientist
6
135,000
31
2,682,475
Clinician Scientist
8
537,000
Research Fellowship
1
47,500
Nursing Post-Doctoral Research Fellowship
3
177,000
Masters Studentship
21
378,000
Summer Student Scholarship
79
305,500
Chair in Cardiovascular Research
5
527,629
Chair in Cardiac Nursing
1
102,489
Program Grant
6
1,240,000
Health Behaviour Research Initiative (GIA)
1
209,242
Stroke Rehabilitation
4
641,039
Age 45+ with Elevated Systolic Blood Pressure
3
757,315
HSF Centre for Stroke Recovery
-
1,646,000
HSF/Richard Lewar Centre of Excellence‡
-
600,000
Publication cost
-
119,225 30,159,581
Career Investigator
Research Chairs†:
Other Provincial Initiatives:
5
Heart and Stroke Foundation | Research Report 2006-2007
Province/Territory
Program
Quebec
Grant-in-Aid
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awards (#)
Awards ($)
Total ($)
88
1,335,514
13
100,000
2
40,000
1,475,514
349,160
Other Provincial Initiatives:
Awards of Excellence
Training Bursaries
New Brunswick
Grant-in-Aid
7
349,160
Nova Scotia
Grant-in-Aid
10
476,676
1
5,000
Project Grant
1
10,000
Program Funding
1
2,000
12,000
-
-
-
Other Provincial Initiatives:
Gregory Ferrier Award
Prince Edward Island
Newfoundland and
Labrador
481,676
Other Provincial Initiatives:
Grant-in-Aid
SUBTOTAL
703
Federation Research Fund
129
3,675,352
3,675,352
National Personnel Awards
167
4,575,377
4,575,377
Canadian Stroke Network*
-
428,571
428,571
TOTAL
999
42,310,034 42,310,034
50,989,334 50,989,334
† For the most part, Research Chair awards are funded by endowments and are partnered with academic / health research institutions.
‡ HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009)
* Total $3 million (1999-2006)
Tableau 2. Détails du financement spécifique à la recherche dans l’ensemble de la Fédération et des provinces (2006-2007)
Province/Territoire
Colombie-Britannique/Yukon
Programme
Subvention
Nombre de
Montant des
bourses
bourses ($)
47
Total ($)
4 107 282
Chaires de recherche† :
Chaire de recherche sur les AVC
1
110 000
Chaire de recherche cardiovasculaire
1
160 000
Poste de professeur en recherche sur les AVC
1
70 000
1
60 000
63
3 391 659
4
20 000
Chaire de recherche cardiovasculaire
1
173 462
Poste de professeur en recherche sur les AVC
2
160 000
10
581 500
3
13 500
-
100 000
Autres initiatives provinciales :
Initiative spéciale : CardioSHARE – Environnement de santé et de
recherche cardiovasculaire
Alberta/
Territoires du Nord-Ouest/
Nunavut
Subvention
4 507 282
Autres initiatives provinciales :
Bourse de déplacement pour jeune chercheur
Chaires de recherche :
†
Saskatchewan
Subvention
3 745 121
Bourses de fonctionnement :
Bourse d’été pour étudiant
Autres initiatives provinciales :
Le faisceau d’imagerie et de traitement biomédical du Centre canadien
de rayonnement synchrotron
6
695 000
Heart and Stroke Foundation | Research Report 2006-2007
Province/Territoire
Manitoba
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Programme
Subvention
Nombre de
Montant des
bourses
bourses ($)
21
Total ($)
840 700
Bourses de fonctionnement :
Étudiant au baccalauréat en médecine
4
18 000
Étudiant du Collège Red River
4
16 000
Autres initiatives provinciales :
Bourse R.E. Beamish
Ontario
Subvention
1
10 000
247
20 054 167
884 700
Bourses de fonctionnement :
Chercheur émérite
Chercheur de carrière
6
135 000
31
2 682 475
537 000
Chercheur clinicien
8
Perfectionnement en recherche
1
47 500
Perfectionnement en recherche post-doctorale sur les soins infirmiers
3
177 000
Bourse d’études à la maîtrise
21
378 000
Bourse d’été pour étudiant
79
305 500
Chaire de recherche cardiovasculaire
5
527 629
Chaire de recherche sur les soins infirmiers cardiovasculaires
1
102 489
6
1 240 000
Chaires de recherche† :
Autres initiatives provinciales :
Subvention de programme
Québec
Initiative de recherche sur les comportements liés à la santé (subvention)
1
209 242
Réadaptation d’AVC
4
641 039
45 ans et plus avec tension artérielle systolique élevée
3
757 315
Centre de réadaptation d’AVC de la FMC
-
1 646 000
Centre d’excellence FMC/Richard Lewar ‡
-
600 000
Coûts de publication
-
119 225
88
1 335 514
13
100 000
Subvention
30 159 581
Autres initiatives provinciales :
Prix d’excellence
2
40 000
1 475 514
Nouveau-Brunswick
Subvention
Bourses de formation
7
349 160
349 160
Nouvelle-Écosse
Subvention
10
476 676
1
5 000
Subvention de projet
1
10 000
Financement de programme
1
2 000
-
-
-
703
42 310 034
42 310 034
Autres initiatives provinciales :
Bourse Gregory Ferrier
Île-du-Prince-Édouard
Terre-Neuve-et-Labrador
481 676
Autres initiatives provinciales :
Subvention
SOUS-TOTAL
12 000
Fonds de recherche de la Fédération
129
3 675 352
3 675 352
Bourses de fonctionnement nationales
167
4 575 377
4 575 377
-
428 571
428 571
999
50 989 334
50 989 334
Réseau canadien contre les accidents cérébrovasculaires *
TOTAL
† Dans la plupart des cas, les chaires de recherche sont financées par des dotations et en partenariat avec la recherche universitaire et en santé.
‡ Centre d’excellence FMC/Richard Lewar – 6 millions de dollars (1999-2009)
* Total 3 millions de dollars (1999-2006)
7
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
3. RESEARCH FUNDING
OVERVIEW
3. SURVOL DU FINANCEMENT
DE LA RECHERCHE
3.1
3.1
Research Roles
Rôles dans la recherche
Heart and Stroke Foundation of Canada
La Fondation des maladies du cœur du Canada
• Manages the peer review for all Grants-in-Aid (GIA).
• Gère le processus d’examen par les pairs pour toutes les demandes
de subventions.
• Manages peer review and award administration for all National
Personnel Awards.
• Manages peer review and award administration for all aspects
of the Federation Research Fund (FRF) strategic initiatives.
Provincial Heart and Stroke Foundations
• Administer Grants-in-Aid, including funding decisions, award
administration, monitoring and evaluation.
• Manage all aspects, including peer review, of province-specific
research initiatives. An exception is the Heart and Stroke
Foundation of Ontario (HSFO) Career Investigator program,
reviewed by a standing Heart and Stroke Foundation of Canada
(HSFC) subcommittee.
3.2
Scientific Review Process
Scientific peer review is the cornerstone of the Foundation’s
research enterprise. All research funded by HSF, at a national
or provincial level, undergoes peer review and must meet criteria
for scientific rigor.
The Scientific Review Committee (SRC) is responsible for
maintaining a gold standard peer review process for all
applications reviewed through HSFC. The SRC advises the
Research Policy and Planning Advisory Committee (RPPAC),
a HSFC Board standing committee, on matters related to
peer review.
In 2006-2007, over 125 of Canada’s top cardio- and cerebrovascular
scientists participated on the SRC, which is organized around
subcommittees, each having specific expertise.
Collectively, with the input of external reviewers, the SRC has
the ability to expertly review applications focusing on any health
research theme, from basic biomedical to population health.
For the past several years, HSFC has been innovative in adding lay reviewers to subcommittees reviewing GIA and Senior
Personnel Awards applications. The objectives of the lay reviewer
role are to enhance the accountability and integrity of the HSF
peer review process, provide an additional mechanism for
8
• Gère l’examen par les pairs et l’administration des bourses pour
toutes les bourses nationales.
• Gère l’examen par les pairs et l’administration des bourses pour
tous les aspects des initiatives stratégiques du Fonds de recherche
de la Fédération.
Les Fondations des maladies du cœur provinciales
• Administrent les subventions, y compris les décisions de
financement, l’administration, la surveillance et l’évaluation
des montants accordés.
• Administrent tous les aspects, y compris l’examen par les pairs, des
initiatives provinciales de financement de la recherche, à l’exception
du Programme de bourse de chercheur de carrière de la Fondation
des maladies du cœur de l’Ontario (FMCO), dont l’examen par les
pairs est effectué par un sous-comité d’examen permanent de la
Fondation des maladies du cœur du Canada.
3.2
Processus d’examen scientifique
Le processus d’examen scientifique par les pairs constitue la pierre
d’assise de l’entreprise de recherche de la Fondation. Toute la
recherche financée par la FMC, sur les plans national et provincial,
est soumise à l’examen par les pairs et doit respecter des critères
de rigueur scientifique.
Le Comité d’examen scientifique est responsable du maintien de
la plus haute norme de qualité dans le processus d’examen par les
pairs, pour toutes les demandes examinées par la FMCC. Le Comité
d’examen scientifique conseille le Comité consultatif sur les politiques
et la planification de la recherche (CCPPR), un comité permanent
du conseil d’administration, sur les sujets couverts par l’examen par
les pairs.
En 2006-2007, plus de 125 des meilleurs chercheurs du domaine
cardiovasculaire et vasculaire cérébral au Canada ont pris part au
Comité d’examen scientifique, organisé en sous-comités ayant
chacun une expertise spécifique.
Collectivement, avec l’apport des examinateurs externes, le Comité
d’examen scientifique possède la capacité d’examiner de façon spécialisée toute demande portant sur chacun des thèmes de la recherche
en santé, de la recherche biomédicale fondamentale à la recherche
sur la santé des populations.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
evaluating relevance of projects to the HSF mission, and
increase awareness of the importance of knowledge transfer
and exchange.
Au cours des dernières années, la FMCC a innové en ajoutant des
examinateurs non spécialisés à ses sous-comités d’examen des
demandes de subventions et de bourses de chercheurs de carrière.
Les objectifs du rôle d’examinateur non spécialisé consistent à améliorer la responsabilité et l’intégrité du processus d’examen par les
pairs de la FMC, à offrir un mécanisme supplémentaire d’évaluation de
la pertinence du projet à la mission de la FMC et à mieux sensibiliser à
l’importance du partage et de l’application des connaissances.
At the provincial level, committee structure varies by province.
Research, budgetary allocation, and peer review committees all
have roles in funding and review of provincial initiatives.
Members of RPPAC, the SRC leadership, and chairs of provincial
committees for the year 2006-2007 can be found in Appendix F.
3.3
Research Enterprise Components
The HSF research enterprise contains four significant parts
presented in Figure 1. The 10 provincial Foundations invest about
$50 million annually in the Grant-in-Aid program (research project
operating grants); the National Personnel Awards program
(salary awards at doctoral, post doctoral fellowship, and new
investigator levels); the Federation Research Fund initiatives
(strategic research initiatives primarily in partnership with other
funding agencies); and provincial research initiatives (personnel
awards, program grants, research chair and other programs).
Overall funding expenditures for grants and awards have
increased from $40 million to over $50 million over the past
five years (Figure 2).
Figure 1. HSF Research Funding by Program (2006-2007)
Grant-in-Aid
$31,136,658
Provincial
Research Initiatives
$11,601,947
Federation
Research Fund
$3,675,352
National
Personnel Awards
$4,575,377
Au niveau provincial, la structure des comités varie selon la province.
Les comités de recherche, d’allocation budgétaire et d’examen par
les pairs ont tous un rôle à jouer dans le financement et l’examen des
initiatives provinciales.
On retrouve les listes des membres du CCPPR, de la direction des
comités d’examen scientifique et des présidents des comités
provinciaux pour l’année 2006-2007 à l’Annexe F.
3.3
Éléments de l’entreprise de recherche
L’entreprise de recherche de la FMC comporte quatre éléments
principaux, qui sont présentés à la Figure 1. Les 10 Fondations
provinciales investissent environ cinquante millions de dollars
annuellement dans le programme des subventions (subventions de
fonctionnement aux projets de recherche); le programme des bourses
Numbers represent
$ Millions
nationales de fonctionnement (bourses de traitement
aux niveaux
doctoral, postdoctoral et de nouveau chercheur); les initiatives du
Federation
Research
Fonds de recherche de la Fédération (initiatives
stratégiques
de Fund
recherche principalement en partenariat
avec
d’autres
agences
de
1.6
2002-2003
financement) et initiatives de recherche
provinciales
(subventions
de
2.3
2003-2004
fonctionnement, subventions de
programmes,
chaires
de
recherche
3.1
2004-2005
et autres). Les dépenses totales en subventions et en bourses ont
4.0
2005-2006
augmenté de 40 millions de dollars à 50 millions de dollars au cours
3.7
2006-2007
de cinq dernières années (Figure 2).
Personnel
Figure 1. Financement de la FMC à laNational
recherche,
par Awards
2002-2003
4.9
programme (2006-2007)
2003-2004
Subventions
31 136 658 $
2004-2005
2005-2006
2006-2007
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
fig 1 eng
4.9
5.2
Initiatives
de
4.8
recherche provinciales
4.6
11 601 947 $
Fonds de recherche
Grant-in-Aid
de la Fédération
3 675 352 $
28.0
29.0
Bourses de
fonctionnement
nationales
4 575 377 $
29.8
30.0
31.1
Provincial Research Initiatives†
fig 1 fre
2002-2003
5.9
2003-2004
5.8
2004-2005
5.9
2005-2006
6.3
2006-2007
11.6
9
Total
2002-2003
2003-2004
entions
6 658 $
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Figure 2. HSF Research Funding Trends by Program
(2002-2007)
Figure 2. Tendances de financement de la FMC à la
recherche, par programme (2002-2007)
Numbers represent $ Millions
Les valeurs indiquées sont en millions de dollars.
Federation Research Fund
Fonds de recherche de la Fédération
1.6
2002-2003
1,6
2002-2003
2003-2004
2.3
2003-2004
2,3
2004-2005
3.1
2004-2005
3,1
2005-2006
2006-2007
4.0
Initiatives de
3.7
recherche provinciales
11 601 947 $
National Personnel Awards
2002-2003
4.9
Fonds de recherche
de la Fédération
4.9
3 675 352 $
5.2
2003-2004
2004-2005
2005-2006
2006-2007
2006-2007
3,7
2003-2004
Basic
Bourses de fonctionnement
nationales
Biomedical
4,9
78%
4,9
2004-2005
5,2
2005-2006
4,8
2006-2007
4,6
2002-2003
29.0
28,0
2003-2004
29,0
2004-2005
29.8
2005-2006
2004-2005
30.0
29,8
2005-2006
30,0
2006-2007
e
31.1
2006-2007
31,1
fig 3 eng
Provincial Research Initiatives†
Initiatives de recherche provinciales †
2002-2003
5.9
2003-2004
2002-2003
5.8
5,9
2004-2005
2003-2004
5.9
5,8
2005-2006
2004-2005
6.3
5,9
2005-2006
6,3
2006-2007
11.6
2006-2007
Total
2002-2003
2003-2004
2004-2005
2005-2006
2002-2003
42.0
2003-2004
44.0
2004-2005
45.1
2006-2007
2005-2006
51.0
† Includes Research Chair values for year 2006-2007 only.
3.4
Investments across Health Research Themes
fig 2 eng
Research supported by HSF spans the four health research
themes: basic biomedical, clinical, health services/systems, and
population health (defined in Appendix G).
Figures 3 and 4 show the relative HSF investments across health
research themes. Overall, HSF research has traditionally been
10
11,6
Total
40.4
2006-2007
Hea
Syst
P
H
Subvention
28.0
2003-2004
4,0
2002-2003
Bourses
4.8 de
fonctionnement
4.6
nationales
4 575 377 $
Grant-in-Aid
2002-2003
2005-2006
Clinical
14%
40,4
42,0
44,0
45,1
51,0
† Comprend la valeur de la Chaire de recherche pour l’année 2006-2007 seulement.
3.4 Investissements dans les quatre thèmes de la recherche
en santé
fig 2 fre
La recherche appuyée par la FMC englobe les quatre thèmes de la
recherche en santé : biomédicale fondamentale, clinique, systèmes et
services de santé et santé des populations (tels que définis à l’Annexe G).
Les Figures 3 et 4 illustrent les investissements relatifs de la FMC dans les
quatre thèmes de la recherche en santé. Dans l’ensemble, la recherche
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
concentrated heavily in the basic biomedical sciences (Figure 4).
Further
inmillions
the report,
funding by health research theme in each of
leurs indiquées
sont en
de dollars.
the federation-wide programs is presented. Currently, we do not
ds de recherche
la Fédération
havede
data
on provincial initiatives by theme.
6
Figure 3. HSF Research Funding by Health Research
Theme (2006-2007)
,3
3,1
4,0
Clinical
14%
3,7
financée par la FMC a traditionnellement été fortement concentrée
sur les sciences biomédicales fondamentales (Figure 4). Plus loin dans
represent
Millions
ce rapport, on présente leNumbers
financement
par $thème
de la recherche en
santé pour chacun des programmes offerts à l’échelle de la Fédération.
Basic
Présentement, nous n’avons
en Biomedical
main aucune donnée par thème pour les
initiatives provinciales.
29.2
2004-2005
2005-2006
Figure 3. Financement
de la FMC à la recherche, par thème
2006-2007
de recherche
(2006-2007)
Clinical
Health Services/
Systems 4%
ses de fonctionnement nationales
4,9
Basic
Biomedical
78%
4,9
5,2
Population
Health 4%
4,6
Figure 4. HSF Research Funding Trends by Health Research
28,0
Theme (2004-2007)
29,0
29,8
Numbers
represent $ Millions
29.3
fig 3 eng
30.5
2006-2007
8
11,6
2005-2006
6.0
2006-2007
5.7
2004-2005
Biomédicale
2005-2006
fondamentale
78 % 2006-2007
1.9
1.6
1.4
2005-2006
1.9
2006-2007
1.6
Clinique
14 %
42,0
Santé de la
population
4%
44,0
45,1
51,0
1.4
Biomédicale fondamentale
1.6
2004-2005 2002-2003
6.3
2005-2006
29,2
fig 3 fre
29,3
fig 4 eng
2.3
30,5
2003-2004
2004-2005 2004-2005
6,1
2005-2006
6,0
2006-2007
9.2
5,7
2005-2006
3.1
11.0
4.0
13.3
Services et systèmes de santé
3.7
1,4
2004-2005 2006-2007
2005-2006
1,9
2006-2007
1,6
Population Health
11.9
HSFC
de la Chaire de
recherche pour 1.0
l’année 2006-2007 seulement.
2004-2005
Partner
Santé de la population
2005-2006
1.4
2004-2005
1,0
2006-2007
1.6
2005-2006
1,4
2006-2007
1,6
fig 3 fre fig 4 eng
Santé de la
population
4%
Clinique
Services et
systèmes de
santé 4 %
Health Services/Systems
40,4
1.4
Health Services/Systems
Population Health
2006-2007
Clinical
6.1
5.7
Les valeurs indiquées sont en millions de dollars.
Numbers
1.6 represent $ Millions
29.2
2004-2005
2006-2007
Services et
systèmes de
santé 4 %
2006-2007
2004-2005
3
6.0
2005-2006
tives de recherche
provinciales †
2005-2006
9
2005-2006
Clinique
14 %
Figure 4. Tendances du financement de la FMC à la
recherche, 2004-2005
par thème de1.0recherche en santé (2004-2007)
30,0
Basic
31,1Biomedical
9
6.1
Biomédicale
fondamentale
78 % 2004-2005
4,8
ention
2004-2005
29.3
fig 5 eng
fig 4 fre
11
30.5
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
4. 2
006-2007 RESEARCH
FUNDING BY PROGRAM
4. F
INANCEMENT DE
LA RECHERCHE PAR
PROGRAMME POUR
2006-2007
This section provides summary information for each of the four
main components of the HSF research enterprise:
Federation-wide research programs:
1.
Federation Research Fund
2.
National Personnel Awards
3.
Grant-in-Aid
4.
Province-specific research initiatives:
i. Provincial Personnel Awards
ii. Provincial Research Chairs
iii. Other Provincial Research Initiatives
4.1
Federation Research Fund
The Federation Research Fund (FRF) supports research in areas
of strategic priority to HSF, typically through a Request for
Applications process, and in partnership with other agencies
and organizations.
New initiatives appearing in this year’s report include:
1) Cardiovascular Complications of Diabetes. This is an initiative led
by the Canadian Institutes of Health Research (CIHR) Institute
of Circulatory and Respiratory Health aimed at improving the
prevention, treatment, and management of diabetes and
gaining a better understanding of the interaction between
diabetes and cardiovascular disease (CVD) risk factors.
2) B
uilt Environment, Obesity and Health. The goal of this
HSF-led initiative is to examine how the urban design of our
communities, schools, parks and transportation systems impact
health. Funding for development grants for these initiatives
appear in this report. Full project funding details will appear in
the 2007-2008 Research Report and are presently available at
www.hsf.ca/research.
3) Reducing Health Disparities. This initiative supports
multi-disciplinary research teams and aims to increase
understanding of the health status of vulnerable populations.
4) Focus on Stroke V. This highly successful training initiative to
support personnel awards in the stroke area was launched for a
sixth time. The 19 new awards funded in 2006-2007 are listed in
this report.
The majority of the projects listed in Appendix A represent the
continuation of previously reported research investments. A total
of 29 initiatives (representing 129 individual grants and awards)
are detailed in Appendix A.
12
La section qui suit offre un sommaire de l’information concernant
chacun des quatre principaux volets de l’entreprise de recherche de
la FMC :
Programmes offerts dans l’ensemble de la Fédération :
1.
Fonds de recherche de la Fédération
2.
Bourses de fonctionnement nationales
3.
Subventions
4.
Initiatives de recherche provinciales :
i. Bourses de fonctionnement provinciales
ii. Chaires de recherche provinciales
iii. Autres initiatives de recherche provinciales
4.1
Fonds de recherche de la Fédération
Le Fonds de recherche de la Fédération appuie les recherches dans
les domaines de priorité stratégique pour la FMC, habituellement par
l’entremise d’un processus d’appel de propositions et en partenariat
avec d’autres agences et organismes.
Parmi les nouvelles initiatives qui apparaissent dans le rapport de cette
année, on retrouve notamment :
1) Complications cardiovasculaires associées au diabète. Cette
initiative dirigée par l’Institut de la santé circulatoire et respiratoire
des Instituts de recherche en santé du Canada (IRSC) vise à améliorer la prévention, le traitement et la prise en charge du diabète,
dans le but de mieux comprendre l’interaction entre le diabète et
les facteurs de risque reliés aux maladies cardiovasculaires.
2) Environnement bâti, obésité et santé. L’objectif de cette initiative
placée sous la gouverne de la FMC consiste à examiner comment
l’aménagement urbain de nos collectivités, les écoles, les parcs et
les systèmes de transport affectent la santé. Le financement des
subventions de développement accordées à ces initiatives apparaît
dans le présent rapport. Les détails complets du financement des
projets seront publiés dans le Rapport de recherche 2007-2008 et
sont présentement disponibles sur le site www.hsf.ca/research.
3) Réduction des disparités en matière de santé. Cette initiative
appuie des équipes de recherche multidisciplinaires et vise à mieux
comprendre l’état de santé des populations vulnérables.
4) Opération AVC V. Cette initiative de formation couronnée de
succès a versé des bourses de recherche sur les AVC pour une
sixième reprise. Les 19 nouvelles bourses financées en 2006-2007
sont indiquées dans le présent rapport.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
The total value of HSF’s investment in these projects for 20062007 is $3.7 million. In addition to HSF’s investment, partner funds
have further extended the FRF research investments. As outlined
in Figure 5, HSF funding is leveraged by a ratio of more than
three to one. The Foundation has partnered with numerous
organizations since the FRF began, including all of the CIHR
institutes, other health charities (e.g., The Kidney Foundation
of Canada, Canadian Diabetes Association) and industry
(e.g., AstraZeneca Canada, Pfizer Canada) to maximize research
dollars in areas of common interest.
La majorité des projets qui apparaissent à l’Annexe A représente la
continuité des investissements de recherche déjà annoncés dans
les rapports précédents. En tout, 29 initiatives, représentant 129 
Figure 5. Federation Research Fund Leveraged Funding
(2002-2007)
Numbers represent $ Millions
2002-2003
2003-2004
1.6
6.3
9.2dollars.
Les valeurs indiquées sont en millions de
2004-2005
2005-2006
2006-2007 2005-2006
Clinique
2006-2007
2004-2005
6,1
2005-2006
6,0
2006-2007
5,7
11.0
29,2
1,4
13.3
30,5
3.7
11.9
HSFC
One of the objectives of the FRF is to support interdisciplinary
1,9
2005-2006
research in the areas of health services/systems and population
1,6
2006-2007
health. Figures 6 and 7 show a fairly balanced distribution of
funds across health research themes. It is important to note,
Santé dethat
la population
however,
the Federation Research Fund represents only
of overall HSF research investment.
2004-2005 10% 1,0
fig 5 eng
2005-2006
1,4
2006-2007
1,6
fig 4 fre
Basic Les valeurs indiquées sont en millions de dollars.
Clinical 27%
Biomedical 34%
1,6
2002-2003
6,3
29,3
4.0
Partner
Services et systèmes de santé
2004-2005
La valeur totale de l’investissement de la FMC dans ces projets en
2006-2007 est de 3,7 millions de dollars. En plus de l’investissement
de la FMC, les fonds avancés par les partenaires ont permis de
multiplier l’investissement du Fonds de recherche de la Fédération.
Tel que décrit à la Figure 5, le financement de la FMC est bonifié
à plus du triple de sa valeur. La Fondation a fait équipe avec de
nombreux organismes depuis la création du Fonds de recherche de
la Fédération, dont la totalité des instituts de recherche des IRSC,
d’autres organismes bénévoles en santé (par exemple, la Fondation du
rein du Canada, l’Association canadienne du diabète) et l’industrie (par
exemple, AstraZeneca Canada, Pfizer Canada) afin de maximiser le
financement de la recherche dans des domaines d’intérêt commun.
Figure 5. Financement bonifié du Fonds de recherche de
la Fédération (2002-2007)
2.3
Biomédicale fondamentale
3.1
2004-2005
subventions et bourses distinctes, sont décrites en détail à l’Annexe A.
2003-2004
2004-2005
2005-2006
2006-2007
2,3
Health Services/
Systems 19%
9,2
Population
Health
3,1 21%
11,0
4,0
13,3
3,7
11,9
FMCC
Partenaire(s)
fig 6 eng
Un des objectifs du Fonds de recherche de la Fédération consiste à
appuyer la recherche interdisciplinaire dans les domaines des services
et systèmes de santé et de la santé des populations. Les Figures 6
et 7 démontrent une distribution relativement équilibrée des fonds
entre les divers thèmes de la recherche en santé. Il est important de
souligner cependant que le Fonds de recherche de la Fédération ne
représente qu’environ 10 % de l’investissement total de la FMC dans
la recherche.
fig 5 fre
13
valeurs
indiquées sont| Research
en millions
de dollars.
Heart and Les
Stroke
Foundation
Report
2006-2007
2002-2003
Fondation des maladies du cœur | Rapport de recherche 2006-2007
1,6
6,3
Figure 6. Federation Research Fund Funding by Health
Research Theme
2,3 (2006-2007)
2003-2004
Numbers represent $ Millions
Figure 6. Financement du Fonds de recherche de la
Fédération par thème de recherche
en santé (2006-2007)
Basic Biomedical
9,2
3,1
2004-2005
Basic
Biomedical 34%
4,0
2005-2006
2006-2007
11,0
Clinical 27%
Biomédicale
fondamentale 34 %
13,3
11,9
Health Services/
Systems 19%
Partenaire(s)
Figure 7. Federation Research Fund Funding Trends by
Health Research Theme (2004-2007)
Numbers represent $ Millions
Population Health
1.0
1.2
1.2
fig 5 fre
fig 6 eng
Clinical
ig 7 eng
fig 6 fre
14
Health Services/Systems
Services et
0.7 de
systèmes
santé 19 %1.0
0.7
Clinical
10 %
Health
Services/
Biomédicale fondamentale
Systems 1%
1,0
Population
1,2
Health 3%
1,2
Les valeurs indiquées sont en millions de dollars.
2004-2005
2005-2006
2006-2007
Santé de la
2004-2005
population
2005-2006
21 %
2006-2007
Clinique 27 %
0.9
1.0
1.0
Figure 7. Tendances du
financement du Fonds
de
2004-2005
0.6
recherche de la Fédération
par thème de recherche
en
2005-2006
0.8
2006-2007
0.8
santé (2004-2007)
Basic Biomedical
2004-2005
2005-2006
2006-2007
Clinical
2004-2005
Santé de la
population2005-2006
21 %
2006-2007
FMCC
1.2
1.2
2004-2005
2005-2006
2006-2007
3,7
Population
Health 21%
2004-2005
2005-2006
2006-2007
Biomédicale
fondamentale 34 %
1.0
2004-2005
2005-2006
2006-2007
0.9
1.0
1.0
Clinique 27 %
Health Services/Systems
0.7
1.0
0.7
Population Health
0.6
0.8
0.8
Services et
systèmes de
santé 19 %
2004-2005
2005-2006
2006-2007
fig 6 fre
fig 7 eng
Clinique
2004-2005
2005-2006
2006-2007
2004-2005
2005-2006
2006-2007
0,9
1,0
Basic
1,0
Biomedical
87%
Services et systèmes de santé
0,7
1,0
0,7
Santé de la population
2004-2005
2005-2006
2006-2007
fig 8 eng
fig 7 fre
0,6
0,8
0,8
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
4.2
4.2
National Personnel Awards
National Personnel Awards build Canada’s cardio- and
cerebrovascular research capacity by providing salary support
to investigators at early scientific career stages. The 2006-2007
programs included New Investigator, Research Fellowship,
Doctoral Research Award, Nursing Research Fellowship, and
Visiting Scientist.
National Personnel Awards Programs in 2006-2007
New Investigator — A salary award to support new
investigators who wish to establish their own independent research laboratory ($50,000 per year for five years,
plus obligatory benefits).
Research Fellowship — A training award for applicants
who have completed a professional degree, MD or PhD
(up to $50,000 per year for two to three years).
Doctoral Research Award — A training award for
graduate students, enrolled in a PhD program, who are
undertaking full-time research training ($21,000 per year
for up to three years).
Nursing Research Fellowship — A training award for
nursing researchers enrolled in an MSc/MA, PhD, or
research fellowship program ($25,000 per year for up to
three years).
Visiting Scientist — A salary/travel award that enables
established investigators who visit another institution to
develop and share research expertise.
In 2006-2007, 167 new and continuing awards were funded.
This included 13 awards supported in part by industry. The total
investment in National Personnel Awards in 2006-2007 was over
$4.5 million (Table 3). A list of award recipients can be found in
Appendix B.
Bourses de fonctionnement nationales
Les bourses de fonctionnement nationales développent la capacité de
recherche cardiovasculaire et vasculaire cérébrale au Canada en aidant
à défrayer le salaire des chercheurs aux premiers stades de leur carrière
scientifique. Les programmes 2006-2007 comprennent notamment les
bourses de nouveau chercheur, de perfectionnement en recherche,
de recherche doctorale, de recherche sur les soins infirmiers et de
chercheur invité.
Programmes de bourses de fonctionnement nationales en
2006-2007
Nouveau chercheur — Bourse de traitement destinée à
appuyer les jeunes chercheurs qui désirent établir leur propre
laboratoire de recherche indépendant (50 000 dollars par
année pendant cinq ans, plus avantages obligatoires).
Perfectionnement en recherche — Bourse de formation
destinée aux candidats ayant obtenu un diplôme
professionnel M.D. ou Ph.D. (jusqu’à 50 000 dollars par
année pendant deux ou trois ans).
Recherche doctorale — Bourse de formation destinée
aux étudiants de deuxième et troisième cycle inscrits à un
programme de doctorat et qui entreprennent une formation
en recherche à temps complet (21 000 dollars par année
pendant un maximum de trois ans).
Bourse de recherche en soins infirmiers — Bourse de
formation destinée aux chercheurs en soins infirmiers
inscrits à un programme de M.Sc., M.A., Ph.D. ou de
perfectionnement en recherche (25 000 dollars par année
pendant jusqu’à trois ans).
Chercheur invité — Bourse de traitement et de
déplacement qui permet à des chercheurs établis de
visiter un autre établissement afin d’y développer et d’y
partager leur expertise en recherche.
En 2006-2007, 167 bourses, nouvelles et en cours, ont été financées.
On y retrouve 13 bourses appuyées par l’industrie. L’investissement
total dans les bourses de fonctionnement nationales en 2006-2007
a dépassé les 4,5 millions de dollars (Tableau 3). La liste des
récipiendaires se trouve à l’Annexe B.
15
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Table 3. Number of National Personnel Awards and
Investment of Funds (2006-2007)
Tableau 3. Nombre de bourses de fonctionnement
nationales et montants investis (2006-2007)
Program
Recipients (#)
Funds Invested ($)
Programme
Récipi-
Montants
investis
New Investigator
28
1,394,167
endaires
Research Fellowship
61
1,753,333
(#)
Doctoral Research Award
71
1,269,677
6
150,000
Nursing Research Fellowship
Visiting Scientist
TOTAL
1
8,200
167
4,575,377
Table 4 highlights the distribution of National Personnel Awards
by health research theme. In 2006-2007, the majority of awards
were in the basic biomedical area (86%). This is consistent with
previous years (Figures 8 and 9).
($)
Nouveau chercheur
28
1 394 167
Bourse de perfectionnement en recherche
61
1 753 333
Bourse de recherche au doctorat
71
1 269 677
Perfectionnement en recherche en soins infirmiers
6
150 000
Chercheur invité
1
8 200
167
4 575 377
TOTAL
Le Tableau 4 indique la distribution des bourses de fonctionnement
nationales par thème de recherche en santé. En 2006-2007, la majorité
de ces bourses est allée au domaine biomédical (86 %). L’accent mis
sur la recherche biomédicale est comparable aux années précédentes
(Figures 8 et 9).
Table 4. HSF National Personnel Awards by Health Research Theme (2006-2007)
Type of Award
Basic Biomedical
Clinical
(#)
($)
(#)
Total
(#)
($)
23.6
1,168,667
2.9
144,000
-
-
1.6
81,500
28.0
1,394,167
Research Fellowship
53.8
1,586,833
6.0
129,333
0.5
8,833
0.7
28,333
61.0
1,753,333
Doctoral Research Award
66.5
1,194,077
3.9
63,350
-
-
0.6
12,250
71.0
1,269,677
-
-
4.0
100,000
2.0
50,000
-
-
6.0
150,000
1.0
8,200
-
-
-
-
-
-
1.0
8,200
Visiting Scientist
($)
Population Health
New Investigator
Nursing Research Fellowship
(#)
Health Services/Systems
($)
(#)
($)
Obligatory Benefits
-
56,000
-
7,000
-
-
-
-
-
63,000
Travel Allowance (Average)
-
77,418
-
8,422
-
1,694
-
1,280
-
88,813
144.9
4,091,196
16.7
452,105
2.5
60,527
2.9
123,363
167.0
4,727,191
TOTAL
Tableau 4. Bourses de fonctionnement nationales de la FMC par thème de recherche en santé (2006-2007)
Type de bourse
Biomédicale
Clinique
Services et sys-
fondamentale
(#)
Nouveau chercheur
tèmes de santé
($)
23,6
(#)
1 168 667
($)
(#)
($)
2,9
144 000
-
-
Santé de la
Total
population
(#)
($)
(#)
1,6
81 500
28,0
($)
1 394 167
Perfectionnement en recherche
53,8
1 586 833
6,0
129 333
0,5
8 833
0,7
28 333
61,0
1 753 333
Bourse de recherche au doctorat
66,5
1 194 077
3,9
63 350
-
-
0,6
12 250
71,0
1 269 677
-
-
4,0
100 000
2,0
50 000
-
-
6,0
150 000
1,0
8 200
-
-
-
-
-
-
1,0
8 200
Perfectionnement en recherche en soins infirmiers
Chercheur invité
Prestations obligatoires
-
56 000
-
7 000
-
-
-
-
-
63 000
Frais de déplacement (moyenne)
-
77 418
-
8 422
-
1 694
-
1 280
-
88 813
144,9
4 091 196
16,7
452 105
2,5
60 527
2,9
123 363
167,0
4 727 191
TOTAL
16
Les valeurs indiquées sont en millions de dollars.
HeartBiomédicale
and Strokefondamentale
Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
1,0
2004-2005
2005-2006
Figure
2006-2007
Numbers represent $ Millions
1,2
Personnel
1,2
8. National
Awards Funding by Health
Research Theme (2006-2007)
Figure 8. Financement des bourses de fonctionnement
Basic Biomedical
nationales par thème de recherche
en santé (2006-2007)
2002-2003
Clinique
0,9
1,0
1,0
2004-2005
2005-2006
2006-2007
2004-2005
2005-2006
2006-2007
Clinical
10 %
Health
Services/
Systems 1%
Services et systèmes de santé
0,7
1,0
0,7
Santé de la
Clinical
population
0.7
3%
0.6
0.7
0.6
0.4
Biomédicale
fondamentale
Services/Systems
87Health
%
2002-2003
0
2003-2004
0.1
Figure 9. Tendances du financement des bourses
de fonc2004-2005
0.1
tionnement nationales par thème
de
recherche
(2002-2007)
2005-2006
0.1
2006-2007
0.1
Population
Health 3%
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Santé de la population
2004-2005
2005-2006
2006-2007
0,6
0,8
0,8
Basic
Biomedical
87%
Figure 9. National Personnel Awards Funding Trends by
Health Research Theme (2002-2007)
Les valeurs indiquées sont en millions de dollars.
Numbers represent $ Millions
Basic Biomedical
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
fig 7 fre
8 fre
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Clinique
10 %
Clinical Services et
systèmes de
0.7
santé 1 %
0.6
Santé de la
0.7
population
0.6
3%
0.4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Health Services/Systems
0
Biomédicale
0.1
fondamentale
0.1
87 %
0.1
0.1
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
4.1
4.2
4.0
4.2
4.0
Population Health
Biomédicale fondamentale
4,1 0.2
Numbers represent $2002-2003
Millions
2003-2004 4,2 0.3
2004-20054,0 0.2
Applications Submitted
2005-2006 4,2 0.2
Applications Funded
2006-2007 4,0 0.1
fig 8 fre
28
Clinique
B.C./Yukon
13
0,7
2002-2003
0,6
2003-2004
Alt./N.W.T./Nunavut
0,7 25
2004-2005
0,6 7
2005-2006
fig 8 eng
2006-2007
0,4
Sask.
C
Alb. / T.N.-O
fig 9 eng
5
1
Services et systèmes de santé
2002-2003
0
2003-2004 Man.
0,1 6
2004-2005
0,12
2005-2006
0,1
128
2006-2007 Ont.
0,1
33
Santé de la population
82
Que.
0,2
2002-2003
14
0,3
2003-2004
Population Health
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
4.
4
4.0
4
4.0
2003-2004
Clinique
2004-2005
10 %
2005-2006 Services et
systèmes de
2006-2007
santé 1 %
0.2
0.3
0.2
0.2
0.1
0,2
2004-2005
0
2005-2006 N.B.0,2
0,10
2006-2007
N.S. 2
There is a wide variation by province in applications submitted
and funded. Very few National Personnel Awards applications are
funded in the Atlantic provinces, Manitoba, and Saskatchewan
(Figure 10). The overall success rate for the National Personnel
Awards competitions in 2006-2007 was approximately 25%.
fig 9 eng
On retrouve de grandes
variations dans le nombre de demandes
0
présentées et financées entre les provinces. Très peu de demandes
0
P.E.I.
de bourses de
fonctionnement
nationales sont financées dans les
0
provinces de l’Atlantique,
au Manitoba et en Saskatchewan.
(Figure 10). Le taux de succès global lors des concours des bourses
Canadiens étudian
N.L. 1
de fonctionnement nationales en 2006-2007 était d’environ 25 %.
fig 9 fre
0
Canadians studying abroad
23
8
17
fig 10 eng
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Figure 10. Number of National Personnel Awards
Applications Submitted and Funded by Province/Territory
Numbers represent $ Millions
(2006-2007)
Les valeurs indiquées sont en millions de dollars.
Figure 10. Nombre de demandes de bourses de
fonctionnement nationales présentées et financées
Les valeurs indiquées sont en millions de dollars.
par province/territoire (2006-2007)
Biomédicale
fondamentale
Applications
Submitted
2002-2003
Applications Funded
2003-2004
2004-2005
28
B.C./Yukon
2005-2006
13
2006-2007
Numbers represent $ Millions
Applications
Submitted
Nombre de demandes
présentées
Nombre
de demandes financées
2002-2003
260
2003-2004
275
238
282004-2005
C.-B. / Yukon
13 2005-2006
2006-2007
4,1
4,2
4,0
4,2
4,0
25
Clinique
7
0,7
2002-2003
0,6
2003-2004
Sask. 5
0,7
2004-2005
1
0,6
2005-2006
0,4
2006-2007
Man. 6
2
Services et systèmes de santé
2002-2003
0
128
Ont.
2003-2004
0,133
2004-2005
0,1
2005-2006
0,1
82
Que.
2006-2007
140,1
N.B.
2002-2003
2003-2004
2004-2005
N.S.
2005-2006
2006-2007
1
Man.
6
2
Applications Funded
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
86
52
74
53
78
Applications Rated Very Good
or Above
128
Ont.
2002-2003
151
33
2003-2004
180
2004-2005
164
82
Qc
228
14 2005-2006
2006-2007
196
Santé de la population
0
0 0,2
0,3
2 0,2
0 0,2
0,1
N.-B. 0
0
N.-É. 2
0
Î.-P.-É. 0
0
N.L. 1
0
T.-N.-L. 1
0
fig 9 fre
fig 11 eng
23
8
Heart and Stroke Foundation Prestigious Awards
Each year, two outstanding New Investigators are recognized for
their scientific excellence through the following prestigious HSF
awards. Recipients are awarded a $15,000 research allowance
(in addition to the $50,000 New Investigator award stipend).
fig 10 eng
McDonald Scholarship
The McDonald Scholarship Award is named in honour of
Ewing McDonald, the Heart and Stroke Foundation of Canada’s
Executive Director from 1968 to 1987. This award is given annually
to the highest-rated applicant in the New Investigator program.
Dr. Angela Devlin, of the University of British Columbia, was the
Heart and Stroke Foundation’s 2006-2007 McDonald Scholar.
Dr. Devlin’s research is focussed on the effects on a baby’s gene
function of a mother’s nutrition during pregnancy and the
implications for future heart disease and stroke.
18
5
Sask.
P.E.I. 0
0
Canadians studying abroad
4.2.1
25
7
Alb. / T.N.-O. / Nunavut
Alt./N.W.T./Nunavut
Canadiens étudiant à l’étranger
4.2.1
23
8
Prix prestigieux de la Fondation des maladies
du cœur
Chaque année, deux nouveaux chercheurs exceptionnels voient
récompenser leur excellence scientifique par les prix prestigieux
suivants de la FMC. Les récipiendaires reçoivent 15 000 dollars
d’allocation de recherche (en plus des 50 000 dollars de la Bourse
de nouveau chercheur).  
fig 10 fre
Bourse McDonald
La bourse McDonald a été instaurée en l’honneur de Ewing McDonald,
directeur général de la Fondation des maladies du cœur du Canada
de 1968 à 1987. Cette bourse est remise annuellement au candidat
ayant obtenu la plus haute note au concours de nouveau chercheur.
Dre Angela Devlin, de l’Université de la Colombie-Britannique, est
récipiendaire de la Bourse McDonald pour 2006-2007. Les recherches
de Dre Devlin portent sur les effets de la nutrition de la mère au cours
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Henry J.M. Barnett Scholarship
The Henry J.M. Barnett Scholarship Award was established to
honour Dr. Henry J.M. Barnett’s exceptional contributions to
stroke research, education, and patient care in Canada. This
award is presented annually to a highly rated New Investigator
applicant working in stroke research. Dr. Michael Colicos, of the
University of Calgary, was the Heart and Stroke Foundation’s
2006-2007 Barnett Scholar. The focus of Dr. Colicos’s research is
synaptic remodelling and the potential applications for recovery
from stroke.
de la grossesse sur le fonctionnement des gènes du bébé, ainsi que
ses implications sur sa santé cardiovasculaire future.
4.3
Bourse Henry J.M. Barnett
La Bourse Henry J.M. Barnett a été instaurée en hommage à la
contribution exceptionnelle de Dr Henry J.M. Barnett en recherche et
en éducation sur les AVC ainsi que sur les soins aux patients d’AVC au
Canada. Ce prix est présenté annuellement à un nouveau chercheur
ayant obtenu une note élevée et travaillant en recherche sur les AVC.
Dr Michael Colicos, de l’Université de Calgary, est récipiendaire de la
Bourse Barnett de la Fondation des maladies du cœur pour 2006-2007.
Les travaux de Dr Barnett portent sur le remodelage synaptique et ses
applications en récupération d’AVC.
Grant-in-Aid
Grants-in-Aid (peer-reviewed nationally, but funded and
administered provincially) are the largest category of research
expenditure for the Heart and Stroke Foundation. The Grant-inAid program supports the direct operating costs of conducting
research, including laboratory supplies, technicians, and some
equipment. Grant amounts vary, but typically range from $14,000
to a maximum of $200,000 per year.
In 2006-2007, 493 Grants-in-Aid (new and continuing) were
funded, representing an investment of over $31 million (Table 5).
A list of grant recipients can be found in Appendix C.
Table 5. Number of Grants-in-Aid and Investment of
Funds (2006-2007)
Province/Territory
Subvention
Les subventions, qui sont évaluées par les pairs sur le plan national,
mais financées et administrées par les provinces, représentent la
catégorie la plus importante de dépenses en recherche de la
Fondation des maladies du cœur. Le programme de subventions
couvre les coûts directs de fonctionnement de la recherche, comme
les fournitures de laboratoire, les techniciens et certains équipements.
Le montant des subventions varie, mais se situe habituellement entre
14 000 dollars et un maximum de 200 000 dollars par année.
En 2006-2007, 493 subventions (nouvelles et en cours) ont été financées,
ce qui représente un investissement de plus de 31 millions de dollars
(Tableau 5). La liste des récipiendaires se trouve à l’Annexe C.
Recipients
Funds Invested
(#)
($)
Tableau 5. Nombre de subventions et fonds investis
(2006-2007)
British Columbia/Yukon
47
4,107,282
Alberta/Northwest Territories/
Nunavut
63
3,391,659
Saskatchewan
10
581,500
Manitoba
21
840,700
Ontario
247
20,054,167
Quebec
88
1,335,514
7
349,160
New Brunswick
4.3
Province/Territoire
4 107 282
Alberta /
Territoires du Nord-Ouest /
Nunavut
63
3 391 659
Saskatchewan
10
581 500
Manitoba
21
840 700
247
20 054 167
88
1 335 514
7
349 160
10
476 676
Île-du-Prince-Édouard
-
-
Terre-Neuve-et-Labrador
-
-
493
31 136 658
10
476,676
-
-
Québec
Newfoundland and Labrador
-
-
Nouveau-Brunswick
493
31,136,658
Grants-in-Aid are heavily concentrated ($25 million or 80% of
overall expenditure) in the basic biomedical sciences (Figures 11
and 12).
($)
47
Prince-Edward-Island
TOTAL
Montants investis
(#)
Colombie-Britannique / Yukon
Ontario
Nova Scotia
Récipiendaires
Nouvelle-Écosse
TOTAL
Les subventions sont fortement concentrées (soit 25 millions de
dollars ou 80 % des sommes investies) dans les sciences biomédicales
fondamentales (Figures 11 et 12).
19
2003-2004
275
2004-2005
238
2005-2006
307
2006-2007
300 Report 2006-2007
Heart and Stroke Foundation | Research
2002-2003
86
Figure 52
11. Grants-in-Aid
2003-2004
2004-2005
74
Theme (2006-2007)
2005-2006
53
2006-2007
78
Basic Biomedical
Funding by Health Research
Demandes évaluées comme
très bonnes ou supérieures
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
151
2004-2005
2005-2006 Clinique
Services et
2006-2007 14 %
systèmes de
santé 3 %
Clinical
4.8 Santé de la
2002-2003
population
5.2
2003-2004
2%
4.5
2004-2005
4.5
2005-2006
4.3
2006-2007
Biomédicale
fondamentale
81 %
Health Services/Systems
Clinical
14 %
Health
Services/
Systems 3%
228
196
Basic
Biomedical
81%
Figure 12. Grants-in-Aid Funding Trends by Health
Research Theme (2002-2007)
Numbers represent $ Millions
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
fig 12 eng
Biomédicale fondamentale
22.7
23.2
24.6
24.0
25.3
Clinical
4.8
2002-2003
5.2
2003-2004
4.5
2004-2005
4.5
2005-2006 Clinique
14 % 4.3Services et
2006-2007
systèmes de
santé 3 %
Health Services/Systems
Santé de la
2002-2003
0
population
2003-2004
0
2%
2004-2005
0.6
2005-2006
0.9
Biomédicale
2006-2007
0.9
fondamentale
81 %
Population Health
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
0.6
0.6
0.3
0.6
0.7
Again, as in the National Personnel Awards competitions, the
number of applications submitted and funded in the Grant-in-Aid
program varies widely across provinces (Figures 13 and 14).
