Natural tetrapeptide and analogues agent for stimulating hair growth

Natural tetrapeptide and analogues
agent for stimulating hair growth and
slowing down loss of hair
CONTEXT
Our reference :
86887-01
Status des brevets
French patent
application FR0501672
filed on February 18th,
2005, entitled «
Utilisation cosmétique
d’au moins un
tetrapeptide naturel AcN-SER-ASP-LYS-PRO
ou un de ses analogues
en tant qu’agent pour
ralentir la chute des
cheveux et/ou stimuler
leur croissance »
Inventors
In humans, hair growth and renewal are determined mainly by the activity of hair follicle
and the surrounding dermo-epidermal environment. There are many causes of hair loss,
an extremely emotional distressing disease that can make those afflicted particularly
vulnerable. In most cases, this disease is of hereditary or hormonal origin. Depending on
the type of hair loss, the existing treatments are not efficient on a small scale of time. They
offer a temporary solution and often need to use invasive techniques. Therefore it would
be useful to provide the cosmetic or pharmaceutical industry with an effective product.
TECHNICAL DESCRIPTION
The present invention concerns a natural tetrapeptide Acetyl-N-Ser-Asp-Lys-Pro
(AcSDKP) and its analogues that stimulate vital hair functions by activating epithelial stem
cells of the hair follicles and by restructuring the follicles epithelial sheaths. Consequently,
AcSDKP stimulates hair growth by activating the cell proliferation and the production of
collagen IV, keratin 19 and laminin 5 along the length of the hair.
DEVELOPMENT STAGE
In ex vivo model of scalp explants maintained in survival AcSDKP induces morphological
and molecular modifications matching the criteria of hair growth;
In vitro AcSDKP :
- significantly stimulates the growth of Human Hair Follicle Dermal Papilla Cells (HFDPC),
- induces bifunctional activation of a longevity-related protein, SIRT1 (synthesis and
enzymatic activity). An important increase in the synthesis of SIRT1 by the keratinocytes
mediated by AcSDKP may also contribute to hair cell rejuvenation.
BENEFITS
Joanna BAKALA
Jean Yves
LALLEMAND
Jerôme BIGNON
In addition to easy and relatively low cost synthesis of analogues, these compounds
present very low toxicity for the body and therefore are devoided of side effects on
patients.
The economic interest for such a treatment is important since around two thirds of men
suffer with hair loss by the age of 35, and 40% of sufferers are women.
INDUSTRIAL APPLICATIONS
Status Commercial
Research agreement,
exclusive or non
exclusive licenses
This most advanced application of this natural tetrapeptide and its pharmaceutical byproducts is the cosmetic use for stimulating hair growth and increasing hair density. Taken
separately or combined with another active ingredient, the cosmetic compositions can be
included in any pharmaceutical form conventionally used for topical application.
This invention can also allow a cosmetic process for the treatment and/or prevention of
hair loss, particularly alopecia.
For further information, please contact us (Ref 86887-01)
Laboratoires
Institut de Chimie des
Substances Naturelles
ICSN, UPR 2301 CNRS
in Gif-sur-Yvette,
France.
Keywords :
Natural tetrapeptide
Hair follicle Hair loss
Stem cells Collagen IV
Laminin 5 Keratin 19,
Alopecia
Powered by TCPDF (www.tcpdf.org)