The average Grant-in-Aid amount invested in 2006-2007 was
approximately $63,158 with Ontario offering the largest maximum
grant amount ($165,072). The overall success rate for the
Grant-in-Aid competition in 2006-2007 was 52%.
fig 13 eng
2002-2003
0
2003-2004
Figure 12. Tendances de financement0des
2004-2005
0.6
thème de recherche en santé
(2002-2007)
2005-2006
0.9
2006-2007
0.9
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
fig 12 fre
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Clinique
4,8
5,2
4,5
4,5
4,3
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
0
0
0,6
0,9
0,9
Santé de la population
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
0,6
0,6
0,3
0,6
0,7
Numbers represent $ Million
Population Health
B.C./Yukon
22,7
2002-2003
0.6
23,2
2003-2004
0.6
2004-2005
0.3 24,6
2005-2006
0.624,0
2006-2007
0.7 25,3
32
34
44
40
40
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alta./N.W.T./Nunavut
49
51
52
48
45
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
14
14
12
8
7
fig 13 eng
Services et systèmes de santé
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
14
6
23
10
14
Ont.
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Une fois de plus, comme c’est le cas des concours
de bourses de
fonctionnement nationales, le nombre de demandes soumises
Que. et
financées dans le cadre du programme des subventions
varie
62
2002-2003
considérablement entre les provinces (Figures 2003-2004
13 et 14). Le montant 62
63
moyen versé en subvention en 2006-2007 était2004-2005
d’environ 63 158 dollars
64
2005-2006
et l’Ontario offrait le montant maximum de subvention le plus élevé,
fig 13 fre
22.7
23.2
24
24.
2
subventions par
Les valeurs indiquées sont en millions de dollars.
Basic Biomedical
20
Figure 11. Financement des
subventions par thème de
2002-2003
2003-2004
recherche en santé (2006-2007)
Population
Health 2%
180
164
g 11 fre
e
Fondation des maladies du cœur | Rapport de
recherche
2006-2007
Numbers
represent
$ Millions
Nombre de demandes financées
2006-2007
51
soit 165 072 dollars. Le taux de succès dans le cadre du concours
N.B.
2002-2003 5
2003-2004 3
2004-2005 2
2005-2006 0
2006-2007 4
de subventions en 2006-2007 était de 52 %.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Figure 13. Number of Grant-in-Aid Applications Submitted
by Province/Territory (2002-2007)
Figure 14. Number of Grant-in-Aid Applications Funded by
Province/Territory (2002-2007)
esent $ Millions
Numbers represent $ Millions
Numbers represent $ Millions
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
B.C./Yukon
32
34
44
40
40
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
B.C./Yukon
16
14
15
16
19
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
B.C./Yukon
16
14
15
16
19
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alta./N.W.T./Nunavut
49
51
52
48
45
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alta./N.W.T./Nunavut
29
24
35
23
28
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alta./N.W.T./Nunavut
29
24
35
23
28
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
14
14
12
8
7
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
4
5
6
4
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
4
5
6
4
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
12
4
18
4
8
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
12
4
18
4
8
Nunavut
2
2
3
4
Numbers represent $ Millions
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
14
6
23
10
14
Ont.
2002-2003 181
2003-2004 174
214
2004-2005
207
2005-2006
201
2006-2007
Ont.
181
174
214
207
201
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Que.
Que.
62
62
63
64
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
51
N.L.
1
0
2
3
1
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.L.
1
0
2
3
1
105
84
102
104
95
Que.
34
32
29
30
32
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.B.
N.S.
9
11
15
9
10
P.E.I.
2002-2003
0
2002-2003
2003-2004
1
2003-2004
2004-2005
1
2004-2005
2005-2006
3
2005-2006
2006-2007
0
2006-2007
34
32
29
30
32
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.B.
2002-2003 5
2003-2004 3
2004-2005 2
2005-2006 0
2006-2007 4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Ont.
105
2002-2003
84
2003-2004
1022004-2005
104
2005-2006
95 2006-2007
N.B.
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
2
2
1
0
2
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.S.
4
6
9
2
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
P.E.I.
0
0
0
0
0
P.E.I. N.L.
2002-2003
1
0
2002-2003
2003-2004
0
0
2003-2004
2004-2005
1
0
2004-2005
2005-2006
0
0
2005-2006
2006-2007
1
0
2006-2007
2002-2003 2
2003-2004 2
2004-2005 1
2005-2006 0
2006-2007 2
N.S.
4
6
9
2
4
20022003200420052006-
21
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Figure 13. Nombre de demandes de subventions
présentées
par province/territoire (2002-2007)
Les valeurs indiquées sont en millions de dollars.
Figure 14. Nombre de demandes de subventions financées
par province/territoire (2002-2007)
Les valeurs indiquées sont en millions de
quées sont en millions de dollars.
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
C.-B. / Yukon
32
34
44
40
40
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
C.-B. / Yukon
16
14
15
16
19
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
C.-B. / Yukon
16
14
15
16
19
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alb. / T.N.-O. / Nunavut
49
51
52
48
45
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alb. / T.N.-O. / Nunavut
29
24
35
23
28
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Alb. / T.N.-O. / Nunavut
29
24
35
23
28
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
14
14
12
8
7
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
4
5
6
4
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Sask.
4
5
6
4
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
12
4
18
4
8
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
12
4
18
4
8
/ Nunavut
2
2
3
4
Les valeurs indiquées sont en millions de dollars.
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Man.
14
6
23
10
14
Ont.
2002-2003 181
2003-2004 174
2004-2005
214
2005-2006
207
2006-2007
201
214
207
201
51
22
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
T.-N.-L.
1
0
2
3
1
102
104
95
34
32
29
30
32
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.-B.
N.-B.
2002-2003 2
2003-2004 2
2004-2005 1
2005-2006 0
2006-2007 2
N.-É.
9
11
15
9
10
Î.-P.-É.T.-N.-L.
2002-2003
0
2002-2003
1
2003-2004
1
2003-2004
0
2004-2005
1
2004-2005
2
2005-2006
3
2005-2006
3
2006-2007
0
2006-2007
1
34
32
29
30
32
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
105
84
Qc
Qc
62
62
63
64
N.-B.
2002-2003 5
2003-2004 3
2004-2005 2
2005-2006 0
2006-2007 4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
2002-2003
105
2003-2004
84
1022004-2005
2005-2006
104
95 2006-2007
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Qc
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Ont.
Ont.
181
174
2002-2003 2
2003-2004 2
2004-2005 1
2005-2006 0
2006-2007 2
N.-É.
4
6
9
2
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
N.-É.
4
6
9
2
4
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
2002-2003
2003-2004
2004-2005
2005-2006
2006-2007
Î.-P.-É.
0
0
0
0
0
Î.-P.-É.T.-N.-L.
2002-2003
0
1
2002-2003
2003-2004
0
0
2003-2004
2004-2005
0
1
2004-2005
2005-2006
0
0
2005-2006
2006-2007
0
1
2006-2007
20022003200420052006-
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
4.4
4.4
Province-specific Research Initiatives
Initiatives de recherche provinciales
In addition to the Grant-in-Aid program, many of the provincial
Foundations administer provincial Personnel Awards, Research
Chairs, and other research initiatives.
En plus du programme de subventions, plusieurs fondations
provinciales administrent leurs propres bourses de fonctionnement,
chaires de recherche et autres initiatives de recherche.
4.4.1
4.4.1
Provincial Personnel Awards
In 2006-2007, the provincial Foundations funded a total of 168
Personnel Awards, building capacity by supporting cardio- and
cerebrovascular researchers throughout their careers, from
high school students working in research settings through to
established senior scientists (Table 6).
Bourses de fonctionnement provinciales
En 2006-2007, les Fondations provinciales ont financé en tout 168
bourses de fonctionnement destinées à améliorer la capacité de
recherche en appuyant des chercheurs du domaine cardiovasculaire et
vasculaire cérébral à toutes les étapes de leur carrière, des élèves du
secondaire travaillant en milieu de recherche aux chercheurs de
carrière solidement établis (Tableau 6).
Table 6. HSF Provincial Personnel Awards Funded (2006-2007)
Province/Territory
Program
British Columbia/Yukon
-
-
-
-
Alberta/Northwest Territories/Nunavut -
-
-
-
Saskatchewan
Summer Student Scholarship
3
13,500
13,500
Manitoba
B.Sc. Medical Student
4
18,000
Red River College (RRC) Student
4
16,000
Ontario
Distinguished Scientist
Awards (#)
Awards ($)
Total ($)
6
135,000
31
2,682,475
Clinician Scientist
8
537,000
Research Fellowship
1
47,500
Career Investigator
Nursing Post-Doctoral Research Fellowship
34,000
3
177,000
Masters Studentship
21
378,000
Summer Student Scholarship
79
305,500
4,262,475
Quebec
-
-
-
-
New Brunswick
-
-
-
-
Nova Scotia
-
-
-
-
Prince Edward Island
-
-
-
-
Newfoundland and Labrador
-
-
-
-
160
4,309,975
4,309,975
TOTAL
23
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Tableau 6. Bourses de fonctionnement des FMC provinciales (2006-2007)
Province/Territoire
Programme
Colombie-Britannique / Yukon
-
Alberta / Territoires du Nord-Ouest /
Nunavut
-
-
-
Saskatchewan
Bourse d’été pour étudiant
3
13 500
13 500
Manitoba
Étudiant au baccalauréat en médecine
4
18 000
Étudiant du Collège Red River
4
16 000
Ontario
Chercheur émérite
6
135 000
31
2 682 475
Chercheur de carrière
Nombre de bourses
Montant des bourses ($)
-
-
Chercheur clinicien
8
537 000
Perfectionnement en recherche
1
47 500
Perfectionnement en recherche postdoctorale sur les soins infirmiers
3
177 000
Bourse d’études à la maîtrise
21
378 000
Bourse d’été pour étudiant
79
Total ($)
-
34 000
305 500
4 262 475
Québec
-
-
-
-
Nouveau-Brunswick
-
-
-
-
Nouvelle-Écosse
-
-
-
-
Île-du-Prince-Édouard
-
-
-
-
Terre-Neuve-et-Labrador
-
TOTAL
24
-
-
-
160
4 309 975
4 309 975
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
4.4.2
4.4.2
Research Chairs and Professorships
Research Chair funding provides salary and infrastructure
support to enable a leading researcher to develop a particular
research focus at a Canadian university. In 2006-2007 a total of
12 Chairs and Professorships were supported by HSF in the areas
of cardiology, stroke, and cardiac nursing. This represents an
investment of over $1 million (see Table 7). The recipients of these
Chairs and Professorships can be found in Appendix D.
Chaires de recherche et postes de professeurs
Le financement des chaires de recherche offre un soutien salarial et
d’infrastructure permettant à un chercheur émérite de développer des
intérêts de recherche particuliers au sein d’une université canadienne.
En tout, 12 chaires et postes de professeurs sont financés par la FMC
dans les domains de la cardiologie, des AVC et des soins infirmiers
cardiovasculaires. Cet investissement représente plus d’un million de
dollars (voir le Tableau 7). Les titulaires de ces chaires et postes de
professeurs sont mentionnés à l’Annexe D.
Table 7. Research Chairs and Professorships (2006-2007)†
Province/Territory
Program
British Columbia/Yukon
Chair in Stroke Research
Awards (#)
1
Awards ($)
110,000
Total ($)
Chair in Cardiovascular Research
1
160,000
Professorship in Stroke Research
1
70,000
Chair in Cardiovascular Research
1
173,462
Professorship in Stroke Research
2
160,000
333,462
Saskatchewan
-
-
-
-
Manitoba
-
-
-
-
Ontario
Chair in Cardiovascular Research
5
527,629
Chair in Cardiac Nursing Research
1
102,489
630,118
Quebec
-
-
-
-
New Brunswick
-
-
-
-
Nova Scotia
-
-
-
-
Prince Edward Island
-
-
-
-
Newfoundland and Labrador
-
-
-
-
12
1,303,580
1,303,580
Alberta/Northwest Territories/Nunavut
TOTAL
340,000
† For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions.
Tableau 7. Chaires de recherche et postes de professeurs (2006-2007)†
Province/Territoire
Programme
Nombre de
Montant des
Colombie-Britannique / Yukon
Chaire de recherche sur les AVC
1
110 000
Chaire de recherche cardiovasculaire
1
160 000
Poste de professeur en recherche sur les AVC
1
70 000
Chaire de recherche cardiovasculaire
1
173 462
Poste de professeur en recherche sur les AVC
2
160 000
333 462
bourses
Alberta / Territoires du Nord-Ouest / Nunavut
Total ($)
bourses ($)
340 000
Saskatchewan
-
-
-
-
Manitoba
-
-
-
-
Ontario
Chaire de recherche cardiovasculaire
5
527 629
Chaire de recherche sur les soins infirmiers
cardiovasculaires
1
102 489
630 118
Québec
-
-
-
-
Nouveau-Brunswick
-
-
-
-
Nouvelle-Écosse
-
-
-
-
Île-du-Prince-Édouard
-
-
-
-
Terre-Neuve-et-Labrador
-
-
-
-
12
1 303 580
1 303 580
TOTAL
† Dans la plupart des cas, les chaires de recherche sont financées par des dotations et en partenariat avec la recherche universitaire et en santé.
25
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
4.4.3
4.4.3
Other Provincial Initiatives
In 2006-2007, the provincial Foundations funded a wide variety of
other research initiatives. Table 8 provides details of these initiatives and recipients can be found in Appendix E.
Autres initiatives provinciales
En 2006-2007, les Fondations provinciales ont financé une vaste
gamme d’autres initiatives de recherche. Le Tableau 8 offre des détails
sur ces initiatives et la liste des récipiendaires se retrouve à l’Annexe E.
Table 8. Other Provincial Research Initiatives (2006-2007)
Province/Territory
Program
Awards (#)
Awards ($)
British Columbia/Yukon
Special Initiative: CardioSHARE - Cardiovascular Health and Research
Environment
Total ($)
1
60,000
60,000
Alberta/Northwest Territories/Nunavut
Young Investigator Travel Award
4
20,000
20,000
Saskatchewan
Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian
Light Source
-
100,000
100,000
Manitoba
R.E. Beamish Award
1
10,000
10,000
1,240,000
Ontario
Quebec
New Brunswick
Program Grant
6
Health Behaviour Research Initiative (GIA)
1
209,242
Stroke Rehabilitation
4
641,039
Age 45+ with Elevated Systolic Blood Pressure
3
757,315
HSF Centre for Stroke Recovery
-
1,646,000
HSF/Richard Lewar Centre of Excellence†
-
600,000
Publication cost
-
119,225
Awards of Excellence
5,212,821
13
100,000
Training Bursaries
2
40,000
140,000
-
-
-
5,000
Nova Scotia
Gregory Ferrier Award
1
5,000
Prince Edward Island
Project Grant
1
10,000
Program Funding
1
2,000
-
-
-
-
-
428,571
428,571
38
5,988,392
5,988,392
Newfoundland and Labrador
Canadian Stroke Network‡
TOTAL
† HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009)
‡ Total $3 million (1999-2006)
26
12,000
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Tableau 8. Autres initiatives de recherche provinciales (2006-2007)
Province/Territoire
Colombie-Britannique / Yukon
Programme
Initiative spéciale: CardioSHARE – Environnement de santé et
de recherche cardiovasculaire
Nombre de
Montant des
bourses
bourses ($)
Total ($)
1
60 000
60 000
Alberta / Territoires du Nord-Ouest /
Nunavut
Bourse de déplacement pour jeune chercheur
4
20 000
20 000
Saskatchewan
Faisceau d’imagerie et de traitement biomédical du Centre de
rayonnement canadien synchrotron
-
100 000
100 000
Manitoba
Bourse R.E. Beamish
1
10 000
10 000
Ontario
Subvention de programme
6
1 240 000
Initiative de recherche sur les comportements liés à la santé
(subvention)
1
209 242
Réadaptation d’AVC
4
641 039
45 ans et plus avec tension artérielle systolique élevée
3
757 315
Centre de réadaptation d’AVC de la FMC
-
1 646 000
Centre d’excellence FMC/Richard Lewar†
-
600 000
Coûts de publication, etc.
Québec
Prix d’excellence
Bourses de formation
-
119 225
13
100 000
2
40 000
5 212 821
140 000
Nouveau-Brunswick
-
-
-
-
Nouvelle-Écosse
Bourse Gregory Ferrier
1
5 000
5 000
Île-du-Prince-Édouard
Subvention de projet
1
10 000
Financement de programme
1
2 000
-
-
-
-
-
428 571
428 571
38
5 988 392
5 988 392
Terre-Neuve-et-Labrador
Réseau canadien contre les accidents cérébrovasculaires‡
TOTAL
12 000
† Centre d’excellence FMC/Richard Lewar – 6 millions de dollars (1999-2009)
‡ Contributions totales – 3 millions de dollars (1999-2006)
Description of Other Provincial Research Initiatives
Description des autres initiatives de recherche provinciales
Heart and Stroke Foundation of British Columbia & Yukon
(HSFBCY)
Special Initiative: CardioSHARE - Cardiovascular Health and
Research Environment — HSFCBY is investing $360,000 over two
years (March 1, 2007 to Feb. 28, 2009) to develop a data search,
classification, and management system for ischemic heart disease.
Fondation des maladies du cœur de la Colombie-Britannique
et du Yukon (FMCCBY)
Heart and Stroke Foundation of Alberta, NWT & Nunavut
(HSFA)
Young Investigator Travel Awards — HSFA offers an award to
new investigators who choose a Canadian Institutes of Health
Research (CIHR) grant instead of an HSFA Grant-in-Aid. The
Young Investigator Travel Awards promote collaborative future
relationships between leading research labs and the Foundation.
Initiative spéciale : CardioSHARE - Environnement de santé et de
recherche cardiovasculaire — la FMCCBY investit 360 000 dollars sur
deux ans (1er mars 2007 au 28 février 2009) afin de développer
un système de recherche, de classification et de gestion des
données reliées aux maladies cardiaques ischémiques.
Fondation des maladies du cœur de l’Alberta, des T.-N.-O. et
du Nunavut (FMCA)
Bourses de déplacement pour jeune chercheur — La FMCA offre
également une bourse à l’intention de jeunes chercheurs qui choisissent une subvention des Instituts de recherche en santé du Canada
(IRSC) au lieu d’une subvention de la FMCA pour le même projet. La
Bourse de déplacement pour jeune chercheur favorise la création de
liens futurs entre les laboratoires de recherche et la Fondation.
27
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Heart and Stroke Foundation of Saskatchewan (HSFS)
Biomedical Imaging and Therapy (BMIT) Beamline at the
Canadian Light Source — Located at the University of
Saskatchewan, the Canadian Light Source is Canada’s national
centre for synchrotron research. The BMIT beamline is a powerful
new tool for the imaging, study and treatment of disease. This
facility is funded through a broad-based partnership of
supporters, including HSFS.
Fondation des maladies du cœur de la Saskatchewan (FMCS)
Heart and Stroke Foundation of Manitoba (HSFM)
R.E. Beamish Award — HSFM offers an award of excellence in
cardiac research. This award is given to the highest rated HSFM
GIA recipient in honour of cardiac researcher Dr. Robert Beamish,
one of the primary founders of HSFM more than 50 years ago.
Award-winning Dr. Beamish served in numerous medical offices
and positions throughout his career. He was, and continues to
be, a well-respected researcher and well-known for his impact on
cardiology in Manitoba.
Faisceau d’imagerie et thérapie biomédicales (BMIT) du Centre
canadien de rayonnement synchrotron — Situé à l’Université de la
Saskatchewan, le Centre canadien de rayonnement synchrotron est le
centre national canadien de recherche en rayonnement synchrotron.
Le faisceau BMIT est un nouvel outil puissant d’imagerie, d’étude
et de traitement des maladies. Ces installations sont financées par
l’entremise d’un vaste partenariat de supporteurs, dont la FMCS.
Fondation des maladies du cœur du Manitoba (FMCM)
Prix R.E. Beamish — La FMCM offre un prix d’excellence en recherche
cardiovasculaire. Ce prix est remis au récipiendaire de subvention de
la FMCM ayant obtenu la meilleure note, en hommage au chercheur
en cardiologie Dr Robert Beamish, un des principaux fondateurs de la
FMCM, voilà plus de 50 ans. Récipiendaire de plusieurs distinctions,
Dr Beamish a siégé à de nombreux postes et au sein de nombreuses
instances médicales au cours de sa carrière. Il a été et continue d’être
un chercheur respecté et renommé pour son impact en cardiologie
dans la province du Manitoba.
Heart and Stroke Foundation of Ontario (HSFO)
Program Grants — These grants provide support for teams
of three or more investigators engaging in collaborative multidisciplinary research in the fields of cardio- and cerebrovascular
disease in Ontario institutions.
Fondation des maladies du cœur de l’Ontario (FMCO)
Health Behaviour Research Initiative (GIA) — A special strategic
Request for Applications was launched to promote research to
find more effective ways of encouraging and supporting populations and individuals in initiation and maintenance of behaviours
that improve cardio-cerebrovascular health.
Initiative de recherche sur les comportements de santé (subvention)
— Un appel spécial de soumissions a été lancé afin de promouvoir
la recherche visant à découvrir de nouvelles façons d’encourager et
d’appuyer plus efficacement les populations et les individus à
adopter et à conserver des comportements qui améliorent la santé
Stroke Rehabilitation — This Request for Applications is geared
to multi-institute, multi-disciplinary, collaborative applications to
support research into stroke rehabilitation.
Réadaptation d’AVC — Cet appel de soumissions est destiné aux
demandes collaboratives multicentriques et multidisciplinaires, afin
Age 45+ with Elevated Systolic Blood Pressure — To better
understand this area, HSFO launched a research competition
focused on managing elevated systolic blood pressure in
individuals aged 45 years and older.
Tension artérielle systolique élevée chez les 45 ans et plus — Afin de
mieux comprendre ce domaine, la FMCO a lancé un concours de
recherche portant sur la prise en charge de la tension artérielle
Subventions de programme — Ces subventions offrent un soutien aux
équipes de trois chercheurs ou plus qui prennent part à des recherches
collaboratives et multidisciplinaires dans les domaines des maladies du
cœur et des AVC au sein des établissements ontariens.
cardiovasculaire et vasculaire cérébrale.
d’appuyer la recherche sur la réadaptation d’AVC.
systolique élevée chez les personnes âgées de 45 ans et plus.
Publication Costs — HSFO reimburses grant recipients for costs
related to publications resulting from work completed during the
granting period.
Coûts de publication — La FMCO rembourse aux récipiendaires de
subventions les coûts reliés aux publications résultant des travaux
Heart and Stroke Foundation of Quebec (HSFQ)
Awards of Excellence — A number of Awards of Excellence are
awarded each year by HSFQ in partnership with individual and
corporate donors. These awards enhance the Grants-in-Aid and
provide additional financial support to Quebec researchers. The
awards range from $5,000 to $20,000.
Fondation des maladies du cœur du Québec (FMCQ)
28
effectués durant la période de subvention.
Prix d’excellence — Un certain nombre de Prix d’excellence sont
décernés chaque année par la FMCQ en partenariat avec des
donateurs individuels et corporatifs. Ces prix servent à bonifier les
subventions et apportent un soutien financier additionnel aux
chercheurs québécois. Ces prix vont de 5 000 dollars à 20 000 dollars.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Training Bursaries — The Training Bursaries are awarded by
HSFQ, in partnership with the Fonds de la recherche en santé
du Québec and the Réseau en santé cardiovasculaire, to
PhD students.
Bourses de formation — Les bourses de formation sont décernées
par la FMCQ, en partenariat avec le Fonds de recherche en santé
du Québec et le Réseau de santé cardiovasculaire, à des étudiants
Heart and Stroke Foundation of Nova Scotia (HSFNS)
Gregory Ferrier Award — HSFNS offers an award of excellence
in research. This award is given to the highest rated HSFNS GIA
recipient in honour of Dr. Ferrier, an internationally respected,
award-winning scientist known for his groundbreaking and
innovative research program related to heart failure mechanisms.
The award also honours the spirit of Dr. Ferrier’s mentorship to
a new generation of researchers; he went above and beyond to
ensure they were able to conduct their research in Nova Scotia.
Fondation des maladies du cœur de la Nouvelle-Écosse
(FMCNÉ)
Heart and Stroke Foundation of Prince Edward Island (HSFPEI)
Project Grant — HSFPEI provides funding for a research project
related to heart disease and stroke.
Program Funding — HSFPEI sponsors a speaker at the Prince
Edward Island Health Research Forum.
au doctorat.
Bourse Gregory Ferrier — La FMCNÉ offre une bourse d’excellence
en recherche. Cette bourse est décernée au récipiendaire de
subvention ayant obtenu la meilleure note, en hommage au Dr Ferrier,
un chercheur émérite respecté dans le monde entier pour ses travaux
de pionnier et ses recherches innovatrices sur les mécanismes liés à
l’insuffisance cardiaque. Le prix rend hommage à l’esprit de mentorat
de Dr Ferrier auprès d’une nouvelle génération de chercheurs;
Dr Ferrier s’est surpassé afin de leur permettre de mener des
recherches en Nouvelle-Écosse.
Fondation des maladies du cœur de l’Île-du-Prince-Édouard
(FMCÎPÉ)
Subvention de projet — La FMCÎPÉ finance un projet de recherche
relié aux maladies du cœur et aux AVC.
Financement de programme — La FMCÎPÉ commandite un
conférencier dans le cadre du Forum de la recherche en santé de
l’Île-du-Prince-Édouard.
29
Heart and Stroke Foundation | Research Report 2006-2007
30
Fondation des maladies du cœur | Rapport de recherche 2006-2007
APPENDIX
Annexe
A
FEDERATION RESEARCH FUND
FONDS DE RECHERCHE DE LA FÉDÉRATION
Dr. Christian Vaillancourt (University of Ottawa) and Dr. Ian Stiell (Ottawa Health Research Institute) were recipients in 2006-2007 of an award funded
through the Federation Research Fund’s Resuscitation Outcomes Consortium 2004 initiative, titled Proposal to create a Canadian collaborative RCC.
Dr Christian Vaillancourt (Université d’Ottawa) et Dr Ian Stiell (Institut de recherche en santé d’Ottawa) étaient lauréats en 2006-2007 d’une bourse
financée par l’initiative Consortium sur les retombées de la réanimation 2004 du Fonds de recherche de la Fédération, intitulée Proposition pour la
création d’un CCR collaboratif canadien.
Heart and Stroke Foundation | Research Report 2006-2007
Acronym
Acronyme
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Full name of organization
Nom complet de l’organisme
ACB.......................................................Alberta Cancer Board
AHFMR.................................................Alberta Heritage Foundation for Medical Research
AstraZeneca.........................................AstraZeneca Canada Inc.
ASC/SAC..............................................Alzheimer Society of Canada / Société Alzheimer du Canada
BCCA....................................................British Columbia Cancer Agency
CBS / SCS.............................................Canadian Blood Services / Société canadienne du sang
CCMB...................................................Cancer Care Manitoba
CCOHTA / OCCETS............................Canadian Coordinating Office for Health Technology Assessment / Office canadien de coordination
de l’évaluation des technologies de la santé
CCS / SCC............................................Canadian Cardiovascular Society / Société canadienne de cardiologie
CDA / ACD...........................................Canadian Diabetes Association / Association canadienne du diabète
CIHR / IRSC..........................................Canadian Institutes of Health Research / Instituts de recherche en santé du Canada
CIHR - Ethics / IRSC Éthique..............CIHR Ethics Office / Bureau de l’éthique des IRSC
CIHR - GHRI / IRSC-IRSM....................CIHR Global Health Research Initiative / Initiative des IRSC sur la recherche en santé mondiale
CIHR - HIV/AIDS / IRSC VIH/sida.......CIHR HIV/AIDS Research Initiative / Initiative de recherche des IRSC sur le VIH/sida
CIHR-KT / IRSC-AC..............................CIHR - Knowledge Translation Branch / Direction de l’application des connaissances des IRSC
CIHR/Rx&D / programme Rx&D
des IRCS...............................................CIHR/Rx&D Collaborative Research Program / IRSC et Rx&D - Programme de bourses de recherche
CLA / APC............................................Canadian Lung Association / Association pulmonaire du Canada
CSN / RCACV.......................................Canadian Stroke Network / Réseau canadien contre les accidents cérébrovasculaires
CTCRI / ICRCT.....................................Canadian Tobacco Control Research Initiative / Initiative canadienne de recherche pour la lutte
contre le tabagisme
FPT Task Group on Genomics and
Health / Groupe de travail FPT sur
la génétique et la santé......................“Federal, Provincial, Territorial Task Group on Genomics and Health / Groupe de travail
fédéral-provincial-territorial sur la génomique et la santé“
HC / SC.................................................Health Canada / Santé Canada
HSF / FMC............................................Heart and Stroke Foundation / Fondation des maladies du cœur
IA / IV....................................................Institute of Aging / Institut du vieillissement
IAPH / ISA.............................................Institute of Aboriginal Peoples’ Health / Institut de la santé des Autochtones
ICR / IC.................................................Institute of Cancer Research / Institut du cancer
ICRH / ISCR..........................................Institute of Circulatory Respiratory Health / Institut de la santé circulatoire et respiratoire
IG / IG...................................................Institute of Genetics / Institut de génétique
IGH / ISFH............................................Institute of Gender and Health / Institut de la santé des femmes et des hommes
32
Acronym
Acronyme
Full name of organization
Nom complet de l’organisme
IHDCYH / IDSEA..................................Institute of Human Development, Child and Youth Health / Institut du développement et de la
santé des enfants et des adolescents
IHSPR / ISPS.........................................Institute of Health Services and Policy Research / Institut des services et des politiques de la santé
III / IMII..................................................Institute of Infection and Immunity / Institut des maladies infectieuses et immunitaires
IMHA / IALA.........................................Institute of Musculoskeletal Health and Arthritis / Institut de l’appareil locomoteur et de l’arthrite
INMD / INMD......................................Institute of Nutrition, Metabolism, and Diabetes / Institut de la nutrition, du métabolisme et
du diabète
INMHA / INSMT..................................Institute of Neurosciences, Mental Health, and Addiction / Institut des neurosciences, de la santé
mentale et des toxicomanies
IPPH / ISPP...........................................Institute of Population and Public Health / Institut de la santé publique et des populations
KFOC / FCR.........................................The Kidney Foundation of Canada / Fondation canadienne du rein
QLA / APQ...........................................Quebec Lung Association / Association pulmonaire du Québec
MSFHR..................................................Michael Smith Foundation for Health Research
NCIC / INCC........................................National Cancer Institute of Canada / Institut national du cancer du Canada
NHLBI...................................................National Heart Lung and Blood Institute
Pfizer.....................................................Pfizer Canada Inc.
SCN / RCS............................................Stem Cell Network / Réseau de cellules souches
Tekes.....................................................Finnish Funding Agency for Technology and Innovation
*In some cases, the official organization name exists in English only.
*Dans certains cas, le nom officiel de l’organisation n’existe qu’en anglais.
Explanatory Notes
Notes explicatives
1. The year following the initiative title indicates the year in which
funding began for the initiative.
1. L’année inscrite à la suite du titre de l’initiative indique l’année
à laquelle débute le financement de cette initiative.
2. Not all projects listed received funding directly from HSF. In
certain initiatives HSF is recognized as a partner for all projects
funded within an overall initiative (HSF funds are directed to one
or two projects).
2. Les projets mentionnés dans cette liste n’ont pas tous été
financés directement par la FMC. Pour certaines initiatives, la
FMC est reconnue comme étant un partenaire de tous les projets
financés dans le cadre de cette initiative globale (les fonds de la
FMC sont dirigés vers un ou deux projets).
33
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
NEW INITIATIVES
INITIATIVES NOUVELLES
Cardiovascular Complications of Diabetes 2007
Partners: ICRH, CDA, IAPH, III, INMD, HSF, Pfizer, Tekes, HC
Total Initiative Funding: $9,381,233
HSF Total Initiative Funding: $650,000
Complications cardiovasculaires du diabète 2007
Partenaires : ISCR, ACD, ISA, IMII, INMD, FMC, Pfizer, Tekes, SC
Financement total de l’initiative : 9 381 233 $
Financement total de l’initiative par la FMC : 650 000 $
Description: The program emphasis is on the production of
new knowledge, and the translation of research findings into
improvements in the health of populations and health care
systems at the interface between diabetes and the cardiovascular
research communities.
Description : Ce programme met l’accent sur la production
de nouvelles connaissances et la conversion des résultats de
recherche en améliorations de la santé des populations et des
systèmes de soins de santé dans le champ d’intérêt commun
aux milieux de recherche sur le diabète et sur les maladies
cardiovasculaires.
Cardiovascular Complications of Diabetes 2007 High Risk Seed Grants
Complications cardiovasculaires du diabète 2007 Subventions de démarrage à risque élevé
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s) Term
06-07 $
Co-chercheur(s)
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $* Total $* (All
HSF
Partners)
FMC
(tous les
partenaires)
Theme
Thème
Moody,
Alan
Sunnybrook In vivo detection of early diabetic
Health
vessel wall disease - a possible
Sciences
role for the RAGE-AGE-RBCCentre
Endothelial (RARE) complex at the
micro- and macrovascular levels.
Ontario:
Burns, Peter N;
Silverberg, Jay;
Tobe, Sheldon W
20072009
$25,000
$47,246 $75,000
$273,246
II
Moreau,
Pierre;
Mathieu,
Patrick
Université
de
Montréal
Québec: Poirier,
Paul; Pibarot,
Philippe; Voisine,
Pierre
20072009
$25,000
$54,167 $75,000
$300,000
I
Total $* (All
Partners)
(tous les
partenaires)
Protein gamma carboxylation in
diabetes: protential therapeutic
avenue for cardiovascular
calcification.
Cardiovascular Complications of Diabetes 2007 Team Grants
Complications cardiovasculaires du diabète 2007 Subventions d’équipe
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $ Total 06-07 $ Total $*
Durée HSF
(All Partners) HSF
FMC
(tous les
FMC
partenaires)
Petrella,
Robert J
Innovation to reduce cardiovascular complications of
diabetes at the intersection
of discovery, prevention and
knowledge exchange.
Ontario: Holdsworth,
David W; Shoemaker, J
Kevin ; Stewart, Moira;
Harris, Stewart B; Finland:
Tikkanen, Heikki
20072012
London
Health
Sciences
Centre
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
34
$33,333
$199,800 $500,000
$2,799,530
Theme
Thème
I
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Built Environment, Obesity and Health Development
Grants 2007
Partners: N/A
Total Initiative Funding: $40,896
HSF Total Initiative Funding: $40,896
Environnement bâti, obésité et santé 2007
Partenaires : S/O
Financement total de l’initiative : 40 896 $
Financement total de l’initiative par la FMC : 40 896 $
Description: Sixteen development grants (up to $5,000 each) were
awarded following the review of the Letter of Intent stage of the
Built Environment, Obesity and Health Request for Applications
(RFA). The funding was used to enable multidisciplinary and
geographically diverse teams to come together to plan their
research project and to prepare their full application.
Description : Seize bourses de développement (jusqu’à 5 000
dollars chacune) ont été décernées après l’étape de l’étude
de la lettre d’intention de la demande de propositions sur
l’Environnement bâti, l’obésité et la santé ADD. Ces fonds ont
servi à permettre aux équipes multidisciplinaires et réparties
géographiquement de se réunir afin de planifier leur projet
de recherche et de préparer leur demande complète en vue
du concours.
Reducing Health Disparities and Promoting Equity for
Vulnerable Populations - Interdisciplinary Capacity Enhancement
(ICE) Grants 2006
Partners: IGH, IPPH, IA, IAPH, ICR, ICRH, IHSPR, IHDCYH, III,
INMHA, INMD, CIHR - Ethics, CIHR - KT, CIHR - HIV/AIDS, CIHR
- GHRI, HSF
Total Initiative Funding: $14,574,019
HSF Total Initiative Funding: $249,755
Réduire les disparités sur le plan de la santé et promouvoir
l’équité pour les populations vulnérables - Subvention à
l’amélioration de la capacité interdisciplinaire (ACI) 2006
Partenaires : ISFH, ISPP, IV, ISA, IC, ISCR, ISPS, IDSEA, IMII,
INSMT, INMD, IRSC Éthique, IRSC-AC, IRSC VIH/sida,
IRSC-IRSM, FMC
Financement total de l’initiative : 14 574 019 $
Financement total de l’initiative par la FMC : 249 755 $
Description: The purpose of the Interdisciplinary Capacity
Enhancement (ICE) grant program is to provide support for
new or existing groups conducting multi-disciplinary research
on themes that align with this strategic initiative. The grants will
enable teams to build capacity and add expertise to their core
capacities and develop strategies for knowledge translation. It is
expected that this targeted investment will lead to understanding
and addressing health disparities, and improving the health
status of vulnerable populations.
Description : L’objectif du programme de subvention à
l’amélioration de la capacité interdisciplinaire (ACI) consiste à offrir
du soutien aux équipes nouvelles ou déjà formées, qui mènent des
recherches multidisciplinaires sur des thèmes conformes à cette
initiative stratégique. Ces subventions permettent aux équipes
de développer leur capacité et d’ajouter de l’expertise à leurs
compétences de base, afin d’élaborer des stratégies de
transfert des connaissances. On s’attend à ce que cet
investissement ciblé permette de comprendre et de résoudre
les inégalités en matière de santé et d’améliorer l’état de santé
des populations vulnérables.
Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Grants 2006
Réduire les disparités sur le plan de la santé et promouvoir l’équité pour les populations vulnerable - Subventions aux équipes
interdisciplinaires de renforcement des capacités (EIRC) 2006
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Grace,
Sherry L;
Stewart,
Donna E
Cardiovascular secondary
prevention for vulnerable
populations: an
interdisciplinary approach
to improving access to
services and outcomes.
Ontario: Alter, David A;
Anand, Sonia S; Bunker,
Steve; Harvey, Paula J;
Holder, Glenn; Kaur,
Rimmy; Oh, Paul; Rukholm,
Ellen E; Rush, James Walter
E; Scholey, Patricia E;
Williamson, Karen M
20062011
University
Health
Network
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
$49,755
III: Health Services/Systems
III : Services et systèmes de santé
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$148,387 $249,755
Total $* (All
Partners)
(tous les
partenaires)
$704,792
Theme
Thème
III
IV: Population Health
IV : Santé de la population
35
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 5 2006
Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D
Total Initiative Funding: $1,207,917
HSF Total Initiative Funding: $298,661
Opération AVC 5 2006
Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D
des IRSC
Financement total de l’initiative : 1 207 917 $
Financement total de l’initiative par la FMC : 298 661 $
Description: This initiative, led by HSF, supports doctoral research
awards, postdoctoral fellowships and new investigator awards
in the area of stroke. These funds help build greater capacity for
stroke research in Canada.
Description : Cette initiative menée par la FMC soutient des
bourses de recherche au doctorat, des bourses de recherche
postdoctorale et des bourses aux nouveaux chercheurs dans le
domaine des AVC. Ces fonds contribuent à accroître la capacité
de recherche sur les AVC au Canada.
Focus on Stroke 5 2006 Postdoctoral Fellowships
Opération AVC 5 2006 Bourses de recherche postdoctorale
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Ander,
Bradley P
University of
California
Protection against delayed daSharp, Frank R
mage of intracerebral hemorrhage
through inhibition of Src kinase.
20062008
$18,667
$33,334
$50,400
$90,000
I
Buck, Brian
H
Sunnybrook
Health
Sciences
Centre
Carotid atheroma treated with
aggressive lipid management
assessed by magnetic resonance
imaging (CALM-MR).
Saver, Jeffrey L
20052007
$30,800
$55,000
$33,133
$59,167
I, II
Gliddon,
St. Boniface
Catherine M G.H. Research
Centre
The role of PARP in a model of
cerebral ischemia.
Anderson,
Christopher M
20062008
$1,520
$45,000
$3,040
$90,000
I
Gorbet,
Diana J
University of
Waterloo
Sex-related differences in human
visuomotor control: implications
for stroke recovery.
Staines, W
Richard
20062008
$8,333
$35,000
$21,429
$90,000
I, II
Honoré,
JeanClaude
Hôpital
Sainte-Justine
Pro-survival role of the
peroxidation products isofurans
on cerebral microvascular
endothelial cells.
Chemtob, Sylvain
20062008
$5,952
$25,000
$21,429
$90,000
I
MacIntosh,
Bradley J
John Radcliffe
Hospital
Investigating neurovascular
Matthews, Paul M
coupling in the stroke brain using
functional imaging techniques.
20062008
$14,000
$25,000
$50,400
$90,000
I, II, III
McKay,
Catherine
Michelle
University of
Calgary
Endothelial ion channels in a
rat model of subarachnoid
hemorrhagic stroke.
Cole, William C
20072009
$3,571
$15,000
$21,429
$90,000
I
Spencer,
Sarah J
University of
Calgary
Does a neonatal immune
challenge affect emotional
processing after adult stroke?
Pittman, Quentin J
20062007
$1,520
$45,000
$1,520
$45,000
I
Wetzel,
Monica K
Hospital for
Sick Children
Elucidating the role of p63
in excitotoxic and ischemiainduced neuronal death.
Miller, Freda D
20062008
$1,520
$45,000
$3,040
$90,000
I
Ye, Hui
Toronto
Western
Research
Institute
Rescue synaptic transmission
deficit in aged/Alzheimer’s
disease.
Carlen, Peter L
20062008
$320
$45,000
$640
$90,000
I, II
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
36
Co-Investigator(s) Term
Co-chercheur(s)
Durée
06-07 $ Total 06-07 $ Total $*
HSF
(All Partners) HSF
FMC
(tous les
FMC
partenaires)
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 5 2006 Doctoral Research Awards
Opération AVC 5 2006 Bourses de recherche au doctorat
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Term 06-07 $
Durée HSF
FMC
Auriat,
Angela M
University
of Alberta
Mechanisms of rehabilitation therapy
following stroke.
Colbourne,
Frederick
20062009
$4,404
Christie,
Tara L
University Identifying the role and molecular
of Calgary mechanism of PlexinD1 in vascular
malformation.
Childs,
Sarah J
20062008
FreitasAndrade,
Moises
National
Role of placental growth factor in
Research hypoxia-induced brain angiogenesis.
Council of
Canada
(Ottawa)
Stanimivoric,
Danica
Ge, Yuan
University
of British
Columbia
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
$18,500
$15,714
$66,000
I
$5,238
$22,000
$10,476
$44,000
I
20062009
$4,821
$20,250
$15,714
$66,000
I
Wang, Yu
Tian
20062008
$5,238
$22,000
$10,476
$44,000
I, II
Green,
Theresa L
University Minor stroke transitions and marital
of Calgary dyad function in the early postdischarge period.
King,
Kathryn M
20062007
$3,571
$15,000
$3,571
Luykenaar,
Kevin D
University PKA/PKG regulation of RhoAof Calgary mediated inhibition of the delayed
rectifier potassium current in cerebral
arteries.
Welsh,
Donald G
20062008
$5,238
$22,000
$10,476
$44,000
I
Pereira,
Jennifer A
University Validation and implementation of
of Toronto individualized benefit: harm profiles
for optimal Warfarin prescribing.
Holbrook,
Anne M
20062007
$5,238
$22,000
$5,238
$22,000
II, IV
Qiu,
Guosong
St. Paul’s
Hospital
Lipase function in human macrophages.
Hill, John S
20062007
$5,238
$22,000
$5,238
$22,000
I
Silasi,
Gergely
University
of Alberta
Improving stroke outcome through
growth-factor induced recruitment of
endogenous stem cells.
Colbourne,
Frederick
20062009
$5,238
$22,000
$15,714
$66,000
I
Modulation of AMPA receptor
trafficking in the animal model
of stroke.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Total 06-07 $
(All Partners)
(tous les
partenaires)
III: Health Services/Systems
III : Services et systèmes de santé
Theme
Thème
$15,000 II, III, IV
IV: Population Health
IV : Santé de la population
37
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
CONTINUING INITIATIVES
INITIATIVES EN COURS
Programs of Research
Programmes de recherche
Childhood Obesity Operating Grants 2005
Partners: HSF, INMD, IHDCYH
Total Initiative Funding: $2,540,393
HSF Total Initiative Funding: $601,420
Bourses de fonctionnement en obésité chez les enfants 2005
Partenaires : FMC, INMD, IDSEA
Financement total de l’initiative : 2 540 393 $
Financement total de l’initiative par la FMC : 601 420 $
Description: The scope of research covered by this request for
applications encompasses healthy body weight and obesity in
childhood. This includes development, prevention, intervention,
and outcomes associated with healthy body weight and obesity
in children; spanning pre-conception and gestation through to
maturity; across all four of CIHR’s research themes. A total of 52
applications were submitted to the Childhood Obesity program
launched in June 2004. Thirteen applications were approved for
funding, seven of which were operating grants. Of these seven,
HSF supported four.
Description : La portée des recherches couvertes par cet appel
de demandes couvre le poids santé et l’obésité chez les enfants.
On y retrouve le développement, la prévention, l’intervention et
les résultats associés au poids santé et à l’obésité chez les enfants
de la préconception et de la gestation à la maturité, sur les quatre
thèmes de la recherche au sein des IRSC. En tout, 52 demandes
ont été soumises au programme d’obésité chez les enfants depuis
son lancement en juin 2004. Treize demandes ont été approuvées
pour recevoir du financement, dont sept sous forme de fonds
de fonctionnement. Parmi ces sept demandes, quatre étaient
financées par la FMC.
Childhood Obesity Operating Grants 2005
Bourses de fonctionnement en obésité chez les enfants 2005
Principal
Investigator
Chercheur
principal
Institute
Institut
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
He, Meizi
University
of Western
Ontario
Childhood overweight and
obesity management:
physicians’ views, practices,
perceived barriers and needs.
Ontario: Clarson,
Cheril L; Harris,
Stewart B; Piche,
Leonard
20062008
$26,808
$48,634
$86,608
$173,218
III
Morrison,
Katherine M
McMaster
University
Cardiovascular risk factors,
glucose metabolism and
intramyocellular lipid in
children with obesity at
baseline and after a pediatric
obesity treatment program.
Ontario: Atkinson,
Stephanie A;
Bar-Or, Oded;
Tarnopolsky, Mark;
Yusuf, Salim
20052008
$99,255
$198,510
$289,965
$579,931
II
Naylor, PattiJean
University
of British
Columbia
Evaluating the effectiveness
of the dissemination of Action
Schools! BC: a socio-ecological
intervention to increase
physical activity and healthy
eating in school children
British Columbia:
McKay, Heather
A; Rhodes, Ryan
E; Wharf Higgins,
Joan; Ontario:
Manske, Stephen R
20052008
$66,000
$200,000
$200,000
$600,000
IV
Stewart,
Jennifer M
Carleton
University
Maternal employment and
childhood obesity.
Federal: Chowhan,
James
20062008
$10,870
$19,670
$24,847
$49,695
IV
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
38
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Genomic Medicine and Human Development 2005
Partners: HSF, ICRH, IG, IHDCYH
HSF Total Initiative Funding: $600,000
Médecine génomique et développement humain 2005
Partenaires : FMC, ISCR, IG, IDSEA
Financement total de l’initiative par la FMC : 600 000 $
Description: The purpose of this RFA is to provide operating grants
in support of projects that bridge clinical investigation and more
basic scientific research to address an important problem in human
development. HSF co-funded one project listed below.
Description : L’objectif de cet appel de candidatures consiste
à offrir des fonds de fonctionnement aux projets qui relient la
recherche clinique et la recherche scientifique fondamentale sur
le développement humain. La FMC co-finance un des projets
énumérés plus bas.
Genomic Medicine and Human Development 2005
Médecine génomique et développement humain 2005
Principal Investigator
Chercheur principal
Institute Project
Institut
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Andelfinger, Gregor U;
Nemer, Mona; Richter,
Andrea M; Rozen, Rima
Hôpital
SainteJustine
Québec: Bigras, JeanLuc; Dube, MariePierre; Khairy, Paul
20052010
Genetic determinants
of congenital heart
disease.
$120,000
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$465,262 $600,000
Total $*(All Theme
Partners)
Thème
(tous les
partenaires)
$2,382,246
I,II,IV
Subventions à la santé et à la démence vasculaires 2005
Partenaires : FMC, SAC, INSMT, IV, programme Rx&D des IRSC,
Pfizer
Financement total de l’initiative : 1 297 343 $
Financement total de l’initiative par la FMC : 432 448 $
Vascular Health and Dementia Operating Grants 2005
Partners: HSF, ASC, INMHA, IA, CIHR/Rx&D, Pfizer
Total Initiative Funding: $1,297,343
HSF Total Initiative Funding: $432,448
Description: The objective of this HSF-led initiative is to support
research that explores the interrelationships between vascular
health, vascular dementia and Alzheimer disease. Two competitions
were launched in this area, in 2004 and again in 2005.
Vascular Health and Dementia Operating Grants 2005
Subventions à la santé et à la démence vasculaires 2005
Description : L’objectif de cette initiative conduite par la FMC
consiste à soutenir la recherche portant sur les interrelations entre
la santé vasculaire, la démence vasculaire et la maladie d’Alzheimer.
Deux concours ont été lancés en ce domaine en 2004 et de
nouveau en 2005.
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Belleville,
Sylvie
Institut
Universitaire
de Gériatrie
de Montréal
Impact of vascular
dementia, vascular MCI
and vascular health on
cognition.
Québec: Gauthier, Serge
G; Massoud, Fadi
20052008
$17,669
$111,425 $114,131
$342,393
II
Black,
Sandra
Sunnybrook
Health
Sciences
Centre
In vivo characterization
of subcortical vascular
cognitive impairment
using advanced high
field MR techniques.
Ontario: Graham, Simon
J; Lobaugh, Nancy J;
Moody, Alan; Sahlas,
Demetrios J; Stanisz,
Greg J; Stuss, Donald T
20052008
$20,016
$120,000 $119,953
$359,860
I, II
>>
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
39
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
Darvesh,
Sultan
Dalhousie
University
The cholinergic system
and vascular risk factors
in Alzheimer’s disease
and vascular dementia.
Nova Scotia: Hopkins,
Daivd A; Rockwood,
Kenneth J
20052008
$16,782
Yu, Peter H
University of Is increased SSAOSaskatchewan: D’Arcy, K
Saskatchewan mediated oxidative
Carl R; Pahwa, Punam
deamination a risk factor
for vascular dementia
and Alzheimer’s disease?
A biosocial investigation.
20052008
$16,272
Vascular Health and Dementia Operating Grants 2004
Partners: HSF, ASC, INMHA, IA, CIHR/Rx&D, Pfizer
Total Initiative Funding: $1,262,100
HSF Total Initiative Funding: $420,300
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$100,721 $100,734
$97,630
$97,629
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
$302,203
I
$292,887
I. IV
Subventions à la santé et à la démence vasculaires 2004
Partenaires : FMC, SAC, INSMT, IV, programme Rx&D des IRSC,
Pfizer
Financement total de l’initiative : 1 262 100 $
Financement total de l’initiative par la FMC : 420 300 $
Vascular Health and Dementia Operating Grants 2004
Subventions à la santé et à la démence vasculaires 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Boulay,
Guylain
Université de
Sherbrooke
Intracellular calcium
signaling and vascular
Québec: Guillemette,
Gaetan
20042007
$35,175
$70,275
$93,600
$281,400
I
Carlen,
Peter
Toronto
Western
Research
Institute
Alzheimer’s disease,
aging and the
ischemic synapse.
None
20042007
$44,325
$88,650 $115,500
$346,700
I
Corbett,
Dale R
Memorial
University of
Newfoundland
Exercise, aging and
cognitive impairment.
Manitoba: Peeling, James;
Newfoundland: Harley,
Carolyn; Moody-Corbett,
Frances L
20042007
$45,000
$90,000 $119,900
$360,000
I
Zhang,
Wandong
National
Research
Council of
Canada
Neurovascular Unit in
Alzheimer’s disease
and cerebral amyloid
angiopathy.
Ontario: Yan Liu, Qing;
Stanimirovic, Danica B;
Woulfe, John
20052008
$36,225
$72,375
$274,000
I
dementia.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
40
$91,300
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Addressing Health Care & Health Policy Challenges of Genetic
Medicine 2004
Partners: IG, IHSPR, IPPH, CCOHTA, HSF, FPT Task Group on
Genomics and Health
Total Initiative Funding: $2,568,037
HSF Total Initiative Funding: $150,000
Relever les défis des soins et des politiques de santé de la
médecine génétique 2004
Partenaires : IG, ISPS, ISPP, OCCETS, FMC, Groupe de travail FPT
sur la génomique et la santé
Financement total de l’initiative : 2 568 037 $
Financement total de l’initiative par la FMC : 150 000 $
Description: The program was designed to provide operating
grant funds in support of research projects, the results of which
will better equip health care providers, administrators and policy
makers to improve the health of populations and strengthen the
health care system in Canada in the face of the rapid growth in new
technologies and understandings associated with the “genetics
era”. Two projects were funded through this initiative; HSF directly
supported one project.
Description : Ce programme a été conçu afin de fournir des
fonds de fonctionnement à des projets de recherche, dont les
résultats serviront à mieux équiper les professionnels de la santé,
les administrateurs et les décideurs dans le but d’améliorer la
santé des populations et de renforcer le système de santé du
Canada face à la croissance rapide des nouvelles technologies et
des notions d’« ère de la génétique ». Deux projets ont reçu du
financement par l’entremise de cette initiative. La FMC finançait
directement un de ces projets.
Addressing Health Care & Health Policy Challenges of Genetic Medicine 2004
Relever les défis des soins et des politiques de santé de la médecine génétique 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Rousseau,
Francois
Project
Projet
Université Health care and
Laval
health policy
challenges in
genetic
laboratory
services.
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
British Columbia: Friedman,
Jan; Québec: Battista, Renaldo;
Blancquaert, Ingeborg Rose;
Drouin, Régen; Forest, Jean
Claude; Foulkes, William;
Giguere, Yves; Godard, Beatrice;
Labrecque, Michel; Laflamme,
Nathalie; Lamarche, MarieChristine; Lamothe, Lise; Landry,
Réjean; Legare, France; Marra,
Carlo; Reinharz, Daniel
20042007
Total 06-07 $
(All Partners)
(tous les
partenaires)
$50,000
$715,363
Total $*
HSF
FMC
$150,000
Total $* (All
Partners)
(tous les
partenaires)
$2,098,210
Theme
Thème
III
Inflammation and Thrombosis 2004
Partners: HSF, ICRH, NHLBI
Total Initiative Funding: $761,596
HSF Total Initiative Funding: $260,000
Inflammation et thrombose 2004
Partenaires : FMC, ISCR, NHLBI
Financement total de l’initiative : 761 596 $
Financement total de l’initiative par la FMC : 260 000 $
Description: The program provides support for research on the
interplay between inflammation and thrombosis, and encourages
translational and pre-clinical studies for the development of anticoagulation agents for better management of thrombotic disorders.
Description : Ce programme offre du soutien à la recherche sur
les interactions entre l’inflammation et la thrombose et encourage
les études de translation et précliniques sur le développement
d’agents anticoagulants permettant de mieux contrôler les
troubles thrombotiques.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
41
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Inflammation and Thrombosis 2004
Inflammation et thrombose 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Bajzar,
Laszlo
Project
Projet
University Carboxypeptidases in
of Alberta thrombosis and inflammation.
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
None
20032008
Total 06-07 $
(All Partners)
(tous les
partenaires)
$65,000
Total $*
HSF
FMC
$182,274 $260,000
Total $* (All
Partners)
(tous les
partenaires)
$761,596
Theme
Thème
I
Molecular and Cellular Imaging 2004
Partners: HSF, ICRH, NHLBI
Total Initiative Funding: $2,145,500
HSF Total Initiative Funding: $260,000
Imagerie moléculaire et cellulaire 2004
Partenaires : FMC, ISCR, NHLBI
Financement total de l’initiative : 2 145 500 $
Financement total de l’initiative par la FMC : 260 000 $
Description: Multidisciplinary approaches are needed to address
technical challenges associated with imaging the heart, lung, and
blood systems, especially at the cellular and molecular level in
vivo. The objectives of this initiative are: to develop novel noninvasive cellular and molecular probes to image specific cellular
or molecular targets and events in the cardiovascular, pulmonary,
and hematopoietic systems in vivo; and to develop novel imaging
techniques or adapt current imaging technologies to utilize these
probes to image the cardiovascular, pulmonary, and blood systems
at the cellular or molecular level.
Description : Des approches multidisciplinaires sont nécessaires
pour faire face aux défis techniques associés à l’imagerie du
cœur, des poumons et du système circulatoire, surtout au niveau
cellulaire et moléculaire in vivo. Les objectifs de cette initiative
sont les suivants : développer de nouvelles méthodes de sondage
non invasives destinées à l’imagerie cellulaire et moléculaire
spécifique et l’activité des systèmes cardiovasculaire, pulmonaire
et hématopoïétique in vivo, ainsi que développer de nouvelles
techniques d’imagerie ou d’adapter des technologies existantes
afin de les utiliser dans l’imagerie cardiovasculaire, pulmonaire et
circulatoire au niveau cellulaire et moléculaire.
Molecular and Cellular Imaging 2004
Imagerie moléculaire et cellulaire 2004
Principal
Investigator
Chercheur
principal
Institute
Institut
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Cloutier, Guy
HôtelDieu de
Cellular imaging
of blood flow
rheological
disorders.
Québec: Trudel, Marie; USA:
Armstrong, Jonathan K;
Fisher, Timothy C; Meiselman,
Herbert J
20032008
$32,500
$270,465 $130,000
$1,081,860
I
MR imaging of
myeloperoxidase
activity.
Ontario: Bowen, Chris;
Hegele, Robert A; Huff,
Murray W;Pickering, J
Geoffrey; Rogers, Kem A;
USA: Bogdanov, Alexei
A; Jaffer, Farouc Amin;
Josephson, Lee; Libby, Peter;
Perez, J Manuel
20032008
$32,500
265910 $130,000
$1,063,640
I
Montréal
Rutt, Brian
K (Canadian
Lead);
Weissleder,
Ralph (American
Lead)
Robarts
Research
Institute;
Harvard
Medical
School
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
42
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Obesity New Emerging Teams (NET) 2004
Partners: HSF, INMD
Total Initiative Funding: $2,999,776
HSF Total Initiative Funding: $1,000,000
Équipes en voie de formation sur l’obésité (EVF) 2004
Partenaires : FMC, INMD
Financement total de l’initiative : 2 999 776 $
Financement total de l’initiative par la FMC : 1 000 000 $
Description: The New Emerging Team Grant is intended to
promote the formation of new and previously nonexistent research
teams or the growth of small existing teams of researchers in the
area of obesity/healthy body weight.
Description : La subvention aux équipes en voie de formation est
destinée à promouvoir la formation de nouvelles équipes de recherche
auparavant inexistantes ou la croissance de petites équipes déjà
formées de chercheurs dans le domaine de l’obésité et du poids santé.
Obesity New Emerging Teams (NET) 2004
Équipes en voie de formation sur l’obésité (EVF) 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
Durée
06-07 $
HSF
FMC
Katzmarzyk,
Peter T
Queen’s
University
Understanding the
individual and socioenvironmental health
risks of obesity: The
Canadian Heart Health
Surveys follow-up study.
Lambert,
Marie
Hôpital
SainteJustine
Familial study on
the prevention of
cardiovascular disease
and type 2 diabetes in
children and adolescents.
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Alberta: Raine, Kim D; Nova
Scotia: Joffres, Michel R;
MacLean, David R; Ontario:
Elliot, Susan; Saskatchewan:
Pahwa, Punam; Reeder,
Bruce
20042010
$100,000
$300,000 $500,000
$1,500,000
IV
Québec: O’Loughlin,
Jennifer Lee; Tremblay,
Angelo; Gray-Donald,
Katherine; Hanley, James
A; Levy, Emile EH; Paradis,
Gilles; Poirier, Paul
20042010
$100,000
$299,944 $500,000
$1,499,776
II
Obesity New Emerging Teams (NET) 2003
Partners: HSF, CIHR
Total Initiative Funding: $3,000,000
HSF Total Initiative Funding: $1,000,000
Équipes en voie de formation sur l’obésité (EVF) 2003
Partenaires : FMC, IRSC
Financement total de l’initiative : 3 000 000 $
Financement total de l’initiative par la FMC : 1 000 000 $
Description: Through the HSF Research Fund, the Foundation
partnered with INMD to support two NET programs – designed
to promote the formation of new and previously nonexistent
research teams or the growth of small existing teams of
researchers in the area of obesity/healthy body weight.
Description : Par l’entremise du Fonds de recherche de la
Fondation des maladies du cœur, la Fondation s’est associée à
l’INMD pour financer deux programmes EVF, destinés à promouvoir la formation de nouvelles équipes de recherche auparavant
inexistantes ou la croissance de petites équipes déjà formées de
chercheurs dans le domaine de l’obésité et du poids santé.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
43
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Obesity New Emerging Teams (NET) 2003
Équipes en voie de formation sur l’obésité (EVF) 2003
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
Durée
06-07 $
HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Raine, Kim
University An ecological
of Alberta perspective on
the promotion of
healthy weights.
Alberta: Church, William;
McCargar, Linda; Plotnikoff,
Ronald C; Wild, T Cameron
20032008
$100,000
$300,000 $500,000
$1,500,000
IV
Sharma,
Arya Mitra
Hamilton
General
Hospital
Ontario: Anand, Sonia S; Austin,
Richard C; Weitz, Jeffrey I; Yusuf,
Salim
20032008
$100,000
$300,000 $500,000
$1,500,000
I, II
Obesity and
atherothrombosis.
Palliative / End of Life Care 2004
Partners: ACB, BCCA, CCMB, IA, ICR, ICRH, IGH, IHSPR,
IHDCYH, INMHA, CIHR-KT, HSF
Total Initiative Funding: $12,145,811
HSF Total Initiative Funding: $662,800
Soins palliatifs et de fin de vie 2004
Partenaires : ACB, BCCA, CCMB, IV, IC, ISCR, ISFH, ISPS, IDSEA,
INSMT, IRSC-AC, FMC
Financement total de l’initiative : 12 145 811 $
Financement total de l’initiative par la FMC : 662 800 $
Description: New Emerging Team grants are intended to support
the creation or development of teams comprised of investigators
undertaking collaborative, multidisciplinary research. The program
is designed to promote the formation of new research teams or
the growth of small existing teams of researchers in the area of
palliative and end of life care. HSF’s primary focus was on
communication between family and health care providers at
end of life. One project was funded within this focus area. Nine
projects were funded in total ranging from “End of life care and
vulnerable populations” to “Transitions in pediatric palliative
and end of life care”.
Description : Les subventions aux équipes en voie de formation
sont destinées à soutenir la création ou le développement
d’équipes composées de chercheurs impliqués dans des recherches collaboratives et multidisciplinaires. Le programme est conçu
dans le but de promouvoir la formation de nouvelles équipes de
recherche ou la croissance de petites équipes de recherche déjà en
place dans le domaine des soins palliatifs et de fin de vie. L’objectif
premier de la FMC est la communication entre la famille et les
professionnels de la santé en fin de vie. Un projet a reçu du financement dans ce domaine. Neuf projets variant de « Soins de fin de vie
chez les populations vulnérables » à « Transitions en soins palliatifs
et de fin de vie pédiatriques » ont reçu une aide financière.
Palliative / End of Life Care 2004
Soins palliatifs et de fin de vie 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Heyland,
Daren K
Project
Projet
Queen’s Understanding and
University improving communication and decisionmaking at the end of life.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
44
Co-Investigator(s)
Co-chercheur(s)
British Columbia: Kuhl, David
R; Ontario: Cook, Deborah
J; Gafni, Amiram; Giacomini,
Mita; Tranmer, Joan E
Term
Durée
20042010
06-07 $
HSF
FMC
$150,000
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$263,531 $662,800
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
$1,325,641
III
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Regenerative Medicine 2004
Partners: CIHR, INMHA, IG, ICRH, IMHA, HSF, SCN
Total Initiative Funding: $12,000,000
HSF Total Project Funding: $500,000
Médecine régénérative 2004
Partenaires : IRSC, INSMT, IG, ISCR, IALA, FMC, SCN
Financement total de l’initiative : 12 000 000 $
Financement total du projet par la FMC : 500 000 $
Description: The June 2003 RFA offered support for innovative
research projects in the areas of Nanotechnology Development
and Nanomedicine, Stem Cells, and Tissue Engineering. This
support was provided through innovative Pilot Project Grants,
New Emerging Teams (NET) Grants, and Interdisciplinary
Capacity Enhancement (ICE) Teams Grants. HSF provided
funding to one of eight NET Grants funded under this initiative.
Description : L’appel aux candidatures de juin 2003 a offert du
soutien aux projets de recherche innovateurs dans les domaines
du développement des nanotechnologies et de la nanomédecine, des cellules souches et du génie tissulaire. Ce soutien a été
offert par l’entremise des subventions aux projets pilotes, des
subventions aux équipes en voie de formation et des subventions
d’équipes d’amélioration de la capacité interdisciplinaire, des
programmes innovateurs. La FMC a financé un des huit projets
ayant reçu une subvention EVF dans le cadre de cette initiative.
Regenerative Medicine 2004
Médecine régénérative 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
Galipeau,
Jacques
Cardiovascular and
respiratory stem cell
plasticity - CARE project.
British Columbia: Lansdorp,
Peter Michael; Karsan,
Aly; Ontario: Liu, Peter P;
Stewart, Duncan John
20052010
Jewish
General
Hospital
$100,000
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
$300,000 $500,000
Total $* (All
Partners)
(tous les
partenaires)
$1,500,000
Theme
Thème
I
Resuscitation Outcomes Consortium 2004
Partners: HSF, ICRH, NHLBI
Total Initiative Funding: $4,127,712
HSF Total Initiative Funding: $650,000
Consortium sur les résultats de la réanimation 2004
Partenaires : FMC, IRSC, NHLBI
Financement total de l’initiative : 4 127 712 $
Financement total de l’initiative par la FMC : 650 000 $
Description: The Program provides support for the establishment
of a Resuscitation Outcomes Consortium (ROC) to conduct
clinical research in the areas of cardiopulmonary arrest and
traumatic injury leading to arrest. The ROC, consisting of ten
Regional Clinical Centers (RCCs) and a Data and Coordinating
Centre (DCC), will provide the necessary infrastructure to conduct
multiple collaborative trials to aid rapid translation of promising
scientific and clinical advances to improve resuscitation outcomes.
Description : Le programme offre du soutien à la mise sur pied
d’un Consortium sur les résultats de la réanimation (CRR) afin
de mener des études cliniques dans le domaine de l’arrêt cardiorespiratoire et des blessures traumatiques entraînant cet arrêt.
Le Consortium, qui comprend dix Centres cliniques régionaux
(CCR) et un Centre de données et de coordination (CDC)
offre l’infrastructure nécessaire pour la réalisation d’études
collaboratives multiples destinées à aider la conversion rapide
des percées scientifiques et cliniques en amélioration des
résultats de la réanimation.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
45
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Resuscitation Outcomes Consortium 2004
Consortium sur les résultats de la réanimation 2004
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
Durée
06-07 $
HSF
FMC
Slutsky,
Arthur S
St.
Michael’s
Hospital
From bench to
bedside to
curbside.
Stiell, Ian
Ottawa
Health
Research
Institute
Proposal to
create a canadian
collaborative RCC.
Ontario: Black, Sandra E; Davis,
David; Dorian, Paul; Hutchison,
James S; Lavery, James; Morrison,
Laurie J; Redelmeier, Donald A;
Rotstein, Ori D; Sibbald, William
20042009
$65,000
$470,216 $325,000
$2,167,032
III
British Columbia: Abu-Laban,
Riyad B; Christenson, James M;
Levy, Adrian R; Macnab, Andrew
J; Russell, James A; Simons,
Richard K; Sun, Charles Y; Ontario:
Herbert, Paul C; Osmond, Martin
H; Vaillancourt, Christian; Wells,
George A
20042009
$65,000
$420,146 $325,000
$1,960,680
III
Sex, Gender & Cardiovascular Disease Interdisciplinary Capacity
Enhancement 2004
Partners: IGH, ICRH, HSF, CLA
Total Initiative Funding: $5,905,000
HSF Total Initiative Funding: $1,075,000
Description: This research capacity-building program helps
forge multidisciplinary teams around the three strategic research
themes (i.e., Gender and sex determinants of atherosclerotic
disease risks, including metabolic syndrome, across the lifespan;
Gender and sex determinants of acute coronary syndromes;
Gender and sex determinants of lung disease including airways
diseases and lung cancer) and attracts researchers from relevant
disciplines including those who have not been primarily or
previously involved in health research. Four teams were funded
through this initiative, with two receiving funding from HSF.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
46
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Amélioration de la capacité de recherche interdisciplinaire sur le
sexe social, le sexe biologique et les maladies cardiovasculaires
2004
Partenaires : ISFH, ISCR, FMC, APC
Financement total de l’initiative : 5 905 000 $
Financement total de l’initiative par la FMC : 1 075 000 $
Description : Ce programme de développement de la capacité
de recherche aide à former des équipes multidisciplinaires autour
de trois thèmes de recherche stratégique (p. ex., le sexe et les
variables sexuelles des risques de maladies athérosclérotiques tout
au long de la vie; le sexe et les variables sexuelles des syndromes
coronariens aigus; le sexe et les variables sexuelles des maladies
respiratoires comme les maladies des voies respiratoires et le
cancer du poumon), et attire des chercheurs de disciplines
pertinentes, dont ceux qui n’ont pas été principalement ou
auparavant associés à la recherche en santé. Quatre équipes ont
été financées par l’entremise de cette initiative, dont deux ont
reçu l’appui financier de la FMC.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Sex, Gender & Cardiovascular Disease Interdisciplinary Capacity Enhancement 2004
Amélioration de la capacité de recherche interdisciplinaire sur le sexe social, le sexe biologique et les maladies cardiovasculaires 2004
Awardee
Institute
Récipiendaire Institut
Project
Supervisor
Projet
Directeur
Term
06-07 $
Durée HSF
FMC
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Anand, Sonia
McMaster Sex and gender
University determinants of acute
coronary syndromes
and the metabolic
syndrome: Interdisciplinary Capacity
Enhancement (ICE)
teams grant program.
Ontario: Alter, David A;
Arthur, Heather M; Gerstein,
Hertzel C; Lonn, Eva M;
Mehta, Shamir; Natarajan,
Madhu K; Sharma, Arya
M; Yusuf, Salim; Germany:
Blankenberg, Stefan
20052010
$115,000
$300,000 $537,500
$1,476,251
IV
Pilote, Louise
McGill
University
Gender and sex
determinants of
cardiovascular disease:
Alberta: Ghali, William;
Norris, Colleen M; British
Columbia: Humphries, Karin
20052010
$115,000
$300,000 $537,500
$1,476,247
IV
from bench to beyond.
H; Nova Scotia: Cox, Jafna
L; Kirkland, Susan; Ontario:
Tu, Jack V; Québec:
Eisenberg, Mark J; Hamet,
Pavel; O’Loughlin, Jennifer
Lee; Tremblay, Johanne
ICRH/HSF New Emerging Teams (NET) 2003
Partners: HSF, ICRHTotal
Initiative Funding: $4,795,947
HSF Total Initiative Funding: $2,371,128
Équipes en voie de formation ISCR/FMC (EVF) 2003
Partenaires : FMC, ISCR
Financement total de l’initiative : 4 795 947 $
Financement total de l’initiative par la FMC : 2 371 128 $
Description: The purpose of this initiative is to build capacity in
new and developing areas of research; to build new research
teams; and to give researchers a building block for applying for
research funding in future years.
Description : Le but de cette initiative est de bâtir la capacité de
recherche dans des domaines nouveaux et émergents; de créer
de nouvelles équipes de chercheurs et d’offrir aux chercheurs une
pierre d’assise sur laquelle asseoir le financement de la recherche
au cours des prochaines années.
ICRH/HSF New Emerging Teams (NET) 2003
Équipes en voie de formation ISCR/FMC (EVF) 2003
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
Durée
06-07 $
HSF
FMC
Gutkowska,
Jolanta
Hôtel
Dieu de
Montréal
Development of cardiac
cell replacement /
regeneration therapies
based on cardiomyogenic
action of oxytocin.
Smith,
Graeme N
Queen’s
University
Pre-eclampsia: fetal and
maternal outcomes and
innovative therapies.
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Québec: Blaise, Gilbert A;
Jankowski, Marek; Paquin,
Joanne; Troncy, Eric TE
20032008
$154,000
$308,000 $770,000
$1,557,000
I, II
Ontario: Graham, Charles
H; Kisilevsky, Barbara;
MacDonald, Susan E;
Walker, Mark; Wen, Shi Wu
20032008
$172,354
$344,944 $860,889
$1,739,481
II
>>
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
47
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term
Durée
06-07 $
HSF
FMC
Tamblyn,
Robyn
E-Integration in the
management of respiratory and circulatory
disease: elucidating the
multi-level mechanism
that optimize population
outcomes.
Québec: Dubé, Laurette;
Emst, Pierre; Mayo, Nancy
E; Pinsonneault, Alain;
Verter, Vedat
20032008
$149,957
McGill
University
Chronic Disease New Emerging Teams (NET) 2002
Partners: HSF, CDA, KFOC, ICRH, INMD
Total Initiative Funding: $6,975,441
HSF Total Initiative Funding: $500,000
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$299,956 $740,239
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
$1,499,466
II, III
Équipes en voie de formation sur les maladies chroniques (EVF)
2002
Partenaires : FMC, ACD, FCR, ISCR, INMD
Financement total de l’initiative : 6 975 441 $
Financement total de l’initiative par la FMC : 500 000 $
Description: The objectives of this initiative are to: support
the creation of new competitive research teams, which show
potential for successfully applying for infrastructure team funding
in the future; support multidisciplinary and cross-theme research
in identified areas of focus; support the training and establishment of new investigators. HSF and its partners funded projects
focused on common and related aspects of kidney disease,
cardiovascular disease and diabetes. HSF partnered on all six
projects under the Chronic Disease NET initiative with our portion
of funds flowing directly to two of the six projects
Description : Les objectifs de cette initiative sont de : soutenir
la création de nouvelles équipes de recherche compétitives
qui affichent un potentiel de réussite pour des demandes de
financement des équipe d’infrastructure au cours des prochaines
années, de soutenir la recherche multidisciplinaire et transthématique dans des domaines d’intérêt déterminés et d’appuyer
la formation et l’établissement de nouveaux chercheurs. La FMCC
et ses partenaires ont financé des projets portant sur des aspects
communs et connexes des maladies rénales, des maladies
cardiovasculaires et du diabète. La FMCC a agi à titre de
partenaire dans le cadre des six projets regroupés sous le
parapluie des maladies chroniques et sa part de financement
est allée directement à deux de ces six projets.
Chronic Disease New Emerging Teams (NET) 2002
Équipes en voie de formation sur les maladies chroniques (EVF) 2002
Principal
Investigator
Chercheur
principal
Institute
Institut
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Anderson,
Geoffrey M (CoLead); Rochon,
Paula A (Co-Lead)
University
of Toronto
Pharmacological
management of
chronic disease in
older adults.
Ontario: Hux, Janet;
Laupacis, Andreas;
United States: Gurwitz,
Jerry H; Stukel, Therese
20022007
$0
Johnson, Jeffrey A
University
of Alberta
Establishment of the
allliance for Canadian
health outcomes
research in diabetes
(ACHORD) group.
Alberta: Ghali,
William; Jacobs, Philip;
Majumdar, Sumit; Toth,
Ellen L
20032008
$45,833
Lebel, Marcel
Hôtel
Dieu de
Québec
Cardiovascular health
in chronic renal
failure.
Québec: Agharazii,
Mohsen; Cléroux, Jean;
Isenring, Paul; Larivière,
Richard; Richard, Darren
E
20022007
$0
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
48
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
$0
$1,230,925
I, II, III
$177,553 $250,000
$908,600
II, III,
IV
$306,021
$250,000
$0
$1,250,000
I, II
>>
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal
Investigator
Chercheur
principal
Institute
Institut
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Nichol, Graham
(Co-Lead), O’Brien
Bernie (Co-Lead)
Ottawa
Heart
Institute,
McMaster
University
Cardiovascular
outcomes related
to economic (core)
group.
Alberta: Armstrong, Paul
W; Donaldson, Cameron;
Sheldon, Robert S;
Ontario: Wells, George A
20022007
$0
Parfrey, Patrick S
Health
Sciences
Centre, St.
John’s
Canadian collaborative group for the
prevention of illness
in chronic kidney
disease: the Canadian
prevention of renal
and cardiovascular
end-points trial.
British Columbia: Levin,
Adeera; Molzahn,
Anita E; Singer, Joel;
Manitoba: Rigatto,
Claudio; Newfoundland:
Barrett, Brendan;
Ontario: Churchill, David;
Gerstein, Hertzel C;
20022007
$45,833
20022007
$0
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
$214,161
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
$0
$1,141,608
II, III,
IV
$217,920 $250,000
$1,250,000
II, III
$305,190
$1,194,308
I, II, IV
Goeree, Ron
Scholey, James W
University
of Toronto
Gender/genes and
glomerular-based
diseases research
group.
Ontario: Beanlands,
Heather; Cattran, Daniel;
McCay, Elizabeth; Miller,
Judith A
$0
Gene-Environment Interactions Interdisciplinary Health
Research Teams (IHRTs) 2002
Partners: HSF, ICRH
Total Initiative Funding: $7,926,761
HSF Total Initiative Funding: $2,000,000
Équipes interdisciplinaires de recherche en santé (ÉIRS) sur les
interactions entre les gènes et l’environnement 2002
Partenaires : FMC, ISCR
Financement total de l’initiative : 7 926 761 $
Financement total de l’initiative par la FMC : 2 000 000 $
Description: This initiative focuses on the interplay between
genetic and environmental factors in the manifestation and
progression of circulatory and respiratory diseases and disorders.
The purpose of the Interdisciplinary Health Research Teams
(IHRT) program is to build collaborations among scientists working in the fields of population health epidemiology, environmental
health sciences, cell, molecular biology, biochemistry, physiology,
pathology, pharmacology, genomics, molecular diagnostics, and
biostatistics to plan innovative research programs that integrate
molecular and epidemiologic perspectives. The general purpose
of the collaboration is to elucidate critical research questions in
circulatory and respiratory diseases that cannot be addressed
within the confines of a single discipline. HSF partnered with
ICRH on all three projects although HSF funding only went
directly to one project.
Description : Cette initiative portait sur l’interaction entre les facteurs génétiques et environnementaux dans la manifestation
et la progression des maladies et troubles circulatoires et
respiratoires. L’objectif du programme des Équipes interdisciplinaires de recherche en santé (EIRS) consiste à établir des
liens de collaboration entre les chercheurs des domaines de
l’épidémiologie de la santé de la population, des sciences de la
santé environnementale, des cellules, de la biologie moléculaire,
de la biochimie, de la physiologie, de la pathologie, de la
pharmacologie, de la génomique, du diagnostic moléculaire et
de la biostatistique afin de planifier des programmes de recherche innovateurs intégrant les points de vue moléculaires et
épidémiologiques. L’objectif général de cette collaboration
consiste à élucider des questions scientifiques critiques au sujet
des maladies circulatoires et respiratoires auxquelles il est
impossible de répondre à l’intérieur des confins d’une discipline
unique. La FMC est partenaire des ISCR au sein des trois projets
de cette initiative, bien qu’une aide financière par la FMC n’ait
été accordée qu’à un seul de ces projets.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
49
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Gene-Environment Interactions Interdisciplinary Health Research Teams (IHRTs) 2002
Équipes interdisciplinaires de recherche en santé (ÉIRS) sur les interactions entre les gènes et l’environnement 2002
Principal
Institute
Investigator Institut
Chercheur
principal
Project
Projet
Co-Investigator(s)
Co-chercheur(s)
Term 06-07 $
Durée HSF
FMC
Hamet,
Pavel
Université Cardiogene:
de
a consortium
Montréal to explore the
nature of geneenvironment
interactions in
major cardiovascular disorders
using human
and animal
models; should
lead to targeted
therapeutic
and preventive
interventions in
cardiovascular
discorders.
Québec: Abrahamowicz,
Michal; Deng, Alan Y; FrasureSmith, Nancy; Gaudet, Daniel;
Lesperance, Francois; Merlo,
Ettore; Nattel, Stanley; Pausova,
Zdenka; Shatenstein, Bryna;
Siemiatycki, Jack; Skamene, Emil;
Tanguay, Jean-Francois; Tremblay,
Johanne
20022007
$0
Liu, Peter
University
of
Toronto
Developing
an integrated
Canadian
strategy to
address heart
failure - gene
environment
interaction
of host stress
response
repertoire.
Alberta: ter Keurs, Henk EDJ;
British Columbia: McManus, Bruce
M; Manitoba: Dhalla, Naranjan
S; Dixon, Ian M; Kirhsenbaum,
Lorrie A; Singal, Pawan K; Ontario:
Arnold, J Malcolm O; Backx,
Peter H; McKelvie, Robert S;
Nolan, Robert P; Ross, Heather J;
Rouleau, Jean-Lucien; Tsui, LapChee; Yeh, Wen-Chen; Québec:
Hamet, Pavel; White, Michel; USA:
Van Eyk, Jennifer E
20022007
$233,333
Paré, Peter
University
of British
Columbia
Inflammatory
gene haplotypes and their
susceptibility in
cardiac, vascular
and pulmonary
disease.
British Columbia: Carlson,
Christopher; Chan-Yeung, Moira;
Frohlich, Jiri J; Graham, Jinko;
Hegele, Richard; Hill, John S;
James, A Russell; McManus,
Bruce M; Munt, Bradley I; Nelson,
Colleen; Sandford, Andrew J;
Schellenberg, Robert; Scott, J
Tebutt; Thompson, Christopher
R; Walley, Keith R; Manitoba:
Anthonisen, Nicholas R; Becker,
Allan
20022007
$0
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
50
Total 06-07 $ Total $*
(All Partners) HSF FMC
(tous les
partenaires)
$396,771
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
$0
$2,632,272
I
$258,333 $2,000,000
$2,550,000
I, II, IV
$398,908
$2,744,489
I, II
$0
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Training Programs
Programmes de formation
Focus on Stroke 4 2005
Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D
Total Initiative Funding: $1,130,500
HSF Total Initiative Funding: $309,913
Opération AVC 4 2005
Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D
des IRSC
Financement total de l’initiative : 1 130 500 $
Financement total de l’initiative par la FMC : 309 913 $
Description: This initiative, led by HSF, supports doctoral research
awards, postdoctoral fellowships and new investigator awards
in the area of stroke. These funds help build greater capacity for
stroke research in Canada. This initiative has been launched by
HSF annually since 2002.
Description : Cette initiative menée par la FMC soutient des
bourses de recherche au doctorat, des bourses de recherche
postdoctorale et des bourses aux nouveaux chercheurs dans le
domaine des AVC. Ces fonds contribuent à améliorer la capacité
de recherche sur les AVC au Canada. Cette initiative est mise de
l’avant par la FMC annuellement depuis 2002.
Focus on Stroke 4 2005 Postdoctoral Fellowships
Opération AVC 4 2005 Bourses de recherche postdoctorale
Awardee
Institute
Récipiendaire Institut
Project
Supervisor
Projet
Directeur
Term 06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Cheung,
Paul, Kimming
St. Boniface
Establishing the causative
G.H. Research roles and mechanisms of
Centre
atherosclerosis induction by
Chlamydia pneumonia.
Pierce, Grant N
20052007
$11,892
$45,000
$23,784
$90,000
1
Kauffenstein,
Gilles GK
Université de
Laval
Rôle de la NTPDasel et des
ucleotides dans le contrôle
cardiaque et périphérique de
la pression artérielle.
Sevigny, Jean
20062008
16 183 $
45 000 $
25 514 $
90 000 $
I,II,IV
Ramlawi,
Basel
Beth Israel
Deaconess
Medical
Center
Microarray gene expression
profiles after cardiac surgery
and their correlation to
neurocognitive decline and
other clinical outcomes.
Sellke, Frank
20042006
$3,303
$12,500
$14,534
$55,000
I,II
Sun, HongShuo
Toronto
Western
Research
Institute
Stroke treatment using virally
mediated gene silencing of TRP
channels.
Tymianski,
Michael
20052007
$11,892
$45,000
$23,784
$90,000
I
Winship,
Ian R
University
of British
Columbia
Structural plasticity and
electrophysiology in cortical
neurons imaged during
recovery from stroke.
Murphy,
Timothy H
20052007
$11,892
$45,000
$23,784
$90,000
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
51
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 4 2005 Doctoral Research Awards
Opération AVC 4 2005 Bourses de recherche au doctorat
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Aleyasin,
Hossein
University of
Ottawa
The role of DJ-1, in stroke model
of neuronal death.
Park, David
S
20052008
$5,814
$22,000
$17,441
$66,000
I,II
Brown,
Stephen
Thomas
McMaster
University
The differential industion and
function of the HIF family of
transcription factors in response
to hypoxia.
Nurse,
Colin A
20052008
$5,814
$22,000
$17,441
$66,000
I
Buttigiege,
Josef A
McMaster
University
Mechanism of oxygen sensing
in adrenalmedullary chromaffin
cells.
Nurse,
Colin A
20052008
$5,814
$22,000
$17,441
$66,000
I
Clark, Darren
L
University of
Alberta
Clinical feasibility of mild
prolonged hypothermia –
a physiology study.
Colbourne,
Frederick
20052008
$5,814
$22,000
$17,441
$66,000 I,II,III,IV
Hundza,
Sandra
University of
Victoria
Effect of arm ycling training on
the neural control and function of
arm and leg muscles after stroke.
Zehr, E Paul
20052008
$5,814
$22,000
$17,441
$66,000
I,II
Langdon,
Kris D
Memorial
University of
Newfoundland
Effect of cognitive and physical
activity on the progression of
vascular dementia.
Corbett,
Dale R
20052008
$5,814
$22,000
$17,441
$66,000
I
Maxwell,
Kimberley A
University of
Calgary
Factors mediating neuronal
replacement following brain
injury.
Dyck,
Richard H
20052007
$5,814
$22,000
$11,628
$44,000
I,II
Rashidian,
Juliet
University of
Ottawa
The role of cyclin dependent
kinases in ischemia/excitotoxic
neuronal death.
Park, David
S
20052008
$5,814
$22,000
$17,441
$66,000
I,II
Theurer,
Julie A
University
of Western
Ontario
Oropharyngeal stimulation
as a treatment for swallowing
impairment following stroke.
Martin,
Ruth E
20042007
$5,814
$22,000
$14,893
$54,500
I,II
Windle,
Victoria
Memorial
University of
Newfoundland
Role of norepinephrine in
recovery of function after focal
ischemia in rats.
Corbett,
Dale R
20052006
$925
$3,500
$5,814
$22,000
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
52
Term
Durée
06-07 $
HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 3 2004
Partners: HSF, AstraZeneca, CSN, CIHR/Rx&D
Total Initiative Funding: $1,437,711
HSF Total Initiative Funding: $343,552
Opération AVC 3 2004
Partenaires : FMC, AstraZeneca, RCACV, programme Rx&D
des IRSC
Financement total de l’initiative : 1 437 711 $
Financement total de l’initiative par la FMC : 343 552 $
Focus on Stroke 3 2004 New Investigators
Opération AVC 3 2004 Bourses de nouveaux chercheurs
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Kong, Jiming
BNIP3-activated atypical
apoptosis pathway in ischemic
neuronal cell death.
N/A
20042009
$14,250
$57,000
$71,250
$285,000
I
Investigations of novel strategies
to improve cellular and behavioral outcomes after adult and
perinatal cerebral ischemia.
N/A
20042009
$14,250
$57,000
$71,250
$285,000
I
Term
Durée
06-07 $
HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
University of
Manitoba
Todd, Kathryn University of
G
Alberta
Term
Durée
06-07 $
HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Focus on Stroke 3 2004 Research Fellowships
Opération AVC 3 2004 Bourses de perfectionnement en recherche
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Claydon,
Thomas W
University
of British
Columbia
Molecular mechanism underlying
the ischemia and pH-sensitivity of
the neuronal and smooth muscle
voltage-gated K+channels, Kv1.4
and Kv1.5.
Fedida,
David
20042006
$792
$3,333
$20,750
$90,000
I
Naska, Sibel
Hospital for
Sick Children
Role of the p53 family in
excitotoxicity-induced neuronal
apoptosis.
Miller,
Freda D
20032007
$10,375
$45,000
$35,144
$151,923
I
Saposnik,
Gustavo
London Health
Sciences
Centre
Preserving cognition by
improving vascular risk factors
control: a randomized controlled
trial.
Hachinski,
Vladimir
20042007
$12,750
$55,000
$38,250
$165,000
II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
IV: Population Health
IV : Santé de la population
53
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 3 2004 Doctoral Research Awards
Opération AVC 3 2004 Bourses de recherche au doctorat
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Term
Durée
Choi, Hyun
Beom
University
of British
Columbia
The role(s) of P2X7 receptor in
cerebral ischemia.
McLarnon,
James G
20032006
$833
$3,500
$11,083
$47,500
I
Ford,
Matthew
Robarts
Research
Institute
Computational fluid dynamics
modeling of endovascular
aneurysm therapy.
Steinman,
David A
20042007
$4,292
$18,500
$14,541
$62,500
I
Gharbawie,
Omar A
University of
Lethbridge
Neural and behavioural correlates Whishaw,
of subcortical middle cerebral
Ian
artery ischemia.
20032006
$2,500
$10,500
$12,750
$54,500
I
MacIntosh,
Bradley
Sunnybrook
Combining functional imaging
Health Sciences and electromyography to assess
Centre
lower limb deficits in stroke
recovery.
20032006
$1,667
$7,000
$11,917
$51,000
II
Veljkovic,
Dragoslava
McMaster
University
20042008
$5,000
$21,000
$14,521
$62,417
I
Graham,
Simon J
Expression and biological
Hayward,
functions of fibrinolytic proteins in Catherine
cultured human megakaryocytes. P M
Focus on Stroke 2 2003
Partners: HSF, CSN, CIHR/Rx&D, AstraZeneca
Total Initiative Funding: $1,259,017
HSF Total Initiative Funding: $331,824
06-07 $
HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Opération AVC 2 2003
Partenaires : FMC, RCACV, programme Rx&D des IRSC,
AstraZeneca
Financement total de l’initiative : 1 259 017 $
Financement total de l’initiative par la FMC : 331 824 $
Focus on Stroke 2 2003 New Investigators
Opération AVC 2 2003 Bourses de nouveaux chercheurs
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Liu, Fang
Protein-protein interactions in
the regulation of AMPA receptor
mediated neurotoxicity.
N/A
Centre for
Addiction and
Mental Health
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
54
Term
Durée
20032008
06-07 $
HSF
FMC
$18,833
Total 06-07 $
(All Partners)
(tous les
partenaires)
$57,000
Total $*
HSF
FMC
$93,167
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
$281,000
I
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Focus on Stroke 1 2002
Partners: HSF, CSN, ICRH, CIHR/Rx&D, AstraZeneca
Total Initiative Funding: $1,714,855
HSF Total Initiative Funding: $324,855
Opération AVC 1 2002
Partenaires : FMC, RCACV, ISCR, programme Rx&D des IRSC,
AstraZeneca
Financement total de l’initiative : 1 714 855 $
Financement total de l’initiative par la FMC : 324 855 $
Focus on Stroke 1 2002 New Investigators
Opération AVC 1 2002 Bourses de nouveaux chercheurs
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Whelan,
Patrick
University of
Calgary
Sensory control of locomotion in
the developing mouse.
N/A
20022007
$11,400
$57,000
$57,000
$285,000
I
Wilson,
Richard
University of
Calgary
Chemoreceptor interactions and
neural plasticity in the control of
breathing.
N/A
20022007
$11,400
$57,000
$57,000
$285,000
I
Andres Petrasovits Scholarship 2004
Partners: ICRH, HSF
Total Initiative Funding: $213,508
HSF Total Initiative Funding: $106,754
La bourse de recherche Andres Petrasovits 2004
Partenaires : ISCR, FMC
Financement total de l’initiative : 213 508 $
Financement total de l’initiative par la FMC : 106 754 $
Description: This special award was developed in memory of
Dr. Andres Petrasovits, an eminent leader who devoted nearly
three decades of his life to cardiovascular health policy. This
partnership will support one fellowship award, valued at $70,000
per year for three years in the area of cardiovascular health
policy research as it relates to the prevention and control of
cardiovascular disease.
Description : Cette bourse spéciale a été instaurée en mémoire
de Dr Andres Petrasovits, éminent chef de file ayant consacré trois
décennies de sa vie aux politiques de santé cardiovasculaire. Ce
partenariat permet de soutenir une bourse de perfectionnement
en recherche évaluée à 70 000 dollars par année sur trois ans,
dans le domaine de la recherche sur les politiques de santé
cardiovasculaire et leur lien avec la prévention et le contrôle des
maladies cardiovasculaires.
Andres Petrasovits Scholarship 2004 Research Fellowships
La bourse de recherche Andres Petrasovits 2004 Bourses de perfectionnement en recherche
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Riley, Barbara
A political ecology of primary
prevention: the case of cardiovascular disease in Canada.
Edwards,
Nancy
Christine
University of
Ottawa
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Term
Durée
20042007
06-07 $
HSF
FMC
$35,000
III: Health Services/Systems
III : Services et systèmes de santé
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$70,000 $106,754
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
$213,508
IV
IV: Population Health
IV : Santé de la population
55
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Canadian Tobacco Control Research Initiative 2004
Partners: INMHA, ICR, IAPH, ICRH, IGH, IHDCYH, NCIC, CCS,
HSF, HC, CLA, L’Association Pulmonaire du Québec, CTCRI
Total Initiative Funding: $9,525,000
HSF Total Initiative Funding: $803,450
Initiative canadienne de recherche pour la lutte contre le tabagisme 2004
Partenaires : INSMT, IC, ISA, ISCR, ISFH, IDSEA, INCC, SCC, FMC,
SC, APC, APQ, ICRCT
Financement total de l’initiative : 9 525 000 $
Financement total de l’initiative par la FMC : 803 450 $
Description: This initiative is focused on developing research
capacity in the area of tobacco control and nicotine addiction;
addressing gaps in research data; stimulating knowledge
translation; fostering national coordination and building
international collaboration. Outcomes of this research should
inform intervention strategies. Three ICE Grants, two Policy
Research Grants, and one Knowledge Synthesis Grant were
funded. Only the projects which received funding from HSF
are listed below.
Description : Cette initiative a pour but de développer la capacité
de recherche dans le domaine de la lutte contre le tabagisme et
la dépendance à la nicotine; d’aborder les écarts dans les
données de la recherche; de favoriser la coordination nationale
et de bâtir la collaboration internationale. Les résultats de cette
recherche devraient donner corps aux stratégies d’intervention.
Trois subventions EIRC, deux subventions de recherche sur les
politiques et une subvention de synthèse des connaissances ont
été financées. Seuls les projets ayant reçu un financement de la
FMC sont mentionnés dans la liste qui suit.
Canadian Tobacco Control Research Initiative 2004 Interdisciplinary Capacity Enhancement (ICE) Grant
Initiative canadienne de recherche pour la lutte contre le tabagisme 2004 Subventions aux équipes interdisciplinaires de renforcement
des capacités (EIRC)
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
O’Loughlin,
Jennifer
Strengthening the links
between research,
Ontario: Tyndale, Rachel;
Québec: Gauvin, Lise;
Paradis, Gilles; Renaud,
Lise; Tremblay, Michele;
USA: DiFranza, Joseph
McGill
University
practice, and public
policy to reduce the
burden of tobacco.
Term 06-07 $
Durée HSF
FMC
20042009
$135,000
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$300,000 $675,000
Total $* (All
Partners)
(tous les
partenaires)
$1,500,000
Theme
Thème
III
Target Obesity Personnel Awards 2004
Partners: CDA, ICR, IGH, IHDCYH, IMHA, INMD, HSF
Total Initiative Funding: $1,400,000
HSF Total Initiative Funding: $339,149
Bourses Objectif Obésité 2004
Partenaires : ACD, IC, ISFH, IDSEA, IALA, INMD, FMC
Financement total de l’initiative : 1 400 000 $
Financement total de l’initiative par la FMC : 339 149 $
Description: The aim of this initiative is to encourage more
students, recent graduates and postgraduates, including health
professionals (such as physicians, nurses, dietitians, exercise
physiologists, and behavioral scientists) to train in the area of
obesity research and to support newly established investigators
to conduct research in the field of obesity. There is an emphasis
on the risks for chronic diseases and strategies to reduce these
risks. HSF was the lead organization in this initiative.
Description : L’objectif de cette initiative consiste à encourager
davantage d’étudiants, de diplômés de premier cycle et d’études
supérieures, comme des professionnels de la santé, des médecins,
des infirmières, des diététistes, des physiologistes de l’exercice
et des chercheurs du comportement à recevoir une formation
dans le domaine de la recherche sur l’obésité et de soutenir des
chercheurs nouvellement établis à mener des recherches dans le
domaine de l’obésité. L’accent est mis sur les risques de maladies
chroniques et sur les stratégies destinées à réduire ces risques. La
FMC a été l’organisation qui a dirigé cette initiatve.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
56
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Target Obesity Personnel Awards 2004 New Investigators
Bourses Objectif Obésité 2004 Bourses de nouveaux chercheurs
Awardee
Project
Supervisor
Récipiendaire Institut
Institute
Projet
Directeur
Netticadan,
Thomas
Mechanisms underlying cardiac
contractile dysfunction in type II
diabetes.
N/A
St. Boniface
G.H. Research
Centre
Term
06-07 $
Durée HSF
FMC
20042009
$48,708
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
$55,000 $256,124
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
$275,000
I
Target Obesity Personnel Awards 2004 Research Fellowships
Bourses Objectif Obésité 2004 Bourses de perfectionnement en recherche
Awardee
Institute
Project
Supervisor Term
Directeur Durée
06-07 $ Total 06-07 $ Total $*
HSF
(All Partners) HSF
FMC
(tous les
FMC
partenaires)
Total $* (All Theme
Partners)
Thème
(tous les
partenaires)
Récipiendaire Institut
Projet
Fry, W Mark
Queen’s University
Electrophysiological characterisation of orexinergic neurons in the
lateral hypothalamus.
Ferguson,
Alastair
20042007
$0
$45,000
$0
$135,000
I
Steinberg,
Gregory R
St. Vincent’s
Institute of Medical
Research
Intracellular mechanisms
contributing to skeletal muscle
leptin resistance in obesity.
Kemp,
Bruce E
20042007
$0
$45,000
$0
$150,000
I
Tannenbaum, Montreal
Beth M
Neurological
Institute
Alterations of brain circuitry in
obesity: The role of reward and
motivational state.
Dagher,
Alain
20052008
$0
$45,000
$0
$135,000
II
Yoshioka,
Mayumi
Identification and cloning of
appetite and satiety controlling
genes.
St-Amand,
Jonny
20042007
$0
$45,000
$0
$150,000
I
Centre hospitalier
de l’Université Laval
Target Obesity Personnel Awards 2004 Doctoral Research Awards
Bourses Objectif Obésité 2004 Bourses de recherche au doctorat
Awardee
Institute
Project
Supervisor
Récipiendaire Institut
Projet
Directeur
Term
Durée
Anderson,
Kristal D
University of
Saskatchewan
Target Obesity: Identifying childhood
predictors of adulthood obesity.
Chad,
Karen E
20042007
$0
$22,000
$0
$66,000
I
Jia, Xuming
University of
Saskatchewan
Methylglyoxal induced insulin
resistance.
Wu,
Lingyun
20042007
$0
$22,000
$0
$66,000
I
Major,
Geneviève
GM
Université de
Laval
Le syndrome d’apnées obstructives
du sommeil et les variations de la
dépense énergétique.
Tremblay,
Angelo
20042007
10 250 $
22 000 $ 30 750 $
66 000 $
II
Purdham,
Daniel
University
of Western
Ontario
The role of the cardiac leptin system
in myocardial ischemia and
reperfusion.
Karmazyn,
Morris
20042007
$0
$22,000
$0
$66,000
I
Tomlinson,
Juliana J
Ottawa Health The identification of transroptional
Research
intermediary factor 1 beta in the
Institute
regulation of steroid induced
adipoctye differentiation.
Haché,
Robert JG
20032006
$10,500
$10,500 $10,500
$54,500
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
06-07 $ Total 06-07 $
HSF
(All Partners)
FMC
(tous les
partenaires)
III: Health Services/Systems
III : Services et systèmes de santé
Total $* Total $* (All
HSF
Partners)
FMC
(tous les
partenaires)
Theme
Thème
IV: Population Health
IV : Santé de la population
57
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Strategic Training Initiative in Health Research (STIHR) 2003
Partners: HSF, ICRH
Total Initiative Funding: $12,471,000
HSF Total Initiative Funding: $1,248,788
Initiatives stratégiques de formation en recherche dans le
domaine de la santé (ISFRS) 2003
Partenaires : FMC, ISCR
Financement total de l’initiative : 12 471 000 $
Financement total de l’initiative par la FMC : 1 248 788 $
Description: The aim of the STIR Initiative is to encourage
transdisciplinary, integrative heath research, in part through the
training of the next generation of researchers, and to increase
the capacity of Canada’s health research enterprise to address
important research questions in all areas of health research.
HSF supported a total of 11 STIRs over two competitions
(2003 and 2002).
Description : L’objectif de l’Initiative stratégique pour la formation
en recherche dans le domaine de la santé (ISFRS) est de favoriser
la recherche en santé transdisciplinaire intégrative, en partie
par la formation de la prochaine génération de chercheurs, et
d’accroître la capacité de l’entreprise de recherche en santé au
Canada à répondre aux questions importantes touchant tous les
domaines de la recherche en santé. La FMC a appuyé 11 ISFRS
au total au cours de deux concours (2003 et 2002).
Strategic Training Initiative in Health Research (STIHR) 2003
Initiatives stratégiques pour la formation en recherche dans le domaine de la santé (ISFRS) 2003
Principal
Institute
Project
Co-Investigator(s)
Investigator
Institut
Projet
Co-chercheur(s)
Arthur,
Heather M
McMaster
University
Training
program for
the development of
cardiovascular nursing
research
capacity in
Canada.
Alberta: King, Kathryn M; Tapp, Dianne
M; British Columbia: Young, Lynne E;
Nova Scotia: McFetridge, Judith Ann;
Ontario: Rukholm, Ellen; Tranmer, Joan
E; Watt-Watson, Judith H; Québec:
Purden, Margaret Ann; RobichaudEkstrand, Sylvie
20032009
$37,198
$299,963 $203,143
$1,800,000
III, II,
IV
Fliegel, Larry
University
of Alberta
Membrane
proteins and
cardiovascular disease.
Alberta: Casey, Joseph R; Coe, James
Y; Glover, JN Mark; James, Michael NG;
Kavanagh, Katherine M; Light, Peter E;
Michalak, Marek; Robertson, Murray;
Young, Howard S
20032009
$37,198
$278,463 $213,143
$1,671,000
I
MacGillivray,
Ross T
University
of British
Columbia
Training
program in
transfusion
science.
British Columbia: Brooks, Donald E;
Burtnick, Leslie D; Carter, Cedric J;
Devine, Dana V; Haynes, Charles A;
Karsan, Aly; Lehman, Darrin L; Mauk,
Grant; Maurer-Spurej, Elizabeth;
McMaster, Robert; McNagny, Kelly
M; Orvig, Chris; Overall, Christopher;
Podor, Thomas J; Pryzdial, Edward LG;
Roberts, Clive R; Scott, Mark; Strynadka,
Natalie C J
20032009
$37,198
$299,963 $193,143
$1,800,000
II
Chercheur
Term
06-07 $
Durée HSF
FMC
principal
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
>>
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
58
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal
Institute
Project
Co-Investigator(s)
Investigator
Institut
Projet
Co-chercheur(s)
Term
06-07 $
Durée HSF
FMC
Paré, Peter D University
of British
Columbia
IMPACT:
integrated
and
mentored
pulmonary
and cardiovascular
training.
British Columbia: Allard, Michael F;Ayas,
Najib; Bai, Tony;Cunningham, Kenneth
F; Dorscheid, Delbert R; Fleetham,
John A; Frohlich, Jiri J; Fitzgerald, J
Mark; Granville, David J; Hayashi, Shizu;
Hegele, Richard; Hill, John S; Hogg,
James C; Levy, Robert Daniel; Mayo,
John; McManus, Bruce M; Muller,
Nestor; O, Karmin; Podor, Thomas J;
Pritchard, Haydn; Road, Jeremy D;
Russell, James A; Ryan, Frank; Sandford,
Andrew J; Schellenberg, Robert;
Seow, Chun Y; Van Breemen, Casey;
van Eeden, Stephan F; Walley, Keith
R; Wang, Xiaodong; Yang, Decheng;
Manitoba: Anderson, Hope D Intengan;
Becker, Allan; Choy, Patrick C; Dhalla,
Naranjan S; Dixon, Ian M; Ducas, John;
Gounni, Abdelilah Soussi; Guzman,
Randolph P; Halayko, Andrew; Hatch,
Grant M; Kardami, Elissavet; Lukas,
Anton; Mink, Steven N; Netticadan,
Thomas; Pierce, Grant N; Singal,
Pawan K; Stephens, Newman L; Tappia,
Paramjit S; Wigle, Jeffrey T; Yang, Xi;
Zahradka, Peter
20032009
$37,198
$299,963 $213,143
$1,800,000
I, II
Vance,
Dennis E
University
of Alberta
The
SCOLAR
(stroke, cardiovascular,
obesity,
lipid, atherosclerosis
research)
training
program.
Alberta: Agellon, Luis B; Francis,
Gordon A; Lee, Mark W; Lehner,
Richard; Majumdar, Sumit; Vance, Jean
20032009
$37,198
$299,963 $213,143
$1,800,000
I,II
Wang, Rui
Lakehead
University
Gasotransmitter
research
and training
(GREAT).
Alberta: Roth, Sheldon; Ontario: Brien,
James F; Nakatsu, Kanji; Québec:
Blaise, Gilbert A; Troncy, Eric T E;
Saskatchewan: Gopalakrishnan, Venkat;
Hurst, Thomas S; Loewen, Michele;
McNeill, J Robert; Melo, Luis Gabriel;
Reeder, Bruce; Saucier, Deborah;
Thornhill, James A; Van uum, Stan H M;
Wilson, Thomas W; Wu, Lingyun; Zhang,
Wenjun
20032009
$37,198
$299,963 $213,143
$1,800,000
I
Chercheur
principal
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
Total 06-07 $ Total $*
(All Partners) HSF
(tous les
FMC
partenaires)
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
IV: Population Health
IV : Santé de la population
59
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Strategic Training Initiative in Health Research (STIHR) 2002
Partners: HSF, ICRH, AHFMR, IGH, CCMB, ICR, IG, IHSPR, III,
INMD, INMHA, IPPH, CIHR-KT, MSFHR
Total Initiative Funding: $9,394,360
HSF Total Initiative Funding: $850,000
Initiatives stratégiques de formation en recherche dans le
domaine de la santé (ISFRS) 2002
Partenaires : FMC, ISCR, AHFMR, ISFH, CCMB, IC, IG, ISPS, IMII,
INMD, INSMT, ISPP, IRSC-AC, MSFHR
Financement total de l’initiative : 9 394 360 $
Financement total de l’initiative par la FMC : 850 000 $
Strategic Training Initiative in Health Research (STIHR) 2002
Initiatives stratégiques pour la formation en recherche dans le domaine de la santé (ISFRS) 2002
Principal
Institute
Investigator Institut
Project
Co-Investigator(s)
Projet
Co-chercheur(s)
Term
Durée
Chercheur
06-07 $
HSF
FMC
principal
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $*
HSF
FMC
Total $* (All
Partners)
(tous les
partenaires)
Theme
Thème
Armstrong,
Paul
University
of Alberta
Tomorrow’s
Research
Cardiovascular
Health
Professionals
(TORCH).
Alberta: Allen, Peter S; Anderson,
Todd J; Archer, Stephen L; Duff,
Henry J; Ghali, William; Giles,
Wayne R; Haykowsky, Mark J;
Jensen, Louise A; Knudtson, Merril
L; Lopaschuk, Gary D; Loutzenhiser,
Rodger D; McAlister, Finlay A;
Michelakis, Evangelos; Plotnikoff,
Ronald C; Raine, Kim; Rebeyka,
Ivan M; Schulz, Richard; Sheldon,
Robert S; Shuaib, Ashfaq; ter Keurs,
Henk EDJ; Tsuyuki, Ross T; Ontario:
Hayward, Robert SA; Menon, Ravi S
20012007
$50,000
$268,455
$300,000
$1,559,640
I, II, III,
IV
Cameron,
Roy
University
of
Waterloo
Tobacco
Research.
British Columbia: Best, Allan;
Johnson, Joy; Lovato, Chris; Ratner,
Pamela A; Ontario: Ashley, Mary
Jane; Brown, K Stephen; Campbell,
Sharon; Cohen, Joanna; Cook,
Richard; Ferrence, Roberta; Fong,
Geoffrey; Manske, Stephen R;
McDonald, Paul W; Poland, Blake;
Selby, Peter; Single, Eric; Skinner,
Harvey; Sparks, Robert; Thompson,
Mary E; Tyndale, Rachel; Zanna,
Mark P
20022007
$0
$273,601
$0
$1,499,870
IV
Chung,
Stephen
University
of British
Columbia
Health research
training
program in
transplantation.
British Columbia: Duronio, Vincent;
Johnson, Pauline; Landolt, Monica;
Levy, Robert Daniel; McMaster,
Robert; Qayumi, A Karim; The,
Hung-Sia; Warnock, Garth; Yoshida,
Eric M
20022007
$0
$275,000
$0
$1,500,000
II
Fenster,
Aaron
The John
P. Robarts
Research
Institute
Vascular and
cerebrovascular
transdisciplinary training program
(vcTPP).
Ontario: Donner, Allan; Ellis,
Christopher G; Ferguson, Stephen
S G; Hegele, Robert A; Huff, Murray
W; Kamel, Mohamed; Pickering,
J Geoffrey; Rutt, Brian K; Salama,
Magdy
20022007
$45,833
$242,917
$250,000
$1,325,000
I
>>
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
60
Heart and Stroke Foundation | Research Report 2006-2007
Principal
Institute
Investigator Institut
Project
Co-Investigator(s)
Projet
Co-chercheur(s)
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Term
Durée
Chercheur
06-07 $
HSF
FMC
principal
Liu, Peter
University Cardiovascular
of Toronto research:
molecules to
populations,
heart failure to
prevention.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
Manitoba: Dixon, Ian M;
Kirshenbaum, Lorrie A; Naranjan, S
Dhalla; Ontario: Alter, David; Arnold,
J Malcolm O; Backx, Peter H;
Benoit, Bruneau; Bradley, T Douglas;
Floras, John S; Langille, B Lowell;
Nolan, Robert P; Parker, Thomas;
Ross, Heather J; Rouleau, JeanLucien; Sole, Michael J; Stewart, A
Keith; Stewart, Duncan J; Tsui,
Lap-Chee; Tu, Jack V; Van Eyk,
Jennifer E; Weisel, Richard D;
Wittnich, Carin; Yeh, Wen-Chen;
Yusuf, Salim; Québec: Hamet, Pavel
II: Clinical
II : Clinique
20032008
Total 06-07 $
(All Partners)
(tous les
partenaires)
$50,000
III: Health Services/Systems
III : Services et systèmes de santé
$285,000
Total $*
HSF
FMC
$300,000
Total $* (All
Partners)
(tous les
partenaires)
$1,710,000
Theme
Thème
I, II, III,
IV
IV: Population Health
IV : Santé de la population
61
APPENDIX
Annexe
B
NATIONAL PERSONNEL AWARDS BY PROGRAM
BOURSES DE FONCTIONNEMENT NATIONALES PAR PROGRAMME
Dr. John Seubert and Dr. Ken Butcher (University of Alberta) were the 2007/2008 recipients of the Heart and Stroke Foundation McDonald Scholarship
Award and Henry J.M. Barnett Scholarship Award, respectively.
Dr John Seubert et Dr Ken Butcher (Université de l’Alberta) étaient respectivement lauréats 2007-2008 de la Bourse McDonald et de la
Bourse Henry J. M. Barnett de la Fondation des maladies du cœur.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Doctoral Research Awards | Bourses de recherche au doctorat
Awardee
Supervisor
Institute
Project
Keywords
Term
06-07 $
Total $*
Theme
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Antunes,
Tayze Tatiana
Sorisky,
Alexander
University of
Ottawa
Thyroid stimulating hormone
as a regulator of atherogenic
adipokines.
Thyroid stimulating hormone,
adipose tissue, interleukin-6,
adipokines, cardiovascular
disease.
20062009
$21,000
$63,000
I, II
Ayach, Bilal
Liu, Peter P
Toronto
General
Hospital
Cytokine signalling pathways
regulating bone marrow
derived stem-cell therapy
post-MI.
Myocardial infarction, cytokines,
stem cell therapy.
20052007
$21,000
$42,000
I
Beyea,
Michael M
Huff,
Murray W
Robarts
Research
Institute
Attenuation of foam cell
formation via selective
activation of gene expression.
Atherosclerosis, lipid laden
foam cells, cholesterol and lipid
homeostasis.
20062008
$17,500
$21,000
I
Boucher,
Jonathan G
Sparks,
Daniel L
University of HDL regulates triacylglyceride
Ottawa Heart metabolism.
Institute
Hepatic lipase, lipoprotein
lipase, atherosclerosis, heart
disease, tracylglycerides.
20042007
$10,500
$41,500
I
Bourgault,
Steve
Fournier,
Alain
Institut
national de
la recherche
scientifique
Accidents vasculaires
cérébraux, apoptose, neurone,
neuropeptide, neuroprotection.
20062009
21 000 $
63 000 $
I
Caron,
Annabelle
Guillemette, Université de
Gaétan
Sherbrooke
Mécanismes de régulation du
Second messagers, récepteurs,
récepteur de type 3 de l’inositol signallisation intracellulaire,
1,4,5 trisphosphate (IP3R3).
phosphorylation, inositol 1,4,5
trisphosphate recepteur (IP3Rs).
20052008
21 000 $
63 000 $
I
Cayouette,
Sylvie
Boulay,
Guylain
Identification des protéines
impliquées dans le routage
intracellulaire de TRPC6.
Signalisation intracellulaire,
routage intracellulaire, canaux
calciques, Rab, TRPC6.
20062009
17 500 $
42 000 $
I
Chan, Anita
YM
Dyck, Jason University of
RB
Alberta
The effects of PRKAG2
mutations on cardiac energy
metabolism.
AMPK, PRKAG2, hypertrophy,
metabolism, glycogen.
20062009
$21,000
$63,000
I
Cho, Taesup
Wang, Yu
Tian
University
of British
Columbia
Functional characterization of
synaptic plasticity and synapse
formation in the neural stem
cells during stroke.
Stem cell, PSD-95, neuroligin,
synaptic plasticity, stroke.
20052008
$21,000
$63,000
I
Clément,
Martin
Escher,
Emmanuel
Université de
Sherbrooke
Détermination de la pochette
de liaison du récepteur AT1
par MPA (methionine proximity
assay).
Recepteurs couples aux
proteines G, angiotensine II,
pochette de liaison, structure
mecanismes d’activation.
20062009
21 000 $
63 000 $
I
Cruz, Rani P
McManus,
Bruce M
St. Paul’s
Hospital
Elucidating the role of cytochrome p450 enzymes in mitral
valve disease.
Mitral valve disease,
cytochrome p450,
myofibroblasts, apoptosis.
20042007
$21,000
$62,000
I
Dastani, Zari
Genest, Jr,
Jacques
McGill
University
Genetics of high density
lipoprotein-cholesterol.
Genetics, gene identification,
cholesterol, high density
lipoprotein, cardiovascular
risk factor.
20062009
$21,000
$63,000
I, II, IV
Université de
Sherbrooke
Développement et
caractérisation
pharmacologique d’agonistes à
haute stabilité métabolique du
neuropeptide PACAP.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
64
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
David,
Laurence S
Snutch,
Terrance P
University
of British
Columbia
Cardiac 1H T-type calcium
channels and hypertension.
Hypertension, T-type clacium
channel, smooth muscle
contraction, ion channel
modulation, site-directed
mutagenesis.
20062008
$21,000
$42,000
I
Dent, Melissa
R
Dhalla,
Naranjan S
University of
Manitoba
Gender differences in the
mechanisms involved in the
development of cardiac
remodelling.
20062010
$21,000
$63,000
I
Duan,
Qingling
Rouleau,
Guy A
Centre hospitalier de
l’Université
de Montréal
Genetic investigation of
angioedema associated with
angiotensin I-converting
enzyme inhibitors.
20062009
$17,500
$42,000
I, II, IV
Dungey,
Alison A
Stewart,
Duncan J
St. Michael’s
Hospital
Kruppel-like factor 2: a novel
treatment strategy for pulmonary arterial hypertension?
20062009
$21,000
$63,000
I, II
Duval,
Martine
Gratton,
JeanPhilippe
Institut de
recherches
cliniques de
Montréal
Mouvements cellulaires du
récepteur VEGFR-2 du VEGF
dans les cellules endothéliales.
VEGF, récepteur, oxyde
nitrique (NO), signalisation
intracellulaire, cellules.
20042007
21 000 $
62 000 $
I
Fang,
Xiangping
Sweeney,
Gary
York
University
Regulation of glucose and fatty
acid metabolism in cardiomyocytes by adiponectin.
Adiponectin, obesity, heart
failure, carbohydrate and lipid
metabolism.
20062008
$21,000
$42,000
I
Flynn, Robyn
Zamponi,
Gerald W
University of
Calgary
Neurexin and neuroligin
modulate neuronal reorganization through interactions with
specific receptors.
Neuroligin, neurexin, neuronal
reorganization, calcium
channels, NMDA receptor.
20052008
$21,000
$63,000
I
Foster, Glen E
Poulin,
Marc J
University of
Calgary
Cerebral blood flow regulation
in obstructive sleep apnea.
Sleep disordered breathing,
chronic intermittent hypoxia,
cerebrovascular reactivity testing, endothelial function, stroke.
20062009
$21,000
$63,000
I, II, IV
Gao, Guang
Luo,
Honglin
St. Paul’s
Hospital
Role of the ubiquitin/
proteasome pathway in
coxsackievirus-induced
myocarditis.
Coxsackievirus, myocarditis,
ubiquitin/proteasome
pathway, virus pathogenesis,
cardiomyocytes.
20052008
$21,000
$63,000
I
Gaskari,
Seyed A
Lee,
Samuel S
University of
Calgary
Role of endocannabinoid
system in the genesis of
cirrhotic cardiomypathy.
Cardiomypathy, cirrhosis,
endocannabinoids, signal
transduction.
20042008
$21,000
$62,500
I
Ghosh, Sanjoy Rodrigues,
Brian B
University
of British
Columbia
Cardiac lipotoxicity of n-6 PUFA
in acute diabetes.
PUFA, cell death, heart,
diabetes, glutathione.
20052007
$3,500
$24,500
I
Gordon,
Grant RJ
University of
Calgary
Global enhancement of
glutamate synapses by glial
cell networks.
Magnocellular neuroendocrine
cells (MNCs), vasopressin,
hypothalamus, noradrenaline,
glial cells.
20062007
$10,500
$10,500
I
Bains,
Jaideep
Singh
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Pharmacogenomics,
angiotensin I-converting
enzyme inhibitors, quantitative
trait, susceptibility loci, kinin
metabolism.
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
65
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Graham, Drew Rush,
Aaron
James WE
University of
Waterloo
Mechanisms in vascular nitric
oxide bio-availability in chronic
hypertension and exercise
training.
Hypertension, exercise,
endothelial function, nitric
oxide, oxidative stress.
20052009
$21,000
$63,000
I
Harder,
Christopher
John
McPherson,
Ruth
University of The role of hepatic SR-BI
Ottawa Heart trafficking in reverse cholesterol
Institute
transport.
SR-BI, HDL, heart disease,
reverse cholesterol transport,
intracellular trafficking.
20062007
$21,000
$21,000
I
Hogue, JeanCharles
Couture,
Patrick
Université
Laval
Effets de l’atorvastatine ou du
Lipoprotéines, athérosclérose,
fénofibrate chez les diabétiques diabète, statine, fibrate.
hypertriglycéridémiques.
20052008
21 000 $
63 000 $
I, II, IV
Hunter, Arwen Granville,
L
David J
St. Paul’s
Hospital
Cytochrome p450 2C enzymes
in peri-transplant ischemic
injury and transplant vascular
disease.
Ischemia, cytochrome p450,
allograft, arteriosclerosis,
endothelium.
20062009
$21,000
$63,000
I
Iyirhiaro,
Grace O
Park, David
S
University of Role of Pin1 in reactivation of
Ottawa Heart cell cycle proteins following
Institute
stroke injury.
Stroke, apoptosis, cell cycle,
cdks.
20062009
$21,000
$63,000
I
Jeyaraman,
Madhumathy
Kardami,
Elissavet
University of
Manitoba
Role of connexin43 in
protein kinase C mediated
cardioprotection.
Connexin43, protein kinaseC,
ischemia and CX43, PKC and
cardioprotection.
20052009
$19,250
$63,000
I
Jimenez,
Sarah
Cattini,
Peter A
University of
Manitoba
Genetic regulation of cardioprotective fibroblast growth
factors in the adult heart.
Genetic regulation,
cardioprotective FGF,
transgenic.
20032007
$3,500
$61,167
I
Khairallah,
Maya
Des
Rosiers,
Christine
Institut de
cardiologie
de Montréal
Metabolic interventions
targeting the dystrophic
heart: the potential benefits
of medium chain fatty acids.
Cardiomyopathy, Duchenne
muscular dystrophy, metabolic
disorders, 13C mass isotopomer
analysis, cardioprotective
therapies.
20042007
$7,000
$41,333
I
Kimmerly,
Derek S
Shoemaker,
J Kevin
University
of Western
Ontario
Exercise and central autonomic
control of cardiovascular
function in human health and
disease.
Humans, hypertension, central
autonomic centres, efferent
sympathetic nerve activity,
vascular control.
20042007
$10,500
$48,167
I
Kisilevsky,
Alexandra E
Zamponi,
Gerald W
University of
Calgary
Dopamine receptor coupling to
cav2.2 calcium channels.
Cav2.2 channels, G-proteins,
dopamine receptors, cerebral
ischemia.
20052007
$21,000
$42,000
I
Toronto
General
Hospital
c-Myb dependent vascular
smooth muscle cell
differentiation.
Embryonic stem cells, differentiation, vascular smooth muscle
cells, c-myb, targeted tissuespecific transgene knock-in.
20032007
$10,500
$61,500
I
Kolodziejska, Husain,
Karolina Maria Mansoor
06-07 $
Total $*
Theme
Thème
Lamont, Ryan
E
Childs,
Sarah J
University of
Calgary
PlexinD1 signalling in the
developing zebrafish.
Angiogenesis, vascular
patterning, VEGF signalling.
20052009
$21,000
$63,000
I
Laplante,
Marc-André
de
Champlain,
Jacques
Université de
Montréal
Rôle de la voie ERK-MAPK
dans l’hypertension induite par
l’angiotensine.
Hypertension, stress oxydatif,
vaisseaux, p42/44 ERK-MAPK,
angiotensine II.
20032007
179 $
59 512 $
I
Laroche,
Genevieve
Parent,
Jean-Luc
Université de
Sherbrooke
Role de l’interaction arrestinesGEFs de Arfl dans la fonction
du récepteur TP.
Recepteurs couples aux
proteines G, thromboxane A2,
petites proteines G, exocytose,
arrestines.
20062008
21 000 $
25 039 $
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
66
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Leclerc,
Patrice
Guillemette, Université de
Gaetan
Sherbrooke
Modulation de l’activité de
liaison du récepteur AT1 par
l’oxide nitrique.
Récepteur AT1, oxide nitrique,
S-nitrosylation, affinité de
ligand, alkylation.
20032007
3 500 $
61 167 $
I
Leung,
General
Moody,
Alan
Sunnybrook
Health
Sciences
Centre
Magnetic resonance imaging
of vulnerable plaque in the
coronary artery tree.
Magnetic resonance, heart
attack, vulnerable plaque.
20062009
$21,000
$63,000
I, II
Liang, Wenbin Ward,
Michael E
St. Michael’s
Hospital
The role of chloride channels
in hypoxia induced pulmonary
hypertension.
Hypoxia, human pulmonary
atrery smooth muscle, chloride
channels.
20062009
$21,000
$63,000
I
Liu, Zhen
Yang,
Decheng
St. Paul’s
Hospital
IGTP-induced PI3K/Akt signaling Interferon-y-inducible
pathway in coxackievirus B3GTPase, PI3K/Akt pathway,
caused myocarditis and dilated caxsackievirus B3, myocarditis.
cardiomyopathy.
20062009
$21,000
$63,000
I
Ljubicic,
Vladimir
Hood,
David A
York
University
Effect of physical activity on the
apoptotic susceptibility of the
aged heart.
20052009
$21,000
$63,000
I, II
Lussier, Marc
Boulay,
Guylain
Université de
Sherbrooke
Implication de RNF24 dans la
Biologie cellulaire, signalisation
régulation des canaux calciques cellulaire, calcium intracellulaire,
TRPCs.
TRPC, canal.
20062009
21 000 $
63 000 $
I
Martin,
Stéphane
Guillemette, Université de
Gaétan
Sherbrooke
Étude de la structure du
récepteur AT1 et des changements conformationnels causant
l’activation des GPCRs.
Récepteurs couplés aux
protéines G, angiotensine II,
structure, enclave de liaison,
mécanismes d’activation.
20052007
10 500 $
3 500 $
I
Nagareddy,
Prabhakara
Reddy
McNeill,
John H
University
of British
Columbia
Mechanisms of vascular
dysfunction in diabetes, role
of nitrosative stress.
Diabetes, nitric oxide, cardiovascular dysfunction, blood
pressure, nitrosative stress.
20062009
$21,000
$63,000
I
Neuspiel,
Margaret
McBride,
Heidi M
University of Mechanism and function of
Ottawa Heart mitochondrial derived vesicles.
Institute
Mitochondria, budding, MARi-1,
fission, dynamin1.
20062009
$17,500
$42,000
I
Pande, Jyoti
Grover,
Ashok K
McMaster
University
Caloxins: Search for high affinity Calcium homeostasis, cell
inhibitors.
signaling, plasma membrane
calcium pumps, drug discovery,
mutagenesis.
20052009
$17,500
$63,000
I
Papageorgiou, Floras,
Peter
John S
Christopher
Mount Sinai
Hospital
Participation of activated
coagulation factor XII (FXIIa) in
blood pressure regulation in
chronic renal failure.
Hypertension, chronic renal
failure, coagulation factor XII,
kallikrein-kinin system, nocturnal
hemodialysis.
20062008
$21,000
$42,000
I, II
Pop, Mihaela
Wright,
Graham
Sunnybrook
Health
Sciences
Centre
Magnetic resonance guidance
of radiofrequency ablation of
cardiac arrhythmias.
Cardiac arrhythmias,
magnetic resonance imaging,
radiofrequency ablation.
20042007
$21,000
$62,000
I
Proulx,
Christophe
Leduc,
Richard
Université de
Sherbrooke
Étude de la structure/fonction
du récepteur à l’urotensine II,
UT.
Récepteur UT, urotensine II,
internalisation, désensibilisation,
phosphorylation.
20052008
21 000 $
63 000 $
I
Pyke, Kyra E
Tschakovsky, Queen’s
Michael E
University
Stimulus response specificity of
human endothelial function.
Shear stress, nitric oxide,
vasodilation, brachial artery.
20062008
$17,500
$21,000
I, II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Mitochondria, aging, cardiac
muscle, apoptosis.
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
67
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Rezazadeh,
Saman
Fedida,
David
University
of British
Columbia
Real-time voltage clamp
fluorimetry to understand slow
and fast gating modes of the
Kvl.2 channel.
Cardiovascular, action potential,
ion channels, drug binding,
fluorimetry.
20062008
$21,000
$24,500
I
Ronald, John
A
Rutt, Brian
K
Robarts
Research
Institute
Magnetic resonance
imaging of a rabbit model
of atherosclerosis.
Atherosclerosis, cholesterol,
rabbit, magnetic resonance
imaging, contrast agents.
20052009
$21,000
$63,000
I
Rose, Patricia
Anne
Hudson,
Chris
Toronto
Western
Hospital
Age-related changes in
retinal vascular autoregulation
in normal and atherosclerotic
patients.
Autoregulation, atherosclerosis,
flowmetry, retina, statins.
20032007
$3,500
$61,167
II
Ruffell, Brian
H
Johnson,
Pauline
University
of British
Columbia
Monocyte recruitment to
inflammatory sites.
Inflammation, monocytes,
macrophages, hyaluronan,
CD44.
20062007
$21,000
$21,000
I
Saini, Harjot K
Dhalla,
Naranjan S
St. Boniface
G.H.
Research
Centre
Role of angiotensin II in
subcellular remodelling in
adult cardiomyocytes.
Adult cardiomyocytes, cardiac
gene expression, sarcoplasmic
reticular proteins, myofybrillar
proteins, angiotensin II
receptors.
20042007
$21,000
$62,000
I
Sauvageau,
Stéphanie
Thorin, Eric
Institut de
cardiologie
de Montréal
Functional characterization
of the dimerization and
intracellular trafficking of
endothelin receptors.
Endothelin receptors,
heterodimerization, intracellular
trafficking, endothelin
antagonists, pulmonary
hypertension.
20062009
$21,000
$63,000
I
Shamloul,
Rany
Wang, Rui
University of Role of heme oxygenase/
Saskatchewan carbon monoxide systems in
hypertension development.
20062007
$10,500
$10,500
I
Sharif, Reza N
Bourque,
Charles W
Montreal
General
Hospital
Molecular mechanisms of
osmoreception in the
hypothalamus.
Osmoreception, vasopressin,
supraoptic, neuroendocrine,
hypothalamus.
20052007
$15,999
$33,499
I
Singh, Raja B
Dhalla,
Naranjan S
St. Boniface
G.H.
Research
Centre
Role of Protease Activation in
Subcellular Remodeling in the
Heart.
Heart, ischemia-reperfusion,
calpain, nitric oxide,
sarcolemma.
20052008
$21,000
$63,000
I
Sirinyan,
Mirna
Chemtob,
Sylvain
McGill
University
Retinal endothelial cytotoxic
effects of sustained hypercapnia
in retinopathy of prematurity.
Retinopathy of immaturity,
hypercapnia, microvascular
degeneration, endothelial cell
death, reactive nitrogen species.
20042007
$21,000
$62,000
I
Song,
Dongzhe
Pang,
Catherine
CY
University
of British
Columbia
Effects of chronic Nacetylcysteine on insulin
resistance and blood pressure.
Antioxidant; insulin resistance;
hypertension; fructose.
20042007
$21,000
$62,000
I
Steinback,
Craig D
Shoemaker,
J Kevin
University
of Western
Ontario
Baroreflex-chemoreflex
interactions and sympathetic
nerve activity in cardiovascular
disease developement.
Baroreceptors, chemoreceptors,
sympathetic nerve activity, intermittent hypoxia, hypertension.
20052009
$21,000
$63,000
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
68
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Trudel, Eric
Bourque,
Charles W
Montreal
General
Hospital
Central mechanism underlying
circadian variations in the
osmoregulation of vasopressin.
Synaptic communication,
slices, patch-clamp, supraoptic
nucleus, Organum vasculum
lamina terminalis.
20042007
$21,000
$62,000
I
van der Veer,
Eric P
Pickering, J
Geoffrey
University
of Western
Ontario
Regulation of smooth muscle
cell longevity by pre-cell
colony-enhancing factor.
Vascular biology, smooth
muscle cells, aging, NAD.
20062008
$17,500
$26,250
I
Vasudevan,
Harish
McNeill,
John H
University
of British
Columbia
Androgen-dependent
regulation of arachidonic acid
metabolism influences the
development of hypertension
following insulin resistance.
Insulin resistance, hypertension,
sex hormones, endothelium
derived hyperpolarizing factor
(EDEF), 20-hydroxyeicosatetranoic acid (20-HETE).
20062009
$21,000
$63,000
I
Wassef,
Hanny
Davignon,
Jean
Clinical
Research
Institute of
Montreal
The role of apolipoprotein C-I
in adipose tissue.
Adipocyte, apolipoprotein C-I,
fatty acid metabolism,
adipokine, oxidation.
20062009
$21,000
$63,000
I, II
Weissgerber,
Tracey L
Adams,
Michael A
Queen’s
University
Effects of pregnacy, physical
activity and preeclampsia on
endothelial function and
biochemical indices of
oxidative stress and placental
dysfunction.
20062008
$21,000
$42,000
I, II
Xu, Yong
Krukoff,
Teresa L
University of
Alberta
Physiological and molecular
mechanisms for cardiovascular
effects of adrenomedullin in
the brain.
Adrenomedullin, arterial
pressure, baroreflex, nitric
oxide, calcium.
20052007
$9,250
$30,250
I
Zhang, Yun
Zhang, Xia
University
of Ottawa
Institute
of Mental
Health
Research
Poststroke treatment with
cannabinoid, neuronal
regeneration, stem/progenitor
cells.
Ischemic stroke, cannabinoid,
neuronal regeneration, stem/
progenitor cells.
20062010
$10,500
$63,000
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
69
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Research Fellowships | Bourses de perfectionnement en recherche
Awardee
Supervisor
Institute
Project
Keywords
Term
06-07 $
Total $*
Theme
Récipiendaire Directeur
Institut
Projet
Mots-clés
Durée
Akhavan,
Armin
Lingappa,
Vishwanath
University of
California
Subcellular mechanisms
involved in biogenesis and
secretion of Apolipoprotein B.
Translocation, signal sequence,
ApoB, biogenesis,
arteriosclerosis.
20042007
$20,000
$79,000
I
AugerMessier,
Mannix
Molkentin,
Jeffrey D
Cincinnati
Children’s
Hospital
Medical
Center
Quels rôles jouent respectivement les deux isoformes
de la calcineurin A dans
l’hypertrophie physiologique
et pathologique du coeur?
Calcineurin, NFAT, système
Cre-Lox, hypertrophie
cardiaque, cardiomyopathies.
20052007
40 000 $
80 000 $
I
Boivin,
Benoit
Tonks,
Nicholas K
Cold Spring
Harbor
Laboratory
Role of ROS and PTPs in RTKs
transactivation by GPCRs.
Hypertension, protein tyrosine
phosphatases, reactive oxygen
species, G-protein coupled
receptors, receptor tyrosine
kinases.
20062008
$40,000
$80,000
I
Brown,
Robert J
Rader,
Daniel J
University of
Pennsylvania
Characterization of endothelial
lipase exon variants associated
with elevated HDL cholesterol.
Polymorphisms, adenoassociated virus, atherosclerosis,
lipoproteins, lipases.
20062009
$20,000
$80,000
I
Busseuil,
David
Tardif,
JeanClaude
Institut de
cardiologie
de Montréal
Étude de la physiologie des
cellules endotheliales
progénitrices chez les patients
obèses métaboliquement
normales.
Cellules endotheliales
progenitrices, atherosclerose,
obeses metaboliquement en
sante, stress oxydatif, risque
cardiovasculaire.
20062008
40 000 $
80 000 $
I, II, IV
Chen, Yu
Noble, Earl
University
of Western
Ontario
The “danger signal” hypothesis: Heart failure, myocardial
a study on the role of
infarction, inflammation, heat
extracellular heat shock proteins shock proteins, immunity.
in triggering cardiovascular
inflammation.
20062007
$40,000
$40,000
I
Corteling,
Randolph L
Welsh,
Donald G
University of
Calgary
The role of heteromeric
G-proteins in the regulation
of cerebral arterial tone.
RNA interference, intact
vessels, G-proteins, Calcium
waves, contractions
20052007
$16,667
$36,667
I
Coutu, Pierre
Nattel,
Stanley
Montreal
Heart
Institute
Role of T-type calcium channel
in normal and diseased heart.
Cardiac hypertrophy, T-type
calcium channels, calcium
homeostasis, electrophysiology,
mathematical model.
20062007
$5,000
$5,000
I
Cummings,
Kevin James
Wilson,
Richard JA
University of
Calgary
Hypertension and peripheral
chemoreceptors: mechanisms
behind post-hypoxic decline in
carotid body activity.
Hypertension, breathing,
carotid body, neurotransmitters,
apnea.
20042007
$20,000
$79,000
I
DawsonScully,
Kenneth
Donald
Sokolowski,
Marla B
University of
Toronto
cGMP dependent protein
kinase, synaptic transmission
and food related behaviours of
drosophila.
Drosophila melanogaster,
synaptic transmission, cGMP,
PKG, feeding behaviour.
20052007
$40,000
$80,000
I
Dolinsky,
Vernon
Dyck, Jason University of
RB
Alberta
AMPK activation for the
treatment of insulin resistance.
Skeletal muscle metabolism,
AMPK, insulin resistance,
diabetes.
20062008
$40,000
$80,000
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
70
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Institute
Project
Keywords
Term
Récipiendaire Directeur
Institut
Projet
Mots-clés
Durée
Duez, Hélèn
Lewis,
Gary F
Toronto
General
Hospital
The effect of dipeptidyl
peptidase (DPP)-IV inhibition
on carbohydrate and lipid
metabolism.
Diabetes, insulin secretion,
GLP-1, incretins, dipeptidyl
peptidase (DPP) IV inhibitor.
20052007
$40,000
$80,000
I
Duhamel,
Todd A
Dhalla,
Naranjan S
St. Boniface
Characterization of disease
G.H. Research mechanisms associated with
Centre
diabetic cardiomyopathy
induced by type 2 diabetes.
Diabetic cardiomyopathy,
cardiovascular disease, cellular
remodelling, calcium regulation,
protein phosphorylation.
20062009
$33,333
$80,000
I
Dupre, Denis
J
Hébert,
Terence E
Montreal
Heart
Institute
Characterization of the
ontogeny and trafficking of
G-protein coupled receptor
complexes.
G-protein coupled receptors,
hetero-dimerization, trafficking,
complex assembly, bioluminescence resonance energy
transfer technology.
20052007
$40,000
$73,333
I
El-Hamamsy,
Ismail
Yacoub,
Magdi H
Imperial
College
London
Molecular and cellular
responses to mechanical forces
in the pulmonary valve.
Heart valves, tissue engineering,
interstitial cells, myofibroblasts.
20062007
$16,667
$16,667
I, II
Fan, Xiaohu
West, Lori J
Hospital for
Sick Children
Induction of B cell tolerance to
ABH blood group antigens by
gene therapy.
ABO-incompatible heart
transplantation, B cell tolerance,
gene therapy, lentiviral vector,
human ABO blood type A
transgenic mice.
20052007
$40,000
$80,000
I
Gélébart,
Pascal
Michalak,
Marek
University of
Alberta
Calreticulin and cardiac
development.
Cardiac differentiation,
stem cells, calreticulin, Ca
homeostasis.
20042007
$20,000
$79,000
I
Hale, Taben
M
deBlois,
Denis
Université de
Montréal
Therapeutic apoptosis confers
long-term protection against
target organ damage.
Apoptosis, hypertension,
stroke, myocardial infarction,
fibrosis.
20062009
$30,000
$80,000
I
Hurtado,
Cecilia
De
Robertis,
Edward M
Howard
Hughes
Medical
Institute
Gene-enhanced therapies for
ischemic heart disease.
20042007
$20,000
$79,000
I
Jaffe, Ronen
Strauss,
Bradley H
St. Michael’s
Hospital
Microvessel formation in
chronic total occlusions:
pathophysiology and role in
guide-wire crossing.
Magnetic resonance imaging,
micro CT, chronic total occlusion, cell therapy, percutaneous
coronary angioplasty.
20062007
$50,000
$50,000
I, II
Javeshghani,
Danesh
Touyz,
Rhian M
Institut de
recherches
cliniques de
Montréal
Development of hypertension
in follitropin receptor knockout
mouse, potential implications
for women’s health.
Cardiovascular, oxidative stress,
estrogen, angiotensin II,
hypertension.
20042007
$20,000
$79,000
I
Jung,
Eubanks,
James H
Toronto
Western
Research
Institute
Characterization of GIG-11, a
novel ischemia-induced gene,
in neurodegeneration.
Protein-interactions,
phosphorylation, signal
transduction, apoptosis.
20042007
$38,333
$79,917
I
St. Michael’s
Hospital
Endothelial cell apoptosis in
Pulmonary arterial hypertension,
pulmonary arterial hypertension. endothelium, apoptosis.
20062008
$40,000
$80,000
I
Benjamin
Supervisor
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Jurasz, Paul K Stewart,
Duncan J
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
71
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Supervisor
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Institute
Project
Keywords
Term
Récipiendaire Directeur
Institut
Projet
Mots-clés
Durée
Karasinska,
Joanna
Monika
Hayden,
Michael R
University
of British
Columbia
Role of neuronal and glial
ABCA1 in the response to
neuronal injury.
Cholesterol, ATP-binding
cassette transporter, brain lipid
metabolism, neuronal repair,
animal model.
20062009
$33,333
$80,000
I
Kinobe,
Robert T
Melo, Luis
G
Queen’s
University
Investigations of distinctive
neuroprotective role of heme
oxygenase isozymes in cerebral
ischemia.
Carbon monoxide, heme
oxygenase, cerebral ischemia,
stroke.
20062009
$16,667
$80,000
I, II, III,
IV
Koonen,
Debby
Dyck, Jason University of
RB
Alberta
The role of FAT/CD36 in the
regulation of fatty acid
utilization in the heart.
CD36, AMPK, ischemia/
reperfusion, fatty acid uptake,
heart.
20052007
$40,000
$80,000
I
Lee, SangWook
Steinman,
David A
Robarts
Research
Institute
Beyond normal: turbulence at
the diseased carotid bifurcation
and risk of stroke.
Stroke, stenosis, blood flow
dynamics, carotid artery,
doppler ulatrasound.
20062008
$40,000
$66,667
I, II
Lehmann,
Hugo E
Sutherland,
Robert J
University of
Lethbridge
The effects of hippocampal
neural death and regrowth on
memory.
Neuronal death, hippocampus,
memory, neurogenesis.
20052008
$40,000
$80,000
I, II
Lin, Danny
Chi-Chia
Kaplan,
David
Hospital for
Sick Children
High-throughput shRNA
screening to identify regulators
of dendrite formation in cortical
neurons.
Dendrite formation,
high-throughput screening,
regeneration.
20062008
$40,000
$80,000
I
Lynch, Jeffrey Molkentin,
M
Jeffrey D
Children’s
Medical
Center
Determination of the role of
MEF2A and MEF2D in cardiac
hypertrophy.
Cardiac hypertrophy, myocyte
enhancer factor 2 (MEF2),
transcription.
20052008
$40,000
$80,000
I
Mungrue,
Imran
Lusis,
Aldons J
University of
California
Examination of the role of
TXNIP in atherosclerosis and
lipid metabolism.
Atherosclerosis, TXNIP, mouse
models, protein building, mechanisms of metabolic disease.
20062008
$40,000
$80,000
I
Naus, Silvia
Ziltener,
Hermann J
University
of British
Columbia
The role of metalloproteases in
the leukocyte homing process.
Metalloproteases, ADAM,
mucin-like receptors, immune
cells.
20062009
$20,000
$80,000
I
Palanivel,
Rengasamy
Sweeney,
Gary
York
University
Regulation of carbohydrate and
lipid uptake in cardiomyocytes
by adiponectin.
Obesity, heart failure, cardiac
remodeling, adiponectin,
metabolism.
20062008
$40,000
$80,000
I
Pulinilkunnil,
Thomas
Chacko
Kahn,
Barbara B
Beth Israel
Deaconess
Medical
Center
Role of the AMPK pathway
and upstream kinases in the
metabolic effects of adipokines
and adrenergic agonists in white
adipose tissue.
AMPK, type 2 diabetes, obesity,
CAMKK, heart.
20062008
$40,000
$80,000
I
Qu, Yang
(Tiffany)
Tibbits,
Glen F
Simon Fraser
University
The automaticity of mouse
embryonic stem cell derived
cardiomyocytes.
Embryonic stem cells, cardiac
differentiation, pacemaker channels, targeted gene deletion,
sodium/calcium exchanger.
20062008
$40,000
$80,000
I
Rose, Robert
A
Backx,
Peter H
University of
Toronto
Role of P13Kinase-gama in
heart rate regulation and in
heart disease.
Ion channels, heart disease,
contractility, calcium,
transgenics, mouse.
20052007
$40,000
$80,000
I, II
Ruest, LouisBruno
Clouthier,
David E
University of
Louisville
Endothelin-A receptor signalling
during cardiac neural crest cell
development.
Cardiac neural crest cell,
knockout mice, DNA microarray, antagonist, development.
20042007
$6,667
$78,333
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
72
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Supervisor
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Institute
Project
Keywords
Term
Récipiendaire Directeur
Institut
Projet
Mots-clés
Durée
Sapieha,
Przemyslaw
Chemtob,
Sylvain
McGill
University
Secretory phospholipase A2
receptors in ischemic
neuropathies.
Secretory phospholipase A2,
vascular degeneration,
inflammatory mediators,
ischemic retinopathies,
oxidative stress.
20062008
$40,000
$80,000
I
Sidhu,
Ranjinder S
Smith,
William L
University of
Michigan
Cyclooxygenase pathways and
omega-3 fatty acids.
Cyclooxygenase, peroxidase,
catalysis, mechanism.
20062008
$40,000
$80,000
I
Silverman
Gavrila,
Lorelei B
Charlton,
Milton P
University of
Toronto
The role of synaptic plasticity and phosphorylation in
neruoprotection and survival
from ischemic cerebellar stroke.
Ischemic stroke, cerebellum,
phosphorylation, synaptic
plasticity, neuroprotection and
survival.
20062008
$40,000
$80,000
I, II
Singaraja,
Roshni R
Hayden,
Michael R
University
of British
Columbia
The role of palmitoylation in the
functional activity of ABCA1.
Palmitoylation, lipid,
atherosclerosis, efflux,
trafficking.
20052007
$40,000
$80,000
I
Storbeck,
Sabourin,
Christopher J Luc A
University of
Ottawa
Investigation of the role of
CLIM 2 in MLP mediated
cardiomyopathy.
Hypertrophy, dilated
cardiomyopathy, MLP, CLIM2.
20052008
$40,000
$80,000
I, II, IV
Tedford,
Hugo W
Zamponi,
Gerald W
University of
Calgary
Molecular determinants of Gprotein mediated regulation of
N-type calcium channels.
Calcium channel,
electrophysiology, pain
management, heterotrimeric
G proteins.
20052007
$36,667
$70,000
I, II
Tilley,
Douglas G
Rockman,
Howard A
Duke
University
The role of phosphoinositide 3
kinase in the beta-adrenergic
receptor-mediated transactivation of epidermal growth factor
receptor in the normal and
failing heart.
Heart failure, beta adrenergic
receptors, epidermal growth
factor receptor, transactivation,
phosphoinositide 3 kinase.
20062008
$40,000
$80,000
I
Varela
Lekanda,
Diego Ernst
Zamponi,
Gerald W
University of
Calgary
Molecular determinants of T-type Biophysic, electrophysiology,
calcium channel inactivation and calcium channel.
its physiological significance.
20062009
$33,333
$80,000
I
Vieira,
Luciene
Bruno
Zamponi,
Gerald W
University of
Calgary
Modulation of N-type calcium
channel function by the small
GTPase Rem2.
20062008
$20,000
$33,333
I
Xaymardan,
Munira
Li, Ren-Ke
University of
Toronto
Pretreatment of bone marrow
Myocardial infarction, bone
cells with VEGF and FGF
marrow, cardiac regeneration,
augments the myogenic diffeVEGF, FGF.
rentiation and engraftment of the
cells into infarcted myocardium.
20062009
$3,333
$80,000
I
Yang,
Guangdong
Wang, Rui
University of
The physiological role of
Saskatchewan endogenous hydrogen sulfide
in the regulation of smooth
muscle cell proliferation and
apoptosis.
Hydrogen sulfide, vascular
smooth muscle cells
cystathionine gamma-lyase,
proliferation, apoptosis.
20052008
$40,000
$80,000
I
Zhang,
Yiqiang
Marban,
Eduardo
Johns
Hopkins
University
Cardiac stem cell, electrophysiology, developmental cell
biology, cardiac marker genes,
cardiac infarction.
20062008
$40,000
$80,000
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
Developmental ionic and
molecular basis of cardiac stem
cells in cardioregeneration.
II: Clinical
II : Clinique
Patch-clamp, confocal
microscopy, electrophysiology,
calcium channels, synaptic
transmission.
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
73
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
New Investigators | Bourses de nouveaux chercheurs
Awardee
Institute
Project
Keywords
Term
Projet
Mots-clés
Durée
Poly(ADP-ribose) polymerase,
excitotoxicity, astrocytes, glutamate
transport.
06-07 $
Total $*
20052010
$50,000
$250,000
I
Barber, Philip University of Magnetic resonance molecular imaging Stroke, magnetic resonance imaging,
A
Calgary
(MRMI) of the early endothelial
neuroinflammation.
inflammatory response in focal
ischemia.
20052010
$50,000
$265,000
I
Childs, Sarah
J
University of Blood vessel development in zebrafish.
Calgary
Angiogenesis, development, zebrafish, genomic, molecular biology.
20012007
$4,167
$250,000
I
Colicos,
Michael A
University of Role of neuroligin during
Calgary
photoconductive stimulation-driven
synaptic reorganization of mammalian
neuronal networks.
Ischemia, synaptic reorganization,
neuronal cultures, neurosilicon
interface, neuroligin.
20062011
$65,000
$265,000
I
Czubryt,
Michael P
University of Roles of MEF2 and HDAC5 in cardiac
Manitoba
failure and hypertrophy.
Transcriptional regulation, cardiac
hypertrophy, molecular biology, sexual
dichotomy, transgenic mice.
20042009
$50,000
$265,000
I
Dawson,
John F
University of Characterization of human cardiac actin Cardiac actin mutations, hypertrophic
Guelph
mutations linked to hypertrophic and
and dilated cardiomyopathy, protein
dilated cardiomyopathies.
expression and manipulation, actin
binding assays.
20042010
$50,000
$250,000
I
Devlin,
Angela M
University
of British
Columbia
Nutrition, epigenetics & risk for
cardiovascular disease.
Hyperhomocysteinemia, DNA
methylation, mice, nutrition, gene
expression.
20062011
$65,000
$265,000
I, II, IV
Drolet,
Benoit
Université
Laval
The modulating effects of diabetes,
obesity and genetics on the electrophysiology of QT-prolonging drugs.
Electrophysiology, obesity, diabetes,
patch-clamp, TW-prolonging drugs.
20042009
$50,000
$250,000
I
FernandezPatron,
Carlos A
University of New vasoconstrictor mechanism
Alberta
triggered by transactivation of a
growth pathway.
Vascular, epidermal growth factor
receptor, transactivation, G-protein
coupled receptor.
20022007
$50,000
$250,000
I
Gramolini,
Anthony
University of Molecular basis of PLN regulation and
Toronto
function in cardiac muscle.
Calcium, serca, mouse models,
phospholamban, cardiac, sarcoplasmic reticulum.
20062011
$50,000
$250,000
I, II
Jacques,
Danielle
Université
de
Sherbrooke
Regulation of intracellular calcium by
NPY in endocardial endothelial cells.
Neuropeptide Y, endocardial
endothelium, confocal microscopy,
receptor mapping, intracellular
calcium.
20022008
$50,000
$250,000
I
Liaw, Patricia
CY
McMaster
University
Modulation of inflammation and
apoptosis by activated protein C, a
natural anticoagulant.
Coagulation, inflammation, apoptosis,
thrombosis, activated protein C,
vascular biology, endothelial cells,
blood monocytes, leukocytes, signal
transduction pathways, proteaseactivated receptors, biochemistry,
cell biology, molecular biology,
translational studies of patient blood
samples, in vivo animal models.
20032009
$50,000
$250,000
I
Récipiendaire Institut
Anderson,
Christopher
M
University of PARP1 effects on bioenergetics and
Manitoba
glutamate homeostasis in brain.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
74
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Institute
Récipiendaire Institut
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Project
Keywords
Term
Projet
Mots-clés
Durée
06-07 $
Total $*
Theme
Thème
MacDonald,
Justin A
University of Characterization of CHASM
Calgary
involvement in cGMP-evoked calcium
desensitization in vascular smooth
muscle.
Calcium desensitization, smooth
muscle tone, nitric oxide, cGMPdependent protein kinase, signal
transduction.
20042009
$50,000
$250,000
I
Mak,
Susanna
Mount Sinai
Hospital
Estrogen and cardiac function in
humans with and without heart failure.
Sex, estrogen, ventricular function,
heart failure.
20052010
$50,000
$250,000
II
Melacini,
Giuseppe
McMaster
University
Structural basis for the cAMP-signal
translation in PKA by NMR.
Signalling, kinase, cAMP, allostery,
NMR.
20062011
$50,000
$250,000
I
Melo, Luis G
Queen’s
University
Gene therapy for long term myocardial
protection and rescue.
Myocardium, echocardiography,
hemodynamic measurements,
histology.
20022007
$50,000
$250,000
I
Miller,
Gregory E
University
of British
Columbia
Depression, inflammation, and risk for
coronary heart disease.
Depression, behavioral cardiology,
inflammation, coronary heart disease,
metabolic syndrome.
20052010
$50,000
$265,000
II, IV
Pasumarthi,
Kishore
Babu S
Dalhousie
University
Isolation and characterization of cardiac Transgenic mice, embryonic stem
progenitor cells.
cells, cardiac progenitor cells, gene
expression, cardiac repair.
20032008
$50,000
$250,000
I
Peng,
Tianqing
Lawson
Research
Institute
PLCgamma/IP3 signaling regulates
cardiac TNF-a expression in sepsis.
Sepsis, TNF-alpha, cardiomyocyte,
phospholipase Cgamma, inositol
trisphosphate.
20062011
$50,000
$250,000
I
Pyle, William
Glen
University of The role of cardiac Z-disc in signal
Guelph
transduction and myocardium.
Actin capping protein, intracellular
signalling, muscle mechanics,
cytoskeleton, heart failure.
20052010
$50,000
$250,000
I
Reid, Robert
D
University of Interventions to promote physical
Ottawa
activity for the secondary prevention
of CAD.
Physical activity, CAD.
20022007
$50,000
$250,000
IV
Rodger,
Marc A
University of Thrombophilia: novel associations and
Ottawa
therapeutic interventions.
Thrombophilia, pregnancy, randomised
controlled trial, hemodialysis access,
thrombosis, case control study.
20022007
$50,000
$250,000
II
Trigatti,
Bernardo L
McMaster
University
Effect of tissue specific expression or
suppression of the HDL receptor SR-BI
on cardiovascular disease.
Transgenic, knockout, HDL receptor,
atherosclerosis, coronary artery disease.
20022007
$50,000
$250,000
I
Wang, Hui Di Brock
University
Vascular gp-91phox containing NADPH
oxidase in angiotensin II-induced
hypertension.
NADPH oxidase, angiotensin II,
endothelin-1, hypertension,
hypertrophy.
20022007
$50,000
$250,000
I
Werstuck,
Geoffrey H
McMaster
University
Mechanisms by which diabetes mellitus
promotes the development and
progression of atherosclerosis.
Atherosclerosis, diabetes mellitus,
endoplasmic reticulum, molecular and
cellular biology, mouse models.
20042009
$50,000
$250,000
I
Zha, Xiaohui
Ottawa
Hospital
Research
Institute
ABCA1 and molecular mechanism of
cholesterol efflux.
ABCA1, cholesterol, fluorescent
microscopy, membrane, trafficking.
20032008
$50,000
$250,000
I
Zhang,
Shetuan
St. Boniface
G.H.
Research
Centre
The mechanisms of sudden cardiac
death caused by cocaine.
Myocardium, emergency cardiac
care, electrophysiology, molecular
biological techniques, cardiac
dysrrhythmias.
20042008
$50,000
$183,333
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
75
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Visiting Scientist | Bourse de chercheur invité
Awardee
Sponsor
Récipiendaire Parrain de la
Institute
Project
Keywords
Term
Institut
Projet
Mots-clés
Durée
University
of British
Columbia
Contribution of gap junctional
communication in the neuroprotective
role of astrocytes.
Stroke, neuroprotection,
astrocytes, gap junctions,
connexin.
06-07 $
Total $*
Theme
Thème
demande
Naus,
Christian
Giaume,
Christian
20062007
$8,200
$8,200
I
Nursing Research Fellowships | Bourses de perfectionnement en sciences infirmières
Awardee
Supervisor
Institute
Project
Keywords
Term
Récipiendaire
Directeur
Institut
Projet
Mots-clés
Durée
Carroll,
Sandra Lee
Arthur,
Heather M
McMaster
University
Uncertainty and optimism in patients
receiving implantable defibrillators.
Implantable defibrillators,
uncertainty, optimism,
quality of life.
20052008
$25,000
$75,000
II
Lapum,
Jennifer L
Angus,
Jan E
University
of Toronto
Narratives of technological health
care: patients’ reconstruction of selfidentity following open-heart surgery.
Heart surgery, experiences,
technology, self-identity,
narratives.
20052008
$25,000
$75,000
II
Lauck, Sandra
B
Johnson,
Joy
University
of British
Columbia
How does early discharge following
elective same-day discharge
angioplasty affect patient outcomes?
Coronary artery disease,
percutaneous coronary
intervention (PCI), early discharge, patient outcomes.
20062008
$25,000
$50,000
II, III
McLean,
Donna L
Tsuyuki,
Ross T
University
of Alberta
Detection and management of
hypertension in patients with diabetes
in the community.
Detection, management,
hypertension, diabetes,
community.
20042007
$25,000
$75,000
III
Parry, Monica
JE
WattWatson,
Judy
University
of Toronto
Impact of a home-based intervention
on health-related quality of life,
function, and symptom management
for people following coronary artery
bypass graft surgery.
Health related quality of
life (HRQOL), peer support,
symptom management,
functional status, coronary
artery bypass graft surgery.
20042007
$25,000
$75,000
II
University
of Toronto
Can structured-coaching increase intake Cardiac rehabilitation,
and uptake of cardiac rehabilitation in
access, women.
female cardiac patients?
20062009
$25,000
$75,000
II, III
Price, Jennifer Doran,
AD
Diane
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
76
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Industry-Supported Research Personnel
Awards
Bourses de fonctionnement en recherche
financées par l’industrie
The HSF wishes to thank the following industry supporters for their
generous contributions to support the HSF Research Program.
La FMC souhaite remercier les entreprises suivantes pour leur généreuse
contribution au soutien de son programme de recherche.
Awardee
Supervisor
Récipiendaire Directeur
Institute
Project
Keywords
Institut
Projet
Mots-clés
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $
HSF
FMC
Total $ (All
Partners)
(tous les
partenaires)
Theme
Thème
HSF/CIHR/AstraZeneca Clinical Research Fellowship | Bourse de perfectionnement en recherche clinique FMC/IRSC/AstraZeneca
Casaubon,
Leanne K
Kapral,
Moira K
Toronto
General
Hospital
Evaluation of the
effect of acute
hyperglycemia on
stroke outcomes.
Stroke, hyperglycemia, outcomes
research, registries,
data linkage.
20062007
$16,667
$50,000
$16,667
$50,000
II, III
Koshy, Susan
M
Logan,
Alexander
G
Mount
Sinai
Hospital
Predictors of
cardiovascular
outcomes and
death in pediatric
renal transplant
recipients.
Myocardial
infarction, stroke,
renal transplant,
pediatric,
longitudinal.
20062008
$16,667
$50,000
$22,222
$66,667
II
HSF/AstraZeneca Research Fellowship | Bourse de perfectionnement FMC/AstraZeneca
Bussiere,
Miguel
Hachinski,
Vladimir
University
of
Western
Ontario
Cerebral and
systemic consequences of
carotid stenting.
Karwatsky,
Joel
Zha,
Xiaohui
Ottawa
Health
Research
Institute
The influence of
ATP-binding
cassette protein
A1 (ABCA1)
on cholesterol
export.
Lapointe,
Benoit
Kubes, Paul
University
of
Calgary
In vivo leukocyte
trafficking and
emigration in a
model of stroke.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Carotid, stenting,
physiology,
autonomic,
cognition.
20062008
$0
$50,000
$0
$100,000
I, II
Cholesterol,
20062009
$0
$33,333
$0
$80,000
I
20052008
$30,000
$40,000
$40,000
$80,000
I
coronary heart
disease, membrane trafficking,
ABC transporters,
ATP-binding
cassette protein
A1 (ABCA1).
Stroke, chemotaxis, emigration,
recruitment,
leukocyte.
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
77
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Supervisor
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Institute
Project
Keywords
Récipiendaire Directeur
Institut
Projet
Mots-clés
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $
HSF
FMC
Total $ (All
Partners)
(tous les
partenaires)
Theme
Maekawa,
Yuichiro
Liu, Peter P
Toronto
General
Hospital
Roles of interleukin-1 signaling pathways in
left ventricular
remodeling after
acute myocardial
infarction.
Heart failure,
myocardial
infarction,
knockout models,
cytokines,
immunity.
20062008
$0
$40,000
$0
$51,667
I, II
Overgaard,
Christopher
B
Newton,
Gary E
University
of
Toronto
Free radical
modulation of
mechanical efficiency in heart
failure.
Heart failure,
free radicals,
mechanical
efficiency.
20052008
$25,000
$50,000
$50,000
$100,000
II
Thème
HSF/Great-West Life and London Life Research Award | Bourse de recherche FMC/Great-West Life et London Life
Whitman,
Stewart C
N/A
University
of Ottawa
Heart
Institute
The role of the
immune system
in atherosclerosis:
mechanism of
action of IL-12
and IL-18.
Atheros-clerosis,
immunology,
apoE-/- mouse,
cytokines.
20032007
$60,000
$60,000
$120,000
$250,000
I
$25,000
$25,000
$98,750
$146,250
II
HSF/Merck Frosst Research Fellowship | Bourse de perfectionnement FMC/Merck Frosst
Spears,
Julian
Wallace, M
Christopher
Toronto
Western
Hospital
Development
of a prediction
model for neurological outcome
following surgery
of brain AVMs in
the prevention
of hemorrhagic
stroke.
Stroke,
prevention, brain
arteriovenous
malformations,
surgery, outcome
measures.
20032007
HSF/Pfizer Canada Research Fellowship | Bourse de perfectionnement FMC/Pfizer Canada
Comtois,
Philippe
Nattel,
Stanley
McGill
University
Role of tissue
fibrosis in atrial
fibrillation.
Congestive heart
failure, atrial
fibrillation,
mathematical
modeling,
epicardial
mapping, tissue
remodeling.
20062008
$0
$40,000
$20,000
$60,000
I
Paquet,
Maryse
Ferguson,
Stephen
SG
Robarts
Research
Institute
Role of astrocytic
and neuronal
mGluR5 and
GRK2-mediated
desensitization in
excitotoxicity.
Excitotoxicity,
GRK2, mGluR5,
astrocytes,
neurons.
20062007
$0
$36,667
$0
$36,667
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
78
Heart and Stroke Foundation | Research Report 2006-2007
Awardee
Supervisor
Récipiendaire Directeur
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Institute
Project
Keywords
Institut
Projet
Mots-clés
Term
06-07 $
Durée HSF
FMC
Total 06-07 $
(All Partners)
(tous les
partenaires)
Total $
HSF
FMC
Total $ (All
Partners)
(tous les
partenaires)
Theme
Thème
HSF/Sanofi-aventis Research Fellowship | Bourse de perfectionnement FMC/Sanofi-aventis
Bouchard,
Luigi
Vohl, Marie- Université Genomic insights
Claude
de Laval
into the metabolic syndrome.
Visceral obesity,
DNA microarrays,
differential gene
expression.
20052007
$40,000
$40,000
$40,000
$80,000
I, IV
$40,000
$40,000
$120,000
I
HSF/Transamerica Life Canada Research Award | Bourse de recherche FMC/Transamerica Vie Canada
Cimini,
Massimo
Li, Ren-Ke
Toronto
General
Hospital
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
Construction of
tissue engineered
grafts for cardiac
repair.
II: Clinical
II : Clinique
Tissue engineered
cardiac grafts,
cardiomyocytes,
smooth muscle
cells, skeletal
muscle cells, bone
marrow derived
mesenchymal
stem cells.
20052008
$0
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
79
APPENDIX
Annexe
C
GRANTS-IN-AID BY PROVINCE
SUBVENTIONS PAR PROVINCE
Dr. Jean-Pierre Després (Hôpital Laval) was part of research teams in 2006-2007 receiving Grant-in-Aid awards from the Heart and Stroke Foundation of
Québec, including an award titled Metabolic determinants of the progression of aortic stenosis.
Dr Jean-Pierre Després (Hôpital Laval) faisait partie des équipes de recherche qui, en 2006-2007, étaient financées par la Fondation des maladies du
cœur du Québec, notamment par l’entremise d’une bourse pour le projet Facteurs métaboliques de la progression de la sténose aortique.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
British Columbia/Yukon | Colombie-Britannique / Yukon
06-07 $
Total $*
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Accili, Eric A
University of
British Columbia
Interactions among pacemaker
channel isoforms and auxiliary
proteins.
Pacemaker channels,
co-assembly, cell surface
expression.
20062009
$125,000
$375,000
I, II
Accili, Eric A
University of
British Columbia
Molecular and cellular
mechanisms of HCN channel
function.
Hyperpolarization-activated
channels, structure-function,
trafficking, gating, permeation.
20042007
$102,250
$303,274
I
Burtnick, Leslie D
University of
British Columbia
The structure of gelsolin-capped
actin filaments.
Actin, gelsolin, thymosin
beta4, tropomyosin, x-ray
crystallography.
20052008
$16,279
$48,284
I
Church, John
University of
British Columbia
Ischemia and the regulation of
intracellular ion homeostasis in
hippocampal neurons.
Cerebral ischemia, intracellular
ion homeostasis, sodium/
hydrogen exchange, chloride/
bicarbonate exchange,
sodium/bicarbonate
cotransport.
20052008
$54,497
$173,491
I
Cupples, William A
University of
Victoria
Consequences of the salt paradox
in diabetes mellitus.
Diabetes mellitus, blood
pressure, autoregulation,
nephropathy, salt paradox.
20052008
$42,322
$127,030
I
Davies, Hugh W;
Demers, Paul A;
Ostry, Aleck S; Levy,
Adrian R
University of
British Columbia
Exposure to noise at work and
cardiovascular disease: a study of
the temporal association, interactions among exposure agents,
and susceptible populations.
20052008
$46,778
$123,673
IV
Eng, Janice J
University of
British Columbia
Exercise programs in stroke.
Rehabilitation, health services,
upper extremity function,
exercise, recovery.
20062009
$112,192
$336,504
III
Fedida, David
University of
British Columbia
Activation and inactivation gating
of cardiac voltage-gated potassium
channels studied by electrophysiology and time-resolved fluorescence changes.
Potassium channel, heart,
fluorescence, arrhythmia,
electrophysiology.
20062011
$156,844
$750,680
I
Fedida, David
University of
British Columbia
Contribution of the dynein motor
system to surface expression and
subcellular localization of voltagegated potassium channels.
Potassium channel, heart,
dynein motor, arrhythmia,
electrophysiology.
20052010
$122,740
$619,079
I
Granville, David J;
Laher, Ismail
St. Paul’s Hospital
Role of CYP2C9 in peri-transplant
ischemic injury.
20052008
$72,529
$217,551
I
Hayden, Michael R
University of
British Columbia
The molecular mechanisms
underlying the improved
lipoprotein profile of LPL-S447X
and its use for the treatment of
lipoprotein lipase deficiency.
20042007
$12,954
$38,422
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
82
Lipoprotein lipase, gene
therapy, triglycerides, HDL,
cholesterol.
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
06-07 $
Total $*
Theme
Thème
co-chercheur(s)
principal
Hill, John S
St. Paul’s Hospital
Functional analysis of lipase
gene expression in human
macrophages.
Endothelial lipase, hepatic
lipase, macrophages, atherosclerosis, RNA interference.
20052008
$34,690
$102,855
I, II
Hill, John S;
Frohlich, Jiri J;
Chan, Sammy Y
St. Paul’s Hospital
Evaluation of the relative
predictive value of biomarkers of
oxidative stress for cardiovascular
mortality.
Oxidative stress, risk factors,
angiography, coronary artery
disease, mortality.
20062008
$108,127
$216,218
I, II
Humphries, Karin
H; Kerr, Charles R;
Bernstein, Victoria;
Cook, Richard; Gin,
Kenneth G; Slavik,
Richard
University of
British Columbia
Magnesium for the prevention
of atrial arrhythmias after cardiac
surgery (M-PAACS).
20042007
$63,000
$420,851
II
Johnson, Pauline
University of
British Columbia
To investigate the pro- and
anti- inflammatory functions of
CD44 and hyaluronan.
Inflammation, cell adhesion
molecules, CD44, hyaluronan,
macrophages.
20062009
$80,490
$160,454
I
Karsan, Aly
BC Cancer
Research Centre
Mechanisms of ischemic
neovascularization.
Endothelial cells, vascular
smooth muscle, endothelialmesenchymal transformation,
notch, snail.
20042009
$108,470
$321,722
I
Karsan, Aly
BC Cancer
Research Centre
Molecular mechanisms of
endothelial survival/apoptosis.
Apoptosis, endothelium,
notch, signal transduction,
vascular injury.
20062011
$129,747
$129,747
I
Krassioukov, Andrei
V; Ramer, Matthew
S; Norenberg,
Michael D
University of
British Columbia
Episodic hypertension following
spinal cord injury: the role of
peripheral sympathetic-sensory
interactions in animal models and
humans.
Autonomic dysreflexia, blood
pressure control, human,
sympathetic preganglionic
neurons, spinal cord injury.
20062009
$75,853
$209,005
I
Laher, Ismail
University of
British Columbia
Cigarette smoking and resistance
artery function.
Resistance artery, endothelium,
myogenic tone, pharmacology,
cerebral artery, signaling,
coronary artery, calcium.
20042007
$91,413
$271,131
I
Laher, Ismail
University of
British Columbia
Lifestyle modifications improve
coronary artery function in type 2
diabetes.
Diabetes, endothelium,
superoxides, coronary artery,
mouse.
20062009
$87,528
$262,512
I, II,
III, IV
Leroux, Michel R
Simon Fraser
University
Analysis of genes linked to
cardiovascular disease.
Bardet-Biedl syndrome, BBS
proteins, Alstrom syndrome,
cilia, cardiovascular health.
20052010
$98,711
$499,859
I
MacLeod, Kathleen
M
University of
British Columbia
Activation of PKC and induction
of iNOS in diabetic arteries:
mechanisms and significance.
Diabetes, vasoconstriction,
PKC, rho kinase, iNOS.
20062007
$42,384
$42,384
I
MacVicar, Brian A
University of
British Columbia
Cellular mechanisms underlying
ischemia induced neuronal
necrosis.
Brain slice, necrosis, pannexin,
TRP channel, intracellular
calcium.
20062009
$106,500
$319,500
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
83
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
06-07 $
Total $*
Theme
Thème
co-chercheur(s)
principal
McManus, Bruce M;
Luo, Honglin
St. Paul’s Hospital
Intracellular signalling networks in
cardiotropic enteroviral infections.
Coxsackievirus B3, intracellular
signalling networks,
extracellular signal-regulated
kinase, viral myocarditis,
proinflammatory cytokine.
20062009
$100,400
$301,200
I
McManus, Bruce M;
Rahmani, Maziar ;
Knight, Darryl A
St. Paul’s Hospital
Role and regulation of
proteoglycan, versican, in vascular
injury and repair.
Beta-catenin, T cell factor
transcription factors, vascular
injury and repair, proteoglycans, and versican.
20052008
$85,000
$256,734
I
McNagny, Kelly M
University of
British Columbia
The role of endoglycan in
hematopoiesis, vascular biology
and cancer.
CD34, adhesion, vascular
permeability, cell migration.
20042007
$95,537
$283,363
I
McNeill, John H
University of
British Columbia
Modulation of cardiac metabolism
by metoprolol in the diabetic
heart.
Cardiomyopathy, heart
failure, cardiac metabolism,
beta-blockers, diabetic
complications.
20062009
$107,809
$323,427
I
Miller, William C;
Eng, Janice J
University of
British Columbia
Fear of falling after stroke.
Fear of falling, falling, stroke,
aging, balance confidence.
20042007
$54,505
$173,448
II
Moore, Edwin DW
University of
British Columbia
The structure of excitationcontraction coupling in atrial
and ventricular muscle.
20062009
$8,000
$23,928
I
Murphy, Timothy H
University of
British Columbia
Protection against neuronal oxida- Glutamate, oxidative stress,
tive stress by glial glutathione.
stroke, glutathione, glia.
20042007
$83,850
$248,699
I
Naus, Christian CG;
Krebs, Claudia
University of
British Columbia
Gap junctions and
neuroprotection in stroke.
Gap junctions, transgenic,
knockout, connexin, stroke.
20052010
$87,000
$431,934
I
Pang, Catherine CY;
Kuo, Kuo-Hsing
University of
British Columbia
Pharmacology of vasoactive
substances.
In vivo, urocortin, blood
pressure, venous system,
morphology.
20062007
$42,384
$42,384
I
Proud, Christopher
G
University of
British Columbia
Control of protein synthesis in
cardiac myocytes.
Signaling, mTOR, protein
synthesis, cardiac hypertrophy,
protein kinase.
20052008
$108,660
$331,910
I
Pryzdial, Edward LG
University of
British Columbia
Coagulation initiated on herpes
viruses.
Coagulation, fibrinolysis, herpes, thrombosis, biochemistry.
20062009
$112,884
$338,652
I
Pryzdial, Edward LG
University of
British Columbia
Effects of plasmin on
prothrombinase.
Coagulation, fibrinolysis, factor
X, factor V, biochemistry.
20042007
$104,455
$309,814
I
Rodrigues, Brian B
University of
British Columbia
Cardiac abnormalities in n-6 PUFA
fed diabetic rats.
Polyunsaturated fatty acids,
diabetes, cardiolipin,
glutathione, necrosis.
20052008
$60,169
$180,507
I
Sanatani,
Shubhayan;
Etheridge, Susan
P; McCrindle, Brian
W; Potts, James
E; Stephenson,
Elizabeth A
BC Children’s
Hospital
A randomized, double-blind,
multi-center study of antiarrhythmic medications in the treatment
of infants with supraventricular
tachycardia (SAMIS trial).
Arrhythmia, supraventricular
tachycardia, treatment, clinical
trial, infants.
20062010
$111,420
$334,188
II, III,
IV
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
84
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Steinbrecher, Urs P
University of
British Columbia
Activation of macrophage growth
and survival pathways by oxidized
LDL.
Tibbits, Glen F;
Paetzel, Mark W
Simon Fraser
University
Regulation of cardiac myofilament
sensitivity to calcium.
van Breemen,
Cornelis ; Laher,
Ismail
St. Paul’s Hospital
Walley, Keith R;
Murkin, John M;
Sandford, Andrew
J; Russell, James
A; Lichtenstein,
Samuel V
06-07 $
Total $*
Theme
Thème
20042009
$141,658
$703,402
I
Troponin C, design of calcium
sensitizing drugs, cardiac contractility, familial hypertrophic
cardiomyopathy.
20062009
$152,150
$456,378
I
Cellular mechanisms of vascular
dysfunction in human diabetes.
Human vessels, diabetes,
vasomotion, calcium imaging.
20042007
$103,740
$307,693
I
University of
British Columbia
Genetic determinants of
cognitive dysfunction following
cardiopulmonary bypass.
Cardiopulmonary bypass,
genes, polymorphisms,
cognitive dysfunction.
20042007
$180,000
$543,880
III
Wang, Yu Tian
University of
British Columbia
Investigation into the molecular
mechanisms mediating
excitotoxicity - developing novel
post-stroke therapies.
NMDA receptor, excitotoxicity,
stroke, AMPA receptor,
apoptosis.
20062011
$121,340
$606,664
I
Wellington, Cheryl L
University of
British Columbia
ABCG1, HDL metabolism, and
atherosclerosis.
ABCG1, cholesterol efflux,
atherosclerosis, transgenic,
lipid transport.
20052008
$115,980
$337,961
I
Wright, Joanne L
University of
British Columbia
Mechanisms of cigarette
smoke-induced pulmonary
hypertension.
Endothelin, eNOS, vascular
physiology, COPD, cigarette
smoke, remodeling.
20062007
$42,384
$42,384
I
Yang, Decheng
St. Paul’s Hospital
Mechanisms of apoptotic cell
death induced by a newly isolated
mBNip21 gene in coxsackievirus
B3-infected mouse heart.
Apoptosis, virus, host gene
response, signal transduction,
myocarditis.
20042007
$17,000
$50,422
I
Yang, Decheng
St. Paul’s Hospital
Roles of viral protease genes and
the mouse NAT1 gene.
Myocarditis, coxsackievirus,
death pathways, NAT1,
apoptosis.
20042007
$59,659
$176,949
I
Zehr, E Paul
University of
Victoria
Utilization of spinal circuitry and
cutaneous feedback for recovery
of walking after stroke.
Stroke, reflex, feedback,
walking, central patterning,
cutaneous.
20052009
$120,000
$475,848
I, II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
85
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Alberta/Northwest Territories/Nunavut | Alberta / Territoires du Nord-Ouest / Nunavut
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Anderson, Todd J
Foothills Hospital
HDL modulation and endothelial
function.
Endothelium, cholesterol,
HDL, atherosclerosis,
vascular biology.
20052008
$90,000
$180,000
II
Barber, Philip A
University of
Calgary
The characterisation of the
neuroinflammatory endothelial
response to ischemia/reperfusion
by magnetic resonance molecular
imaging (MRMI).
Cerebral ischemia,
neuroinflammation,
magnetic resonance
molecular imaging.
20042007
$49,000
$147,000
I
Beaulieu, Christian
University of
Alberta
Advanced MRI methods for brain
evaluation in acute stroke.
Magnetic resonance
imaging, acute stroke,
20062009
$52,000
$52,000
I, II
Braun, Andrew P
University of
Calgary
Integrin signalling and regulation of Vascular contractility,
large conductance, Ca-activated K+ integrin signalling, Cachannels in smooth muscle.
activated K+ channels,
tyrosine phosphorylation.
20042007
$49,000
$147,000
I
Brindley, David N
University of
Alberta
Regulation of smooth muscle
cell migration and division by
sphingosine 1-phosphate.
Angiogenesis, atherosclerosis, EDG receptors, platelet
derived growth factor,
sphingosine-1-phosphate.
20052008
$49,000
$98,000
I
Casey, Joseph R
University of
Alberta
Cl / HCO3 Exchangers in cardiac
ischemia and hypertrophy.
Chloride / bicarbonate
exchange, pH regulation,
hypertrophy, ischemia,
bicarbonate transport.
20052008
$52,000
$104,000
I
Chen, SR Wayne
University of
Calgary
Structure and function of the trout
cardiac ryanodine receptor: insight
into the molecular basis of
spontaneous Ca2+ release.
Cardiac arrhythmia, EC
coupling, sarcoplasmic
reticulum, Ca2+ release,
ryanodine receptor, single
channel recordings, cDNA
cloning.
20052008
$57,000
$114,000
I
Cheung, Po-Yin
University of
Alberta
The use of supplemental oxygen
in the resuscitation of asphyxiated
newborns.
Newborn, hypoxiareoxygenation, resuscitation,
hemodynamics, swine.
20042007
$52,000
$156,000
I
Childs, Sarah J
University of
Calgary
Identifying genetic pathways for the Angiogenesis, development,
susceptibility to hemorrhage during genetics, zebrafish,
early development.
hemorrhage.
20052008
$57,000
$114,000
I
Cole, William C;
Plane, Frances
University of
Calgary
Role of endothelial small
conductance Ca2+ activated K+
channels in delayed cerebral
vasospasm in a rat model of
subarachnoid hemorrhagic stroke.
20062009
$57,000
$57,000
I
$ cumulatif
reçu en 2007
diffusion, perfusion, sodium.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
86
Cerebral vasospasm, stroke,
endothelium, SKCa channels,
nitric oxide.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Demchuk, Andrew
M; Green, Theresa
L; Eliasziw, Michael
Foothills Medical
Centre
Evaluation of magnetic resonance
TIA, acute stroke, arterial
imaging as a potential surroocclusion, MRI, prognosis.
gate endpoint for future stroke.
Intervention trials when compared
to clinical outcomes in nondisabling
minor stroke and TIA (VISION-2).
20062009
$49,000
$49,000
I, II, III,
IV
Duff, Henry J
University of
Calgary
Genetic and environmental calcium
interactions modulate the cellular
LQT2 phenotype.
Cellular calcium, ryanodine
receptor, restitution of
repolarization, postextrasystolic potentiation,
T wave alternan.
20062009
$49,000
$49,000
I
Dyck, Jason RB
University of
Alberta
The effects of the PRKAG2
mutations on cardiac energy
AMPK, glycogen, cardiac
energy metabolism,
20052008
$57,000
$114,000
I
metabolism.
PRKAG2 mutations, WolffParkinson-White syndrome.
$ cumulatif
reçu en 2007
El-Kadi, Ayman O
University of
Alberta
The role of cytochrome P450 family
1 enzymes in the development of
cardiac hypertrophy.
Arachidonic acids, cardiac
hypertrophy, cytochrome
P450, signaling pathways,
oxidative stress.
20062009
$49,000
$49,000
I
Francis, Gordon A
University of
Alberta
Apolipoprotein-mediated lipid
efflux from arterial smooth muscle
cells.
Apolipoproteins, smooth
muscle cells, atherosclerosis,
cholesterol, HDL.
20042007
$57,000
$171,000
I
Frayne, Richard ;
Mahallati, Houman
Foothills Hospital
Large Field of View (LFOV)
Magnetic Resonance Angiography
(MRA) for rapid assessment of
Peripheral Arterial Disease (PAD).
Magnetic Resonance
Angiography (MRA),
Peripheral Arterial Disease
(PAD), vascular imaging,
atherosclerosis.
20042007
$57,000
$171,000
I
French, Robert J
University of
Calgary
Molecular bases of sodium channel
isoform-specific drug targeting.
Sodium channels,
conotoxins, channel block,
drug specificity, antiarrhythmic / anticonvulsive / local
anaesthetic.
20062009
$57,000
$57,000
I
Goodyear, Bradley
G
University of
Calgary
Functional magnetic resonance
imaging techniques to assess
recovery after ischemic stroke.
Functional magnetic
resonance imaging, ischemic
stroke, perfusion, functional
recovery, functional
reorganization.
20042007
$49,000
$147,000
I
Haykowsky, Mark J;
Tymchak, Wayne J
University of
Alberta
Effects of exercise training on peak
aerobic power, cardiovascular and
musculoskeletal performance and
quality of life in cardiac transplant
recipients.
Cardiac rehabilitation,
exercise testing &
prescription, cardiovascular
skeletal muscle function,
cardiac transplantation.
20042007
$49,000
$147,000
II
Hill, Michael D
University of
Calgary
Tissue window in stroke
thrombolysis -2.
Stroke thrombolysis, brain
imaging, clinical trial.
20062009
$57,000
$57,000
II, IV
Jacobs-Kaufman,
Susan E
University of
Alberta
Long-term effect of pregnancy on
neural control of the cardiovascular
system.
Pregnancy, parity,
sympathetic.
20062009
$49,000
$49,000
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
87
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Jhamandas, Jack H
University of
Alberta
Role of RFamide peptides in central Neuropeptide FF, prolactincardiovascular and neuroendocrine releasing peptide,
regulation.
hypothalamus, patch clamp,
immunocytochemistry.
20042007
$57,000
$171,000
I
Jugdutt, Bodh I
University of
Alberta
Vasopeptidase inhibition and AT1
receptor blockade in remodeling
after reperfused MI.
20052008
$49,000
$98,000
I, II
Kargacin, Gary J
University of
Calgary
Regulation of compensatory ion
channels in cardiac and smooth
muscle sarcoplasmic reticulum.
Sarcoplasmic reticulum,
compensatory charge
movement, potassium
channels, chloride channels.
20062009
$52,000
$52,000
I
Kargacin, Margaret E University of
Calgary
Phospholamban and regulation of
SR calcium.
Calcium, cardiac, sarcoplasmic reticulum, Ca-ATPase,
phospholamban.
20062009
$49,000
$49,000
I
Kavanagh,
Katherine M
University of
Calgary
The electrophysiological properties Arrhythmias, electrophysioof the myocardial substrate in health logy, cardiac mapping, heart
and disease.
failure, myocardial substrate.
20042007
$49,000
$147,000
I
King, Kathryn M;
Ghali, William;
Campbell, Tavis ;
Verhoef, Marja
University of
Calgary
Making decisions about using
chelation therapy.
20062008
$37,400
$37,400
II, III,
IV
Krukoff, Teresa L
University of
Alberta
Adrenomedullin and regulation of
autonomic function.
Adrenomedullin,
paraventricular nucleus,
autonomic, brain, blood
pressure, baroreflex, nitric
oxide, calcium.
20062009
$52,000
$52,000
I, II
Kubes, Paul
University of
Calgary
Role of LSP-1 as a gatekeeper of
the blood brain barrier to neutrophils.
Adhesion, inflammation,
microvasculatures, selectins,
integrin.
20062009
$52,000
$52,000
I
Lehner, Richard
University of
Alberta
Triacylglycerol synthesis.
Triacylglycerol,
acyltransferase, obesity,
VLDL, atherosclerosis
20042007
$54,000
$159,500
I
Light, Peter E
University of
Alberta
Wolff-Parkinson-White syndrome,
AMP-activated protein kinase
mutations and cardiac excitability.
AMPK, Wolff-ParkinsonWhite syndrome,
arrhythmias, sodium
hannels, patch clamp.
20052008
$31,545
$63,090
I
Lopaschuk, Gary D
University of
Alberta
Cardiac lipotoxicity in obesity and
diabetes.
Obesity, energy metabolism,
fatty acids, cardiotoxicity.
20062009
$57,000
$57,000
I
Lytton, Jonathan
University of
Calgary
Molecular regulation of SERCA
calcium pumps.
Molecular biology, calcium
signaling, structure-function,
ion transport.
20042007
$52,000
$156,000
I
MacDonald, Justin A
University of
Calgary
Characterization of CHASM
involvement in cGMP-evoked
calcium desensitization in vascular
smooth muscle.
Calcium desensitization,
smooth muscle tone, nitric
oxide, cGMP-dependent
protein kinase, signal
transduction.
20042007
$52,000
$156,000
I
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
88
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Mitchell, J Ross R
Foothills Hospital
Advanced medical image
processing and analysis to identify
salvageable tissue in acute
ischemic stroke.
Morrish, Donald W
University of
Alberta
Endothelial progenitor cells in
pregnancy and preeclampsia.
Murray, Allan G
University of
Alberta Hospital
Nygren, Anders ;
Vigmond, Edward J;
Leon, L Joshua
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
20042007
$49,000
$147,000
I
Preeclampsia, pregnancy,
endothelial progenitor cells.
20062009
$49,000
$49,000
I, II
Remodelling of endothelial
cells-matrix anchors.
Endothelium, vascular,
cytoskeleton, cell migration.
20062009
$49,000
$49,000
I, II
University of
Calgary
Computational and experimental
investigation of the effects of spatial
heterogeneity of refractoriness on
inducibility and maintenance of
atrial fibrillation in the mouse atria.
Atrial fibrillation, mouse
atrium, computer models,
optical mapping, dispersion
of refractoriness.
20052007
$49,000
$98,000
I
Patel, Kamala
D; Colarusso,
Giuseppina T
University of
Calgary
Mechanotransduction in early
atherosclerosis.
Atherosclerosis,
mechanotransduction,
VCAM-1, shear stress,
adhesion.
20042007
$57,000
$171,000
I
Poulin, Marc J;
Hanly, Patrick JV
University of
Calgary
Regulation of cerebral blood flow
in obstructive sleep apnea: role of
nitric oxide.
Cerebral blood flow, hypoxia
and hypercapnia, obstructive
sleep apnea, nitric oxide,
doppler ultrasound.
20062009
$65,554
$65,554
I, II, III,
IV
Proctor, Spencer D
University of
Alberta
Mechanisms of trapping
apoB48-remnant lipoproteins in
arterial tissue by proteoglycans
during atherogenesis and
insulin-resistance.
Atherogenesis,
chylomicrons,
proteoglycans, insulinresistance, adiponectin.
20062009
$49,000
$49,000
I
Saucier, Deborah M. University of
Lethbridge
Age and environmental effects of
hypoxic-ischemic brain damage.
Aging, stroke, hypoxiaischemic, enrichment,
recovery.
20042007
$58,500
$174,700
I
Severson, David L
University of
Calgary
Mechanisms of diabetic
cardiomyopathy - cardiac efficiency
in hearts from diabetic mice.
Cardiac function, diabetes,
diabetic cardiomyopathy.
20062009
$49,000
$49,000
I
Sheldon, Robert S
University of
Calgary
Statin induced regression of
cardiomyopathy trial (SIRCAT).
Hypertrophic cardiomyopathy, statins, cardiac MRI,
clinical study, arrhythmia.
20062009
$89,260
$89,260
I, II
Shimoni, Yakhin
University of
Calgary
Chamber-specific modulation of
cardiac potassium currents.
Diabetes, potassium
currents, autocrine, natriuretic
peptides, angiotensin.
20052008
$49,000
$98,000
I
Shuaib, Ashfaq ;
Wang, Chen Xu
University of
Alberta
The role of endothelial dysfunction
in the pathophysiology of
cerebrovascular disease.
Apoptosis, endothelium,
injury, stroke, vascular.
20052008
$86,000
$176,000
I, II
Simmonds, Andrew
J; Bell, John B
University of
Alberta
Identification of co-factors for
the TEF and MEF-2 family of
transcription factors required for
establishment and maintenance
of heart progenitor cell fate.
Transcription, genetic
disease loci, heart
development, drosophila.
20052008
$46,600
$98,600
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
89
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Smith, Francine G
University of
Calgary
The renin-angiotensin system
during ontogeny.
Angiotensin II, newborn,
kidney, blood pressure,
perinatal.
20052008
$49,000
$98,000
I
Smith, Peter A;
Dryden, William F
University of
Alberta
Nicotinic acetylcholine receptors in
the cardiovascular system.
Hypertension, cigarettes,
ganglionic transmission,
microvasculature, coronary
endothelial cells.
20052008
$49,000
$98,000
I
Sykes, Brian D
University of
Alberta
Structure of cardiac troponin in
complex with cardiotonic drugs.
Structure, troponin C,
troponin I, calcium binding,
cardiotonic drugs, NMR.
20052008
$57,000
$114,000
I
ter Keurs, Henk EDJ
University of
Calgary
The velocity of cardiac muscle
shortening.
Cardiac muscle, congestive
heart failure, excitation
contraction coupling, high
speed confocal micro,
ischemic heart disease,
sarcomere mechanics.
20062009
$57,000
$57,000
I
Thebaud, Bernard
University of
Alberta
The role of phosphodiesterases
and Ca++ sensitive K+ channels in
pulmonary vascular abnormalities
associated with congenital
diaphragmatic hernia.
Pulmonary hypertension
of the newborn,
phosphodiesterase,
potassium channels, smooth
muscle cell, lung growth,
vasoreactivity.
20042007
$34,600
$148,600
I
Tse, Amy Me-War
University of
Alberta
Regulation of chemotransduction in Respiration, neuron-glial
carotid bodies.
interactions, oxygen sensing,
secretion, calcium.
20062009
$52,000
$52,000
I
Tsuyuki, Ross T;
McAlister, Finlay A;
Johnson, Jeffrey A;
Jones, Charlotte A;
King, Kathryn M;
McLean, Donna L
University of
Alberta
Improving hypertension
management in patients with
diabetes in the community.
Adherence, hypertension,
diabetes, community,
management.
20052007
$88,000
$163,000
III, IV
Tuor, Ursula
University of
Calgary
Diagnosis and mechanisms of
hypoxic-ischemic injury in cerebral
white matter.
Magnetic resonance
imaging, immunohistochemistry, cerebral hypoxia
ischemia, white matter injury,
hypothermia.
20052008
$49,000
$98,000
I
Vance, Jean Eaton
University of
Alberta
Lipoprotein secretion and
phosphatidylserine metabolism.
Phosphatidylserine,
phospholipid, VLDL
secretion, apo B,
phosphatidylethanolamine.
20042007
$49,000
$147,000
I
Vigmond, Edward J;
Vinet, Alain
University of
Calgary
Localization of neural modulation of
atrial excitation and repolarization
and the arrhythmogenic
consequences.
Electrograms, atria, cardiac
autonomic nervous system,
arrhythmogenesis, computer
modeling.
20062009
$45,200
$45,200
I
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
90
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Walsh, Michael P
University of
Calgary
Vascular smooth muscle S100A11
calcium-binding protein.
Vascular smooth muscle,
S100 calcium-binding
proteins, contractility,
membrane-cytoskeleton
interaction, annexins.
20042007
$57,000
$171,000
I
Welsh, Donald G;
Vigmond, Edward J
University of
Calgary
Cell-to-cell communication in the
resistance vasculature.
Peripheral circulation,
computer modeling,
electrophysiology, vascular
smooth muscle, cell-to-cell
communication.
20042007
$49,000
$147,000
I
Winston, Brent W
University of
Calgary
Induction of factor B and/or
activation of the alternative
complement cascade contribute to
20052008
$52,000
$104,000
I, II
20042007
$57,000
$171,000
I
$ cumulatif
reçu en 2007
cardiac dysfunction, multiple organ
dysfunction and shock in sepsis.
Wong, Norman CW
University of
Calgary
Augmenting apolipoprotein AI
expression: effects on reverse
cholesterol transport and
atherosclerosis.
Young, Howard S
University of
Alberta
Molecular insights into heart
disease - structure, function and
regulation of SERCA2a.
Heart disease, muscle,
membrane, regulation,
sarcoplasmic reticulum.
20062009
$57,000
$57,000
I
Zamponi, Gerald W
University of
Calgary
Regulation of calcium channel beta
subunit function by Rem2.
Calcium channels, Rem2,
immunocytochemistry,
electophysiology, imaging.
20052008
$57,000
$114,000
I
06-07 $
Cumulative $
Theme
to 2007
Thème
Saskatchewan | Saskatchewan
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Hiebert, Linda M
University of
Saskatchewan
Oral heparins.
Lee, Paul M;
Prasad, Kailash
University of
Saskatchewan
Hyperhomocysteinemia and
hypertension.
Meng, Qing H; Wu,
Lingyun; Wang, Rui
University of
Saskatchewan
Protective role of hydrogen
sulfide in atherosclerosis.
Ndisang, Joseph
Fomusi
University of
Saskatchewan
Interaction of the heme
oxygenase pathway with
renin-angiotensin system in
diabetes.
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
$ cumulatif
reçu en 2007
II: Clinical
II : Clinique
Heparin, oral absorption,
endothelium, thrombosis
models, pharmacokinetics.
20052008
$58,500
$118,500
I
20042007
$40,000
$141,000
I
Cystathionine gamma-lyase
(CSE), hydrogen sulfide (H2S),
homocyteine, balloon injury,
atherosclerosis.
20052008
$58,500
$118,500
I
Diabetes, hypertension,
angiotensin, heme oxygenase
inducers, carbon monoxide.
20062009
$58,500
$58,500
I, II,
III, IV
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
91
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Paterson, Phyllis G
University of
Saskatchewan
Protein-energy malnutrition as
a determinant of brain injury in
stroke.
Nutrition, stroke, glutathione,
protein-energy malnutrition,
global ischemia.
20042007
$58,500
$88,328
I
Prasad, Kailash
University of
Saskatchewan
Flax lignan complex in the
progression and regression of
hypercholesterolemic
atherosclerosis and mechanisms.
Atherosclerosis, endothelial
cell function, lipids, oxygen
radicals, regression.
20062009
$58,500
$58,500
I
Sharma, Rajendra K
University of
Saskatchewan
Calmodulin regulated systems in
heart.
Ca2+, calmodulin, calmodulinbinding proteins, Ca2+ activated proteases,
phosphodiesterases, cardiac
metabolism.
20062009
$67,000
$67,000
I
Walz, Wolfgang
University of
Saskatchewan
The gliotic response in focal
ischemia.
Astrocytes, reactive gliosis,
focal ischemia, patch clamp,
immunocytochemistry.
20052008
$58,500
$118,500
I
Wu, Lingyun
University of
Saskatchewan
Methylglyoxal, a causative factor
for hypertension development
- MG induced vascular damage
and the underlying mechanisms.
Methylglyoxal, advanced
glycated endproducts (AGEs),
vascular function, proliferation,
hypertension.
20052008
$65,000
$140,000
I
Zhang, Xia
University of
Saskatchewan
Post stroke treatment with
cannabinoids for promoting
neural regeration.
Ischemia, marijuana,
neurogenesis, hippocampus,
functional recovery.
20062009
$58,500
$58,500
I
$ cumulatif
reçu en 2007
Manitoba | Manitoba
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Bose, Ratna
University of
Manitoba
Characterization of the sodium/
calcium exchanger in human
platelets and its role in diabetes.
Platelets, calcium, sodium,
diabetes.
20062009
$35,000
$35,000
I, II
Czubryt, Michael P
St. Boniface G.H.
Research Centre
The role of scleraxis in the
regulation of cardiac collagen
synthesis.
Fibrosis, myofibroblasts,
gene expression, collagen,
transciption.
20062009
$33,000
$33,000
I
Del Bigio, Marc R
University of
Manitoba
Periventricular hemorrhage in
immature brain.
Stroke, cerebral palsy,
perinatal, brain hemorrhage.
20062009
$39,000
$39,000
I
Dhalla, Naranjan S
St. Boniface G.H.
Research Centre
Studies on the biochemical basis
of heart function: adrenergic
mechanisms in failing hearts.
Congestive heart failure,
beta-adrenoceptors,
G-proteins, adenylyl cyclase,
signal transduction.
20042007
$50,500
$151,000
I
Dixon, Ian
St. Boniface G.H.
Research Centre
Inhibition of the Smad signal in
post-MI heart failure.
Myocardial infarction, gene
expression, cardiac fibrosis,
collagen, hypertrophy and
heart failure, Smad.
20042007
$45,300
$127,400
I
Hatch, Grant M
University of
Manitoba
Regulation of cardiolipin
biosynthesis.
Heart, cardiolipin,
phospholipid, metabolism,
eukaryotic cells.
20042007
$35,000
$98,000
I
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
92
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Israels, Sarah J
Manitoba Institute
of Cell Biology
The roles of CD63 and PI 4-kinase
in platelet integrin signaling.
Jones, Peter JH
University of
Manitoba
Satiety and energy expenditure
enhancement actions of
diacylglycerol oil.
Kardami, Elissavet
University of
Manitoba
Connexin43 and cardiac myocyte
proliferation.
Kirshenbaum, Lorrie
A
St. Boniface G.H.
Research Centre
Mechanisms of p53 mediated
apoptosis in the heart.
Light, Robert B;
Jacobs, Hans K
St. Boniface G.H.
Research Centre
Left ventricular performance in
gram negative sepsis.
McNicol, Archibald
University of
Manitoba
Mesaeli, Nasrin
Moghadasian,
Mohammed Hassan
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
20052007
$40,000
$75,000
I
Diacylglycerol oil, obesity,
weight loss, satiety, magnetic
resonance imaging.
20062009
$34,000
$34,000 I, II, III,
IV
Connexin43, cardiomyocytes,
cell cycle inhibition, structurefunction, heart regeneration.
20052008
$50,600
$96,200
I
20042007
$47,400
$125,200
I
Myocardial depression in
sepsis, septic shock,
myocardial depressant factor.
20042007
$44,400
$122,200
I
MAP kinase pathways and
platelets.
Platelets, signaling, kinases,
GEMs.
20052008
$38,000
$73,000
I
St. Boniface G.H.
Research Centre
Regulation of cell proliferation by
calreticulin.
Vascular function, calcium
regulation, gene regulation.
20062009
$38,000
$38,000
I
University of
Manitoba
Heart transplantation, apo
Mechanisms of atherogenesis in
apolipoprotein E-KO mice: studies E-KO mice, lipoprotein,
of the role of plasma lipoproteins, probucol, atherosclerosis.
vascular apolipoprotein E, dietary
cholesterol and probucol in a
mouse heart transplant model.
20052008
$39,000
$77,000
I
Netticadan, Thomas St. Boniface G.H.
J
Research Centre
Mechanisms underlying
contractile dysfunction in heart
failure due to volume overload.
Sarcoplasmic reticulum,
volume overload hypertrophy,
heart failure.
20042007
$33,000
$94,000
I
O, Karmin
St. Boniface G.H.
Research Centre
Effect of folic acid on
hyperhomocysteinemia.
Hyperhomocysteinemia,
atherosclerosis, folic acid,
chemokines, oxidative stress.
20062009
$36,000
$36,000
I
Pierce, Grant N
St. Boniface G.H.
Research Centre
Involvement of Na/Ca exchange in Heart, Na/Ca exchange,
ischemia/reperfusion (I/R) injury.
cardiomyocytes, adenovirus.
20042007
$48,500
$48,500
I
Schlichter, Lyanne
C; Peeling, James ;
Corbett, Dale R
Toronto Western
Research Institute
Targeting K channels to control
inflammation in stroke.
Intracerebral hemorrhage,
focal ischemia, retinal ischemia,
optic nerve transection, potassium channels, CNS inflammation, immune-cell activation.
20052008
$49,000
$92,000
I
University of
Manitoba
Regulation by stress-associated
scaffold protein in ischemia/
reperfusion.
SAP kinase, scaffold,
regulation, ischemia/
reperfusion, inhibitor.
20062009
$32,000
$32,000
I
Wigle, Jeffrey TN
St. Boniface G.H.
Research Centre
Mox mediated differentiation of
vascular smooth muscle cells and
cardiomyocytes in embryonic
development and disease.
Cell-cycle, atherosclerosis,
homeobox, differentiation,
migration.
20042007
$37,000
$100,000
I
Zhang, Shetuan
University of
Manitoba
Molecular mechanisms of
drug-induced long QT syndrome
and sudden cardiac death.
Myocardium, emergency
cardiac care, electrophysiology,
molecular biological techniques, cardiac dysrrhythmias.
20062009
$36,000
$36,000
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
93
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Ontario | Ontario
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Adams, Michael A;
Heaton, Jeremy PW
Queen’s University
Antihypertensive treatment
strategies in the management
of sexual dysfunction.
Hypertension, blood pressure,
sexual dysfunction, antihypertensives, vascular structure,
endothelial function.
20052008
$99,010
$330,003
I
Adeli, Khosrow
Hospital for Sick
Children
Molecular mechanisms of
apolipoprotein B degradation.
Apolipoprotein B,
degradation, hepatocytes,
proteasome, ER60.
20052009
$113,285
$457,758
I
Adeli, Khosrow
Hospital for Sick
Children
Molecular mechanisms of VLDL
overproduction in insulin
resistant states.
Apolipoprotein B, lipoprotein,
liver, insulin resistance, hamster,
insulin signaling, diabetes.
20042007
$100,798
$296,503
I
Anand, Sonia S;
Bosch, Jacqueline
J; Gaudet, Daniel;
Gerstein, Hertzel C;
Keavney, Bernard
D; Merchant, Anwar
T; Pogue, Janice M;
Yusuf, Salim
McMaster
University
EpiDREAM - A prospective
cohort study to determine
environmental and genetic
determinants of metabolic
syndrome related factors.
Metabolic syndrome, cohort
study, gene-environment
interactions.
20062009
$165,072
$475,656
IV
Ananthanarayanan,
Vettai S
McMaster
University
Structural aspects of collagen
biosynthesis: studies on Hsp47.
Collagen, Hsp47, structurefunction correlation, protein
structure, spectroscopy.
20042007
$67,741
$199,369
I
Andrew, R David
Queen’s University
Imaging and preventing early
stroke damage in intact
mammalian neurons.
2-photon, anoxic
depolarization, dendrite,
swelling, imaging.
20062009
$72,613
$220,406
I, II
Austin, Richard C;
Chan, Anthony
McMaster
University
Inhibition of tissue factor
procoagulant activity by GRP78
and its role in atherothrombotic
disease.
GRP78, tissue factor, thrombin
generation, endoplasmic
reticulum stress,
thromboembolic disease.
20042007
$81,737
$240,981
I
Backx, Peter H
University of
Toronto
Role of inward rectifier K+ and
HCN channels in heart.
Transgenics, electrophysiology,
heart disease, ion channels,
arrhythmias.
20052008
$126,393
$379,259
I
Ball, Eric H
University of
Western Ontario
Metavinculin interactions in
hereditary cardiomyopathy.
Intercalated disc, protein
interactions, protein structure,
adherens junction,
cytoskeleton.
20052007
$61,853
$123,706
I
Bartha, Robert;
Lee, Ting-Yim;
Xenocostas,
Anargyros
Robarts Research
Institute
New metabolic imaging
approaches to assess brain
tissue viability.
1H MRS, high resolution
metabolic MR imaging, acute
cerebral ischemia, metabolite
quantification, molecular
penumbra.
20062009
$81,134
$251,519
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
94
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Bates, Shannon M;
Ginsberg, Jeffrey
S; Kearon, Clive;
Julian, Jim A;
Douketis, James D
McMaster
University
Diagnosis of suspected
pulmonary embolism with
D-dimer.
Pulmonary embolism,
diagnosis, D-dimer.
20052007
$66,591
$181,578
II
Beanlands, Rob SB;
Haddad, Haissam;
Burwash, Ian G;
Floras, John S;
DaSilva, Jean N; de
Kemp, Robert A;
Leech, Judith A
University of
Ottawa Heart
Institute
Effects of continuous positive
airway pressure therapy on
myocardial energetics and
sympathetic nerve function in
patients with heart failure and
obstructive sleep apnea.
Heart failure, sleep apnea,
oxidative metabolism, cardiac
efficiency, sympathetic nerve
function, PEP.
20052008
$120,972
$362,941
II
Benazon, Nili R;
Arthur, Heather M;
Kodis, Jennifer;
Toner, Brenda B;
Blanchard, Chris M
Centre for
Addiction and
Mental Health
Correlates of women’s
compliance with exercise
prescriptions during and
following cardiac rehabilitation.
Cardiology, health-related
behaviours, exercise, women,
psychosocial.
20052007
$54,109
$106,805
II
Bendeck, Michelle
P
University of
Toronto
The effect of doxycycline on
smooth muscle cell response
to injury.
Vascular biology,
atherosclerosis/restenosis,
matrix metalloproteinase,
extracellular matrix.
20042007
$69,370
$204,114
I
Boffa, Michael B
Queen’s University
The TAFI pathway in
thrombolysis: regulation of
TAFI activation and role of
the platelet pool of TAFI.
TAFI, fibrinolysis, thrombolysis,
platelets, transgenic mice.
20062009
$86,839
$289,600
I
Bonen, Arend
University of
Guelph
Regulation of fatty acid
transport in the heart.
Fatty acid transporters,
transport, metabolism, heart,
cardiac myocytes.
20062011
$96,323
$488,296
I
Boughner, Derek
R; Rogers, Kem
A; Rutt, Brian K;
Drangova, Maria
University of
Western Ontario
Aortic sclerosis in an animal
model: progression, regression
and evaluation.
20052007
$73,539
$150,689
I, II
Boughner, Derek
R; Rogers, Kem A;
Lacfield, James
University of
Western Ontario
A tissue engineering approach
to bioprosthetic heart valve
design.
Tissue engineering, aortic
valve, biomechanics,
ultrasound imaging, valvular
interstitial cells.
20062009
$107,038
$307,457
I
Brouwer, Brenda;
Malouin, Francine;
Bagg, Stephen
Queen’s University
Does mental practice promote
corticol reorganization and
improved hand function in
acute stroke? A prospective
intervention study.
Rehabilitation, stroke,
transcranial magnetic
stimulation, imagery, function.
20042007
$45,842
$152,831
I, II
Brown, Arthur
Robarts Research
Institute
EphA3 receptor signaling in
heart development.
Heart development, Eph
receptors, mouse genetics,
knock-outs, cell signaling.
20022007
$101,478
$488,236
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
95
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Bruneau, Benoit G
Hospital for Sick
Children
Roles of T-box genes in
cardiovascular research.
Transgenic mice, congenital
heart defects, transcription
factors, gene expression,
cardiovascular development.
20042007
$100,248
$300,744
I
Capone, John
P; Rachubinski,
Richard A
McMaster
University
Function and mechanisms
of action of peroxisome
proliferator-activated
receptors.
Nuclear hormone receptors,
peroxisome proliferators, gene
expression, transcription
factors, lipid metabolism.
20032008
$145,042
$716,322
I
Cepinskas,
Gediminas
Lawson Research
Institute
The mechanisms of neutrophilinduced negative feedback
regulation of transcription factor NFkB in endothelial cells
during inflammation: role of
PECAM-1 (CD31).
Inflammation/sepsis, adhesion
molecules, cell signaling,
endothelium, leukocytes.
20052007
$49,540
$99,080
I
Chakrabarti,
Subrata; Karmazyn,
Morris
University of
Western Ontario
Vasoactive and cardioactive
factors in diabetic heart
disease.
Cardiomyopathy, diabetes,
hypertrophy, gene
transcription, PARP.
20062008
$75,550
$148,684
I
Chan, Anthony KC
McMaster
University
Investigation into the
interactions of covalent
antithrombin-heparin (ATH)
complex with surface-bound
coagulant factors.
Antithrombin, heparin,
anticoagulant, fibrin,
endothelial.
20042007
$72,690
$213,824
I
Chan, Anthony KC
McMaster
University
The influence of age on the
protein C pathway during
chemotherapy treatment.
Children, thromboembolism,
(anti)coagulation, protein C,
chemotherapy.
20052007
$83,582
$162,716
I
Chan, Christopher
T; Verma, Subodh
Toronto General
Hospital
Impact of uremia on
endothelial progenitor cells.
Renal failure, endothelial
function, arterial compliance,
left ventricular hypertrophy,
endothelial progenitor cells.
20052007
$67,905
$134,842
I, II
Chauhan, Vijay S;
Picton, Peter
Toronto General
Hospital
Characterizing ventricular
repolarization alternans in
human cardiomyopathy.
Repolarization, tachyarrhythmia,
cardiomyopathy, ventricle,
human.
20062007
$35,000
$35,000
II
Choong, Karen;
Bohn, Desmond;
Hutchison, James;
Menon, Kusum;
Gaboury, Isabelle
McMaster
University
A study of the efficacy of
vasopressin in pediatric
vasodilatory shock.
Vasodilatory shock,
vasopressin, pediatrics,
clinical trial.
20062007
$61,623
$61,623
II
Ciriello, John
University of
Western Ontario
Role of sex steroids in central
regulation of arterial pressure.
Ventral medulla, aterial
pressure, vagus, hypertension,
female, Gaba, nitric oxide.
20062007
$35,000
$35,000
I
Clarke, Bryan J
McMaster
Factor VII as an inhibitor of
coagulation, sepsis and cancer.
Coagulation, clotting factor
VII, tissue factor, thrombosis,
coagulation inhibitors.
20062008
$82,723
$167,101
I
University
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
96
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Coles, John G;
Hannigan, Gregory
E
Hospital for Sick
Children
Integrin-linked kinase (ILK)
induces adaptive remodeling
in dilated cardiac failure.
Cardiac hypertrophy, signal
transduction, transgenesis,
heart failure, congenital heart
disease.
20052007
$86,440
$171,975
I, II
Coles, John G;
Hannigan, Gregory
E
Hospital for Sick
Children
The regulation of cellular
signaling in cardiac progenitor
cells.
Cardiac stem cells, cardiomyogenesis, cell signaling, cardiac
surgery, regenerative medicine.
20062008
$76,039
$153,599
I
Connelly, Philip W
St. Michael’s
Hospital
Comparative studies of
paraoxonase 1 and
paraoxonase 3.
Lactones, paraoxonase,
lipoproteins, atherosclerosis,
hydroxy fatty acids.
20052008
$59,826
$179,501
I
Connelly, Philip W;
Stewart, Duncan J
St. Michael’s
Hospital
Molecular mechanisms for
oxidation of high density
lipoproteins.
Nitric oxide, high density
lipoproteins, inflammation,
oxidation, vascular.
20062008
$96,529
$195,994
I, II
Copeland, John W
University of
Ottawa
Role of formin proteins in shear
stress-induced cytoskeletal
remodeling in endothelial cells.
Actin cytoskeleton, shear
stress, atherosclerosis, formin,
adherens junctions.
20062008
$87,865
$165,875
I
Cote, Graham P
Queen’s University
Formation of podosome-like
structures in vascular smooth
muscle cell by PAK.
Smooth muscle cell,
biochemistry.
20042007
$79,353
$233,678
I
Courtman, David
W; Stewart, Duncan
J
St. Michael’s
Hospital
Arterial remodeling: regulation
of aneurysm growth.
Aneurysm, extracellular matrix,
smooth muscle, angiotensin,
transcription factor.
20052007
$69,360
$137,360
I
Cregan, Sean P
Robarts Research
Institute
p53 signaling in oxidative
damage induced neuronal
apoptosis.
Stroke, p53, apoptosis,
oxidative damage, neuronal
injury.
20062008
$72,800
$147,056
I
Crowther, Mark
A; Lim, Wendy;
Clase, Catherine M;
Douketis, James D;
Rabbat, Christian G
St. Joseph’s
Hospital
Tinzaparin for treatment of
venous thromboembolism in
renal insufficiency: a pilot study.
Low molecular weight heparin,
tinzaparin, renal insufficiency,
venous thromboembolism,
safety.
20052007
$57,893
$116,486
II
Cybulsky, Myron I
University of
Toronto
Endothelial cell NF-kappaB
signal transduction in
atherosclerosis.
NF-kB, endothelium,
atherosclerosis, hemodynamics,
transgenic mice.
20032007
$101,501
$394,220
I
Cybulsky, Myron I
University of
Toronto
Leukocyte recruitment to
atherosclerosis lesions.
Atherosclerosis, monocytes,
recruitment, survival, adhesion
molecules, M-CSF (CSF1)
20042007
$109,230
$321,482
I
Danckert, James A
University of
Waterloo
Examining the behavioural and
neural effects of prism adaptation in stroke patients suffering
from unilateral neglect.
Neglect, prism adaptation,
rehabilitation, fMRI.
20062008
$42,550
$85,100
II
Drangova, Maria;
Pickering, J
Geoffrey
Robarts Research
Institute
Optimized micro-CT of the
mouse heart and coronary
vasculature.
Three-dimensional micro
computed tomography, murine
coronary artery imaging, vascular biology, murine models of
atherosclerosis, angiogenesis.
20052007
$65,053
$131,188
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
97
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Dumont, Daniel J
Sunnybrook
Health Sciences
Centre
Molecular studies examing
the role of lymphangiogenic
signaling in heart disease.
Lymphangiogenesis, signal
transduction, proteomics,
transgenic animals.
20042007
$74,000
$222,000
I
Duncan, Alison;
Capes, Sarah
E; Darlington,
Gerarda A
University of
Guelph
Effect of soy protein on
glycemic control and serum
lipids in people with type 2
diabetes.
Soy protein, type 2 diabetes,
serum lipids, glycemic control,
cardiovascular disease.
20052007
$56,890
$100,290
I, II
Eikelboom, John
WA; Anand, Sonia
S; Ginsberg, Jeffrey
S; Weitz, Jeffrey I;
Tran, Huyen AM
Hamilton General
Hospital
Determining the mechanisms
of aspirin resistance.
Aspirin, resistance,
cardiovascular disease,
Thromboxane, Rofecoxib.
20052007
$122,900
$242,720
II
Ellis, Christopher G
University of
Western Ontario
Local regulation of microvasculature oxygen exchange.
Oxygen sensor, erythrocyte,
oxygen saturation, oxygen
gradient, regulation.
20052007
$68,384
$138,983
I
Eubanks, James H
Toronto Western
Research Institute
Methyl DNA-binding
factor complexes and
neurodegeneration.
Neuroprotection, methyl DNAbinding factor, epigenetics, cell
biology, mouse model.
20062009
$83,929
$255,036
I
Fehlings, Michael
G; Velumian,
Alexander A
Toronto Western
Research Institute
The ischemic axon: cross-talk
with myelin in K+ channel
terms.
Myelinated axons, oligodendrocytes, glutamate receptors,
K+ channels, conduction block.
20062008
$79,089
$158,178
I
Feindel,
Christopher M;
Borger, Michael A;
Green, Robin EA;
Djaiani, George N;
Ivanov, Joan
Toronto General
Hospital
Minimal invasive cardiac
surgery: is it safe for the brain?
Cardiopulmonary bypass,
neuropsychological
impairment, cerebral emboli,
transcranial Doppler, cardiac
surgery.
20052007
$92,499
$210,998
II
Feindel,
Christopher M;
Vivek, Rao
University Health
Network
Erythropoietin and hypertonic
saline for cardiac transplant.
Cardiac transplant, myocardial
function, cytokine, hypertonic
saline, erythropoietin.
20062009
$92,959
$276,248
I
Feng, Qingping
London Health
Sciences Centre
Neuronal nitric oxide synthase
and heart failure.
Neuronal nitric oxide synthase,
apoptosis, hypertrophy, myocardial infarction, heart failure.
20042007
$66,692
$196,180
I
Feng, Zhong-Ping
University of
Toronto
Modulatory mechansisms
underlying expression of
cardiac voltage-dependent
calcium channels.
Calcium channel density,
surface expression, gene
expression, endocytosis, protein kinases, cardiac myocytes.
20062009
$62,250
$186,750
I
Ferguson, Alastair V
Queen’s University
Orexinergic pathways in central
autonomic control.
Central autonomic control,
peptides, electrophysiology,
cardiovascular regulation,
neuroscience.
20022007
$90,736
$456,383
I
Ferguson, Stephen
SG
Robarts Research
Institute
Regulation of G proteincoupled receptor signaling
desensitization and
esensitization.
Small G proteins, angiotensin,
beta-adrenergic receptor,
desensitization, resensitization,
protein kinases.
20062011
$119,696
$615,378
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
98
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Finestone, Hillel M;
Marshall, Shawn C;
O’Rourke, Keith FP;
Blair, Richard S
Elizabeth Bruyère
Health Centre
Driving post-stroke: a
prospective study of
community integration
and driving habits.
Driving, stroke, community
integration, quality of life.
20052007
$67,618
$134,706
III, IV
Floras, John S
Mount Sinai
Hospital
Cardiovascular regulation in
men and women with heart
failure and hypertension.
Sympathetic nervous system,
heart failure, hypertension,
humans, estrogen.
20022007
$110,777
$535,708
II
Fremes, Stephen
E; Cohen, Eric A;
Desai, Nimesh D
Sunnybrook
Health Sciences
Centre
Graft imaging to improve
patency (GRIIP) study.
Coronary bypass surgery,
intraoperative imaging, clinical
trials, angiography, ultrasound.
20052007
$99,851
$199,702
II
Fremes, Stephen
E; Tu, Jack V;
Anderson, Geoffrey
M; Novick,
Richard J; Guru,
Veena; Rubens,
Fraser D; Mazer,
David; Adhikari,
Neill KJ; Scales,
Damon C; Fowler,
Robert A; Feindel,
Christopher M
Institute for
Clinical Evaluative
Sciences-Toronto
Unraveling the black box of
adverse events in cardiac
surgery.
Adverse events, patient safety,
cardiac surgery, quality of care,
independent audit, best
evidence, best practices, safety
culture.
20062009
$90,350
$260,950
II, III
Funk, Colin D
Queen’s University
COX-2 pathway and
cardiovascular disease.
20062009
$116,208
$353,501
I
Gagnon, France;
Wells, Philip S;
Bulman, Dennis E
University of
Ottawa
Genome-wide search for
oligogenes in factor V Leiden
thrombophilia.
Thrombosis, genetic
epidemiology, quantitative
traits, thrombophilia.
20052008
$55,537
$166,611
I, II
Gaisano, Herbert Y
University of
Toronto
SNARE regulation of cardiac
sulfonylurea receptor, a novel
drug target for cardiac
ischemia.
ATP-sensitive potassium
channels, SNARE proteins,
electrophysiology, cardiac
myocytes, protein interactions.
20052007
$73,848
$146,791
I
Gao, Yu-Jing;
Sharma, Arya M;
Lee, Robert MKW
McMaster
University
Perivascular adiposes tissue,
reactive oxygen species, and
hypertension.
Adipocytes, blood vessels,
contraction, hypertension,
morphology, reactive oxygen
species.
20062007
$35,000
$35,000
I
Garland, S Jayne
University of
Western Ontario
Standing balance following
stroke: a novel approach for
postural muscle retraining.
Balance, stroke,
electromyography,
posturography, rehabilitation.
20052008
$58,215
$175,585
I, II
Giacca, Adria;
Fantus, Ivan G
University of
Toronto
Anti-atherogenic effect of
insulin in vivo.
Hyperinsulinemia, insulin
resistance, restenosis, Apo Enull mouse, atherosclerosis.
20052008
$62,537
$161,456
I, II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
99
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Goldfield, Gary S;
McGrath, Patrick;
Watters, Carolyn R;
Prud’homme, Denis
DP; Hadjiyannakis,
Stasia; Sigal,
Ronald J; Gougeon,
Rèjeanne; Jadad,
Alejandro
Children’s Hospital
of Eastern Ontario
Family-based behavioural
treatment for childhood
obesity delivered via internet:
a randomized controlled trial.
Obesity, children, family-based,
internet, behaviour therapy.
20052007
$49,835
$99,835
II, III
Gollob, Michael H;
Roberts, Robert;
Beanlands, Rob S;
de Kemp, Robert A;
Stewart, Alexandre
FR
University of
Ottawa Heart
Institute
Pathophysiologic study of
the role of AMPK in cardiac
arrhythmias, conduction system
development, and metabolic
cardiomyopathy.
Arrhythmia, cardiomyopathy,
electrophysiology.
20062009
$79,175
$237,047
I, II
Gollob, Michael H;
Roberts, Robert;
Wells, George;
Tang, Anthony
University of
Ottawa Heart
Institute
Genetic predictors of
ventricular arrhythmias in
patients with heart failure.
Genetics, arrhythmias, heart
failure.
20062008
$50,320
$101,850
I, II,
III
Goodman, Jack M;
Sasson, Zion
University of
Toronto
Effects of prolonged
strenuous exercise on left
ventricular function.
Exercise, left ventricle,
contractility, echocardiography.
20062008
$42,490
$83,090
I, II
Graham, Charles H
Queen’s University
Mechanisms regulating
the development and
pathophysiology of
pre-eclamptic hypertension.
Hypertension, pre-eclampsia,
pregnancy, hypoxia, nitric
oxide.
20052007
$91,665
$181,606
I
Graham, Simon J;
Black, Sandra E;
McIlroy, William E;
Staines, W Richard
Sunnybrook
Health Sciences
Centre
Virtual reality for stroke
recovery: initial fMRI studies.
fMRI, stroke recovery, virtual
reality, sensorimotor systems,
simulation.
20052007
$47,080
$95,660
I, II
Gramolini, Anthony
University of
Toronto
Molecular basis of PLN
regulation and function in
cardiac muscle.
Phospholamban, calcium,
cardiac muscle, sarcoplasmic
reticulum, dilated
cardiomyopathy.
20062008
$98,729
$197,404
I, II
Grant, David
R; Levy, Gary;
Gorczynski,
Reginald M;
Phillips, James M;
Adamson, S Lee
Toronto General
Hospital
Role of fgl2 in transplantation
and cardiac development.
Thrombosis, transplantation,
macrophage, endothelial cells,
fibrin.
20052008
$81,655
$234,358
I
Grinstein, Sergio;
Trimble, William S
Hospital for Sick
Children
Dual role of CD36 in macrophages: atherosclerosis and
immune responsiveness.
Macrophage, CD36, receptor,
signal transduction,
endocytosis.
20062010
$80,951
$343,878
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
100
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Gross, Gil J
Hospital for Sick
Children
Ventricular repolarization in
complete heart block.
Complete heart block, cardiac
pacing, repolarizing currents,
ventricular electrical remodeling, autonomic regulation.
20042007
$70,849
$208,406
I
Gross, Gil J;
Redington, Andrew
N
Hospital for Sick
Children
Contractile and electrophysiologic adaptations to constrained heart rate conditions.
Tachycardia, bradycardia,
remodeling, repolarization,
force-frequency relationship.
20062008
$103,631
$209,097
I
Grover, Ashok K
McMaster
University
Caloxins: novel inhibitors of
plasma membrane calcium
pumps.
Calcium pumps, phage display,
drug discovery, cardiovascular.
20062008
$74,608
$150,708
I
Grover, Ashok K
McMaster
University
Receptor stimulated ascorbate
release from endothelial cells.
Vitamin C, endothelium,
coronary artery, shear stress,
oxidative stress.
20042007
$84,701
$249,154
I
Gruenwald,
Colleen; Chan,
Anthony KC;
Holtby, Helen M;
McCrindle, Brian
W; Van Arsdell,
Glen S
Hospital for Sick
Children
Individualized heparin and
protamine management in
infants undergoing
cardiopulmonary bypass for
cardiac surgery reduces
bleeding and blood transfusion
requirements.
Coagulation, infants,
cardiopulmonary bypass (CPB),
heparin, bleeding.
20062008
$57,063
$108,566
II
Gupta, Radhey S
McMaster
University
Studies on adenosine kinase
inhibitors and its gene
regulation.
Adenosine kinase, enzyme
inhibitors, structure-activity
studies, bisphosphonates,
gene regulation, high
throughput-screening.
20042007
$85,343
$243,979
I
Haché, Robert JG
Ottawa Health
Research Institute
Regulation of human primary
preadipocyte differentiation by
glucocorticoids.
Metabolic disease, obesity,
glucocorticoid hormone action,
preadipocyte differentiation,
control of white fat deposition.
20062009
$90,138
$275,858
I
Hammond, James
R
University of
Western Ontario
Role of nucleoside transporters
in the regulation of the vascular
effects of adenosine and its
metabolites.
Transporters, endothelium,
adenosine, oxidative-stress,
preconditioning.
20052008
$70,846
$212,566
I
Hatton, Mark WC;
Clarke, Bryan J
McMaster
University
Comparative study of the procoagulant and pro-fibrinolytic
nature of VX-2 tumours and
their effusions when located in
different body compartments.
Tumour growth, malignant
effusion, hemostasis factors,
platelets, angiogenesis,
anti-angiogenesis.
20052008
$70,435
$211,355
I
Hayward, Catherine
PM
McMaster
University
Structure-function analysis of
multimerin 1 proadhesive
function.
Platelet adhesion, vascular
adhesion, leukocyte adhesion,
aggregation, multimerin 1.
20062009
$137,397
$322,071
I
Hayward, Catherine
PM
McMaster
University
Studies of the mechanisms
involved in generating profibrinolytic and antifibrinolytic
human platelets.
Platelets, fibrinolysis, stroke,
Quebec Platelet Disorder,
urokinase-type plasminogen
activator.
20062009
$80,462
$244,132
I, II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
101
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Hegele, Robert A
Robarts Research
Institute
The phenomics of
atherosclerosis in monogenic
insulin resistance syndrome.
Atherosclerosis biomarkers,
DNA analysis, magnetic
resonance imaging, ultrasound
imaging, insulin resistance
syndrome.
20042007
$65,518
$251,302
I
Heximer, Scott P
University of
Toronto
Defining the role of RGS2 as a
mediator of vascular signaling
and blood pressure regulation.
RGS protein, heterotrimeric
G-protein signaling, hypertension, vascular smooth muscle
cell, cyclic nucleotide-mediated
vasodilation.
20062009
$105,639
$322,874
I
Hinek, Aleksander
Hospital for Sick
Children
Elastin as a crucial factor
modulating cellular proliferation
- relevance to arterial diseases.
20032008
$95,932
$471,977
I
Holbrook, Anne M;
Pereira, Jennifer A;
Thabane, Lehana;
van Walraven, Carl
St. Joseph’s
Hospital
Validation and implementation
of individualized benefit: harm
profiles for opitmal warfarin
prescribing.
Stroke, bleeding, predictor,
benefit:harm analysis, warfarin.
20062008
$9,125
$16,000
II, IV
Holdsworth, David
W; Rankin, Richard
N
Robarts Research
Institute
Investigation of flow in the
stenosed carotid bifurcation.
Stroke, carotid bifurcation
disease, Doppler ultrasound,
hemodynamics, artery-to-artery
embolization.
20032008
$87,104
$422,100
I
Hou, Sheng T
National Research
Council of Canada
(Ottawa)
Semaphorin-3a’s role in axonal
degeneration and regeneration
following cerebral ischemia.
Semaphorin, neuropilin, axon,
regeneration, stroke.
20062009
$59,154
$189,274
I
Hough, Margaret R;
Dick, Alexander J
Sunnybrook
Health Sciences
Centre
Cardiac repair and
regeneration.
Embryonic stem cells, in vivo
differentiation, cardiomyocytes,
cardiac regeneration.
20062009
$84,613
$263,519
I
Huff, Murray W
Robarts Research
Institute
Regulation of ApoB
metabolism: relationship to
atherosclerosis.
20052010
$133,543
$679,770
I
Husain, Mansoor;
Drucker, Daniel J
Toronto General
Hospital
Role of glucagon-like peptides
in cardiac health and disease.
Glucagon peptides &
receptors, myocardial
infarction, heart failure,
transgenic mice, knockout
mice.
20062009
$139,000
$371,349
I
Igdoura, Suleiman
A; Trigatti,
Bernardo L
McMaster
University
Sialidase (neu1) as a novel
risk factor for cardiovascular
disease.
Lipoproteins, atherosclerosis,
macrophage, sialylation, apoE,
LDL.
20062008
$74,175
$157,381
I
Ikura, Mitsuhiko
Princess Margaret
Hospital
Structural elucidation of
intracellular calcium
transporters.
Ca2+ transport, structural
biology, endoplasmic reticulum,
molecular recognition, inositol
20062011
$99,575
$511,985
I
phosphate.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
102
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Irvine, Marilyn Jane;
Stanley, Jill; Dorian,
Paul; Ritvo, Paul
G; Harris, Louise;
Newman, David M;
Sears, Samuel F;
Cribbie, Robert
York University
Psychological support for
implantable defibrillator
patients.
20062008
$91,244
$122,867
II, III
Jaeggi, Edgar T;
Kingdom, John CP;
Keating, Sarah J;
Bradley, Timothy J
Hospital for Sick
Children
Intrauterine growth restriction
with early and late onset
placental insufficiency: impact
on myocardial function and
arterial compliance.
20062008
$38,260
$77,255
I, II
Janssen, Luke J
McMaster
University
Unidentified
endothelium-derived signalling
molecules are isoprostanes.
20042007
$51,368
$154,104
I
Kanji, Salmaan;
Hèbert, Paul C;
Fergusson, Dean;
Tang, Anthony SL;
McIntyre, Lauralyn
A; Dodek, Peter
M; Albert, Martin;
Turgeon, Alexis
F; Pagliarello,
Giuseppe; Marshall,
John C
Ottawa Hospital
General Campus
Atrial fibrillation in the intensive Pilot study, atrial fibrillation,
care unit: a randomized conantiarrhythmic therapy,
trolled trial (Afib ICU study).
intensive care unit, beta
adrenergic blockage, electrical
cardioversion.
20062007
$81,116
$81,116
II
Karmazyn, Morris
University of
Western Ontario
Modulation of cardiomyocyte
hypertrophy by nitric oxide and
endothelin-1 in the aging
myocardium.
Nitric oxide, endothelin,
cardiac hypertrophy, heart
failure, aging, gender.
20052009
$97,637
$395,505
I
Kawaja, Michael D
Queen’s University
Sympathetic hyperinnervation
associated with the
hypertensive phenotype of
rats and mice.
Hypertension, sympathetic,
mesenteric arteries,
neurotrophin, transgenic.
20052008
$71,002
$218,397
I
Kearon, Clive;
Bates, Shannon M;
Linkins, Lori-Ann;
Julian, James A;
Ginsberg, Jeffrey
S; Kahn, Susan R;
Douketis, James D
Hamilton Civic
Hospital Research
Centre
Selective D-dimer testing for
diagnosis of deep vein
thrombosis.
20042007
$121,935
$359,515
II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Vascular smooth muscle,
endothelium, ion channels,
intracellular signalling,
hypertension.
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
103
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Kearon, Clive;
Ginsberg, Jeffrey S;
Julian, Jim A; Kahn,
Susan R; Wells,
Philip S; Douketis,
James D
McMaster
University
Thrombosis in family members
of patients with unprovoked
venous thromboembolism.
Venous thrombosis,
thrombophilia, clinical
management, screening,
counselling.
20052007
$68,985
$136,139
I, II,
III, IV
Keeley, Fred W
Hospital for Sick
Children
Recombinantly expressed
polypeptides of human elastin
as a novel tool for investigations
of the structure, self-assembly
and properties of elastin-like
materials.
Elastin, elastic tissue, blood
vessels, extracellular matrix,
biomaterial
20042009
$111,517
$557,707
I
Kelton, John G;
Moore, Jane C;
Begbie, Megan E
McMaster
University
Platelet-mediated acute
thrombotic disorders.
Platelets, immune,
thrombocytopenia, heparin,
thormbosis.
20052010
$141,157
$726,784
I, II
Khokha, Rama
Ontario Cancer
Institute
Molecular dissection of the
distinct functions of TIMP-3
and TIMP-4 in heart disease.
TIMP deficiency,
metalloproteinase, cytokines,
ECM, heart disease.
20062009
$75,861
$227,583
I
Koschinsky, Marlys
L
Queen’s University
Interactions of Lp(a) with the
plasminogen system: mechanisms and pathophysiological
consequences.
Lipoprotein(a), apoliprotein(a),
plasminogen, thrombosis,
atherosclerosis.
20052010
$98,050
$493,817
I
Koschinsky, Marlys
L
Queen’s University
The pathophysiology of Lp(a) in
the arterial wall: effect of apo(a)
on vascular cell function.
Lipoprotein(a),
apolipoprotein(a), kringles,
atherosclerosis, endothelial
dysfunction.
20062011
$96,899
$503,083
I
Krahn, Andrew D;
Gollob, Michael H;
Birnie, David H
University of
Western Ontario
Clinical and genetic
assessment of primary
electrical disease.
Cardiac arrest, genetics,
diagnosis, sudden death, drug
infusion, genetic testing.
20062009
$94,976
$288,299
II
Kutryk, Michael JB
St. Michael’s
Hospital
Novel applications of
progenitor endothelial cells.
Progenitor endothelial cells,
iPAH, HHR, angiogenesis,
cardiac risk factors.
20052007
$43,450
$86,047
I, II
Lanctôt, Krista L;
Sahlas, Demetrios
J; Gladstone, David
J; Ween, Jon Erik;
Herrmann, Nathan;
Black, Sandra E
Sunnybrook
Health Sciences
Centre
The role of cytokine-serotonin
interactions in post-stroke
depression.
Stroke, depression, tryptophan,
serotonin, cytokines.
20062008
$57,770
$108,715
I, II
Langille, B Lowell
Toronto General
Hospital
Arterial responses to
hemodynamic stresses.
Remodeling,
mechanotransduction, shear,
tensile stress, elastin.
20022007
$113,203
$551,675
I
Langille, B Lowell;
Bendeck, Michelle
P
Toronto General
Hospital
Cadherins and regulation of
smooth muscle cell function.
Cadherin, polarity, migration,
vascular smooth muscle,
restenosis.
20042007
$75,845
$225,053
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
104
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Lee, Robert MKW;
Gao, Yu-Jing
McMaster
University
Alterations in hypertensive
arteries.
Hypertension, artery, fat,
vascular remodeling, vascular
growth.
20052008
$80,112
$234,997
I
Leenen, Frans HH
University of
Ottawa Heart
Institute
Sympathetic and cardiac
effects of blockers in the RAAS
in rats.
Brain, heart, renin-angiotensinaldosterone system, heart
failure, blockers, sympathetic
nerve activity.
20042007
$98,157
$276,923
I
Leong-Poi, Howard
M; Stewart, Duncan
J; Gross, Peter L
St. Michael’s
Hospital
Site-targeted imaging and
delivery of cell-based therapy.
Endothelial progenitor cells,
targeted ultrasound imaging,
therapeutic angiogenesis,
chronic ischemia.
20062008
$73,682
$148,264
I
Letarte, Michelle V
Hospital for Sick
Children
Role of endoglin in normal
vasculature and in the
pathology of HHT.
Vascular tone, endoglin, HHT,
Vascular endothelium, gene
profiling.
20052009
$91,804
$370,767
I
Lewis, Gary F
Toronto General
Hospital
Regulation of HDL metabolism.
HDL, apolipoprotein A,
hypertriglyceridemia, lipase.
20052008
$86,151
$260,873
I, II
Leytin, Valery;
Gross, Peter L
St. Michael’s
Hospital
Platelet apoptosis induced by
chemical agonists and shear
stresses.
Platelets, apoptosis,
thrombosis, collagens,
shear stress.
20052008
$83,023
$242,521
I
Li, Ren-Ke; Fedak,
Paul W
Toronto General
Hospital
Gene-enhanced cell
transplantation to reverse
heart failure.
Heart failure, growth factor,
cell transplantation, myocardial
hypertrophy, extracellular matrix.
20042007
$88,122
$259,216
I
Li, Ren-Ke
Toronto General
Hospital
Vasculogenesis induced by cell
transplantation.
Angiogenesis, cell transplantation, myocardial ischemia,
cell culture, growth factors.
20032007
$90,901
$345,259
I
Lillicrap, David;
James, Paula D
Queen’s University
The role of von Willebrand
factor in arterial thrombosis.
von Willebrand factor, arterial
thrombosis, genetics, mouse
model.
20052008
$91,857
$275,669
I, II
Liu, Fang
Centre for
Addiction and
Mental Health
Uncoupling the protein-protein
interaction between mGluR5
and NMDA receptors: a new
approach in the treatment of
stroke.
Metatropic glutamate
receptors, NMDA receptors,
neurotoxicity, protein-protein
interaction, stroke.
20052007
$49,022
$98,044
I
Liu, Peter P; Hinek,
Aleksander
Toronto General
Hospital
Aldosterone - receptor and
non-receptor based mechanisms of repair and remodeling
following cardiac injury.
Aldersterone, remodeling,
inflammation, signal
transduction, elastase.
20042007
$100,513
$295,665
I
Liu, Peter P; Medin,
Jeffrey A
Toronto General
Hospital
Homing signals and cell
mobilization in cardiac
remodeling post myocardial
infarction.
Heart failure, remodeling,
cytokines, stem cells, progenitor
cells, homing, innate immunity.
20062009
$95,158
$290,233
I, II
Liu, Peter P;
Stewart, Duncan J
Toronto General
Hospital
T-cell based immune
mechanisms of chlamydial
vascular injury.
Chlamydia, vascular injury,
immune mechanisms,
atherosclerosis.
20032008
$113,493
$556,560
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
105
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Liu, Peter P; Yeh,
Wen-Chen
Toronto General
Hospital
“Danger signal”, cell injury and
“innate immune response” in
regulating inflammation in
cardiovascular disease.
Inflammation, myocarditis,
innate immunity, vaccine, heart
failure.
20052010
$106,750
$544,636
I, II
Lobe, Corrinne
Sunnybrook
Health Sciences
Centre
Transgenic mouse models
to study the role of Notch in
blood vessel development.
Notch pathway, transgenic
mice, angiogenesis.
20042007
$74,334
$221,640
I
Lucas, Alexandra R;
Spence, J David
Robarts Research
Institute
Serpin regulation of innate
immune response and vascular
repair.
Serpins, viral, inflammation,
atherosclerosis, thrombolysis.
20062009
$78,892
$236,676
I
MacLennan, David
H
University of
Toronto
Sites of interaction between
phospholamban, sarcolipin and
the cardiac calcium pump.
20022007
$138,229
$664,375
I
Mak, Alan S
Queen’s University
Cortactin and caldesmon in
vascular smooth muscle cell
migration and invasion.
Smooth muscle, cell motility,
atherosclerosis, biochemistry,
cell biology.
20062011
$93,313
$484,502
I
Mak, Susanna
Mount Sinai
Hospital
Estrogen and cardiac function
in humans with and without
heart failure.
Sex, estrogen, ventricular
function, heart failure.
20052007
$51,123
$101,705
II
Marcel, Yves L; Kiss,
Robert S
University of
Ottawa Heart
Institute
Role of GULP in engulfment
and cellular cholesterol
trafficking.
GULP, cholesterol, efflux,
engulfment, macrophages.
20062007
$35,000
$35,000
I
Marcel, Yves L;
McPherson, Ruth
University of
Ottawa Heart
Institute
The genetic basis of
cholesterol efflux defects in
hypoalphalipoproteinemia.
Atherosclerosis,
dyslipoproteinemia,
cholesterol, efflux, lipoproteins.
20062009
$92,583
$280,989
I
Marsden, Philip A
University of
Toronto
Post-transcriptional regulation
of eNOS expression.
Nitric oxide, endothelium,
atherosclerosis, transcription,
translation.
20052009
$95,069
$380,276
I
Marsden, Philip A
University of
Toronto
Regulated expression of the
human nNOS gene.
Atherosclerosis, hypoxia,
translation, nitric oxide,
transcription.
20062011
$109,203
$562,240
I
Marshall, John G;
Cass, Dan
Ryerson
Polytechnic
University
Biophysical and biochemical
approaches to the diagnosis
of myocardial infarction and
stroke.
Serum, diagnostic, mass
spectrometry, atherosclerosis,
lovastatin.
20052007
$69,188
$143,088
I, II
Martin, Ruth E;
Hachinski, Vladimir
University of
Western Ontario
Effects of oropharyngeal
stimulation on swallowing
recovery and cortical plasticity
in hemispheric stroke: a randomized controlled trial with fMRI.
Stroke, dysphagia, swallowing,
orofacial, functional magnetic
resonance imaging.
20042007
$87,700
$268,107
II
Maurice, Donald H
Queen’s University
PDEs in blood vessels.
cAMP, cGMP, sinalling, smooth
muscle, endothelium.
20042008
$95,399
$379,466
I
McBride, Heidi M
University of
Ottawa Heart
Institute
Mechanism and function of
mitochondrial derived vesicles.
Mitochondrial dynamics,
MARi-1, DRP1, budding.
20062008
$84,892
$171,665
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
106
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
McCrindle, Brian
W; Russell, Jennifer;
Sananes, Renée;
Longmuir, Patricia
Hospital for Sick
Children
Identifying determinants and
optimizing rehabilitation of
physical activity for children
after the Fontan Procedure.
Fontan procedure, physical
activity, behaviour change,
psychosocial factors, children.
20062008
$62,184
$119,967
II
McCulloch,
Christopher AG;
Seth, Arun
University of
Toronto
Regulation of smooth muscle
gene expression by mechanical
loading.
Actin, cardiac fibrosis,
myofibroblast, mechanical
tension, MAP kinases.
20042007
$90,653
$267,562
I
McDermott, John C
York University
Role of MEF2 interacting
proteins in cardiac
development and hypertrophy.
Cardiomyocytes, transcription,
MEF2, gene expression,
hypertrophy.
20062007
$35,000
$35,000
I
McPherson, Ruth
University of
Ottawa Heart
Institute
Regulation of LRP gene
expression.
LRP, gene expression,
adipocytes, lipoproteins.
20042007
$65,661
$193,252
I
Megeney, Lynn
Ottawa Health
Research Institute
Non-linear modeling of MAPK
induced cardiac hypertrophy.
20052007
$67,745
$135,490
I
Mehta, Sanjay;
McCormack, David
G
Lawson Research
Institute
Microvascular endothelial cell
injury in murine sepsis.
Microvasculature, sepsis,
endothelial cell, nitric oxide,
neutrophil.
20052008
$89,805
$277,415
I
Melo, Luis G; Dzau,
Victor J; Pachori,
Alok
Queen’s University
Cell based gene therapy to
enhance healing and recovery
of infarcted myocardium.
Endothelial progenitor cell
(EPC), genetic engineering,
myocardial infarction,
neovascularization.
20052007
$91,435
$181,341
I
Melo, Luis G; Ward,
Christopher A
Queen’s University
Cardiogenic differentiation of
mesenchymal stem cells using
transcription factors.
Genetic engineering,
lentivirus, mesenchymal stem
cells, myocardial repair,
transcription factors.
20062008
$81,959
$164,958
I
Miller, Judith A;
Cherney, David ZI
Toronto General
Hospital
Impact of protein kinase C
inhibition on hemodynamic
function in type 1 diabetes
mellitus.
Protein kinase C, physiology,
diabetes, hyperglycemia,
angiotensin II.
20042007
$64,558
$127,850
II
Milne, Ross W;
Braschi, Sylvie F;
Whitman, Stewart C
University of
Ottawa Heart
Institute
Advanced glycation end
products and diabetic
atherosclerosis.
Advanced glycation end products, diabetes, atherosclerosis, transgenic mice.
20052007
$67,570
$133,815
I
Min, Wei-Ping
London Health
Sciences Centre
Cellular therapy for transplant
rejection by T regulatory cells
generated through interaction
with genetically modified
dendritic cells.
Heart transplantation,
tolerance, dendritic cell,
RNA interference, immune
modulation.
20052007
$70,667
$140,438
I
Min, Wei-Ping
London Health
Sciences Centre
Protection of heart grafts in
transplantation through RNA
interference.
Heart transplantation, gene
silencing, siRNA, immune
tolerance, ischemia/reperfusion
injury.
20062008
$76,140
$153,793
I
Monnier, Philippe P
Toronto Western
Research Institute
Mechanisms that control
repulsive guidance molecule
(RGM) biological activity.
Neuronal survival,
neuroregeneration, axonal
outgrowth, brain ischemia, biochemistry, molecular biology.
20052007
$68,970
$137,940
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
107
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Morley, Paul
National Research
Council of Canada
(Ottawa)
Synaptic and extrasynaptic
NMDA receptors in
preconditioning.
Preconditioning, tolerance,
ischemia, stroke, neurotoxicity.
20052008
$66,024
$198,097
I
Murkin, John M;
Walley, Keith R;
Sandford, Andrew
J; Russell, James
A; Lichtenstein,
Samuel V
London Health
Sciences Centre
Genetic determinants of
cognitive dysfunction following
cardiopulmonary bypass.
Cardiopulmonary bypass,
genes, polymorphisms,
cognitive dysfunction.
20042007
$93,972
$276,424
III
Nesheim, Michael E
Queen’s University
The activation of TAFI and the
properties of TAFIa.
TAFI, TAFIa, fibrinolysis,
x-ray crystallography,
thrombomodulin.
20052010
$86,077
$442,097
I, III
Newton, Gary E
Mount Sinai
Hospital
Free radical modulation of
sympathetic activity and
mechanical efficiency in the
normal and failing human
heart.
Free radicals, heart failure,
norepinephrine spillover,
mechanical efficiency, vitamin
C, nitric oxide.
20052008
$64,264
$192,792
I, II
Newton, Gary E;
Allard, Johanne
Mount Sinai
Hospital
Investigations in dietary
therapy in human heart failure.
Heart failure, diet, sodium,
hemodynamics, norepinephrine.
20062008
$57,450
$114,900
I, II
Ni, Heyu
St. Michael’s
Hospital
Novel mechanisms of platelet
aggregation: role of alternative
ligands of beta3 integrin in
thrombosis and hemostasis.
Platelet, thrombosis, integrin,
hemostasis, vascular biology.
20052008
$65,517
$196,575
I
Nurse, Colin A
McMaster
University
Mechanisms regulating
asphyxial responses in rat
adrenal chromaffin cells.
Chromaffin cells, asphyxia,
patch clamp, nicotine, culture.
20062010
$104,641
$357,709
I, II,
III, IV
O’Brien, Edward
RM
University of
Ottawa Heart
Institute
NM23-H2, an estrogen
receptor beta associated
protein: alterations in signal
regulation and role in vascular
cell function.
Estrogen, receptors,
atherosclerosis, coronary,
hormones.
20052008
$70,284
$210,909
I, II,
IV
O’Brodovich, Hugh
M
Hospital for Sick
Children
New approach to augment
clearance of pulmonary edema.
20052008
$84,980
$270,832
I
O’Leary, Deborah
D; Klentrou,
Panagiota; Falk,
Bareket; LeBlanc,
Paul J
Brock University
The effects of body
composition on arterial
stiffness and baroreflex
function in children.
Obesity, children, arterial
stiffness, baroreflex function,
gender.
20062008
$47,935
$95,870
I
Opas, Michal
University of
Toronto
Calreticulin: cell and
developmental biology.
Calreticulin, calcium,
adhesion, ES cells,
differentiation, microscopy.
20042007
$100,003
$300,009
I
Opavsky, Mary
Anne
Hospital for Sick
Children
The coxsackie-adenovirus
receptor: function meets infection in viral myocarditis and
dilated cardiomyopathy.
Myocarditis, coxsackievirus,
signal transduction,
coxsackie-adenovirus receptor,
MAPKs.
20052007
$86,858
$172,014
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
108
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Pandey, Siyaram;
Tanner, WR
University of
Windsor
Identification and functional
characterization of unique
single domain intrabodies
against pro-apoptotic proteins
and their application in the
discovery of novel
pharmacophore.
Intrabodies, apoptosis,
neuronal cell death, ischemia,
anti-apoptotic intrabodies,
phage display and
pharmacophore libraries.
20062009
$77,000
$198,000
I
Pang, Stephen C
Queen’s University
Pathogenesis of cardiac
hypertrophy in ANP gene
disrupted mice.
Atrial natriuretic peptide, renin
angiotensin system, cardiac
hypertrophy, salt-sensitive
hypertension, gene knockout
mice.
20042007
$81,123
$238,629
I
Park, David S
University of
Ottawa
Oxidative stress and ischemic
death.
Stroke, oxidative stress.
20062008
$68,000
$137,160
I
Park, David S;
Albert, Paul
University of
Ottawa
Mechanisms of delayed death
in stroke.
Central nervous system, stroke,
behaviour abnormalities.
20042009
$80,600
$403,000
I
Parker, John D
Mount Sinai
Hospital
Neurochemical effects of different pacing modalities in CHF:
insights from studies of cardiac
and renal sympathetic activity.
20042007
$100,215
$300,645
II
Parkinson, John;
Keeley, Fred W
Hospital for Sick
Children
A combined theoretical/
experimental approach to
understanding sequence
- structure - function relationships in elastin and elastin-like
peptides.
Elastin, biomechanics,
bioinformatics, self-assembly,
computer simulation.
20052007
$36,271
$74,831
I
Parshuram,
Christopher S;
Hutchison, James
S; Parkin, Patricia;
Beyene, Joseph;
Dryden-Palmer,
Karen
Hospital for Sick
Children
PEWS translation project: from
retrospective algorithm to
real-time bedside tool.
Prevention, patient safety, early
warning system.
20062008
$74,652
$147,643
II, III
Peng, Tianqing;
Feng, Qingping
London Health
Sciences Centre
PLCgamma/IP3 signaling
regulates cardiac TNF-alpha
expression in sepsis.
Sepsis, TNF-alpha, cardiomyocyte, phospholipase Cgamma,
inositol trisphosphate.
20062009
$127,384
$323,859
I
Pickering, J
Geoffrey
Robarts Research
Institute
Regulation of smooth muscle
cell differentiation and
longevity.
Smooth muscle cell, cell
maturation, cell longevity,
NAD, vessel remodeling.
20052010
$103,128
$526,159
I
Puri, Mira C
Sunnybrook
Health Sciences
Centre
Role of endoglin in mammalian
cardiovascular development.
Endothelium, endocardial
cushion, embryogenesis,
mouse models, arteriovenous
malformation.
20062008
$69,349
$138,698
I
Pyle, William Glen
University of
Guelph
Hormonal regulation of
myocardial function.
Relaxin, myofilaments,
intracellular signalling,
mechanics, myocardium.
20052007
$53,560
$105,761
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
109
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Rand, Margaret L
Hospital for Sick
Children
The procoagulant surface of
activated platelets: persistence
in vitro and in vivo.
Platelets, thrombosis,
procoagulant activity, platelet
survival.
20042007
$80,092
$235,594
I
Rao, Vivek
University of
Toronto
Mechanisms of transplant
related vascular injury.
Endothelial injury,
immunosuppression,
endothelin, protein kinase C.
20062008
$63,000
$127,260
I
Reid, Robert D;
Pipe, Andrew L;
Morrin, Louise IN;
Higginson, Lyall
AJ; Wells, George
A; Blanchard, Chris
M; Oldridge, Neil;
Wielgosz, Andreas
T
University of
Ottawa Heart
Institute
Efficacy and cost-effectiveness
of behavioural counselling for
exercise behaviour in men and
women following AMI and PCI.
Coronary artery disease,
secondary prevention, early
intervention, physical activity.
20052007
$70,322
$147,319
II, III
Reid, Robert D;
Pipe, Andrew L;
Sherrard, Heather
University of
Ottawa Heart
Institute
An interactive, voice
response-mediated, follow-up
and triage system for smoking
cessation in smokers with CHD.
Smoking cessation, coronary
disease, prevention, interactive
voice response.
20062009
$72,820
$177,557
II, III,
IV
Renaud, Leo P
Ottawa Health
Research Institute
Suprachiasmatic nucleus
efferents.
Patch clamp, cell electrophysiology, transmitters, biological
clock, hypothalamus.
20052008
$58,207
$179,692
I
Robinson, Lisa A
Hospital for Sick
Children
Cellular regulation of
fractalkine.
20052007
$85,972
$171,944
I
Rochon, ELizabeth
A; Leonard, Carol
L; Grady, Cheryl;
Graham, Simon J
University of
Toronto
Neural, linguistic, and
communicative changes after
treatment for anomia in
aphasia.
Aphasia, rehabilitation,
neuroimaging, communication.
20042007
$110,885
$323,604
I
Rodger, Marc A;
Walker, Mark C;
Kingdom, John;
Keating, Sarah J;
Wen, Shi Wu; Yang,
Qiuying; Smith,
Graeme N
Ottawa Health
Research Institute
TAPP - Thrombophilia and
Placental Pathology.
Pregnancy complications,
cohort study, thrombophilia,
placental villous infarction.
20052008
$41,080
$123,849
I, II,
III, IV
Roy, Eric A;
Black, Sandra E;
Dixon, Michael J;
Danckert, James;
Park, Norman W;
Adams, Scott;
Hebert, Deborah
University of
Waterloo
Neuropsychological profiles
and neuroimaging correlates
of limb apraxia.
Apraxia, aphasia,
cognitive neuroscience,
neuropsychology, cognitive
neurology, movement control,
manual asymmetries.
20042007
$45,643
$136,929
II
Rubin, Barry B;
Degousee, Norbert
Toronto General
Hospital
Impact of mPGES-1 gene
deletion on myocardial
ischemia reperfusion injury.
Prostaglandins, myocardial
ischemia, heat shock proteins,
mesenchymal stem cell,
transgenic mice.
20052007
$79,511
$156,819
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
110
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Ruel, Marc;
Beanlands, Rob SB;
Suuronen, Erik J;
de Kemp, Robert
A; DaSilva, Jean N;
Veinot, John P
University of
Ottawa Heart
Institute
Evaluation of biopolymer delivered EPCs for cardiac repair in
a swine model of hibernating
myocardium.
Tissue engineering, endothelial
progenitor cells, hibernating
myocardium, animal models,
PET.
20062008
$86,364
$175,743
I
Rush, James WE
University of
Waterloo
Exercise and antioxidants in
hypertension: vascular
endothelial adaptations.
Exercise, hypertension, vascular
endothelium, nitric oxide,
oxidative stress.
20052007
$63,745
$126,241
I
Schlichter, Lyanne C
Toronto Western
Research Institute
Novel strategies to regulate
microglia activation and
neurotoxicity.
Potassium channels, CNS
inflammation, immune-cell
activation.
20062009
$107,528
$280,936
I
Schlichter, Lyanne
C; Peeling, James;
Corbett, Dale R
Toronto Western
Research Institute
Targeting K channels to control
inflammation in stroke.
Intracerebral hemorrhage,
focal ischemia, retinal ischemia,
optic nerve transection,
potassium channels, CNS
inflammation, immune-cell
activation.
20052008
$101,759
$312,391
I
Sharma, Arya M;
Anand, Sonia
S; Tarnopolsky,
Mark; Yusuf, Salim;
Gerstein, Hertzel C;
Pogue, Janice M
McMaster
University
Biological determinants of
the differences in metabolic
and cardiovascular risk factors
between South Asians and
European caucasians.
Ethnicity, obesity, diabetes,
adipose tissue, skeletal muscle.
20052008
$99,304
$253,610
I, II,
IV
Sheffield, William P
McMaster
University
Building novel antithrombotic
serpins using directed or selectable mutational approaches.
Serpins, thrombosis, protein
engineering, thrombin,
coagulation.
20052008
$64,416
$194,765
I
Sheffield, William P
McMaster
University
The clot-targeting properties
of natural and engineered
antiplasmins.
Fibrinolysis, antiplasmin, fibrin,
cross-linking, hirudin.
20062009
$80,694
$245,991
I
Shoemaker, J
Kevin; Cechetto,
David F
University of
Western Ontario
Central sympathetic control in
humans.
Functional magnetic resonance
imaging, brain stem,
sympathetic nerve activity,
human, baroreceptors,
sympathoinhibition.
20042007
$71,149
$212,491
II
Silverman, Earl
D; Bargman,
Joanne M; Bradley,
Timothy; Beyene,
Joseph
Hospital for Sick
Children
Role of chronic inflammation
and systemic lupus erythematosus-related factors in the
development of premature
atherosclerosis in pediatric SLE.
Atherosclerosis, systemic lupus
erythematosis, risk factors for
atherosclerosis, pediatrics,
surrogate markers of
atherosclerosis.
20062009
$120,545
$386,777
II, IV
Silversides, Candice
K; Siu, Samuel C;
Colman, Jack M;
Sermer, Mathew
Toronto General
Hospital
Hemodynamic and hormonal
changes in pregnant women
with cardiac disease: understanding the effects of
pregnancy on the disease heart.
Pregnancy, heart disease,
echocardiography,
neurohormones.
20062008
$37,744
$75,488
II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
111
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Siu, Samuel C;
Colman, Jack M;
Sermer, Mathew
Toronto General
Hospital
Maternal cardiac output and
fetal well being in women with
heart disease.
Fetal well-being, maternal
cardiac output.
20052007
$45,400
$90,800
II
Slack, Ruth S
University of
Ottawa
Regulation of MCL-1 to treat
stroke.
Stroke, apoptosis, neurons,
transgenic mice, molecular.
20062011
$98,632
$507,077
I
Sled, John G;
Adamson, S Lee;
Kingdom, John;
Langille, B Lowell
Hospital for Sick
Children
Three dimensional quantification of the placental vascular
tree: relationship with normal
and abnormal fetal growth and
hemodynamics.
Intrauterine growth restriction,
micro-CT, placenta,
microcirculation.
20062008
$65,283
$132,171
I, II
Smith, Steven P
Queen’s University
Structural mechanisms of
apolipoprotein(a)-ligand
interactions: roles in Lp(a)
assembly and function.
Lipoprotein(a),
apolipoprotein(a), kringle
modules, protein-protein
interactions, structural biology,
atherosclerosis.
20062007
$35,000
$35,000
I
Sorisky, Alexander
Ottawa Health
Research Institute
Regulation of the pro-atherogenic adipokine IL-6 by TSH.
20042007
$87,154
$257,478
I
Sparks, Daniel L
University of
Ottawa Heart
Institute
Regulation of ApoA-I
synthesis and secretion by
phosphatidylinositol.
HDL, cholesterol,
atherosclerosis, lipid
metabolism, liver, intestine.
20062009
$98,580
$300,608
I
Sparks, Daniel L
University of
Ottawa Heart
Institute
The role of HDL in triglyceride
metabolism.
HDL, cholesterol,
apolipoproteins, lipases,
heart disease.
20052008
$66,782
$197,087
I
Spence, John
David; Lucas,
Alexandra R;
Madrenas, Joaquin;
Hegele, Robert A
Robarts Research
Institute
Biomarkers in vulnerable
carotid plaque with
microemboli or ulcers.
Atherosclerosis,
hypothyroidism, clinical
trials, 3D ultrasound plaque
measurement.
20052008
$96,594
$289,820
I, II
Spence, John
David; Parraga,
Grace; House,
Andrew A; Fenster,
Aaron
Robarts Research
Institute
3D ultrasound phenotypes and
vascular risk.
Atherosclerosis, vulnerable
plaque, plaque volume,
ulceration, cardiovascular risk.
20062009
$77,650
$276,529
II
Stanimirovic, Danica
B; Moreno, Maria J
National Research
Council of Canada
(Ottawa)
Astrocyte-endothelial cell
interactions in hypoxia: role of
P1GF in hypoxia-induced brain
angiogenesis.
Hypoxia, brain angiogenesis,
neurovascular unit,
placenta-growth factor, VEGF.
20062009
$71,000
$216,866
I
Stewart, Duncan J;
Husain, Mansoor;
Han, Robin NN
St. Michael’s
Hospital
NO synthase in cardiovascular
health and disease.
20052008
$92,651
$278,047
I
Sweeney, Gary
York University
Regulation of glucose and fatty
acid uptake and metabolism in
cardiomyocytes by adiponectin.
20052007
$63,000
$126,000
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
112
Adiponectin, glucose, fatty acid,
obesity, diabetes.
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Tein, Ingrid
Hospital for Sick
Children
Carnitine-responsive
cardiomyopathy and the
different-affinity carnitine
transporters.
Carnitine metabolism,
carnitine transport, kinetic
studies, expression studies,
mouse model.
20042007
$88,826
$264,899
I
Templeton, Douglas
M
University of
Toronto
Mechanisms of iron accumulation and toxicity in cardiac myocytes and interstitial fibroblasts.
Iron overload, cardiac fibrosis,
iron transport, cardiomyocyte,
myofibroblast.
20052007
$73,030
$144,999
I
Tesson, Frederique;
Leenen, Frans HH;
Ruel, Marc
University of
Ottawa Heart
Institute
Genetic approach to heart
failure.
Heart failure, human molecular
genetics, candidate genes,
expression levels, genetic risk
factors.
20062008
$33,900
$68,178
I, II,
IV
Touyz, Rhian M
University of
Ottawa
Vascular regulation by
magnesium in hypertension.
Magnesium, vessels,
hypertension, oxidative stress,
ion transport.
20052008
$95,704
$287,150
I
Trigatti, Bernardo L
McMaster
University
Effects of tissue specific expression or suppression of the HDL
receptor SR-BI on atherosclerosis and coronary artery disease.
Transgenic, knockout, HDL
receptor, atherosclerosis,
coronary artery disease.
20042007
$84,392
$250,809
I
Tsushima, Robert G
University of
Toronto
Regulation of cardiac
nonselective cation channels.
TRPC channels, electrophysiology, cardiac myocytes, caveolin,
SNARE proteins.
20052007
$75,719
$150,514
I
Tsushima, Robert G;
Gaisano, Herbert Y
University of
Toronto
SNARE protein modulation of
cardiac Kv channels.
Potassium channels, calcium
channels, SNARE proteins,
SLMAP, electrophysiology.
20062009
$78,002
$238,369
I
Tu, Jack V; Alter,
David A; Austin,
Peter C; Ko, Dennis
T; Lee, Douglas
SY; Juurlink, David
N; Mamdani,
Muhammad M
Institute for
Clinical Evaluative
Sciences-Toronto
Improving the quality of acute
myocardial infarction care in
Canada.
Acute myocardial infarction,
health services research, quality
of care, mortality, drug
utilization, quality indicators.
20052008
$125,663
$377,033
II, III,
IV
Tuana, Balwant S
University of
Ottawa
SLMAPs: sarcolemmal
membrane associated proteins
and E-C coupling.
Sarcoplasmic reticulum,
sarcolemma, membrane targeting, coiled-coil, E-C coupling.
20062010
$139,652
$567,651
I, II
Tyml, Karel; Laird,
Dale W
University of
Western Ontario
Hypoxia/reoxygenation and
vascular cell coupling.
Microcirculation, capillary,
endothelial cell, ischemia,
reperfusion.
20052008
$92,527
$277,614
I
Tyml, Karel; Wilson,
John X; Kidder,
Gerald
Lawson Research
Institute
Microvascular dysfunction in
sepsis.
Microcirculation, capillary,
endothelial cell, sepsis.
20062008
$92,724
$187,066
I
Van Arsdell, Glen S;
Li, Jia; Redington,
Andrew N
Hospital for Sick
Children
Analysis of the mechanism of
altered systemic and cerebral
oxygen transport in children
with hypoplastic left heart
syndrome undergoing stage I
palliation.
Oxygen transport, Norwood
procedure, hypoplastic left
heart syndrome, postoperative
management, brain oxygenation.
20062009
$87,000
$264,428
II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
113
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Verma, Subodh;
Stanford, William L
St. Michael’s
Hospital
RasGRP3: a novel signaling protein and molecular target
for endothelial progenitor
cell mobilization and
neovascularization.
Vascular biology, angiogenesis,
experimental mice models,
ischemia.
20062008
$74,655
$151,767
I
Wan, Qi
Toronto Western
Hospital
PTEN suppression-mediated
neuroprotection in stroke.
Stroke, neuroprotection, PTEN
phosphatase, NMDA receptor
trafficking, signal transduction
pathway.
20062008
$76,939
$154,851
I
Wang, Hao; Zhong,
Robert
University of
Western Ontario
Tolerance induction through
targeting memory T cells by
blocking OX40 signaling pathway in presensitized recipients.
20062008
$80,626
$161,729
I
Wang, Rui
Lakehead
University
Role of BKCa channels of vascular smooth muscle cells in the
development of hypertension.
K channels, carbon monoxide,
vascular contraction, smooth
muscle cells, hypertension.
20062007
$65,000
$65,000
I
Warkentin,
Theodore E;
Morgan, David G;
Moore, Jane C
McMaster
University
vWF multimers, cardiovascular
disease, and bleeding
angiodysplasia.
von Willebrand factor, multimer,
shear-dependent proteinase,
aortic stenosis, peripheral
vascular disease.
20042007
$92,383
$271,745
II
Weisel, Richard D;
Fazel, Shafie
Toronto General
Hospital
Cardiac regeneration by cell
transplantation.
Myocardial infarction,
ventricular remodeling,
cardiac regeneration, matrix
remodeling, angiogenesis.
20062009
$69,424
$212,216
I
Weisel, Richard D;
Fazel, Shafie
Toronto General
Hospital
Enhancing endogenous repair
by cell therapy.
Myocardial infarction,
ventricular remodeling,
cardiac regeneration, matrix
remodeling, angiogenesis.
20052007
$68,192
$136,384
I
Weitz, Jeffrey I
McMaster
University
Mechanisms of coronary
catheter-induced clotting.
Percutaneous coronary interventions, thrombosis, contact
pathway anticoagulants.
20062010
$112,788
$462,837
I
Weitz, Jeffrey I;
Klement, Petr
McMaster
University
Improving the effectiveness of
thrombolytic therapy.
Coagulation, fibrinolysis,
anticoagulants, plasminogen
activators, thrombolysis.
20042008
$110,288
$438,223
I
Wells, James W
University of
Toronto
Nature of the signalling
complex between cardiac
muscarinic receptors and G
proteins.
Heart disease, muscarinic
cholinergic receptor, G protein,
co-operativity, oligomers,
signalling mechanism.
20052008
$83,433
$254,801
I
Wells, Philip S;
Kahn, Susan R;
Anderson, David R;
Ottawa Health
Research Institute
The role of inflammation and
thrombophilia in the postthrombotic syndrome: the
bio-sox study.
Post-thrombotic syndrome,
predictors, thrombophilia, SNP
analysis, inflammation, D-dimer.
20052007
$48,670
$99,115
II
Genest, Jr, Jacques;
Kovacs, Michael J;
Rodger, Marc A;
Shapiro, Stanley H
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
114
06-07 $
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
co-chercheur(s)
principal
Wen, Shi Wu;
Walker, Mark C;
Krewski, Daniel;
Smith, Graeme N;
Yang, Qiuying
Ottawa Health
Research Institute
Environmental carbon
monoxide (CO) level and the
risk of pre-eclampsia (PE).
Pre-eclampsia, carbon
monoxide, cardiovascular
risk, population health,
epidemiology.
20052007
$35,604
$56,839
IV
Werstuck, Geoffrey
H; Capretta, Alfredo
McMaster
University
Investigating the role of GSK3 in
atherogenesis: rational design,
synthesis and screening of novel
GSK3 inhibitors as antiatherogenic therapies.
Atherosclerosis, glycogen
synthase kinase (GSK)-3,
inhibitors, diabetes mellitus,
hyperhomocysteinemia.
20052007
$72,931
$144,233
I
West, Lori J
Hospital for Sick
Children
Investigation of neonatal
immune tolerance induced by
the ABO-incompatible heart
transplantation in a murine
model.
Heart transplant, immune
tolerance, neonatal, ABO
antigens, molecular chimerism.
20042007
$103,713
$306,840
I
West, Lori J
Hospital for Sick
Children
Mechanisms of cardiac allograft
tolerance induced during
immaturity.
Tolerance, neonatal,
transplantation, heart graft,
rejection.
20032007
$89,045
$348,704
I
Whitman, Stewart C
University of
Ottawa Heart
Institute
The role of innate immune system in atherosclerosis: defining
the contribution of both natural
killer cells and natural killer T
cells to the disease process.
Atherosclerosis, LDLr -/- mice,
laser capture microdissection,
microarray analysis, histology.
20052008
$97,954
$293,892
I
Wisenberg, Gerald;
Prato, Frank S;
Merrifield, Peter A
London Health
Sciences Centre
Optimizing the administration
of marrow-derived stem cells to
repair left ventricular structure
and function in a canine model
of myocardial infarction.
Myocardial infarction, stem cell
delivery, magnetic resonance
imaging, positron emission
tomography, SPECT imaging.
20052007
$99,849
$198,879
I
Wittnich, Carin
University of
Toronto
Impact of gender and sex
hormones on myocardial
pathology & responses to
ischemia/reperfusion.
Gender, estrogen, testosterone,
progesterone, hypertrophy,
SERM, metabolism, function.
20042007
$86,197
$253,552
I
Yao, Zemin
University of
Ottawa Heart
Institute
Functional analysis of apoB
R463W mutation associated
with human familial
hypobetalipoproteinemia.
Hypertriglyceridemia, apoCIII,
VLDL assembly, cell culture,
transgenic mice.
20042007
$69,927
$208,027
I
Yao, Zemin
University of
Ottawa Heart
Institute
Hepatic lipase and
hypoalphalipoproteinemia.
Hepatic lipase, cholesterol,
lipoproteins, recombinant DNA,
transgenesis.
20052007
$65,743
$130,208
I
Yeung, Rae SM
Hospital for Sick
Children
Towards a better understanding
of Kawasaki Disease.
Kawasaki Disease,
superantigens, peptides,
t-cells, pathogenesis.
20062008
$79,847
$160,565
I, II
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
06-07 $
Total $*
Theme
Thème
IV: Population Health
IV : Santé de la population
115
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal et
Institut du chercheur
Durée
06-07 $
Total $*
co-chercheur(s)
principal
Yusuf, Salim;
McQueen, Matthew
J; Anand, Sonia
S; Teo, Koon K;
Merchant, Anwar T
McMaster
University
The INTERHEART study.
Risk factors, myocardial
infarction, ethnicity.
20052008
$148,575
$354,548
IV
Zaidi, Syed, HE
University Health
Network
Roles of growth differentiation
factor 5 and bone
morphogenetic protein 4 in
cardiovascular diseases.
Myocardial infarct, smooth
muscle proliferation, growth
factor, angiogenesis, transgenic
mice, bone morphogenetic
protein signalling.
20062008
$80,040
$161,201
I
Zha, Xiaohui
Ottawa Health
Research Institute
ABCA1-mediated cholesterol
efflux and intracellular
cholesterol transport.
ABCA1, cholesterol, membrane,
fluorescent microscopy,
trafficking.
20052008
$69,317
$207,951
I
Zhang, Liang
Toronto Western
Hospital
Hippocampal hyperexcitability
in rats after prolonged postischemic survival: a model of
post-stroke epileptic seizures.
20052007
$66,008
$132,016
I
Theme
Thème
Quebec | Québec
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Agharazii, Mohsen
Hôtel-Dieu de
Québec
Determinants of progression of
human aortic stiffness in renal
failure: role of advanced
glycation end products, oxidative
stress, endotheline-1 and
inflammation.
Arterial stiffness, advanced
glycation end-products,
oxidative stress, inflammation,
renal failure.
20062009
$13,700
$13,700
I, II
Allen, Bruce G
Montreal Heart
Institute
Molecular pharmacology of
endothelin receptors in adult rat
ventricular myocytes.
Endothelin, receptor, G
protein, cardiac myocyte,
adult
20042007
$18,000
$60,500
I
Anand-Srivastava,
Madhu B
Université de
Montréal
Role of oxidative stress in
diabetes/hyperglycemia-induced
impaired G-protein signaling and
cell function/proliferation.
Diabetes, hyperglycemia,
oxidative stress, adenylyl
cyclase, G-protein, vascular
smooth muscle.
20042007
$13,700
$44,700
I
Arsenault, Marie;
Couet, Jacques;
Elkouri, Stephane;
Gaboury, Louis
Hôpital Laval
Cardiac adaptations to chronic
aortic regurgitation.
Aortic valve, regurgitation,
ventricular function,
echocardiography.
20052008
$18,000
$35,500
I, II
Bachelard, Hélène;
Larivière, Richard
Centre hospitalier
de l’Université
Laval
Role of endothelial NO in
vascular and metabolic
dysfunctions related to insulin
resistance.
Insulin resistance, endothelial
dysfunction, vascular
reactivity, regional blood flow,
in vivo gene transfer
20042007
$13,700
$44,700
I
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
116
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Barbier, Olivier
Université Laval
Inhibition of bilirubin
glucuronidation by
cholesterol-lowering drugs: a
novel mechanism for the
reduction of atherogenesis.
Bentourkia,
M’hamed MB;
de Kemp, Robert
A; Lecomte, Roger;
Gollob, Michael H;
DaSilva, Jean N;
Beanlands, Rob S
Université de
Sherbrooke
Quantitative molecular PET
imaging in mouse models of
heart disease.
Billette, Jacques
Université de
Montréal
Role of dual pathways in
rate-dependent AV nodal
responses.
Bkaily, Ghassan
Université de
Sherbrooke
Blanchet, Sophie
SB
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
20052008
$13,700
$26,700
I, IV
20062009
$13,700
$13,700
I
Electrophysiology, AV
node, dual pathways, supraventricular tachyarrhythmia
mechanisms.
20042007
$13,700
$44,700
I
Modulation of nuclear calcium
cycling by ET-1 in heart cells.
Nucleus, endothelin-1,
pharmacology, calcium heart.
20042007
$13,700
$44,700
I
Institut de réadaptation en déficience physique
de Québec
Rehabilitation of episodic
memory disorders in patients
with frontal stroke: impact on
cerebral organization and life
habits.
Neuropsychology, memory,
cognitive rehabilitation,
event-related potentials,
frontal stroke, life habits.
20052008
$13,700
$26,700
I, II,
IV
Blostein, Mark D
Lady Davis
Institute for
Medical Research
Physiology of gas6-Ax1
interactions in endothelial cells.
Ax1, gas6, endothelium,
apoptosis, gamma-carboxylation.
20062009
$13,700
$13,700
I
Bogaty, Peter;
Brophy, James M
Hôpital Laval
Evaluation of a novel multimarker approach (CRP and
P-selectin) to risk stratification in
acute coronary syndromes.
CRP, inflammation, adhesion
molecule, acute coronary
syndrome.
20052008
$13,700
$26,700
II
Boulay, Guylain
Université de
Sherbrooke
Rôles des canaux TRPCs dans
les cellules du systeme
cardiovasculaire.
TRPC, signalisation, calcium,
muscle lisse, biologie
moleculaire.
20062009
18 000 $
18 000 $
I
Bouvier, Michel
Université de
Montréal
Molecular mechanisms
controlling the signaling efficacy
and selectivity of dynamic G
protein-coupled receptor
signaling complexes.
Receptors, regulation, posttranslational modification,
signaling efficacy, G-proteins.
20062009
$18,000
$18,000
I
Brissette, Louise
Université
du Québec à
Montréal
Oxidized LDL metabolism.
Lipoprotein, oxidation,
cholesterol, SR-BI, CD36.
20062009
$18,000
$18,000
I
Brophy, James
M; Yusuf, Salim;
Rouleau, JeanLucien; Joseph,
Lawrence
McGill University
Beta-blockers in congestive heart Beta-blockers, meta-analysis,
failure (CHF): a meta-analysis
congestive heart failure,
based on individual patient data. individual patient data, subgroup analysis.
20052007
$18,000
$35,500
II, IV
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
Bilirubin, anti-oxidant,
atheroprotection,
glucuronidation,
cholesterol-lowering drugs.
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
117
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Calderone, Angelo
Montreal Heart
Institute
Cardinal, René
Carpentier, André
C
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
Neural stem cells and scar
remodelling.
Reparative fibrosis, myofibroblasts, ANP, sympathetic
system, transgenics.
20062009
$13,700
$13,700
I
Hôpital du SacréSubstrates of reentrant
Coeur de Montréal ventricular tachycardias in the
pathologic ventricle.
Ventricular tachycardia, myocardial ischemia, congestive heart
failure, multi-point mapping,
cellular electrophysiology,
antiarrhythmic drugs.
20052008
$18,000
$35,500
I
Université de
Sherbrooke
Intravascular lipolysis of
triglyceride-rich lipoproteins on
myocardial substrate selection in
nutritional rat models of insulin
resistance and type 2 diabetes.
Lipoprotein metabolism,
diabetes, insulin resistance,
myocardial metabolism,
positron emission tomography.
20042007
$18,000
$59,087
I
Chahine, Mohamed Hôpital Laval
Le canal sodique cardiaque et
son rôle dans la génèse des
troubles du rythme.
Canal sodique, Nav1.5, coeur,
arythmie, syndrome
de Brugada, fibrillation
ventriculaire, patch clamp.
20062009
18 000 $
18 000 $
I
Chalifour, Lorraine
E; Sebag, Oga
Sir Mortimer B.
Davis Jewish
General Hospital
The role of gender-dependent
differences in calcium
homeostasis protein expression
in dictating the response to
catecholamine stress.
Gender, calcium homeostasis
proteins, gene expression,
catecholamine, cardiac
physiology.
20062009
$18,000
$18,000
I
Chemtob, Sylvain
Hôpital SainteJustine
Mechanisms of hypercapniainduced retinal vasoobliteration:
implications in retinopathy of
prematurity.
Free radicals, nitric oxide,
retina, cell death,
thromboxane.
20042007
$13,700
$44,700
I
Claing, Audrey
Université de
Montréal
Regulation of G protein-coupled
receptor function by ARF6.
G protein-coupled
receptor, endothelial and
vascular smooth muscle cells,
small GTPases, endocytosis,
cell migration.
20062009
$13,700
$13,700
I
Couet, Jacques;
Arsenault, Marie
Institut de cardiologie de Québec
Aortic valve stenosis in small
animal models.
Heart valve diseases, aortic
stenosis, atherosclerosis,
metabolic syndrome, animal
models.
20062009
$13,700
$13,700
I
Couture, Réjean
Université de
Montréal
Kinin receptors in diabetes and
hypertension.
Neuropeptides, autonomic
nervous system, CNS,
diabetes, hypertension.
20062009
$13,700
$13,700
I
Ditto, Blaine;
Bacon, Simon L;
Arsenault, André;
Campbell, Tavis
McGill University
Blood pressure, pain sensitivity,
and silent ischemia.
Pain sensitivity, hypoalgesia,
blood pressure, hypertension,
silent ischemia.
20052008
$18,000
$35,500
I, II
Drolet, Benoit
Université Laval
The possible role of diabetes
in drug-induced cardiac
proarrhythmia.
Electrophysiology, diabetes,
patch-clamp, action
potentials, ECG,
QT-prolonging drugs.
20062009
$18,000
$18,000
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
118
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
Drolet, Guy;
Centre hospitalier
Mouginot, Didier M de l’Université
Laval
Opioid regulation of salt intake.
Neuroregulation, salt appetite,
opioid peptide, salt-sensitive
hypertension.
20042007
$13,700
$44,700
I
Eisenberg, Mark
J; Pilote, Louise;
Lawrence, Joseph;
O’Loughlin,
Jennifer; Paradis,
Gilles
Sir Mortimer B.
Davis Jewish
General Hospital
The ZESCA trial.
Smoking cessation,
epidemiology, clinical trials,
acute coronary syndrome.
20042007
$13,700
$44,700
II
Filep, Janos
Hôpital
MaisonneuveRosemont
Inhibition of C-reactive proteinmediated inflammation by
aspirin-triggered lipoxins.
C-reactive protein,
inflammation, leukocyte,
aspirin-triggered lipoxins,
acute coronary syndromes.
20062009
$13,700
$13,700
I
Fiset, Céline
Montreal Heart
Institute
Male-female differences in
cardiac repolarization: hormonal
regulation of cardiac K+ channel
expression.
Potassium channels,
electrophysiology, mouse
heart, gender difference,
sex steroid hormones.
20042007
$13,700
$44,700
I
Gallo-Payet,
Nicole; Payet,
Marcel-Daniel
Université de
Sherbrooke
Rôle de l’angiotensine II dans
les cellules glomérulees de la
glande surrénale. Implication de
l’environment cellulaire.
Récepteurs AT1, angiotensine
II, cellules glomérulées,
fibronectine, intégrines,
cytosquelette.
20042007
13 700 $
44 700 $
I
Genest, Jacques;
Marcil, Michel;
Rashid, Shirya
Royal Victoria
Hospital
HDL genetics: the molecular
cellular physiology of
cholesterol efflux defect not
caused by ABCA1 mutations.
Cholesterol, high density
lipoproteins, ATP binding
cassette AI (ABCA1),
apolipoprotein AI, cellular
cholesterol transport.
20062009
$18,000
$18,000
I, II
Giaid, Adel
Montreal General
Hospital
Cardiovascular significance of
urotensin-II system deletion and
overexpression.
Urotensin-II, heart failure,
atherosclerosis, transgenic
mice, knockout mice.
20052008
$13,700
$26,700
I
Glavinovic, Mladen
I
McGill University
Dynamics of catecholamine
release and release of vesicular
content in neuroendocrine cells.
Catecholamine secretion,
electrophysiology, parameter
estimation, molecular
dynamics, electro-osmotic and
nano-fluidic simulations.
20062009
$13,700
$13,700
I
Gobeil, Fernand
Université de
Sherbrooke
Novel localization of nuclear
kinin B2 receptors and functional
correlates.
20062009
$13,700
$13,700
I
Greenwood,
Michael T
McGill University
Functional analysis of the cardiac
and skeletal muscle specific
RGS5.
Signal transduction, G protein
coupled receptors, molecular
cardiology, yeast genetics,
mutagenesis, regulators of
G-protein signalling (RGS).
20042007
$13,700
$44,700
I
Guillemette,
Gaétan
Université de
Sherbrooke
Propriétés moléculaires et
fonctionnelles des récepteurs
de l’inositol 1,4,5-trisphosphate
dans l’endothélium.
Endothélium, récepteur de
l’inositol 1,4,5-trisphosphate,
calcium phosphorylation,
signalisation intracellulaire.
20052008
18 000 $
35 500 $
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
119
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Gutkowska,
Jolanta; Jankowski,
Marek; Coderre,
Lise
Centre hospitalier
de l’Université de
Montréal
Role of the insulin regulated
aminopeptidase (oxytocinase) in
the heart.
Insulin regulated
aminopeptidase, insulin
action, pregnancy, natriuretic
peptides.
20062009
$18,000
$18,000
I
Hébert, Terence E
McGill University
Composition, ontogeny and
biosynthesis of specific GPCR
signaling complexes.
Signaling, G proteins,
organization, heart failure,
adrenergic receptors.
20052008
$13,700
$26,700
I
Hussain, Sabah NA
Royal Victoria
Hospital
Role of NADPH oxidase in
signalling and biological effects
of the angiopoietin-1/tie-2
pathway in endothelial cells.
Angiogenesis, apoptosis,
oxygen radicals, NADPH
oxidase, endothelial cells.
20052008
$13,700
$26,700
I
Jacques, Danielle
Université de
Sherbrooke
Regulation of cytosolic and
nuclear calcium by angiotensin II
in endocardial endothelial cells.
Angiotensin II, receptors,
intracellular calcium, confocal
microscopy, receptor
mapping.
20042007
$13,700
$44,700
I
Jolicoeur, Paul
Clinical Research
Institute of
Montreal
Studies of cardiac disease in
CD4C/HIV transgenic mice.
20052008
$13,700
$26,700
I
Jones, Peter JH
McGill University
Effects of plant sterol supplemen- Phytosterols, exercise,
tation and exercise training
cholesterol, cholesterol
cholesterol kinetics and cardiometabolism, LDL particle size.
vascular disease risk parameters
in previously sedentary adults.
20042007
$13,700
$44,700
II
Julien, Pierre;
Fraser, William D
Centre hospitalier
de l’Université
Laval
Dyslipoproteinemia and oxidative stress in preeclampsia; a risk
factor for endothelial dysfunction
and vascular diseases.
20042007
$13,700
$44,700
I
Kahn, Susan R;
Wells, Philip S;
Anderson, David
R; Genest, Jr,
Jacques; Kovacs,
Michael J; Rodger,
Marc A; Shapiro,
Stanley H
Sir Mortimer B.
Davis Jewish
General Hospital
The role of inflammation
and thrombophilia in the
post-thrombotic syndrome:
the bio-sox study.
Post-thrombotic syndrome,
predictors, thrombophilia,
SNP analysis, inflammation,
D-dimer.
20052008
$14,614
$28,803
II
Lamontagne,
Anouk; Fung,
Joyce; McFadyen,
Bradford J;
Faubert, Jocelyn
McGill University
Visuomotor control of
locomotion after stroke.
Rehabilitation, locomotion,
virtual reality, motor control,
vision.
20052008
$13,700
$26,700
I, II
Lamontagne,
Daniel
Université de
Montréal
Cardioprotective properties of
the endogenous cannabinoid
system.
Myocardial infarction,
cannabinoids, cytokines,
nuclear receptor PPAR.
20052008
$13,700
$26,700
I
Lanfranchi, Paola
A; Montplaisir,
Jacques Y
Hôpital du SacréCardiovascular autonomic
Coeur de Montréal regulation during sleep and
wakefulness in primary insomnia.
Insomnia, sleep, autonomic
nervous system, blood
pressure.
20052008
$13,700
$26,700
II
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
120
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Larivière, Richard
Hôtel-Dieu de
Québec
Role of TGF-beta 1 in vascular
endothelial dysfunction.
Hypertension, renal failure,
endothelium, blood vessels,
vasoactive factors.
20062009
$13,700
$13,700
I
Lavoie, Julie L
Centre hospitalier
de l’Université de
Montréal
Role of tissue-specific
renin-angiotensin system in
adipose tissue in obesity and
obesity-related hypertension.
Obesity, obesity-related
hypertension, reninangiotensin system, adipose
tissue.
20062008
$18,000
$18,000
I
Leduc, Richard;
Lavigne, Pierre;
Escher, Emmanuel;
Klarskov, Klaus
Université de
Sherbrooke
Molecular mechanisms of
urotensin II.
20062009
$13,700
$13,700
I
Lerouge, Sophie;
Soulez, Gilles;
Gaboury, Louis;
Elkouri, Stephane
Université de
Montréal
Healing and endoleaks following
endovascular repair of abdominal aortic aneurysms: an analysis
of explanted stent-grafts.
Aneurysms, endovascular
treatment, healing process,
stent-graft, explants.
20052007
$13,700
$26,700
I
Lesur, Olivier;
Lecomte, Roger;
Bentourkia,
M’hamed MB
Université de
Sherbrooke
Impact of fluid resuscitation
on endotoxin-induced heart
dysfunction.
Septic shock, myocardial
dysfunction, PET scan imaging,
myocardial apoptosis, fluid
resuscitation.
20062009
$18,000
$18,000
I
Magder, Sheldon A
McGill University
Role of vascular vs phagocytic
NAD(P)H oxidase in the septic
response.
Sepsis, reactive oxygen
species, microcirculation
inflammation, lung injury,
NFkB.
20062009
$18,000
$18,000
I
Merhi, Yahye
Institut de cardiologie de Montréal
Thrombo-inflammatory roles of
platelet P-selectin/PSGL-1
interactions.
Adhesion molecules,
neutrophils, platelets,
endothelium, restenosis.
20052008
$18,000
$35,500
I
Miller, Sydney B;
Fellows, Lesley
K; Mayo, Nancy;
Koski, Lisa; Ludson,
Ronald; Gagnon,
Bruno
Concordia
University
Tracking the dynamics of
depression in older persons
with stroke.
Stroke, depression,
assessment, lesion, cognitive.
20062008
$13,700
$13,700 I, II, III
Moreau, Pierre
Université de
Montréal
Mechanisms of mineral loss in
medial elastocalcinosis (medial
arterial calcification): a therapeutic
opportunity for isolated systolic
hypertension.
Endothelin, elastocalcinosis,
aortic stiffness, extracellular
matrix.
20062009
$18,000
$18,000
I
Mounier, Catherine
Université
du Québec à
Montréal
Hormonal regulation of stearyl
Stearyl CoA desaturase,
CoA desaturase gene: importance insulin, leptin, liver, obesity.
of obesity and diabetes.
20042007
$13,700
$44,700
I
MukaddamDaher, Suhayla;
Gutkowska, Jolanta
Centre hospitalier
de l’Université de
Montréal
Cardiac effects of chronic
imidazoline receptor activation
in heart failure.
20052008
$13,700
$26,700
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
$ cumulatif
reçu en 2007
II: Clinical
II : Clinique
Heart failure, imidazoline
receptors, moxonidine,
natriuretic peptides, cytokines,
apoptosis.
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
121
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Nattel, Stanley
Montreal Heart
Institute
Factors influencing the
interaction of antiarrhythmic
drugs with cardiac tissues.
Sudden death, ventricular
tachycardia, ion channels,
remodeling, molecular
biology.
20042007
$18,000
$60,500
I
Noiseux, Nicolas
Centre hospitalier
de l’Université de
Montréal
Angiogenic and paracrine effects
of bone marrow-derived
mesenchymal stem cells for
the treatment of myocardial
infarction.
Adult stem cells, myocardial
infarction, cardiac repair,
angiogenesis, paracrine.
20062009
$13,700
$13,700
I
Nuyt, Anne
Monique
Hôpital SainteJustine
Role of oxidative stress in fetal
programming of hypertension.
Hypertension, programming,
oxidant, vascular, brain.
20042007
$13,700
$44,700
I
Orlov, Sergei N;
Tremblay, Johanne;
Hamet, Pavel
Centre hospitalier
de l’Université de
Montréal
Cloning and functional
characterization of Na+/Li+
countertransporter.
Na+/Li+ countertransport,
Na+/H+ exchange, cloning,
proteomics, hypertension.
20042007
$13,700
$44,700
I
Parent, Lucie
Université de
Montréal
Molecular determinants of gating Calcium, ion channel,
in voltage-gated Ca channels.
electrophysiology, regulation,
scaffolding proteins.
20052008
$18,000
$35,500
I
Pausova, Zdenka;
Gaudet, Daniel;
Leal, Suzanne M
Centre hospitalier
de l’Université de
Montréal
Long term cardiovascular and
metabolic consequences of
prenatal exposure to maternal
cigarette smoking in French
Canadian adolescents.
20052008
$13,700
$26,700
I, II,
IV
Perrault, Louis P
Montreal Heart
Institute
Mechanisms of pulmonary
arterial endothelial dysfunction
following cardiopulmonary bypass
in cardiac surgery: impacts on
hemodynamics, oxygenation and
development of preventive and
therapeutic strategies.
20052008
$13,700
$26,700
I, II,
III, IV
Pharand, Chantal;
Diodati, Jean G;
Amyot, Robert
Hôpital du SacréDeterminants of subendocardial Subendocardial ischemia,
Coeur de Montréal ischemia at normal heart rate in a myocardial perfusion,
porcine model.
myocardial contrast
echocardiography, platelet
mediators.
20062009
$13,700
$13,700
I
Pibarot, Philippe;
Dumesnil, Jean
G; Després, JeanPierre; Mathieu,
Patrick
Université Laval
Metabolic determinants of the
progression of aortic stenosis.
20062009
$18,000
$18,000
I, II
Powell, William S
McGill University
Eicosanoids and leukocyte and
endothelial cell function.
20062009
$18,000
$18,000
I
Raymond, Jean
Centre hospitalier
de l’Université de
Montréal
Inhibition of recanalization after
coil embolization of intracranial
aneurysms with endothelial
denudation and in situ beta
radiation.
20052008
$13,700
$26,700
I
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
122
Metabolic syndrome,
adolescence, fetal
programming, maternal
cigarette.
Valvular heart disease,
aortic stenosis, metabolism,
metabolic syndrome,
doppler-echocardiography.
Brain aneurysm, recurrence,
endothelial denudation, beta
radiation, animal models of
human disease.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Richard, Darren E
Hôtel-Dieu de
Québec
Rousseau, Guy
Hôpital du SacréPost-ischemic cardioprotection
Coeur de Montréal by A2A adenosine receptors.
Sauvé, Remy
Université de
Montréal
Molecular studies of IKCa gating
in endothelial cells.
Servant, Marc
Université de
Montréal
Roles of interferon regulatory
factor-3 and NF-kB transcription
factors in the induction of
pro-atherosclerotic conditions by
classical as well as emerging risk
factors.
Shrier, Alvin; Glass,
Leon
McGill University
Sirois, Martin G
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
Vascular smooth muscle,
angiogenesis, hypoxia, HIF,
angiotensin.
20052008
$18,000
$35,500
I
Myocardial, reperfusion,
infarction, adenosine,
signalisation.
20042007
$13,700
$44,700
I
20052008
$18,000
$35,500
I
Inflammation, angiotensin II,
pathogens, NF-kB,
interferon-regulatory factors,
signal transduction
mechanisms.
20062009
$13,700
$13,700
I
Dynamics and remodeling of
cultured cardiac cells.
Tissue culture, optical
mapping, cardiac
electrophysiology, nonlinear
mathematics, pacing.
20062009
$13,700
$13,700
I
Montreal Heart
Institute
Agonistic activities of
angiopoietins on neutrophils.
Angiopoietins, Tie2 receptor,
neutrophils, cell signaling,
inflammation.
20062009
$18,000
$18,000
I
St Louis, Jean
Hôpital SainteJustine
Régulation de la circulation
placentaire par les prostanoides,
comparaison de la grossesse
normale et la prééclampsie.
Placenta, prééclampsie,
vaisseaux sanguins,
soprostanes, prostaglandines.
20042007
13 700 $
44 700 $
I
St-Amand, Jonny;
Raymond, Vincent
Université Laval
Effects of high-fat meal on
transcriptomes and
characterization of novel
appetite-satiety genes.
Obesity, coronary artery
disease, functional genomics,
gene discoveries, high fat diet.
20052008
$13,700
$26,700
I, II,
III, IV
Stochaj, Ursula
McGill University
Protein trafficking in stressed
cells.
Nuclear transport, heat shock
proteins, hsp/hsc70s, oxidative
stress, ischemia/reperfusion.
20042007
$18,000
$60,500
I
Tanguay, JeanFrançois
Montreal Heart
Institute
Role of estrogens and estrogen
receptors (ER alpha and ER beta)
in vascular healing.
Estrogen, estrogen receptors,
atherosclerosis, restenosis,
acute coronary syndromes.
20042007
$13,700
$44,700
I
Thibault, Gaétan
Institut de
recherches
cliniques de
Montréal
Hétérogénéité des fibroblastes
cardiaques.
Cardiac fibroblasts, fibrosis,
inflammation, Thy-1 protein,
CD40.
20052008
13 700 $
26 700 $
I
Thorin, Eric;
Ferland, Guylaine;
Hamel, Edith
Montreal Heart
Institute
Mechanisms and cognitive
consequences of cerebrovascular
dysfunction in aging and
dyslipidemia.
Cerebrovascular dysfunction,
aging, dyslipidemia, cerebral
blood flow, cognitive
impairment.
20062009
$13,700
$13,700
I
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
Vasoactive hormones and
hypoxia in the control of vascular
hypoxic genes.
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
123
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal
Institut du chercheur
et co-chercheur(s)
principal
Tremblay, Angelo;
Després, JeanPierre; Richard,
Denis; Lamarche,
Benoit; Blundell,
John
Université Laval
Clinical evaluation to improve
obesity intervention prescription:
functional foods as a potential
solution for low satiety quotient
phenotype?
Turgeon, Jacques
Université de
Montréal
Drug-induced long QT
syndrome: the modulatory role
of P-glycoprotein (MDR1).
Wang, Zhiguo
Montreal Heart
Institute
Kr/HERG K+ channel as a critical
molecular contributor to
electrical disorders during acute
myocardial ischemia: extracellular
K+ accumulation and “Short QT
Syndrome”.
White, Michel;
Touyz, Rhian M
Montreal Heart
Institute
Wu, Jiangping
Centre hospitalier
de l’Université de
Montréal
06-07 $
Cumulative $
Theme
to 2007
Thème
$ cumulatif
reçu en 2007
20042007
$13,700
$44,700
II
Electrophysiology,
antiarrhythmics, proarrhythmia,
p-glycoproteins,
drug-interactions.
20052008
$18,000
$35,500
I
Myocardial ischemia,
potassium, arrhythmias, IKr/
HERG, LPC.
20052008
$13,700
$26,700
I
Inflammation, oxidative stress,
and exercise capacity and
recovery in congestive heart
failure and in chronic obstructive
pulmonary disease.
20052008
$13,700
$26,700
I, II,
IV
Immune regulation in heart trans- Transplantation, death decoy
plantation.
receptor 3, T cell migration.
20052008
$18,000
$35,500
I
06-07 $
New Brunswick | Nouveau-Brunswick
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal
Institut du chercheur
Durée
et co-chercheur(s)
principal
Cheema, Sukhinder Memorial
K
University of
Newfoundland
Mechanisms of regulation of
triacylglycerol and cholesterol
metabolism by dietary lipids.
Atherosclerosis, fish oil, lipoprotein lipase, transcription
factors, oxidative stress.
20062007
$40,000
$40,000
I
Chen, Robert PC
IWK Health Centre
Remodelling of the intrinsic
cardiac nervous system by left to
right cardiac shunts.
Intrinsic cardiac neuron, shunt,
stent, ductus arteriosus,
congenital heart disease.
20062009
$47,000
$141,000
I
Currie, R William
Dalhousie
University
Heat shock proteins and
cardiovascular protection.
Heat shock proteins, blood
vessels, inflammation, heart,
brain.
20062009
$47,000
$141,000
I
Legare, JeanFrancois
Dalhousie
University
Kinetics of neutrophil trafficking
in post ischemic myocardium.
Neutrophil, inflammation,
myocardial infarction, cell
adhesion, chemokines.
20062009
$47,000
$141,000
I
McDonald, Terence
F
Dalhousie
University
ATP-sensitive K+ channels in
heart cells.
Ventricular myocytes,
voltage-clamp, K-ATP
channels, regulation,
site-directed mutagenesis.
20042007
$72,160
$172,160
I
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
124
Total $*
Theme
Thème
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Chercheur principal
Institut du chercheur
Durée
06-07 $
Total $*
et co-chercheur(s)
principal
Ridgway, Neale D
Dalhousie
University
Functional analysis of the role of
two oxysterol binding proteins in
lipid homestasis.
Cholesterol, oxysterols, lipid
transport, protein-protein
interactions.
20052008
$50,000
$150,000
I
Schlichter, Lyanne
C; Peeling, James;
Corbett, Dale R
Toronto Western
Research Institute
Targeting K channels to control
inflammation in stroke.
Intracerebral hemorrhage,
focal ischemia, retinal ischemia, optic nerve transection,
potassium channels, CNS
inflammation, immune-cell
activation.
20052008
$46,000
$138,000
I
Theme
Thème
Nova Scotia | Nouvelle-Écosse
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Easton, Alexander S
Dalhousie
University
An investigation of the role played
by free radicals and calcium in
neutrophil dependent alterations in
permeability across the blood-brain
barrier.
Blood-brain barrier,
neutrophil, permeability,
calcium, free radical.
20042007
$47,000
$141,000
I
Eskes, Gail A; Klein,
Ray
Dalhousie
University
Rehabilitation of attention in
hemi-spatial neglect.
Hemi-spatial neglect,
rehabilitation, stroke,
neuropsychology, attention.
20042007
$47,053
$142,800
II
Gardner, Martin J;
Horacek, B Milan
Dalhousie
University
Electrocardiographic characteristics
of arrhythmogenic right ventricular
cardiomyopathy.
Cardiac clinical
electrophysiology,
biomedical engineering.
20062009
$44,000
$44,000
I, II
Howlett, Susan E;
Ferrier, Gregory R
Dalhousie
University
Ischemic preconditioning in
ventricular myocytes from young
adult and aged animals.
Aging, ischemia and
reperfusion, ischemic
preconditioning, arrhythmias, ventricular myocyte.
20062009
$47,000
$47,000
I
MacRae, Thomas H
Dalhousie
University
Structural and functional characterization of small heat shock proteins:
molecular chaperone activity during
physiological stress.
Molecular chaperones, small
heat shock proteins, physiological stress, ischemia/
reperfusion injury, heart.
20052008
$50,000
$100,000
I
Marsh, Daniel R
Dalhousie
University
Spared bulbospinal axons can
prevent autonomic dysreflexia from
developing after spinal cord injury.
Spinal cord, episodic
hypertension, autonomic
dysreflexia, sympathetic
preganglionic neuron,
ventral lateral medulla.
20042007
$44,000
$132,000
I
Parkash, Ratika;
Sapp, John L; Basta,
Magdy N; Gardner,
Martin J; Tang,
Anthony SL; Wells,
George A
Dalhousie
University
Abnormalities in rhythm in the
cardiac resynchronization/
defibrillation in advanced heart
failure trial.
Heart failure, implantable
defibrillator, cardiac
resynchronization, ventricular
arrhythmias, sudden death.
20062009
$50,000
$50,000
I, II,
III, IV
Themes I: Basic Biomedical
Thèmes I : Biomédicale fondamentale
$ cumulatif
reçu en 2007
II: Clinical
II : Clinique
III: Health Services/Systems
III : Services et systèmes de santé
IV: Population Health
IV : Santé de la population
125
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
06-07 $
Cumulative $
Theme
to 2007
Thème
Principal Investigator
Institute of Principal
Project
Keywords
Term
and Co-Investigator(s)
Investigator
Projet
Mots-clés
Durée
Chercheur principal et
Institut du chercheur
co-chercheur(s)
principal
Pasumarthi, Kishore
Babu S
Dalhousie
University
Regulation of cardiomyocyte cell
cycle by D-type cyclins.
Cardiomyocyte cell cycle,
myocardial repair, gene
transfer, transgenic mice,
protein-protein interactions.
20042007
$50,000
$150,000
I
Robertson, Harold
A; Currie, R William
Dalhousie
University
Stroke genomics identification of
the temporal and spatial patterns of
gene expression in the early hours
following cerebral ischemia.
Stroke, DNA microarray,
gene expression profiling,
neuroprotection.
20042007
$50,000
$150,000
I
Sapp, John L;
Horacek, B Milan
Queen Elizabeth
II Health Sciences
Centre
Electrocardiographic mapping to aid
ablation of scar-related ventricular
tachycardia.
Clinical cardiac
electrophysiology,
biomedical engineering.
20042007
$47,623
$143,835
II
$ cumulatif
reçu en 2007
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
126
APPENDIX
Annexe
D
RESEARCH CHAIRS AND PROFESSORSHIPS
CHAIRES DE RECHERCHE ET POSTES DE PROFESSEURS
In 2006-2007 Dr. Henry Duff (University of Calgary) was the Heart and Stroke Foundation of Alberta, NWT & Nunavut Chair in Cardiovascular Research.
Photo by: Trudie Lee
En 2006-2007, Dr Henry Duff (Université de Calgary) était titulaire de la Chaire de recherche cardiovasculaire de la Fondation des maladies du cœur de
l’Alberta, des T.-N.-O. et du Nunavut.
Photo par : Trudie Lee
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Research Chairs and Professorships | Chaires de recherche et postes de professeurs
Research Chairs
Type
Foundation
2006/2007 Value
Chaires de recherche
Type
Fondation
Montant 2006-2007
Dr. Christopher Buller, University of British Columbia
Cardiology/Cardiologie
HSFBCY/FMCCB et Y
$160,000
Dr. Yu Tian Wang, University of British Columbia
Stroke/AVC
HSFBCY/FMCCB et Y
$110,000
Dr. Henry Duff, University of Calgary
Cardiology/Cardiologie
HSFA/FMCA
$173,462
Dr. Heather Arthur, McMaster University
Cardiac Nursing/Soins infirmiers en cardiologie
HSFO/FMCO
$102,489
Dr. Fred Keeley, Hospital for Sick Children
Cardiology/Cardiologie
HSFO/FMCO
$138,777
Dr. Peter Liu, Toronto Hospital/University of Toronto
Cardiology/Cardiologie
HSFO/FMCO
$77,450
Dr. Brian Rutt, Robarts Research Institute
Cardiology/Cardiologie
HSFO/FMCO
$159,046
Dr. Jeffery Weitz, Hamilton Civic Hospitals Research Centre
Cardiology/Cardiologie
HSFO/FMCO
$77,811
Dr. Salim Yusuf, McMaster University
Cardiology/Cardiologie
HSFO/FMCO
$74,545
Professorships
Type
Foundation
Postes de professeurs
Type
Fondation
Dr. Philip Teal, University of British Columbia
Stroke/AVC
HSFBCY/FMCCB et Y
$70,000
Dr. Ken Butcher, University of Alberta
Stroke/AVC
HSFA/FMCA
$80,000
Dr. Micheal Hill, University of Calgary
Stroke/AVC
HSFA/FMCA
$80,000
Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from
other sources.
Généralement, les chaires de recherche et les postes de professeurs sont financés par la contribution des fondations provinciales mentionnées ainsi
que par des sommes provenant d’autres sources.
128
APPENDIX
Annexe
E
OTHER PROVINCIAL INITIATIVES
AUTRES INITIATIVES PROVINCIALES
The Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source is a powerful new tool for the imaging, study and treatment of
disease. This facility is funded through a broad-based partnership of supporters, including the Heart and Stroke Foundation of Saskatchewan.
Photo by: Canadian Light Source Inc., University of Saskatchewan.
Le faisceau d’imagerie et de traitement biomédical du Centre canadien de rayonnement synchrotron est un puissant outil d’imagerie, d’étude et
de traitement des maladies. Ces installations sont financées par un vaste partenariat de supporteurs, dont la Fondation des maladies du cœur de la
Saskatchewan.
Photo par le Centre canadien de rayonnement synchrotron inc., Université de la Saskatchewan.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
British Columbia/Yukon
Colombie-Britannique / Yukon
Special Initiative: CardioSHARE - Cardiovascular Semantic
Health and Research Environment
Principal Investigators: Dr. Bruce McManus and
Dr. Mark Wilkinson
Providence Heart + Lung Institute
$360,000 over 2 years (March 1, 2007 to Feb. 28, 2009) to develop
a data search, classification, and management system for
ischemic heart disease.
Initiative spéciale : CardioSHARE - Environnement de santé et
de recherche cardiovasculaires sémantiques
Chercheurs principaux : Dr Bruce McManus et Dr Mark Wilkinson
Institut Providence Heart + Lung
360 000 dollars sur deux ans (1er mars 2007 au 28 février 2009)
afin de développer un système de recherche, de classification
et de gestion des données sur les maladies cardiovasculaires
ischémiques.
Alberta/Northwest Territories/Nunavut
Alberta / Territoires du Nord-Ouest /
Nunavut
Young Investigator Travel Awards | Bourses de déplacement pour jeune chercheur
Awardee
Institute of
Project
Keywords
Term
Récipiendaire
Institut
Projet
Mots-clés
Durée
Davidge, Sandra T
University of
Alberta
Preeclampsia: circulating factors
and endothelial cell dysfunction.
Preeclampsia, endothelium, oxidative stress,
nitric oxide, matrix, metalloproteinase.
20062007
$5,000
$5,000
Seubert, John M
University of
Alberta
Role of eicosanoids in heart function Eicosanoids, cytochrome P450 epoxygenases,
and injury.
ischemia-reperfusion injury, potassium
channels, natriuretic peptides.
20062007
$5,000
$5,000
Tyberg, John V
University of
Calgary
New hemodynamic approaches to
the pulmonary circulation.
Windkessel, wave intensity analysis,
pulmonary hemodynamics, pulmonary
hypertension, doppler echocardiography.
20062007
$5,000
$5,000
Waisman, David M
University of
Calgary
Regulation of fibrinolysis by annexin
II tetramer.
Annexin, antiphospholipid syndrome,
plasmin, plasminogen, endotheliium.
20062007
$5,000
$5,000
Saskatchewan
Biomedical Imaging and Therapy (BMIT) Beamline at the
Canadian Light Source
HSFS annual commitment is $100,000 for five years from 2005 to
2009.
Manitoba
R.E. Beamish Award
An award of excellence in cardiac research given to the highest
rated HSFM GIA recipient in honour of Dr. Robert Beamish.
2006-2007 Recipient:
Dr. Marc Del Bigio (University of Manitoba) $10,000
130
06-07 $ Total $*
Saskatchewan
Le faisceau d’imagerie et de traitement biomédical du Centre
canadien de rayonnement synchrotron
L’engagement annuel de 100 000 $ de la FMCS pour une durée
de cinq ans, soit de 2005 à 2009.
Manitoba
Prix R.E. Beamish
Prix d’excellence en recherche cardiovasculaire remis au lauréat
de subvention de la FMCM ayant obtenu la plus haute note, en
hommage au Dr Robert Beamish.
Lauréat 2006-2007
Dr Marc Del Bigio (Université du Manitoba) 10 000 $
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Ontario | Ontario
Group/Program Grants | Subventions de groupe et de programme
Principal
Institute of Principal
Project
Co-Investigator(s)
Term
Projet
Co-chercheur(s)
Durée
06-07 $
Total $*
$500,000
Investigator
Investigator
Chercheur
Institut du
principal
chercheur principal
Floras, John S
Mount Sinai Hospital
Multidisciplinary group for the
investigation and therapy of
human cardiovascular disease.
Newton, Gary E; Parker, John D;
Bradley, T Douglas; Chauhan, Vijay S
20032008
$100,000
Huff, Murray W
Robarts Research
Institute
Cellular programs and
responses in atherosclerosis.
Ferguson, Stephen G; Hegele, Robert
A; Pickering, J Geoffrey
20062011
$250,000 $1,250,000
Karmazyn, Morris
University of Western
Ontario
A multidisciplinary, integrative
approach towards the study of
heart failure.
Chakrabarti, Subrata; Chidiac, Peter;
Feng, Qingping; Jones, Douglas L;
Narayanan, Njanoor; Sims, Stephen M
20022007
$240,000 $1,200,000
Langille, B Lowell
Toronto General
Hospital
Cell biology of atherosclerosis. Bendeck, Michelle P; Courtman, David
W; Cybulsky, Myron I; Gotlieb, Avrum
I; Husain, Mansoor; Marsden, Philip A;
Stewart, Duncan J; Strauss, Bradley H;
Ward, Michael E; Heximer, Scott P
20052010
$250,000 $1,249,915
Leenen, Frans HH
University of Ottawa
Heart Institute
Molecular and genetic bases
for coronary artery disease
and the progression to heart
failure.
O’Brien, Edward R; Tesson, Frederique;
Tuana, Balwant S; Whitman, Stewart C
20032008
$150,000
Wells, Philip S
University of Ottawa
Thrombophilia: from bench to
bedside to health economics
and policy.
Rodger, Marc A; Walker, Mark; Gagnon,
France
20042009
$250,000 $1,250,000
$750,000
Health Behaviour Research Initiative | Initiative de la recherche sur la santé et les habitudes de vie
Principal
Institute of Principal
Investigator
Investigator
Chercheur
Institut du
principal
chercheur principal
Allison, Kenneth
R
University of Toronto
Project
Co-Investigator(s)
Term
Projet
Co-chercheur(s)
Durée
Physical activity promotion
among youth.
Goodman, Jack M; Adlaf, Edward
M; Dwyer, John JM
20012007
06-07 $
Total $*
$209,242
$1,081,184
131
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Stroke Rehabilitation | Réadaptation après un AVC
Principal
Institute of Principal
Project
Co-Investigator(s)
Term
Investigator
Investigator
Projet
Co-chercheur(s)
Durée
Chercheur
Institut du
principal
chercheur principal
Brooks, Dina
University of Toronto
Cardic rehabilitation after stroke.
Black, Sandra E; McIlroy, William
E; Sahlas, Demetrios James; Oh,
Paul; Bayley, Mark T; Richardson,
Denyse L
20062009
$73,940
$208,276
Brouwer, Brenda
Queen’s University
Client-centred ‘tune-ups’: Do
they enhance physical capacity,
mobility function and community
reintegration in stroke survivors?
Garland, S Jayne; Bryant, Dianne M;
Connelly, Denise M; Maly, Monica
R; Minnes, Patricia M; MacIntyre,
Norma J; Pelland, Lucie C
20062009
$227,473
$680,736
Huijbregts, Maria
PJ
Baycrest Centre for
Geriatric Care
Filling the community programStreiner, David L; Cameron, Jill
ming gap in northern Ontario:
I; Taylor, Denise M; Kagan, Aura;
Telehealth dissemination of a stroke McEwen, Sara
self-management program.
20052008
$161,945
$407,595
Popovic, Milos R
University of Toronto
Functional electrical
stimulation-assisted walking:
enhancement of voluntary
walking function among persons
with severe hemiplegia post stroke.
20062008
$177,681
$309,946
Salbach, Nancy M; Thabane,
Lehana; Verrier, Mary C; Richardson,
Denyse L; Giangregorio, Lora M
06-07 $
Total $*
Age 45+ with Elevated Systolic Blood Pressure | Tension artérielle systolique élevée chez les 45 ans et plus
Principal
Institute of Principal
Project
Co-Investigator(s)
Term
Projet
Co-chercheur(s)
Durée
06-07 $
Total $*
Investigator
Investigator
Chercheur
Institut du
principal
chercheur principal
Fayad, Ashraf A
University of Ottawa
Peri-operative myocardial
ischemia in isolated systolic
hypertension (PROMISE).
Ruddy, Terrence D; Yang, Homer;
Wells, George A; Watters, James M
20062008
$177,203
$359,928
Logan, Alexander
G
Mount Sinai Hospital
Self-monitoring of blood pressure
in primary care in older (45+ years)
diabetic patients with uncontrolled systolic hypertension.
Irvine, Jane M; McIsaac, Warren
J; Feig, Denice; Easty, Anthony C;
Cafazzo, Joseph A; Rossos, Peter
G; Davis-Halifax, Nancy; Kelly,
Catherine M; Parkes, Robert K
20062009
$205,320
$629,619
Myers, Martin G
Sunnybrook Health
Sciences Centre
Automated office blood pressure
measurement.
Tobe, Sheldon W; Kaczorowski,
Janusz; Godwin, Marshall S; Kiss,
Alexander J; Dawes, Martin
20052009
$374,792 $1,507,534
Heart and Stroke/Richard Lewar Centre of Excellence in
Cardiovascular Research
Interim Director: Dr. Mansoor Husain,
University of Toronto
HSFO contribution: $6 million
This research investment represents commitments from
previous funding years involving research activity that carries
into 2006/2007.
132
Centre d’excellence en recherche cardiovasculaire Heart
and Stroke/Richard Lewar
Directeur par intérim : Dr Mansoor Husain,
Université de Toronto
Contribution de la FMCO : 6 million $
L’investissement en recherche représente des engagements pris
au cours d’exercices précédents envers un projet de recherche
qui se poursuit en 2006-2007.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Heart and Stroke Foundation Centre for Stroke Recovery
Co-directors:
Dr. Antoine M. Hakim, Ottawa Health Research Institute
Dr. Sandra Black, Sunnybrook and Women’s College Health
Science Centre
Dr. Don Stuss, Baycrest Centre for Geriatric Care
HSFO annual commitment of $649,000 for ten years from 2002 to
2011, plus $997,000 capital campaign contribution in 2006/2007.
Centre de réadaptation d’AVC de la Fondation des maladies
du cœur
Co-directeurs :
Dr Antoine M. Hakim, Institut de recherche en santé d’Ottawa
Dre Sandra Black, Sunnybrook and Women’s College Health
Science Centre
Dr Don Stuss, Baycrest Centre for Geriatric Care
Engagement annuel de 649 000 dollars sur 10 ans de la FMCO,
de 2002 à 2011, plus une contribution de 997 000 dollars de
capitalisation en 2006-2007.
Quebec
Québec
Awards for excellence
Awards for excellence highlighting the outstanding contribution
of researchers.
Prix d’excellence
Prix d’excellence mettant en lumière la contribution remarquable
des chercheurs.
These awards enhance the grants allocated to these researchers
in 2006-2007:
Ces prix viennent bonifier la subvention accordée à ces
chercheurs en 2006-2007 :
The 4th International Conference on Preventive Cardiology Award
Dr. Philippe Pibarot (Hôpital Laval) $20,000
Le prix de la 4e Conférence internationale de cardiologie préventive
Dr Philippe Pibarot (Hôpital Laval) 20 000 $
The Jonathan Ballon Award
Dr. Mohsen Agharazii (Hôtel-Dieu de Québec) $10,000
Le prix Jonathan Ballon
Dr Mohsen Agharazii (Hôtel-Dieu de Québec) 10 000 $
The John J. Day Award
Dr. William S. Powell (McGill University) $10,000
Le prix John J. Day
Dr William S. Powell (Université McGill) 10 000 $
The RBC Royal Bank Award
Dr. Sydney B. Miller (Concordia University) $10,000
Le prix RBC Banque Royale
Dr Sydney B. Miller (Université Concordia) 10 000 $
The Desjardins Financial Security Award
Dr. Lorraine E. Chalifour (Sir Mortimer B. Davis - Jewish General
Hospital) $10,000
Le prix Desjardins Sécurité financière
Dre Lorraine E. Chalifour (Hôpital général juif Sir Mortimer B. Davis) 10 000 $
The Alfred B. Grossman Award of the EJLB Foundation
Dr. Michel Bouvier (Université de Montréal ) $5,000
Le prix Alfred B. Grossman de la Fondation EJLB
Dr Michel Bouvier (Université de Montréal ) 5 000 $
The Buckingham Lions Club Award in memory of Robert
Champagne
Dr. Jacques Genest Jr (Royal Victoria Hospital - MUHC) $5,000
Le prix Club Lions de Buckingham en mémoire de
Robert Champagne
Dr Jacques Genest Jr (Hôpital Royal Victoria - CUSM) 5 000 $
The Birks Family Foundation Award
Dr. Benoît Drolet (Hôpital Laval) $5,000
Le prix de la Fondation de la famille Birks
Dr Benoît Drolet (Hôpital Laval) 5 000 $
The Pfizer Canada Award
Dr. Louise Brissette (Université du Québec à Montréal) $5,000
Le prix Pfizer Canada
Dre Louise Brissette (Université du Québec à Montréal) 5 000 $
The Pratt & Whitney Canada Award
Dr. M’hamed Bentourkia (Université de Sherbrooke) $5,000
Dr. Nicolas Noiseux (CHUM - Hôtel-Dieu) $5,000
Le prix Pratt & Whitney Canada
Dr M’hamed Bentourkia (Université de Sherbrooke) 5 000 $
Dr Nicolas Noiseux (CHUM - Hôtel-Dieu) 5 000 $
133
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
The award of Excellence in Memory of Claire Laforest and Rosario
Boucher
Dr. Jolanta Gutkowska (CHUM - Hôtel-Dieu) $5,000
Le prix d’excellence à la mémoire de Mme Claire Laforest et M.
Rosario Boucher
Dre Jolanta Gutkowska (CHUM - Hôtel-Dieu) 5 000 $
The sanofi-aventis Award
Dr. Julie L. Lavoie (CHUM - Hôtel-Dieu) $5,000
Le prix Sanofi-aventis
Dre Julie L. Lavoie (CHUM - Hôtel-Dieu) 5 000 $
Training bursaries for PhD students in Cardiovascular and Stroke
research
Partnership between the Fonds de la recherche en santé du
Québec (FRSQ), the Réseau en santé cardiovasculaire (RSCV) and
the Heart and Stroke Foundation of Québec (HSFQ).
Bourses de formation à des étudiants de 3e cycle en recherche
cardiovasculaire et vasculaire cérébrale.
Partenariat entre le Fonds de la recherche en santé du Québec
(FRSQ), le Réseau en santé cardiovasculaire (RSCV) et la
Fondation des maladies du cœur du Québec (FMCQ).
The partners offer Training bursaries for PhD students working
with researchers receiving a Grant-in-Aid from the Heart and
Stroke Foundation of Québec (HSFQ).
Les partenaires offrent des bourses d’aide à la formation pour le
soutien d’étudiants au doctorat, travaillant avec des chercheurs
ayant obtenu une subvention de la Fondation des maladies du
cœur du Québec.
In 2006-2007, 2 bursaries were given:
Pedro Geraldes (Dr. Jean-François Tanguay, Montreal Heart
Institute) $20,000
Carl Bolduc (Dr. Jonny St-Amand, Université Laval) $20,000
En 2006-2007, deux bourses ont été offertes :
Pedro Geraldes (Dr. Jean-François Tanguay, Institut de
Cardiologie de Montréal) 20 000 $
Carl Bolduc (Dr. Jonny St-Amand, Université Laval) 20 000 $
Nova Scotia
Nouvelle-Écosse
Gregory Ferrier Award
An award of excellence in research given to the highest rated
HSFNS GIA recipient in honour of Dr. Greg Ferrier.
2006-2007 Recipient:
Dr. Ratika Parkash (Dalhousie University) $5,000
Prix Gregory Ferrier
Prix d’excellence remis au lauréat de subvention de la FMCNÉ
ayant obtenu la plus haute note, en hommage au Dr Greg Ferrier.
Lauréat 2006-2007 :
Dre Ratika Parkash (Université Dalhousie) 5 000 $
Prince Edward Island | Île-du-Prince-Édouard
Project Grant | Subvention de projet
Principal Investigator and Co-Investigator(s)
Institute of Principal Investigator
Project
Keywords
Term
Chercheur principal et co-chercheur(s)
Institut du chercheur principal
Projet
Mots-clés
Durée
Sweeney-Nixon, Marva
University of Prince Edward Island
Blueberry assay project.
*Amount may change depending on circumstances
*Le montant peut changer selon les cirsconstances
134
2004-2009
06-07 $
Total $•
$10,000
$50,000
APPENDIX
Annexe
F
RESEARCH COMMITTEE MEMBERS
MEMBRES DU COMITÉ DE LA RECHERCHE
Dr. Grant Pierce (St. Boniface Hospital Research Centre) was the 2006-2007 Chair of the Heart and Stroke Foundation of Canada Scientific Review Committee.
Dr Grant Pierce (Centre de recherche de l’Hôpital Saint-Boniface) était président du Comité d’examen scientifique de la Fondation des maladies du cœur
en 2006-2007.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
2006-2007 Research Policy and
Planning Advisory Committee
Comité consultatif sur les
politiques et la planification de
la recherche 2006-2007
Carolyn Brooks, Chair
Robert Côté, MD, Vice-Chair
Montreal General Hospital
Roy Cameron, PhD
University of Waterloo
Karen Chad, PhD
University of Saskatchewan
David Fedida, MD, PhD,
University of British Columbia
Danielle Groleau, PhD
Jewish General Hospital
John Hinds
Canadian Community Newspapers Association
Carol Jillings, PhD
Ex-Officio
Chair, Heart and Stroke Foundation of Canada Board of Directors
Marilyn Mackay-Lyons, PhD
Dalhousie University
Grant Pierce, PhD
Chair, Scientific Review Committee
St Boniface Hospital Research Centre
Margaret L. Rand, PhD
Hospital for Sick Children
David Shragge, MD
Misericordia Community Hospital
Lisa Southern
Labour Relations Board of British Columbia
Carolyn Brooks, présidente
Robert Côté, M.D., vice-président
Hôpital général de Montréal
Roy Cameron, Ph.D.
Université de Waterloo
Karen Chad, Ph.D.
Université de la Saskatchewan
David Fedida, M.D., Ph.D.,
Université de la Colombie-Britannique
Danielle Groleau, Ph.D.
Hôpital général juif
John Hinds
Canadian Community Newspapers Association
Carol Jillings, Ph.D.
Présidente ex officio, conseil d’administration de la Fondation
des maladies du cœur du Canada
Marilyn Mackay-Lyons, Ph.D.
Université Dalhousie
Grant Pierce, Ph.D.
Président, Comité d’examen scientifique
Centre de recherches de l’Hôpital Saint-Boniface
Margaret L. Rand, Ph.D.
Hospital for Sick Children
David Shragge, M.D.
Hôpital communautaire Misericordia
Lisa Southern
Commission des relations de travail de la Colombie-Britannique
136
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
2006-2007 Scientific Review
Committee Leadership
Direction des Comités d’examen
scientifique 2006-2007
Grant Pierce, PhD, Chair
St. Boniface Hospital Research Centre
Heather Arthur, PhD, Vice Chair
McMaster University
Clinical cardiovascular and cerebrovascular research: mechanistic
studies and clinical trials/health services research
John Parker, MD, Chair
Mount Sinai Hospital
William Ghali, MD, Deputy Chair
University of Calgary
Integrative studies: genetic manipulations/imaging/
bioengineering
Sheldon Magder, MD, Chair
Royal Victoria Hospital
Mansoor Husain, MD, Deputy Chair
Toronto General Hospital
Basic science stroke/neurophysiology/neuroregulation
James Peeling, PhD, Chair
University of Manitoba
Phyllis Paterson, PhD, Deputy Chair
University of Saskatchewan
Grant Pierce, Ph.D., président
Centre de recherches de l’Hôpital Saint-Boniface
Heather Arthur, Ph.D., vice-président
Université McMaster
Recherche clinique cardiovasculaire et vasculaire cérébrale;
études mécanistes et essais cliniques / recherche sur les services
de santé
John Parker, M.D., président
Hôpital Mont Sinai
William Ghali, M.D., vice-président
Université de Calgary
Études intégratives; manipulations génétiques / imagerie /
bio-ingénierie
Sheldon Magder, M.D., président
Hôpital Royal Victoria
Mansoor Husain, M.D., vice-président
Hôpital général de Toronto
Recherche fondamentale sur les AVC / neurophysiologie /
neurorégulation
James Peeling, Ph.D., président
Université du Manitoba
Cellular biochemistry, pharmacology and electrophysiology A
Geoffrey Pickering, MD, PhD, Chair
London Health Sciences Centre
Phyllis Paterson, Ph.D., vice-président
Université de Saskatchewan
Elissavet Kardami, PhD, Deputy Chair
University of Manitoba
Biochimie cellulaire, pharmacologie et électrophysiologie A
Geoffrey Pickering, M.D., Ph.D., président
Centre des sciences de la santé de London
Cellular biochemistry, pharmacology and electrophysiology B
David Fedida, MD, PhD, Chair
University of British Columbia
Elissavet Kardami, Ph.D., vice-présidente
Université du Manitoba
Rhian Touyz, MD, PhD, Deputy Chair
University of Ottawa
Biochimie cellulaire, pharmacologie et électrophysiologie B
David Fedida, M.D., président
Université de la Colombie-Britannique
Molecular basis of cardiac and vascular function
Timothy Lee, PhD, Chair
Dalhousie University
Rhian Touyz, M.D., Ph.D., vice-président
Université d’Ottawa
137
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
Kelly McNagny, PhD, Deputy Chair
University of British Columbia
Fondements moléculaires de la fonction cardiaque et vasculaire
Timothy Lee, Ph.D., président
Université Dalhousie
Thrombosis/lipid and lipoproteins/fundamental nutrition research
Mark Hatton, PhD, Chair
McMaster University
Richard Lehner, PhD, Deputy Chair
University of Alberta
Behavioural research/health psychology/rehabilitation/
population health
Blaine Ditto, PhD, Chair
McGill University
Robert D. Reid, PhD, Deputy Chair
University of Ottawa Heart Institute
Senior Personnel (New Investigator/Career Investigator/
Visiting Scientist)
Grant Pierce, PhD, Chair
St. Boniface Hospital Research Centre
Heather Arthur, PhD, Deputy Chair
McMaster University
Doctoral Research Awards
Laszlo Bajzar, PhD, Chair
University of Alberta
Research Fellowships
Andrew Krahn, MD, Chair
London Health Sciences Centre
Kelly McNagny, Ph.D., vice-président
Université de la Colombie-Britannique
Thrombose / lipides et lipoprotéines / recherche fondamentale
sur la nutrition
Mark Hatton, Ph.D., président
Université McMaster
Richard Lehner, Ph.D., vice-président
Université de l’Alberta
Recherche comportementale / psychologie de la santé /
réadaptation / santé des populations
Blaine Ditto, Ph.D., président
Université McGill
Robert D. Reid, Ph.D., vice-président
Institut de cardiologie de l’Université d’Ottawa
Personnel de direction (Jeune chercheur / chercheur de carrière /
chercheur invité)
Grant Pierce, Ph.D., président
Centre de recherches de l’Hôpital Saint-Boniface
Heather Arthur, Ph.D., vice-présidente
Université McMaster
Bourses de recherche doctorale
Laszlo Bajzar, Ph.D., président
Université de l’Alberta
Bourses de recherche
Andrew Krahn, M.D., président
Centre des sciences de la santé de London
138
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
2006-2007 Provincial Research
Advisory Committee Chairs
2006-2007 Présidents des
comités consultatifs de
recherche provinciaux
Heart and Stroke Foundation of British Columbia and Yukon
Research Advisory Committee
Glen F. Tibbits, PhD, Chair
Simon Fraser University
Heart and Stroke Foundation of Alberta, Northwest Territories
and Nunavut Research and Medical Advisory Committee
Henry J Duff, MD, Chair
University of Calgary
Heart and Stroke Foundation of Saskatchewan Ad Hoc Research
Advisory Committee
Douglas C. Hodson, QC, Chair
MacPherson Leslie & Tyerman LLP
Heart and Stroke Foundation of Manitoba Research Advisory
Committee
Patrick C. Choy, PhD, Chair
University of Manitoba
Heart and Stroke Foundation of Ontario Grant Allocation
Sub-Committee
Philip W. Connelly, PhD, Chair
St. Michael’s Hospital
Heart and Stroke Foundation of Ontario Research Committee
Ross D. Feldman, MD, Chair
Robarts Research Institute
Comité scientifique de la Fondation des maladies du coeur du
Québec
Pédro D’Orléans-Juste, PhD, Président
Université de Sherbrooke
Heart and Stroke Foundation of New Brunswick Medical Advisory
Committee
Carolyn Baer, MD, Chair
South East Regional Health Authority
Heart and Stroke Foundation of Nova Scotia Scientific Advisory
Committee
Roger S. McLeod, PhD, Chair
Dalhousie University
Comité consultatif de la recherche de la Fondation des maladies
du cœur de Colombie-Britannique et du Yukon
Glen F. Tibbits, Ph.D., président
Université Simon Fraser
Comité consultatif scientifique et médical de la Fondation des
maladies du cœur de l’Alberta, des Territoires du Nord-Ouest et
du Nunavut
Henry J Duff, M.D., président
Université de Calgary
Comité consultatif ad hoc sur la recherche de la Fondation des
maladies du cœur de la Saskatchewan
Douglas C. Hodson, QC, président
MacPherson Leslie & Tyerman LLP
Comité consultatif de la recherche de la Fondation des maladies
du cœur du Manitoba
Patrick C. Choy, Ph.D., président
Université du Manitoba
Sous-comité d’attribution des subventions de la Fondation des
maladies du cœur de l’Ontario
Philip W. Connelly, Ph.D., président
Hôpital St. Michael’s
Comité de recherche de la Fondation des maladies du cœur de
l’Ontario
Ross D. Feldman, M.D., président
Institut de recherche Robarts
Comité scientifique de la Fondation des maladies du cœur du
Québec
Pedro D’Orléans-Juste, Ph.D., président
Université de Sherbrooke
Comité consultatif médical de la Fondation des maladies du
cœur du Nouveau-Brunswick
Carolyn Baer, M.D., présidente
Direction régionale de la santé du Sud-Ouest
Comité consultatif scientifique de la Fondation des maladies du
cœur de la Nouvelle-Écosse
Roger S. McLeod, Ph.D., président
Université Dalhousie
139
APPENDIX
Annexe
G
DEFINITION OF HEALTH RESEARCH THEMES
DÉFINITION DES THÈMES DE LA RECHERCHE EN SANTÉ
Dr. Patti-Jean Naylor (University of Victoria) and Dr. Heather McKay (University of British Columbia) were recipients in 2006-2007 of an award funded
through the Federation Research Fund’s Childhood Obesity Operating Grants 2005 initiative, titled Evaluating the effectiveness of the dissemination of
Action Schools! BC: a socio-ecological intervention to increase physical activity and healthy eating in school children.
Dre Patti-Jean Naylor (Université de Victoria) et Dre Heather McKay (Université de la Colombie-Britannique) étaient lauréates 2006-2007 d’une bourse
financée dans le cadre de l’initiative Subventions de fonctionnement en obésité infantile 2005 du Fonds de recherche de la Fédération, pour leur projet
intitulé Evaluating the effectiveness of the dissemination of Action Schools! BC: a socio-ecological intervention to increase physical activity and healthy
eating in school children.
Heart and Stroke Foundation | Research Report 2006-2007
Fondation des maladies du cœur | Rapport de recherche 2006-2007
The four themes of health research as defined by the Michael
Smith Foundation for Health Research are:
Les quatre thèmes de la recherche en soins de santé, tels que
définis par la Fondation Michael Smith pour la recherche en soins
de santé, sont :
I. Basic Biomedical
Research with the goal of understanding normal and abnormal
human function, at the molecular, cellular, organ system, and
whole body levels, including the development of tools and
techniques to be applied for this purpose; developing new
therapies or devices which improve health or the quality of life
of individuals, up to the point where they are tested on human
subjects. Studies on human subjects that do not have a
diagnostic or therapeutic orientation.
II. Clinical
Research with the goal of improving the diagnosis and treatment
(including rehabilitation and palliation) of disease and injury;
improving the health and quality of life of individuals as they pass
through normal life stages. Research on, or for the treatment of,
patients.
III. Health Services/Systems
Research with the goal of improving the efficiency and
effectiveness of health professionals and the health care system,
through changes to practice and policy. Health services research
is a multidisciplinary field of scientific investigation that studies
how social factors, financing systems, organizational structures
and processes, health technologies, and personal behaviours
affect access to health care, the quality and cost of health care,
and ultimately our health and well-being.
IV. Population Health
Research with the goal of improving the health of the Canadian
population, or of defined sub-populations, through a better
understanding of the ways in which social, cultural, environmental,
occupational, and economic factors determine status.
142
I. La recherche biomédicale fondamentale
Recherche qui a pour but de comprendre le fonctionnement
normal et anormal de l’organisme humain aux niveaux
moléculaire, cellulaire, organique ou de l’ensemble du corps,
incluant la création d’outils et de techniques à cet effet, ainsi
que le développement de nouveaux traitements ou dispositifs
qui améliorent la santé et la qualité de vie, jusqu’à leur
application sur des sujets humains. Ces études portant sur des
sujets humains sont sans but diagnostique ou thérapeutique.
II. La recherche clinique
Recherche qui a pour but d’améliorer le diagnostic et le
traitement – incluant la réadaptation et les soins palliatifs –
de maladies ou de blessures, ainsi que la santé et la qualité de
vie des personnes qui traversent des étapes normales de la vie.
Recherche sur le traitement lui-même ou les moyens de traiter
les patients.
III. Les systèmes et services de santé
Recherche qui a pour but d’améliorer l’efficacité des
professionnels et des systèmes de santé en agissant sur la
politique et la pratique professionnelle. La recherche menée
par les services de santé est un domaine multidisciplinaire
d’investigation scientifique qui étudie l’impact des facteurs
sociaux, des systèmes de financement, des structures et des
procédés organisationnels, des technologies de la santé et des
comportements personnels sur l’accès aux soins de santé, sur
leur qualité et leurs coûts, et enfin, sur notre santé et notre
bien-être à tous.
IV. La santé de la population
Recherche qui a pour but d’améliorer la santé de la population
canadienne, ou de sous-groupes de population spécifiques,
grâce à une meilleure compréhension de la façon dont les
facteurs sociaux, culturels, environnementaux, occupationnels
et économiques définissent le statut des personnes.
Millions of Canadians will develop some form of heart disease or stroke
over their lifetime - and some at a much too early age. As a leading funder
of heart and stroke research in Canada, the Heart and Stroke Foundation
continues to find the answers that lead to earlier diagnoses, better treatments
and new insights into how to prevent and manage these diseases. To protect
your health and the health of those you love, the Foundation also provides
the most up-to-date healthy living information to Canadians, based on the
most current, evidence-based research.
Des millions de Canadiens et de Canadiennes souffriront d’une forme ou
d’une autre de maladie du cœur ou d’accident vasculaire cérébral (AVC) au
cours de leur vie, et certains à un âge beaucoup trop précoce. Étant l’un des
principaux bailleurs de fonds de la recherche cardiovasculaire et vasculaire
cérébrale au pays, la Fondation des maladies du cœur continue de chercher
des réponses menant à des diagnostics plus précoces, à de meilleurs
traitements et à de nouvelles avenues de prévention et de contrôle de ces
maladies. Afin de protéger votre santé et celle de vos personnes chères, la
Fondation offre aux Canadiens et aux Canadiennes l’information la plus
récente sur les modes de vie, à partir des dernières découvertes scientifiques.
To find more information about heart disease, stroke, how
to live a healthy life, as well as how you can offer much
needed support in your community, visit
­www.heartandstroke.ca
or call
1-888-HSF-INFO (1-888-473-4636)
Pour de plus amples renseignements sur les modes de vie
sains, les maladies du cœur et les AVC offerts par la
Fondation des maladies du cœur, et pour apprendre
comment vous pouvez offrir un soutien essentiel dans
votre collectivité, visitez le site
­www.fmcoeur.ca
ou faites le
1-888-473-INFO (1-888-473-4636)